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Home , Pantothenic acid, Picamilon

CAPABILITIES Capabilities

Table of Contents

Introduction ...... 3

Chromatography ...... 5

LC/MS/MS ...... 8

UPLC ...... 9

Gas Chromatography ...... 11

Inorganic Chemistry ...... 12

General Chemistry ...... 14

Microbiology ...... 19

Nutritional Supplement Panel ...... 21

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Lake City, UT 84104 USA [email protected] 2 Capabilities

We offer comprehensive testing solutions for the and Food & Beverage industries. As a full-service, ISO/ IEC 17025 accredited, third-party contract laboratory, we provide services to multinational brands through the entire supply chain including: raw material suppliers, contract manufacturers, brand manufacturers, retail brand owners and etc.

We utilize robust and accurate methods specifically designed for assay analysis of complex matrix samples by Ultra Performance Liquid Chromatography (UPLC), Gas Chromatography, and specialized Mass Spec (LC-MS/MS and GC-MS/MS). We also offer trace metal and testing services by Inductively Coupled Plasma Mass Spectroscopy (ICP-MS) and Direct Mercury Analyzer (DMA) as well as possess a vast Fourier Transform Infrared Spectroscopy (FTIR) identity testing library, and much more.

Whether you’re looking to test raw materials or finished goods, you can be confident that Dyad Labs will provide you with accurate, precise, and timely results.

Being born from manufacturing since 2008, we understand that “ we are a part of your supply chain and quality control program. Together, we are Dyad.

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 3 Capabilities

3 STAGES OF WHERE DYAD CAN BE A PART OF YOUR QUALITY CONTROL PROGRAM

1. Raw Materials ***Verify Suppliers C of A

IDENTITY FTIR Assay/Analytical Wet ID

Microbials Allergens ICP-MS PURITY UPLC, LC MS/MS, GC, Elemental/Toxicity Pesticides/Residual Solvents GC/MS/MS Liquid Chromatography/Gas STRENGTH Assay/Analytical Chromatography 2. Finished Product Testing *** Verify Label Claim of Product

Microbials Allergens UPLC, LC MS/MS, GC PURITY Elemental/Toxicity Liquid Chromatography GC

STRENGTH Assay/Analytical Liquid Chromatography GC

COMPOSITION Assay/Analytical Liquid Chromatography GC

CONTAMINENTS Assay/Analytical Liquid Chromatography GC

3. Stability Testing Enables Manufacturers to establish Expiration date of Product *** New products are encourage to have atleast 6 months of data

ACCELERATED STABILITY REAL TIME STABILITY Liquid Liquid Analytical Assay/Analytical Chromatography Chromatography Gas STRENGTH Microbials Chromatography Microbiology Pesticides/Residual Microbials Elemental/Toxicity Solvents PURITY Elemental/Toxicity ICP-MS, LC MS/MS GC MS Pesticides/Residual GC Solvents

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 4 Capabilities – Chromatography

POTENCY TESTING VIA LIQUID CHROMATOGRAPHY

Verification of potency claims by liquid chromatography is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. Dyad Labs utilizes compendial methods, AOAC validated test methods and analytical methods developed by Dyad through its years of experience in product testing.

ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Ultra-high performance liquid chromatography (UPLC) has evolved from high performance liquid chromatography (HPLC). Both techniques involve liquid chromatography used to separate the components from mixtures. UPLC differs from HPLC because smaller particle size columns are used. With smaller-particles sizes, there is increased pressure and the instrumentation itself is designed to allow for that. Smaller particle sizes allow for increased chromatographic efficiency and therefore a better and more resolved separation of peaks. With narrower peak shapes, run time can be decreased. All nine of our chromatographic systems at Dyad utilize UPLC instead of HPLC. Assays that we conduct with UPLC/UV detection include:

|| Amino acids || and related compounds || Water-soluble || Organic acids || -soluble vitamins || Alkaloids (already referenced in water soluble section) || Caffeine, theophylline, theobromine, , theacrine, BHB || Curcuminoids, ginsenosides, resveratrol

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 5 Capabilities – Chromatography

LC/MS/MS

LC/MS/MS combines the separation of components using liquid chromatography with the detection specificity of mass spectrometry. With all of the matrices we analyze and the complexity of them, this is a powerful technique. Compared to HPLC & UPLC, LC MS/MS’s added specificity is especially critical in analysis of finished good with low concentrations of compounds, although raw materials can be analyzed just as well. Combined with the specificity, because of the added sensitivity, samples can be diluted relatively more than occurs using UV detection, thus allowing mitigation of sample matrix problems. Some of the assays we analyze on these instruments include:

|| identification (whey, casein, pea, soy, ) || Methyl and || Melamine || Low concentrated water-soluble vitamins || Fat-soluble vitamins (Vitamins D2, D3, K1, and K2: menaquinone-4 and -7)

Turn around times are from 5 - 7 Business Days

Rushes are accepted by a case by case basis

WE OFFER ANALYSIS OF MORE THAN 350 COMPOUNDS USING MORE THAN 50 ASSAYS. OUR INSTRUMENTATION INCLUDES:

|| LC/MS/MS || UPLC || PDA/UV/QDA || GC/MS/MS - coming 4th quarter of 2018 || GC/FID - coming 4th quarter of 2018

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 6 Capabilities – Chromatography

POTENCY TESTING VIA LIQUID CHROMATOGRAPHY

Test Packages Reportable Compounds Turn around Times Histidine, , , Serine, , Glycine, As- partic Acid, Citrulline, Glutamic Acid, Beta Alanine, Threonine, Free Amino Acids Alanine, Theanine, Proline, Cystine, Lysine, Tyrosine, Methi- 7 days onine, Valine, Norvaline, Isoleucine, Leucine, Phyenylalanine, Tryptophan Package (UPLC) , , , Niacinamide, 7 days Thiamine, Riboflavin, Niacin, Niacinamide, Pyridoxine, Pyri- B Vitamins Package (LC-MS/MS) 7 days doxal-5’-phosphate Aflatoxins B1, B2, G1, G2 7 days

UPLC & LC/MS/MS

5-Methyltetrahydrofolic Acid+A44:E49 Pantothenic Acid alpha-Ketoglutaric Acid Citrulline Pyridoxal-5’-Phosphate alpha-Ketoglutaric Acid (on dried basis) Cyanocobalamin Pyridoxine Arginine Pyridoxine HCI Arginine (on dried basis) Folic Acid Riboflavin Fructose Sucrose Ca-5-Methyltetrahydrofolate Glucose Theacrine Caffeine Thiamine Calcium Pantothenate Niacin Thiamine HCl Niacinamide

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 7 Capabilities – Chromatography

LC MS/MS

5-Methyltetrahydrofolic Acid Cyanocobalamin Niacinamide Aflatoxin B1 ECG Dimer Ochratoxin A Aflatoxin B2 ECGC Dimer-1 Pantothenic Acid Aflatoxin G1 ECGC Dimer-2 Pea Protein Aflatoxin G2 Ergocalciferol Phylloquinone Aflatoxins - Total B1, B2, G1, G2 Folic Acid Pyridoxal-5’-Phosphate Biotin Fructose Pyridoxine Ca-5-Methyltetrahydrofolate Glucose Pyridoxine HCI Calcium Pantothenate Glutaurine Riboflavin Casein Protein Glyphosate Rice Protein Catechin Lactose Soy Protein Catechin Dimer Melamine Sucrose Catechin Dimer Digallate Menaquinone-4 Thiamine Catechin Dimer Gallate Menaquinone-7 Thiamine HCl Catechin Tetramer Methylcobalamin Total Sugars Catechin Trimer Methylcobalamin (on dried basis) Whey Protein Catechin Trimer Gallate Protein Cholecalciferol Niacin

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 8 Capabilities – Chromatography

UPLC

4-Hydroxy-L-Isoleucine Betaine HCL D-alpha- 5-Hydroxytryptophan beta-Tocopherol D-alpha-Tocopherol Acetate Acesulfame K Calcium beta-Hydroxy beta-Methylbutyrate D-alpha-Tocopherol Succinate Acetyl-L- Calcium D-Glucarate delta-Tocopherol Acetyl-L-Carnitine HCI Calcium D-Glucarate tetrahydrate Dicreatine Malate Agmatine Capsaicinoids Dicyandiamide Agmatine Carnitine Disodium Creatine Phosphate Agmatine Sulfate Carnitine HCl DL-alpha-Tocopherol Acetate Ajmalicine Carnitine Tartrate DL-alpha-Tocopherol Succinate Ajmaline Catechins (Total) DMAE Alanine Chlorogenic Acid DMAE Bitartrate Alfalfa EGCG alpha- Choline Bitartrate Epicatechin (EC) alpha-Tocopherol Choline Chloride Epicatechin Gallate (ECG) alpha-Tocopheryl Acetate Citric Acid Erythritol alpha-Tocopheryl Succinate Citrulline Malate Evodiamine alpha- Citrulline Nitrate Forskolin alpha-Yohimbine HCI Coenzyme Q10 Gallocatechin (GC) Corosolic Acid Gallocatechin Gallate (GCG) Arginine alpha-Ketoglutaric Acid Corynanthine gamma-Aminobutyric Acid Arginine Ethyl Ester Creatine gamma-Tocopherol Arginine Ethyl Ester HCl Creatine Ethyl Ester Glucaric Acid Arginine HCl Creatine Ethyl Ester HCI Gluconate Arginine Nitrate Creatine HCI Ascorbic Acid Creatine Monohydrate Glucosamine HCI Ascorbyl Palmitate Creatine Nitrate Glucosamine Sulfate Aspartame Creatine Pyruvate Glucosamine Sulfate 2KCl Aspartic Acid Creatinine Glucosamine Sulfate Chloride BCAAs Creatinol-O-Phosphate Glucuronolactone Beta Alanine Curcumin Glutamic Acid Beta Alanine HCI Creatinol-O-Phosphate Glutamic Acid HCI beta-Hydroxy beta-Methylbutyrate Curcumin Glutamine beta-Hydroxybutyrate Curcuminoids Glycine Betaine Cystine Higenamine

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 9 Capabilities – Chromatography

UPLC, CONT.

Higenamine HCl NADH Serine Histidine NaMethyltyramine alpha-Lipoic Acid Histidine HCI Monohydrate NaMethyltyramine HCI Sodium beta-Hydroxybutyrate Hordenine HCI Nitrate Sucralose Huperzine A N-Methyltyramine HCl Synephrine Hydroxycitric Acid Norvaline Synephrine HCl Hyperoside Oleuropein Tartaric Acid Isoleucine Ornithine Taurine Isoleucine Nitrate Ornithine HCl Theanine Isoquercitrin para-Aminobenzoic Acid Theobromine L-5 Hydroxytryptophan Phenylalanine Theophylline Lactic Acid Picamilon Thiamine Mononitrate L-Dopa Proline Threonine Leucic Acid Pterostilbene Total Ginsenosides Leucic Acid (Ca salt) Pyridoxal-5’-Phosphate monohydrate Total Rhodiola Glycosides Leucine Quercetin Total Rosavins Leucine Nitrate Quercetin Dihydrate Total Lysine Quercitrin Tryptophan Lysine HCl Raspberry Ketone Tyramine Maleic Acid R-beta-Methylphenylethylamine Tyrosine Malic Acid Rebaudioside A Valine Resveratrol Vinburnine Methionine Vincamine Methylliberine Retinol Acetate Vinpocetine Monosodium Glutamate Retinol Palmitate Xylitol N-Acetyl Carnitine Ribose Yohimbine N-Acetyl-L- Rosarin Yohimbine Alkaloids N-Acetyl-L-Glutamine Rosavin Yohimbine HCI N-Acetyl-L-Methionine Rosin Yohimbine HCl Anhydrous N-Acetyl-L-Tyrosine Rutin NAD Salidroside

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 10 Capabilities – Chromatography

POTENCY TESTING VIA GAS CHROMATOGRAPHY

Verification of potency claims by Gas chromatography is a technique in analytical chemistry used to separate, identify, and quantify each component in a mixture. Dyad Labs utilizes compendial methods, AOAC validated test methods and analytical methods developed by Dyad through its years of experience in product testing.

Coming 4th quarter:

|| Pesticides || DHA & EPA || Residual Solvents

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 11 Capabilities – Inorganic Chemistry

PURITY TESTING VIA INORGANIC

For analysis of heavy metals and minerals, we have two Agilent 7700 ICP-MS systems (Inductively-coupled plasma mass spectrometry). The ICP source converts the atoms of the elements in the sample to ions by high temperature. These ions are then separated by their mass and detected by the mass spectrometer. This process is highly sensitive, allowing for analysis down to concentrations in the parts-per trillion for some ions. The technology is reproducible, even when analyzing trace metals. In addition, interference removal and matrix tolerance is a critical part of our approach, which allows us to analyze different sample types. As a result, our customers have an accurate measurement of results, including heavy metal contami- nation and mineral composition.

Reportable Compound Method Turn around Times Heavy Metals Package Arsenic, Cadmium, Lead, Mercury AOAC 993.14 5 days Calcium, , , , , , , , , Potassium, Minerals Package 5 days Sodium, Tungsten, , Boron, Lithium, Nickel, Tin, Antimony, Strontium, Tungsten (W) Zinc (Zn) (on dried basis) Indium (In) Vanadium (V) Iron (Fe) Iron (Fe) on dried basis Zinc (Zn) Aluminum (Al) Lead (Pb) Antimony (Sb) AOAC 993.14 5 days Lithium (Li) Magnesium (Mg) Magnesium (Mg) on dried basis Arsenic (As) Manganese (Mn) Manganese (Mn) on dried basis Barium (Ba) Molybdenum (Mo) Tin (Sn)

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 12 Capabilities – Inorganic Chemistry

PURITY TESTING VIA INORGANIC, CONT.

Reportable Compound Method Turn around Times Boron (B) Nickel (Ni) Boron (B) on dried basis Cadmium (Cd) Calcium (Ca) Chromium (Cr) Chromium (Cr) on dried basis Calcium (Ca) on dried basis Cobalt (Co) AOAC 993.14 5 days Copper (Cu) Phosphorus (P) Phosphorus (P) on dried basis Potassium (K) on dried basis Potassium (K) Selenium (Se) Sodium (Na) Sodium (Na) on dried basis Strontium (Sr) Mercury (Hg) DMA 5 days

RUSH SERVICE AVAILABLE 1-3 DAYS

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 13 Capabilities – General Chemistry

IDENTITY TESTING VIA GENERL CHEMISTRY

We offer testing on more than 100 different compounds using more than 20 different types of testing. Our instrumentation is extensive to cover all of this.

Testing includes:

|| FTIR (identification; primarily for raw materials) || Wet chemistry identification

ASSAY / ANALYTICAL TESTING VIA GENERL CHEMISTRY

|| via nitrogen testing (Kjeldahl: Foss Kjeltec and Dumas: Leco TruMac) || Mercury (using Milestone DMA-80) || Fiber (Total using Ankom’s Fiber Analyzer) || Fat (using acid on Foss Hydrotec/Soxtec) || Karl-Fischer || Loss on Drying || Particle size distribution || Bulk/Tap || Water Activity || pH || Ash || Specific gravity || Viscosity || Titrations || Gluten and soy allergens || Calories and (by calculation)

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 14 Capabilities – General Chemistry

IDENTITY / POTENCY / PURITY TESTING VIA GENERL CHEMISTRY

Type Method Reportable Compound Lead Time Ash USP <281>/GL-588 Ash 5 days Bulk Density USP <616>/GL-587 Bulk Density 5 days Density USP <699> Density of Solids 5 days DMA EPA 7473/GL-585 Mercury (Hg) 5 days FTIR USP <197>/GL-511 Standard 2 days Karl Fischer USP <921>/GL-578 Water Content 5 days Loss on Drying USP <731>/GL-516 Loss on Drying 2 days Loss on Drying USP <731>/GL-517 Loss on Drying 6 days Loss on Ignition Current USP-NF Loss on Ignition 5 days Nitrogen / Kjeldhal AOAC 2001.11/GL-542 Nitrogen 5 days Nitrogen / Dumas AOAC 2001.11/GL-542 Protein 5 days Organoleptic GL-552 Physical Stability 10 days Particle Size Distribution USP <786>/GL-566 60 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 80 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 120 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 100 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 200 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 230 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 325 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 40 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 20 Mesh Residue 5 days Particle Size Distribution USP <786>/GL-566 140 Mesh Residue 5 days pH USP <791>/GL-563 pH 5 days Specific Gravity USP <841> Specific Gravity 5 days Tapped Density USP <616>/GL-586 Tapped Density 5 days Titration Current FCC Iron (Fe) 10 days Titration Current FCC Dextrose 10 days Titration Current FCC Dextrose (on dried basis) 10 days Titration Current USP-NF Dextrose Equivalent 10 days Titration Current USP-NF Fumaric Acid 10 days Total Solids Current USP-NF Total Solids 5 days

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 15 Capabilities – General Chemistry

IDENTITY / POTENCY / PURITY TESTING VIA GENERL CHEMISTRY

Type Method Reportable Compound Lead Time Water Activity AquaLab/GL-518 Water Activity 3 days Wet ID FCC Monograph Cellulose Gum 5 days Titration Current USP-NF Lactic Acid 10 days Titration Current USP-NF Standard 10 days Titration Current USP-NF Potassium Iodide 10 days Titration Current USP-NF Boric Acid 10 days Titration Current USP-NF Potassium Citrate 10 days * Wet ID Current USP-NF Guar Gum 5 days Wet ID Current USP-NF Acacia 5 days Wet ID Current USP-NF Acetate 5 days Wet ID Current USP-NF Titanium Dioxide 5 days Wet ID Current USP-NF Hypophosphite 5 days Wet ID Current USP-NF Iodide 5 days Wet ID Current USP-NF Iron (Fe) 5 days Wet ID Current USP-NF Iron Phosphate 5 days Wet ID Current USP-NF Lactate 5 days Wet ID Current USP-NF Zinc (Zn) 5 days Wet ID Current USP-NF 5 days Wet ID Current USP-NF Zinc Oxide 5 days Wet ID Current USP-NF Aluminum (Al) 5 days Wet ID Current USP-NF Ammonium 5 days Wet ID Current USP-NF Antimony (Sb) 5 days Wet ID Current USP-NF Lithium (Li) 5 days Wet ID Current USP-NF Magnesium (Mg) 5 days Wet ID Current USP-NF Magnesium Oxide 5 days Wet ID Current USP-NF Magnesium Phosphate 5 days Wet ID Current USP-NF Manganese (Mn) 5 days Wet ID Current USP-NF Calcium Carbonate 5 days Wet ID Current USP-NF Barium (Ba) 5 days Wet ID Current USP-NF Calcium Citrate 5 days Wet ID Current USP-NF Benzoate 5 days Wet ID Current USP-NF Calcium Lactate 5 days

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 16 Capabilities – General Chemistry

IDENTITY / POTENCY / PURITY TESTING VIA GENERL CHEMISTRY

Type Method Reportable Compound Lead Time Wet ID Current USP-NF Calcium Phosphate 5 days Wet ID Current USP-NF Carrageenan 5 days Wet ID Current USP-NF Bicarbonate 5 days Wet ID Current USP-NF Carbonate 5 days Wet ID Current USP-NF Pullulan 5 days Wet ID Current USP-NF Bismuth 5 days Wet ID Current USP-NF Bisulfite 5 days Wet ID Current USP-NF Bitartrate 5 days Wet ID Current USP-NF Borate 5 days Wet ID Current USP-NF Chlorate 5 days Wet ID Current USP-NF Chloride 5 days Wet ID Current USP-NF 5 days Wet ID Current USP-NF Nitrite 5 days Wet ID Current USP-NF Chromic Chloride 5 days Wet ID Current USP-NF Calcium (Ca) 5 days Wet ID Current USP-NF Chromium Picolinate 5 days Wet ID Current USP-NF Calcium Ascorbate 5 days Wet ID Current USP-NF Citrate 5 days Wet ID Current USP-NF Oxalate 5 days Wet ID Current USP-NF Permanganate 5 days Wet ID Current USP-NF Peroxide 5 days Wet ID Current USP-NF Cobalt (Co) 5 days Wet ID Current USP-NF Standard 5 days Wet ID Current USP-NF Milk Thistle 5 days Wet ID Current USP-NF Phosphate 5 days Wet ID Current USP-NF Copper (Cu) 5 days Wet ID Current USP-NF 5 days Wet ID Current USP-NF Potassium (K) 5 days Wet ID Current USP-NF Corn Starch 5 days Wet ID Current USP-NF Potassium Bicarbonate 5 days Wet ID Current USP-NF Potassium Phosphate 5 days Wet ID Current USP-NF Potassium Sorbate 5 days Wet ID Current USP-NF Dicalcium Phosphate 5 days

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 17 Capabilities – General Chemistry

IDENTITY / POTENCY / PURITY TESTING VIA GENERL CHEMISTRY

Type Method Reportable Compound Lead Time Wet ID Current USP-NF Dipotassium Phosphate 5 days Wet ID Current USP-NF Disodium Phosphate 5 days Wet ID Current USP-NF Silicon 5 days Wet ID Current USP-NF Silicon Dioxide 5 days Wet ID Current USP-NF Ferric Salts 5 days Wet ID Current USP-NF Ferrous Fumarate 5 days Wet ID Current USP-NF Silver 5 days Wet ID Current USP-NF Ferrous Salts 5 days Wet ID Current USP-NF Sodium (Na) 5 days Wet ID Current USP-NF Sodium Bicarbonate 5 days Wet ID Current USP-NF Sodium Chloride 5 days Wet ID Current USP-NF Sodium Citrate 5 days Wet ID Current USP-NF Gelatin 5 days Wet ID Current USP-NF Xanthan Gum 5 days Wet ID Current USP-NF Sulfate 5 days Wet ID Current USP-NF Sulfite 5 days Wet ID Current USP-NF Thaimine Mononitrate 5 days Wet ID Current FCC Glyceryl Monostearate 5 days Wet ID Current FCC Silicon Dioxide 5 days Wet ID Current FCC Standard 5 days Wet ID Current FCC Maltodextrin 5 days

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 18 Capabilities – Microbiology

MICROBIOLOGY TESTING

No matter where materials and consumables fall into the supply chain, they are constantly being introduced to micro-organisms. Most microbes are harmless but there are some that can damage the human health, product quality, contaminate the environment and irreversibly change a product. Here at Dyad we offer the following Micrbobiology services.

For rapid microbiology testing, we use AOAC-approved Invisible Sentinel Veriflow technology for the detection of Salmonella, Listeria species and many more to come. This new platform utilizes PCR based technology with a much shorter turn-around- time (36-48 hours). Great for food companies who need to know if there products/raws/enviroment contains pathogens.

Type Method Lead Time USP <2021> 3 days FDA BAM 3 days Aerobic Plate Count AOAC 990.12 3 days EP Purified Water 7 days * Bacillus cereus GL-483 4 days FDA BAM 5 days Coliforms AOAC 991.14 3 days FDA BAM 6 days Pathogen / Microbial * E. coli AOAC 991.14 4 days Activity USP <2021> 3 days USP <2021> 4 days * Enterobacteriaceae AOAC 2003.01 3 days General Anaerobic Count Difco Manual 5 days Gran Stain GL-492 3 days FDA BAM 5 days * Listeria 3M Petrifilm 3 days * Pseudomonas aeruginosa USP <62> 4 days

* = pathogens

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 193 Capabilities – Microbiology

MICROBIOLOGY TESTING, CONT.

Type Method Lead Time USP <2022> 4 days * Salmonella FDA BAM 4 days Pathogen / Microbial Invisible Sentinel Veriflow technology 4 days Activity USP <2022> 4 days * Staphylococcus aereus FDA BAM 3 days Water Testing EP Purified Water 7 days AOAC 997.02 6 days AOAC 2014.05 6 days Molds FDA BAM 6 days USP <2021> 6 days AOAC 997.02 6 days AOAC 2014.05 6 days Yeasts FDA BAM 6 days USP (2021> 6 days AOAC 997.02 6 days AOAC 2014.05 6 days Yeasts and Molds FDA BAM 6 days USP <2021> 6 days Viable Count GL-470 7 days (Spores, Yeast, etc.) Probiotic Bacillus coagulans GL-471 7 days acidophilus GL-470 7 days

* = pathogens

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 20 Capabilities

NUTRITIONAL SUPPLEMENT PANEL

Requires minimum of 100g of sample, Full Panel/NLEA

Test Method Sendout TAT (Business Days) Notes Total Fatty Acids GC Yes 10 days Includes Saturated Fat, Trans Fat, Monounsaturated Fat, and Polyunsaturated Fat AOAC Yes 10 days Carbohydrates Calculation No 7 days Includes Ash and Loss on Drying Dietary Fiber AOAC 991.43 No 7 days Sugars LC-MS/MS No 7 days Protein AOAC 2001.11/GL-542 No 7 days LC-MS/MS No 7 days Sodium AOAC 993.14/GL-500 No 5 days Calcium AOAC 993.14/GL-500 No 5 days Potassium AOAC 993.14/GL-500 No 5 days Iron AOAC 993.14/GL-500 No 5 days Total VALC_S Yes 10 days Ascorbic Acid GL-607 No 7 days B Vitamins Package GL-602 No 7 days Includes Niacin, Pyridoxine, Thiamine, Riboflavin

1945 Fremont Drive dyadlabs.com Phone+1.801.973.8824 Salt Lake City, UT 84104 USA [email protected] 21 —

1945 Fremont Drive Salt Lake City, UT 84104 USA

Phone+1.801.973.8824 Print +1.801.973.8800

dyadlabs.com [email protected]