SKELETAL MUSCLE RECEPTORS Nerve Fiber Classification
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Of 100 1. the Golgi Tendon Organ Is an Essential Component of Static
1. The Golgi tendon organ is an essential component of static stretching because it A. increases muscle spindle activity in a tight muscle. Rationale A. Golgi tendon organs decrease muscle spindle activity. B. prevents muscles from stretching too far or too fast. Rationale B. Muscle spindles prevent muscles from stretching too far or too fast. C. increases contraction rate in muscle fibers. Rationale C. Holding a stretch creates tension in the muscle, which stimulates the Golgi tendon organ, causes relaxation of an overactive muscle, and allows optimal lengthening of tissue. D. prevents muscle from being placed under excessive tension.(correct) Rationale D. The Golgi tendon organ prevents muscles from being placed under excessive tension (autogenic inhibition). Question Name 1-1 Certification Thinking Skills Foundational Thinking Current Forms 2011 Practice A Primary Reference Chapter 7, Task 1A1 Page 1 of 100 2. Which of the following is the correct force-couple relationship that allows for the upward rotation of the scapula? A. Longus capitus and brachialis Rationale A. The longus capitus concentrically accelerates cervical flexion and lateral flexion, while the brachialis concentrically accelerates elbow flexion. B. Rhomboid minor and anterior scalenes Rationale B. The rhomboid minor concentrically accelerates scapular retraction and downward rotation, while the anterior scalenes concentrically accelerates cervical flexion, rotation, and lateral flexion. C. Sternocleidomastoid and longus coli Rationale C. The sternocleidomastoid concentrically accelerates cervical flexion, rotation, and lateral flexion while the longus coli concentrically accelerate cervical flexion, lateral flexion, and ipsilateral rotation. D. Upper trapezius and lower portions of the serratus anterior (correct) Rationale D. The upper trapezius and the lower portion of the serratus anterior are muscle groups that move together to produce upward rotation of the scapula. -
VIEW Open Access Muscle Spindle Function in Healthy and Diseased Muscle Stephan Kröger* and Bridgette Watkins
Kröger and Watkins Skeletal Muscle (2021) 11:3 https://doi.org/10.1186/s13395-020-00258-x REVIEW Open Access Muscle spindle function in healthy and diseased muscle Stephan Kröger* and Bridgette Watkins Abstract Almost every muscle contains muscle spindles. These delicate sensory receptors inform the central nervous system (CNS) about changes in the length of individual muscles and the speed of stretching. With this information, the CNS computes the position and movement of our extremities in space, which is a requirement for motor control, for maintaining posture and for a stable gait. Many neuromuscular diseases affect muscle spindle function contributing, among others, to an unstable gait, frequent falls and ataxic behavior in the affected patients. Nevertheless, muscle spindles are usually ignored during examination and analysis of muscle function and when designing therapeutic strategies for neuromuscular diseases. This review summarizes the development and function of muscle spindles and the changes observed under pathological conditions, in particular in the various forms of muscular dystrophies. Keywords: Mechanotransduction, Sensory physiology, Proprioception, Neuromuscular diseases, Intrafusal fibers, Muscular dystrophy In its original sense, the term proprioception refers to development of head control and walking, an early im- sensory information arising in our own musculoskeletal pairment of fine motor skills, sensory ataxia with un- system itself [1–4]. Proprioceptive information informs steady gait, increased stride-to-stride variability in force us about the contractile state and movement of muscles, and step length, an inability to maintain balance with about muscle force, heaviness, stiffness, viscosity and ef- eyes closed (Romberg’s sign), a severely reduced ability fort and, thus, is required for any coordinated move- to identify the direction of joint movements, and an ab- ment, normal gait and for the maintenance of a stable sence of tendon reflexes [6–12]. -
Neural Control of Movement: Motor Neuron Subtypes, Proprioception and Recurrent Inhibition
List of Papers This thesis is based on the following papers, which are referred to in the text by their Roman numerals. I Enjin A, Rabe N, Nakanishi ST, Vallstedt A, Gezelius H, Mem- ic F, Lind M, Hjalt T, Tourtellotte WG, Bruder C, Eichele G, Whelan PJ, Kullander K (2010) Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as mark- ers for fast motor neurons and partition cells. J Comp Neurol 518:2284-2304. II Wootz H, Enjin A, Wallen-Mackenzie Å, Lindholm D, Kul- lander K (2010) Reduced VGLUT2 expression increases motor neuron viability in Sod1G93A mice. Neurobiol Dis 37:58-66 III Enjin A, Leao KE, Mikulovic S, Le Merre P, Tourtellotte WG, Kullander K. 5-ht1d marks gamma motor neurons and regulates development of sensorimotor connections Manuscript IV Enjin A, Leao KE, Eriksson A, Larhammar M, Gezelius H, Lamotte d’Incamps B, Nagaraja C, Kullander K. Development of spinal motor circuits in the absence of VIAAT-mediated Renshaw cell signaling Manuscript Reprints were made with permission from the respective publishers. Cover illustration Carousel by Sasha Svensson Contents Introduction.....................................................................................................9 Background...................................................................................................11 Neural control of movement.....................................................................11 The motor neuron.....................................................................................12 Organization -
Interpretation of Sensory Information from Skeletal Muscle Receptors for External Control Milan Djilas
Interpretation of Sensory Information From Skeletal Muscle Receptors For External Control Milan Djilas To cite this version: Milan Djilas. Interpretation of Sensory Information From Skeletal Muscle Receptors For External Control. Automatic. Université Montpellier II - Sciences et Techniques du Languedoc, 2008. English. tel-00333530 HAL Id: tel-00333530 https://tel.archives-ouvertes.fr/tel-00333530 Submitted on 23 Oct 2008 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. UNIVERSITE MONTPELLIER II SCIENCES ET TECHNIQUES DU LANGUEDOC T H E S E pour obtenir le grade de DOCTEUR DE L'UNIVERSITE MONTPELLIER II Formation doctorale: SYSTEMES AUTOMATIQUES ET MICROELECTRONIQUES Ecole Doctorale: INFORMATION, STRUCTURES ET SYSTEMES présentée et soutenue publiquement par Milan DJILAS le 13 octobre 2008 Titre: INTERPRETATION DES INFORMATIONS SENSORIELLES DES RECEPTEURS DU MUSCLE SQUELETTIQUE POUR LE CONTROLE EXTERNE INTERPRETATION OF SENSORY INFORMATION FROM SKELETAL MUSCLE RECEPTORS FOR EXTERNAL CONTROL JURY Jacques LEVY VEHEL Directeur de Recherches, INRIA Rapporteur -
Characterization of Cecal Smooth Muscle Contraction in Laying Hens
veterinary sciences Communication Characterization of Cecal Smooth Muscle Contraction in Laying Hens Katrin Röhm 1, Martin Diener 2 , Korinna Huber 1 and Jana Seifert 1,* 1 Institute of Animal Science, University of Hohenheim, 70593 Stuttgart, Germany; [email protected] (K.R.); [email protected] (K.H.) 2 Institute of Veterinary Physiology and Biochemistry, Justus-Liebig University, 35392 Gießen, Germany; [email protected] * Correspondence: [email protected] Abstract: The ceca play an important role in the physiology of the gastrointestinal tract in chickens. Nevertheless, there is a gap of knowledge regarding the functionality of the ceca in poultry, especially with respect to physiological cecal smooth muscle contraction. The aim of the current study is the ex vivo characterization of cecal smooth muscle contraction in laying hens. Muscle strips of circular cecal smooth muscle from eleven hens are prepared to investigate their contraction ex vivo. Contraction is detected using an isometric force transducer, determining its frequency, height and intensity. Spontaneous contraction of the chicken cecal smooth muscle and the influence of buffers (calcium-free buffer and potassium-enriched buffer) and drugs (carbachol, nitroprusside, isoprenaline and Verapamil) affecting smooth muscle contraction at different levels are characterized. A decrease in smooth muscle contraction is observed when a calcium-free buffer is used. Carbachol causes an increase in smooth muscle contraction, whereas atropine inhibits contraction. Nitroprusside, isoprenaline and Verapamil result in a depression of smooth muscle contraction. In conclusion, the present results confirm a similar contraction behavior of cecal smooth muscles in laying hens as Citation: Röhm, K.; Diener, M.; shown previously in other species. -
Electromagnetic Field and TGF-Β Enhance the Compensatory
www.nature.com/scientificreports OPEN Electromagnetic feld and TGF‑β enhance the compensatory plasticity after sensory nerve injury in cockroach Periplaneta americana Milena Jankowska1, Angelika Klimek1, Chiara Valsecchi2, Maria Stankiewicz1, Joanna Wyszkowska1* & Justyna Rogalska1 Recovery of function after sensory nerves injury involves compensatory plasticity, which can be observed in invertebrates. The aim of the study was the evaluation of compensatory plasticity in the cockroach (Periplaneta americana) nervous system after the sensory nerve injury and assessment of the efect of electromagnetic feld exposure (EMF, 50 Hz, 7 mT) and TGF‑β on this process. The bioelectrical activities of nerves (pre‑and post‑synaptic parts of the sensory path) were recorded under wind stimulation of the cerci before and after right cercus ablation and in insects exposed to EMF and treated with TGF‑β. Ablation of the right cercus caused an increase of activity of the left presynaptic part of the sensory path. Exposure to EMF and TGF‑β induced an increase of activity in both parts of the sensory path. This suggests strengthening efects of EMF and TGF‑β on the insect ability to recognize stimuli after one cercus ablation. Data from locomotor tests proved electrophysiological results. The takeover of the function of one cercus by the second one proves the existence of compensatory plasticity in the cockroach escape system, which makes it a good model for studying compensatory plasticity. We recommend further research on EMF as a useful factor in neurorehabilitation. Injuries in the nervous system caused by acute trauma, neurodegenerative diseases or even old age are hard to reverse and represent an enormous challenge for modern medicine. -
The Muscular System
THE MUSCULAR SYSTEM COMPILED BY HOWIE BAUM 1 Muscles make up the bulk of the body and account for 1/3 of its weight.!! Blood vessels and nerves run to every muscle, helping control and regulate each muscle’s function. The muscular system creates body heat and also moves the: Bones of the Skeletal system Food through Digestive system Blood through the Circulatory system Fluids through the Excretory system MUSCLE TISSUE The body has 3 main types of muscle tissue 1) Skeletal, 2) Smooth, and 3) Cardiac SKELETAL MUSCLE SMOOTH MUSCLE CARDIAC MUSCLE Skeletal muscles attach to and move bones by contracting and relaxing in response to voluntary messages from the nervous system. Skeletal muscle tissue is composed of long cells called muscle fibers that have a striated appearance. Muscle fibers are organized into bundles supplied by blood vessels and innervated by motor neurons. Muscle structure Skeletal (striated or voluntary) muscle consists of densely packed groups of hugely elongated cells known as myofibers. These are grouped into bundles (fascicles). A typical myofiber is 2–3 centimeters ( 3/4–1 1/5 in) long and 0.05millimeters (1/500 inch) in diameter and is composed of narrower structures – myofibrils. These contain thick and thin myofilaments made up mainly of the proteins actin and myosin. Numerous capillaries keep the muscle supplied with the oxygen and glucose needed to fuel contraction. Skeletal Muscles • Skeletal muscles attach to bones by tendons (connective tissue) and enable movement. • Skeletal muscles are mostly voluntary Feel the back of your ankle to feel your Achilles tendon - the largest tendon in your body. -
ALS and Other Motor Neuron Diseases Can Represent Diagnostic Challenges
Review Article Address correspondence to Dr Ezgi Tiryaki, Hennepin ALS and Other Motor County Medical Center, Department of Neurology, 701 Park Avenue P5-200, Neuron Diseases Minneapolis, MN 55415, [email protected]. Ezgi Tiryaki, MD; Holli A. Horak, MD, FAAN Relationship Disclosure: Dr Tiryaki’s institution receives support from The ALS Association. Dr Horak’s ABSTRACT institution receives a grant from the Centers for Disease Purpose of Review: This review describes the most common motor neuron disease, Control and Prevention. ALS. It discusses the diagnosis and evaluation of ALS and the current understanding of its Unlabeled Use of pathophysiology, including new genetic underpinnings of the disease. This article also Products/Investigational covers other motor neuron diseases, reviews how to distinguish them from ALS, and Use Disclosure: Drs Tiryaki and Horak discuss discusses their pathophysiology. the unlabeled use of various Recent Findings: In this article, the spectrum of cognitive involvement in ALS, new concepts drugs for the symptomatic about protein synthesis pathology in the etiology of ALS, and new genetic associations will be management of ALS. * 2014, American Academy covered. This concept has changed over the past 3 to 4 years with the discovery of new of Neurology. genes and genetic processes that may trigger the disease. As of 2014, two-thirds of familial ALS and 10% of sporadic ALS can be explained by genetics. TAR DNA binding protein 43 kDa (TDP-43), for instance, has been shown to cause frontotemporal dementia as well as some cases of familial ALS, and is associated with frontotemporal dysfunction in ALS. Summary: The anterior horn cells control all voluntary movement: motor activity, res- piratory, speech, and swallowing functions are dependent upon signals from the anterior horn cells. -
Fine Structure of the Receptors at the Myotendinous Junction of Human Extraocular Muscles
Histol Histopath (1 988) 3: 103-113 Histology and Fine structure of the receptors at the myotendinous junction of human extraocular muscles A. Sodii, M. Corsii, M.S. Faussone Pellegrini2and G. Salvii 'Eye Clinic, Chair of Physiopathological Optics and Departrnent of Hurnan Anatorny and Histology, Section of Histology, University of Florence, ltaly Summary. The myotendinous junction of the human lntroduction extraocular muscles was studied by electron microscopy. Some peculiar receptorial structures have been found in The proprioceptors known as tendon organs were first the majority of the samples examined. These structures identified by Golgi in 1880 in skeletal muscles. They were are very small and consist of 1) the terminal portion of first described at electron microscope level by Merrillees one muscle fibre, 2) the tendon into which it inserts and in 1962 and later by other authors (Schoultz and Swett, y), within the tendon, a rich nerve arborization, whose 1972, 1974; Barker, 1974: Zelena and Soukup, 1977; branches are always very close to the rnuscle component. Soukup and Zelena, 1985; Ovalle and Dow, 1983). In the Only one discontinuous layer, made up of tlat cells. extraocular muscles (EOM) the presence of tendon which lack a basa1 lamina and often show pinocytotic organs was first excluded by Golgi himself, but further vesicles, encapsules every musculo-tendinous complex. investigations (Dogiel. 1906: Loffredo-Sampaolo, 1952; The tendinous component consists of amorphous ground Bonavolonta, 1956, 1958) led to their identification and substance of different electron density. of collagen and description at light microscopy level in several animal elastic fibres and is divided in compartments by ramified species. -
Skeletal Muscle Physiology
This document was created by Alex Yartsev ([email protected]); if I have used your data or images and forgot to reference you, please email me. Skeletal Muscle Physiology First of all, which muscle is which - Skeletal muscle: o Well-developed cross-striations o Does not contract in absence of a nerve stimulus o The individual muscle fibers DO NOT connect functionally or anatomically (i.e. they don’t form a single sheet of cells, and one fiber’s action potential wont get transmitted to the next) o Generally, skeletal muscle is under voluntary control - Cardiac muscle: o Also has cross-striations o Is functionally syncytial: cells are connected well enough to conduct action potentials to one another o Can contract on its own, without stimulus (but this is under some control via the autonomic nervous system, which modulates its activity) - Smooth muscle: o Has no cross-striations o Two broad types: . VISCERAL or “unitary” smooth muscle: Functionally syncytial, action potentials propagate from cell to cell Contains pacemakers which discharge irregularly, but remains under control of the autonomic nervous system Found in most hollow viscera . MULTI-UNIT SMOOTH MUSCLE Found in the eye and some other locations Does NOT activate spontaneously SKELETAL MUSCLE ORGANIZATION - Each muscle is a bundle of fibers - Each fiber is a long, multinucleated single cell - Each fiber is surrounded by a SARCOLEMMA- the cell membrane - There are NO SYNCYTIAL BRIDGES between the cells. When one cell goes off, the others don’t follow. TRANSVERSE TUBULES: T-tubules, invaginations of SARCOLEMMA: the muscle cell membrane the sarcolemma, they form part of the T-system; the space inside is an extension of the extracellular space. -
Back-To-Basics: the Intricacies of Muscle Contraction
Back-to- MIOTA Basics: The CONFERENCE OCTOBER 11, Intricacies 2019 CHERI RAMIREZ, MS, of Muscle OTRL Contraction OBJECTIVES: 1.Review the anatomical structure of a skeletal muscle. 2.Review and understand the process and relationship between skeletal muscle contraction with the vital components of the nervous system, endocrine system, and skeletal system. 3.Review the basic similarities and differences between skeletal muscle tissue, smooth muscle tissue, and cardiac muscle tissue. 4.Review the names, locations, origins, and insertions of the skeletal muscles found in the human body. 5.Apply the information learned to enhance clinical practice and understanding of the intricacies and complexity of the skeletal muscle system. 6.Apply the information learned to further educate clients on the importance of skeletal muscle movement, posture, and coordination in the process of rehabilitation, healing, and functional return. 1. Epithelial Four Basic Tissue Categories 2. Muscle 3. Nervous 4. Connective A. Loose Connective B. Bone C. Cartilage D. Blood Introduction There are 3 types of muscle tissue in the muscular system: . Skeletal muscle: Attached to bones of skeleton. Voluntary. Striated. Tubular shape. Cardiac muscle: Makes up most of the wall of the heart. Involuntary. Striated with intercalated discs. Branched shape. Smooth muscle: Found in walls of internal organs and walls of vascular system. Involuntary. Non-striated. Spindle shape. 4 Structure of a Skeletal Muscle Skeletal Muscles: Skeletal muscles are composed of: • Skeletal muscle tissue • Nervous tissue • Blood • Connective tissues 5 Connective Tissue Coverings Connective tissue coverings over skeletal muscles: .Fascia .Tendons .Aponeuroses 6 Fascia: Definition: Layers of dense connective tissue that separates muscle from adjacent muscles, by surrounding each muscle belly. -
Structure of a Skeletal Muscle
STRUCTURE OF A SKELETAL MUSCLE Skeletal muscles are not made of muscle cells alone • Skeletal muscle contains blood vessels that supply muscle cells with oxygen and glucose, and remove wastes, and nerves that coordinate muscle contraction • 1 § Each individual muscle cell (fiber) is surrounded by the _____________ § Several muscle cells are bundled together into a _________ by the _____________ § All fascicles that make up a muscle are, in turn, enclosed by the _____________ § Interconnected connective tissues taper down and connect to tendons or other connective tissues; attach muscle to bone or other structure to be moved Figure 9.1 Position and structure of a skeletal muscle. 2 FUNCTIONS OF SKELETAL MUSCLES • Muscle contractions are involved in more than just movement of bones at a joint: § § Contraction of diaphragm muscle is a vital function associated with respiratory system § _________________ – sitting, standing, holding head upright § Skeletal muscles attached to facial skin allow for facial expression; muscles in throat assist with swallowing § Sphincters composed of skeletal muscle allow conscious control over opening and closing of body openings § Support of soft tissue – abdominal walls, pelvic floor 3 • Functional groups of muscles: generally takes cooperation of several individual muscles working as a group to perform a movement or action § __________________ provide most force for a given muscle action § _____________have opposite action of agonist; allows for modulation and control of agonist movement § _____________aid agonists by supplying supplemental force, minimizing unwanted movement, and by helping to stabilize joints § _____________also provide stabilizing force that anchors a bone; protection from injury due to unnecessary movements Figure 9.3 Functional groups of muscles.