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Suzanne Pfeffer
July 2010 ASBMB PreSidentiAl PriMer: Suzanne Pfeffer American Society for Biochemistry and Molecular Biology AAdjuvdjuvAAntnt IImmunothermmunotherAApypy ususIIngng KKrnrn70007000 KRN7000 (α-Galactosyl Ceramide) Avanti Number 867000 Supplier: Funakoshi Co. Ltd. Hepatic metastasis is a major clinical problem in cancer treatment. We examined antitumor ac- tivity of alpha-galactosylceramide (KRN7000) on mice with spontaneous liver metastases of re- ticulum cell sarcoma M5076 tumor cells (spontaneous metastasis model). In this model, all mice that were s.c. challenged with one million tumor cells developed a solid s.c. mass by day 7 and died of hepatic metastases. In the current study, we administered 100 microg/kg of KRN7000 to the model mice on days 7, 11, and 15. This treatment suppressed the growth of established liver metastases and resulted in the prolongation of survival time. Fluorescence-activated cell sorter analysis of phenotypes of spleen cells, hepatic lymphocytes, and regional lymph node cells around the s.c. tumor revealed that CD3+NK1.1+ (NKT) cells increased in hepatic lym- phocytes of the KRN7000-treated mice. Cytotoxic activity and IFN-gamma production of hepatic lymphocytes were augmented in comparison with those of spleen cells and regional LN cells. At the same time, interleukin (IL)-12 production of hepatic lymphocytes was markedly enhanced. Neutralization of IL-12 using a blocking monoclonal antibody diminished the prolonged survival time. These results showed that the in vivo antitumor effects of KRN7000 on spontaneous liver metastases were dependent on the endogenous IL-12 production, where NKT cells in the liver are suggested to be involved. Adjuvant immunotherapy using KRN7000 could be a promising modality for the prevention of postoperative liver metastases. -
NIH Conflict of Interest Regs Revised
OCTOBEROCTOBER 2005 www.asbmb.org Constituent Society of FASEB AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY NIH Conflict of Interest Regs Revised SEE PAGE 30 FOR NEW CLARA BENSON TRAVEL FELLOWSHIP AWARD Held in conjunction with EB2006 Custom Antibodies Your Way! Choose the protocol that is right for you! QwikScreen ™: 65 day, 2 rabbit protocol - 4 immunizations, 3 bleeds/rabbit (~100ml serum), customer supplied peptide/protein - Options: Peptide synthesis, immunograde Conjugation to carrier u ELISA u u Animal extensionsMS analysis $685 Standard: 80 day, 2 rabbit protocol - 5 immunizations, 5 bleeds/rabbit (~ 200ml ser Options: um), ELISA, customer supplied peptide/pr Peptide synthesis MS Check™ peptide sequence confirmation u HPLC purified peptide Affinity purification otein - Pinnacle: $975 u HPLC and MS analysis u Complete Affinity Purified Protocol- Animal extensions 2 rabbit pr 5 bleeds/rabbitotocol, (~ 200mlepitope serum), design, peptide PhD technical synthesis support, (up to 20mer),5 immunizations, HPLC purified to ~85%, 5+mg peptide to customer, ELISA, evaluation period, affinity purification, and morMS Check™ peptide sequence confirmationNo Hidden Charges! e… - Discounts for Multiple Protocols$1795 , Includes peptide sequencing by CID MS/MS– u Guaranteed Peptide Let our enthusiasm for scienceExpert workTechnical for SupportFidelity! P: 508.303.8222 www.21stcenturybio.com Toll-free: 877.217.8238 F: 508.303.8333 you! E: [email protected] www.asbmb.org AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY OCTOBER -
Giant Gene Thieves Have You Renewed Your Membership for 2020?
Vol. 18 / No. 10 / November 2019 THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY Giant gene thieves Have you renewed your membership for 2020? Together, we’ll continue to advocate for science, connect researchers around the world and build a bright future for biochemists and molecular biologists everywhere. Learn more at www.asbmb.org/membership CONTENTS NEWS FEATURES PERSPECTIVES 2 24 50 GIANT GENE THIEVES SERVICE BEYOND SCIENCE EDITOR’S NOTE ese viruses are changing what we know Weaving social innovation and scienti c It’s about time about structural and evolutionary biology methods for a bright future 3 32 MEMBER UPDATE MEET SEAN DAVIDSON 7 e JLR associate editor rethinks cholesterol NEW MEMBERS 9 24 YEAR OF (BIO)CHEMICAL ELEMENTS For November, it’s that smell of sulfur 10 NEWS Bacterial invasion may explain recurrent urinary tract infections 11 13 JOURNAL NEWS 11 Snug as a bug in the mud 50 13 Researchers clock DNA’s recovery time 14 Lack of sleep a ects fat metabolism 15 is protein makes antibody drugs work 16 From the journals 22 LIPID NEWS Phospholipids and innate immunity 32 2020 Award Winners … page 37 Ruth Kirschstein Diversity in Science Award: ASBMB Award for Exemplary Contributions to Lizabeth Allison Education: Paul Black Herbert Tabor Research Award: Kevin Campbell Bert and Natalie Vallee Award: Edward Dennis ASBMB–Merck Award: Manajit Hayer–Hartl Alice and C. C. Wang Award in Molecular Parasitology: Patricia Johnson Avanti Award in Lipids: Jean Schaff er Earl and Thressa Stadtman Young Scholar Award: William C. Rose Award: Celia Schiff er David Pagliarini DeLano Award for Computational Biosciences: Mildred Cohn Award in Biological Chemistry: ANNUAL MEETING Yang Zhang Carol Fierke Walter Shaw Young Investigator Award in Lipids: Jeremy Baskin NOVEMBER 2019 ASBMB TODAY 1 EDITOR’S NOTE THE MEMBER MAGAZINE OF THE AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY It’s about time OFFICERS COUNCIL MEMBERS Gerald Hart Suzanne Barbour By Comfort Dorn President Joan Broderick Matt Gentry Toni M. -
Protein Kinase Activation
SEE INSIDE FOR 2008 ANNUAL MEETING SESSION OVERVIEWS July 2007 Protein Kinase Activation American Society for Biochemistry and Molecular Biology POSTDOCTORAL FELLOWSHIP Department of Dermatology, OHSU, Portland, Oregon Training Program in Molecular Basis of Skin Pathobiology Promoting Understanding Position for recent PhD, MD/PhD or MD (US citizen or Permanent Resident) in NIH-funded program for training highly of the Molecular Nature qualifi ed candidates for academic careers in basic & translational research in skin diseases, including cancer & psoriasis. OHSU Dermatology has a strong history of clinical & scientifi c of Life Processes research & a 40-year record in training dermatology residents including physician scientists & postdoctoral scientists on the path to independence. Features of this training program are a core of Dermatology faculty & a multidisciplinary network of scientists with international recognition in areas highly relevant to epithelial cell fate, development & diseases. The training program includes seminars in mentors’ departments, Dermatology Research Division meetings & symposia, research forums tailored to postdoctoral students, & national/international meetings in cutaneous biology. Successful candidates desiring an academic career in basic or translational research in cancer The Society’s purpose is to or investigative dermatology using surface epithelial models can advance the science of bio- expect to receive training toward independence in research with chemistry & molecular biology a strong clinical translational -
CHEMISTRY NEWS UNIVERSITY of OREGON COLLEGE of ARTS and SCIENCES DEPARTMENT of CHEMISTRY 1996 from the DEPARTMENT HEAD the Past Year Was an Exhilarat- Didates
CHEMISTRY NEWS UNIVERSITY OF OREGON COLLEGE OF ARTS AND SCIENCES DEPARTMENT OF CHEMISTRY 1996 FROM THE DEPARTMENT HEAD The past year was an exhilarat- didates. We did something un- ing one for the Department of heard offor Oregon anywaywe Chemistry. Among many exciting requested permission to hire both things that happened, we hired candidates. To our mild surprise, two new faculty members, our the deans office and the Graduate Achievement Endowment Fund School agreed this was an opportu- continues to grow, we honored nity we should not miss. We hired three distinguished alumni with both Andy Marcus and Mark achievement awards, members of Lonergan. Im sure it is obvious our faculty were recognized with that the administration wouldnt national and local awards, and we do this for just any department. It graduated thirty-eight enthusiastic is a sign of our departments undergraduate and graduate stu- strength and quality that we were dents. Let me briefly recount these permitted to hire two new faculty events and achievements. members. Last fall we ran a search for a One of the reasons our depart- physical chemist to replace Warner ment remains optimistic about the Peticolas, who retired. We inter- future is that we have generous viewed four candidates and found alumni who contribute to our © JACK LIU ourselves having to decide be- growing Achievement Endowment tween two absolutely superb can- continued on page 2 Chemistry Commencement Gets Personal Remember when the only and friends. In a new twist this graduation event was a large gath- year, students wrote a humorous ering on a football field? Times script, Our Seniors Top Ten List have changed. -
Hatzios Thesis Formatted
Investigations of Metabolic Pathways in Mycobacterium tuberculosis by Stavroula K Hatzios A dissertation submitted in partial satisfaction of the requirements for the degree of Doctor of Philosophy in Chemistry in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Carolyn R. Bertozzi, Chair Professor Matthew B. Francis Professor Tom Alber Fall 2010 Investigations of Metabolic Pathways in Mycobacterium tuberculosis © 2010 By Stavroula K Hatzios Abstract Investigations of Metabolic Pathways in Mycobacterium tuberculosis by Stavroula K Hatzios Doctor of Philosophy in Chemistry University of California, Berkeley Professor Carolyn R. Bertozzi, Chair Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis in humans, infects roughly two billion people worldwide. However, less than one percent of infected individuals are symptomatic. Most have a latent infection characterized by dormant, non- replicating bacteria that persist within a mass of immune cells in the lung called the granuloma. The granuloma provides a protective barrier between infected cells and surrounding tissue. When host immunity is compromised, the granuloma can deteriorate and reactivate the disease. In order to mount a latent infection, Mtb must survive in alveolar macrophages, the host’s primary line of defense against this intracellular pathogen. By evading typical bactericidal processes, Mtb is able to replicate and stimulate granuloma formation. The mechanisms by which Mtb persists in macrophages are ill defined; thus, elucidating the factors responsible for this hallmark of Mtb pathogenesis is an important area of research. This thesis explores three discrete metabolic pathways in Mtb that are likely to mediate its interactions with host immune cells. The first three chapters examine the sulfate assimilation pathway of Mtb and its regulation by the phosphatase CysQ. -
1968 Commencement Program
UNIVERSITY of PENNSYLVANIA - Two Hundred and Twelfth Commencement for the Conferring of Degrees PHILADELPHIA CIVIC CENTER Monday, May 20, 1968 10:00 A.M. jJ STAGE (1, ......II ,........I " Official Guests Medicine College for Women Graduate Medicine Wharton Law College Nursing Graduate Allied Fine Arts Medical Professions Dental Medicine Veterinary Medicine Wharton Graduate Graduate Arts& Sciences Civil& Mechanical Engineering Chemical Graduate Engineering Education Electrical Engineering Social Work Metallurgy Annenberg Guests will find this diagram helpful in locating the opposite page under Degrees in Course. Reference approximate seating of the degree candidates. The to the paragraph on page seven describing the seating and the order of march in the student pro colors of the candidates' hoods according to their cession correspond closely to the order by school fields of study may further assist guests in placing in which the candidates for degrees are presented. the locations of the various schools. This sequence is shown in the Contents on the Contents Page Seating Diagram of the Graduating Students .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 2 The Commencement Ceremony . 4 Background of the Ceremonies . .. .. .. 6 Degrees in Course . .. .. .. 8 The College of Arts and Sciences . 8 The Engineering Schools . .. .. .. 14 The Towne School of Civil and Mechanical Engineering ... ........ ......... 14 The School of Chemical Engineering . .. .. .. 15 The Moore School of Electrical Engineering . .. 16 The School of Metallurgy and Materials Science . .. .. 18 The Wharton School of Finance and Commerce . 19 The College of Liberal Arts for Women ....... .. ... ...... .. .. .... ............ ..... .. ......... 26 The School of Nursing ... ........................... .... ................ ... ................... ........ 31 The School of Allied Medical Professions . .. .. 3 3 The Graduate School of Arts and Sciences . .. .. .. 34 The School of Medicine . -
NCI Budget Fact Book for Fiscal Year 1991
FACT BOOK National Cancer Institute U.S. DEPARTMENT \ Public Health OF HEALTH AND \ Service HUMAN SERVICES National Institutes of Health U.S. DEPARTMENT Public Health OF HEALTH AND Service HUMAN SERVICES National Institutes of Health The information set forth in this publication is compiled and amended annually by the financial manage- ment staff of the National Cancer Institute and is intended primarily for use by members of the Institute, principal advisory groups to the In- stitute and others involved in the ad- ministration and management of the National Cancer Program . Questions regarding any of the information contained herein may be directed to the Financial Manager, National Cancer Institute, 9000 Rockville Pike, Bethesda, Maryland 20892. Page Significant Initiatives in 1991 .. .. .. .. .. .. ... .. ..... ..... ..... ..... .. ... .. .. .. , I Prevention Highlights: Meeting the Year 2000 Objectives . .. .. .. .. .. ..... .. 11 Year 2000 Goal and Objectives . .. ... .. .. .. .. .. .. ... .. ..... ..... ..... ..... .. .. .. .. ..... .. 16 Public Information Dissemination .. .. .. ... .. .. .. .. .. ..... ..... ..... ..... .. ... .. .. .. ... .. 18 Directory of Personnel ..... .. ..... ..... ..... .. ... .. .. .. .. .. .. ... .. ..... ... .. ... .. ... .. ... .. ... .. 19 National Cancer Institute Leadership: Director's Biography . ..... .. ..... ..... ..... ..... .. ... .. .. .. .. .. .. ... ..... ..... ... .. .. .. .. .. 22 President's Cancer Panel .. ..... ..... ..... .. ... .. ... .. .. .. .. .. .. ... .. ..... ... ..... . -
Department of Chemistry
Department of Chemistry Chemistry is the science of creation, discovery, and understanding at the molecular level. Its achievements continue to fuel advances in other branches of science, in medicine, and in engineering. Major new initiatives in the department include the synthesis of novel molecules to turn sunlight into chemical energy, nitrogen into ammonia, and carbon dioxide into useful reagents, the invention of new tools to investigate complex biological processes including neurochemical signaling, methods to characterize the dynamics of water and the unfolding of proteins in solution, and the design and synthesis of electronic polymers. In academic year 2004, the Chemistry Department continued its strong programs in undergraduate and graduate education. Associated with the department currently are 260 graduate students, 98 postdoctoral researchers, and 104 undergraduate chemistry majors. As of July 1, 2004, the Chemistry Department faculty comprised 31 full‐time faculty members, including 6 assistant professors, 4 associate professors, and 21 full professors, including 1 Institute Professor. Effective July 1, 2003, Professors Jianshu Cao and Andrei Tokmakoff were promoted to associate professor without tenure. In the fall, professors Catherine L. Drennan and Timothy F. Jamison were promoted to associate professor without tenure, to take effect on July 1, 2004. Major Faculty Awards and Honors • Professor Moungi Bawendi was elected to the American Academy of Arts and Sciences. • Professor Sylvia T. Ceyer was elected fellow, American Association for the Advancement of Science. • Professor Catherine L. Drennan received the Presidential Early Career Award, the Dean’s Educational and Student Advising Award, and the 2004 Edgerton Faculty Award. • Professor Gregory C. Fu received the 2004 E. -
Professor Joanne Stubbe
NESACS Member Interviews Professor Joanne Stubbe Professor Joanne Stubbe: An Interview When Joanne Stubbe, Novartis Professor of Chemistry and Biology at MIT, received a phone call late one night in September, she did not expect to hear John Holdren, President Barack Obama’s science and technology advisor, on the line. Nor did she anticipate that he was calling to inform her that she had won the National Medal of Science, the highest domestic scientiic honor. “It came as a complete surprise,” Professor Stubbe said. “I had no idea.” Professor Stubbe, together with the 8 other National Medal winners, received her award from President Obama in a ceremony on October 7, 2009. One of the best parts of receiving the award, explained Professor Stubbe, was that “my family inally igured out that what I do is important.” Nine of her family members were in Washington to witness the ceremony, characterized by Professor Stubbe as “pretty inspiring” and “very emotional.” Impact on Career Despite the importance of the award, Professor Stubbe does not anticipate that it will signiicantly impact her career. “Awards can sometimes give you visibility so you can attract better people,” said Professor Stubbe. How- ever, at a high-proile institution like MIT, such added visibility may be less important. “In the long run, is the award the key thing?” Professor Stubbe asked rhetorically. “Not really. The key thing is solving the problems.” Research Activities Professor Stubbe’s research focuses on mechanistic investigations of biochem- ical pathways involved in nucleotide metabolism. This research has led to a number of successful applications, including the mechanism-based anti- cancer drug Gemcitabine, which is patented and distributed by Eli Lilly and Company. -
Table of Contents (PDF)
January 31, 2006 ͉ vol. 103 ͉ no. 5 ͉ 1155–1656 Proceedings of the National Academy ofPNAS Sciences of the United States of America www.pnas.org Cover image: A bilaterally deaf, homozygous merle Shetland Sheepdog with ocular coloboma. Merle is an autosomal dominant coat pattern in the dog that is characterized by patches of diluted pigment intermingled with normal melanin. Sequence analysis reveals that this phenotype results from a retrotransposon insertion in the pigmentation gene SILV. In the homozygous state, this mutation results in a wide range of phenotypic anomalies. See the article by Clark et al. on pages 1376–1381. Image courtesy of Larry Wadsworth (Texas A&M University, College Station, TX). From the Cover 1376 Retrotransposon insertion in merle patterning 1209 Sustaining metal resources 1342 Tundra plant responses to warming 1394 Heart disease genes in Drosophila 1587 Brain histone deacetylase inhibitor Contents PHYSICAL SCIENCES APPLIED MATHEMATICS THIS WEEK IN PNAS 1168 Generalized multidimensional scaling: A framework for isometry-invariant partial surface matching 1155 In This Issue Alexander M. Bronstein, Michael M. Bronstein, and Ron Kimmel COMMENTARY 1633 An auxin-driven polarized transport model for phyllotaxis 1157 Teaching an old dog new tricks: SINEs of canine Henrik Jo¨nsson, Marcus G. Heisler, Bruce E. Shapiro, genomic diversity Elliot M. Meyerowitz, and Eric Mjolsness Richard Cordaux and Mark A. Batzer ➜ See companion article on page 1376 APPLIED PHYSICAL SCIENCES 1353 Multicellularity and the functional interdependence PERSPECTIVE of motility and molecular transport Cristian A. Solari, Sujoy Ganguly, John O. Kessler, Richard E. Michod, and Raymond E. Goldstein 1159 Genetic polymorphism and protein conformational plasticity in the calmodulin superfamily: Two ways CHEMISTRY to promote multifunctionality Mitsuhiko Ikura and James B. -
Synthesis of RNA with Selective Isotopic Labels for NMR Structural Studies
Synthesis of RNA with Selective Isotopic Labels for NMR Structural Studies by Thomas J. Tolbert B.S., Chemistry Purdue University, 1991 Submitted to the Department of Chemistry in Partial Fulfillment of the Requirements for the Degree of DOCTOR OF PHILOSOPHY IN BIOCHEMISTRY at the Massachusetts Institute of Technology February 1998 @ Massachusetts Institute of Technology, 1998 All Rights Reserved Signature of Author ...... ,..., .. ..... ....... ..................... SDepartment of Chemistry November 19, 1997 CCertified ertified bby......................W.... y ...................... ..... ....... I..................... ............................ James R. Williamson Associate Professor of Chemistry Thesis Supervisor Accepted by............. Dietmar Seyferth Chair, Departmental Committee on Graduate Students This doctoral thesis has been examined by a committee of the Department of Chemistry as follows: Professor JoAnne Stubbe....... ....................... ..... C hair Chair Professor James R. Williamson.............................. ............ ,-7 Thesis Supervisor Professor Lawrence J. Stern.. ........... .. .......... Synthesis of RNA with Selective Isotopic Labels for NMR Structural Studies by Thomas J. Tolbert Submitted to the Department of Chemistry on November 19, 1997 in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy in Biochemistry ABSTRACT RNA is synthesized with specific isotopic labels (2 H, 13 C, and 15N) to alleviate spectral crowding and broad linewidth problems encountered in large RNA NMR spectroscopy. A combined chemical and enzymatic synthesis is described in which glycerol (U-d8) is chemically converted into 3',4',5',5"- 2 H4-D,L-ribose, and then the 3',4',5',5"- 2 H4-D-ribose is enzymatically converted into the four NTPs of RNA. Enzymes of purine salvage and pyrimidine biosynthesis are overexpressed and purified in order to catalyze the nucleotide forming reactions. Several isotopically labeled forms of glucose are enzymatically converted into the four NTPs of RNA.