The content in this document was updated on June 13. For the most up-to-date information, CLICK HERE. Boston, Massachusetts Annual Meeting TH Boston Convention & 44 Exhibition Center June 22-26, 2008 PROGRAM CHAIRPERSON Jeffrey W. Sherman, MD, FACP IDM Pharma, Inc. Program Chairperson Boston – The City of Firsts As our nation’s oldest major city, Boston is home to the first: • University Medical Firsts: • Public school • First time ether was used as an anesthetic during an • Public Health operation at Massachusetts Commission General Hospital in 1846 • Subway station • First kidney transplant performed in 1954 • Free library • First pediatric open heart • Paid fire and police surgery performed at departments Children's Hospital in 1967 Jeffrey (Jeff) W. Sherman, MD, FACP, Chief Medical Officer and Senior Vice President of Research & Development, IDM Pharma, Inc. Before joining IDM Pharma, Jeff was Vice President of Clinical Science at Takeda Global Research and Development. He has also worked as the Chief Medical Officer and Executive Vice President at NeoPharm, Inc. He has also held positions at Searle/Pharmacia Research and Development, including Director, Senior Director, and Executive Director of Clinical Research. There he managed clinical development activities for a variety of therapeutic areas, including infectious diseases, women’s health, sleep, and central nervous system. Jeff went on to lead company-wide oncology clinical research as Executive Director, Clinical Research and then oncology medical marketing as Head, Oncology Global Medical Operations. Prior to joining Searle/Pharmacia, Jeff worked at Bristol-Myers Squibb in clinical pharma- cology and clinical research. Jeff received his MD from Rosalind Franklin University/Chicago Medical School. He completed an internship and resi- dency in internal medicine at Northwestern University, where he served as chief medical resident. Additionally, he completed a fellowship in infectious diseases with an interest in immunocompromised patients at the University of California-San Francisco (UCSF) and was a research associate in allergy and immunology at the Howard Hughes Medical Institute at UCSF. Jeff is an Adjunct Assistant Professor of Medicine at the Northwestern University Feinberg School of Medicine, Diplomat of the National Board of Medical Examiners and American Board of Internal Medicine, and a member of the DIA Board of Directors. He received a DIA Outstanding Service Award in 2001. Table of Contents 1 Chairperson’s Message 9 Getting to, and around, Boston 115 Exhibiting Companies 2 Keynote Speakers 10 General Information 137 Tutorial Pricing Guide Dennis A. Ausiello, MD, Harvard Medical School/ including Continuing Education and Massachusetts General Hospital Contact Information 138 Hotel Information Kathy Giusti, MBA, Multiple Myeloma Research Hotel Reservation Form, Please monitorFoundation/Multiple www.diahome.org Myeloma Researchfor program Consortium updates and12 onlineTutorials registration. Hotel Locator Map 3 Program Committee 25 Meeting Schedule 140 Optional Tours 4 Networking Reception Session Details Tour Descriptions 6 Meeting Highlights 32 Saturday, June 21 – Monday, June 23 143 Tour Reservation Form Multitrack Plenary Session, Hot Topics, Megatracks 53 Tuesday, June 24 144 Attendee Registration Form 8 About the Annual Meeting/ 78 Wednesday, June 25 Benefits of Membership 105 Thursday, June 26 Invitation to DIA’s 44th Annual Meeting June 22-26, 2008 Boston, MA, USA Dear Colleague, Welcome to Boston, a major national and international city of technology, science, and higher education, making it an attractive location for information technology, research and development, and biotechnology companies. Oliver Wendell Holmes called it "The Hub of the Universe." It has also been deemed "The Athens of America." To many it is known as "Beantown." Whatever name you choose, Boston is a unique city that has played a major role in the American experience. More than 90 colleges and universities call the greater Boston area home–a higher concentration than any other part of the world. From distinguished physicians and medical researchers, to world-class athletes and per- formers, Boston is a host to some of the world's most elite and accomplished people. It is only fitting that DIA has chosen Boston as the site for its 44th Annual Meeting. Like Boston, the DIA Annual Meeting is rich in history, forward thinking, passionate, and intellectually stimulating; there is something for everyone. The DIA Annual Meeting rep- resents the most significant means for advancing our objectives via our multidisciplinary focus, international reach, and neutral forums. The 44th Annual Meeting will offer innov- ative ideas, provide answers to new questions, and help the pharmaceutical industry redefine the development, regulation, surveillance, and marketing of pharmaceuticals. This year’s event features keynote addresses by Dennis A. Ausiello, MD, Jackson Professor of Clinical Medicine at Harvard Medical School and Chief of Medicine at Massachusetts General Hospital (MGH), and Kathy Giusti, Founder and Chief Executive Officer, Multiple Myeloma Research Foundation (MMRF) and Multiple Myeloma Research Consortium (MMRC). Dr. Ausiello is a nationally recognized leader in academic medicine who has made significant contributions to epithelial biology, particularly in the areas of membrane protein trafficking, ion channel regulation, and signal transduction. Ms. Giusti is world renowned for her tireless work on behalf of multiple myeloma research. Conference participants will benefit from nearly 400 sessions across 26 content-area tracks, with more than 1,000 speakers, and over 450 exhibitors showcasing the indus- try’s latest products and services. Networking is also a hallmark of the DIA Annual Meeting–from the daily continental breakfasts and afternoon refreshment breaks to the more formal Networking Receptions. Your invitation to participate is an invitation to explore the very heart of our work. See you in Boston! Jeffrey (Jeff) W. Sherman, MD, FACP 44th Annual Meeting Program Chair “The meeting far exceeded my expectations. It is THE BEST professional conference I have attended in recent years.” 1 2007 Annual Meeting Attendee Plenary Session Keynotes Dennis A. Ausiello, MD, is the Jackson Professor of Clinical Medicine at Harvard Medical School, and Chief of Medicine at Massachusetts General Hospital (MGH). He received his undergraduate degree from Harvard College and his medical degree from the University of Pennsylvania. He has made a sub- stantial contribution to knowledge of epithelial biology in the areas of membrane protein trafficking, ion channel regulation and signal transduction. He has published numerous articles, book chapters, and textbooks and served as the co-editor of Cecil’s Textbook of Medicine, in its 22nd and 23rd edition. A nationally recognized leader in academic medicine, Dr. Ausiello was elected to the Institute of Medi- ine of the National Academy of Science in 1999 and the American Academy of Arts and Sciences in 2003. He has written for the New York Times, the Wall Street Journal, and the Boston Globe on health sub- jects, including human genetics, clinical trials, and the relationship between the academy and industry. Dr. Ausiello served as Chief of the MGH Renal Unit and oversaw its development into one of the most sought after research and training programs in the world. As Chief of Medicine at Massachuetts General Hospital, a position he has held since 1996, he leads one of the strongest Departments of Medicine in the country with a clinical, research and education budget exceeding $500 million annually. He is closely involved with the Partners HealthCare System, linking the resources of the Massachusetts - General Hospital, Brigham and Women’s Hospital, and Dana-Farber Cancer Institute to provide com- prehensive health care. He oversees the training of more than 150 house officers, 500 graduate students and postdoctoral fellows, and dozens of students at Harvard Medical School, many of whom have gone on to careers as physician-scientists. Dr. Ausiello was also Director of the MD/PhD Program at Harvard Medical School and the Massachusetts Institute of Technology until 1999. He served as Chairman of the Executive Committee on Research of the Massachusetts General Hospital where he oversaw a research budget of $350 million annually. As an internationally recognized scientist, Dr. Ausiello has been the recipient of two MERIT awards from the National Institutes of Health and has served as a council member of the National Institute of Diabetes, Digestive and Kidney Diseases Advisory Council and the National Advisory Council on Aging. Understanding the need for partnerships between the academy and industry, Dr. Ausiello also serves in a variety of advisory roles beyond his aca- demic affiliations. Dr. Ausiello serves on the Board of Directors of Pfizer, Inc., and MicroCHIPS, a drug-sensing and delivery company. In addition, Dr. Ausiello is also a member of the Scientific Advisory Boards of Promedior, Proventys and Pulmatrix. Dr. Ausiello is particularly interested in the training of inquisitive physicians and translational investigators, and is the architect and director of the recently implemented Harvard initiative in Patient-Associated Science: Training, Education, Understanding, and Research (PASTEUR) – a novel edu- cational program designed to introduce Harvard medical students and select Harvard undergraduates and graduate students to the excitement,