Immune Checkpoint Inhibitors

Much of the recent advancement in the field of tumor immunology and immunotherapy has been generated by the recognition that immune checkpoint proteins can be blocked by human antibodies. Immune checkpoint pathways involve both costimulatory and inhibitory proteins. The costimulatory receptors transduce signals to promote immunity against pathogens. The inhibitory receptors, on the other hand, negatively regulate T- cell activation to prevent excessive inflammation. Immunomodulatory antibodies directed against cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1), have demonstrated significant promise in the treatment of melanoma and other tumor types. These agents are commonly called “checkpoint inhibitors” because they block normally negative regulators of T cell immunity. Numerous other immune checkpoint pathways that could be the target of novel therapies have been identified and are currently under development for clinical testing. BioVision offers a comprehensive collection of immune checkpoint proteins and antibodies to support immune checkpoint blockade research. These products have demonstrated consistent and excellent performance in a variety of assays. Immune Checkpoint Inhibitors

Product Name Cat. No. Size CAS No. A77 1726 1973 5 mg, 25 mg 108605-62-5 Ascomycin 1573 2 mg 104987-12-4 Azathioprine 9536 100 mg, 500 mg 446-86-6 AZD-4635 B2012 5 mg, 25 mg 1321514-06-0 Busulfan B1063 1 g, 5 g 55-98-1 CPI-444 B1970 5 mg, 25 mg 1202402-40-1 Cyclophosphamide monohydrate 9657 1 g, 5 g 6055-19-2 Cyclosporine A 1522 100 mg, 1 g 59865-13-3 Fingolimod (FTY-720A, FTY720) 1618 5 mg, 25 mg 162359-56-0 FK-506 1563 1 mg, 10 mg 104987-11-3 GSK-J4 hydrochloride 2259 1 mg, 5 mg N/A GW2580 1740 5 mg, 25 mg 870483-87-7 EZSolution™ GW2580 2549 5 mg 870483-87-7 IDO Pathway inhibitor 2746 50 mg, 250 mg 110117-83- 4 IDO1 Inhibitor I 2745 5 mg, 25 mg 914471-09-3 INCB-024360 9477 5 mg, 25 mg 1204669-58-8 JZL195 B1064 5 mg, 25 mg 1210004-12-8

www.biovision.com 155 S. Milpitas Blvd, Milpitas, CA 95035 T: 408-493-1800 F: 408-493-1801 Toll Free: 800-891-9699 (US Only) Immune Checkpoint Inhibitors Product Name Cat. No. Size CAS No. Laquinimod 2332 5 mg, 25 mg 248282-07-7 Leflunomide 1972 10 mg, 50 mg 75706-12-6 Maraviroc B2044 5 mg, 25 mg 376348-65-1 6-Mercaptopurine (monohydrate) B2039 50 mg, 250 mg 50-44-2 ML243 2515 5 mg, 25 mg 1426576-80-8 MX69 B1568 5 mg, 25 mg 1005264-47-0 Mycophenolic Acid 1882 50 mg, 250 mg 24280-93-1 Myriocin (ISP-1) 2567 5 mg, 25 mg 35891-70-4 NLG919 9407 5 mg, 25 mg 1402836-58-1 PD-1/PD-L1 Inhibitor 1 B1213 5 mg, 25 mg 1675201-83-8 PD-1/PD-L1 Inhibitor 2 B1050 5 mg, 25 mg 1675203-84-5 Pomalidomide B1811 5 mg, 25 mg 19171-19-8 (R,S)-Lenalidomide 1862 25 mg, 100 mg 191732-72-6 EZSolution™ (R,S)-Lenalidomide B1503 10 mg 191732-72-6 Rocaglamide 1863 100 µg 84573-16-0 SCH-58261 B1638 5 mg, 25 mg 160098-96-4 TAPI-0 2067 1 mg 143457-40-3 TAPI-1 2068 1 mg 171235-71-5 EZSolution™ TAPI-1 2537 1 mg 171235-71-5 TAPI-2 2069 1 mg 187034-31-7 Tasquinimod B2855 5 mg, 25 mg 254964-60-8 (±)-Thalidomide 2020 10 mg, 50 mg 50-35-1 Vidofludimus B1633 5 mg, 25 mg 717824-30-1 Zotarolimus 9530 1 mg, 5 mg 221877-54-9 PD-L1 Binding Ligand

Product Name Cat. No. Size CAS No. WL12 B2586 500 µg, 1 mg NA

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