Antipsychotics | V1 | 08/20

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BMF 84 - Antipsychotics | v1 | 08/20

Antipsychotics

Antipsychotic medications (neuroleptics) are used for the treatment of psychosis, mainly schizophrenia and manic depression (bipolar disorder). They reduce symptoms such as hallucinations, delusions, and paranoia, and can also be used to help severe anxiety or depression. Antipsychotic medications have been available for the treatment of psychosis for over half a century. The first being chlorpromazine (Thorazine), introduced in the early 1950’s. The list now extends to over 20 different compounds. Antipsychotics act by blocking dopamine receptors Pimozide, Trifluoperazine, and Sulpiride. Atypical include; in the brain and interfering with dopaminergic Amisulpride, Aripiprazole, Clozapine, Olanzapine, transmission. Side effects include movement disorders Quetiapine and Risperidone. Atypical antipsychotics, are similar to Parkinson’s disease, such as shaking/tremor, useful in patients that do not respond to treatment with involuntary body movements and inner restlessness. typical antipsychotics. They cause less extrapyramidal These are referred to as extrapyramidal symptoms, side effects and have a greater efficacy to treat negative and can be controlled with anticholinergic drugs such symptoms. Atypical antipsychotics also block dopamine, as orphenadrine and procyclidine. Other side effects but to a lesser degree than the older drugs. They also include lethargy, weight gain and sexual dysfunction. work on serotonin. Longer term there is increased risk of developing type Some antipsychotics are available in depot form, 2 diabetes, high blood pressure, heart problems and i.e. Haloperidol decanoate, Flupenthixol decanoate, osteoporosis. Fluphenazine decanoate, Pipothiazine palmitate and Antipsychotics are may be classified as typical or atypical, Zuclopenthixol decanoate. These are injected into muscle or first and second generation respectively. Typical every 2 to 4 weeks and release slowly over time. This antipsychotics include; Chlorpromazine, Haloperidol, prevents patients forgetting to take their medication. Antipsychotics product listing

Phenoxy derivatives:

Chiron No. Structure Name CAS Amisulpride

10349.17 (±)‐Amisulpride 71675‐85‐9

Aripiprazole

2305.23 Aripiprazole 129722‐12‐9

9653.23 Aripiprazole‐d8 (butyl‐d8) 1089115‐04‐7

11004.23 Dehydroaripiprazole hydrochloride 1008531‐60‐9

Chlorpromazine

10350.17 HCl Chlorpromazine hydrochloride 69‐09‐0 N Cl

S D D D

D N D O 10841.17 D HO Chlorpromazine‐d6 oxalate (N,N‐dimethyl‐d6) 1208197‐23‐9 OH N Cl O

S Clozapine

9275.18 Clozapine 5786‐21‐0

9406.18 Clozapine‐d4 (4‐ methylpiperazinyl‐ 2, 2, 6, 6‐ d4) 204395‐52‐8

10807.17 Norclozapine (N‐Desmethyl Clozapine) 6104‐71‐8

10808.18 Clozapine N‐oxide (4-Oxido-piprazinyl) 34233‐69‐7

Droperidol Phenoxy derivatives:

Chiron No. Structure Name CAS Amisulpride

10349.17 (±)‐Amisulpride 71675‐85‐9

Aripiprazole

2305.23 Aripiprazole 129722‐12‐9

9653.23 Aripiprazole‐d8 (butyl‐d8) 1089115‐04‐7

11004.23 Dehydroaripiprazole hydrochloride 1008531‐60‐9

Chlorpromazine

10350.17 Chlorpromazine hydrochloride 69‐09‐0

10841.17 Chlorpromazine‐d6 oxalate (N,N‐dimethyl‐d6) 1208197‐23‐9

Clozapine

9275.18 Clozapine 5786‐21‐0

9406.18 Clozapine‐d4 (4‐ methylpiperazinyl‐ 2, 2, 6, 6‐ d4) 204395‐52‐8

10807.17 Norclozapine (N‐Desmethyl Clozapine) 6104‐71‐8

10808.18 Clozapine N‐oxide (4-Oxido-piprazinyl) 34233‐69‐7 Phenoxy derivatives:

Chiron No. Structure Name CAS AmisulprideDroperidol

10349.17 (±)‐Amisulpride 71675‐85‐9 11983.22 Droperidol 548‐73‐2 Aripiprazole

2305.23 AripiprazoleFluspirilene 129722‐12‐9

9748.29 Fluspirilene 1841‐19‐6

9653.23 Aripiprazole‐d8 (butyl‐d8) 1089115‐04‐7

Flupentixol S

F F 11004.2310358.23 F FlupentixolDehydroaripiprazole dihydrochloride hydrochloride (cis+trans) 10085312413‐38‐60‐9‐9

N 2 HCl N HO Chlorpromazine

10350.17 Chlorpromazine hydrochloride 69‐09‐0 10712.23 cis‐(Z)‐Flupentixol dihydrochloride 51529‐01‐2

Fluphenazine 10841.17 Chlorpromazine‐d6 oxalate (N,N‐dimethyl‐d6) 1208197‐23‐9

11163.22 Fluphenazine dihydrochloride 146‐56‐5 Clozapine

9275.18 HaloperidolClozapine 5786‐21‐0

10345.21 Haloperidol 52‐86‐8

9406.18 Clozapine‐d4 (4‐ methylpiperazinyl‐ 2, 2, 6, 6‐ d4) 204395‐52‐8

10359.21 Haloperidol‐d4 (4‐chlorophenyl‐d4) 1189986‐59‐1

10807.17 Norclozapine (N‐Desmethyl Clozapine) 6104‐71‐8 Levomepromazine

11807.23 Levomepromazine maleate 7104‐38‐3

10808.18 Clozapine N‐oxide (4-Oxido-piprazinyl) 34233‐69‐7

Levosulpiride

12740.15 LevosulpirideDroperidol ((S)‐(‐)‐Sulpiride) 23672‐07‐3

Olanzapine 11983.22 Droperidol 548‐73‐2

Fluspirilene

9748.29 Fluspirilene 1841‐19‐6

Flupentixol

10358.23 Flupentixol dihydrochloride (cis+trans) 2413‐38‐9

10712.23 cis‐(Z)‐Flupentixol dihydrochloride 51529‐01‐2

Fluphenazine

11163.22 Fluphenazine dihydrochloride 146‐56‐5

Haloperidol

10345.21 Haloperidol 52‐86‐8

10359.21 Haloperidol‐d4 (4‐chlorophenyl‐d4) 1189986‐59‐1

Levomepromazine

11807.23 Levomepromazine maleate 7104‐38‐3

Levosulpiride

12740.15 LevosulpiridePhenoxy derivatives: ((S)‐(‐)‐Sulpiride) 23672‐07‐3

Chiron No. Structure Name CAS AmisulprideOlanzapine

10349.17 (±)‐Amisulpride 71675‐85‐9 3761.17 Olanzapine 132539‐06‐1

Aripiprazole

D D 2305.23 D Aripiprazole 129722‐12‐9 N

9766.17 N Olanzapine‐d3 (4‐methyl‐d3) 786686‐79‐1 N

N S 9653.23 H Aripiprazole‐d8 (butyl‐d8) 1089115‐04‐7 NH

N 11913.16 N N‐Demethylolanzapine 161696‐76‐0

N S 11004.23 H Dehydroaripiprazole hydrochloride 1008531‐60‐9

N Chlorpromazine N 3924.23 Olanzapine 10‐N‐β‐D‐glucuronide 186792‐80‐3 N S 10350.17 OH Chlorpromazine hydrochloride 69‐09‐0 O O OH OH OH Perphenazine HO N N 10841.17 Chlorpromazine‐d6 oxalate (N,N‐dimethyl‐d6) 1208197‐23‐9 9749.21 Perphenazine 58‐39‐9 N Cl

S Clozapine HO N N 9275.18 Clozapine 5786‐21‐0 9914.21 D D Perphenazine‐d4 (phenothiazine‐ 1, 3, 7, 9‐ d4) 155593‐75‐2 N Cl

D S D Phenothiazine H N 13859.129406.18 Clozapine‐d4 (4‐ Phenothiazinemethylpiperazinyl ‐ 2, 2, 6, 6‐ d4) 20439592‐84‐52‐2‐8 S Pimozide

10807.17 Norclozapine (N‐Desmethyl Clozapine) 6104‐71‐8

14255.28 Pimozide 2062‐78‐4 N F

N O 10808.18 N Clozapine N‐oxide (4-Oxido-piprazinyl) 34233‐69‐7 H Pipamperone

N Droperidol NH2 15312.21 O Pipamperone 1893‐33‐0 N O

F Prochloroperazine 3761.17 Olanzapine 132539‐06‐1

9766.17 Olanzapine‐d3 (4‐methyl‐d3) 786686‐79‐1

11913.16 N‐Demethylolanzapine 161696‐76‐0

3924.23 Olanzapine 10‐N‐β‐D‐glucuronide 186792‐80‐3

Perphenazine

9749.21 Perphenazine 58‐39‐9

9914.21 Perphenazine‐d4 (phenothiazine‐ 1, 3, 7, 9‐ d4) 155593‐75‐2

Phenothiazine

13859.12 Phenothiazine 92‐84‐2

Pimozide

14255.28 Pimozide 2062‐78‐4

Pipamperone

15312.21 Pipamperone 1893‐33‐0 Phenoxy derivatives:

Chiron No. Structure Name CAS ProchloroperazineAmisulpride N HO O O N 2 10349.17 (±)‐Amisulpride 71675‐85‐9 OH 10856.2 Prochloroperazine maleate 84‐02‐6 N Cl Aripiprazole S Promazine 2305.23 Aripiprazole 129722‐12‐9 N

11164.17 HCl Promazine hydrochloride 53‐60‐1 N

9653.23 S Aripiprazole‐d8 (butyl‐d8) 1089115‐04‐7

N OH 11989.2 N 2‐(1‐Hydroxypropyl)promazine 110080‐35‐8

S 11004.23 DehydroaripiprazoleQuetiapine hydrochloride 1008531‐60‐9 OH O

N O Chlorpromazine 10835.46 0.5 HO Quetiapine hemifumarate 111974‐72‐2 N OH N O 10350.17 Chlorpromazine hydrochloride 69‐09‐0 S

OH O D D N D D O 13187.46 D D 0.5 HO Quetiapine‐d8 hemifumarate 1435938‐24‐1 N OH D 10841.17 N D O Chlorpromazine‐d6 oxalate (N,N‐dimethyl‐d6) 1208197‐23‐9

S Risperidone Clozapine N O

O 10337.23 F Risperidone 106266‐06‐2 N 9275.18 N Clozapine 5786‐21‐0 N OH N

N 10338.23 N (9RS)‐9‐Hydroxyrisperidone (Paliperidone) 144598‐75‐4 F O 9406.18 Clozapine‐d4 (4‐ methylpiperazinyl‐ 2, 2, 6, 6‐ d4) 204395‐52‐8 O N Thioridazine

11419.21 HCl Thioridazine hydrochloride 130‐61‐0 10807.17 Norclozapine (N‐Desmethyl Clozapine) 6104‐71‐8 N S

S Trifluoperazine N N 10808.18 HCl Clozapine N‐oxide (4-Oxido-piprazinyl) 34233‐69‐7 11192.21 F Trifluoperazine dihydrochloride 440‐17‐5 F N F

S Droperidol Triflupromazine

N HCl

11195.18 F Triflupromazine hydrochloride 1098‐60‐8 F N F

S Ziprasidone 10856.2 Prochloroperazine maleate 84‐02‐6

10856.2 Prochloroperazine maleate 84‐02‐6

Promazine

11164.17 Promazine hydrochloride 53‐60‐1

11989.2 2‐(1‐Hydroxypropyl)promazine 110080‐35‐8

11989.2 2‐(1‐Hydroxypropyl)promazine 110080‐35‐8 Quetiapine

Quetiapine

10835.46 Quetiapine hemifumarate 111974‐72‐2

13187.46 Quetiapine‐d8 hemifumarate 1435938‐24‐1

Risperidone

Risperidone 10337.23 Risperidone 106266‐06‐2

10337.23 Risperidone 106266‐06‐2

10338.23 (9RS)‐9‐Hydroxyrisperidone (Paliperidone) 144598‐75‐4

Thioridazine

11419.21 Thioridazine hydrochloride 130‐61‐0

Trifluoperazine

11192.21 Trifluoperazine dihydrochloride 440‐17‐5

Triflupromazine

11195.18 Triflupromazine hydrochloride 1098‐60‐8 Phenoxy derivatives: 11195.18 Triflupromazine hydrochloride 1098‐60‐8 Chiron No. Structure Name CAS AmisulprideZiprasidone S N Ziprasidone 10349.17 (±)‐Amisulpride 71675‐85‐9 N 11901.21 HCl Ziprasidone hydrochloride monohydrate 138982‐67‐9 N H O 11901.21 2 Ziprasidone hydrochlorideAripiprazole monohydrate 138982‐67‐9

Cl 2305.23 Aripiprazole 129722‐12‐9 HN Zuclopenthixol O Zuclopenthixol HO N 10284.22 N Zuclopenthixol (cis+trans) 982‐24‐1 9653.23 Aripiprazole‐d8 (butyl‐d8) 1089115‐04‐7 10284.22 Zuclopenthixol (cis+trans) 982‐24‐1 Cl

S S 11004.2310285.24 DehydroaripiprazoleZuclopenthixol acetate hydrochloride (cis+trans) 100853185721‐‐0560‐‐79 Cl 10285.24 Zuclopenthixol acetate (cis+trans) 85721‐05‐7

N O Chlorpromazine N O S 10350.1714033.22 cis‐Chlorpromazine(Z)‐Zuclopenthixol hydrochloride dihydrochloride 69633‐09‐59‐0‐0 Cl 2 HCl 14033.22 cis‐(Z)‐Zuclopenthixol dihydrochloride 633‐59‐0

N N OH

HO N 10841.17 O Chlorpromazine‐d6 oxalate (N,N‐dimethyl‐d6) 1208197‐23‐9 10713.26 N OH cis‐(Z)‐Zuclopenthixol succinate 53772‐83‐1 (free base) HO 10713.26 O cis‐(Z)‐Zuclopenthixol succinate 53772‐83‐1 (free base) Cl Clozapine S

D D HO 10383.22 N O cis‐(Z)‐Zuclopenthixol‐d4 succinate 1246833‐97‐5 9275.18 D D N OH Clozapine 5786‐21‐0 HO 10383.22 O cis‐(Z)‐Zuclopenthixol‐d4 succinate 1246833‐97‐5

9406.18 Antipsychotic mixes Clozapine‐d4 (4‐ methylpiperazinyl‐ 2, 2, 6, 6‐ d4) 204395‐52‐8 AntipsychoticAntipsychotic mixes mixes Chiron No. Name CAS Concentration S‐4965‐100‐ME Antipsychotic Mix 1 : 12 components in 1 mL methanol Chiron10349.17 No. AmisulprideName 71675CAS‐85‐9 Concentration S‐496510807.1710793.21‐100‐ME Biperiden hydrochloride (mixture of diastereomersAntipsychotic) Mix 1Norclozapine : 12 components (N1235‐Desmethyl in‐82 1‐ mL1 methanol Clozapine) 6104‐71‐8 10349.1710350.17 ChlorpromazineAmisulpride hydrochloride 7167569‐09‐85‐0‐9 10793.219275.18 Biperiden hydrochlorideClozapine (mixture of diastereomers) 12355786‐2182‐01 10350.1710345.21 ChlorpromazineHaloperidol hydrochloride 5269‐8609‐80 10338.239275.18 9‐HydroxyrisperidoneClozapine 1445985786‐21‐75‐0‐4 100 μg/mL each 10345.2111913.16 N‐DemethylolanzapineHaloperidol 16169652‐86‐76‐8 ‐0 10338.23 9‐Hydroxyrisperidone 144598‐75‐4 (as free base) 10807.17 Norclozapine 6104‐71‐8 100 μg/mL each N‐Demethylolanzapine 10808.1811913.163761.17 Olanzapine Clozapine N‐oxide161696132539 (4-Oxido-piprazinyl‐0676‐10 ) (as34233 free‐69 base)‐7 10807.1710835.46 QuetiapineNorclozapine hemifumarate 1119746104‐71‐72‐8‐2 10337.233761.17 RisperidoneOlanzapine 132539106266‐06‐21 10835.4611419.21 ThioridazineQuetiapine hemifumarate hydrochloride 111974130‐61‐72‐0‐2 10337.23 Risperidone 106266‐06‐2 Droperidol S‐493211419.21‐25μM‐ME Thioridazine hydrochlorideAntipsychotic & Antidepressant Mix 1 : 7 components130‐61‐0 in 1 mL methanol 10345.21 Haloperidol 52‐86‐8 S‐49323761.17‐25μM‐ME Olanzapine Antipsychotic & Antidepressant Mix 1 : 7132539 components‐06‐1 in 1 mL methanol 10345.2111913.16 N‐DesmethylolanzapineHaloperidol 16169652‐86‐76‐8 ‐0 10337.233761.17 RisperidoneOlanzapine 132539106266‐06‐21 25μM 11913.1610338.23 N9‐Desmethylolanzapine‐Hydroxyrisperidone 161696144598‐7576‐40 (as free base) 10337.239288.17 RisperidoneMirtazapine 10626685650‐52‐06‐8‐2 25μM 10338.2311189.16 Desmethylmirtazapine9‐Hydroxyrisperidone hydrochloride 61337144598‐68‐6 (free‐75‐4 base) (as free base)

S‐4983‐ASS‐ME Antipsychotic & Antidepressant Mix 2 : 6 components in 1 mL methanol 11163.22 Fluphenazine dihydrochloride 146‐56‐510 µmol/L (4.38 µg/mL) 10712.23 cis‐(Z)‐Flupentixol dihydrochloride 51529‐01‐210 µmol/L (4.35 µg/mL) 9749.21 Perphenazine 58‐39‐910 µmol/L (4.04 µg/mL) 10284.22 Zuclopenthixol (cis+trans) 982‐24‐120 µmol/L (8.02 µg/mL) 9284.17 (+)‐(1S,4S)‐Sertraline hydrochloride 79559‐97‐0 100 µmol/L (30.62 µg/mL) 12000.16 rac‐Norsertraline hydrochloride 91797‐57‐8 100 µmol/L (29.22 µg/mL) (as free base) S‐5204‐25μM‐ME Antipsychotic & Antidepressant Mix 3 : 8 components in 1 mL methanol 10345.21 Haloperidol 52‐86‐8 3761.17 Olanzapine 132539‐06‐1 11913.16 N‐Desmethylolanzapine 161696‐76‐0 10337.23 Risperidone 106266‐06‐2 25μM 10338.23 (9RS)‐9‐Hydroxyrisperidone 144598‐75‐4 (as free base) 9288.17 Mirtazapine 85650‐52‐8 12043.16 Desmethylmirtazapine dihydrochloride 61337‐68‐6 (freebase) 11811.18 Vortioxetine hydrochloride 960203‐28‐5

Accuracy controls

These accuracy controls were originally prepared as proficiency testing material for the GTFCh by ARVECON GmbH. Target values are batch specific and the consensus values obtained from the trial. No restrictions were placed on sample preparation and analytical methodology. Quantitative analyses were performed by the participants using HPLC and LC/MS(/MS). The target values are released by the coordinator of the proficiency testing of the GTFCh.

ACQ‐TDMC TDM ‐ Neuroleptics in serum 6 x 4 ml Serum (freeze dried) Aripiprazole Flupentixol (cis) Fluphenazine Haloperidol Sertindol Sulpiride Zotepine

ACQ‐TDMA TDM ‐ Neuroleptics in serum 6 x 3 ml Serum (freeze dried) Clozapine Desmethylclozapine Olanzapine Quetiapine Amisulpride Perazine Risperidone 9‐OH‐Risperidone Ziprasidone Citalopram

Please enquire for availability and current batch target values. 11901.21 Ziprasidone hydrochloride monohydrate 138982‐67‐9

Zuclopenthixol

10284.22 Zuclopenthixol (cis+trans) 982‐24‐1

10285.24 Zuclopenthixol acetate (cis+trans) 85721‐05‐7

14033.22 cis‐(Z)‐Zuclopenthixol dihydrochloride 633‐59‐0

10713.26 cis‐(Z)‐Zuclopenthixol succinate 53772‐83‐1 (free base)

10383.22 cis‐(Z)‐Zuclopenthixol‐d4 succinate 1246833‐97‐5

9288.17 Mirtazapine 85650‐52‐8 11189.16 AntipsychoticDesmethylmirtazapine hydrochloride mixes 61337‐68‐6 (free base) 9288.17 Mirtazapine 85650‐52‐8 S‐498311189.16‐ASS‐ME Desmethylmirtazapine hydrochlorideAntipsychotic & Antidepressant Mix61337 2 : 6 components‐68‐6 (free base) in 1 mL methanol Chiron11163.22 No. FluphenazineName dihydrochloride 146CAS‐56‐510 µmol/LConcentration (4.38 µg/mL) S‐4965498310712.23‐100ASS‐ME cis‐(Z)‐Flupentixol dihydrochlorideAntipsychoticAntipsychotic & Antidepressant Mix 1 : 12 Mix components 2 : 6 components51529 in‐01 1 mL‐21 methanolin 1 mL methanol 0 µmol/L (4.35 µg/mL) 10349.1711163.229749.21 FluphenazinePerphenazineAmisulpride dihydrochloride 7167514658‐‐3956‐85‐‐9151‐9 0 µmol/L (4.04(4.38 µg/mL) 10793.2110712.2310284.22 Biperidencis hydrochloride‐(Z)Zuclopenthixol‐Flupentixol (mixture dihydrochloride (cis+trans) of diastereomers) 515291235982‐‐24‐8201‐‐12‐1210 µmol/L (8.02(4.35 µg/mL) 10350.179749.219284.17 (+)Chlorpromazine‐(1S,4S)‐PerphenazineSertraline hydrochloride hydrochloride 795596958‐0939‐97‐091‐0 1000 µmol/L (30.62(4.04 µg/mL) µg/mL) 10284.229275.1812000.16 racZuclopenthixol‐NorsertralineClozapine hydrochloride(cis+trans) 917975786982‐‐2421‐57‐‐120‐8 1000 µmol/L (29.22(8.02 µg/mL) µg/mL) 10345.219284.17 (+)‐(1S,4S)‐SertralineHaloperidol hydrochloride 7955952‐86‐97‐8‐0 100 µmol/L(as free (30.62 base) µg/mL) S‐520410338.2312000.16‐25μM‐ME rac‐Norsertraline9‐Hydroxyrisperidone hydrochlorideAntipsychotic & Antidepressant Mix 3 : 8 144598components91797‐‐5775‐‐84 in 1 mL methanol 100 µmol/L (29.22 µg/mL) 100 μg/mL each N‐DemethylolanzapineHaloperidol (as free base) 11913.1610345.21 16169652‐86‐76‐8‐0 (as free base) S‐520410807.173761.17‐25μM‐ME NorclozapineOlanzapineAntipsychotic & Antidepressant Mix 3 : 8 components1325396104‐71‐06‐8‐1 in 1 mL methanol 10345.213761.1711913.16 N‐DesmethylolanzapineHaloperidolOlanzapine 13253916169652‐86‐‐06‐768 ‐‐10 10835.463761.1710337.23 QuetiapineOlanzapineRisperidone hemifumarate 111974132539106266‐‐7206‐‐21 25μM 11913.16 N‐Desmethylolanzapine 161696‐76‐0 10337.2310338.23 (9RS)‐9‐RisperidoneHydroxyrisperidone 106266144598‐‐0675‐‐24 (as free base) 10337.23 Risperidone 106266‐06‐2 11419.219288.17 ThioridazineMirtazapine hydrochloride 85650130‐61‐52‐0‐8 25μM 10338.2312043.16 Desmethylmirtazapine(9RS)‐9‐Hydroxyrisperidone dihydrochloride 61337144598‐68‐6 (freebase)‐75‐4 (as free base) S‐49329288.1711811.18‐25μM‐ME VortioxetineMirtazapine hydrochlorideAntipsychotic & Antidepressant Mix 1 : 796020385650 components‐52‐28‐8‐5 in 1 mL methanol 10345.2112043.16 DesmethylmirtazapineHaloperidol dihydrochloride 61337‐6852‐‐686 (freebase)‐8 11811.183761.17 VortioxetineOlanzapine hydrochloride 960203132539‐0628‐15 11913.16 N‐Desmethylolanzapine 161696‐76‐0 10337.23 Risperidone 106266‐06‐2 25μM Accuracy10338.23 controls9‐Hydroxyrisperidone 144598‐75‐4 (as free base) Accuracy controls These accuracy controls were originally prepared as proficiency testing material for the GTFCh by ARVECON GmbH. Target Thesevalues accuracy are batch controls specific were originallyAccuracy and the prepared consensus controlsas proficiency values obtained testing material from forthe th trial.e GTFCh No by restrictions ARVECON GmbH. were Target placed values on aresample batch specificpreparation and the consensusand analytical values methodology.obtained from the Quantitative trial. No restrictions analyses were were placed performed on sample preparation by the participants and analytical using methodology. HPLC and Quantitative LC/MS(/MS). analyses The were target Theseperformedvalues accuracy are by released the controls participants bywere the originally using coordinator HPLC prepared and LC/MS(/MS). of as the proficiency proficiency The testingtarget testingvalues material are of for released the the GTFChGTFCh. by the by coordinatorARVECON GmbH. of the Targetproficiency values testing are batch of the specific GTFCh. and the consensus values obtained from the trial. No restrictions were placed on sample preparation and analytical methodology. Quantitative analyses were performedACQ ‐byTDMC the participants usingTDM HPLC ‐ Neuroleptics and LC/MS(/MS). in serum The target values are released by the coordinator6 x 4 ml of the proficiency testingSerum of the (freezeGTFCh. dried) Aripiprazole ACQ‐TDMC TDM ‐ NeurolepticsFlupentixol (cis) in serum 6 x 4 ml Serum (freeze dried) FluphenazineAripiprazole FlupentixolHaloperidol (cis) FluphenazineSertindol HaloperidolSulpiride SertindolZotepine Sulpiride ACQ‐TDMA TDM ‐ NeurolepticsZotepine in serum 6 x 3 ml Serum (freeze dried) Clozapine ACQ‐TDMA TDMDesmethylclozapine ‐ Neuroleptics in serum 6 x 3 ml Serum (freeze dried) OlanzapineClozapine DesmethylclozapineQuetiapine OlanzapineAmisulpride QuetiapinePerazine AmisulprideRisperidone 9‐OHPerazine‐Risperidone RisperidoneZiprasidone 9‐OHCitalopram‐Risperidone Ziprasidone Please enquirePlease for availability enquire for availability and Citalopramcurrent and currentbatch batchtarget target values. values.

Please enquire for availability and current batch target values. For ordering and information about prices and delivery in your country, please contact your local distributor:

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