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COMBINED LIST OF DRUGS THAT PROLONG QT AND/OR CAUSE TORSADES DE POINTES (TDP)

CredibleMeds® has reviewed available evidence for the drugs on the following list and place them in one of three designated categories: Known Risk of TdP (KR), Possible Risk of TdP (PR) or have a Conditional Risk of TdP (CR). The full description of these categories can be found on the CredibleMeds.org website.

Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name Alfuzosin (PR) Uroxatral Ciprofloxacin (KR) Cipro and others Ezogabine (Retigabine) Potiga and others (PR) (CR) Symmetrel and others Cisapride (KR) Propulsid Famotidine (PR) Pepcid and others Amiodarone (KR) Cordarone and others Citalopram (KR) Celexa and others Felbamate (PR) Felbatol (CR) Solian and others Clarithromycin (KR) Biaxin and others Fingolimod (PR) Gilenya Elavil (Discontinued 6/13) and (PR) Anafranil (CR) others Flecainide (KR) Tambocor and others (PR) Clozaril and others Amphotericin B (CR) Fungilin and others Fluconazole (KR) Diflucan and others Cocaine (KR) Cocaine Anagrelide (KR) Agrylin and others Fluoxetine (CR) Prozac and others Crizotinib (PR) Xalkori (PR) Apokyn and others (PR) Depixol and others Tercian (PR) Abilify and others (cyamepromazine) (PR) Fluvoxamine (CR) Faverin and others Arsenic trioxide (KR) Trisenox Dabrafenib (PR) Tafinlar Foscarnet (PR) Foscavir Artenimol+piperaquine (PR) Eurartesim Dasatinib (PR) Sprycel Furosemide (frusemide) Lasix and others (CR) (PR) Saphris and others Degarelix (PR) Firmagon Galantamine (CR) Reminyl and others Astemizole (KR) Hismanal Delamanid (PR) Deltyba Garenoxacin (CR) Geninax Atazanavir (CR) Reyataz and others Desipramine (PR) Pertofrane and others Gatifloxacin (KR) Tequin Atomoxetine (PR) Strattera Dexmedetomidine (PR) Precedex and others Gemifloxacin (PR) Factive Azithromycin (KR) Zithromax and others Diphenhydramine (CR) Benadryl and others Granisetron (PR) Kytril and others Bedaquiline (PR) Sirturo Disopyramide (KR) Norpace Grepafloxacin (KR) Raxar Bendamustine (PR) Treanda and others Dofetilide (KR) Tikosyn Halofantrine (KR) Halfan Bendroflumethiazide or Dolasetron (PR) Anzemet Aprinox bendrofluazide (CR) Haldol (US & UK) and (KR) Motilium and others (KR) others Bepridil (KR) Vascor Donepezil (KR) Aricept Hydrochlorothiazide (CR) Apo-Hydro and others Bortezomib (PR) Velcade and others (CR) Sinequan and others Hydrocodone - ER (PR) Hysinglaâ„¢ ER and others Bosutinib (PR) Bosulif Dronedarone (KR) Multaq Hydroxychloroquine (CR) Plaquenil and others Buprenorphine (PR) Butrans and others (KR) Inapsine and others (CR) Atarax and others Capecitabine (PR) Xeloda Efavirenz (PR) Sustiva and others Ibogaine (KR) None Ceritinib (PR) Zykadia Eribulin mesylate (PR) Halaven Ibutilide (KR) Corvert Chloral hydrate (CR) Aquachloral and others Erythromycin (KR) E.E.S. and others (PR) Fanapt and others Chloroquine (KR) Aralen Escitalopram (KR) Cipralex and others (melipramine) (KR) Thorazine and others Tofranil Esomeprazole (CR) Nexium and others (PR) Cilostazol (KR) Pletal Indapamide (CR) Lozol and others Isradipine (PR) Dynacirc

If list is printed, check website at www.crediblemeds.org • Please see Disclaimer below • List continued over Generic Name Brand Name Generic Name Brand Name Generic Name Brand Name Itraconazole (CR) Sporanox and others Oxaliplatin (KR) Eloxatin Solifenacin (CR) Vesicare

Ivabradine (CR) Procoralan and others Oxytocin (PR) Pitocin and others Sorafenib (PR) Nexavar

Ketanserin (PR) Sufrexal (PR) Invega and others Sotalol (KR) Betapace and others

Ketoconazole (CR) Nizoral and others Panobinostat (PR) Farydak Sparfloxacin (KR) Zagam

Lansoprazole (CR) Prevacid (CR) Protonix and others (KR) Dogmatil and others

Lapatinib (PR) Tykerb and others Papaverine HCl (Intra-coronary) (KR) Barnetil and others none (KR) Lenvatinib (PR) Lenvima Sunitinib (PR) Sutent Paroxetine (CR) Paxil and others Leuprolide (PR) Lupron and others Tacrolimus (PR) Prograf and others Pasireotide (PR) Signifor Levofloxacin (KR) Levaquin and others Nolvadex(discontinued 6/13) and Tamoxifen (PR) Pazopanib (PR) Votrient others (KR) Nosinan and others Pentamidine (KR) Pentam Telaprevir (CR) Incivo and others Levomethadyl acetate (KR) Orlaam Perflutren lipid microspheres (PR) Definity Telavancin (PR) Vibativ Levosulpiride (KR) Lesuride and others (PR) Trilafon and others Telithromycin (PR) Ketek Lithium (PR) Eskalith and others Pilsicainide (PR) Sunrythm Terfenadine (KR) Seldane Imodium and many other OTC Loperamide (CR) and Rx brands (KR) Orap Terlipressin (KR) Teripress and others

Melperone (PR) Bunil and others (PR) Dipiperon (E.U) and others Terodiline (KR) Micturin and others

Mesoridazine (KR) Serentil Posaconazole (CR) Noxafil and others (PR) Nitoman and others

Methadone (KR) Dolophine and others Probucol (KR) Lorelco (KR) Mellaril and others

Metoclopramide (CR) Reglan and others Procainamide (KR) Pronestyl and others (PR) Tiapridal and others

Metronidazole (CR) Flagyl and many others (PR) Phenergan Tizanidine (PR) Zanaflex and others

Mifepristone (PR) Korlym and others Propofol (KR) Diprivan and others Tolterodine (PR) Detrol and others

Mirabegron (PR) Myrbetriq (PR) Dominal and others Torasemide (CR) Demadex and others

Mirtazapine (PR) Remeron (CR) Seroquel Toremifene (PR) Fareston

Moexipril/HCTZ (PR) Uniretic and others Quinidine (KR) Quinaglute and others Desyrel (discontinued 6/13) and Trazodone (CR) others Moxifloxacin (KR) Avelox and others Quinine sulfate (CR) Qualaquin (PR) Surmontil and others Nelfinavir (CR) Viracept Ranolazine (CR) Ranexa and others Tropisetron (PR) Navoban and others Nicardipine (PR) Cardene Rilpivirine (PR) Edurant and others Vandetanib (KR) Caprelsa Nilotinib (PR) Tasigna (PR) Risperdal Vardenafil (PR) Levitra Norfloxacin (PR) Noroxin and others Ritonavir (CR) Norvir Vemurafenib (PR) Zelboraf Nortriptyline (PR) Pamelor and others Romidepsin (PR) Istodax Venlafaxine (PR) Effexor and others Ofloxacin (PR) Floxin Roxithromycin (KR) Rulide and others Voriconazole (CR) VFend (CR) Zyprexa and others Saquinavir (PR) Invirase(combo) Vorinostat (PR) Zolinza Omeprazole (CR) Losec and others (PR) Serdolect and others (CR) Geodon and others Ondansetron (KR) Zofran and others Sertraline (CR) Zoloft and others (PR) Losizopilon and others Osimertinib (PR) Tagrisso Sevoflurane (KR) Ulane and others

Note: Medicines on this list are reviewed on an ongoing basis to assure that the available evidence supports their continued placement on this list. Because, the list changes regularly, we recommend always checking the website at crediblemeds.org for the most up-to-date information. Most drugs have multiple brand names and it is not practical to list them on this form. The CredibleMeds.org website provides a partial list of the more common brands.

Disclaimer and Waiver: The information presented here is intended solely for the purpose of providing general information about health-related matters. It is not intended for any other purpose, including but not limited to medical advice and/or treatment, nor is it intended to substitute for the users’ relationships with their own health care providers. To that extent, by use of this list and the information it contains, the user affirms the understanding of the purpose and releases AZCERT, Inc. from any claims arising out of his/her use of this list. The Terms of Use Agreement for this list and the CredibleMeds website is available at https://www.crediblemeds.org/terms. The absence of drugs from these lists should not be considered an indication that they are free of risk of QT prolongation or torsades de pointes. Few medicines have been tested for this risk in patients, especially those with congenital long QT syndrome. This list and the CredibleMeds® website are intended for personal and professional use only and are protected by U.S. Copyright (title 17, U.S. Code). Unauthorized commercial use is prohibited. Generated: April 25, 2017. List last revised: March 14, 2017