Interactions with Nnrtis Charts Revised May 2018

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Interactions with NNRTIs Charts revised May 2018. Full information available at www.hiv-druginteractions.org Page 1 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

RPV + RPV + EFV ETV NVP RPV F/TAF EFV ETV NVP RPV F/TAF Anaesthetics & Muscle Relaxants Antibacterials (continued) Alcuronium      Ertapenem      Bupivacaine      Erythromycin      Cisatracurium      Ethambutol      Desflurane      Ethionamide      Dexmedetomidine      Flucloxacillin      Enflurane      Gentamicin      Ephedrine      Imipenem/Cilastatin      Halothane      Isoniazid      Isoflurane      Kanamycin      Levofloxacin Ketamine           Linezolid      Nitrous oxide      Meropenem      Propofol      Metronidazole      Rocuronium      Moxifloxacin      Sevoflurane      Nitrofurantoin      Sufentanil      Ofloxacin      Suxamethonium (succinylcholine)      Para-aminosalicylic acid      Tetracaine      Penicillins      Thiopental      Pyrazinamide      Tizanidine      Rifabutin      Vecuronium      Rifampicin      Analgesics Rifapentine      Alfentanil      Rifaximin      Aspirin      Spectinomycin      Buprenorphine      Streptomycin      Celecoxib      Sulfadiazine      Telithromycin Codeine           Tetracyclines      Dextropropoxyphene      Trimethoprim/Sulfamethoxazole      Diamorphine (diacetylmorphine)      Vancomycin      Diclofenac      Dihydrocodeine      Anti-coagulant, Anti-platelet and Fibrinolytic Fentanyl      Acenocoumarol      Hydrocodone      Apixaban      Aspirin (anti-platelet) Hydromorphone           Clopidogrel      Ibuprofen      Dabigatran      Mefenamic acid      Dalteparin      Methadone      Dipyridamole      Morphine      Edoxaban     

Naproxen      distribution. for Not only. use For personal istribution. Eltrombopag      Nimesulide      Enoxaparin      Oxycodone      Fondaparinux      Paracetamol (Acetaminophen)      Heparin      Pethidine (Meperidine)      Phenprocoumon      Piroxicam      Prasugrel      Tramadol      Rivaroxaban      Anthelmintics Streptokinase      Albendazole      Ticagrelor      Diethylcarbamazine      Warfarin      Ivermectin      Anticonvulsants Levamisole (Ergamisol)      Carbamazepine      Mebendazole      Clonazepam      Niclosamide      Ethosuximide      Oxamniquine      Gabapentin     

For personal use only. Not for d Not only. use For personal Lacosamide     

Praziquantel      Pyrantel      Lamotrigine      Suramin sodium      Levetiracetam      Oxcarbazepine      Triclabendazole      Phenobarbital (Phenobarbitone)      Antiarrhythmics Phenytoin      Amiodarone      Pregabalin      Bepridil      Topiramate      Disopyramide      Valproate (Divalproex)      Dofetilide      Vigabatrin      Flecainide      Zonisamide      Lidocaine (Lignocaine)      Antidepressants Mexiletine      Agomelatine      Propafenone      Amitriptyline      Quinidine      Bupropion      Antibacterials Citalopram      Amikacin      Clomipramine      Amoxicillin      Desipramine      Ampicillin      Doxepin      Azithromycin      Duloxetine      Bedaquiline      Escitalopram      Capreomycin      Fluoxetine      Fluvoxamine      Cefalexin      for distribution. Not only. use For personal Cefazolin      Imipramine      Lithium      Cefixime      Maprotiline      Cefotaxime      Mianserine      Ceftazidime      Milnacipran      Ceftriaxone      Mirtazapine      Chloramphenicol      Nefazodone      Ciprofloxacin      Nortriptyline      Clarithromycin      Paroxetine      Clavulanic acid      Phenelzine      Clindamycin      Reboxetine      Clofazimine      Sertraline      Cloxacillin      Tranylcypromine      Cycloserine      Trazodone      Dapsone      Trimipramine      Doxycycline      Venlafaxine     

Key to abbreviations Key to symbols Where advice differs between countries, and/or between boosted and EFV Efavirenz (Sustiva®, Stocrin®)  These drugs should not be coadministered unboosted regimens, the charts reflect the more cautious option. Potential interaction – may require close monitoring, ® ETV Etravirine (Intelence )  alteration of drug dosage or timing of administration © Liverpool Drug Interactions Group, University of Liverpool Potential interaction likely to be of weak intensity. ® Pharmacology Research Labs, 1st Floor Block H, 70 Pembroke Place, LIVERPOOL, L69 3GF NVP Nevirapine (Viramune ) Additional action/monitoring or dosage adjustment is We aim to ensure that information is accurate and consistent with current knowledge unlikely to be required RPV Rilpivirine (Edurant®) and practice. However, the University of Liverpool and its servants or agents shall not  No clinically significant interaction expected be responsible or in any way liable for the continued currency of information in this publication whether arising from negligence or otherwise howsoever or for any RPV + Rilpivirine/Emtricitabine/Tenofovir alafenamide There are no clear data, actual or theoretical, to indicate ®  consequences arising therefrom. The University of Liverpool expressly exclude F/TAF (Odefsey ) whether an interaction will occur liability for errors, omissions or inaccuracies to the fullest extent permitted by law.

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Interactions with NNRTIs Charts revised May 2018. Full information available at www.hiv-druginteractions.org Page 2 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

RPV + RPV + EFV ETV NVP RPV F/TAF EFV ETV NVP RPV F/TAF Anti-diabetics Antipsychotics/Neuroleptics Acarbose      Amisulpride      Empagliflozin      Aripiprazole      Exanatide      Asenapine      Chlorpromazine      Glibenclamide (Glyburide)      Clozapine      Gliclazide      Fluphenazine      Glimepiride      Haloperidol      Glipizide      Iloperidone      Insulin      Levomepromazine      Linagliptin      Olanzapine      Liraglutide      Paliperidone      Perazine      Metformin      Periciazine      Nateglinide      Perphenazine      Pioglitazone      Pimozide      Repaglinide      Pipotiazine      Rosiglitazone      Quetiapine      Saxagliptin      Risperidone      Sitagliptin      Sulpiride      Thioridazine      Tolbutamide      Tiapride      Vildagliptin      Ziprasidone      Antifungals Zotepine      Amphotericin B      Zuclopenthixol      Anidulafungin      Antivirals Caspofungin      Aciclovir      Fluconazole      Adefovir      Flucytosine      Amantadine      Boceprevir      Griseofulvin      Cidofovir      Itraconazole      Daclatasvir      Ketoconazole      Elbasvir/Grazoprevir      Miconazole      Entecavir      Nystatin      Famciclovir      Posaconazole      Foscarnet      Ganciclovir Terbinafine           Glecaprevir/Pibrentasvir     

Voriconazole      distribution. for Not only. use For personal istribution. Ledipasvir/sofosbuvir      Antihistamines Ombitasvir/Paritaprevir/r      Astemizole      Ombitasvir/Paritaprevir/r + Dasabuvir      Cetirizine      Oseltamivir      Chlorphenamine      Ribavirin      Diphenhydramine      Rimantadine      Fexofenadine      Simeprevir      Sofosbuvir      Levocetirizine      Sofosbuvir/Velpatasvir      Loratadine      Sofosbuvir/Velpatasvir/Voxilaprevir      Promethazine      Telaprevir      Terfenadine      Telbivudine      Antimigraine Agents Valaciclovir      Almotriptan      Zanamivir      For personal use only. Not for d Not only. use For personal Dihydroergotamine      Anxiolytics/Hypnotics/ Sedatives Ergotamine      Alprazolam      Bromazepam Rizatriptan           Buspirone      Sumatriptan      Chlordiazepoxide      Antiprotozoals Clorazepate      Amodiaquine      Diazepam      Artemisinin      Estazolam      Atovaquone      Flunitrazepam      Benznidazole      Flurazepam      Hydroxyzine      Chloroquine      Lorazepam      Diloxanide      Lormetazepam      Eflornithine      Midazolam (oral)      Halofantrine      Midazolam (parenteral)      Lumefantrine      Oxazepam      Mefloquine      Temazepam      Triazolam      Meglumine antimoniate      Zaleplon      Melarsoprol      Zolpidem      Miltefosine      Zopiclone     

Nifurtimox      for distribution. Not only. use For personal Beta Blockers Paromomycin      Atenolol      Pentamidine      Bisoprolol      Primaquine      Carvedilol      Metoprolol Proguanil           Nebivolol      Pyrimethamine      Oxprenolol      Quinine      Pindolol      Sodium stibogluconate      Propranolol      Sulfadoxine      Timolol     

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Interactions with NNRTIs Charts revised May 2018. Full information available at www.hiv-druginteractions.org Page 3 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

RPV + RPV + EFV ETV NVP RPV F/TAF EFV ETV NVP RPV F/TAF Bronchodilators Cytotoxics (continued) Aclidinium bromide      Mercaptopurine      Aminophylline      Mesna      Formoterol      Methotrexate      Glycopyrronium bromide      Mitoxantrone      Indacaterol      Nilotinib      Ipratropium bromide      Oxaliplatin      Montelukast      Paclitaxel      Olodaterol      Pazopanib      Roflumilast      Procarbazine      Salbutamol      Rituximab      Salmeterol      Sorafenib      Theophylline      Sunitinib      Tiotropium bromide      Tamoxifen      Umeclidinium bromide      Temsirolimus      Vilanterol      Topotecan      Toremifene      Calcium Channel Blockers Vinblastine      Amlodipine      Vincristine      Diltiazem      Vorinostat      Felodipine      Erectile Dysfunctional Agents Nicardipine      Sildenafil (Erectile Dysfunction)      Nifedipine      Tadalafil (Erectile Dysfunction)      Nisoldipine      Vardenafil      Nitrendipine      Gastrointestinal Agents Verapamil      Alosetron      Contraceptives/HRT Antacids      Desogestrel (COC)      Bisacodyl      Desogestrel (POP)      Cimetidine      Drospirenone (COC)      Cisapride      Drospirenone (HRT)      Esomeprazole      Dydrogesterone (HRT)      Famotidine      Estradiol      Lactulose      Ethinylestradiol      Lansoprazole      Etonogestrel (implant)      Loperamide      Etonogestrel (vaginal ring)      Mesalazine      Gestodene (COC)      Omeprazole      Levonorgestrel (COC)      Pantoprazole     

Levonorgestrel (emergency contraception)      distribution. for Not only. use For personal istribution. Prucalopride      Levonorgestrel (HRT)      Rabeprazole      Levonorgestrel (implant)      Ranitidine      Levonorgestrel (IUD)      Senna      Levonorgestrel (POP)      Gastrointestinal Agents (anti-emetics) Medroxyprogesterone (depot injection)      Aprepitant      Medroxyprogesterone (oral)      Dolasetron      Norelgestromin (patch)      Domperidone      Norethisterone [Norethindrone] (COC)      Dronabinol      Norethisterone [Norethindrone] (HRT)      Granisetron      Norethisterone [Norethindrone] (IM depot)      Metoclopramide      Norethisterone [Norethindrone] (POP)      Ondansetron      Prochlorperazine      Norgestimate (COC)      Norgestrel (COC)      Herbals/Supplements/Vitamins African potato      Norgestrel (HRT)      for d Not only. use For personal

Ulipristal      Aloe vera      Ascorbic Acid (vitamin C)      Cytotoxics Calcium supplements      Anastrozole      Cat’s claw (Uncaria tomentosa)      Asparaginase      Colecalciferol (vitamin D3)      Bexarotene      Cubeb pepper (Piper cubeba)      Bleomycin      Cyanocobalamin      Bortezomib      Echinacea      Capecitabine      Eucalyptus globulus      Carboplatin      Folic acid      Chlorambucil      Garlic      Cisplatin      Ginger (Zinigiber officinale)      Cyclophosphamide      Ginkgo biloba      Cytarabine      Goldenseal root (Hydrastis canadensis)      Dacarbazine      Grapefruit juice      Dactinomycin      Hops (Humulus lupulus)      Dasatinib      Inula racemosa      Daunorubicin      Iodine      Docetaxel      Iron supplements      Doxorubicin      Liquorice (Glycyrrhiza glabra)      Magnesium supplements      Droloxifene      For personal use only. Not for distribution. for distribution. Not only. use For personal Malabar nut tree      Epirubicin      Menthol      Erlotinib      Milk thistle      Estramustine      Multivitamins      Etoposide      Nicotinamide      Everolimus      Phytomenadione (vitamin K)      Exemestane      Pyridoxine (vitamin B6)      Fludarabine      Quercetin      Fluorouracil      Retinol (vitamin A)      Formestane      Riboflavin (vitamin B2)      Gefitinib      Saw palmetto (Serenoa repens)      Gemcitabine      Seville orange juice      Ifosfamide      St John's Wort      Imatinib      Thiamine (vitamin B1)      Irinotecan      Turmeric (Curcuma longa)      Lapatanib      Valerian      Letrozole      Vitamin E     

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Interactions with NNRTIs Charts revised May 2018. Full information available at www.hiv-druginteractions.org Page 4 of 4 Please note that if a drug is not listed it cannot automatically be assumed it is safe to coadminister.

RPV + RPV + EFV ETV NVP RPV F/TAF EFV ETV NVP RPV F/TAF Hypertension / Heart Failure Agents Other Aliskiren      Acetazolamide      Ambrisentan      Acitretin      Amiloride      Adrenaline (Epinephrine)      Bendroflumethiazide      Alendronic Acid      Bosentan      Alfuzosin      Candesartan      Allopurinol      Captopril      Atropine      Chlortalidone      Baclofen      Cilazapril      Biperiden      Clonidine      Caffeine citrate      Digoxin      Carbimazole     

Dopamine      Clomifene Doxazosin           Enalapril      Colchicine      Eplerenone      Cyproterone acetate      Epoprostenol      Denosumab      Eprosartan      Disulfiram      Furosemide      Dutasteride      Hydralazine      Finasteride      Hydrochlorothiazide      Flibanserin      Iloprost      Goserelin      Indapamide      Ibandronic acid      Irbesartan      Isotretinoin      Isosorbide dinitrate      Leuprorelin      Ivabradine      Levothyroxine      Labetalol      Magnesium      Lacidipine      Mannitol      Lercanidipine      Methylphenidate      Lisinopril      Modafinil      Losartan      Naftidrofuryl      Macitentan      Naltrexone      Methyldopa      Neostigmine      Metolazone      Nicorandil      Olmesartan      Orlistat      Perindopril      Penicillamine Prazosin           Quinapril      Pentoxifylline      Ramipril      Pilocarpine      Ranolazine      Potassium      Riociguat      distribution. for Not only. use For personal istribution. Probenecid      Sacubitril      Propylthiouracil      Selexipag      Protamine sulphate      Sildenafil (PAH)      Pyridostigmine      Sodium nitroprusside      Strontium ranelate      Spironolactone      Sulfasalazine      Tadalafil (PAH)      Tamsulosin      Telmisartan      Thalidomide      Terazosin      Tranexamic acid      Torasemide      Varenicline      Trandolapril      Zoledronic acid      Treprostinil      Overactive Bladder Agents Valsartan      Darifenacin      Xipamide      Fesoterodine      Illicit/Recreational Mirabegron      For personal use only. Not for d Not only. use For personal Alcohol      Oxybutynin      Amphetamine      Solifenacin      Cannabis      Tolterodine      Cocaine      Trospium      Ecstasy (MDMA)      GHB (Gamma-hydroxybutyrate_      Oxytocics Heroin      Ergometrine (Ergonovine)      LSD (Lysergic acid diethylamide)      Mifepristone      Mephedrone      Misoprostol      Methamphetamine      Oxytocin      Phencyclidine (PCP)      Parkinsonism Agents Poppers(Amyl nitrate)      Apomorphine      Immune Modulators Benserazide      Hydroxyurea (Hydroxycarbamide)      Carbidopa      Interferon alpha      Levodopa      Interleukin 2 (Aldesleukin)      Pramipexole      Peginterferon alfa-2a      Rasagiline      Immunosuppressants Ropinirole      Anti-thymocyte globulin      Steroids Azathioprine      Beclometasone      Basiliximab      Betamethasone      Belatacept     

For personal use only. Not for distribution. for distribution. Not only. use For personal Budesonide      Ciclosporin      Clobetasol      Mycophenolate      Dexamethasone      Sirolimus      Fludrocortisone      Tacrolimus      Fluocinolone      Lipid Lowering Agents Fluticasone      Atorvastatin      Hydrocortisone (oral)      Bezafibrate      Hydrocortisone (topical)      Clofibrate      Megestrol acetate      Ezetimibe      Methylprednisolone      Fenofibrate      Fish oils      Mometasone      Fluvastatin      Nandrolone      Gemfibrozil      Oxandrolone      Lovastatin      Prednisolone      Pitavastatin      Prednisone      Pravastatin      Stanazolol      Rosuvastatin      Testosterone      Simvastatin      Triamcinolone     