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2019 Recruiter Contact Information SCHEDULE OF EVENTS SATURDAY, NOVEMBER 9, 2019 8:00 AM ARRIVAL AND POSTER SETUP Vande Woude Sessions Conference Room and Cook-Hauenstein Hall 8:15 AM RECRUITER ARRIVAL AND SETUP DeVos Lobby 9:00 AM WELCOME Tomatis Auditorium Steve Triezenberg, PhD Dean, Van Andel Institute Graduate School and WMRUGS Master of Ceremonies 9:15 AM KEYNOTE SPEAKER ADDRESS Tomatis Auditorium Paloma Vargas, PhD Assistant Professor of Biology and Director, Hispanic-Serving Institute Initiatives California Lutheran University “Learning Through Research: Life Lessons from a Latinx Biologist” 10:00 AM POSTER SESSION I Vande Woude Sessions Conference Room and Cook-Hauenstein Hall Presenters at even-numbered posters 11:25 AM GRADUATE STUDENT RESEARCH TALK Tomatis Auditorium Zach DeBruine, PhD Candidate – Van Andel Institute Graduate School “Frizzled GPCRs initiate and amplify signaling through independent mechanisms” 11:40 AM UNDERGRADUATE STUDENT RESEARCH TALKS Tomatis Auditorium Svetlana Djirackor, Aquinas College “Subcloning of zebrafish NOD1 alleles into UAS:P2A-nls-EGFP for investigation of NOD1’s role in hematopoietic stem cell development” Liam Ferraby, Calvin University “The Science of Providing Services Spatially for Returning Citizens” 12:10 PM LUNCH Cook-Hauenstein Hall Lunch seating is available in the café, conference rooms 3104 & 3105, the pre-function area outside of conference rooms 3104 & 3105 and Tomatis Auditorium 12:35 PM RECORDED TED TALKS Tomatis Auditorium Please join us in the auditorium to watch recorded TED Talks 1:10 PM POSTER SESSION II Vande Woude Sessions Conference Room and Cook-Hauenstein Hall Presenters at odd-numbered posters 2:35 PM UNDERGRADUATE STUDENT RESEARCH TALKS Tomatis Auditorium Katelyn Brown, Ferris State University – College of Pharmacy “Metabolic Engineering for Production of Novel Tetracenomycins” Erin Reasoner, Grand Valley State University “Dopamine D2 receptor activation regulates aversive effects of methamphetamine” Alicia Bostwick, Hope College “Investigating Mechanisms of Regulation of Mitochondrial DNA Transcription” Mya Gough, Kalamazoo College “Design and Synthesis of Maleimide-Tryptamine Hybrids as Potential Antibacterial Agents” 3:35 PM CONCLUSION Graduate School, medical school, professional master’s program and internship/employment recruiters/representatives are located in the DeVos Lobby. Start and end times for recruiters/representatives will vary. A list of recruiters/representatives, their contact information, and their availability is provided on pages 33-39. Page 1 of 39 WEST MICHIGAN REGIONAL UNDERGRADUATE SCIENCE RESEARCH CONFERENCE ACKNOWLEDGEMENTS Costs for the 2019 West Michigan Regional Undergraduate Science Research Conference are underwritten by our title sponsor Gentex Corporation, memorial sponsor Generous Gifts Honoring Dr. Gordon Van Harn, poster session sponsors Ferris State University’s College of Pharmacy and Grand Valley State University, supporting sponsor Western Michigan University’s The Graduate College, as well as by the following organizing institutions: Aquinas College, Calvin University, Ferris State University – College of Pharmacy, Grand Valley State University, Hope College, Kalamazoo College, and Van Andel Institute Graduate School. TITLE SPONSOR MEMORIAL SPONSOR POSTER SESSION SPONSOR POSTER SESSION SPONSOR SUPPORTING SPONSORS Page 2 of 39 ADDITIONAL ACKNOWLEDGEMENTS – COMMITTEE AND SUPPORT STAFF WMRUGS ORGANIZING INSTITUTIONS AND ORGANIZING COMMITTEE Elizabeth Jensen, PhD – Aquinas College Keith Grasman, PhD – Calvin University Eric Nybo, PhD – Ferris State University, College of Pharmacy Mark Staves, PhD – Grand Valley State University Kristin Dittenhafer-Reed, PhD – Hope College Dwight Williams, PhD – Kalamazoo College Mary Winn, PhD – Van Andel Institute Graduate School / Van Andel Research Institute WMRUGS HOST Thank you to Van Andel Institute for hosting the West Michigan Regional Undergraduate Science Research Conference for 13 years! WMRUGS SUPPORT STAFF Cover images designed by Frank Brenner, VAI Communications & Marketing Associate Social media administration and support provided by Alex Edema and Zane McMillin, Associates – VAI Communications & Marketing, Caitlin Smith, Senior Administrative Assistant – Communications & Marketing and Kayla Habermehl, Science Communications Specialist – Office of the Chief Scientific Officer Administrative support provided by Michelle Love, Van Andel Institute Graduate School staff, the graduate students of Van Andel Institute Graduate School and the post-doctoral fellows from Van Andel Research Institute Audiovisual services provided by Terry Ballard and Bill Baillod with Van Andel Institute Production Services, and Tim Sundt with Viking Creative, LLC Catering services provided by Eurest Dining Services Page 3 of 39 Page 4 of 39 KEYNOTE SPEAKER 9:15 AM | Tomatis Auditorium Paloma Vargas, PhD Assistant Professor of Biology and Director, Hispanic-Serving Institute Initiatives California Lutheran University “Learning Through Research: Life Lessons from a Latinx Biologist” For more information on Dr. Vargas, visit: https://www.callutheran.edu/faculty/profile.html?id=palomav In this Keynote Address, Dr. Paloma Vargas, will discuss the roles of mentoring and research on the success of students from underserved backgrounds. Dr. Vargas will provide anecdotes from her own lived experiences on the impact of mentoring, being a mentored, and working in research have had on her own career trajectory & how this has influenced her work in diversity and inclusion in higher education. Dr. Vargas will also share high- impact practices to promote student success. Dr. Vargas is an Assistant Professor in Biology and the serves as the Director of Hispanic-Serving Institute Initiatives at California Lutheran University in Thousand Oaks, CA. Page 5 of 39 GRADUATE STUDENT RESEARCH TALK 11:25 AM – 11:40 AM | Tomatis Auditorium Zach DeBruine, PhD Candidate – Van Andel Institute Graduate School Molecular and Cellular Biology Research Mentor: Karsten Melcher, PhD – Lead Investigator: Structural Biology and Biochemistry, Van Andel Institute . Scientific Talk Emphasis: Biochemistry . Co-Author(s): Karsten Melcher, PhD “Frizzled GPCRs initiate and amplify signaling through independent mechanisms” Membrane receptors are typically thought of as molecular switches which are flipped on and off upon ligand binding. However, the interactome around each of these proteins is exceedingly complex, and sometimes the activity of these receptors are carefully tuned by multiple regulatory pathways and activation mechanisms. A few years ago, we made the perplexing observation that Frizzled G-protein Coupled Receptors (GPCRs) lacking a ligand-binding domain were still able to signal. We investigated how this was possible, and learned that there are two independent mechanisms through which Frizzleds can either initiate, or amplify, signaling. This finding changes how we view Wnt pathway regulation and pharmacology. It is also yet another example of how perplexing observations should be explored, not ignored. Student Profile: https://vaigs.vai.org/students-alumni/students/zach-debruine/ Alumnus: Hope College, Bachelor of Science, Biochemistry and Molecular Biology, 2015 Page 6 of 39 UNDERGRADUATE STUDENT RESEARCH TALKS 11:40 AM – 12:10 PM | Tomatis Auditorium Svetlana Djirackor, Aquinas College Major(s): Biology Class of 2020 Research Mentor(s): L. Robert Peters, Jr., PhD – Associate Professor of Biology, Aquinas College . Scientific Talk Emphasis: Immunology . Co-Author(s): Lucas Topie and L. Robert Peters, Jr., PhD “Subcloning of zebrafish NOD1 alleles into UAS:P2A-nls-EGFP for investigation of NOD1’s role in hematopoietic stem cell development” Abstract: NOD1 is a dimeric pattern recognition receptor of the innate immune system, encoded by the NOD1 gene. This protein recognizes bacterial pathogens and, upon recognition, it is activated and initiates an immune response. NOD1 activation has been implicated in the mobilization of hematopoietic stem cells (HSCs) yet the underlying mechanism of this process remains elusive. To further explore the role of NOD1 in HSC development, we used the recombinational cloning system, In-Fusion® (Clontech) Cloning to subclone zebrafish dominant-negative NOD1 alleles (L36Q and K202R) formerly designed by our group and the NOD1 wild type allele (NOD1 WT) into the plasmid UAS:P2A-nls-EGFP. Our collaborators will use this plasmid, flanked by Tol2 recognition sites, to integrate the sequence of interest into the zebrafish genome and thus monitor the role of NOD1 in HSC development. Liam Ferraby, Calvin University Major(s): Environmental Studies Class of 2020 Research Mentor(s): Jason VanHorn, PhD – Assistant Professor and Department Co-Chair, Geology, Geography and Environmental Studies, Calvin University . Scientific Talk Emphasis: Immunology . Co-Author(s): Dr. Jason VanHorn, Dr. Kevin den Dulk, and Annalane Miller “The Science of Providing Services Spatially for Returning Citizens” Abstract: Resources available to returning citizens (released from prison) for locating service provider assistance are often difficult to use and incapable of providing the necessary support required for a successful reentry back into society. This problem generated a need for an improved method of providing returning citizens with the fundamental support vital to the success of the reentry process. Over the past three years, our team has developed a GIS based solution to improve the ability of returning citizens to find the service providers that
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