www.pharmtech.com

years 1977– 2007

30ANNIVERSARY

CELEBRATING 30 YEARS AS THE 2007 INDUSTRY’S MOST AUTHORITATIVE SOURCE Media Planner years 1977–2007 ANNIVERSARY years 1977–2007 ANNIVERSARY

THE PHARMACEUTICAL TECHNOLOGY BRAND

PUBLISHER’S STATEMENT Pharmaceutical Technology’s authoritative reputation and powerful brand recognition within the pharmaceutical/biopharmaceutical development & manufacturing marketplace will help you establish and maintain your own strong brand among pharma industry decision makers. A circulation of 38,667 BPA-qualified subscribers* and unmatched peer written and reviewed editorial make Pharmaceutical Technology an invaluable resource within top pharma companies, as well as small, specialty and biotech pharma companies spending billions each year on pharmaceutical development and manufacturing.

Please celebrate with us as Pharmaceutical Technology marks its 30th Anniversary as the industry leader. —Michael Tracey, Publisher % 90 of readers rated Pharmaceutical Technology as important or very important to them as a professionalˆ

EDITORIAL MISSION Pharmaceutical Technology publishes authoritative, reliable, and timely peer-reviewed research and expert analyses for scientists, engineers, technicians, and managers engaged in process development, manufacturing, formulation, analytical technology, packaging and regulatory compliance in the pharmaceutical and biotechnology industries. —Douglas McCormick, Editor in chief

www.pharmtech.com

*BPA June 2006 Statement ^2006 Readership Study Conducted by Advanstar Research Services years 1977–2007 ANNIVERSARY

THE PHARMACEUTICAL TECHNOLOGY AUDIENCE: CIRCULATION

Over the years, Pharmaceutical Technology has built and grown a circulation of 38,667 BPA-qualified subscribers*. We’ve cornered the market on R&D, QA/QC, Production/Manufacturing/Engineering and related job functions at top Pharma and Biotech manufacturing companies.

REACH INDUSTRY LEADERS AT TOP COMPANIES [# OF SUBSCRIBERS]**

Pfizer 1368 Hoffman-LaRoche 143 73 Ben Venue 53 974 Barr Labs 140 Medimmune 72 Icos 52 Abbott 792 Proctor & Gamble 138 71 Thermo 52 Eli Lilly 761 3M 135 American Pharma Partners 70 Cima Labs 50 Merck 757 Chiron 130 Nektar Therapeutics 70 Lancaster Labs 50 627 129 69 Sigma Aldrich 50 Bristol-Myers Squibb 586 Dow 115 KOS 66 Merial 49 Schering-Plough 569 110 PPD Inc. 65 KV Pharmaceutical 48 GlaxoSmithKline 547 107 SchwartzSchwarz PharmaPharma 64 47 436 Forest 102 63 Protein Design Labs 47 Bayer 342 Berlex 96 Solvay 63 Saic Frederick 47 Cardinal Health 269 Cambrex Bio Science 93 Bausch & Lomb 62 Upsher-Smith 47 Watson 269 Teva 92 Imclone 62 Dey Labs 46 Novartis 259 Tyco 89 MDS 62 DPT Labs 46 255 Alpharma 85 Lonza 61 GE Healthcare 46 AstraZeneca 226 Gilead 83 DSM Pharmaceuticals 60 Organon 46 Johnson & Johnson 216 Ivax 82 Diosynth 59 Guidant 43 Genzyme 203 Andrx 80 Jacobs Engineering 59 Purdue Frederick 42 Boehringer Ingelheim 196 AAI Pharma 79 Millennium 58 Banner Pharma 38 Sanofi-Aventis 185 Eisai 78 Boston Scientic 57 Steris 38 Alza 184 Human Genome Sciences 77 Quintiles 57 Biovail 34 Centocor 182 Regeneron 77 Millipore 56 Takeda 31 160 Shire Laboratories 76 Patheon 56 Colorcon 30 163 Waters 76 Roxane Pharmaceutical 56 Novo Nordisk 30 148 Elan Corp. 75 Fluor Daniel 54

BUSINESS AND INDUSTRY* IN A VARIETY OF JOB FUNCTIONS*

75.5 % Research, Development, Formulation 34.9% Pharmaceutical & Quality Control, Assurance Validation 18.8 % Biopharmaceutical Manufacturing Engineering 12.4 %

Production Manufacturing 9.5 % 6.1 % 1.5 % 2.5% Corporate Management Specialty Chemicals, Technical, Analytical Service, 3.3 % Other Paid Circulation: Bulk Products & Support Subscriptions Raw Material Producers Marketing and 2.7 % Sales Management 3.8 % Regulatory Affairs 2.7 % 2.5 % University, Lab Management 3.0 % Research Institute, Consultant to the Foundation Project Management, 2.3 % Pharmaceutical Procurement Contract Management Industry 6.6 % Contract Research, 3.3 % Information Technology 1.0 % Analytical, Drug Delivery Devices & 1.7 % Manufacturing Instrumentation Manufacturing Materials Management/Purchasing 0.8 % Services Architecture/ Other Functions Allied to the Field 2.5 % Engineering/ 2.6 % and Other Paid Circulation Construction Government

*BPA June 2006 Statement. Numbers are a percentage of 36,648 total qualified subscribers. **Publisher’s Own Data years 1977–2007 ANNIVERSARY

THE PHARMACEUTICAL TECHNOLOGY AUDIENCE: CIRCULATION

PHARMACEUTICAL TECHNOLOGY DELIVERS THE LARGEST AVERAGE QUALIFIED CIRCULATION WITH THE HIGHEST NUMBER OF DIRECT REQUEST SUBSCRIPTIONS*

ring u uring fact u ufact lation est est u Man Man u u ulation m m

alified Circ u a/Biophar a/Biophar Year ualified Circ m m ree Year har f One Year f Total Direct Req Total Q Average Q # P % Phar # R&D/QA/QC% R&D/QA/QC# o % of One Year# of Two % of Two Year# of Three% Year of Th # o % of Total Direct Req

Pharmaceutical Technology 38,648 38,667 29,173 75.5% 20,744^ 53.7% 33,158 85.8% 5,490 14.2% 0 0.0% 34,854 90.2% American Pharmaceutical Outsourcing 13,983 14,134 6,805** 48.5%** 5,345 38.2% 5,907 42.3% 5,945 42.5% 2,131 15.2% 13,950 99.8%

American Pharmaceutical Review 29,978 30,067 14,436** 48.2%** 17,681 59.0% 10,855 36.2% 15,020 50.1% 4,103 13.7% 22,983 76.6%

Contract Pharma 20,000 20,090 9,487 47.4% 7,381^^ 36.9% 15,007 75.0% 4,993 25.0% 0 0.0% 19,151 95.8%

Drug Delivery Technology Not Audited Not Audited

Pharmaceutical Formulation Not Audited Not Audited & Quality

Pharmaceutical Processing 31,020 31,020 25,050*** 80.8%*** 11,915 38.4% 24,823 80.0% 6,197 20.0% 0 0.0% 27,708 89.4%

Tablets & Capsules 10,048 9,776 6,304** 62.7%** 3,444 34.3% 8,561 85.2% 1,487 14.8% 0 0.0% 8,111 80.7%

Please note that R&D and QA/QC functions have been added together

*BPA June 2006 Statements; **Pharmaceutical Manufacturing; ***Pharmaceutical Manufacturing, Bio Pharmaceutical Mfg., Nutritional/Nutraceutical Products Mfg. ^R&D/Formulation/QA/QC/Validation; ^^R&D/QA/QC/Validation; †2006 Readership Study Conducted by Advanstar Research Services

Readers state why Pharmaceutical Technology is the industry’s #1 magazine: “Good combination of scientific and regulatory information.” –Rich Sternal, Sr. Scientist, Schering Plough “Contains general info on pharmaceuticals, trends, analytical methods, lab instruments.” –Aurea Almazan, Chemist, Merck & Co.

of readers state that Pharmaceutical Technology helps them stay 87% current in their profession† years 1977–2007 ANNIVERSARY

PHARMACEUTICAL TECHNOLOGY: LEADING THE WAY

Pharmaceutical Technology readers work for companies with an average department budget of $17 MILLION^ for purchasing pharmaceutical equipment and services over the next 12 months

MANUFACTURING/PROCESSING EQUIPMENT PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

Filtration/Separation 50 %

Mixing/Blending/Drying 49 %

Tablet Presses 44 %

Coating 44 % The leader in MANUFACTURING/ Pumps 42 % PROCESSING EQUIPMENT PAT/Process Control 41 % 62% of Pharmaceutical Technology readers Fluid-Bed 38 % Material Handling 37 % expressed involvement in purchasing QA/QC 35 % Manufacturing/Processing Equipment Capsule Filling Machinery 29 %

Bioprocessing 27 % for their company.

Lyophilizers/Freeze Dryers 23 %

Soft Gel Mfg 7 %

OUTSOURCED SERVICES PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

The leader in OUTSOURCED Consulting 50 % SERVICES Compliance & Validation 48 % 64% Manufacturing of Pharmaceutical Technology 46 % Labs 44 % readers expressed involvement in Research 42 % purchasing Outsourced Services Packaging 35 % for their company.

*2005 Market Study Conducted by The Wayman Group ^2006 Readership Study Conducted by Advanstar Research Services years 1977–2007 ANNIVERSARY

PHARMACEUTICAL TECHNOLOGY: LEADING THE WAY

CHEMICALS, EXCIPIENTS AND APIS PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

50 % Raw Materials 76 % The leader in CHEMICALS, EXCIPIENTS and APIs Excipients 65 % 65% of Pharmaceutical Technology

APIs 57 % readers expressed involvement in purchasing Chemicals, Excipients Bulk Chemicals 56 % and APIs for their company.

The leader in COMPLIANCE & VALIDATION 60% of Pharmaceutical Technology readers expressed involvement in purchasing Compliance & Validation Software Products and Services for their company.

COMPLIANCE & VALIDATION SOFTWARE PRODUCTS AND SERVICES PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

21 CFR Part 11 Compliance 61 %

QA Validation 54 %

Consulting 52 %

Document Management 46 %

Process Control/MES 28 %

ERP 9 %

10.6 % 9.7 % 1 Year Less than 1 Year 16.1 % 9.2 % Subscribers of Pharmaceutical 2 Years 15 Years or More Technology have been loyal readers 12.9 % for an average of 6 yearsˆ 19.8 % 10 to 14 Years 3 to 4 Years 21.7 % 5 to 9 Years

*2005 Market Study Conducted by The Wayman Group ^2006 Readership Study Conducted by Advanstar Research Services years 1977–2007 ANNIVERSARY

PHARMACEUTICAL TECHNOLOGY: LEADING THE WAY

The leader in DRUG DELIVERY TECHNOLOGY 50% of Pharmaceutical Technology readers expressed involvement in purchasing Drug Delivery Technology products and services for their company.

DRUG DELIVERY TECHNOLOGIES PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

Solid Dosage 58% Transdermal Patches/Components 23% Capsules, Hard & Soft 41% Nasal 20% Parenterals 37% Aerosols 15% Syringes 28% Inhalation 15%

LABORATORY EQUIPMENT PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

The leader in Balances & Scales 76% Chromatography 63% LABORATORY Temperature Instrumentation/Thermometers 57% EQUIPMENT of Spectrometers 57% 74% Tubing/Piping/Glassware 56% Pharmaceutical Technology readers Centrifuges/Stirrers 55% Sample Preparation Instrumentation 44% expressed involvement in purchasing Viscometers 34% Laboratory Equipment for their company.

*2005 Market Study Conducted by The Wayman Group years 1977–2007 ANNIVERSARY

PHARMACEUTICAL TECHNOLOGY: LEADING THE WAY

The leader in ASEPTIC/STERILE PROCESSING 38% of Pharmaceutical Technology readers expressed involvement in purchasing Aseptic/Sterile Processing products for their company.

ASEPTIC/STERILE PROCESSING PRODUCTS AND SERVICES PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

Cleanroom Equipment 74% HVAC Equipment/Filters 37% Sanitizing/Cleaning Agents 41% Terminal Sterilization Equipment 35% Barrier/Isolation Systems 41% Particle/Microbe Counters 34% Gloveboxes 39% Entry Systems 25% Cleanroom Garments, Gloves, Supplies 37%

The leader in PACKAGING 46% of Pharmaceutical Technology readers expressed involvement in purchasing Packaging products, supplies and equipment for their company.

PACKAGING PRODUCTS PURCHASED BY PHARMACEUTICAL TECHNOLOGY READERS*

Packaging Equipment 69% Machine Vision Inspection 31% Bottle Filling/Capping/Sealing 50% Ampule & Vial Filling/Sealing 30% Liquid Filling Equipment 47%

of subscribers 55.8 % 90.7% Stayed the Same stated that their reading of Pharmaceutical Technology has increased or stayed the same 34.9 % over the last several years^ Increased 9.3 % Decreased

*2005 Market Study Conducted by The Wayman Group ^2006 Readership Study Conducted by Advanstar Research Services years 1977–2007 ANNIVERSARY

CONTRIBUTING INDUSTRY EXPERTS AND COLUMNS

INDUSTRY-LEADING EDITORIAL Pharmaceutical Technology's content clearly dominates the field. Every month and every week, Pharmaceutical Technology reports on the technologies, strategies, and regulations crucial to professionals manufacturing pharmaceuticals and biopharmaceuticals, covering topics ranging from process and formulation development through unit-process optimization and manufacturing operations to packaging, labeling, and distribution.

Pharmaceutical Technology's staff and regular contributors are experts with long experience and deep knowledge of the field. They know the current conditions, forecast the trends, and are dedicated to delivering authoritative, expert-written and peer- reviewed technical content, in print and online.

OUTSOURCING OUTLOOK Published Monthly “Pharmaceutical Technology pioneered Timely insights into trends and challenges facing contract coverage of the pharmaceutical contract service providers and users from columnist and editorial advisory board member James C. Miller, MBA, founder and services industry. No other publication is president of PharmSource Information Services, Inc. A as effective in addressing the interests preeminent expert in bio/pharmaceutical outsourcing, Jim of both the business and technical established the pharmaceutical outsourcing industry’s principal information database, PharmSource.com, and is editor and decision makers.” publisher of the monthly online newsletter, Bio/Pharmaceutical Jim Miller Outsourcing Report. He holds an MBA from Stanford University. – Jim Miller “With its regular Packaging Forum column and other packaging- PACKAGING FORUM related content, Pharmaceutical Published in March, April, June, August, September, & October Pharmaceutical packaging expert Hallie Forcinio covers packaging Technology delivers the most equipment, containers, systems and materials with special current information about all attention to product protection (counterfeit prevention, child three ingredients needed for resistance, tamper evidence), stability, cold chain management, labeling, regulatory changes and other timely topics. Hallie Forcinio product success: R&D, has reported on innovations in pharmaceutical packaging since processing and packaging.” 1982. A former editor of Food and Drug Packaging magazine, she has been a freelance journalist and contributor to Pharmaceutical – Hallie Forcinio Technology since 1993. Hallie Forcinio

WASHINGTON REPORT Published Monthly “The Washington Report provides readers Washington Editor Jill Wechsler has covered government and of Pharmaceutical Technology with regulation for Pharmaceutical Technology for more than a information and insights on important decade, meeting regularly with FDA and USP officials, members of Congress, and industry organization policy proposals and regulatory representatives to report on key developments and the initiatives at the FDA and in Congress emerging trends that shape the industry. that affect drug manufacturing and development.” Jill Wechsler – Jill Wechsler

USP/IPEC COLUMNS

Exclusive insider observation and analysis from two critical industry organizations, the US Pharmacopeia and the International Pharmaceutical Excipients Council, appear regularly throughout the year by special arrangement with Pharmaceutical Technology.

AGENT IN PLACE

A distillation of real-world cautionary tales from the secret files of Control, a senior compliance officer at a US pharmaceutical manufacturer. The column offers object lessons from mishaps caused by clueless operators, oblivious management, awkward lapses of judgment and Murphy's Law in action. But no names, please. years 1977–2007 ANNIVERSARY

PHARMACEUTICAL TECHNOLOGY’S EDITORIAL TEAM

Pharmaceutical Technology Editor in chief Managing editor Kaylynn Chiarello- Douglas McCormick has covered Ebner, MA, joined Pharmaceutical pharma for more than two decades. He Technology in 2003, and is responsible has been corporate director of scientific for editing manuscripts and writing communications for SmithKline news and features. She came to Beecham, editorial director of Nature Pharmaceutical Technology from the Alan Publishing Company, and editor in chief Guttmacher Institute, where she was of Bio/Technology (now Nature editorial coordinator for social science Biotechnology). He received his journals. She holds a master’s degree bachelor's degree in English language from New York University and a and literature from Yale and did bachelor’s degree from Drew University. graduate work in theoretical physics at Stevens Institute of Technology.

Senior editor Maribel Rios, MS, has Senior editor Patricia Van Arnum covers been with Pharmaceutical Technology for active pharmaceutical ingredients, 10 years, during which she has edited intermediates, fine chemicals, and and authored articles, columns, and advances in process R&D for news reports about all aspects of the Pharmaceutical Technology. Patricia was . She previously formerly executive editor of Chemical worked as a research associate and Market Reporter. She has a bachelor’s graduate instructor at the physics degree in chemistry from Rutgers department at Oregon State University. University and holds undergraduate Maribel received undergraduate degrees in economics and political degrees in mathematics and physics science. She is a member of the from Central Washington University and American Chemical Society, the a Master of Science in nuclear physics American Medical Writers Association, from Oregon State University. and previously consulted for DCAT.

Melissa McEvoy Erik Greb Brianne Harrison Art Director Assistant Editor Assistant Editor 1977–2007 years ANNIVERSARY ISSUE COVER STORY

www.pharmtech.com JANUARY Outsourced Services Ad Close: December 1

FEBRUARY Analytical Testing/PAT Peer-Reviewed Research Ad Close: January 2 and Expert Analyses Throughout the year, in print and online, Pharmaceutical Technology publishes first-quality MARCH Lyophilization and Parenteral Dosage Forms peer-reviewed papers, scientific reviews, and expert Ad Close: February 1 analyses that define the leading edge of drug formulation and manufacturing. Pharmaceutical Technology offers solutions in: Continuous Processing APRIL for Solid Dosage Forms • Outsourced and Contract Services INTERPHEX Show Issue • Equipment Ad Close: March 1 • Supplies Equipment Spending Forecast • Software • Validation and Compliance • Method and Technique MAY Process Separation, Filtration, • Standards and Policy and Chromatography Ad Close: April 2 • Training To assist professionals working on: Industry Annual Report: PhRMA • Analytical Testing JUNE and Manufacturing Ranking Data – Methods Development – QC/QA Ad Close: May 1 Monoclonal Antibody Manufacturing – Process Analytical Technology Technology • Formulation 30th Anniversary Issue JULY – Inhaled Dosage Forms Three Decades of Change in Pharmaceutical – Liquid Dosage Forms Science, Technology, Equipment, Regulation – Parenteral Dosage Forms Ad Close: June 1 and Standards – Solid Dosage Forms – Topical and Transdermal • Drug Delivery AUGUST FDA Inspections: Preparing For, Surviving, • Ingredients Ad Close: July 2 and Learning From – Active Ingredients – Excipients

• Information Technology SEPTEMBER • Manufacturing Role of Standards Organizations – Aseptic Processing Ad Close: August 1 in Quality-by-Design – Biotechnology and Macromolecular Processes – Cleaning – Mixing & Blending OCTOBER – Process Automation, Monitoring, and Control: AAPS Show Issue Controlled Release Process Analytical Technology (PAT) Ad Close: September 3 – Process Separation, Filtration, and Chromatography – Tableting NOVEMBER • Packaging and Labeling Information Technology: IT Roundtable – Security, Bar-coding and RFID Ad Close: October 1 • Regulation – 21CFR11 – Validation and Compliance DECEMBER Salary Survey Ad Close: November 1 The Next 30 Years PHARMA INGREDIENTS REPORT ADDITIONAL EDITORIAL BONUS DISTRIBUTION

Outsourced and Contract Services, Manufacturing Equipment & Supplies, Analytical Testing/PAT, IFPAC: Baltimore, MD API Outlook IT/21 CFR Part 11/Automation, Drug Delivery, Process INTERPHEX Puerto Rico: San Juan, PR Validation & Compliance, Regulation, APIs, Automated Select IVT Conference Process Monitoring & Control

Analytical Testing/PAT, Outsourced and Contract Services, Manufacturing Equipment & Supplies, Informex USA: San Francisco, CA API Synthesis IT/21 CFR Part 11/Automation, Process Validation & Pittcon: Chicago, IL Compliance, Regulation, Ingredients, Process Separation, Select IVT Conference Automated Process Monitoring & Control

INTERPHEX Preview, Manufacturing Equipment & Supplies, Outsourced and Contract Services, Packaging & DCAT Week: New York, NY Global API Sourcing Labeling, Process Validation & Compliance, Analytical PDA Annual Meeting: Las Vegas, NV Testing/PAT, IT/21 CFR Part 11/Automation, Drug Delivery, Select IVT Conference Regulation, APIs, Aseptic Processing

Manufacturing Equipment & Supplies, Outsourced and Contract Services, IT/21 CFR Part 11/Automation, Solid ExcipientFest: San Juan, Puerto Rico Specialty Excipients Dosage Forms, Formulation, Excipients, Regulation, INTERPHEX: New York, NY APIs, Process Validation & Compliance, Drug Delivery, Select IVT Conference Analytical Testing/PAT, Packaging & Labeling

Outsourced and Contract Services, Manufacturing Equipment & Supplies, Biotechnology Manufacturing, Peptides and Oligonucleotides BIO: Boston, MA Filtration & Chromatography, Regulation, Process Select IVT Conference Outsourcing Validation & Compliance, Analytical Testing/PAT, IT/21 CFR Part 11/Automation, Drug Delivery

Biotechnology Manufacturing, Drug Delivery, Excipients, Pharm Tech/IVT Annual: Philadelphia, PA Nanotechnologies for Formuation, Outsourced and Contract Services, DIA: Atlanta, GA Manufacturing Equipment & Supplies, Packaging & AAPS Biotech: San Diego, CA Controlled Drug Delivery Labeling, Process Validation & Compliance, Regulation, Controlled Release: Long Beach, CA IT/21 CFR Part 11/Automation The Buyers Guide*

Manufacturing Equipment & Supplies, Outsourced and Contract Services, Drug Delivery, Excipients, Regulation, Chemical Innovations in API Synthesis Select IVT Conference Process Validation & Compliance, Analytical Testing, APIs, IT/21 CFR Part 11/Automation

Manufacturing Equipment & Supplies, Outsourced and American Chemical Society: Boston, MA APIs for Generics Contract Services, Analytical Testing/PAT, Drug Delivery, IT/21 CFR Part 11/Automation, Packaging & Labeling, Select IVT Conference Regulation, Process Validation & Compliance

AAPS Preview, Manufacturing Equipment & Supplies, PDA/FDA Joint Regulatory Conference Process Separation, APIs, Regulation, Packaging & Single-Enantiomer Drugs USP Scientific Meeting: Tampa, FL Labeling, Outsourced and Contract Services, Analytical CPhI/ICSE: Milan, Italy & Chiral Chemistry Testing/PAT, IT/21 CFR Part 11/Automation, Drug Delivery, Select IVT Conference Process Validation & Compliance

Outsourced and Contract Services, Solid Dosage Manufacturing, Drug Delivery, Excipients, Packaging AAPS: San Diego, CA Outsourcing Solid Dosage Manufacturing & Labeling, Process Validation & Compliance, Select IVT Conference IT/21 CFR Part 11/Automation, Analytical Testing/PAT, Regulation, APIs

Information Technology, Manufacturing Equipment & High-Potency Actives & High-Containment Supplies, Outsourced and Contract Services, Software, Chem Show: New York, NY Manufacturing Aseptic Processing, Analytical Testing/PAT, Process Select IVT Conference Validation & Compliance, Drug Delivery

Biotechnology Manufacturing, Outsourced and Select IVT Conference Contract Services, Manufacturing Equipment & Contract Biologics Manufacturing Supplies, Process Validation & Compliance, Corporate Capabilities** Regulation, Analytical Testing/PAT

*The Buyers' Guide will be distributed at all industry shows attended by Pharmaceutical Technology from June 2007-May 2008 **Corporate Capabilities will be distributed at all industry shows attended by Pharmaceutical Technology in 2008 VALUE ADDED OPPORTUNITIES SPECIAL ISSUES

Free 1/3 page INTERPHEX Puerto Rico Exhibitor Profile outlining your company's products and services Free 4-color product/literature release

Primer: Process Monitoring, Free 4-color product/literature release Automation and Control

INTERPHEX Bonus Marketing Package - Advertise in March/April or April/May and receive: Free product/literature release online with hyperlink Free Bonus Buyer Intention Leads from two surveys Free 4-color product/literature release in print edition Free lamination of your ad Free 1/6 page booth invitation at INTERPHEX (booth traffic promotion) Advertise in March, April and May and receive all of the above PLUS: Free duplication of your ad in the INTERPHEX Exhibitor Show Guide distributed to all INTERPHEX attendees (in sponsorship bags, at registration, and at our booth) Free 4-color product/literature release in Show Guide INTERPHEX Show Issue Free online White Paper Free live text link with booth number in Pharmaceutical Technology’s INTERPHEX Show Daily GenerationNext - limited sponsorship opportunities Ask about our online Show Daily sponsorships (see insert) For All May Advertisers: Aseptic Processing Free Ad Performance Study (special offer for full page advertisers) Free 4-color product/literature release

Summer Advertising Package: 2007 Buyers' Guide: Free product/literature release online with hyperlink Free logo, red box listings, bolded listings, 2007 Buyers' Guide (see your sales consultant for details) online listings with hyperlinks Free 4-color product/literature release

Summer Advertising Package: Free product/literature release online with hyperlink (see your sales consultant for details) Free 4-color product/literature release

Free profile page opportunity (special offer for full page advertisers) Free 4-color product/literature release Outsourcing Resources Outsourcing Resources: Free highlighted Provider Services Company Listing

Free online White Paper CPhI/Ingredients Free 4-color product/literature release

AAPS Issue: AAPS Show Issue Free 1/3 page vertical, 4-color profile outlining your company's products and services Free 4-color product/literature release Primer: Pharmaceutical Ask about our online Show Daily sponsorships Chromatography

Free Ad Performance Study (special offer for full page advertisers) IT Supplement Free 4-color product/literature release

Free 4-color product/literature release Corporate Capabilities: Corporate Capabilities Free profile for qualified advertisers Online Bonus Package (see sales consultant for details)

PHARMACEUTICAL TECHNOLOGY EDITORIAL CALENDAR 2007 years 1977–2007 ANNIVERSARY

ANNUAL RESOURCES AND SPECIAL ISSUES

In addition to our monthly issues, Pharmaceutical Technology provides annual resources and special issues showcasing specific areas of interest to readers. The additional supplements and primers we publish every year offer unique topic-focused advertising opportunities.

30th ANNIVERSARY ISSUE CPHI/INGREDIENTS Published in July Published in September Pharmaceutical Technology’s advisory board The CPhI Focus, distributed at the CPhI World exhibition, members and other prominent contributors will covers APIs, intermediates, and formulation with targeted take a look at the past three decades of evolution editorial and special marketing opportunities, including in regulation, equipment, manufacturing bonus distribution at the CPhI World exhibition and the technique, standards, analytical approaches, and AAPS Annual Meeting, plus button advertisements in the other drug-making keystones—with looks at the CPhI Wrap-Up edition of ePT—the Weekly Newsletter of concerns (and advertisements) that appeared in Pharmaceutical Technology. the pages of our first volume.

IT SOLUTIONS/AUTOMATION/21 CFR 11 Published in November INTERPHEX SHOW GUIDE In this specially focused annual issue, Pharmaceutical Published in April Technology updates readers on the rapidly evolving The comprehensive guide to the 2007 technologies of enterprise-wide networking and data INTERPHEX Conference and Exhibition, featuring storage; manufacturing execution and information a showcase of exhibitor/advertiser products, an management software solutions and explains the link exhibitor guide, and conference agenda, with between these technologies to drug development and bonus distribution in INTERPHEX sponsorship manufacturing; quality control and product tracking; and bags, at registration, and our booth. documentation and regulatory compliance operations.

ASEPTIC PROCESSING 2007 CORPORATE CAPABILITIES Published in May Published in December Pharmaceutical Technology’s 2007 Aseptic Showcase your company in Pharmaceutical Technology’s Processing supplement will cover technology 2007 Corporate Capabilities issue. Your advertorial topics and issues of particular importance to this page will include a company description, markets major segment of the pharmaceutical industry. served, technologies, technical services, facilities, Subjects presented will include the latest on major products and two 4-color photographs. Ask your media fill acceptance criteria, barrier/isolation sales consultant about how you could qualify for a technology, sterile filtration, apparel, cleanroom FREE company profile. design, environmental monitoring, process control validation and documentation. THE PRIMER SERIES Published in February: Process Monitoring, Automation and Control BUYERS’ GUIDE Published in October: Pharmaceutical Chromatography Published in June Pharmaceutical Technology’s highly-focused Technology This indispensable resource is distributed to Primers serve to quickly update and educate industry Pharmaceutical Technology’s entire BPA–qualified professionals on the latest, most significant new circulation and to thousands of show attendees developments in critical technology areas. Presented in who save the issue for an entire year. The Buyers’ clear, acronym-explained language, each primer is Guide will be distributed at all industry shows designed to provide both a broad introduction to, as attended from June 2007 through May 2008. well as timely information and discussion of, cutting edge technology in each segment. The Technology OUTSOURCING RESOURCES Primers have become an essential resource, distributed Published in August and frequently referenced throughout pharmaceutical development and manufacturing organizations. In conjunction with Jim Miller of Pharm Source, this special issue of Pharmaceutical Technology delivers exclusive new research every year about the latest trends in the Outsourced Services market, information about future plans to purchase Outsourced Services, and a mix of articles and features on the issues most important to your market. Outsourcing Resources will be distributed at all industry shows attended from September 2007 through August 2008. years 1977–2007years ANNIVERSARY1977–2007 ANNIVERSARY

2007 RATES

2007 BLACK & WHITE RATES - US DOLLARS COLOR CHARGES 1x 3x 6x 12x 18x 24x Standard 935 Full Page 9,065 8,685 8,310 8,110 7,835 7,555 Matched 1,130 2/3 Page 7,575 7,335 7,100 6,850 6,610 6,370 Metallic 1,605 1/2 Page 6,550 6,330 6,115 5,895 5,685 5,470 Four-Color 1,980 1/3 Page 4,700 4,535 4,360 4,185 3,950 3,855 1/4 Page 3,670 3,525 3,380 3,240 3,020 2,955

2007 FOUR COLOR RATES - US DOLLARS SPECIAL POSITIONS 1x 3x 6x 12x 18x 24x Cover 2 815 Full Page 11,045 10,665 10,290 10,090 9,815 9,535 Cover 3 720 2/3 Page 9,555 9,315 9,080 8,830 8,590 8,350 Cover 4 1,165 1/2 Page 8,530 8,310 8,095 7,875 7,665 7,450 Preferred Position 605 1/3 Page 6,680 6,515 6,340 6,165 5,930 5,835 1/4 Page 5,650 5,505 5,360 5,220 5,000 4,935

AD DIMENSIONS PRIMERS

WIDTH DEPTH WIDTH DEPTH Full Page 6 3/4” 9 1/2” Trim Size 5 1/4” 8 3/8” 2/3 Page 4 1/2” 9 1/2” Bleed 5 1/2” 8 5/8” 1/2 Page Island 4 1/2” 7” Live Matter 4 1/4” 7 3/8” 1/2 Page Horizontal 6 3/4” 4 5/8” Spread Size 10 1/2” 8 3/8” 1/2 Page Vertical 3 3/8” 9 1/2” Bleed (Spread) 11” 8 5/8” 1/3 Page Square 4 1/2” 4 5/8” 1/3 Page Vertical 2 1/8” 9 1/2” 1/4 Page 3 3/8” 4 5/8”

PUBLICATION DIMENSIONS

WIDTH DEPTH Trim Size 7 3/4” 10 1/2” Bleed 8” 10 3/4” Live Matter 7” 9 3/4” Spread Size 14 1/2” 9 1/2” Bleed (Spread) 15 3/4” 10 3/4”

NEW! 2007 DIGITAL AD REQUIREMENTS

1. Digital data is required for all ad submissions. Preferred format is PDF/X-1a. Acceptable format is PDF which must contain high resolution images, CMYK image and color mode only (exception: unless additional PMS color is purchased), all fonts embedded, all transparency attributes flattened, maximum total ink density 320%, 1/8” bleed for bleed ads, all trim marks offset minimum of 1/8”, icc profile is “U.S. Web Coated (Swop) v2”, or none should be applied, Publisher shall have no obligation or liability to Advertiser of any kind (including, without limitation, the obligation to offer Advertiser makegoods or any other form of compensation) if an ad is supplied to Publisher by Advertiser in any format other than our preferred or acceptable formats. Non-preferred or non-acceptable formats will be charged a $150 processing fee. All files should be built to exact ad space dimensions purchased. For detailed instructions on preparing and submitting ad files to the correct size, download digital ad specifications from www.AdsAtAdvanstar.com or contact the production manager. 2. Publisher will not supply a faxed or soft proof for Advertiser-supplied files. Advertiser is solely responsible for preflighting and proofing all advertisements prior to submission to Publisher. If Publisher detects an error before going to press, Publisher will make a reasonable effort to contact Advertiser to give Advertiser an opportunity to correct and resubmit Advertiser’s file before publication. 3. Accepted Method of Delivery: The preferred method of delivering ad files to Advanstar is via a web based ad uploader, www.AdsAtAdvanstar.com. Files can also be submitted on CD-R or DVD-R disc format.* 4. Ad Proofs: To insure that Advertiser’s ad is reproduced correctly, a SWOP-certified color proof that has been made from the same file that Advertiser supplies to Publisher must be provided. Publisher cannot provide Advertiser any assurances regarding the accuracy of reproduction of any ad submitted without a SWOP proof. Publisher shall have no obligation or liability to Advertiser of any kind (including, without limitation, the obligation to offer Advertiser makegoods or any other form of compensation) for any ad supplied to Publisher by Advertiser without a SWOP proof. *Send all CD-R or DVD-R files to: Kim Brown, Pharmaceutical Technology, 131 West 1st Street, Duluth, MN 55802-2065 Tel: 218-740-7147 Fax: 218-740-7223 Email: [email protected] years 1977–2007 ANNIVERSARY

STANDARD TERMS AND CONDITIONS FOR ADVERTISING

The following terms and conditions (the “Standard Terms”) shall be incorporated by references into all Insertion Orders submitted to Advanstar Communications Inc. (“Publisher”) by Advertiser or its advertising agency:

A – Invoices are rendered at date of publication.

B – Publisher holds the Advertiser and its advertising agency jointly responsible for paying all duly authorized advertising inserted in or attached to Pharmaceutical Technology. All past due payments may be reinvoiced directly to the Advertiser, who will be held fully responsible for payment.

C – Terms: Invoices are rendered on the publication date of each issue and are due upon receipt. Agency commission will be disallowed on all past due invoices. In the event Advertiser’s account is placed for collection, Advertiser and agency agree to pay Publisher for all reasonable collection costs and/or attorneys’ fees incurred. Advertiser and agency also agree to pay finance charges on the unpaid account balance at the rate of 1-1/2% per month or the maximum permitted by law.

D – Publisher will not be bound by any terms, conditions or provisions appearing on insertion orders or copy instructions with provisions of these Standard Terms, including, without limitation, sequential liability statements from advertising agencies. In the event of any inconsistency between an insertion order and/or copy instructions and these Standard Terms, the Standard Terms shall control.

E – All advertisements are accepted and published by the Publisher on the representation that the agency and/or Advertiser are properly authorized to publish the entire contents and subject matter thereof.

F – Advertiser hereby grants Publisher the right and license to use, reproduce, transmit, and distribute all creative materials supplied by or on behalf of Advertiser, including without limitation, all text, graphics, illustrations and photographs (the “Creative”). Advertiser represents and warrants that: (i) it has all the necessary rights in the Creative; (ii) the Creative does not violate any applicable law or person’s right of publicity, privacy or personality, or may otherwise result in any tort, injury, damage or harm to any person. Advertiser acknowledges the Publisher is relying on the foregoing expenses and losses of any kind (including reasonable attorneys’ fees and costs) incurred based upon a breach of any of the foregoing representations and warranties or in connection with any claim arising from or related to any advertisement supplied by Advertiser or its agents and run by Publisher.

G – Publisher reserves the right to reject any advertising which Publisher feels is not in keeping with the publication’s standards or for any other reason, even if the advertising has been published previously by Publisher.

H – Publisher shall not be liable for any omitted, misplaced, or mispositioned advertisements.

I – All orders are accepted by the Publisher subject to change in rate upon notice from Publisher.

J – Orders may be cancelled within ten (10) business days of the effective date of a change of rates without incurring a shortrate adjustment, provided the Advertiser’s contract rate has been earned as of the date of cancellation.

K – An order may be cancelled without liability up to thirty (30) days prior to the issue’s ad close date. Publisher reserves the right to demand payment for orders cancelled less than thirty (30) days prior to ad close, regardless of the date of ad placement.

L – A 1/4 page ad is the minimum rate holder.

M – Advertiser will be shortrated if, within a 12-month period from the date of the first insertion, Advertiser does not use the amount of space upon which its billings has been based. Advertiser will be rebated if, within a 12-month period from the date of the first insertion, Advertiser has used sufficient additional space to warrant a lower rate than that at which it has been billed.

N – Costs incurred by Publisher for production work on advertisements will be charged to the Advertiser regardless of whether or not the ad runs. Advertiser will be charged for any artwork, separations, halftone, shipping, or typography provided by Publisher.

O – In the event a change of copy is not received by Publisher by the publication’s ad closing date, the copy run in the previous issue of the publication will be inserted.

P – Publisher will hold Advertiser’s materials for a maximum of one year from last issue date. It is the responsibility of the Advertiser to arrange for the disposition of artwork, proofs or digital materials prior to that time, otherwise materials will be destroyed. All requests must be submitted in writing.

Q – Publisher will not be held responsible for consequential costs or other damages due to loss or damage of digital ad materials, art, proofs or transparencies.

R – Reader response inquiries are provided as a service. Publisher disclaims all liability and responsibility for inaccuracies.

S – Under no circumstances shall Publisher be liable for any indirect, incidental, special or consequential damages (including, without limitation, loss of profit or impairment of goodwill) of any Advertiser. Under no circumstances shall Publisher’s direct or indirect liability to any advertising agency or Advertiser exceed the invoiced cost of the advertisement. Notwithstanding the foregoing, Publisher shall have no liability for (i) any failure or delay resulting from conditions beyond Publisher’s control; or (ii) errors in content or omissions in any creative or advertising materials provided by Advertiser.

T – These Standard Terms, together with insertion orders submitted by Advertiser, (i) shall be governed by and construed in accordance with the laws of the State of New York and the United States, without giving effect to principles of conflicts law; (ii) may be amended only by written agreement executed by an authorized representative of each party; and (iii) constitute the complete and entire expression of the agreement between the parties, and shall supersede any and al other agreements regarding the subject matter hereof, whether written or oral, between the parties. Failure by either party to enforce any provision of these Standard Terms shall not be deemed a waiver of future enforcement of that or any other provision. Advertiser may not resell, assign, or transfer any of its rights hereunder.

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