Nutraceuticals Pages: 278

Freedonia Industry Study #1359 Study Publication Date: November 2000 Price: $3,700 Nutraceuticals Pages: 278

Nutraceuticals, a new study from The Freedonia Group, provides you with an in-depth analysis of major trends in the industry and the outlook for product segments and major markets -- critical information to help you with strategic planning.

This brochure gives you an indication of the scope, depth and value of Freedonia's new study, Nutraceuticals. Order- ing information is included on the back page of the brochure.

Brochure Table of Contents

Study Highlights ...... 2 Table of Contents and List of Tables and Charts ...... 4 Sample Pages and Sample Tables from: Market Environment ...... 6 Products ...... 7 Applications ...... 8 Industry Structure ...... 9 Company Profiles ...... 10 List of Companies Profiled ...... 11 Forecasting Methodology ...... 12 About the Company ...... 13 Advantages of Freedonia Reports ...... 13 About Our Customers ...... 14 Other Titles From Freedonia ...... 15 Ordering Information...... 16 Study Highlights

• US demand for nutraceuticals will increase 6.7 percent annually to $2.7 billion in 2004, serving end-use product markets totaling $34 billion.

• Herbal and related extracts will see the strongest growth based on expanding scientific evidence of health benefits and the rising popularity of alternative medicines.

• Vitamins and minerals will continue to be dominated by antioxidants (vitamins A, C and E), potassium and calcium.

• Among the nutrients, soy proteins, oat bran and psyllium will continue to comprise the largest-selling compounds due to health and wellness advantages and increasing uses in fortified foods and beverages.

• Ginkgo biloba for enhanced cognitive properties, St. John’s Wort for managing mild depression, ginseng for energy boosting, echinacea for strengthening immunity and saw palmetto for benign prostatic hyperplasia will provide the best growth prospects among herbs.

• While not approaching the boom projected previ- ously, herbal and related extracts will account for strong growth over the next half decade based largely on new applications in high value-added combination products.

• Roche (Switzerland), BASF (Germany), ADM Nutraceuticals, DuPont, Ajinomoto (Japan) and Lonza (Switzerland) comprise the six largest producers of nutraceutical chemicals, accounting for over 70 percent of the US market.

Nutraceuticals #1359 Freedonia Industry Study 2 Study Highlights Nutraceuticals Demand by Type, 1999

Vitamins & Minerals 48.3%

Herbal & Functional Additives 10.8%

Herbal & Related Extracts 40.9%

Nutraceuticals Demand (million dollars) % Annual Growth Item 1989 1999 2004 2009 99/89 04/99

Nutritional Product Shipments 15455 27590 34175 41500 6.0 4.4 $ nutraceuticals/000$ shipments 71.8 70.1 78.1 89.2 -0.2 2.2

Nutraceuticals Demand 1110 1934 SUMMARY2670 3700 TABLE5.7 6.7 By Type: Vitamins & Minerals 686 934 1120 1335 3.1 3.7 Nutrients & Functional Additives 373 791 1210 1840 7.8 8.9 Herbal & Related Extracts 51 209 340 525 15.1 10.2

By End Use: Specialty Nutritional Products 447 832 1205 1755 6.4 7.7 Dietary Supplements 396 687 915 1210 5.7 5.9 Fortified Foods & Beverages 267 415 550 735 4.5 5.8

Nutraceuticals #1359 Order form on last page 3 Table - Vitamin a Demand ...... 43 List of Contents, Retinol ...... 43 Beta Carotene ...... 44 Tables and Charts B-Group Vitamins ...... 46 Table - B-group Vitamins Demand ...... 47 Cyanocobalamin (Vitamin B12) ...... 47 Folic Acid ...... 49 Niacin (Vitamin B3)...... 50 Riboflavin (Vitamin B2) ...... 52 Pantothenic Acid (Vitamin B5) ...... 53 Pyridoxine (Vitamin B6)...... 54 I. EXECUTIVE SUMMARY Thiamin (Vitamin B1) ...... 55 Summary Table ...... 3 Other Vitamins ...... 56 Table - Other Vitamins Demand ...... 57 II. MARKET ENVIRONMENT Biotin ...... 57 General ...... 4 Vitamin K ...... 58 Economic Factors ...... 4 Vitamin D ...... 59 Table - Macroeconomic Indicators ...... 6 Minerals ...... 60 Demographic Patterns ...... 6 Table - Minerals Demand ...... 61 Table - Population & Age Distribution ...... 8 Electrolytes ...... 62 Health Care Trends ...... 8 Table - Electrolytes Demand ...... 63 Medical Conditions ...... 9 Potassium Electrolytes ...... 63 Table - Medical Conditions by Type...... 10 Sodium ...... 64 National Health Expenditures ...... 11 Essential Minerals ...... 65 Table - National Health Expenditures by Type...... 12 Table - Essential Minerals Demand ...... 66 Nutritional Products Overview ...... 12 Calcium ...... 66 Table - Nutritional Product Shipments by Type ...... 14 Table - Calcium Demand ...... 69 Fortified Foods & Beverages ...... 14 Magnesium ...... 69 Specialty Nutritional Products ...... 16 Table - Magnesium Demand ...... 71 Dietary Supplements ...... 17 Phosphorus ...... 71 Regulatory Considerations ...... 18 Table - Phosphorus Demand ...... 72 Zinc ...... 73 III. NUTRACEUTICALS OVERVIEW Table - Zinc Demand ...... 74 General ...... 19 Iron ...... 74 Table - Nutraceuticals Demand by Product Group ...... 20 Table - Iron Demand ...... 76 Demand Patterns ...... 20 Trace Minerals ...... 76 Chart - Nutraceuticals Demand by Type, 1999 ...... 23 Table - Trace Minerals Demand ...... 77 Pricing Trends ...... 23 Chromium ...... 77 Table - Nutraceuticals - Market & Pricing Trends...... 25 Copper ...... 79 US Trade in Nutraceutical Chemicals ...... 25 Other Trace Minerals ...... 80 Table - Us Trade in Nutraceuticals ...... 27 International Markets 27 ...... V. NUTRIENTS & FUNCTIONAL ADDITIVES Table - World Nutraceuticals Demand ...... 29 General ...... 84 Table - Nutrients & Functional Additives Demand ...... 85 IV. VITAMINS & MINERALS Proteins ...... 85 General ...... 30 Table - Proteins Demand ...... 86 Table - Vitamins & Minerals Demand ...... 31 Soy Proteins ...... 87 Vitamins ...... 31 Amino Acids...... 89 Table - Vitamins Demand ...... 32 Fibers ...... 90 Vitamin Demand Patterns ...... 32 Table - Fibers Demand ...... 91 Vitamin C ...... 35 Oat Bran ...... 92 Table - Vitamin C Demand ...... 36 Psyllium...... 93 Vitamin E ...... 39 Cellulose ...... 93 Table - Vitamin E Demand ...... 39 Soy Fibers ...... 94 Vitamin A ...... 43 Other Fibers ...... 94

Nutraceuticals #1359 Freedonia Industry Study 4 Coenzyme Q-10 ...... 143 Functional Additives ...... 95 Melatonin ...... 144 Table - Functional Additives Demand ...... 96 Other Nonherbal Extracts ...... 145 Caloric Agents ...... 96 Polyunsaturated Fatty Acids (PUFAs) ...... 98 VII. END-USE APPLICATIONS Tocotrienols ...... 100 General ...... 147 Isoflavones ...... 101 Table - Nutraceuticals Demand by End-Use Product ...... 148 Lycopene ...... 102 Specialty Nutritional Products ...... 148 Sterols ...... 102 Table - Nutraceuticals Demand Probiotics ...... 103 in Specialty Nutritional Products ...... 149 Other Functional Additives ...... 104 Demand Patterns ...... 149 Nutraceutical Applications ...... 150 VI. HERBAL & RELATED EXTRACTS Dietary Supplements ...... 151 General ...... 108 Table - Nutraceuticals Demand in Dietary Supplements .....152 Table - Herbal & Related Extracts Demand ...... 108 Demand Patterns ...... 152 Herbal Extracts ...... 109 Product Applications ...... 153 Table - Herbal Extracts Demand ...... 111 Fortified Foods & Beverages ...... 154 Ginkgo Biloba...... 112 Table - Nutraceuticals Demand Table - Ginkgo Biloba Demand ...... 114 in Fortified Foods & Beverages ...... 155 St. John’s Wort ...... 114 Demand Patterns ...... 155 Table - St. John’s Wort Demand ...... 116 Product Applications ...... 156 Ginseng ...... 116 Table - Ginseng Demand ...... 118 VIII. INDUSTRY STRUCTURE Garlic ...... 119 General ...... 157 Table - Garlic Demand ...... 120 Market Share ...... 157 Echinacea ...... 121 Chart - Market Share of Leading Table - Echinacea Demand ...... 122 US Nutraceutical Chemical Companies, 1999 ...... 158 Saw Palmetto ...... 122 Competitive Strategies ...... 158 Table - Saw Palmetto Demand ...... 124 Table - US Nutraceutical Sales by Company, 1999 ...... 164 Chamomile ...... 124 Mergers & Acquisitions ...... 167 Table - Chamomile Demand ...... 125 Table - Selected Acquisitions & Divestitures ...... 168 Spirulina ...... 126 Licensing & Related Agreements ...... 170 Table - Spirulina Demand ...... 128 Table - Selected Cooperative Agreements ...... 171 Kava Kava ...... 128 Marketing & Distribution ...... 178 Table - Kava Kava Demand ...... 130 Manufacturing ...... 178 Goldenseal ...... 130 Company Profiles ...... 179-278 Table - Goldenseal Demand ...... 131 Grape Seed ...... 131 Table - Grape Seed Extract Demand ...... 132 Cranberry ...... 133 Table - Cranberry Demand ...... 133 Valerian ...... 134 Table - Valerian Demand ...... 135 Black Cohosh ...... 135 Table - Black Cohosh Demand ...... 136 Other Herbal Extracts ...... 136 Table - Other Herbal Extracts Demand ...... 137 Evening Primrose ...... 137 Feverfew ...... 138 Ginger ...... 138 Hawthorn ...... 139 Milk Thistle ...... 139 Peppermint ...... 139 Miscellaneous Herbal Extracts ...... 140 Nonherbal Extracts ...... 141 Table - Nonherbal Extracts Demand ...... 141 Glucosamine & Chondroitin ...... 142

Nutraceuticals #1359 Order form on last page 5 Market Environment

The Market Environment Section discusses factors influencing nutraceutical demand, including the

outlook for nutritional products and MARKET ENVIRONMENT health care trends.

Fortified Foods & Beverages This information provides you with an understanding and an analysis of the Nutraceutical ingredients are used to fortify the nutritional content of a wide range of conventional foods and beverages. Within this product group, cereals and climate in which the nutraceutical sports drinks comprise the largest demand for traditional vitamins, minerals and industry operates. essential nutrients. US shipments of cereal products will increase 4.2 percent annually to $16.2 SAMPLEbillion in 2004. PAGE The expanding popularity of nutritionally enriched energy and health bars will contribute significant momentum to growth. By contrast, the widening acceptance of bulk-packaged private-label brands by consumers will weaken the pricing flexibility of traditional breakfast cereals and slow overall increases in shipments. Nonetheless, preferences throughout the population for healthier offerings will keep the demand for nutraceuticals in cereal products advancing steadily.

Sports drinks such as GATORADE (Quaker Oats) have built up an attractive specialty niche within the beverage industry, providing a convenient method for replenishing depleted mineral levels commonly occurring among athletes and exercise active individuals. Benefiting from continuing consumer pursuits of healthier, active lifestyles, combined US shipments of these products is projected to increase 4.7 percent annually to $735 million in 2004. Growth opportunities for nutraceuticals in sports beverages will extend to several minerals as well as energy-boosting herbal supplements such as ginkgo biloba and ginseng.

Cereal products and sports drinks will provide steadily expanding demand for traditional vitamins, minerals and nutrients. However, the best growth opportunities for nutraceuticals in conventional foods and beverages will emerge in nutrients and functional additives with broader health and nutritional benefits. These substances, which include soy proteins, isoflavones, polyunsaturated fatty acids, tocotrienols, carotenoids, probiotics and several other high value-added com-

Nutraceuticals #1359 Freedonia Industry Study 6 Products

PRODUCTS

The Product Sections provide demand Oat Bran for historical years and forecast growth to 2004 and 2009. Demand for oat bran fibers in nutraceutical applications will reach $74 million in 2004, up 5.5 percent annually from 1999. ClinicallySAMPLE proven PAGEand Food and Drug Administration (FDA)-approved cholesterol reducing properties will foster growth This information helps you: by broadening uses in food and beverage fortification and specialty nutritional preparations. Increasing competition from psyllium and other nutraceuticals with similar health benefits will inhibit faster sales gains. • Analyze your company's growth potential in The US sales potential of oat bran fibers as nutraceutical ingredients expanded significantly in early 1997 when the FDA endorsed the results of a clinical study the industry. sponsored by Quaker Oats (Chicago, Illinois). This study confirmed that diets high in the substance were associated with lower cholesterol levels and a reduced • Outline your strategic risk of heart disease. Producers of foods, beverages and other products containing oat bran fibers are now authorized to advertise these health benefits both in the plans for five and ten media and on packages. years out. Spurred by FDA acceptance of cholesterol reducing properties, oat bran fibers are being adapted to an increasing range of nutraceutical products. This substance is • Establish sales goals. found in several brands of breakfast cereals and nutritional bars. Additionally, a number of nutraceutical beverages are based partially or completely on oat bran fibers. For example, Hain Food Group’s WESTBRAE OATPLUS nutritional drink blends oat bran fiber with several vitamins and minerals.

Besides reducing cholesterol, oat bran fibers have been shown to aid sleep and alleviate dry skin. Additionally, increasing scientific evidence indicates that these nutraceuticals are effective in alleviating indigestion and managing depression. Ginseng DemandFavorable health benefits will keep oat bran fibers a widely used nutraceutical ingredient. However, growth opportunities for the substances will decelerate slightly over the next several years as consumer demand for primary end-use Item 1989 1994 1999 2004 2009 products becomes more saturated. Herbal Extracts Demand (000 lbs) 9450 16945 28010 38900 51200 % ginseng 14.5 13.4 14.3 14.4 14.9 SAMPLE TABLE Ginseng Demand (000 lbs) 1369 2266 4010 5600 7650 $/lb 3.36 3.84 3.94 4.11 4.27

Ginseng Demand (mil $) 4.6 8.7 15.8 23.0 32.7

% ginseng 13.5 12.1 11.9 11.3 11.2 Herbal Extracts Demand (mil $) 34.0 72.0 133.0 203.0 293.0 © Copyright by The Freedonia Group, Inc.

Nutraceuticals #1359 Order form on last page 7 Applications

The Applications Section analyzes trends and considers the threats and opportunities in each of the major applications for

nutraceuticals. END-USE APPLICATIONS

The information presented will Dietary Supplements help you: The second largest end-use application served by nutraceutical ingredients • Focus your sales and marketing encompass dietary supplements. Consisting of nutritional preparations and efforts on high growth areas. alternative medicines produced in tablet, capsule and oral liquid dosage forms, these products provide significant sales opportunities for most vitamins and minerals as well as many herbal and related extracts. In addition, soy proteins and a number of • Propose new areas for development. other nutrients are emerging as important ingredients of new dietary supplements aimed at treating specific conditions such as menopausal symptoms. Based on anticipated new product introductions and evolving consumer preferences for higher value-added formulations, combined demand for nutraceuticals in dietary SAMPLE PAGE supplements will increase almost six percent annually to $915 million in 2004.

Demand Patterns

Dietary supplements will provide mixed growth opportunities for nutraceutical ingredients. Increasing consumer preferences for broad-based formulations which Nutraceuticals Demand inmeet Specialty a wide variety Nutraceutical of nutritional and preventive Products medicine needs will impact (million dollars) favorably on demand. By contrast, the decreasing popularity of single ingredient vitamin and mineral supplements and alternative medicines will weaken sales prospects for many ingredients. In general, the results of clinical and research Item 1989 1994 1999 2004 2009 studies will determine the demand potential for various nutraceuticals in dietary Specialty Nutritional Products Shptssupplements. For5300 the most7369 part, ingredients9915 12275with established14900 proof of safety and $ nutraceuticals/000$ shpts effectiveness will 84fare better79 in the marketplace84 than98 ingredients118 lacking such evidence. However, nutraceuticalsSAMPLE sold on the TABLE basis of attractive benefits such as Specialty Nutritional Products Demandreversal of aging,447 cancer prevention585 and832 weight1205 loss will1755 continue to generate Vitamins & Minerals favorable demand215 irrespective245 of clinical286 and research324 findings.363 Nutrients & Functional Additives 229 333 533 856 1350 Herbal & Related Extracts 3 7 13 25 42

% specialty nutritional products 40.4 41.4 43.3 45.4 47.7 Nutraceuticals Demand 1106 1413 1923 2655 3680 © Copyright by The Freedonia Group, Inc. © Copyright by The Freedonia Group, Inc.

Nutraceuticals #1359 Freedonia Industry Study 8 Industry Structure Sample page from Freedonia Industry Study

Gain#1117 a better Fractional understanding Horsepower of your Motors competition and analyze your company's position in the industry with information about:

• market share INDUSTRY STRUCTURE

• competitive strategies Marketing & Distribution

Marketing and distribution strategies vary widely among suppliers of nutraceuti- • manufacturing cals. Most larger companies, such as BASF and Roche, operate large sales organizations which serve major customers directly. By contrast, smaller firms SAMPLE PAGE • marketing & distribution offering one or two products and offshore producers typically sell through national distributors. Leading US distributors of nutraceuticals include Ashland • mergers & acquisitions and Sigma-Aldrich Fine Chemicals, both of which also manufacture several types of compounds. Among other products, Ashland has emerged as a broad line supplier of imported herbal extracts. Nutraceuticals available from Sigma-Aldrich • licensing & related agreements Fine Chemicals encompass most major types of vitamins, minerals and nutrients used by food and drug manufacturers.

As industry competition intensifies, major nutraceutical chemical companies are focusing marketing strategies toward achieving differentiation. Cognis Nutrition and Health, for instance, has assigned brand names to most of its products including COVI-OX, COVITOL, BETATENE and LIPOEC to vitamin E. Additionally, the company actively pursues licensing and distribution rights to innovative compounds developed by smaller, research-oriented concerns. For example, in February 1997, Cognis entered into an agreement with Horphag Research Limited (United Kingdom) to serve as the exclusive North American distributor of PYCNOGENOL, a maritime pine bark extract containing 40 water- soluble antioxidants and organic acids.

Manufacturing

Due to the limited pricing flexibility of many compounds, producers of nutraceuticals have been pursuing cost-saving strategies based on technological advances in manufacturing processes. Beyond cost considerations, stricter GMP (good manufacturing practices) regulations on dietary supplements and herbal extracts

Nutraceuticals #1359 Order form on last page 9 Company Profiles

The Profiles Section analyzes 36 companies active in the U.S. nutraceuticals market. These profiles represent a sampling or cross-section of the types of

companies involved in the industry. COMPANY PROFILES

Divisions, subsidiaries, joint Lonza Group Limited Feldeggstrasse 4 ventures, etc., are discussed under 8034 Zurich appropriate parent companies. Switzerland 41-1-386-2222

Sources for profiles included: Lonza Incorporated 17-17 Route 208 • Information provided by Fair Lawn, NJ 07410 201-794-2400 key staff members in the respective companies Lonza Group was formed in November 1999 when Alusuisse Lonza Group Limited (Switzerland) demerged its specialty and fine chemical operations. Lonza • Annual reports Group is a leading manufacturer of fine chemicals for the life sciences industry, including biotechnology, organic chemicals, intermediates and actives. The Company operates in three divisions: Fine Chemicals and Specialties; Intermedi- • 10-K reports ates and Additives; and Energy. In 1999, Lonza Group had sales of $1.5 billion and employed 5,700. SAMPLE PAGE • Security analysts reports Lonza Group is active in the nutraceuticals industry through its Fine Chemicals and Specialties division, which had 1999 sales of $1.1 billion. This division • Corporate product literature operates through Lonza Limited (Switzerland) and its various subsidiaries. Lonza Limited develops, manufactures and markets active substances, intermediates and additives used in such applications as vitamins, food, pharmaceuticals, animal feed, cosmetics, fragrances, dyes and pigments, adhesives, industrial products and crop protection.

Lonza Limited manufactures several products which can be used for nutraceutical applications. These products include niacin, hydrocyanic acid derivatives,

Nutraceuticals #1359 Freedonia Industry Study 10 Companies Profiled

Abbott Laboratories Hauser Incorporated Ross Products Botanicals International Extracts Ajinomoto Company Incorporated Wilcox Drug Company Incorporated American Home Products Corporation ZetaPharm Incorporated Solgar Vitamins and Herb Company Inc. Zuellig Botanical Extracts Incorporated Whitehall-Robins Healthcare Henkel KGaA Wyeth-Ayerst Cognis Corporation Archer-Daniels-Midland Company HCS Nutritional Resources LLC Ashland Incorporated Herbalife International Incorporated BASF AG Johnson & Johnson Bayer AG McNeil Consumer Healthcare Company Bio-Botanica Incorporated Personal Products Company Boehringer Ingelheim GmbH Lonza Group Limited Pharmaton Natural Health Products Martek Biosciences Corporation Bristol-Myers Squibb Company Merck KGaA Mead Johnson Nutritionals EM Industries Incorporated Cargill Incorporated Novartis International AG Carrington Laboratories Incorporated Altus Food Company Caraloe Incorporated Nutraceutical International Corporation Cyanotech Corporation Action Labs Incorporated Daiichi Pharmaceutical Company Limited Pharmacia Corporation Dainippon Ink and Chemicals Incorporated Monsanto Company Earthrise Nutritionals Incorporated Roche Holding Limited DuPont (EI) de Nemours Hoffmann-La Roche Incorporated Protein Technologies International Inc. Royal Numico NV So Good International Efamol Limited E.ON AG Enrich International Incorporated ASTA Medica AG MET-RX Nutrition Incorporated Degussa-Huels Corporation Rexall Sundown Incorporated SKW Trostberg AG Worldwide Sport Nutritional Supplements Inc. Traco Labs Incorporated Sankyo Company Limited VEBA AG Scotia Holdings plc VIAG AG Takeda Chemical Industries Limited Eastman Chemical Company Universal Foods Corporation Eisai Company Limited Red Star Yeast and Products Hain Celestial Group Incorporated Celestial Seasonings Incorporated Westbrae Natural Incorporated

Nutraceuticals #1359 Order form on last page 11 Forecasting Methodology

Freedonia does not just collect and reprint data; Freedonia develops data. Our analysts thoroughly investigate an industry by extensively interviewing key industry participants and analyzing information from sources such as associations, government and trade literature. Once this The Freedonia research is complete, Freedonia establishes Economics Group Freedonia one set of forecasts. All writing, editing In-house Research Consistent framework and forecasting is done in-house to assure of economic indicators on . . . • Quantitative forecasting quality and consistency. In cases where • Vitamin Demand • Industry structure & market • Resident Population data does not exist, Freedonia develops the share analyses • Gross Domestic Product (GDP) • Product analyses & forecasts data based on input/output ratios, bills of . . . and many others materials and flow charts. The following chart summarizes Freedonia's methodology:

Methodology for Nutraceuticals

Proprietary Extensive Interviews Electronic Database • Key participants • Trade publications • Industry experts • Government reports • End-users • Corporate literature • Online databases . . . and many others

Nutraceuticals #1359 Freedonia Industry Study 12 The Freedonia Group, Inc. is a leading international industry study/ About database company. The Freedonia Group Since 1985, Freedonia has published over 1,500 titles covering areas such as chemicals, coatings and adhesives, building materials, plastics, industrial components and equipment, health care, packaging, household goods, security, and many other industries.

Freedonia has produced a wide variety of titles, including:

• World Nutraceuticals • Pharmaceutical Chemicals • Biotechnology Pharmaceuticals • Artificial Sweeteners & Fat Replacers

Because Freedonia is a reliable information source, our forecasts are cited in numerous publications such as The Wall Street Journal, Chemical Market Reporter, Chemical Week and The Financial Times.

Advantages In-house operations of Freedonia Reports Because all of our staff work at the same location, interaction between analysts and departments provides a strong system of checks and balances.

Consistency Our Economics Group develops indicators that are used by all analysts. Therefore, every Freedonia study is based on a consistent set of economic assumptions (GDP, vitamin demand, resident population, etc.)

Reliable forecasts Because all of our forecasts consider the environment in which a product or industry is operating, as well as threats and opportunities to the market, Freedonia forecasts are reliable indicators of future performance.

One-on-one interviews All studies are produced by conducting interviews with key industry participants and end-users.

Proprietary electronic database Freedonia’s analysts can tap into an extensive in-house electronic database containing corporate literature (including private company information), trade publications, government reports and many other sources of information.

Nutraceuticals #1359 Order form on last page 13 About Our Customers

Freedonia's clients include major US and international companies in the manufacturing, services, consulting and financial sectors.

Typical purchasers of Freedonia studies :

• Key Executives • Corporate Planners • Market Researchers • Financial Analysts • Information Centers • New Product Developers • Merger & Acquisition Specialists

Since 1985 we have provided research to customers ranging in size from global conglomerates to one person consulting firms. More than 90% of the industrial companies in the Fortune 500 use Freedonia research to help with their strategic planning.

Some of Freedonia's customers in the nutraceuticals market include: Abbott Laboratories, Cargill Incorporated, Henkel KGaA and Johnson & Johnson.

Nutraceuticals #1359 Freedonia Industry Study 14 Nutraceuticals - Private Companies Report Private companies are active as producers, for- Other Titles mulators, blenders and distributors of nutraceuticals and/or nutritional products which use nutraceuticals as ingredients. Over five private From Freedonia firms have related sales of over $50 million. This report profiles over 150 privately-held companies (e.g., Amway, Boehringer Ingelheim, Cargill, World Electronic Components Leiner Health Products, AM Todd Group). The World electronic component demand will grow report also includes industry demand forecasts, over 9% annually based on further development For more information about recent acquisition and consolidation trends, and of the Internet, new generations of handheld and wireless computers, and rising electronic content these or other Freedonia titles, lists of companies by product and location. #1387...... 2/01...... $3,200 in original equipment. High-end integrated cir- please contact us at: cuit (IC) devices such as microprocessors and digital logic ICs will lead gains. This study analyzes the $278 billion world electronic compo- The Freedonia Group, Inc. Amino Acids nents industry to 2004 and 2009 by product, Demand for methionine, lysine and threonine will market and region, and for 33 countries. It also Phone: (440) 684-9600 experience volume growth as a result of increas- details market shares and profiles key vendors. (800) 927-5900 ingly sophisticated livestock feed regimens. Phar- #1322...... 10/00...... $4,500 maceutical and nutraceutical applications will also Fax: (440) 646-0484 fare well. This study analyzes the US market for amino acids through 2004 and 2009. Other key products covered include phenylalanine, cysteine Pharmaceutical Chemicals and tryptophan. Historical data and forecasts are presented in US dollars by product and market. US demand for pharmaceutical chemicals will increase 7% annually. Bulk hormones and related The study also presents market share data and profiles key industry participants. agents will see the fastest growth based on new bioengineered compounds for cancer, diabetes #1379...... 2/01...... $3,600 and infertility. Respiratory chemicals will also do well spurred by improved asthma and allergy therapies. This study analyzes the $14.6 billion Artificial Sweeteners & Fat Replacers US pharmaceutical chemicals industry to 2004 Demand for artificial sweeteners and fat replacers and 2009 by therapeutic class, regulatory status, in the US will grow to $1.2 billion in 2004. and production source. It also presents market Gains will be spurred by health-conscious con- share data and profiles key industry players. sumers seeking to moderate sugar and caloric in- #1311...... 8/00...... $3,800 take without sacrificing taste and texture. Fat replacers will grow over 7% annually, while artificial sweeteners advance at a more moderate rate. This study analyzes the $986 million US artifi- World Nutraceuticals cial sweetener and fat replacer industry to 2004 World demand for nutraceuticals will grow over and 2009 by product and market. It also evalu- 10% per year. Functional food additives will ates market share and profiles key firms. grow the fastest spurred by new products, broad- #1346...... 11/00...... $3,500 ening end-use applications, greater pricing flexibility and increasing number of health conscious consumers. Global demand for herbal extracts Biotechnology Pharmaceuticals will also advance at a strong pace. This study analyzes the $6.8 billion world nutraceutical in- US demand for biotech drugs will grow almost dustry by product group in six geographic regions 13% annually. Gains will be driven by new prod- and 12 individual countries. It also details mar- ucts as continuing advances in biotechnology en- ket share and profiles key producers. able drug researchers to develop safe and effec- #1289...... 6/00...... $4,600 tive medicines for conditions not adequately treated with conventional pharmaceuticals. Faster regulatory review will also benefit demand. This study analyzes the $15.7 billion US biotech drug industry to 2004 and 2009 by type, technology and application. It also presents market share data and profiles leading companies. #1338...... 10/00...... $3,700

Nutraceuticals #1359 Order form on last page 15 How to Order

Ordering Information For more information about our products, Fill out the coupon below and mail it to The Freedonia Group, or send your order by fax (440) 646-0484, or E-mail to please call the Freedonia Customer Service [email protected] Department at (440) 684-9600 or (800) 927-5900 or fax (440) 646-0484. Handling and Shipping is FREE There is NO charge for handling and shipping. In the US we ship via UPS. Outside the US, we provide free airmail service. If you would like express delivery, we provide this to you at cost. Discounts If your order is accompanied by a check, you may take a 5% cash discount. If you order three (3) separate industry studies and/or private company reports at the same time, you are entitled to a 15% discount. Use Credit Card You may charge your order to either Visa, MasterCard or American Express. Please include your credit card account number, expiration date and your signature. Orders Outside of the US Checks must be paid in US funds and drawn against a US bank. Wire transfers should be sent to: Fifth Third Bank, Cincinnati, Ohio; The Freedonia Group, Inc.; SWIFT #FTBCUS3C; ABA #042000314; Account #830-51814 (please include study number and/or invoice Intranet Licenses number with all wire transfers).

Intranet licenses are available for one or more Additional Copies Additional copies are available to original purchasers at $400 per title. users. For information about obtaining a Freedonia intranet license, contact our cus- Online Access tomer service department. The complete text and tables from our studies and reports can be found on our Web site www.freedoniagroup.com and through major commercial online vendors.

THE FREEDONIA GROUP, INC. TITLE PRICE 767 Beta Drive Cleveland, OH 44143-2326 USA Phone: (440) 684-9600 • (800) 927-5900 #1359 Nutraceuticals $3,700 Fax: (440) 646-0484

Name:

Title:

Company:

Division: Please check method of payment: Total: $ Street: Enclosed is my check (5% discount) drawn on a US bank and payable to The Freedonia (no PO Box please) Group, Inc., in US funds. (Ohio residents add 7% sales tax). City/State/Zip: Bill my company MasterCard Visa American Express

Country:

MO. YR. Phone: Fax:

Email: Credit Card # Expiration Date SHIPPING and HANDLING charges are FREE via UPS (USA only) or airmail. Express delivery available at cost. Signature: INQ Please inquire.