The Magazine You Can Count On

EST.1977 1978 1979 1980 1981 www.pharmtech.com 1982 1983 1984 1985 1986 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 THE MAGAZINE 1997 YOU CAN COUNT ON 1998 MANUFACTURING/PROCESSING EQUIPMENT 1999 OUTSOURCING 2000 COMPLIANCE & VALIDATION CHEMICALS 2001 EXCIPIENTS AND APIs 2002 DRUG DELIVERY ASEPTIC/STERILE PROCESSING 2003 LAB EQUIPMENT 2004 PACKAGING 2005 2006 MEDIA PLANNER CALENDAR AND RATES INSIDE The PharmTech Brand

Print-based Marketing

Pharmaceutical Technology DISPLAY ADVERTISING The foundation of any B-to-B marketing program, print advertising allows offers Marketing and you to touch 38,600 BPA-Qualified subscribers* with your brand or product message. Build your marketing plan around the message conveyed in your Brand Managers an array print ad and utilize other channels to further reinforce your message. of products geared to CUSTOM PUBLISHING Work with us to write and design a custom white paper or article create deep penetration into published as an advertorial. Material for this white paper can be gathered from events such as a reader roundtable or Webinar offered our highly targeted audience. by Pharm Tech and delivered through print, email and web-based channels that incorporate lead generation mechanisms. Make the most of your marketing INSERT efforts by participating A unique way to deliver white papers, brochures, or any other collateral material to our readers. in a tailored program. POLYBAG Our highly trained sales Talk about premium placement! Send your printed piece as a ride-along, and readers will get the message as soon as the issue hits their desks. consultants will utilize mediums POST–IT NOTE A unique way to send your message to our readers, Post–It Notes serve as that fit your specific needs. front cover reminders about your brand. Use Post–Its to call out your ads in the issue, or run 6 or 12 Post–It Notes for a truly extraordinary campaign.

BUSINESS REPLY CARD An efficient and effective direct response medium, BRCs can be used to promote a contest or simply to provide our readers with a distinct opportunity to contact you for more information.

DIRECT MAIL Planning a direct mail campaign to reinforce your ad message? Rent our list to ensure your marketing material reaches your most important audience.

COVER TIP Have a special offer, new product announcement or just want to call attention to your company’s products? Cover tips are a great way to get noticed and are much more cost effective than mailing to that same number of subscribers.

Pharmaceutical Technology's authoritative reputation and powerful brand recognition within the pharmaceutical development & manufacturing marketplace will help you establish and maintain your own strong brand among pharma industry decision makers. A circulation of 38,600 BPA-qualified subscribers* and unmatched peer written and reviewed editorial make Pharmaceutical Technology an invaluable resource within top pharma companies, as well as small, specialty and biotech pharma companies spending billions each year on pharmaceutical development and manufacturing.

* BPA June 2005 Statement

Web-based Marketing

E-NEWSLETTER ePT is a weekly newsletter offering unique opportunities to surround your advertisement with content relevant to your brand, and route buyers to a page on your site specific to your message.

E-ZINE PT Electronic, delivered monthly to 60,000+^ readers, offers unique content, increased connectivity, and deeper market penetration.

WEBINAR Work with us to create an on-line event that will help you address key industry issues among the people who are critical to the industry.

E-MMERCIALS Another dynamic way to send your marketing message to our audience. Capture the attention of readers with this exciting flash presentation tool. Deliver your E-mmercial via a targeted email, post it on our site, and use it in your own site, on sales calls and at your trade show booth.

MARKETPULSE Allow us to deliver the answers to your most pressing questions with a customized on-line survey of our readers.

PRODUCTBLAST You provide the links and the message, and we provide the community. Blast your product offerings, on-line catalogue, or newest product announcements with ProductBlast. Sent to select readers, based on your demographic target, ProductBlast is an effective way to spread the word about your products, and directly link readers to them.

WEB SITE There are many opportunities on pharmtech.com. Banners, buttons, skyscrapers, big-box ads, product spotlights, and QuickPolls all provide unique ways for sellers to connect with buyers online.

E-NTERVIEWS Extend your trade show message! You provide a spokesperson to deliver your product message in a Q&A format. We provide the camera crew, edit the footage and produce a 5 minute video for email distribution the next morning, to readers in your demographic selects. Also, available via links in the email and on the web site.

E-SHOW DAILIES Deliver news from your conference or trade show to thousands in your industry—— even if they're not at the event! We’ll send a reporter to cover your conference who will produce an E-Show Daily hosted on our site. An email will be pushed the next morning, to readers in your demographic selects, and available on the site with links directing users to show coverage.

E-CARD DECK E-Card Deck——an electronic medium where advertisers successfully interact with purchasers——is an e-business reply card that provides the functionality that today’s decision makers require by using state-of-the-art technology to relay a marketing message with added benefits such as: • Push technology to a select group at an optimal time • Trackable results relating the effectiveness of your ad • Speed of delivery • Cost effectiveness and high ROI compared with Immediate delivery results traditional direct mail campaigns and limited mailing • list capabilities • Customer-friendly response capability via a link back to a page or a form on your website

Face-to-Face Marketing

PHARMACEUTICAL CONFERENCES Our branded conferences bring Pharmaceutical Technology’s audience and our expert content to life. Partner with PharmTech to make contact with the most influential professionals in your market.

SINGLE-SPONSOR EVENT Do you have an idea for a conference but lack the resources to bring your target community together? Partner with us to launch a conference focused on your objectives.

READER ROUNDTABLE You provide the topic, and we will provide a roundtable of readers selected from your target demographic, and facilitate your meeting. Think of it as your very own expert focus group.

^ Publisher’s Own Data The PharmTech Audience: Circulation

Over the years, Pharmaceutical Technology has built and grown a circulation of 38,600 BPA-qualified subscribers*. We’ve cornered the market on R&D, QA/QC, Production/Manufacturing/Engineering and related job functions at top Pharma and Biotech manufacturing companies.**

REACH KEY DECISION-MAKERS THROUGHOUT THE DEVELOPMENT AND MANUFACTURING PROCESS:

5.1% Universities (1,986) BUSINESS AND INDUSTRY* 3.5% Consultant to the Pharmaceutical Industry (1,363)

3.3% Drug Delivery Devices & Instrumentation Manufacturing (1,265)

82.2% 2.6% Government (1,009) Pharmaceutical & 1.6% Architecture/Engineering/Construction (615) Biopharmaceutical Manufacturing/ Contract Research/Analytical Services/ 1.5% Other Paid Circulation: Subscriptions (593) Specialty Chemicals, Bulk Products & 0.1% Others Allied to the Field (25) Raw Material Producers (31,744)

IN A VARIETY OF JOB FUNCTIONS *

Engineering (4,428) 11.5% 33.1% Production Manufacturing (3,688) 9.6% Research & Development (12,758) Corporate Management (2,450) 6.4% Technical/Analytical Service/Support (1,446) 3.7% Marketing and Sales Management (1,440) 3.7% Regulatory Affairs (1,288) 3.3% Lab Management (1,227) 3.2% Other Functions Allied to the Field (1,095) 2.8% Project Management (857) 2.2% Information Technology (431) 1.1% Materials Manufacturing/Purchasing (278) 0.7% 18.7% Quality Control/Assurance Validation (7,214)

* BPA June 2005 Statement ** Publisher’s Own Data

PHARMACEUTICAL TECHNOLOGY DELIVERS THE LARGEST AVERAGE QUALIFIED CIRCULATION WITH THE HIGHEST PERCENTAGE OF DIRECT REQUEST SUBSCRIPTIONS*

uring uring

act act t t s s ulation c ulation eque eque c ech Manuf ied Cir ech Manuf t t ar ect R io ar e ect R io ar ar e ied Cir QC QC ar ar e e e e A/ A/ ee Y ee Y al Dir Q Q o Y o Y al Dir t / / hr t w w hr o o age Qualif &D f One Y f T f T f T al Qualif &D f One Y f T f T f T t er o v T A # Pharma/B % Pharma/B # R % R # o % o # o % o # o % o # o % o

Pharmaceutical 38,600 35,280 27,986 72.5% 19,972 51.7% 31,992 82.9% 6,608 17.1% 0 0.0% 32,999 85.5% Technology

American 12,406 12,616 5,891** 47.4%** 5,304 42.8% 6,119 49.4% 2,336 18.8% 3,951 31.8% 12,379 99.8% Pharmaceutical Outsourcing American 30,266 30,205 15,513** 51.2%** 11,162 36.9% 19,497 64.4% 4,661 15.4% 6,108 20.2% 20,609 68.1% Pharmaceutical Review Contract Pharma 20,000 20,003 9,856 49.1% 6,724 33.6% 15,071 75.4% 4,562 22.8% 367 1.8% 19,982 99.9%

Drug Delivery Not Technology Audited

Pharmaceutical Not Formulation Audited

Pharmaceutical 25,050 25,041 18,296** 73%** 7,210 28.8% Not Not Not Not Not Not Not Not Manufacturing Reported Reported Reported Reported Reported Reported Reported Reported Pharmaceutical 31,020 31,016 24,374*** 78.7%*** 12,970 41.8% 24,900 80.3% 6,120 19.7% 0 0.0% 26,538 85.6% Processing Tablets & Capsules 9,550 9,649 7,748**** 81.1%**** 2,886 30.0% 8,727 91.4% 823 8.6% 0 0.0% 6,724 70.4%

REACH INDUSTRY LEADERS AT TOP COMPANIES ^ [# of Subscribers]

Pfizer 1548 Alcon 155 Solvay 76 KOS 55 Wyeth 1030 3M 146 Medimmune 75 Millennium 53 Merck 934 Chiron 145 Perrigo 75 MDS 52 Eli Lilly 820 Dow 142 Waters 72 Sigma Aldrich 51 Abbott 818 Allergan 135 Patheon 71 Alkermes 50 GlaxoSmithKline 679 Tyco 135 Jacobs Engineering 70 Leiner Health Products 50 Schering-Plough 618 Barr Labs 134 Roxane Pharmaceutical 70 Icos 47 Bristol-Myers Squibb 591 Hospira 105 King Pharmaceuticals 68 Merial 47 Amgen 548 Forest 104 Lonza 68 Steris 47 Johnson & Johnson 456 Mylan 104 Schwartz Pharma 68 Cima Labs 46 Sanofi-Aventis 438 Quintiles 101 Eisai 66 Colorcon 46 Baxter International 432 Cambrex Bio Science 97 Elan Corp 66 Dey Labs 46 Hoffman-LaRoche 424 Alpharma 96 Millipore 66 KV Pharmaceutical 46 Bayer 380 American Pharmaceutical Partners 92 Nektar Therapeutics 66 Thermo 46 Cardinal Health 278 Cephalon 91 Imclone 65 Banner Pharma 45 AstraZeneca 250 Ivax 89 Shire Laboratories 64 Saic Frederick 45 Genentech 230 Berlex 86 Bausch & Lomb 62 Fujisawa 44 Watson 219 Purdue Frederick 86 Diosynth 61 Celltech 43 Boehringer Ingelheim 199 Gilead 84 Organon 59 Novo Nordisk 43 Genzyme 195 DSM Pharmaceuticals 83 Ben Venue 57 GE Healthcare 42 Novartis 194 Human Genome Sciences 83 Biovail 57 Lancaster Labs 42 Centocor 192 AAI Pharma 82 PPD Inc. 57 Bio Rad 41 Alza 177 Andrx 80 DPT Labs 56 Upsher-Smith 41 Biogen 174 Regeneron 79 Protein Design Labs 56 Guidant 40 Teva 159 Apotex 77 Boston Scientic 55 Pliva 40 Proctor & Gamble 157 Covance 77 Fluor Daniel 55 Takeda 40

* BPA June 2005 Statement ** Pharmaceutical Manufacturing *** Pharmaceutical Manufacturing, Bio Pharmaceutical Mfg., Nutritional/Nutraceutical Products Mfg. **** Pharmaceutical Manufacturing, Nutraceutical Manufacturing ^ Publisher’s Own Data

The PharmTech Reader

Pharmaceutical Technology readers are industry professionals that purchase and recommend the purchase of products for their company. PharmTech is the only magazine in the industry that covers multiple topics relating to pharma and biopharm development and manufacturing. We’ve broken out readership stats to show a detailed picture of the categories we serve and the issues that target that specific audience. Whether you look at our readership from an overall perspective or a categorical one, you’ll see that readers rely 71.5% consider on PharmTech to keep them abreast of the changing technology Pharmaceutical Technology and help them make purchase decisions. to be the number ONE source for information on new products and services.* PT SUBSCRIBERS APPROVE OR RECOMMEND THE PURCHASE OF PRODUCTS AND SERVICES FOR THEIR COMPANIES*

Laboratory Equipment 74% Chemicals, Excipients and APIs 65% On average, readers spend Outsourced Services 64% 1.6 hours Manufacturing & Processing Equipment 62% with their issue and have Compliance & Validation 60% been reading Pharmaceutical Drug Delivery Technology 50% Technology for 6.5 years Packaging 46% Aseptic/Sterile Processing 38%

Readers pass their A VERY SMALL PERCENTAGE OF PHARM TECH READERS issue along to an additional READ OTHER PUBLICATIONS REGULARLY* 1.4 colleagues, extending the total audience to more than Pharmaceutical Manufacturing 43% Pharmaceutical Processing 42% 92,600 readers Drug Delivery Technology 31% Contract Pharma 28% American Pharmaceutical Review 28% Tablets & Capsules 24% The majority of readers American Pharmaceutical Outsourcing 14% work for conventional/biotech PFQ 14% pharma manufacturers with an average of $5.8 billion in annual revenue and annual 94% HAVE TAKEN ACTION IN RESPONSE TO ADS/EDITORIAL investments of 1.1 billion in R&D.*

Visited a company’s Web site for more information 74% Discussed with someone else in the company 72% Passed along a tearsheet, photocopy, or issue 58% Sought additional information about products or services 56% Recommended the purchase of a product or service 36% Purchased products or services 25%

Source: 2004 Readership Study Conducted by Proximity Marketing *2005 Market Study Conducted by The Wayman Group

The Leader in Manufacturing/ Processing Equipment

of PharmTech readers indicated they are 62% involved in purchasing Manufacturing/Processing Equipment for their company.

MANUFACTURING/PROCESSING EQUIPMENT PROFILE OF THE PHARMTECH PURCHASED BY PHARMTECH READERS* MANUFACTURING/ PROCESSING EQUIPMENT BUYER

Filtration/Separation 50% PURCHASE POWER Mixing/Blending/Drying 49% Tablet Presses 44% $ They plan to spend an average of 6.4 Coating 44% million on manufacturing and processing Pumps 42% equipment over the next 2 years.* PAT/Process Control 41% $ 84% are involved in making the decision Fluid-Bed 38% Material Handling 37% to purchase for their companies. QA/QC 35% $ On average, their companies invest Capsule Filling Machinery 29% $319.5 million in R&D. Bioprocessing 27% Lyophilizers/Freeze Dryers 23% $ They work for companies with average Soft Gel MFG 7% annual revenue of $2.0 billion.

INFORMATION SOURCES MARKET FACTS* $ 95% consider PharmTech to be an In an independent market study conducted by The Wayman Group, on average, conventional and biotech manufacturing companies plan authoritative source. to spend $8.2 million on Manufacturing/Processing Equipment $ If they had to choose one publication as compared to 4.55 million in 2003, a 45% increase! their single source of information, 82% would choose Pharmaceutical Technology. 74.4% Increase $ 80% consider PharmTech to be the market leader in providing information about manufacturing and development No Change 15.4% technologies. $ 52% do NOT receive Pharmaceutical Decrease 10.3% Processing and only 17% read it regularly. $ 57% do NOT receive American Pharmaceutical Review and only 18% read it regularly. TARGETED EDITORIAL OPPORTUNITIES $ 52% do NOT receive Pharmaceutical Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Manufacturing and only 21% read it regularly. Manufacturing : S S : $ 62% do NOT receive Tablets & Capsules Equipment & Supplies and only 11% read it regularly. Filtration/Separation : S Biotech/ READER AFFINITY Large Molecules : : $ 97% have taken action in response Aseptic Processing S to ads/articles. FDA/Standards/ Policy : : : : : : S : : : : $ They have been PharmTech readers for an average of 7.2 years and spend Career Management S 1.8 hours reading each issue.

S = Special Report $ 82% read 3 or 4 of 4 issues of : = Focus Pharmaceutical Technology. = Coverage

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group The Leader in Outsourced Services

of PharmTech readers indicated they are 64% involved in purchasing Outsourced Services for their company.

OUTSOURCED SERVICES PURCHASED PROFILE OF THE PHARMTECH BY PHARMTECH READERS* OUTSOURCED SERVICES BUYER

PURCHASE POWER Consulting 50% $ They plan to spend an average of 4 million Compliance & Validation 48% on outsourced services over the next Manufacturing 46% 2 years.* Labs 44% $ 84% are involved in making the decision to Research 42% purchase for their companies. Packaging 35% $ On average, their companies invest $310.1 million in R&D. $ They work for companies with average annual revenue of $1.9 billion. MARKET FACTS*

In an independent market study conducted by The Wayman Group, INFORMATION SOURCES on average, conventional and biotech manufacturing companies plan $ 93% consider PharmTech to be an to spend $4.53 million on Outsourced Services compared to authoritative source. $3.45 million in 2003, a 24% increase! $ If they had to choose one publication as their single source of information, 81% 59.4% Increase would choose Pharmaceutical Technology. $ 77% consider PharmTech to be the market leader in providing information about manufacturing and development technologies. No Change 27.5% Decrease 13% $ 52% do NOT receive Contract Pharma and only 18% read it regularly. $ 62% do NOT receive American Pharmaceutical Outsourcing and only 9% read it regularly. $ 52% do NOT receive Drug Delivery TARGETED EDITORIAL OPPORTUNITIES Technology and only 19% read it regularly. Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec $ 66% do NOT receive Pharmaceutical

Outsourced Formulation and only 8% read it regularly. Services S : : : : : : : : : : : Packaging/ Labeling/Bar Coding : : : : : : READER AFFINITY Career Management S $ 96% have taken action in response to ads/articles. S = Special Report : = Focus $ They have been PharmTech readers for an = Coverage average of 6.8 years and spend 1.8 hours reading each issue. $ 80% read 3 or 4 of 4 issues of Pharmaceutical Technology.

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group The Leader in Compliance & Validation

of PharmTech readers indicated they are involved 60% in purchasing Compliance & Validation Software Products and Services for their company.

COMPLIANCE & VALIDATION SOFTWARE PRODUCTS AND SERVICES PROFILE OF THE PHARMTECH PURCHASED BY PHARMTECH READERS* COMPLIANCE & VALIDATION BUYER

PURCHASE POWER 21 CFR Part 11 Compliance 61% $ They plan to spend an average of .50 million QA Validation 54% on compliance and validation products and Consulting 52% services over the next 2 years.* Document Management 46% $ 83% are involved in making the decision to Process Control/MES 28% purchase for their companies. ERP 9% $ On average, their companies invest $327.6 million in R&D. $ They work for companies with average annual revenue of $2.1 billion. MARKET FACTS*

In an independent market study conducted by The Wayman Group, on average, conventional and biotech manufacturing companies plan INFORMATION SOURCES to spend $.52 million on Compliance and Validation and the majority $ 95% consider PharmTech to be an plan to increase spending! authoritative source. $ If they had to choose one publication as 60% Increase their single source of information, 79% would choose Pharmaceutical Technology. $ 77% consider PharmTech to be the market leader in providing information about manufacturing and development technologies. No Change 35% Decrease 5% $ 57% do NOT receive American Pharmaceutical Review and only 16% read it regularly. $ 53% do NOT receive Contract Pharma and only 16% read it regularly. TARGETED EDITORIAL OPPORTUNITIES $ 57% do NOT receive Pharmaceutical Processing and only 15% read it regularly. Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Validation/ : S : : Compliance READER AFFINITY Analytical Testing S : : : : : : $ 95% have taken action in response FDA/Standards/ to ads/articles. Policy : : : : : : : S : : : : $ They have been PharmTech readers for PAT : an average of 7 years and spend 1.8 hours IT/Automation/ reading each issue. 21 CFR 11 : $ 80% read 3 or 4 of 4 issues of Career Management S Pharmaceutical Technology. S = Special Report : = Focus = Coverage

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group The Leader in Chemicals, Excipients and APIs

of PharmTech readers indicated they are 65% involved in purchasing Chemicals, Excipients and APIs for their company.

CHEMICALS, EXCIPIENTS AND APIs PROFILE OF THE PHARMTECH PURCHASED BY PHARMTECH READERS* CHEMICALS, EXCIPIENTS AND APIs BUYER

Raw Materials 76% PURCHASE POWER Excipients 65% $ They plan to spend an average of 4.4 million APIs 57% on chemicals, excipients and APIs over the Bulk Chemicals 56% next 2 years.* $ 82% are involved in making the decision to purchase for their companies.

MARKET FACTS* $ On average, their companies invest $326.5 million in R&D. In an independent market study conducted by The Wayman Group, on average, conventional and biotech manufacturing companies plan to $ They work for companies with average spend $6.48 million on Chemicals, Excipients and APIs and the annual revenue of $2.1 billion. majority plan to increase spending!

INFORMATION SOURCES 56.3% Increase $ 95% consider PharmTech to be an authoritative source. $ If they had to choose one publication as their single source of information, 77% No Change 31.3% would choose Pharmaceutical Technology. Decrease 12.5% $ 72% consider PharmTech to be the market leader in providing information about manufacturing and development technologies. $ 49% do NOT receive Drug Delivery Technology and only 21% read it regularly. TARGETED EDITORIAL OPPORTUNITIES $ 54% do NOT receive Pharmaceutical Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Formulation and only 12% read it regularly. $ 56% do NOT receive American Excipients : : : S S : Pharmaceutical Review and only 20% read Formulation : : : S S it regularly. Active Ingredient/ $ 65% do NOT receive Tablets & Capsules and API Manufacturing S only 10% read it regularly. Solid Dosage Forms : : S S

Career Management S READER AFFINITY $ S = Special Report 97% have taken action in response : = Focus to ads/articles. = Coverage $ They have been PharmTech readers for an average of 7 years and spend 1.8 hours reading each issue. $ 80% read 3 or 4 of 4 issues of Pharmaceutical Technology.

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group The Leader in Drug Delivery Technology

of PharmTech readers indicated 50% they are involved in purchasing Drug Delivery Technology products and services for their company.

DRUG DELIVERY TECHNOLOGIES PROFILE OF THE PHARMTECH DRUG PURCHASED BY PHARMTECH READERS* DELIVERY TECHNOLOGY BUYER

PURCHASE POWER Solid Dosage 58% $ They plan to spend an average of 3.3 million Capsules, Hard & Soft 41% on drug delivery products and services over Parenterals 37% the next 2 years.* Syringes 28% $ 80% are involved in making the decision to Transdermal Patches/Components 23% purchase for their companies. Nasal 20% $ On average, their companies invest Aerosols 15% $390.3 million in R&D. Inhalation 15% $ They work for companies with average annual revenue of $2.3 billion.

MARKET FACTS* INFORMATION SOURCES In an independent market study conducted by The Wayman Group, on average, conventional and biotech manufacturing companies plan $ 95% consider PharmTech to be an to spend $4.12 million on Drug Delivery Technology compared to authoritative source. $3.05 million in 2003, a 26% increase! $ If they had to choose one publication as their single source of information, 85% would choose Pharmaceutical Technology. 60.0% Increase $ 81% consider PharmTech to be the market leader in providing information about manufacturing and development technologies. $ 43% do NOT receive Drug Delivery Decrease 10.8% No Change 29.2% Technology and only 26% read it regularly. $ 59% do NOT receive Tablets & Capsules and only 14% read it regularly. $ 57% do NOT receive American Pharmaceutical Review and only 20% read TARGETED EDITORIAL OPPORTUNITIES it regularly.

Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

Drug Delivery & READER AFFINITY Technology Systems : : S : $ 98% have taken action in response Excipients S S : : : : to ads/articles. Formulation : : : S S $ They have been PharmTech readers for an average of 8 years and spend 2 hours Solid Dosage Forms S S : : reading each issue. Aseptic Processing S $ 79% read 3 or 4 of 4 issues of Pharmaceutical Technology. Career Management S

S = Special Report : = Focus = Coverage

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group The Leader in Aseptic/Sterile Processing

of PharmTech readers indicated 38% they are involved in purchasing Aseptic/Sterile Processing products for their company.

ASEPTIC/STERILE PROCESSING PRODUCTS AND SERVICES PROFILE OF THE PHARMTECH PURCHASED BY PHARMTECH READERS* ASEPTIC/STERILE PROCESSING BUYER

PURCHASE POWER Cleanroom Equipment 74% $ They plan to spend an average of 4.9 million Sanitizing/Cleaning Agents 41% on aseptic/sterile processing equipment and Barrier/Isolation Systems 41% services over the next 2 years.* Gloveboxes 39% $ 83% are involved in making the decision to Cleanroom Garments, Gloves, Supplies 37% purchase for their companies. HVAC Equipment/Filters 37% $ On average, their companies invest Terminal Sterilization Equipment 35% $329.9 million in R&D. Particle/Microbe Counters 34% $ They work for companies with average Entry Systems 25% annual revenue of $2.0 billion.

INFORMATION SOURCES $ 93% consider PharmTech to be an MARKET FACTS* authoritative source. In an independent market study conducted by The Wayman Group, $ If they had to choose one publication as on average, conventional and biotech manufacturing companies plan their single source of information, 77% to spend $5.33 million on Aseptic/Sterile Processing compared would choose Pharmaceutical Technology. to $3.24 million in 2003, a 39% increase! $ 76% consider PharmTech to be the market leader in providing information about 63.2 % Increase manufacturing and development technologies. $ 52% do NOT receive Pharmaceutical Processing and only 17% read it regularly. No Change 31.5% $ 57% do NOT receive American Pharmaceutical Review and only 18% read Decrease 5.3 % it regularly. $ 53% do NOT receive Contract Pharma and only 18% read it regularly. $ 56% do NOT receive Drug Delivery TARGETED EDITORIAL OPPORTUNITIES Technology and only 17% read it regularly.

Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

Aseptic READER AFFINITY Processing S $ They have been PharmTech readers for Biotech/Large Molecules : : an average of 6.8 years and spend 1.8 hours reading each issue. Career Management S $ 96% have taken action in response to S = Special Report ads/articles. : = Focus $ 80% read 3 or 4 of 4 issues of = Coverage Pharmaceutical Technology.

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group

The Leader in Laboratory Equipment

of PharmTech readers indicated they are 74% involved in purchasing Laboratory Equipment for their company.

LAB EQUIPMENT PURCHASED PROFILE OF THE PHARMTECH BY PHARMTECH READERS* LAB EQUIPMENT BUYER

PURCHASE POWER Balances & Scales 76% $ They plan to spend an average of 2.6 million Chromatography 63% on laboratory products and services over the Temperture Instrumentation/ 57% next 2 years.* Thermometers $ 81% are involved in making the decision to Spectrometers 57% purchase for their company. Tubing/Piping/Glassware 56% $ On average, their companies invest 55% Centrifuges/Stirrers $307.7 million in R&D. Sample Preparation Instrumentation 44% $ They work for companies with average Viscometers 34% annual revenue of $1.8 billion

INFORMATION SOURCES $ 94% consider PharmTech to be an MARKET FACTS* authoritative source. In an independent market study conducted by The Wayman Group, $ If they had to choose one publication as on average, conventional and biotech manufacturing companies plan to their single source of information, 77% spend $2.81 million on Laboratory Equipment compared to $1.6 million would choose Pharmaceutical Technology. in 2003, a 43% increase! $ 75% consider PharmTech to be the market leader in providing information about 58.2 % Increase manufacturing and development technologies. $ 58% do NOT receive American Pharmaceutical Review and only 17% read it regularly. No Change 26.6% $ 52% do NOT receive Contract Pharma and only 16% read it regularly. Decrease 15.2% $ 65% do NOT receive Pharmaceutical Formulation and only 9% read it regularly. $ 55% do NOT receive Pharmaceutical TARGETED EDITORIAL OPPORTUNITIES Processing and only 14% read it regularly.

Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec READER AFFINITY Filtration/Separation : S $ 96% have taken action in response to Analytical Testing S : : : : : : ads/articles.

FDA/Standards/Policy : : : : : : : S : : : : $ They have been PharmTech readers for an average of 6.3 years and spend Career Management S 1.7 hours reading each issue.

S = Special Report $ 77% read 3 or 4 of 4 issues of : = Focus Pharmaceutical Technology. = Coverage

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group The Leader in Packaging

of PharmTech readers indicated they are 46% involved in purchasing Packaging products, supplies and equipment for their company.

PACKAGING PRODUCTS PURCHASED PROFILE OF THE PHARMTECH BY PHARMTECH READERS* PACKAGING BUYER

PURCHASE POWER Packaging Equipment 69% $ They plan to spend an average of 4.9 million Bottle Filling/Capping/Sealing 50% on packaging over the next 2 years.* Liquid Filling Equipment 47% $ 85% are involved in making the decision to Machine Vision Inspection 31% purchase for their companies. Ampule & Vial Filling/Sealing 30% $ On average, their companies invest $316.5 million in R&D. $ They work for companies with average annual revenue of $2.0 billion. MARKET FACTS*

In an independent market study conducted by The Wayman Group, INFORMATION SOURCES on average, conventional and biotech manufacturing companies plan $ 96% consider PharmTech to be an to spend $5.59 million on Packaging compared to $2.38 million authoritative source. in 2003, a 57% increase! $ If they had to choose one publication as their single source of information, 82% 59.6% Increase would choose Pharmaceutical Technology. $ 76% consider PharmTech to be the market leader in providing information about manufacturing and development technologies. No Change 29.8% Decrease 10.6% $ 52% do NOT receive Pharmaceutical Processing and only 17% read it regularly. $ 45% do NOT receive Contract Pharma and only 19% read it regularly.

TARGETED EDITORIAL OPPORTUNITIES READER AFFINITY

Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec $ 96% have taken action in response to ads/articles. Packaging/Labeling/ : : : : : : Bar Coding $ They have been PharmTech readers for Outsourcing Services S : : : : : : : : : : : an average of 8.1 years and spend 2 hours reading each issue. Career Management S $ 81% read 3 or 4 of 4 issues of S = Special Report Pharmaceutical Technology. : = Focus = Coverage

Sources: 2004 Readership Study Conducted by Proximity Marketing * 2005 Market Study Conducted by The Wayman Group

Editorial Overview

INDUSTRY-LEADING EDITORIAL Douglas McCormick Laura Bush Maribel Rios Editor in Chief Managing Editor Senior Editor With regard to content, Pharmaceutical Technology clearly dominates the industry. Every month PharmTech reports on technological aspects that affect the pharma/biopharm manufacturing industry from equipment and ingredients to marketing and distribution. Kaylynn Chiarello Melissa Denneau Our editorial staff members are experts in their field. They know Associate Editor Art Director the current state of affairs, forecast changes and are dedicated to delivering trusted, peer-written and reviewed content that helps science progress by keeping scientists and managers informed of the latest technological advances. George Koroneos Eric Greb Assistant Editor Assistant Editor CONTRIBUTING INDUSTRY EXPERTS AND COLUMNS

Outsourcing Outlook Packaging Forum Published Monthly Published March, May, June, August, In his monthly column, outsourcing expert Jim Miller, September, & October President of PharmSource Information Services and Publisher Pharmaceutical packaging expert Hallie Forcino publishes of Bio/Pharmaceutical Outsourcing Report, offers timely columns on packaging components and systems, labeling, insights into trends and challenges facing contract service container — closure systems, stability and packaging, and other providers and users. timely topics. Additional contributed technical articles deal with labeling, temperature-sensitive materials, regulation, USP/IPEC Columns and related concerns. Exclusive insider observation and analysis from two critical industry organizations: USP and IPEC. Contributed columns Washington Report from senior USP and IPEC representatives appear regularly Published Monthly throughout the year in Pharmaceutical Technology. Washington Editor, Jill Wechsler regularly meets with FDA and USP officials, members of Congress, Agent in Place and industry organization representatives to learn about Pharmaceutical Technology's new monthly “Agent-in-Place” and report on key developments and the emerging trends column distills real-world cautionary tales from the files that shape the industry. of a senior compliance officer: clueless operators, oblivious management, awkward lapses of judgment and Guest Editorial Murphy's Law in action. But no names, please. Pharmaceutical Technology’s “Viewpoint” column gives industry leaders the last word (opposite the inside back cover) to air their special insights on emerging issues. ANNUAL RESOURCE ISSUES

2006 Corporate Capabilities Published in December

Showcase your company in Pharmaceutical Technology’s 2006 Corporate Capabilities issue. Your advertorial page will include a company description, markets served, technologies, technical services, facilities, major products and two 4/color photographs. Corporate Capabilities will be distributed at all industry shows attended in 2007.

Buyers Guide Closes May

The Buyers’ Guide is essential to PharmTech readers: 65% of readers have no name in mind when using the Buyers’ Guide, 85% have contacted a company for information on one or more products seen and of that group 81% have purchased a product or service after contacting a company.* This indispensable resource is distributed to Pharmaceutical Technology’s entire BPA–qualified circulation and to thousands of show attendees who save the issue for an entire year. The Buyers’ Guide will be distributed at all industry shows attended from 6/06 through 5/07.

Outsourcing Resources Published in August

In conjunction with Jim Miller of PharmSource, this special issue of Pharmaceutical Technology delivers exclusive new research every year about the latest trends in the Outsourced Services market, information about future plans to purchase Outsourced Services, and a mix of articles and features on the issues most important to your market. Outsourcing Resources will be distributed at all industry shows attended from 9/06 through 8/07.

* 2004 Readership Study Conducted by Proximity Research Editorial Calendar 2006

ISSUE SPECIAL REPORTS EDITORIAL FOCUS ADDITIONAL COVERAGE

JANUARY •Outsourcing Services Manufacturing Equipment & Supplies • API • Excipients • Formulation • Analytical Testing • FDA/Regulation • Standards • Ad Close: December 2 •Custom Manufacturing IT/Automation • Process Control/PAT • 21 CFR 11 • Validation/Compliance • Drug Delivery Technology & Controlled Release • Outlook Coating & Coloring • Solid Dosage Manufacturing • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/ Cleanrooms • Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography

FEBRUARY •Analytical Technology Outsourced Services • Validation/Compliance • Separation/Filtration/Chromatography • FDA/Regulation • Standards • Ad Close: January 3 •SOCMA Forum IT/Automation • Process Control/PAT • 21 CFR 11 • Active Pharmaceutical Ingredients • Drug Delivery Technology & Controlled Release • Coating & Coloring • Excipients • Formulation • Solid Dosage Manufacturing • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/Cleanrooms • Biotechnology/Large-Molecule Processes • Manufacturing Equipment & Supplies

MARCH •Manufacturing Analytical Testing • Excipients • Formulation • Solid Dosage Manufacturing • FDA/Regulation • Standards • IT/Automation Ad Close: February 1 Equipment • Process Control/PAT • 21 CFR 11 • Active Pharmaceutical Ingredients • Validation/Compliance • Drug Delivery Technology & •Investment Strategies: Controlled Release • Coating & Coloring • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Aseptic Large Custom Players Processing/Lyophilization/Cleanrooms • Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

APRIL •Aseptic Processing Biotechnology/Large-Molecule Processes • Controlled Release • Coating & Coloring • Excipients • Formulation • Analytical Ad Close: March 1 •Chiral Chemistry Testing • FDA/Regulation • Standards • IT/Automation • Process Control/PAT • 21 CFR 11 • Validation/Compliance • Drug Delivery Technology • Solid Dosage Manufacturing • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/ Lyophilization/Cleanrooms • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

MAY •Process Separation/ Biotechnology/Large-Molecule Processes • Analytical Testing • FDA/Regulation • Standards • IT/Automation • Process Ad Close: April 3 Chromatography/ Control/PAT • 21 CFR 11 • Active Pharmaceutical Ingredients • Validation/Compliance • Drug Delivery Technology & Controlled Filtration Release • Coating & Coloring • Excipients • Formulation • Solid Dosage Manufacturing • Outsourced Services • Packaging • •Sourcing:India & China Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/Cleanrooms • Manufacturing Equipment & Supplies

2006 The most comprehensive guide to products, services, and industry information published for the pharmaceutical and BUYERS’ GUIDE biopharmaceutical industry. Ad Close: May

JUNE •Solid Dosage Analytical Testing • Validation/Compliance • FDA/Regulation • Standards • IT/Automation • Process Control/PAT • Ad Close: May 1 Processing 21 CFR 11 • Active Pharmaceutical Ingredients • Drug Delivery Technology & Controlled Release • Coating & Coloring • •Peptides & Biologics Excipients • Formulation • Solid Dosage Manufacturing • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Manufacturing Aseptic Processing/Lyophilization/Cleanrooms • Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

JULY •U.S. Pharma Industry Coating & Coloring • Excipients • Formulation • Solid Dosage Manufacturing • Analytical Testing • FDA/Regulation • Standards • Ad Close: June 1 Rankings Spotlight IT/Automation • Process Control/PAT • 21 CFR 11 • Active Pharmaceutical Ingredients • Validation/Compliance • Outsourced Services • •Rising Players in Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/Cleanrooms • Biotechnology/Large-Molecule Processes Global Fine Chemicals • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

AUGUST •FDA International Validation/Compliance • Analytical Testing • Standards • IT/Automation • Process Control/PAT • 21 CFR 11 • Active Pharmaceutical Ad Close: July 3 Regulatory Wrapup Ingredients • Drug Delivery Technology & Controlled Release • Coating & Coloring • Excipients • Formulation • Solid Dosage •Chiral Chemistry Manufacturing • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/Cleanrooms • •CPhI Preview Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

SEPTEMBER •Excipients & Tableting Standards • Analytical Testing • Validation/Compliance • Process Control/PAT • FDA/Regulation • IT/Automation • 21 CFR 11 • Ad Close: August 1 •High Potency Actives Active Pharmaceutical Ingredients • Drug Delivery Technology & Controlled Release • Coating & Coloring • Formulation • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/Cleanrooms • Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

OCTOBER •Formulation Analytical Testing • Drug Delivery Technology & Controlled Release • FDA/Regulation • Standards • IT/Automation • Process Ad Close: September 1 •APIs, Fine Chemicals Control/PAT • 21 CFR 11 • Validation/Compliance • Coating & Coloring • Excipients • Solid Dosage Manufacturing • Outsourced & Intermediates Services • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/Cleanrooms • Biotechnology/Large-Molecule •AAPS & CPhI Processes • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies Show Issue

NOVEMBER •API Manufacturing Manufacturing Equipment & Supplies • Validation/Compliance • Analytical Testing • FDA/Regulation • Standards • IT/Automation Ad Close: October 2 •Biosciences • Process Control/PAT • 21 CFR 11 • Drug Delivery Technology & Controlled Release • Coating & Coloring • Excipients • Formulation • •CPhI Review Solid Dosage Manufacturing • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/ Cleanrooms • Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography

DECEMBER •Management & Career: Excipients • Analytical Testing • FDA/Regulation • Standards, IT/Automation • Process Control/PAT • 21 CFR 11 • Active Pharmaceutical Ad Close: November 1 Salary Survey Ingredients • Validation/Compliance • Drug Delivery Technology & Controlled Release • Coating & Coloring • Excipients • Formulation • •Catalysis in Solid Dosage Manufacturing • Outsourced Services • Packaging • Labeling/Barcoding/RFID • Aseptic Processing/Lyophilization/ Pharma Manufacture Cleanrooms • Biotechnology/Large-Molecule Processes • Separation/Filtration/Chromatography • Manufacturing Equipment & Supplies

SPECIAL ISSUES BONUS DISTRIBUTION VALUE ADDED OPPORTUNITIES

IVT Conferences: Aseptic Processing/Sterile Processes Free 1/3 page Interphex PR Exhibitor Profile outlining Packaging & Labeling your company’s products and services Interphex Puerto Rico : San Juan, Puerto Rico Free 4/C product/literature release

Primer Series: Analytical Methods NEW PittCon: Orlando, FL Interphex Bonus Marketing Package & Process Control IFPAC: Arlington, VA Advertise in Feb/Mar or Mar/Apr and receive: • Advertise in primer and receive Informex: Orlando, FL Free product/literature release online with hyperlink up to 50 copies Free Bonus Buyer Intention Leads from 2 Surveys Free 4/C product/literature release in print edition Interphex: New York, NY Free lamination of your ad IVT Conferences : Project Management for R&D Advertise in Feb, Mar and Apr and receive all of the above PLUS: FDA Inspections Free duplication of your ad in the Interphex Exhibitor Show Guide distributed to all Interphex attendees (in sponsorship bags, at registration, and our booth) Free duplication of your ad on E-Zine BIO Chicago, IL Discounted email blast PDA: Annual Meeting Anaheim, CA Free 4/C product/literature release in Show Guide ExcipientFest: San Juan, Puerto Rico Generation Next — limited sponsorship opportunities IVT Conference : Computer Validation Ask about our on-line Show Daily sponsorships

Aseptic Processing Int’l Powder & Bulk Solids: Rosemont, IL Free Ad Performance Study — independent survey of Pharm Tech IVT Conferences : Cleaning Validation readers will measure the effectiveness of your ad Stability Testing (special offer for full page advertisers) Active Pharmaceutical Ingredients Free 4/C product/literature release

2006 Buyers Guide Buyers Guide will be distributed at all industry shows Free logo attended from 6/06 through 5/07 Free red box listings Free bolded listings Free on-line listings with hyperlinks

Primer Series: AAPS: National BioTech: Boston, MA Summer Advertising Package: cGMP Compliance DIA: Annual Meeting Philadelphia, PA Free product/literature release online with hyperlink • Advertise in primer and receive IVT Conferences : Process Analytical Technology (PAT) See your sales consultant for details NEW up to 50 copies Validation Workshops Free 4/C product/literature release

Controlled Release Society: Annual Meeting Summer Advertising Package: Vienna, Austria Free product/literature release online with hyperlink See your sales consultant for details Free 4/C product/literature release

Outsourcing Resources IVT Conferences : Computer Validation Free profile page opportunity (special offer for full page advertisers) Risk Management Free 4/C product/literature release August Outsourcing: Free highlighted Provider Services Company listing

ACS: Fall San Francisco, CA Free on-line White Paper IVT Conference : Lab Compliance Free 4/C product/literature release

NEW Primer Series: AAPS: Annual Meeting San Antonio, TX AAPS Issue Company Profile: Excipient Performance CPhI/ICSE Paris, France Free 1/3 page vertical, 4/C profile outlining your • Advertise in primer and receive IVT Conferences:Active Pharmaceutical Ingredients company’s products and services up to 50 copies Annual Meeting Validation Week Free 4/C product/literature release Method Validation Ask about our on-line Show Daily sponsorships

IT Solutions/Automation/21 CFR 11 IVT Conferences : Electronic Records Management Free Ad Performance Study — independent survey of Pharm Tech Microbiology Compliance readers will measure the effectiveness of your ad Project Management (special offer for full page advertisers) for Manufacturing Free 4/C product/literature release

Corporate Capabilities will be distributed at all industry December Corporate Capabilities: shows attended in 2007 Free profile for qualified advertisers Online Bonus Package — see sales consultant for details Free 4/C product/literature release PharmTech 2006 Rates

PHARMACEUTICAL TECHNOLOGY 2006 BLACK & WHITE GROSS RATES — US DOLLARS

1X 3X 6X 1 2X 1 8X 24X

Full Page 8,715 8,350 7,990 7,800 7,535 7,265

2/3 Page 7,285 7,055 6,825 6,585 6,355 6,125

1/2 Page 6,300 6,085 5,880 5,670 5,465 5,260

1/3 Page 4,520 4,360 4,190 4,025 3,800 3,705

1/4 Page 3,530 3,390 3,250 3,115 2,905 2,840

PHARMACEUTICAL TECHNOLOGY 2006 FULL COLOR GROSS RATES — US DOLLARS

1X 3X 6X 12 X 18 X 24 X

Full Page 10,225 10,080 9,895 9,705 9,440 9,170

2/3 Page 9,190 8,960 8,730 8,490 8,260 8,030

1/2 Page 8,205 7,990 7,785 7,575 7, 370 7,165

1/3 Page 6,425 6,265 6,095 5,930 5,775 5,610

1/4 Page 5,435 5,295 5,155 5,020 4,880 4,745

AD DIMENSIONS WIDTH DEPTH Standard 900 Cover 2 785 Full Page 6 3/4” 9 1/2” Matched 1,085 Cover 3 690 2/3 Page 4 1/2” 9 1/2” Metallic 1,545 Cover 4 1,120 1/2 Page Island 4 1/2” 7” Four-Color 1,905 Preferred Pos. 580 1/2 Page Horizontal 6 3/4” 4 5/8”

1/2 Page Vertical 3 3/8” 9 1/2” DIGITAL AD REQUIREMENTS: 1/3 Page Square 4 1/2” 4 5/8” Digital data is required for all ad submissions. Preferred format is PDF/X-1. Acceptable format is a hi-res PDF. Files should be press 1/3 Page Vertical 2 1/8” 9 1/2” optimized, converted to CMYK, and have all fonts embedded. Pharmaceutical Technology will be relieved of all responsibility 1/4 Page 3 3/8” 4 5/8” for any form of compensation if an ad is supplied in non-preferred or non-acceptable formats, such as native application files. WID TH DEP TH Non-preferred or non-acceptable formats will be charged a $150 processing fee. We cannot guarantee the accuracy of Trim Size 7 3/4” 10 1/2” reproduction from any ads supplied in non-preferred or non-acceptable formats. For detailed instructions of preferred Bleed 8” 10 3/4” formats, contact the production manager or download digital ad Live Matter 7” 9 3/4” specifications from www.advanstar.com/adspec/. Spread Size 14 1/2” 9 1/2” Pharmaceutical Technology will not supply a faxed or soft proof on client-supplied files. We assume due diligence has been taken Bleed (Spread) 15 3/4” 10 3/4” by the client or by their agency to preflight and proof all advertisements prior to submission. PRIMERS WIDTH DEPTH Files may be submitted on CD-ROM. Files may also be submitted to our FTP site. Please contact the production manager for Trim Size 5 1/4” 8 3/8” instructions. Bleed 5 1/2” 8 5/8” To insure that your ad is reproduced correctly, a SWOP-certified color proof that has been made from the same file that you supply Live Matter 4 1/4” 7 3/8” to us must be provided. We cannot guarantee the accuracy of reproduction of your ad without a SWOP proof. No make-goods Spread Size 10 1/2” 8 3/8” will be issued on ads that run without a SWOP proof. Bleed (Spread) 11” 8 5/8”

Send all materials and ad insertion orders to: Kim Brown, Pharmaceutical Technology, 131 West 1st Street, Duluth, MN 55802-2065 Tel: 218-723-9147 Fax: 218-723-9223 Email: [email protected]

PharmTech Special Issues

In addition to our monthly issues, Pharmaceutical Technology provides annual resources and specialty issues showcasing specific areas of interest to readers. The additional five supplements and three primers we publish every year offer unique topic-focused advertising opportunities.

ASEPTIC PROCESSING Published in May Pharmaceutical Technology’s 2006 Aseptic Processing supplement will cover technology topics and issues of particular importance to this major segment of the pharmaceutical industry. Subjects presented will include the latest on media fill acceptance criteria, barrier/isolation technology, sterile filtration, apparel, cleanroom design, environmental monitoring, process control validation and documentation.

BUYERS GUIDE Closes May The Buyers’ Guide is essential to PharmTech readers: 65% of readers have no name in mind when using the Buyers’ Guide, 85% have contacted a company for information on one or more products seen and of that group 81% have purchased a product or service after contacting a company.* This indispensable resource is distributed to Pharmaceutical Technology’s entire BPA–qualified circulation and to thousands of show attendees who save the issue for an entire year.

OUTSOURCING RESOURCES Published in August In conjunction with Jim Miller of PharmSource, this special issue of Pharmaceutical Technology delivers exclusive new research every year about the latest trends in the Outsourced Services market, information about future plans to purchase Outsourced Services, and a mix of articles and features on the issues most important to your market.

IT SOLUTIONS/A UTOMATION/2 1 CFR 11 Published in November In this specially focused annual issue, Pharmaceutical Technology updates readers on the rapidly evolving technologies of enterprise-wide networking and data storage; manufacturing execution and information management software solutions and explains the link between these technologies to drug development and manufacturing; quality control and product tracking; and documentation and regulatory compliance operations.

2006 CORPORATE CAPABILITIES Published in December Showcase your company in Pharmaceutical Technology’s 2006 Corporate Capabilities issue. Your advertorial page will include a company description, markets served, technologies, technical services, facilities, major products and two 4/color photographs. Ask your sales consultant about how you could qualify for a FREE company profile.

THE PRIMER SERIES Published in February: Analytical Methods & Process Control Published in June: cGMP Compliance Published in October: Excipient Performance Pharmaceutical Technology’s highly-focused Technology Primers serve to quickly update and educate industry professionals on the latest, most significant new developments in critical technology areas. Presented in clear, acronym-explained language, each primer is designed to provide both a broad introduction to, as well as timely information and discussion of, cutting edge technology in each segment. TheTechnology Primers have become an essential resource, distributed and frequently referenced throughout pharmaceutical development and manufacturing organizations.

* 2004 Readership Study Conducted by Proximity Research

Introducing: PharmTech Asia

THE INDUSTRY’S AUTHORITATIVE SOURCE EXPANDS TO ASIAN MARKETS

As R&D investments in the Asian Pacific region continue to climb—$937 Billion* in 2003—so does the need for reliable information about all aspects of the development and manufacture of drugs. Concurrently, marketers will look for a trusted channel to these potential buyers. Pharmaceutical Technology, the industry’s most reliable source for information about North American markets, will become the information conduit for buyers and sellers in Asia Pacific. With a planned launch of Pharmaceutical Technology Asia will deliver expert, technical, peer-reviewed content to a readership of 7,500** key prospects across the R&D/QA/QC/ Production/Manufacturing/Engineering functions in countries in the Asian Pacific region including:

CANADA Hudson Bay

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GREENLAND Chukchi Sea Bering Sea ICELAND ARCTIC OCEAN Greenland Sea ATLANTIC OCEAN Norwegian Sea Japan Leptev Sea

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Atlas Mts. AUSTRIA Lena BELARUS SLOVAKIA SLOVENIA Angara CROATIA Vol HUNGARY ga Ural Mts.

UKRAINE Dnieper Hong Kong MAURITANIA BOSNIA L. Baykal ROMANIA ITALY YUGOSLAVIA MOLDOVA D a TUNISIA MACEDONIA nu JAPAN ALBANIA be Sea of ALGERIA MALTA BULGARIA Japan M GREECE e NORTH MALI KOREA d Black Sea Irtysh MONGOLIA i t t SOUTH e Caucasus KAZAKHSTAN r Niger e KOREA PACIFIC r s Yellow S r Aral Sea e Caspian D a L. Balkhash i Sea n Sea b TURKEY GEORGIA o a e G Huang a n ARMENIA Korea OCEAN h BURKINA S CHINA e AZERBAIJAN LIBYA CYPRUS UZBEKISTAN a a LEBANON TURKMENISTAN KYRGYZSTAN East r ISRAEL SYRIA NIGER China a Euphrates JORDAN Sea TAJIKISTAN

EGYPT NIGERIA D IRAN Yangtze L. Chad e IRAQ AFGHANISTAN Plateau s Red Sea KUWAIT H of CHAD e Taiwan CAMEROON i Tibet r SAUDI ARABIA m Nile BAHRAIN t NEPAL a BHUTAN PHILIPPINES QATAR OMAN PAKISTAN l South Indus a y a Salween China C.A.R. VIETNAM SUDAN U. A. E. Sea GABON Congo Ganges LAOS ERITREA BANGLADESH MYANMAR Mekong CONGO OMAN INDIA Arabian Sea THAILAND DEM. REP. YEMEN Bay OF CONGO KAMPUCHEA DJIBOUTI of INDONESIA Bengal Singapore ETHIOPIA BRUNEI

UGANDA SOMALIA ANGOLA RWANDA MALAYSIA BURUNDI L. Victoria KENYA MALAYSIA SRI LANKA SINGAPORE TANZANIA

L. Malawi ZAMBIA INDONESIA MALAWI Malaysia

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MADAGASCAR I

Capitalize on the opportunity in Asia! Invest in the premiere issue of PharmTech Asia and receive a charter advertiser rate. Lock in to that rate and continue your program in all four Quarters of 2006. Invest in the brand you trust!

f A SAMPLE OF THE EDITORIAL MIX IN PHARMTECH ASIA…

Manufacturing Equipment & Supplies • API • Excipients • Outsourced Services • Validation/Compliance • Separation/Filtration/Chromatography • Analytical Testing • Formulation • Solid Dosage Manufacturing • Biotechnology/Large-Molecule Processes • Controlled Release • Coating & Coloring • Regulatory Issues • Standards • IT Automation • Process Control/PAT • Drug Delivery Technology

PHARMA TECH ASIA March 2006 GROSS RATES — US DOLLARS AD DIMENSIONS WID TH DEP TH Ad Close: January 23 1X (b/w) 4X (b/w) Full Page 6 3/4” 9 1/2” June Ad Close: April 24 Full Page 5,500 5,000 2/3 Page 4 1/2” 9 1/2” September 2/3 Page 4,675 4,250 1/2 Page Island 4 1/2” 7” Ad Close: July 24 1/2 Page 3,850 3,500 1/2 Page Horizontal 6 3/4” 4 5/8” December Ad Close: October 23 1/3 Page 3,125 2,850 1/2 Page Vertical 3 3/8” 9 1/2”

1/4 Page 2,400 2,200 1/3 Page Square 4 1/2” 4 5/8”

1/3 Page Vertical 2 1/8” 9 1/2” COLORS 1/4 Page 3 3/8” 4 5/8” Standard 625

Four-Color 1,050 COMPONENT WID TH DEP TH

Trim Size 7 3/4” 10 1/2” SPECIAL POSITIONS Bleed 8” 10 3/4” Cover 4 650 Live Matter 7” 9 3/4” Cover 2 & 3 550 Spread Size 14 1/2” 9 1/2” Page 3 500 Bleed (Spread) 15 3/4” 10 3/4”

* Pharmaceutical Research and Manufacturers of America, 2005 ** Publisher’s Own Data STANDARD TERMS AND CONDITIONS FOR ADVERTISING The following terms and conditions (the “Standard Terms”) shall be incorporated by reference into all Insertion Orders submitted to Advanstar Communications Inc. (“Publisher”) by Advertiser or its advertising agency:

A Invoices are rendered at date of publication. B Publisher holds the Advertiser and its advertising agency jointly responsible for paying all duly authorized advertising inserted in or attached to Pharmaceutical Technology. All past due payments may be reinvoiced directly to the Advertiser, who will be held fully responsible for payment. C Terms: Invoices are rendered on the publication date of each issue and are due upon receipt. Agency commission will be disallowed on all past due invoices. In the event Advertiser’s account is placed for collection, Advertiser and agency agree to pay Publisher for all reasonable collection costs and/or attorneys’ fees incurred. Advertiser and agency also agree to pay finance charges on the unpaid account balance at the rate of 1-1/2% per month or the maximum permitted by law. D Publisher will not be bound by any terms, conditions or provisions appearing on insertion orders or copy instructions which conflict with provisions of these Standard Terms, including, without limitation, sequential liability statements from advertising agencies. In the event of any inconsistency between an insertion order and/or copy instructions and these Standard Terms, the Standard Terms shall control. E All advertisements are accepted and published by the Publisher on the representation that the agency and/or Advertiser are properly authorized to publish the entire contents and subject matter thereof. F Advertiser hereby grants Publisher the right and license to use, reproduce, transmit, and distribute all creative materials supplied by or on behalf of Advertiser, including without limitation, all text, graphics, illustrations and photographs (the “Creative”). Advertiser represents and warrants that: (i) it has all the necessary rights in the Creative; (ii) the Creative does not violate any applicable law or regulation; and (iii) the Creative does not violate or infringe upon any third party right in any manner or contain any material or information that is defamatory, libelous, slanderous, that violates any person’s right of publicity, privacy or personality, or may otherwise result in any tort, injury, damage or harm to any person. Advertiser acknowledges that Publisher is relying on the foregoing representations and warranties. Advertiser agrees to indemnify, defend and hold Publisher and its affiliates, and their respective officers, directors and employees, harmless from and against any and all expenses and losses of any kind (including reasonable attorneys’ fees and costs) incurred based upon a breach of any of the foregoing representations and warranties or in connection with any claim arising from or related to any advertisement supplied by Advertiser or its agents and run by Publisher. G Publisher reserves the right to reject any advertising which Publisher feels is not in keeping with the publication’s standards or for any other reason, even if the advertising has been published previously by Publisher. H Publisher shall not be liable for any omitted, misplaced, or mispositioned advertisements. I All orders are accepted by Publisher subject to change in rate upon notice from Publisher. J Orders may be cancelled within ten (10) business days of the effective date of a change of rates without incurring a shortrate adjustment, provided the Advertiser’s contract rate has been earned as of the date of cancellation. K Advertiser will be shortrated if, within a 12-month period from the date of the first insertion, Advertiser does not use the amount of space upon which its billings has been based. Advertiser will be rebated if, within a 12-month period from the date of the first insertion, Advertiser has used sufficient additional space to warrant a lower rate than that at which it has been billed. L A 1/4 page ad is the minimum rate holder. M Advertiser will be shortrated if, within a 12-month period from the date of the first insertion, Advertiser does not use the amount of space upon which its billings has been based. Advertiser will be rebated if, within a 12-month period from the date of the first insertion, Advertiser has used sufficient additional space to warrant a lower rate than that at which it has been billed. N Costs incurred by Publisher for production work on advertisements will be charged to the Advertiser regardless of whether or not the ad runs. Advertiser will be charged for any artwork, separations, halftone, shipping, or typography provided by Publisher. O In the event a change of copy is not received by Publisher by the publication’s ad closing date, the copy run in the previous issue of the publication will be inserted. P Publisher will hold Advertiser’s materials for a maximum of one year from last issue date. It is the responsibility of the Advertiser to arrange for the disposition of artwork, proofs or digital materials prior to that time, otherwise materials will be destroyed. All requests must be submitted in writing. Q Publisher will not be held responsible for consequential costs or other damages due to loss or damage of digital ad materials, art, proofs or transparencies. R Reader response inquiries are provided as a service. Publisher disclaims all liability and responsibility for inaccuracies. S Under no circumstances shall Publisher be liable for any indirect, incidental, special or consequential damages (including, without limitation, loss of profit or impairment of goodwill) of any Advertiser. Under no circumstances shall Publisher’s direct or indirect liability to any advertising agency or Advertiser exceed the invoiced cost of the advertisement. Notwithstanding the foregoing, Publisher shall have no liability for (i) any failure or delay resulting from conditions beyond Publisher’s control; or (ii) errors in content or omissions in any creative or advertising materials provided by Advertiser. T These Standard Terms, together with insertion orders submitted by Advertiser, (i) shall be governed by and construed in accordance with the laws of the State of New York and the United States, without giving effect to principles of conflicts law; (ii) may be amended only by written agreement executed by an authorized representative of each party; and (iii) constitute the complete and entire expression of the agreement between the parties, and shall supersede any and all other agreements regarding the subject matter hereof, whether written or oral, between the parties. Failure by either party to enforce any provision of these Standard Terms shall not be deemed a waiver of future enforcement of that or any other provision. Advertiser may not resell, assign, or transfer any of its rights hereunder.

COMMISSION Accredited advertising agencies receive a 15% commission provided invoices are paid within 30 days. Production charges are not subject to agency commission.

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