DOCSLIB.ORG

Biomanufacturing

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Biomanufacturing World-class training programs BIOMANUFACTURING Top-ranked biotechnology industry IN NORTH CAROLINA Ideal climate for business and life BIOMANUFACTURING A Home for BiomAnufActuring Companies invest hundreds of millions of dollars Novo Nordisk Pharmaceutical in biomanufacturing plants, which require physical Industries and United infrastructure as well as human resources for support. Therapeutics, two companies North Carolina meets those needs with a unique with a long-term North Carolina combination of assets: a skilled workforce, a top-ranked presence, are also expanding their biotech industry, a low cost of doing business and a efforts in the state. Pfizer Poultry high quality of life. Health purchased North Carolina- based Embrex and now operates a poultry The state ranks highly in external surveys as well. vaccine plant near Laurinburg. GlaxoSmithKline, Diosynth and many other multinational companies • Site Selection magazine recognized North Carolina’s operate facilities in North Carolina. Some are among business climate as best in the country for six of the the largest of their type in the world, including Wyeth, last seven years, including 2007. Talecris, Biogen Idec and Novozymes. • Ernst and Young’s annual To add to this impressive roster, “We appreciate the support Beyond Borders report puts the Biotechnology Center is “North Carolina’s business we have received from state the state consistently on growing new companies from climate, low tax burden and and local officials and the the list of top states for university research in plant high-skill workforce make Durham community since biotechnology. science, vaccines and other this region an attractive we located here four years technologies. The Biotechnology place for industries ago. We are proud to be a • In the Milken Institute’s Center is also working with the like biotechnology and part of North Carolina’s cost-of-doing-business Department of Commerce and biomanufacturing.” index, North Carolina’s statewide partners to bring in expanding biopharma —NORth CAROLinA GOveRNOR Mike EASLEY costs are far less than new biomanufacturing operations sector.” other leading states for as well as to expand existing ones. —JOhn WAgneR, MANAgeR OF MERck’S DURHAM PLAnt biotechnology. These companies, plus those offering • Seven scientists with ties to North Carolina have been development, analytical, production honored with Nobel Prizes. and engineering services have created a community that ranks Some of the world’s largest pharmaceutical companies among the best locations for make their products in North Carolina. Novartis biomanufacturing in the world. Vaccines and Diagnostics recognized the state’s advantages and chose Holly Springs over several other locations for a $267 million plant to produce flu vaccine. Merck, looking for a place to produce vaccines for measles, mumps, rubella, chicken pox and shingles, built a $300 million facility in Durham. Both companies have since announced growth plans and additional jobs at these plants. CURRITUCK ALLEGHANY GATES ASHE 85 CASWELL NORTHAMPTON SURRY VANCE PERSON WARREN ROCKINGHAM 77 GRANVILLE 95 PASQUOTANK CAMDEN JoBs for STOKES HERTFORD high-Quality Workforce PERQUIMANS Manufacturing WATAUGA WILKES HALIFAX YADKIN 85 FORSYTH Whitsett DURHAM CHOWAN north carolina locations Boone Greensboro ORANGE Franklinton MITCHELL AVERY 85 Durham BERTIE FRANKLIN CALDWELL 40 Burlington GUILFORD 40 Rocky Mount ALEXANDER ALAMANCE RTP YANCEY DAVIE MADISON NASH EDGECOMBE IREDELL High Point Raleigh WASHINGTON iomanufacturing is a clean manufacturing process that uses living Lenoir DARE herever the location or whatever the product, biomanufacturing WAKE TYRRELL BURKE 40 Pittsboro MCDOWELL DAVIDSON Zebulon WILSON PITT MARTIN cells as miniature factories. It’s how a child’s measles vaccine and the ROWAN RANDOLPH Morrisville plants are complex operations that typically run 24 hours a day, 40 CHATHAM Wilson BUNCOMBE CATAWBA Farmville Bsupplement in an athlete’s protein shake are produced. 40 Landis 95 Wseven days a week, under stringent regulation by the U.S. Food and Drug Holly Springs BEAUFORT Marion 77 Clayton HAYWOOD Lincolnton LEE 40 Greenville HYDE GREENE Administration. Biomanufacturing companies require trained technicians Making these and other products through both biomanu- SWAIN LINCOLN HENDERSON RUTHERFORD 85 CABARRUS HARNETT Sanford JOHNSTON to operate these plants efficiently and in compliance with FDA rules. facturing and traditional processes creates jobs, con- GRAHAM Pisgah Forest MONTGOMERY WAYNE JACKSON POLK CLEVELAND Huntersville STANLY MOORE 26 95 CRAVEN tributes to the state’s economy, and improves lives MECKLENBURG TheNCBioImpact partnership was formed to meet those rigorous GASTON LENOIR CUMBERLAND 40 CHEROKEE MACON Brevard here and around the globe. Approximately 18,000 TRANSYLVANIA Charlotte PAMLICO demands. North Carolina’s universities and community col- HOKE CLAY SAMPSON JONES North Carolina residents are employed by a broad RICHMOND leges collaborated with industry, the North Carolina UNION ANSON Fayetteville range of companies including biomanufacturers, Pharmaceutical Service Providers DUPLIN Biosciences Organization and the Biotechnology SCOTLAND ONSLOW manufacturers of traditional pharmaceuticals and Biomanufacturers ROBESON CARTERET Center to produce and deliver workforce-train- diagnostics, as well as pharmaceutical service pro- ing programs across the state. The Manufacturers of Traditional Pharmaceuticals BLADEN Golden LEAF Maxton 40 viders, which offer analytical and production services. and Diagnostics Foundation has committed nearly $70 million of (tables below, right) PENDER North Carolina’s tobacco-settlement money to sup- port this initiative. Industry partners have allocated Although they won’t replace all of the lost furniture and textile manu- Manufacturers of traditional COLUMBUS NEW HANOVER millions of dollars of in-kind services and equipment. facturing jobs, these companies offer higher-paying jobs than traditional PharMaceuticals and diagnostics Wilmington And the state’s General Assembly supplies ongoing fund- manufacturing: BRUNSWICK ing for operations. COMPANY LOCATION PRODUCTS Southport • Entry-level technicians typically earn $25,000 to $30,000 with basic Ointments, creams, nasal sprays and other This broad partnership has yielded a three-pronged approach: training and often earn more than $50,000 after five years of experience. Actavis U.S. Lincolnton products BioManufacturers • The Golden LEAF Biomanufacturing Training and Education • The average salary for all jobs in the pharmaceutical manufactur- Banner High Point Pharmaceutical gel caps Center on Centennial Campus at North Carolina State University. ing industry—including those requiring more education—exceeds BASF Corp. Wilmington Vitamins and nutrition products COMPANY LOCATION PRODUCTS BTEC is the world’s largest hands-on training location dedicated to $82,000 in the state. Ajinomoto USA Raleigh Amino Acids Baxter Healthcare Marion Intravenous solutions learning the ins and outs of biomanufacturing. (www.btec.ncsu.edu) Also, biomanufacturing plants are located around the state, which distrib- BD Diagnostics, TriPath Burlington Cervical cancer screening kits Alphavax Durham Vaccines • TheBiomanufacturing Research Institute and Technology utes these jobs throughout North Carolina. bioMerieux Durham Diagnostic kits Archer Daniels Midland Southport Citric acid Enterprise at North Carolina Central University. BRITE is dedicated Carolina Medical Products Farmville Ointments, powders, non-injectable solutions Argos Therapeutics Durham Vaccines to research and higher-level training in the life sciences, and to also PharMaceutical service Providers Covidien Mallinckrodt Raleigh Acetaminophen Multiple sclerosis, psoriasis and Crohn’s uncovering ways to improve biomanufacturing processes. Biogen Idec RTP disease treatments Eisai RTP Alzheimer’s drug (brite.nccu.edu) COMPANY LOCATION PRODUCTS Biolex Therapeutics Pittsboro Therapeutic proteins GBF Medical Group Greensboro Diagnostic kits • is a collection of more than 20 community colleges aaiPharma Wilmington Analytical and manufacturing services Development, manufacture and packaging NCBioNetwork across the state connected by their biotechnology program offerings. Catalent Pharma Solutions Morrisville Analytical services GlaxoSmithKline Zebulon Drug formulation and packaging Catalent Pharma Solutions Raleigh services for bio-based products The effort includes seven specialized centers that meet specific needs Bulk chemical synthesis, fill and finish, aseptic Hospira Rocky Mount Injectable solutions and drugs CellzDirect RTP Specialized cells and their products. of life-science industry sectors. (www.ncbionetwork.org) DSM Pharmaceuticals Greenville filling services MEDTOX Diagnostics Burlington Drug testing kits Diosynth Biotechnology RTP Contract biopharmaceutical manufacturing Gorbec Pharmaceutical Merck & Company Wilson Pharmaceuticals Greer Laboratories Lenoir Allergenic extracts, vaccines “North Carolina From certificate to Ph.D., Services Durham Contract analysis and production services NCBioImpact trains and helps Microban International Huntersville Antimicrobial polymeric additives KBI BioPharma Durham Contract biopharmaceutical manufacturing Development and manufacture of topical understands the bioscience retain job-ready employees at all Nitta Gelatin USA Fayetteville Gelatin powder for pharmaceuticals and food Harmony Labs Landis pharmaceuticals and cosmeceuticals Merck & Company Durham
Load more

Recommended publications
  • Biomanufacturing Technology Roadmap
    ©BioPhorum Operations Group Ltd SUPPLY PARTNERSHIP MANAGEMENT BIOMANUFACTURING TECHNOLOGY ROADMAP SUPPLY PARTNERSHIP MANAGEMENT BPOG Technology Roadmap 1 ©BioPhorum Operations Group Ltd SUPPLY PARTNERSHIP MANAGEMENT Acknowledgments The following member company participants are acknowledged for their efforts and contributions in the production of this roadmap document. (* indicates non-member contributor) AstraZeneca Merck & Co. Inc., Kenilworth, NJ, USA Merck KGaA, Darmstadt, Germany Mike Kinley Adam Randall Kendall Nichols Bayer Pfizer Asahi Kasei Bioprocess Edgar Sur Jennifer Johns Kimo Sanderson Biogen Roche Thermo Fisher Scientific Dave Kolwyck Freia Funke Steve Gorfien Rhea Mahabir GSK Shire Iris Welch Alan Glazer BioPhorum Operations Group Mike McSweeney Alfred Keusch Bob Brooks Bela Green Janssen Avantor* Chris Calabretta Dave Lescinski* BPOG Technology Roadmap 2 ©BioPhorum Operations Group Ltd SUPPLY PARTNERSHIP MANAGEMENT Contents 1 Summary ..............................................................................................................................................................................................................5 2 Introduction .........................................................................................................................................................................................................6 2.1 Vision ....................................................................................................................................................................................................................................6
    [Show full text]
  • Rapid Vaccine Development & Biomanufacturing Using a Scalable
    Rapid Vaccine Development & Biomanufacturing Using a Scalable, Non-viral Delivery Platform for Cell Engineering. James Brady, Weili Wang, Rama Shivakumar, Pachai Natarajan, Krista Steger, and Madhusudan Peshwa. MaxCyte, Gaithersburg, MD, USA. Abstract Researchers have looked to recombinant technologies to develop innovative types of vaccines and new cell culture-based means of production that offer shorter lead times and greater production flexibility while High Level Cell Viability and Transfection maintaining vaccine safety. Transient transfection offers a means of rapidly producing an array of proteins, Efficiencies including antibodies, vaccines, viral vectors, and virus-like particles (VLPs). Although a variety of transient transfection methods are available, most do not meet the requirements of scalability, consistency, and cell Figure 1. High Efficiency Transfection of Cell Types type flexibility for use in vaccine development and manufacturing. MaxCyte’s electroporation-based delivery Commonly Used for Protein and Vaccine Production. platform reproducibly transfects a broad range of biorelevant adherent and suspension cell types with high Various cells were transfected with 2 µg/1E6 cells of pGFP cell viabilities & transfection efficiencies using single-use processing assemblies for cGMP, “plug-and-play” DNA using the appropriate MaxCyte STX protocol. Cells production of recombinant proteins and vaccines. In this poster we present data for large-scale production were examined for GFP expression using fluorescence microscopy 24 hrs post electroporation (EP). of antibodies, recombinant antigens, VLPs, and lentiviral vectors using the MaxCyte STX® Scalable Transfection System. Data are presented for high-efficiency transfection of cells commonly used in protein production including CHO, HEK293, and insect cells--without the use of baculovirus--with a timeline of just a few days from plasmid to gram quantities of protein.
    [Show full text]
  • Bioprocessing Asia 2018 Programme and Abstract Book
    BPA BioProcessing Asia BioProcessing Asia 2018 Programme and Abstract Book Third International Conference LANGKAWI, MALAYSIA, 12–15 NOVEMBER 2018 Contents General Information 4 The BioProcessing Asia Conference Series 7 Scientific Advisory Committee 8 Sponsors 10 Programme 18 Poster list 24 Abstracts 26 Session 1 27 Session 2 30 Session 3 33 Session 4 37 Session 5 41 Session 6 45 Poster Session 7 49 Welcome to the Third International BioProcessing Asia Conference at the Langkawi International Convention Centre, Langkawi, Malaysia It is a great pleasure to welcome you to the third meeting in the BioProcessing Asia Conference Series. This Conference continues the trend set by the two previous BPA conferences in 2014 and 2016 in exploring themes and topics focused on the contribution of bioprocessing towards the development and manufacture of affordable biopharmaceutical products in Asia. Of particular importance at this conference is the contribution made by our Scientific Advisory Committee on the identification of specific current trends in the field. This input has led to the selection of six Oral Sessions that cover important aspects of bioprocessing ranging from disease treatments, innovations in technology, vaccine design and development, the changing environment of plasma products, disruptive manufacturing strategies and the evolving regulatory environment in Asia. These topics are further developed and explored in the Poster Session where, as in the past, more detailed discussions and the exploration of ideas without the usual constraints of time can be pursued. We are fortunate to have attracted several outstanding Keynote and Focus lecturers to the meeting including Dr Ashok Kumar, President of IPCA Ltd’s R&D Centre in Mumbai and Dr Subash Kapre, Director Emeritus at the Serum Institute of India and from Inventprise, USA, who, together with the distinguished Session Chairs will set the tone and lead the discussions on salient areas of bioprocessing.
    [Show full text]
  • Scale and High-Quality Human T Cells Production Jianfa Ou1, Yingnan Si1, Yawen Tang1, Grace E
    Ou et al. Journal of Biological Engineering (2019) 13:34 https://doi.org/10.1186/s13036-019-0167-2 RESEARCH Open Access Novel biomanufacturing platform for large- scale and high-quality human T cells production Jianfa Ou1, Yingnan Si1, Yawen Tang1, Grace E. Salzer1, Yun Lu1, Seulhee Kim1, Hongwei Qin2, Lufang Zhou3 and Xiaoguang Liu1* Abstract The adoptive transfer of human T cells or genetically-engineered T cells with cancer-targeting receptors has shown tremendous promise for eradicating tumors in clinical trials. The objective of this study was to develop a novel T cell biomanufacturing platform using stirred-tank bioreactor for large-scale and high-quality cellular production. First, various factors, such as bioreactor parameters, media, supplements, stimulation, seed age, and donors, were investigated. A serum-free fed-batch bioproduction process was developed to achieve 1000-fold expansion within 8 days after first stimulation and another 500-fold expansion with second stimulation. Second, this biomanufacturing process was successfully scaled up in bioreactor with dilution factor of 10, and the robustness and reproducibility of the process was confirmed by the inclusion of different donors’ T cells of various qualities. Finally, T cell quality was monitored using 12 surface markers and 3 intracellular cytokines as the critical quality assessment criteria in early, middle and late stages of cell production. In this study, a new biomanufacturing platform was created to produce reliable, reproducible, high-quality, and large-quantity (i.e. > 5 billion) human T cells in stirred-tank bioreactor. This platform is compatible with the production systems of monoclonal antibodies, vaccines, and other therapeutic cells, which provides not only the proof-of-concept but also the ready-to-use new approach of T cell expansion for clinical immune therapy.
    [Show full text]
  • So, What Is Biomanufacturing?
    Bioscience Industry Fellowship Project 2014 Presentations S Table of Contents Example of Course Development for STEM Slides 3-14 Community College Instructors Heather King; Igor Kreydin What does “Boot Camp” mean? Slides 15-61 Julie Ellis; Ezekiel Barnes Recruitment Plan for Biosciences Slides 62-66 Scott Gevart; Daymond Lindell Bioscience Awareness: Using what we know to Slides 67-93 build for tomorrow’s sustainability Savitha Pinnepalli; Jude Okoyeh BIOSCIENCES INDUSTRY FELLOWSHIP PROGRAM JUNE 2-27, 2014 Example of Course Development for STEM Community College Instructors (Based on BIFP Experience) Heather King Igor Kreydin Developmental Math Instructor STEAM Instructor Forsyth Technical Community College, NC Roxbury Community College, MA [email protected] [email protected] Modern Industry 2012 Educational Profile for Biotechnology Employees in NC High School 4% High School plus Certificate 10% 17% Associates in Science or 13% Associates in Applied Science Bachelor of Arts or Science 43% 13% Master of Arts or Science Doctorate NCGE-North Carolina in the Global Economy Project, http://www.ncglobaleconomy.com/NC_GlobalEconomy/biotechnology/overview.shtml In every math class you will hear … Why do I need to know this? When will I ever use this? In every science class you will hear … Did I learn how to do this in my math class? Don’t Let Your Students Get Stuck Here. Make Math Relevant! Basic Mathematical Concepts Equations Proportions Ratios of Lines Percents Exponents Basic Biotechnology Solving Equations Statistics Applications Graphs Fractions Scientific Formulas Conversions Notation Expressions, Linear Equations & Inequalities Dilutions of Solutions Forsyth Technical Community College Suppose you have a stock TGS electrophoresis buffer solution that is used in a protein profiler investigation of fish.
    [Show full text]
  • Careers in Biomanufacturing
    mapping your future: EXPLORING CAREERS IN BIOMANUFACTURING An Educational Module for Middle School and High School Teachers and Students Prepared by the North Carolina Association for Biomedical Research under contract with the North Carolina Biotechnology Center July 2006 mapping your future: EXPLORING CAREERS IN BIOMANUFACTURING This educational module was prepared by: The North Carolina Association for Biomedical Research (NCABR) P.O. Box 19469 Raleigh, NC 27619-9469 919-785-1304 http://www.ncabr.org Contact NCABR to obtain additional copies. © 2006 North Carolina Association for Biomedical Research. All rights reserved. mapping your future: EXPLORING CAREERS IN BIOMANUFACTURING ACKNOWLEDGEMENTS INTRODUCTION UNIT I: BIOTECHNOLOGY AND ITS APPLICATIONS A. What is Biotechnology? . 4 B. Biotechnology Timeline. 5 Student Activity: Biotech Timeline . 7 C. Practical Applications of Biotechnology . 12 Student Activity: Create a Logo. 18 Student Activity: Make a Yeast Incubator . 20 Student Activity: DNA Extraction From Yeast . 24 UNIT II: FROM LAB TO MARKET: DRUG DISCOVERY AND MANUFACTURING A. How a New Drug Gets to Market — An Overview . 28 B. Clinical Trials — A Closer Look . 29 C. The Pharmaceutical and Biopharmaceutical Industries — Regulated for Safety and Quality. 31 Student Activity: New Drug Development . 33 D. Producing a Pharmaceutical or Biopharmaceutical — The Manufacturing Process. 38 E. What Quality Means and Why It Matters . 39 F. Standard Operating Procedure (SOP) and Regulations . 41 Student Activity: Say What You Do and Do What You Say. 42 UNIT III: BIOMANUFACTURING CAREER OPPORTUNITIES A. Biotechnology Generates Opportunities . 48 B. Seizing the Opportunity . 49 C. On the Job — Typical Biomanufacturing Job Positions . 50 Student Activity: A Day in the Life of Six Biomanufacturing Employees .
    [Show full text]
  • A Breakthrough High-Performance Viral Vaccines Biomanufacturing Platform to Countermeasure Epidemic Threats
    A breakthrough high-performance viral vaccines biomanufacturing platform to countermeasure epidemic threats Webinar Dr. Tania Pereira Chilima, deputy CTO Brussels, May 2020 ©2020 Univercells Technologies. All Rights reserved The next evolution of biomanufacturing Univercells Technologies designs and delivers state-of-the-art high- performance, scalable bioproduction technologies for viral products Univercells Technologies genesis 2013 2020 Mission Make biologics affordable Design and deliver the next evolution and available to all! of biomanufacturing History > Created in 2013 in Belgium > Univercells subsidiary created in 2020 > Capitalizing on unmatched bioprocessing > Revolutionizing bioprocess by commercializing and engineering expertise next generation viral manufacturing technologies Focus > Offering technologies, services and > Intensification of high-performance operations & turnkey solutions to alleviate the chaining of unit steps into an integrated process industry’s current shortfall in supply of cell > Key assets: NevoLine™ platform & scale-X™ and gene therapies, vaccines and bioreactor biotherapeutics Source: Univercells Technologies ©2020 Univercells Technologies. All Rights reserved 2 Univercells technologies capitalizes on a strong team of experts and a global footprint for equipment dissemination and client support Capabilities Engineers and and expertise 60+ process specialists Employees R&D > Assembly, manufacturing > Validation (FAT) Engineering services > Supply and Logistics for installation, training and maintenance
    [Show full text]
  • Biomanufacturing: Time for Change?
    Pharmaceutical Editorial Pharm. Bioprocess. (2013) 1(1), 7–9 Biomanufacturing: time for change? “The biomanufacturing industry needs to innovate to compete with» these new market entrants. It needs to seize opportunities when they arise and take risks on novel technologies that may disrupt the market as well as moving it forwards in small increments.”« The biomanufacturing industry is heading for stormy weather. This may seem a rather blunt way to decry the lack of innovation in an industry that is forever caught between the need Uwe Gottschalk to standardize and the need to create value from new ideas, but there is now an urgent need Sartorius-Stedim Biotech, Göttingen, to innovate in the industry as a whole to face the new market challenges, which are only just Germany over the horizon. Tel.: +49 551 308 2016 Biomanufacturing was a new and unexplored territory 30 years ago. The first pioneers Fax: +49 551 308 3705 E-mail: uwe.gottschalk@ developed technologies that were suitable for a virgin market, focusing on product approvals sartorius-stedim.com rather than process efficiency and cost because their products were unique. Today’s industry is so different that those pioneers could not have imagined how the environment would change. There is more competition, with hundreds of products in development, and there is also a rising wave of off-patent biopharmaceuticals that are attracting a new kind of player in the market, concerned only with the production of generics. Albert Einstein is renowned for his creative and unorthodox approach to solving problems, but he also had rather a lot to say about innovation.
    [Show full text]
  • Biomanufacturing 45-MINUTE ONLINE CLASS | LEVEL 2 | SUGGESTED PREREQUISITES: the BIOLOGY of BIOTECH, INTRODUCTION to GENETIC ENGINEERING
    Biomanufacturing 45-MINUTE ONLINE CLASS | LEVEL 2 | SUGGESTED PREREQUISITES: THE BIOLOGY OF BIOTECH, INTRODUCTION TO GENETIC ENGINEERING OVERVIEW Biomanufacturing introduces the intricacies and difficulties involved in manufacturing biologics. Biologics are produced in living cells, unlike small molecule drugs that are synthesized in glasswear. To understand the biopharma industry, you need know how biologic medicines are produced. Biomanufacturing is for everyone in the biopharma industry, especially for those new to drug production, drug development or product launch. Five Takeaways: 1. List the types of products produced in biomanufacturing. 2. Explain how cell lines are developed. 3. Cite the need for cell banks and the process of cell bank production. 4. Describe in detail the steps of a biomanufacturing campaign. 5. Explain the testing protocols that ensure product quality. AGENDA • Cell and Cell Banks explains cell line development and the process of cell bank production. • The Manufacturing Process discusses in detail the steps used to make biologics, specifically bulk upstream and bulk downstream processing. • Harvesting and Purification highlights the nuances involved in harvesting and purifying a therapeutic protein from cell culture and explains the testing protocols that ensure drug product quality. • Emerging Technologies explores some of the new technologies that companies are using to reduce costs and increase yield of the drug product. These include continuous bioprocessing, continuous chromatography, and single-use systems. WHAT PEOPLE ARE SAYING “I was eager to take the (online) biomanufacturing class because the subject matter is interesting to me. Once I took the first one, it made me want to take more.” -Director of External Innovation.
    [Show full text]
  • NCBIOIMPACT Flier
    Training Workers, Recruiting Companies, Strengthening the North Carolina Economy NCBioImpact To expand pharmaceutical training efforts, the North Carolina Pharmaceutical Services Network was started in 2017. It received NCBioImpact is a public/private partnership that brings a grant from the Golden LEAF Foundation and funding from Pitt together resources from the life sciences industry, the County Development Commission, Pitt County Committee of 100 North Carolina Biosciences Organization, and the and NCBiotech. North Carolina Biotechnology Center with the University of North Carolina System and the North Carolina Community An Impressive Track Record College System. This collaboration has produced an internationally recognized training program. NCBioImpact’s focused approach to worker training helped ignite the rapid growth of North Carolina’s biotech manufacturing Education partners—each with a unique mission but a cluster. North Carolina consistently ranks in the top tier of life common goal—provide students and current employees sciences clusters. Beyond biomanufacturing, the life sciences with hands-on training and experience with equipment sector in North Carolina creates: and processes used by industry. • $84 billion in annual economic activity • BioNetwork (N.C. Community Colleges) • 240,000 jobs • Golden LEAF Biomanufacturing Research Institute and • $2.3 billion in state and local government revenues Technology Enterprise (BRITE at N.C. Central University) • Golden LEAF Biomanufacturing Training and Education Center (BTEC at North Carolina State University) AVERAGE SALARIES • North Carolina Pharmaceutical Service Network (NCPSN at East Carolina University and at Pitt Community College) $97K+ $55K+ How NCBioImpact is Funded for a job in early career salary N.C. biotech sector in biomanufacturing NCBioImpact was founded in 2002, after leaders recognized a need to train workers to help the state’s biomanufacturing industry continue to grow.
    [Show full text]
  • Biomanufacturing: a State of the Technology Review
    SANDIA REPORT SAND2003-3302 Unlimited Release Printed September 2003 Biomanufacturing: A State of the Technology Review Sarah Morgan, Silverio Colon, John A. Emerson, Ramona L. Myers, and Judith A. Ruffner Prepared by Sandia National Laboratories Albuquerque, New Mexico 87185 and Livermore, California 94550 Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy’s National Nuclear Security Administration under Contract DE-AC04-94AL85000. Approved for public release; further dissemination unlimited. Issued by Sandia National Laboratories, operated for the United States Department of Energy by Sandia Corporation. NOTICE: This report was prepared as an account of work sponsored by an agency of the United States Government. Neither the United States Government, nor any agency thereof, nor any of their employees, nor any of their contractors, subcontractors, or their employees, make any warranty, express or implied, or assume any legal liability or responsibility for the accuracy, completeness, or usefulness of any information, apparatus, product, or process disclosed, or represent that its use would not infringe privately owned rights. Reference herein to any specific commercial product, process, or service by trade name, trademark, manufacturer, or otherwise, does not necessarily constitute or imply its endorsement, recommendation, or favoring by the United States Government, any agency thereof, or any of their contractors or subcontractors. The views and opinions expressed herein do not necessarily state or reflect those of the United States Government, any agency thereof, or any of their contractors. Printed in the United States of America. This report has been reproduced directly from the best available copy.
    [Show full text]
  • Integrating U.S. Biomanufacturing Infrastructure.Indd
    COMMENTARY Integrating United States Biomanufacturing Across Vaccines and Therapeutics Krishanu Saha, PhD, University of Wisconsin-Madison; and Krishnendu Roy, PhD, Georgia Institute of Technology April 19, 2021 In 2021, as the majority of the world’s population ea- access is critically needed. In addition to supply chain gerly waits to receive safe and eff ective COVID-19 vac- and logistics, advances in the science, technology, and cines, factories worldwide are producing bits of the infrastructure for biomanufacturing (a scientifi c fi eld fo- vaccine components—mRNA, lipids, proteins, key re- cused on making various biological products effi cient- agents, and attenuated viruses—and then assembling ly, in high-quality, and at scale [1,2,3,4]), is necessary them into complete, ready-to-inject vaccines. This pro- to improve the supply, consistency, quality, cost, and cess has now gained signifi cant attention, not just for access of products to meet the current and future de- the speed at which the scientifi c community innovated mand worldwide. and developed multiple and hugely eff ective vaccines In light of these similarities, preparation for the for COVID-19, but also because of the massive short- world’s post-pandemic future should consider the falls in vaccine production, supply, and equitable dis- growth of the vaccine and advanced therapies fi elds tribution across the world. Also under scrutiny is the together. Recent scale-up and modernization of vac- level of government intervention that has been neces- cine biomanufacturing will have spillover eff ects for sary to accelerate vaccine production and distribution. CGTs, while much-needed future innovations and in- What is less recognized is that such inadequacies in vestments in CGT and ETO manufacturing will provide biomanufacturing and supply chain robustness are not surge and advanced manufacturing capacity for vac- just limited to vaccines.
    [Show full text]