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05 Biomanufacturing Brochure Cxns.Indd Biomanufacturing in North Carolina MANUFACTURERS OF PHARMACEUTICALS AND DIAGNOSTICS CONTRACT MANUFACTURING SERVICE PROVIDERS Biotechnology companies throughout North Carolina are using living cells to COMPANY PRODUCTS LOCATION COMPANY SERVICES LOCATION produce medicines, vaccines, diagnostics, enzymes, amino acids, veterinary Alpharma USPD Pharmaceuticals Lincolnton Broad range of analytical and manufacturing medicines and related products that improve our lives, create jobs and boost our AaiPharma services Wilmington Banner Pharmacaps Pharmaceutical gel caps High Point economy. The making of these biological products is called biomanufacturing or Cardinal Health Analytical services Morrisville bioprocessing. Baxter Healthcare IV Systems Intravenous solutions Marion Bulk chemical synthesis, fill and finish, and DSM Pharmaceuticals aseptic filling services Greenville “North Carolina’s North Carolina is a national leader in this Bespak Drug-delivery devices Apex growing industry. Sixteen companies have Sterile solutions and emulsions for infusion and business climate, low biomanufacturing operations in North BioMerieux Diagnostic kits Durham Hospira nutrition therapy Clayton tax burden and high- Carolina, and at least 30 other companies Carolina Medical Products Ointments, powders, non-injectable solutions Farmville Development and manufacture of topical are engaged in related manufacturing of skill work force make Cytosol Ophthalmics Sterile balanced salt solutions Lenoir Harmony Labs pharmaceuticals and cosmeceuticals Landis this region an attractive pharmaceuticals, diagnostics and medical de- vices. These companies employ an estimated Eisai Pharmatechnology Alzheimer’s drug RTP LabCorp Clinical laboratory services RTP, Burlington place for industries 20,000 people. In addition, tens of thousands Broad range of products in solid, oral dosage Metrics Analytical services Greenville like biotechnology and of North Carolinians work in companies that Eon Labs forms Wilson Pharmacore Organic chemical synthesis High Point provide goods and services in support of bio- biomanufacturing.” GBF Medical Group Diagnostic kits Greensboro manufacturing and related pharmaceutical Pisgah Labs Organic chemical synthesis Pisgah Forest — NORTH CAROLINA GOVERNOR MIKE EASLEY manufacturing. GlaxoSmithKline Drug formulation and packaging Zebulon Industry, government and academia are working to plan and implement a na- Hospira Injectable solutions and drugs Rocky Mount Biomanufacturing jobs pay well. Entry- tionally unique training program through the North Carolina Biomanufacturing level bioprocess technicians typically earn $25,000 to $30,000 and move up Leiner Health Products OTC pharmaceuticals Wilson and Pharmaceutical Training Consortium, a partnership of universities, commu- to $50,000 after five years. The average salary for these positions in North Medtox Diagnostics Drug testing kits Burlington nity colleges, industry and the Biotechnology Center. The program will address Carolina is well above the average pay for other manufacturing jobs, which are training across all the relevant scientific, technical and engineering disciplines at generally declining in number. In 2003, the average annual wage for employees Merck Manufacturing Pharmaceuticals Wilson all levels from Certificate or Associate Degree to Ph.D. The goal is to train 2,000 at biopharmaceutical manufacturing businesses in North Carolina was $70,567, Microban Products Anti-microbial polymeric additives Huntersville to 3,000 students each year. according to the N.C. Employment Security Commission. NittaGelatin USA Gelatin powder for pharmaceuticals and food Fayetteville North Carolina State University in Raleigh will build and equip a $36 million Novo Nordisk Biomanufacturing Training and Education Center (BTEC) scheduled to open A growing industry Pharmaceutical Industries Human insulin formulation and sterile filling Clayton in January 2007. Plans call for a 100,000-square-foot plant that will provide Purdue Pharmaceuticals Pain relief and asthma drugs Wilson hands-on experience in a pilot scale, Good Manufacturing Practices (GMP) en- As more biopharmaceuticals and other products of biotechnology move from vironment similar to an industrial setting. North Carolina Central University in the laboratory to the marketplace, the demand for biomanufacturing capacity is Shionogi Qualicaps Pharmaceutical gel caps Whitsett Durham will receive $19.1 million for the Biomanufacturing Research Institute expected to increase. North Carolina is well positioned to capture a large share TriPath Imaging Burlington and Technology Enterprise (BRITE) to open in January 2007. BRITE will in- of this growing market. The North Carolina (+ TriPath Oncology) Medical reagents (Durham) clude a 65,000-square-foot research laboratory and classroom facility that will Biotechnology Center, in partnership with conduct research, teach and train at all levels in biotechnology and biomanufac- the state Department of Commerce and other Tyco Healthcare Mallinckrodt Acetaminophen Raleigh turing. The North Carolina Community College System will receive $9.4 million organizations, is aggressively promoting the re- for BioNetwork, a network of six centers statewide that will train workers in tention, expansion, and attraction of biomanu- Vintage Pharmaceuticals Pharmaceuticals Charlotte biotechnology, pharmaceutical and life sciences and will channel students into facturing companies. the BTEC and BRITE programs for additional training. In recent years three major biopharmaceuti- Other biomanufacturing plants with established operations in North Carolina Funding is being provided by the non-profit Golden LEAF, a foundation that cal manufacturers — Diosynth RTP, Biogen also have expanded. They include Wyeth Vaccines, which operates one of underwrites economic development activities using half of the state’s tobacco Idec and Merck & Co. — were brought to the world’s largest vaccine facilities in Sanford, and Newco Plasma Services settlement money. Golden LEAF committed $60 million in 2003. The General North Carolina. Diosynth, one of the world’s Biotherapeutics (formerly Bayer), which operates the world’s largest blood largest contract biomanufacturers, carries out fractionation plant in Clayton. Several new biomanufacturing plants also are process development and drug production for coming online in North Carolina. In 2004 Biolex opened a therapeutic protein biopharmaceutical companies. Biogen Idec, biomanufacturing plant in Pittsboro, Embrex dedicated a poultry vaccine plant which operates one of the world’s largest cell- in Laurinburg, AlphaVax announced plans to build a human vaccine plant in culture facilities, manufactures the multiple Durham, and KBI BioPharma, a contract biomanufacturer, opened biopharma- sclerosis drug Avonex® and the psoriasis drug ceutical development services laboratories in Durham. Amevive®. Together, these two companies have created about 1,000 new jobs for North Carolinians, and both continue to expand. Preparing the work force Merck broke ground in October 2004 for a Biomanufacturing plants are complex operations that typically run 24 hours vaccine-manufacturing plant in Durham that is a day, seven days a week, under stringent regulation by the Food and Drug expected to employ at least 200 people when it Administration. Having highly trained technicians who can operate these plants comes online in 2008. efficiently and in compliance with FDA rules is crucial to the growth and success of biomanufacturing companies. Assembly is expected to provide ongoing opera- Building a biomanufacturing community tional funds. Industry is providing millions of dol- The state’s work force training initiative is part of a highly capable infra- lars of in-kind services and equipment. structure that supports the biomanufacturing industry in North Carolina In addition to this training initiative, the and makes the state an attractive location for biomanufacturing com- Biotechnology Center has worked with indus- panies. The biomanufacturing community includes several architecture, try and the North Carolina Community College © construction, engineering, instrumentation System to develop the BioWork course for training entry level bioprocess technicians in bioprocess, “We’re determined that and consulting firms that design, build, pharmaceutical, and chemical manufacturing. This Biomanufacturing North Carolina will upfit and validate bioprocessing plants in 128-hour course, taught by the community colleges, have the world’s best- compliance with FDA requirements. It also covers basic science, cGMP, and manufacturing trained work force for includes a dynamic chapter of the Society technology, giving students the background they need to learn quickly and effectively on the job. A HIGH GROWTH INDUSTRY biomanufacturing.” of Life Science Professionals, a large and active chapter of the International The course is offered to the public and is used by — DR. LESLIE ALEXANDRE, companies for in-house training of new hires and PRESIDENT AND CEO Society of Pharmaceutical Engineers, and FOR NORTH CAROLINA’S NORTH CAROLINA incumbent workers. BIOTECHNOLOGY CENTER. a Bioprocessing and Process Development Focus Group. The Focus Group, sponsored Several community colleges have Associate of ST by the Biotechnology Center, provides a dedicated forum for process Applied Science degree programs in biotechnology; 21 CENTURY ECONOMY development scientists and engineers in the state to discuss issues, bioprocess, chemical, and pharmaceutical
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