Figure e-1. Review strategy and compiled articles Unfiltered Search results Exclusions Inclusions “antibiotics” and “seizures”: 282 articles 127 pediatric studies 85 not theme related 35 animal studies 24 reviews 9 not antibiotics in general 2 articles not in English “antibiotics” and “status epileptics”: 25 articles 10 pediatric studies 8 not theme related 2 articles 3 not antibiotics in general 1 review 1 article not in English “penicillin” and “seizures” 340 articles 252 animal studies 35 pediatric studies 2 articles 28 reviews 12 not theme related 1 related to other drugs 1 article not in English “penicillin” and “status epilepticus”: 21 articles 15 animal studies 4 not theme related 2 articles not in English “amoxicillin/cl.” and “seizures”: 1 article 1 related to other drugs “amoxicillin/cl.” and “status epilepticus”: 0 articles “tazobactam” and “seizures”: 6 articles 3 not theme-related 1 animal study 2 articles “tazobactam” and “status epilepticus”: 1 article No exclusions 1 article “cefazolin” and “seizures”: 20 articles 11 animal studies 3 not theme related 4 articles 2 pediatric studies “cefazolin” and “status epilepticus”: 4 articles 1 animal studies 1 not theme related 2 articles “cefotiam” and “seizures”: 2 articles 1 not theme-related 1 article “cefotiam” and “status epilepticus”: 0 articles “cefixime” and “seizures”: 0 articles “cefixime” and “status epilepticus”: 0 articles “ceftriaxon” and “seizures”: 1 articles 1 article not in English “ceftriaxon” and “status epilepticus”: 0 articles “ceftazidime” and “seizures”: 24 articles 9 pediatric studies 8 not theme related 4 reviews 3 related to other drugs “ceftazidime” and “status epilepticus”: 6 articles 1 not theme-related 2 related to other drugs 3 articles “cefepime” and “seizures”: 17 articles 11 pediatric studies 4 not theme related 1 article 1 review “cefepime” and “status epilepticus”: 21 articles 6 pediatric studies 3 not theme related 9 articles 2 articles not in English “imipenem” and “seizures”: 89 articles 36 not theme-related 14 pediatric studies 8 articles 13 reviews 12 animal studies 6 related to other drugs “imipenem” and “status epilepticus”: 1 article 1 article not in English “meropenem” and “seizures”: 67 articles 22 not theme-related 10 pediatric studies 5 articles 14 reviews 8 related to other drugs 4 animal studies 2 duplicates 2 articles not in English 65 articles included “meropenem” and “status epilepticus”: 4 articles 3 not theme-related 1 related to other drugs & 78 additional “doripenem” and “seizures”: 10 articles 9 not theme-related 1 review 1 article articles from “doripenem” and “status epilepticus”: 0 articles reference lists “ertapenem” and “seizures”: 12 articles 3 not theme-related 3 reviews 5 articles 1 pediatric study “doripenem” and “status epilepticus”: 1 article No exclusions 1 article 25712 patients “ciprofloxacin” and “seizures”: 33 articles 14 not theme-related 7 animal study 6 articles 3 related to other drugs 3 reviews “ciprofloxacin” and “status epilepticus”: 2 articles 1 not theme-related 1 article “norfloxacin” and “seizures”: 14 articles 3 not theme-related 1 review 1 article 9 animal study “norfloxacin” and “status epilepticus”: 0 articles No exclusions “levofloxacin” and “seizures”: 7 articles 2 reviews 2 animal study 2 articles 1 not theme-related “levofloxacin” and “status epilepticus”: 3 articles 2 not theme-related 1 article “moxifloxacin” and “seizures”: 2 articles 1 not theme-related 1 article “moxifloxacin” and “status epilepticus”: 1 article No exclusions 1 article “gatifloxacin” and “seizures”: 5 articles 2 related to other drugs 1 review 1 article 1 animal study “gatifloxacin” and “status epilepticus”: 2 articles 1 article not in English 1 article “alatrofloxacin” and “seizures”: 1 article No exclusions 1 article “alatrofloxacin” and “status epilepticus”: 0 articles “amikacin” and “seizures”: 3 articles 2 not theme-related 1 related to other drugs “amikacin” and “status epilepticus”: 0 articles “gentamycin” and “seizures”: 0 articles “gentamycin” and “status epilepticus”: 0 articles “tobramycin” and “seizures”: 2 articles 2 not theme-related “tobramycin” and “status epilepticus”: 1 article 1 not theme-related “vancomycin” and “seizures”: 17 articles 13 not theme-related 2 animal study 1 review 1 related to other drugs “vancomycin” and “status epilepticus”: 1 article 1 not theme-related “teicoplanin” and “seizures”: 4 articles 2 not theme-related 2 animal study “teicoplanin” and “status epilepticus”: 1 articles 1 related to other drugs “daptomycin” and “seizures”: 0 articles “daptomycin” and “status epilepticus”: 0 articles “doxycycline” and “seizures”: 4 articles 4 not theme-related “doxycycline” and “status epilepticus”: 4 articles 4 not theme-related “tigecycline” and “seizures”: 0 articles “tigecycline” and “status epilepticus”: 0 articles “clarithromycin” and “seizures”: 2 articles 2 not theme-related “clarithromycin” and “status epilepticus”: 2 articles 1 not theme-related 1 article “erythromycin” and “seizures”: 10 articles 6 not theme-related 2 related to other drugs 1 article 1 review “erythromycin” and “status epilepticus”: 1 article 1 related to other drugs “azitromycin” and “seizures”: 0 articles “azitromycin” and “status epilepticus”: 0 articles