Reconstructing the Population Genetic History of the Caribbean
Reconstructing the Population Genetic History of the Caribbean Andrés Moreno-Estrada1, Simon Gravel1,2, Fouad Zakharia1, Jacob L. McCauley3, Jake K. Byrnes1,4, Christopher R. Gignoux5, Patricia A. Ortiz-Tello1, Ricardo J. Martínez3, Dale J. Hedges3, Richard W. Morris3, Celeste Eng5, Karla Sandoval1, Suehelay Acevedo-Acevedo6, Juan Carlos Martínez-Cruzado6, Paul J. Norman7, Zulay Layrisse8, Peter Parham7, Esteban González Burchard5, Michael L. Cuccaro3, Eden R. Martin3*, Carlos D. Bustamante1* 1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA 2Department of Human Genetics and Genome Quebec Innovation Centre, McGill University, Montreal, QC, Canada 3Center for Genetic Epidemiology and Statistical Genetics, John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA 4Ancestry.com DNA, LLC, San Francisco, CA, USA 5Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, CA, USA 6Department of Biology, University of Puerto Rico at Mayaguez, Puerto Rico 7Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA 8Center of Experimental Medicine "Miguel Layrisse”, IVIC, Caracas, Venezuela *Shared senior authorship and co-corresponding authors Running title: Reconstructing Human Migrations into the Caribbean Contributions: Conceived and designed experiments: ERM, MLC, JLM, AM, CDB. Performed the experiments: JLM, RJM, DJH, CE. Analyzed the data: AM, SG, FZ, JKB, CRG, PO, SA. Contributed reagents/materials/analysis tools: ERM, MLC, JLM, RWM, KS, JCM, PJN, ZL, PP, EGB, CDB. Wrote the paper: AM, SG, FZ, JKB, CRG, CDB. 1 Abstract The Caribbean basin is home to some of the most complex interactions in recent history among previously diverged human populations.
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