Preliminary Program

April 5, Monday

08.00-09.00 Registration and Connecting participants, Technical Information Hall Conference-Hall 09.00-11.30 Openning Ceremony (Greetings from Officials, Welcome from ISS and Baykonur, concert) Hall Conference-Hall 11.30-12.30 Plenary session 11.30-11.50 Preparation for the first human space flight (for the 60th anniversary of the flight of Yu.A. Gagarin) P. Vlasov, M. Kharlamov 11.50-12.10 Space medicine from Gagarin to nowadays O.I. Orlov 12.10-12.30 Documentary film about the training to first human flight 12.30-14.00 Welcome Reception Hall Conference-Hall 14.00-15.20 Plenary session Russian manned program. State and prospects 14.00-14.20 V.A. Soloviev The European Space Agency’s Human Research activities: past, present and future 14.20-14.40 A. Van Ombergen Decades of fruitful Russian German cooperation in Space Life Sciences 14.40-15.00 C. Rogon, K. Stang, M. Girgenrath, M. Braun, P. Graef Half century of scientific and technical collaborations between France and Russia for bilateral Manned Space Flights 15.00-15.20 L. Suchet 15.20-15.40 Break Hall Conference-Hall 15.40-16.00 Plenary session The NASA Human Research Program: Overcoming the Challenges of Exploration Spaceflight 15.40-16.00 S. Platts, J. McPhee IAF celebrating the 60th Anniversary of Human Spaceflight Era 16.00-16.20 Ch. Feichtinger The Peaceful Use of Space 16.20-16.40 W. Tianyi 16.40-17.00 Discussion Hall Conference-Hall Moon and Mars Exploration (L. Zeleniy, O. Kotov, A. Grishin, S. Ryazanskiy, E. Fomina) 17.00-17.50 Round Table Moderator A.Stepanova 18.00-18.30 Transfer to boat 18.00-20.00 Lunch April 6, Tuesday

08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky 09.00-10.00 Plenary session The Investigation Of Combined Impact Of Ionizing Radiation And Hypogravity On Central Nervous System As A Key Problem Of Deep Space Missions Safety 09.00-09.20 A.S. Shtemberg Radiobiology of the visual system 09.20-09.40 M. Ostrovsky Neuroradiobiology Issues and Radiation Risk in Deep Space Flights 09.40-10.00 E.A. Krasavin Hall Mussorgsky Interplanetary missions. Vision of cosmonauts and astronauts (S.K. Krikalev, O.V. Kotov, GCTС, etc.) 10.00-10.40 Round Table Moderator: A. Stepanova 10.40-11.00 Coffee Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Proteomics, Transcriptomics and Influence of hypomagnetic Neuroscience problems in Deep Space New approaches and concepts for Genomics in Space – 11.00-13.00 11.00-13.00 11.00-13.00 conditions in long-term space 11.00-13.00 Missions SANS/VIIP risk prevention Personalized Medicine flights OMICS S. Robin Elgart/ A. Shtemberg R- C. Stern/ O.Man`ko O. Orlov / Ch.H. Borchers / L. Buravkova Chairs: Chairs: Chairs: Chairs: r A. Kussmaul R-r A. Smoleevskiy R-r O. Popova/M. Onuchina R-r D. Kashirina

Spaceflight-Associated Changes in Space flights associated changes the Perivascular Spaces of in astronauts plasma eexosomes Astronauts derived rna: biomarker G. Barisano, F. Sepehrband, E. Experiment to study the impact of identification Space Radiation and Central Nervous Tomilovskaya, I. Rukavishnikov, I. hypomagnetic fields on the D.A. Goukassian, M. Truongcao, System Impacts: NASA Standards and Nosikova, L. Litvinova, A. 11.00-11.15 11.00-11.15 11.00-11.15 organism of a person «ARFA-19» 11.00-11.15 P. Dubey, C. Gonzalez, A. Bajpai, Evidence Rumshiskaya, V. Petrovichev, V. V.Yu. Kukanov, M.R. Onuchina, Z. Cheng, M.K. Khlgatian, A. S.R. Elgart Sinitsyn, E. Pechenkova, S. Laureys, J. A.L.Vasin, O.I. Orlov Arakelyan, P. Mills, K. Walsh, S. Sijbers, B. Jeurissen, S. Sunaert, P. Addya, A. Evans, M. Coleman, A. Parizel, S. Jillings, H. R. Collins, M. Brojakowska , K. Fish, R. Kishore, Law, A. Grishin, D. Roberts, V.N.S. Garikipati Floris L. Wuyts Changes in the profile of proteins associated with the Effects of cranial proton Optic Nerve Head Stady In Space Arfa-19 experiment: simulation of functions of the cardiovascular irradiation on visuomotor Flight the magnetic field under exposure system in space and ground- 11.15-11.30 behaviour in nonhuman primates 11.15-11.30 I.A. Makarov, I.V. Alferova, V.V. 11.15-11.30 11.15-11.30 L.V. Tereshchenko, I.D. Shamsiev, conditions based model experiments Bogomolov, Yu.I. Voronkov, V.V. I.V. Bondar, E.A. Krasavin, A.V. M.R. Onuchina, A.L. Vasin V.B. Rusanov, L.Kh. Krivolapov, E.G. Khorosheva Latanov Pastushkova, A.M. Nosovsky, I.M. Larina

Transcriptomic signatures and The influence of 8-hour’s upstream regulation in human Long-term cns effects of low-dose compensation of the Earth's skeletal muscle induced by galactic cosmic radiation on wildtype The functional state of the optic magnetic field on the autonomic inactivity and aerobic exercise: a 11.30-11.45 and alzheimer’s-like mice 11.30-11.45 nerve after a long-term space flight 11.30-11.45 11.30-11.45 regulation of the heart meta-analysis M.K. Schroeder, B.R. Price, K.A. Khan, S.N. Danilichev, O.M. Manko E.Yu. Bersenev, A.L. Vasin, V.Yu. D. V. Popov, P. A. Makhnovskii, R. B.J. Caldarone, C.A. Lemere Kukanov, O.I. Orlov O. Bokov, F.A. Kolpakov, O. L. Vinogradova

Changes in the blood proteome Individual characteristics of central Eye examinations in bed rest studies of cosmonauts with external Influence of reduced magnetic nervous system as an important factor to maintain ocular health and to signs of microvascular injury at field on human central of radioresistance define successful application of the first day after landing 11.45-12.00 11.45-12.00 11.45-12.00 hemodynamics 11.45-12.00 A.A. Perevezentsev, A.G. Belyaeva , K.B. countermeasures C. Stern, D. I.N. Goncharov, L.Kh. O.V. Popova, Е.S. Luchitskaya, V.Y. Lebedeva-Georgievskaya, A.S. Mittelstaedt, S. Stupp, K. Klink, M. Pastushkova, M.I. Koloteva, A.G. Kukanov, V.B. Rusanov Shtemberg Pittius, S. Ritter, A. Händel Goncharova, T.M. Glebova, D.N. Kashirina, K.S. Kireev, I.M. Larina

Neuroplasticity and Microgravity: Gene Expression Profile Changes in the Medial The Impact of Deep Space Radiation on Functional condition of the visual Parasympathetic regulation of Vestibular Nuclei and the Cognitive Performance: From Biological system under the condition of one- hemodynamics in healthy men Inferior Olive Nuclei of the Brain 12.00-12.15 Sex to Biomarkers to Countermeasures 12.00-12.15 year wintering at the antacrtic 12.00-12.15 12.00-12.10 under hypomagnetic conditions of Mice after a 30-Day Space S. Rosi, K.Krukowski, K. Grue, K. station VOSTOK N.Yu. Osetsky, O.M. A.V. Demin, A.V. Suvorov Flight on the Bion-M Satellite Rieneker, A.R Ferguson, G. Nelson Manko , E.A. Ilyin, O.I. Orlov P. Fortygina, P. Kolosov, A. Beletskyi, M. Roshchin, P. Khaitovich, P. Balaban Dynamics Of The Functional Activity The effect of physical activity on Of The Retina After Four Months Of blood plasma proteome in 21 Isolation In A Sealed Object Gas Exchange and Ventilation in day head-down bed rest The Novel Extraplanetary Radiation Simulated A Space Flight Healthy Humans during 8-h D.N. Kashirina, A.G. Brzhozovskiy, 12.15-12.30 Countermeasures Initiative (NERCI) 12.15-12.30 12.15-12.30 12.10-12.20 M.V. Zueva, V.V. Neroev, I.V. Hypomagnetic Exposure L.Kh. Pastushkova, A.G. B.J. Sishc, J. Saha, J. Zawaski, R. Elgart Tsapenko, Yu.A. Bubeev, O.M. J.A. Popova, A.V. Suvorov Goncharova, A.S. Kononikhin, Manko, A.E. Smoleevskiy, A.M. E.N. Nikolaev, Ch.H. Borchers, Aleskerov I.M. Larina

Molecularbiomarkersof susceptibility forlate-onset neuropathologies and multivariate modeling of individual Assessment Of Visual Functions The susceptibility of volunteer’s risks for operation-relevant behavioral During A 4-Month Isolation In The Human pain threshold in T cells to immunomodulation deficits after exposure to space 12.30-12.45 12.30-12.45 SIRIUS-19 Project Manko O.M., 12.30-12.45 hypomagnetic environment A.V. 12.20-12.30 during long-term dry immersion radiation Gracheva M.A., Rozhkova G.I., Polyakov, A.R. Niyazov, S.O. Fedyay A. Gornostaeva, A. Ratushnyy, L. A.J. Wyrobek, B.M. Rabin, R.A. Britten, Smoleevskiy A.E., Vasilyeva N.N. Buravkova A.M. Mora,R.B. Gunier,H.E.Witkowska,M. Albertolle, T. Straume

Stress caused by psychological Brain stem cells, new neurons, and and physiological stress 12.45-13.00 radiation significantly changes the G. Enikolopov concentration of circulating DNA 12.30-12.45 in human blood plasma Morphometric Status Of The Human Dynamics of human P.E. Umriukhin, E.S. Ershova, S.A. Retina As A Biomarker Of Adaptive neurophysiological characteristics Ponomarev, N.N. Veiko, S.V. Plasticity And Dysfunctions Of The under the influence of a Kostyuk 12.45-13.00 Central Nervous System In Chronic 12.45-13.00 Irradiation effects on the cognitive trait hypomagnetic environment Stress expression and neurogenesis in D.V. Schastlivtseva, Yu.A. Bubeev, The method for direct mass D.A.Podyanov, O.M. Manko, M.V. 13.00-13.10 laboratory mice of different genotypes T.I. Kotrovskaya spectrometric analysis of I.I. Poletaeva, N.A. Ogienko, O.V. Zueva, A.M. Aleskerov biological samples using porous Perepelkina, A.V. Revishchin 12.45-13.00 samplers I.A. Popov, S.I. Pekov, M.A. Shamraeva, D.S. Bormotov, R.E. Levin, I.M. Larina, E.N. Nikolaev 13.00-14.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Radiation during deep space Astrobiology, Space Biology and Multidisciplinary Studies related 14.00-15.30 Neuroscience 14.00-15.30 14.00-15.30 exploration: risk estimation and 14.00-15.30 Space Biotechnology with Humans in Space countermeasure Ch.Kourtidou Papadeli/ S. Schneider/ P. Rettberg/ V. Sychev D. Goukassian/ V. Shurshakov H.-C. Gunga/ A. Maillet Chairs: Yu. Bubeev R-r A. Chairs: Chairs: Chairs: R-r D. Komissarova R-r A. Savinkina R-r A. Kussmaul Smoleevskiy

ISS – the prediction platform for Exposure of microorganisms in exploration missions EVA Reduced Glial Scarring Through outer space performance 14.00-14.10 Hypergravity Exposure 14.00-14.10 E.A. Deshevaia, S.V. Fialkina, A.A. 14.00-14.10 М.M. Kharlamov, B.I. Kryuchkov, Ya. Lichterfeld Guridov, V.A. Shcherbakova, E.V. V.M. Usov, T.B. Kukoba, Y.A. Shubralova, O.S. Tsygankov, V.K. Ilyin Bubeev, E.V. Fomina Radiation Risk in Lunar Missions: Cerebral activation to imagination of Estimation and Countermeasures spatial navigation is altered after 6 14.00-14.15 V.A. Shurshakov, A.V. Shafirkin, months in microgravity O.A. Ivanova, K.O. Inozemtsev, A.E. J. Annen, E. Tomilovskaya, S. Larroque, Resistance mechanisms of Bacillus Lishnevskii, R.V. Tolochek Influence of a female gender on S. Jillings, E. Pechenkova, A. subtilis-20 and Bacillus licheniformis- the efficiency of work in a crew 14.10-14.20 Rumshiskaya, L. Litvinova, I. Nosikova, I. 14.10-14.20 24 strains 14.10-14.20 of manned spacecraft Rukavishnikov, A. Van Ombergen, S. P.J. Osipova, S.V. Poddubko, D.S. A.Yu. Kikina Sunaert, P.M. Parizel, V. Sinitsyn, V. Karpov Petrovichev, P. zu Eulenburg, B. Jeurissen, J. Sijbers, A. Demertzi, S. Laureys, F.L. Wuyts

Sustainable and Reversible effects of spaceflight on human brain function and connectivity Astrobiological aspect of the The results of biomedical S. Jillings, E. Pechenkova , E. resistance of fungal communities research on board of the ISS and Radiation Dose Assessment Tomilovskaya , A. Rumshiskaya, L. from desert soils to the impact of on Earth - a contribution to the Throughout The Solar System 14.20-14.30 Litvinova, I. Nosikova, I. Rukavishnikov, 14.20-14.30 the simulated Martian conditions 14.15-14.30 14.20-14.30 medical support of orbital and M.I. Dobynde, V.A. Shurshakov , J. A. Van Ombergen , S. Sunaert, P.M. M.O. KrIuchkova, E.A. Vorobyova, autonomous flights Guo, S.I. Svertilov, O. Ploc Parizel, V. Sinitsyn, V. Petrovichev, P. zu A.E. Ivanova, V.S. Cheptsov, A.K. A.R. Kussmaul, M.S. Belakovskiy, Eulenburg, B. Jeurissen, J. Sijbers, J. Pavlov A.B. Sakharova Annen, S. Laureys, A. Demertzi , F.L. Wuyts Pharmacological induction of hypobiosis: trends and prospects. Effects of short-term isolation and Part I. Reversible torpor and Ground laboratory studies of Feasibility Study of Habitat chronic sleep deprivation on cognitive hypothermia radiation effect of space rays in Design Commonalities for Mars 14.30-14.40 performance 14.30-14.40 N.M. Zakharova, Y.S. Tarahovsky, I.S. 14.30-14.45 14.30-14.45 interplanetary space Transit and Surface Missions K. Brauns.,A. Friedl-Werner.,H.C. Fadeeva, N.P. Komelina, M.O. V.M. Skorkin O. Bannova, S. Haeuplik- Gunga., A.C. Stahn Khrenov, O.V. Glushkova, D.A. Meusburger Prokhorov, V.P. Kutyshenko, A.L. Kovtun An approach to define Brain Changes in Response to a Pharmacological induction of Evaluation of Ionizing Radiation requirements and evaluation Combined Exercise and Sensory hypobiosis: trends and prospects. Effects and Mitigation Techniques philospohy for crew comfort in Stimulation Countermeasure During Part II. Long-term pharmacological for Inflatable Space Habitats in short duration human Long-Duration Antarctic Missions torpor with feedback-controlled 14.40-14.50 14.40-14.50 14.45-15.00 Deep Space Missions 14.45-15.00 spaceflight mission A.C. Stahn, D.F. Dinges , D. Roalf, R.C. drug administration S. Anantaram, A. Varma, P.M. P.A. Ravishankar, A. Kibe, S. Gur, A. Friedl-Werner, K. Brauns, S. Y.S. Tarahovsky, N.P. Komelina, I.S. Ravishankar, K.G. Vinod, P. Vishnu, K. G. Vinod, P. Mendt, H.C. Gunga, S. Kühn , A. Fadeeva , A.L. Kovtun, N.M. Sankaravelayutham Sankaravelayutham Chouker, M. Basner Zakharova

Human-systems integration Neurophysiological mechanisms of The motility of spermatozoa of mice needs analysis for on-board cognitive processes when performing and Drosophila melanogaster anomaly resolution during earth 14.50-15.00 operator tasks of different complexity 14.50-15.00 changes differently under modelling 15.00-15.10 independent operations D.V. Schastlivtseva, T.I. Kotrovskaya, B. microgravity conditions T. Panontin, M. Parisi, K. Johannes, Yu.A. Bubeev I.V. Ogneva McTigue, Shu-chieh Wu, A. Vera Radi-N2 and Matroshka-R: Cell respiration of spermatozoa of Measurements of Neutron the fruit fly Drosophila Radiationon the International melanogaster under simulated Space Station (2009 – 2020) 15.00-15.15 15.00-15.05 microgravity M.B. Smith, H.R. Andrews, H. Ing, A.А. Sukonkina, M.A. Usik, N.S. E.M. Johnston, S. Khulapko, M.R. The effects of sleep disturbances on Biryukov, Yu.S. Zhdankina, I.V. Koslowsky,R. Machrafi,I. Nikolaev, GAUSS Precursor Mission for working memory are mediated by Ogneva V. Shurshakov, L. Tomi Mars Exploration 15.00-15.10 changes in melatonin level 15.10-15.25 R. Di Roberto, S. Carletta, N. Yu.V. kraintseva, K.M. Liaukovich, M.O. Transient increase in the rate of cell Sparvieri, F. Graziani Shilov respiration of mouse spermatozoa under exposure to simulated 15.05-15.10 hypergravity M.A. Usik, Yu.S. Zhdankina, N.S. Biryukov, A.A. Sukonkina, I.V. Ogneva

Fighting microbial biofilms in space by ESA's upcoming space Psychological and microbiology and material science «Plasma – biological object» psychophysiological chronic experiment BIOFILMS interaction: study of basic 15.10-15.20 stress predictors 15.10-15.20 K. Siems , D. Müller , L. Maertens, R. 15.25-15.35 mechanisms A.A. Avdeichik, O.M. Manko, Y.A. Van Houdt , R. L. Mancinelli , N. A.K. Martusevich, A.G. Galka, E.S. Bubeev, E.V. Kostenko Caplin , J. Krause , R. Demets , A. Golygina Tortora , M. Laue , F. Mücklich , C. E. Lifetime risk of tumor Hellweg, R. Möller development in c57b1/6j mice exposed to a single full body

exposed to a single full body Microgravity induced resting-state 15.15-15.30 gamma and simGCRsim radiation networks’ and metabolic alterations A. Brojakowska, M. Bisserier, M.K. during sleep onset The microbiome of the International Khlgatian, S. Zhang , V. Gillespie, Y. Ch.A. Frantzidis, I. Machairas, S. Gylou, Space Station (ISS) Dai, L. Hadri, D.A. Goukassian Crystalloscopic test-system for Ch.M. Nday, S.N. Ketseridou, M. P. Rettberg, M. Mora, L. Wink, I. cold plasma effects detection 15.20-15.30 Mitsiou, Ch. Giantsios, Ch.S. Plomariti, 15.20-15.30 Kögler, A. Mahnert, P. Schwendner, 15.35-15.40 A.K. Martusevich, A.G. Galka, E.S. M. Velana, A. Xatzicharistou, A. Karkala, R. Demets, C. Cockell, T. Alekhova, A. Golygina, A.N. Tuzhilkin, A.S. D. Kontaxopoulou, E. Stanitsa, S. Klingl, R. Krause, A. Zolotariof, A. Fedotova Fragkiadaki, S.G. Papageorgiou, P. Alexandrova, Ch. Moissl-Eichinger Bamidis, Ch. Kourtidou-Papadeli, J. Vernikos 15.30-15.40 The effect of previous spaceflight on Green Moon Project: Encapsulated otolith-mediated ocular counter-roll in and Pressurised Habitat for Plants cosmonauts after long duration on the Moon (Habitability and Space spaceflight 15.30-15.40 Agriculture) C. Schoenmaekers, L. Kornilova, D. 15.30-16.30 Discussion 15.40-16.30 Discussion J.M. Ortega-Hernandez, J. Pla-Garcia, Glukhikh, G. Clément, H. MacDougall, I. J. Martinez-Frias, E. Sanchez- Naumov, Ch. De Laet, L. Wille, S. Jillings, Rodriguez, J. Hernandez-Narvaez F. Wuyts 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coffee Break, Short Talks Hall Mussorgsky 17.00-18.00 Plenary session NASA Artemis Missions & Human Research Opportunities 17.00-17.20 L. Abadie NASA Update on Spaceflight Associated Neuro-ocular Syndrome: Recent Findings and Future Plans 17.20-17.40 M. Stenger Review of Space Radiation Health Risks for Exploration Missions 17.40-18.00 F.A. Cucinotta 18.00-18.30 Discussion April 7, Wednesday

08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky 09.00-10.00 Plenary session Psychological and Interpersonal Issues in Space: On-Orbit, Mars, and Beyond 09.00-09.20 N. Kanas Biomedical Research In Antarctica and Human Flights Into Deep Space 09.20-09.40 E.A. Ilyin Our skeleton adapts to the conditions of space flight but the return to the Earth is challenging 09.40-10.00 L. Vico, V. Novikov, G. Vassilieva Hall Mussorgsky Women in Space 10.00-10.40 R. Table Moderator: A. Stepanova 10.40-11.00 Coffee Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Studies of sensory-motor Changes in Cardiovascular and SIRIUS project. Psychological aspects of system functions in Dry 11.00-13.00 11.00-13.00 11.00-13.00 Pulmonary Systems as a Risk of 11.00-13.00 Medical Support in the Autonomous Flight isolation and confinement Immersion and Bedrest Interplanetary Missions experiments B. Vessey/V. Gushin/C. Tafforin Dr. Jenkin/E. Tomilovskaya R-r J. Jordan/U. Hoffmann O. Kotov/V. Bogomolov Chairs: Chairs: Chairs: Chairs: R-r A. Savinkina A. Saveko R-r A. Salnikov R-r Yu. Smirnov Head down bed rest effects the Approaches to the assessment of Human Capabilities Assessments for Features of communication of isolated perception of upright: cardiovascular functionality at the Autonomous Missions: A Multi-Team crew of mixed national and gender perceptual support for bed rest ISS Research Effort to Reduce Risk in the Human- 11.00-11.10 composition with the control center 11.00-11.10 11.00-11.15 11.00-11.15 as a microgravity analog E. Luchitskaya, I. Funtova, V. System Integration Architecture for Future D.M. Shved, V.I. Gushin, A.K. Yusupova, M. Jenkin, L. R. Harris, R. Rusanov Deep-Space Missions A.O. Savinkina, S.A. Lebedeva Herpers S.K. Robinson, B.F. Gore, A.M. Whitmire Arterial Stiffness assessed by Sleep architecture changes estimated Pulse Wave Velocity is Self-training of the crew members of the The role of a doctor in a long-distance space during 21-day dry immersion not affected during 6 months SIRIUS 18/19 project using the 6df flight Yu.V. Ukraintseva, G.V. Kovrov, Spaceflight 11.10-11.20 software 11.10-11.20 11.15-11.20 11.15-11.30 O.V. Kotov, M.S. Belakovskiy, A.R. Kussmaul S.I. Posokhov, E.Yu. Bersenev, E. Luchitskaya, J-N. Hönemann, I. I. D.V. Schastlivtseva, B. Johannes, T.I. K.A. Pikalov, D.V. Kondukova, Funtova, S. Möstl, H. Reuter, J. Tank, Kotrovskaya, Yu.A. Bubeev E.S. Tomilovskaya F. Hoffmann

Head-down tilt position, but Emotional state dynamics and its not the duration of bed rest Features of heart rate variability Spaceflight duration and the mortality of assessment with subjective and objective affects resting state and myocardium energy cosmonauts 11.20-11.30 methods in SIRIUS-19 experiment 11.20-11.30 11.20-11.30 11.30-11.45 electrocortical activity metabolism in space flight Y. K.V. Betts, I.V. Bukhtiyarov, G.I. Tikhonova, I.B. A.O. Savinkina, P.G. Kuznetsova, D.M. K. Brauns, A. Friedl-Werner, D. Yakhya, V. B. Rusanov Ushakov, Yu.I. Voronkov Shved, V I. Guschin H.C. Gunga, A.C. Stahn Interpersonal Interactions, Strict head down tilt (HDT) bed Prolonged exposure to chronic Communications And Group rest: the improvement of a intermittent hypoxia: effects on Effectiveness Of The SIRIUS-19 Crew ground-based microgravity cardiac autonomic modulation Biofeedback system for enhanced motor From Integrated Psychological And analogue for sans-related 11.30-11.40 11.30-11.40 11.30-11.40 during sleep 11.45-12.00 control under microgravity Ethological Data research M.A. Maggioni, H.-C. Gunga, N. J.C. Johnson, P.A. Johnson, A. Mardon A.G. Vinokhodova, C.Tafforin, P.G. A. Noppe, M. von der Wiesche, Hellner, S. Mendt, Lang Tapia M Kuznetsova, A. Savinkina, K. Eskov, V.I. N. Klischies, A. Nitsche, E. Gushin Mulder

Phases of adaptation to the Structural and functional effects of Emotional relationships as a way to conditions of «dry» immersion full-body space radiation exposure overcome the isolation stress during according to the on the right ventricle and lungs Mental Health in Prolonged Space Travel 11.40-11.50 spaceflight simulation 11.40-11.50 neurofunctional state of 11.40-11.50 M. Bisserier, M.K. Khlgatian, C. 12.00-12.15 J.C. Johnson, P.A. Johnson, A. Mardon A.G. Vinokhodova, I. Solcova, V.I. Gushin, volunteers Grano, S. Zhang, A. Brojakowska, K. P.G. Kuznetsova M.A. Skedina, A.A. Kovaleva, Fish, D.A. Goukassian, L. Hadri M.G. Potapov

Impact Of Long-Term Dry Monitoring physical activity, Cardiovascular Disease Risk Immersion On Signaling psychological, physiological parameters Modeling for Astronauts: Making Pathways In Human Soleus On the possibility of using GVS-technology for and independent of environmental the Leap from Earth to Space Muscle visual flight control in extreme situations 11.50-11.55 factors in the experiment SIRIUS-19 11.50-12.00 11.50-12.00 Z.S. Patel, I. Plante, S.R. Blattnig, 12.15-12.30 N.A. Vilchinskaya, O.V. E. Soto, V.V. Alexandrov, K.V. Tikhonova, E.S. E.Yu. Bersenev, V.V. Tsetlin, G.P. R.B. Norman, M.P. Little, L.C. Turtikova, S.A. Rozhkov, K.A. Tomilovskaya Stepanova, N.V. Degterenkova, S.O. Simonsen, J.L. Huff Sharlo, S.A. Tyganov, B.S. Fedyay Shenkman Accuracy Of Power Results and prospects of studies of Impact of isolation on crew performance Maintenance By Muscles Of changes in lower limbs veins in during the SIRIUS-19 campaign The Shoulder Girdle After 21- exposure to real and simulated 11.55-12.05 12.00-12.10 12.10-12.20 S. Lizy-Destrez, E. Gil Calle, D. Mimoso, V. Day Dry Immersion microgravity Martin Estrana, R.N. Roy, V. Peysakhovich E. A. Orlova, O. L. Vinogradova, A.V. Salnikov, G.A. Fomina Pressure compression bandages for the A. S. Borovik treatment of postural hypotension following 12.30-12.45 re-entry Predictions of heart rate and Development and integration of a space- P.A. Johnson, J.C. Johnson, A. Mardon Sensorimotor Tasks During 21- oxygen uptake during exercise for flight simulator for the SIRIUS Analogue 12.05-12.15 12.10-12.15 Day Dry Immersionrpinskaya 12.20-12.30 activities in Space Mission: SIMKSILL-RU and SIMSKILL-VR I.I. Shoshina, E.S. Tomilovskaya U. Hoffmann, U. Drescher, F. Faber, M.B. Bruguera, S.L. Bermúdez, R. Ewald J. Koschate

Effect of 5-day Dry Immersion Electromagnetic compatibility of on the human foot morphology cardiovascular and respiratory Social research in space and military assessed by computer biomedical equipment in ground missions is the "HOUSE WITH THREE plantography and soft tissues based studies of human space 12.15-12.20 FLOORS"… 12.15-12.25 12.30-12.40 stiffness measuring exploration K. Sykorova Bernardova, P. Tefelnerova, E. A.A. Saveko, L.E. Amirova, I.Yu. A.I. Dyachenko, A.V. Orlov, A.V. Chroustova, R. Bahbouh Ermakov, Yu.I. Smirnov, E.S. Suvorov Tomilovskaya

The First Female Dry Immersion (NAIAD- 2020): Design and Specifics of a 3-Day Experimental estimation of the effectiveness Study Quantitative Approach Towards an of prospective methods of protection of the E.S. Tomilovskaya, A.A. Saveko, Analysis of Structure and Dynamics of hearing organ under conditions of harmful L.E. Amirova, I.N. Nosikova, I.V. 12.45-13.00 12.20-12.25 Social Relationships in Space Crews 12.25-12.35 exposure to noise Rukavishnikov, R.V. P. Tefelnerova, K. Bernardova, E. Reduced vagal modulations of L.Yu. Marchenko, E.E. Sigaleva, O.B. Pasekova, Chernogorov, S.A. Lebedeva, Chroustova, R. Bahbouh heart rate during overwintering in E.I. Matsnev I.Yu Ermakov, I.I. Ponomarev, Antarctica I.S. Zelenskaya, T.A. Shigueva, 12.40-12.50 M.A. Maggioni, G. Merati, P. N.V. Shishkin, V.V. Kitov, G.Yu. Castiglioni, S. Mendt, H.-C. Gunga, Vassilieva, O.I. Orlov A.C. Stahn

Three days of dry immersion reduce mitochondrial Summary of Human Factors Behavioral respiration rate in m. soleus in Performance Exploration Measures in women 12.25-12.40 SIRIUS ‘19 12.35-12.45 E.S. Motanova, R.O. Bokov, T.F. S.T. Bell, P. Roma, J. Miller, S. Whiting, L. Vepkhvadze, E.M. Lednev, E.S Landon .Tomilovskaya, O.I. Orlov, D.V. Popov Study Of The Effects Of Low- Frequency Electrical Examining Teamwork of Space Myostimulation During 5-Day Crewmembers and Mission Control Dry Immersion On The 12.40-12.55 Personnel under Crew Autonomy: A 12.45-12.50 Hyperreflexia And Vertical The Advantage of Supine and Multiteam System Perspective Balance Standing Heart Rate Variability U. Fischer, K. Mosier N.V. Shishkin, L.E. Amirova, I.N. Analysis to Assess Training Status Biomedical support of manned space missions Nosikova, E.S. Tomilovskaya and Performance in a Walking beyond the low Earth orbit as an 12.50-13.00 Ultramarathon 13.00-13.15 organizational control system Effects Of High Frequency M.A. Maggioni, L.C. Rundfeldt, H.-C. Yu.I. Smirnov, E.Yu. Mamonova Electromyostimulation On Gunga, M. Joerres, G. Merati, M. Characteristics Of The Accuracy Steinach Of Control Of Movements 12.55 Discussion 12.50-12.55 Under Dry Immersion Conditions T.A. Shigueva, V.V. Kitov, Yu.A. Koryak, E.S. Tomilovskaya 13.00-14.00 Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov 14.00-15.30 14.00-15.30 Effects of gound-based models 14.00-15.30 Skeletal Unloading and Other 14.00-15.30 Space Psychology and Human Factors in V.Abeln/V.Ilyin M. Maggioni/E. Tomilovskaya L. Vico/ G. Vassilieva R-r N. Kanas/ V. Gushin R-r Chairs: Chairs: Chairs: Chairs: R-r - Yu. Popova R-r - E. Luchitskaya Т. Agaptseva A. Savinkina Cardiovascular and autonomic effects of nutritional Features of dynamics of the professional supplementation during Subjective perception of time in space flights operators and volunteers microflora in longterm and analogs: study methods 14.00-14.10 isolation experiments of various duration 14.00-14.10 bed rest 14.00-14.10 A.K. Yusupova, V.I. Gushin, D.M. Shved, N.S. V.K. Ilyin, D.V. Komissarova, N.A. Usanova, M.A. Maggioni, G. Merati, P. Analysis of osteodensitometry data Supolkina, A.I. Chekalina Yu.A. Morozova Castiglioni, S. Mendt, A. Friedl- of cosmonauts after the first and Werner, K. Brauns, H.-C. Gunga, repeated flights considering the A. C. Stahn 14.00-14.15 timing of the examination after landing K.V. Gordienko, V.E. Novikov, G. Yu. Changes in crew cohesion and habitat use Hemodynamic Reactions Vassilieva during two 1-year antarctic winter-over Features Of A Female Body In mission 14.10-14.20 Conditions Of "Dry" Immersion 14.10-14.20 M. Basner, D. F. Dinges, A. Stahn, J. Nasrini, E. M.R. Vasina, E.S. Luchitskaya, Hermosillo, A.J. Ecker, M. Smith, B. Johannes, Human periodontal tissues state during E.S. Tomilovskaya, V.B. Rusanov B. Healey, F.P. van den Berg, H.C. Gunga, N. long-term isolation in confined habitat Pattyn, T.M. Moore, D. Roalf, R.C. Gur 14.10-14.15 V.K. Ilyin, M.P. Rykova, E.N. Antropova, Z.O. Solovieva, M.A. Skedina, A.A. Dynamics of human ventilation Kovaleva, A.M. Nosovsky response during 21-day "dry" Cognitive styles & multimodal communication immersion 14.20-14.30 14.20-14.35 codes for deep space K.S. Parshin, Yu.A. Shulagin, R. Toscano, A. Toscano R.N. Zaripov, E.S. Ermolaev, A.I. Dyachenko, A.V. Suvorov

Effects of Thigh-cuffs on bone Manifestation of hemorrhagic remodelling unbalance induced by syndrome after head-up tilt short-term dry immersion and the tests in 21-day dry immersion 14.15-14.30 associated metabolic markers Neuropsychological effects of isolation in the form of plasma M.T. Linossier, L. Peurière, M. Visual Dwell Time on instruments is and physical exercise regimen during proteome modification Normand, M.P. Bareille, A. Beck, C. associated with Manual Docking Performance SIRIUS-19 D.N. Kashirina, L.Kh. Bonneau, G. Gauquelin-Koch, L. Vico 14.15-14.25 14.30-14.40 14.35-14.45 S. Piechowski, W. Pustowalow, M. Arz, J. V. Abeln, T. Klein, F. Möller, U. Hoffmann, Pastushkova, A.G. Goncharova, Rittweger, C. Mühl, E. Mulder, O. T. Wolf, J. J. Popova, E.A. Fomina, G. Vassilieva, S. I.N. Goncharov, I.V. Jordan Schneider Rukavishnikov, A.G. Brzhozovskiy, A.S. Kononikhin, M.I. Koloteva, E.S. Tomilovskaya, I.M. Larina Effect of 3-day "dry" immersion The Effects of 120 Days Confinement on the veins condition in the During the SIRIUS Project on lower extremities of healthy Physiological Kinetics and Inhibitory women of reproductive age Control 14.40-14.50 (NAYADA-2020) F. Möller. , J. Koschate. , M. Haeger. , I.M. Vasilev, O.I. Efremova , S.G. U.Hoffmann, E.A. Fomina, N. Didkovskaya, Modeling of bone organs under the Gavrilov , E.S. Tomilovskaya, Sexual wellbeing & sexual security in isolation U. Drescher, F. Steinberg influence of external force factors G.Yu. Vassilieva & confinement environments 14.30-14.45 T.V. Baltina, V.V. Yaikova, A.O. 14.45-14.55 14.25-14.35 D. Grevers, T. Amelung, M.A. Maggioni, N. Fedianin, M.E. Baltin, N.V. Kharin, Novel antimicrobial fleece inhibits Pattyn, H. - C. Gunga Evaluation and assessment of O.V. Gerasimov, O.A. Sachenkov growth of human-derived biofilm- hemodynamic regulation – forming Staphylococci during the SIRIUS- Influences of the leg position 19 isolation 14.50-15.00 during tilt testson left E. Grohmann, D. Wischer, D. Schneider, ventricular stroke volume A. Poehlein, O. Wagner, S. Kharin, N. J. Koschate, F. Möller, Z. Acar, E. Novikova, R. Haag, R. Daniel Jacobi, U. Hoffmann 14.35-14.45 Gender characteristics of the metabolic reactions of volunteers an experiment Analysis of bacterial profiles of with 120-day isolation in a pressurized AGBRESA participants – a study volume the background of stressful concerning terrestrial influences astronauts under simulated A.A. Markin, O.A. Zhuravleva, D.S. microgravity Kuzichkin, L.V. Vostrikova, I.V. 15.00-15.10 E. Muratov, A. Himmelmann, A. Zabolotskaya, Y.V. Zhuravleva Thermoneutral temperature Schröder, S. Koch, K. Siems, E. mitigates hind-limb unloading- Mulder, C. Hellweg, P. Frings- induced bone loss by preserving MSG – Movement Space and Group health in Meuthen, C. Moissl-Eichinger, energetic metabolism a restricted area U. Rolle-Kampczyk, K. Förstner, 14.45-15.00 14.55-15.05 L. Peurière, C. Mastrandrea, M.-T. D. Michaeli, T. Carmel, M. Rozložnik, K. R. Moeller Linossier, M. Paul, A. Vanden- Brünnemann 14.45-14.55 Bossche, M.-H. Lafage-Proust, L. Sleep and autonomic nervous system Gravity-dependent changes in Vico during a 4-months isolation experiment the functional state of the N. Laharnar, M. Glos, A.V. Suvorov, A.V. neuromotor apparatus of the Demin, T. Penzel, I. Fietze rat calf muscles 15.10-15.20 A.A Eremeev, A.O. Fedianin, T.N. Zaytseva, A.N. Babikova, T.V. Baltina 14.55-15.05 Study of autonomic regulation of circulation in conditions of prolonged Whole-body vibration: an 18 month isolation Gravity and mastoid effusion countermeasure evaluation of 15.05-15.15 A. Chernikova, O. Isaeva, O. Uss L. Lecheler, F. Paulke, L. Habitats in Extreme Environment and postmenopausal women

postmenopausal women Sleep loss and high task demand lead to 15.20-15.25 Sonnow, U. Limper, D. 15.00-15.15 15.05-15.20 Habitability – A Review P. Fernandez , H. Locrelle, C. fast and sloppy decision-making: eye- Schwarz, S. Jansen. J. Tank, J. S. Haeuplik-Meusburger, S. Bishop Bonneau, M. Normand, M.-H. tracking evidence from a visual search Jordan, J.P. Klussmann Lafage Proust, T. Thomas, L. Vico task 15.15-15.25 C. Mühl, S. Benderoth, D. Aeschbach Rat bone tissue in conditions of Study of the state of the auditory Lower body negative pressure: limited motor activity Assessment of the female operators‘ analyzer of the testers in the dynamics of current updates and T.V. Baltina, N.N. Kuntush, psychophysiological state under simulated a 4-month experiment with isolation 15.25-15.30 perspectives 15.15-15.30 15.20-15.30 A.O.Fedyanin, M.E. Baltin, N.V. microgravity using acoustic speech analysis "SIRIUS-19" N. Goswami, A. Blaber, S. Du Kharin, O.V. Gerasimov, O.A. S. Lebedeva, D. Shved, A. Savinkina I.V. Kutina Plessis 15.25-15.30 Sachenkov 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coffee Break, Short Talks Hall Mussorgsky 17.00-18.00 Plenary session Developing Autonomous Medical Capabilities for Exploration Spaceflight 17.00-17.20 K. Lehnhardt, B. Easter NASA Human Research Program – Overview of Behavioral Health and Performance Research in the SIRIUS Analog 17.20-17.40 A. Whitmire, B. Gore, B. Vessey, T. Williams The human research program suite of integrated one-year mission experiments (CIPHER): description and integration 17.40-18.00 M. Shelhamer, Ch. Oubre Discussion 18.00-18.30 April 8, Thursday

08.00-09.00 Registration and Connecting participants, Technical Information Hall Mussorgsky 09.00-10.00 Plenary session Planetary protection in interplanetary missions: problems, challenges and solutions 09.00-09.20 V.K. Ilyin Brain Changes in Response to Isolation and Confinement: The Need for Target-Specific Countermeasures 09.20-09.40 A. Stahn The effect of previous spaceflight on otolith-mediated ocular counter-roll in cosmonauts after long duration spaceflight ???? 09.40-10.00 F.L. Wuyts Hall Mussorgsky Young scientists 10.00-10.40 Round Table Moderator: A. Stepanova 10.40-11.00 Coffee Break, Short Talks Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Exercise and Countermeasures in Skeletal Muscle Under Conditions Of Real Habitability, Nutrition and Life 11.00-13.00 the Interplanetary Missions, 11.00-13.00 And Simulated Microgravity 11.00-13.00 11.00-12.20 Commercial Spaceflight Support in Space Exploration Countermeasure Evaluation Part 1 S. Schneider/ E. Fomina J. Rittweger/ B. Shenkman K. Beblo-Vranesevic /V. Ilyin V.S. Zander/ I. Saenko R- Chairs: Chairs: Chairs: Chairs: R-r - S. Smoleevskiy R-r S. Tyganov R-r K. Shef r A. Savinkina Microbial Monitoring in the EDEN ISS Greenhouse, a Mobile Space technologies in the Test Facility in Antarctica neurorehabilitation 11.00-11.10 K.Beblo-Vranesevic, J. Fahrion, P. 11.00-11.15 O.Ya. Kochuneva, V.G. Mitkovsky, I.V. Сoordination among the lower limb Zabel, D. Schubert, M. Mysara, R. Saenko muscles during locomotion on the Van Houdt, B. Eikmanns, P. Inactivity and unloading as determinants passive-mode treadmill in Mars500 Rettberg 11.00-11.15 11.00-11.30 of muscle impairment in microgravity and in the long-term space flight C. Reggiani Linking biomedical research and A. Meigal, D. Ivanov, A. Smoleevskii, Operation of the Russian technological innovation for Human U. Monakhova, E. Fomina "Electron-VM" Oxygen health in Space and on earth – Overview 11.10-11.20 Generation System aboard the 11.15-11.30 of current projects and future plans in the: International Space Station envihab V.Yu. Proshkin M. von der Wiesche, A. Noppe, A. Nitsche, J. Jordan

PRBS kinetics test as tool to The optimality criteria for crop E-Nose technique application in the determine effectiveness of physical Mitigating muscle and bone loss during lighting inside plant growth unit diagnosis of pneumonia training spaceflight: GSK3 as a potential cellular for extended manned space T. Woehrle, S. Matzel, F. Pfeiffer, L. Kamm, 11.15-11.30 11.30-11.50 11.20-11.30 11.30-11.40 U. Hoffmann, J. Koschate, N.Yu. target missions D. Moser, M. Feuerecker, J. Grosser, J. Lysova, L. Thieschäfer, U. Drescher, V. Fajardo A.A. Buryak, Yu.A. Berkovich, Lenic, S. Zander Vanja, O. Schoele-Schulz, E.A. Fomina O.A. Ochkov M. Dolch, V. Fetter, A. Choukér The water management on prospective space stations Aerospace medicine in the fight against L.S. Bobe, A.A. Kochetkov, A.S. 11.30-11.40 11.40-11.50 coronavirus infection Tsygankov, S. Yu. Romanov, A.G. I.P. Levchuk, A.A. Medenkov Zeleznyakov, P.O. Andreychuk, Y.E. Sinyak

Modeling of EEG signals via Partial Directed Coherence and Deep Learning for the identification of suitable artificial gravity levels in a Short Arm Human Changes in motor control depending 11.50-12.00 Centrifuge as part of rehabilitation of on the level of physical performance 11.30-11:40 patients with neurological disorders in space flight S.N. Ketseridou , I. Machairas , C. Giantsios N.Yu. Lysova, E.A. Fomina , C. Frantzidis, C. Plomariti , P. Kourtidou- The rationale of the key trace Papadeli contaminants list for chemicals, polluting the air of manned Biosensory medical technology for non- 11.40-11.50 Plantar afferent stimulation effects in spacecraft invasive diagnostics of oxidative stress postural muscle. Lessons from human A.A. Pakhomova, L.N. based on the biomarkers in exhaled 11.50-12.20 Mukhamedieva, D.S. Ozerov breath and rat studies 12.00-12.10 B.S. Shenkman, S.A. Tyganov D.S. Ozerov, L.N. Moukhamedieva, J. Grosser, J. Lenic, A. Choukér, M. Dolch, Yu. Smirnov, D. Tsarkov, O. Schoele-Schulz, V. Fetter Continuous and intermittent Device for mechanical urine collection in artificial gravity as a 12.10-12.20 women in microgravity and clinical use 11:40-11.55 countermeasure to the cognitive S.A. Lebedeva, N. Komarov, M. Stern effects of 60 days of head-down tilt bed rest Promising research areas for the 12.20-13.00 Space Tourism operational control over the Characteristic features of human human health toxic risks in long- adaptation to long-term space term manned space flights flights on the International Space D.S. Ozerov, L.N. Mukhamedieva Station 11.50-12.05 A. Kuritsyn, A. Kumar 11.55-12.05 Chairs: I.A. Nichiporuk, S.A. Chistokhodova, R-r - N. Chub E.A. Fomina, T.B. Kukoba, N.Yu. Lysova, T.V. Zhuravleva, A.N. Agureev

Possibilities for treating sensorimotor disturbances in astronauts and cosmonauts after Directions of commercialization of long-duration space flights manned space exploration 12.05-12.20 M.F. Reschke, E.S. Tomilovskaya, The role of muscle tone in the genes 12.20-12.30 A.A. Kuritsyn, B.I. Kryuchkov, A.A. M.J. Rosenberg, I.S. Kofman, I.V. expression regulation that control the Solving nutrition Problems in Kovinskiy Rukavishnikov, V.V. Kitov,N.Yu. destruction of contractile and 12.20-12.40 12.05-12.20 Interplanetary Space Flights Osetsky, G. Clement, N. Gadd, S. cytoskeletal proteins of unloaded rat A.N. Agureev, K.A.Shef Wood soleus T.L. Nemirovskaya Peripheral Cooling in the Human Governance of space tourism Short Arm Centrifuge Can Reduce 12.20-12.30 12.30-12.40 A. Jha , A. Kibe, A. Kumar Sinha, V.R Orthostatic Intolerance Lalithambika O. Opatz, H-C. Gunga, N. Kagelmann Bioreactor technology as key Acute effect of hyper gravity on the component of providing food neuromuscular control in drop products astronaut in far space jumps and drop landings 12.30-12:40 12.20-12.30 D.V. Maklakov, S.V. Nadezhdin J. Waldvogel, K. Freyler, K. Albracht, B. Stäudle, E. Monti, M. Helm, A. Approach for evolving medical criterions & Gollhofer, M. Narici, R. Ritzmann human tolerance limits for future space 12.40-12.50 Mathematical prediction of gas tourists Adenosine Biomarker Alterations release from polymers used A. Kumar, A. Jha, A. Kibe, A.Kumar Sinha during a 60 day Head Down Tilt Bed- onboard the manned spacecrafts Rest Study. Potential role of 12.40-12.50 Skeletal muscle atrophy in disuse and 12.30-12.40 P.V. Lashukov, D.S. Ozerov, N.A. reactive sledge countermeasure. microgravity: cellular and molecular Kotelnikov C. Nday, C. Frantzidis, P. Bamidis, C. 12.40-13.00 analyses on mice and human models Kourtidou-Papadeli R. Bottinelli Morphological characteristics of blood vessels and cytokine regulation of compensatory Intellectual property commercial issues reactions in the respiratory embracing the transfer of data between organs of rats under the orbital stations: the example of the lunar 12:50-13:00 Discussion 12.40-12.50 12.50-13.00 experimental fluid shift in the gateway orbital station and the cranial direction international space station M.Yu. Barantseva, L.N. J.Sandalinas Mukhamedieva, O.A. Dadasheva, D.S. Ozerov 13.00-14.00 Break, Short Talks Place Museum of Cosmonautics 15.00-17.00 60th Anniversary of the First Human Space Flight Chairs: R. Pischel, N. Artyukhina, M. Belakovskiy, R-r - A. Kussmaul Gagarin`s herritage in museum collections of Russia 15.00-15.30 V.L. Klimentov, M.S. Belakovskiy France-USSR / Russia Cooperation in the Medico-Biological Field: The Success Story in Human Space Flights and Automatic Flights 15.30-15.50 Christian Lardier , Lada Lekai and Galina Fomina The road to cosmonautics of Military Medic I.A.Kolosov 15.50-16.00 V.N. Kupriyanov Day of triumph of cosmonautics 16.00-16.15 A.A. Medenkov, M.V. Dvornikov 16.15-17.00 Tour Hall Mussorgsky Hall Tolstoy Hall Pushkin Hall Chekhov Immunology Education and Outreach in Space The Problems of Muscle Artificial Intelligence, VR, Telemedicine in 14.00-15.30 14.00-15.30 14.00-15.30 and Biochemistry for 14.00-15.30 Sciences Part 2 Interplanetary Missions and on the Earth Personalized Space Medicine Ch.Rogon/ L. Buravkova C. Reggiani/ B. Shenkman A. Chouker/ S. Ponomarev A. Stahn/A. Smoleevskiy Chairs: Chairs: Chairs: Chairs: R-r D. Kashirina R-r S. Tyganov R-r A. Pakhomova R-r D. Shved Fibrinolytic system status after Human spaceflight outreach – space flights Artificial intelligence technologies in the Deregulation of costamere components challenges and strategy for a D.S. Kuzichkin, A.A. Markin, O.A. system of accounting for the capabilities 14.00-14.15 14.00-14.20 in unloading muscle atrophy 14.00-14.10 14.00-14.10 developing nation Zhuravleva, Z.A. Krivitsina, T.V. and abilities of cosmonauts L. Gorza A. Kibe, A. Jha, A. Kumar Sinha Zhuravleva, L.V. Vostrikova, M.I. N.M. Kozlova, A.A. Medenkov Koloteva, I.V. Zabolotskaya The effect of 4-month isolation in a pressurized facility on the phenotypic characteristics of dendritic cells obtained from Increasing Medical Students’ Inter-individual and intra-individual The role of ai powered autonomous human peripheral blood Accessibility to Aerospace Medicine variation of spaceflight-induced muscle avionic systems in interplanetary 14.15-14.30 14.20-14.40 14.10-14.20 monocytes 14.10-14.20 with an Online Course atrophy: Results from the EDOS-2 study spaceflight O.V. Kutko, S.M. Shulgina, S.A. T. Girgla, R. Ferguson J. Rittweger B.Bibhorr Kalinin, E.N. Antropova, M.P. Rykova, K.D. Orlova, V.A. Shmarov, D.D. Vlasova, A.A. Sadova, S.A. Ponomarev Key Predictors to Successfully Cope with the Yukon Arctic Ultra: The Longest and the Coldest Ai based classification algorithms to Space Policy, Management Systems, Ultramarathon identify warning signs during continuous 14.30-14.45 Public Sector 14.20-14.30 C. Kienast, L. Mascarell-Maricic, R. 14.20-14.30 monitoring of physiological parameters SXT Ariel Coker, A. Schalt, M. Wypukol, P.Biswal, S.Mishra, A. Jha, A. Kibeand, A. N.Genov, D. Grevers, M. Joerres, Kumar Sinha R. Mole, O. Opatz, H-C. Gunga, M. Regulation of skeletal muscle titin Steinach 14.40-14.55 expression during unloading Automatic primary medical diagnostics of I.M. Vikhlyantsev Interrelation of success in cosmonauts on long interplanetary adaptation to conditions of space expeditions flights with initial biochemical O.V. Perevedentsev, R.V. Chernogorov, Aerospace Science Popularization and neurohormonal status of V.M. Levanov 14.45-15.00 Education 14.30-14.45 cosmonauts 14.30-14.40 X. Huifeng I. Nichiporuk, O. Zhuravleva,A. Markin, D. Kuzichkin, S. Chistokhodova, T. Zhuravleva, L. Vostrikova

First results of the human innate immunity research during the 21- day “dry” immersion with an Automation of onboard crew health The relevance of Anticipation to the artificial gravity used as a monitoring system using artificial Searches for Alien Life in countermeasure 15.00-15.10 14.45-14.55 14.40-14.50 intelligence algorithms Astrobiology S.A. Ponomarev, S.M. Shulgina, S. Kumar, B. Pal Singh, A. Kibe, A. Jha, A. G. Profitiliotis Sex-based differences in muscle response S.A. Kalinin, E.N. Antropova, M.P. Kumar Sinha, V.R. Lalithambika in rats exposed to micro- and partial- Rykova, K.D. Orlova, O.V. Kutko, 14.55-15.15 gravity analogs V.A. Shmarov, D.D. Vlasova, A.A. M. Mortreux Sadova

Psychological support based on virtual reality in simulation experiments, isolation and space flights 14.50-15.00 I. Rozanov , V.Gushin, O. Rumin, O. The E-Nose Breath Gas Karpova, D.M. Shved, P. Kuznecova, A.O. Education and training in space Experiment Savinkina, R. Abdyuhanov biology and medicine: the J. Grosser, J. Lenic, J. Schmitz, V. experience of Institute of Virtual reality based simulator training for 15.10-15.20 14.55-15.10 Zander, A. Choukér, L.N. Biomedical Problems of RAS potentially dangerous and life critical Moukhamedieva, D.S. Ozerov, M. 15.00-15.10 emergency rehearsals E.V. Sotnezova, M.A. Levinskikh, E.V. Sphingolipids take part in regulation of Dolch, O. Schoele-Schulz, V. P. Biswal , S. Mishra, A. Jha , A. Kibe, A. Ezdakova, I.V. Andrianova muscle plasticity during gravitational 15.15-15.30 Fetter Kumar Sinha unloading A vision on psychological support in future I.G. Bryndina, A.V. Sekunov, V.V. Skurygin interplanetary spaceflights 15.10-15.20 I. Rozanov, O. Rumin, O. Karpova, V. Gushin, D. Shved 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 15.30-16.30 Discussion 16.30-17.00 Coffee Break, Short Talks Hall Mussorgsky 17.00-18.00 Plenary session Development of the design of a countermeasure system for Moon and interplanetary missions in ground and space experiments 17.00-17.20 E.V. Fomina Standard Measures during Spaceflight 17.20-17.40 G. Clement Past, Present, Future of Exercise and Human Performance in Space 17.40-18.00 M. Downs Discussion 18.00-18.30 18.30-18.50 Closing Remarks April 9, Friday - Business Day

10.00-13.00 18th DLR/IBMP Life Sciences Working Group Meeting (Restricted access) Chairs: O.I. Orlov, M.Braun

13.30-14.30 Seminar on the problems of effects of social isolation (Open access) Chairs: V.Gushin

15.30-20.30 NASA/IBMP Joint Working Group Meeting (Restricted access) Chairs: O.I. Orlov, C.Kundrot

The technical part of the Business Day is supported by the Ministry of Science and Higher Education of the Russian Federation in the frame of the project “Pavlov Center for Integrative Physiology to Medicine, High-tech Healthcare and Stress Tolerance Technologies”. Short Talks

Section Name Report Muscles MS-01 Lvova I. D. Transient activation of slow myosin expression after 3 days of rat hindlimb unloading is caused by calcium ions accumulation MS-02 Zaripova K.A. Role of ATP-dependent signalling in rat soleus muscle under hindlimb unloading MS-03 Kalashnikov V.E. The effect of electrical stimulation of rat hindlimb during 1-day mechanical unloading on KCC2 phosphorylation in motoneurons and anabolic and catabolic markers in soleus muscle MS-04 I. I. Paramonova The role of histone deacetylase 4 in the regulation of slow myosin expression at the early stage of gravitational unloading in the rat soleus muscle MS-05 Komarova M.Y. Fibro-adipogenic progenitor cells functions are altered during gravitation unloading MS-06 S.V. Rozhkov Restricted activity and protein synthesis in postural and locomotor muscles MS-07 Belova S.P. Restricted activity and protein synthesis in postural and locomotor muscles MS-08 K. Sharlo Support afferentation coregulates slow myosin expression and mitochondrial biogenesis and prevents unloading-induced fatigue in rat soleus muscle MS-09 M.S. Laughlin, Y.A. Koryak, J. Rittweger Changes in knee and ankle torque generation during a six-month space flight mission MS-10 Chloë De Laet, Ludmila Kornilova, Dmitrii Glukhikh, Catho Schoenmaekers, Hamish MacDougall, Steven T. The impact of long-duration spaceflight on the horizontal Vestibulo- Moore, Ivan Naumov, Leander Wille, Steven Jillings, Ocular Reflex (hVOR) Floris Wuyts Countermeasure CT-01 Strength-to-weight index at readaptation to Earth conditions after Romanov P.V., Kukoba T.B., Babich D.R. Fomina E.V. repeated space flights CT-02 Koloteva M.I. and Glebova Т.М. Preliminary Results Of Studying The Human Body Physiological Activities In Simulated Microgravity With Regular Artificial Gravity Sessions On A Short-Arm Centrifuge

CT-03 Lobanov, Orlov Mathematical modeling of the reaction of physiological systems of the body to the conditions of artificial gravity during preventive measures of adverse effects of weightlessness

CT-04 Darya Grdlichko, Elena Fomina Development of software for evaluation of the effectiveness of countermeasures for negative effects of prolonged exposure to weightlessness CT-05 Amanda Winters Benefits Beyond: Mindful Missions in Autonomy Creating an adaptive experience through movement. CT-06 Klishin G.Yu., Filatov V.N., Bogomolov A.V., Shishov Computer system for statoergometric testing A.A. Neuroscience NS-01 Selen Güney, Hüseyin Akbulut, Hasan Birol Çotuk, Adil EEG complexity features based machine learning discriminates Deniz Duru between different mental workload states in terrestrial and lunar gravity analog NS-02 Laurence R. Harris The Perception of Self-Motion in Microgravity Medical Support MS-01 Application Of A Neural Network In A Mobile Device To Monitor The Zh. Alimbayeva, Ch. Alimbayev, N. Bayanbay, K. OzState Of An Astronaut's Heart During A Flight MS-02 Polyakov A. V., Fedyay S. O., Niyazov A. R. Human pain threshold in space flight MS-03 FM Shvetsky, VI Potievskaya, VS Shiryaev, MB Motives for using the "ideal anesthetic" xenon Potievsky. MS-04 Kulikov V. B. Stochastic And Singular Analysis Of Fractal Signals For Space Biomedicine Systems MS-05 Bubeev Yu.A., Ryumin O.O. Use Of Virtual Reality Technologies In The Process Of Medical And Psychological Support Of Interplanetary Expeditions Cardiovascular CV-01 F. Hoffmann, J. Hoenemann, J. Rabineau, D. Orthostatic tachycardia and functional cardiac response following Mehrkens, D.A. Gerlach, S. Moestl, B.W. Johannes, strict head-down-tilt bedrest E.G. Caiani, P.-F.Migeotte, J. Jordan, J. Tank

CV-02 Levon R. Dilenyan, Georgy S. Belkaniya, Andrew K. Gravity factor in determination of hemodynamics regulatory setting Martusevich in human Neuroscience-Psy NS-PS-01 K. Brauns, A. Friedl-Werner, H.C. Gunga.,A.C. Stahn Effects of two months of bed rest and antioxidant supplementation on attentional processing NS-PS-02 A.A. Naumova, A.V. Khramtsova, A.S. Berezovskaya, E.AShort-term hindlimb unloading impairs dopaminergic regulation in the striatum of mice NS-PS-03 Rabichev I.E. Influence of gravity on organization of eye movements and visual perception NS-PS-04 A.C. Stahn.,M. Riemer.,T. Wolbers.,D.F. Dinges.,A. Altered Gravity Conditions Impair Spatial Cognition Friedl-Werner., K.Brauns.,S. Besnard.,Pierre Denise.,S. Kühn., H.C. Gunga NS-PS-05 Kalinski L., El Sheikh S., Peter C., Lichterfeld Y., Weber Enhancing Synaptic Plasticity in vitro using Novel Ketamine H., Hemmersbach R., Jordan J. and Liemersdorf C. Derivatives Multi MU-01 A.K. Martusevich, A.G. Galka, E.S. Golygina, A.N. Crystalloscopic test-system for cold plasma effects detection Tuzhilkin, A.S. Fedotova MU-02 Amanda Winters Mitigating the effects of Space Adaptation through Vestibular Yoga Training Hypomagnetic HP-01 Pasekova O.B., Sigaleva E.E. The Functional State Of The Human Hearing System And The Brainstem Acoustic Structures In The Simulated Hypomagnetic Field

HP-02 Medvedeva A.V., Tokmacheva E.V., Nikitina E.A., Role Of Stress Impacts Of Weakened Geomagnetic Field On Vasilieva S.A., Stefanov V.E., Surma S.V., Shchegolev Drosophila Memory Formation B.F., Savvateeva-Popova E.V. SANS SANS-01 O.M. Manko, N.Yu. Oseckij, M.A. Gracheva, S.A. Dynamics Of Visual Acute And Contrast Sensitivity In Winter Koskin, S.Yu. Golubev Conditions At The “Vostok” Antarctic Station SANS-02 Clinical and morphological portrait of cataract in dynamics from the Sh. Khan UV index according to Pakistani statistics SANS-03 Spaceflight-induced macro- and microstructural changes in the brain S. Jillings, A.Van Ombergen, E. Tomilovskaya, A. Rumshiskaya, L. Litvinova , I. Nosikova, E. Pechenkova, I. Rukavishnikov, S. Sunaert, P.M. Parizel, V. Sinitsyn, V. Petrovichev, S. Laureys, P. zu Eulenburg, J. Sijbers, F.L. Wuyts, B. Jeurissen SIRIUS SS-01 Naima Laharnar, Martin Glos, Maria Zemann, Julia Assessing and comparing effects of sleep restriction and sleep Schlagintweit, Joanna Fatek, Alexander V. Suvorov, fragmentation on the autonomic nervous system – a pilot study Atem V. Demin, Thomas Penzel, Ingo Fietze (ANSISS) Life Support LS-01 Shustrov T.L. Simulation modeling as an important tool for the production of life- support systems LS-02 Zaretsky B.F. Proshkin V.Y. Planetary base automated control system LS-03 Shef K.A., Ilyin V.K., Usanova N.A., Barantseva M.Yu. Study of the effect of a radiation-chemical factor on the intestinal microbiome of rats LS-04 Dymova A.A., Shef K.A., Malina O.V., Zaitsev S.N., Microecology of the Functional Cargo Block (FGB) under conditions Poddubko S.V. of long-term operation LS-05 Biological Risks and Its Implications for Crewed Interplanetary Malaya Kumar Biswal M.,Noor Basanta Das., Ramesh NaMissions 60 Anniversary ANN-01 Dvornikov M.V., Medenkov A.A. Founders of biomedical training of manned space flights

ANN-02 Medenkov A.A. Biomedical training of the first manned space flight Radiation RAD-01 O.A. Ivanova, V.A. Shurshakov, S.G. Drobyshev, K.O. Space Radiation Factor during the Flight of Biological Satellites Inozemtsev, R.V. Tolochek RAD-02 Skorkin V.M, Lifanov M.N. Research Of Composite Material For Improving Personal Protection Means Under Gamma Radiation RAD-03 R. G. Hinshaw, J. Park, D. Y. Kim, R. E. Tanzi, C. A. New Human Neural Cell Models of Low-Dose Space-Like Radiation Lemere Exposure RAD-04 K. Fish, M. K. Khlgatian, C. Grano, M. Bisserier, S. Longitudinal evaluation of cardiac function and structure in apoe Zhang, A. Brojakowska, V. Chepurko, E. Chepurko, V. null and C57BL/6J mice after gamma and space-type radiation Gillespie, Y. Dai, L. Hadri, R. Kishore, and D.A. exposure Goukassian Bones BO-01 Lukicheva N. A., Gordienko K. V., Ratushnyy A. Yu., The content of hormones and markers of bone metabolism in the Vassilieva G. Yu. blood of rats after 7-day antiorthostatic suspension with the use of denosumab Space Psychology SP-01 Lebedeva S., Shved D. Preliminary results of a comparative study of the human psychophysiological state under simulated microgravity without countermeasures and with the use of centrifugation Astrobiology AB-01 Bulat S.A., Verbenko V.N., Yaroshevich T.L., Cheptsov Significant (in dozen times) attenuation of gamma-radiation induced V.S. dsDNA damage at -195.8 temperature exposure