IN NORTH CAROLINA NORTH IN BIOMANUFACTURING Top-ranked biotechnologyindustry Ideal climate forlife and business World-class training programs World-classtraining BIOMANUFACTURING A Home for Biomanufacturing

Companies invest hundreds of millions of dollars Novo Nordisk Pharmaceutical in biomanufacturing plants, which require physical Industries and United infrastructure as well as human resources for support. Therapeutics, two companies North Carolina meets those needs with a unique with a long-term North Carolina combination of assets: a skilled workforce, a top-ranked presence, are also expanding their biotech industry, a low cost of doing business and a efforts in the state. Pfizer Poultry high quality of life. Health purchased North Carolina- based Embrex and now operates a poultry The state ranks highly in external surveys as well. vaccine plant near Laurinburg. GlaxoSmithKline, Diosynth and many other multinational companies • Site Selection magazine recognized North Carolina’s operate facilities in North Carolina. Some are among business climate as best in the country for six of the the largest of their type in the world, including Wyeth, last seven years, including 2007. Talecris, Biogen Idec and Novozymes.

• Ernst and Young’s annual To add to this impressive roster, “We appreciate the support Beyond Borders report puts the Biotechnology Center is “North Carolina’s business we have received from state the state consistently on growing new companies from climate, low tax burden and and local officials and the the list of top states for university research in plant high-skill workforce make Durham community since biotechnology. science, vaccines and other this region an attractive we located here four years technologies. The Biotechnology place for industries ago. We are proud to be a • In the Milken Institute’s Center is also working with the like biotechnology and part of North Carolina’s cost-of-doing-business Department of Commerce and biomanufacturing.” index, North Carolina’s statewide partners to bring in expanding biopharma —North Carolina Governor Mike Easley costs are far less than new biomanufacturing operations sector.” other leading states for as well as to expand existing ones. —John Wagner, manager of Merck’s Durham plant biotechnology. These companies, plus those offering • Seven scientists with ties to North Carolina have been development, analytical, production honored with Nobel Prizes. and engineering services have created a community that ranks Some of the world’s largest pharmaceutical companies among the best locations for make their products in North Carolina. Novartis biomanufacturing in the world. Vaccines and Diagnostics recognized the state’s advantages and chose Holly Springs over several other locations for a $267 million plant to produce flu vaccine. Merck, looking for a place to produce vaccines for measles, mumps, rubella, chicken pox and shingles, built a $300 million facility in Durham. Both companies have since announced growth plans and additional jobs at these plants. CURRITUCK ALLEGHANY GATES ASHE 85 CASWELL NORTHAMPTON SURRY VANCE PERSON WARREN ROCKINGHAM 77 GRANVILLE 95 PASQUOTANK CAMDEN Jobs for STOKES HERTFORD High-Quality Workforce PERQUIMANS manufacturing WATAUGA WILKES HALIFAX YADKIN 85 FORSYTH Whitsett DURHAM CHOWAN North Carolina locations Boone Greensboro ORANGE Franklinton MITCHELL AVERY 85 Durham BERTIE FRANKLIN CALDWELL 40 Burlington GUILFORD 40 Rocky Mount ALEXANDER ALAMANCE RTP YANCEY DAVIE MADISON NASH EDGECOMBE IREDELL High Point Raleigh WASHINGTON iomanufacturing is a clean manufacturing process that uses living Lenoir DARE herever the location or whatever the product, biomanufacturing WAKE TYRRELL BURKE 40 Pittsboro MCDOWELL DAVIDSON Zebulon WILSON PITT MARTIN cells as miniature factories. It’s how a child’s measles vaccine and the ROWAN RANDOLPH Morrisville plants are complex operations that typically run 24 hours a day, 40 CHATHAM Wilson BUNCOMBE CATAWBA Farmville Bsupplement in an athlete’s protein shake are produced. 40 Landis 95 Wseven days a week, under stringent regulation by the U.S. Food and Drug Holly Springs BEAUFORT Marion 77 Clayton HAYWOOD Lincolnton LEE 40 Greenville HYDE GREENE Administration. Biomanufacturing companies require trained technicians Making these and other products through both biomanu- SWAIN LINCOLN HENDERSON RUTHERFORD 85 CABARRUS HARNETT Sanford JOHNSTON to operate these plants efficiently and in compliance with FDA rules. facturing and traditional processes creates jobs, con- GRAHAM Pisgah Forest MONTGOMERY WAYNE JACKSON POLK CLEVELAND Huntersville STANLY MOORE 26 95 CRAVEN tributes to the state’s economy, and improves lives MECKLENBURG TheNCBioImpact partnership was formed to meet those rigorous GASTON LENOIR CUMBERLAND 40 CHEROKEE MACON Brevard here and around the globe. Approximately 18,000 TRANSYLVANIA Charlotte PAMLICO demands. North Carolina’s universities and community col- HOKE CLAY SAMPSON JONES North Carolina residents are employed by a broad RICHMOND leges collaborated with industry, the North Carolina UNION ANSON Fayetteville range of companies including biomanufacturers, Pharmaceutical Service Providers DUPLIN Biosciences Organization and the Biotechnology SCOTLAND ONSLOW manufacturers of traditional pharmaceuticals and Biomanufacturers ROBESON CARTERET Center to produce and deliver workforce-train- diagnostics, as well as pharmaceutical service pro- ing programs across the state. The Manufacturers of Traditional Pharmaceuticals BLADEN Golden LEAF Maxton 40 viders, which offer analytical and production services. and Diagnostics Foundation has committed nearly $70 million of (tables below, right) PENDER North Carolina’s tobacco-settlement money to sup- port this initiative. Industry partners have allocated Although they won’t replace all of the lost furniture and textile manu- Manufacturers of Traditional COLUMBUS NEW HANOVER millions of dollars of in-kind services and equipment. facturing jobs, these companies offer higher-paying jobs than traditional Pharmaceuticals and Diagnostics Wilmington And the state’s General Assembly supplies ongoing fund- manufacturing: BRUNSWICK ing for operations. company location products Southport • Entry-level technicians typically earn $25,000 to $30,000 with basic Ointments, creams, nasal sprays and other This broad partnership has yielded a three-pronged approach: training and often earn more than $50,000 after five years of experience. Actavis U.S. Lincolnton products Biomanufacturers • The Golden LEAF Biomanufacturing Training and Education • The average salary for all jobs in the pharmaceutical manufactur- Banner High Point Pharmaceutical gel caps Center on Centennial Campus at North Carolina State University. ing industry—including those requiring more education—exceeds BASF Corp. Wilmington Vitamins and nutrition products company location products BTEC is the world’s largest hands-on training location dedicated to $82,000 in the state. Ajinomoto USA Raleigh Amino Acids Baxter Healthcare Marion Intravenous solutions learning the ins and outs of biomanufacturing. (www.btec.ncsu.edu) Also, biomanufacturing plants are located around the state, which distrib- BD Diagnostics, TriPath Burlington Cervical cancer screening kits Alphavax Durham Vaccines • TheBiomanufacturing Research Institute and Technology utes these jobs throughout North Carolina. bioMerieux Durham Diagnostic kits Archer Daniels Midland Southport Citric acid Enterprise at North Carolina Central University. BRITE is dedicated Carolina Medical Products Farmville Ointments, powders, non-injectable solutions Argos Therapeutics Durham Vaccines to research and higher-level training in the life sciences, and to also Pharmaceutical Service Providers Covidien Mallinckrodt Raleigh Acetaminophen Multiple sclerosis, psoriasis and Crohn’s uncovering ways to improve biomanufacturing processes. Biogen Idec RTP disease treatments Eisai RTP Alzheimer’s drug (brite.nccu.edu) company location products Biolex Therapeutics Pittsboro Therapeutic proteins GBF Medical Group Greensboro Diagnostic kits • is a collection of more than 20 community colleges aaiPharma Wilmington Analytical and manufacturing services Development, manufacture and packaging NCBioNetwork across the state connected by their biotechnology program offerings. Catalent Pharma Solutions Morrisville Analytical services GlaxoSmithKline Zebulon Drug formulation and packaging Catalent Pharma Solutions Raleigh services for bio-based products The effort includes seven specialized centers that meet specific needs Bulk chemical synthesis, fill and finish, aseptic Hospira Rocky Mount Injectable solutions and drugs CellzDirect RTP Specialized cells and their products. of life-science industry sectors. (www.ncbionetwork.org) DSM Pharmaceuticals Greenville filling services MEDTOX Diagnostics Burlington Drug testing kits Diosynth Biotechnology RTP Contract biopharmaceutical manufacturing Gorbec Pharmaceutical Merck & Company Wilson Pharmaceuticals Greer Laboratories Lenoir Allergenic extracts, vaccines “North Carolina From certificate to Ph.D., Services Durham Contract analysis and production services NCBioImpact trains and helps Microban International Huntersville Antimicrobial polymeric additives KBI BioPharma Durham Contract biopharmaceutical manufacturing Development and manufacture of topical understands the bioscience retain job-ready employees at all Nitta Gelatin USA Fayetteville Gelatin powder for pharmaceuticals and food Harmony Labs Landis pharmaceuticals and cosmeceuticals Merck & Company Durham Vaccines manufacturing sector needs levels. This comprehensive strategy Sterile solutions and emulsions for infusion Novo Nordisk Research and testing products; contract an abundant supply of creates a continuum of education in Hospira Clayton and nutrition therapy Pharmaceutical Industries Clayton Human insulin formulation and sterile filling Molecular Toxicology Boone manufacturing specially trained workers, so scientific, technical and engineering Laboratory Corporation Purdue Pharmaceuticals LP Wilson Pain relief and asthma drugs Novartis Vaccines and disciplines. (www.ncbioimpact.com) of America Burlington, RTP Clinical laboratory services Diagnostics Holly Springs Vaccines we work hard to develop a Qualicaps Whitsett Pharmaceutical gel caps Metrics Greenville Analytical services Novozymes North America Franklinton Industrial enzymes job-ready workforce that can Sandoz Wilson Oral-dosage pharmaceuticals PharmAgra Labs Brevard Custom organic compounds Pfizer Poultry Health Maxton Poultry vaccines Cardiovascular, cancer and infectious disease help make businesses more PharmaCore High Point Organic chemical synthesis United Therapeutics RTP treatments Talecris Biotherapeutics Clayton Blood and plasma-related therapeutics productive and profitable.” Vintage Pharmaceuticals Charlotte Pharmaceuticals —Norris Tolson, President and CEO, Pisgah Labs Pisgah Forest Organic chemical synthesis Wyeth Pharmaceuticals Sanford Vaccines North Carolina Biotechnology Center or [email protected] at Bill 919-541-9366 Bullock world for biomanufacturing. Contact like Carolina Find out what makes in nowhere the else North biomanufacturing. challenges in anddevelopments issues, discuss and engineers Development in human capitalandbiotechnology workforce. ranked has Biotech report the Index Research Triangle area No. 1 in the world for the biomanufacturing.Milken Infact, Institute’s that training to dedicated second is andthe none largest facility system the ante ups with state aworkforce-development The create the ideal place for abiomanufacturing facility. science, climate unbeatable andgreat for quality of business life Carolina’sNorth thriving biotechnology top-notch industry, A Community Like Like N Community A With offices in offices With • 919-541-9366 15 T.W. Alex owhere El a a nder D nder fax sheville • ch sheville Bioprocessing and Process Biotechnology Process and Center’s Bioprocessing 919-990-9544 919-990-9544 Group, where process-development scientists scientists Group, process-development where rive • P.O.rive B of BIO Supporting that are community anumber Supporting Rounding the out mix areaffiliate the state of architecture, construction, engineering, of architecture, construction, plants inplants compliance with FDA requirements. design, builddesign, andvalidate bioprocessing instrumentation andconsulting firms that a , chapters of, chapters ISPE rl web ott o x 13547 •R x 13547 www e • greenville •w e •greenville g se I . .nc biot ese a ech. n T rch Tri rch , PDA o r ilming g a email

ngle P ngle he W he andASQ to inf n •w a 27709-3547 NC rk, o @nc ins , plus the, plus biot to or n-s ech. a lem o l r g d

08-005 CA 08/2008