353

INDEX VOL. 12-15

Die Stichworte des Sachregisters sind in der jeweiligen Sprache der einzelnen Beitrage aufgefiihrt. Les termes repris dans la Table des matieres sont donnes selon la langue dans laquelle l'ouvrage est ecrit. The references of the Subject Index are given in the language of the respective contribution.

14 AAG (Alpha-acid glycoprotein) 120 14 Adenosine 108 12 Abortion 151 12 Adenosine-phosphate 311 13 Abscisin 12, 46, 66 13 Adenosine-5'-phosphosulfate 148 14 Absorbierbarkeit 317 13 Adenosine triphosphate 358 14 Absorption 309, 350 15 S-Adenosylmethionine 261 13 Absorption of drugs 139 13 Adipaenin (Spasmolytin) 318 14 - 15 12 Adrenal atrophy 96 14 Absorptionsgeschwindigkeit 300, 306 14 - 163, 164 14 Absorptionsquote 324 13 Adrenal gland 362 14 ACAI (Anticorticocatabolic activity in• 12 Adrenalin(e) 319 dex) 145 14 - 209, 210 12 Acalo 197 15 - 161 13 Aceclidine (3-Acetoxyquinuclidine) 307, 13 {i-Adrenergic blockers 119 308, 310, 311, 330, 332 13 Adrenergic-blocking activity 56 13 Acedapsone 193,195,197 14 O(-Adrenergic blocking drugs 36, 37, 43 13 Aceperone (Acetabutone) 121 14 {i-Adrenergic blocking drugs 38 12 Acepromazin (Plegizil) 200 14 Adrenergic drugs 90 15 Acetanilid 156 12 Adrenocorticosteroids 14, 30 15 Acetazolamide 219 12 Adrenocorticotropic hormone (ACTH) 13 Acetoacetyl-coenzyme A 258 16,30,155 12 Acetohexamide 16 14 - 149,153,163,165,167,171 15 1-Acetoxy-8-aminooctahydroindolizin 15 Adrenocorticotropin (ACTH) 216 (Slaframin) 168 14 Adrenosterone 153 13 4-Acetoxy-1-azabicyclo(3, 2, 2)-nonane 12 Adreson 252 311 14 Adreson N® 141 13 3-Acetoxybenzoquinuclidine 312 14 Adsorbentien 363, 365 15 trans-( + )-2-Acetoxy-cyclopropyltrime- 14 Adsorption 363 thylammonium 250 14 Aerosolpraparate 324 12 170(-Acetoxyprogesterone 78 13 Aescin 35, 64 13 3-Acetoxyquinuclidine 307,330 15 Agantuka 15 13 2-Acetylaminofluorene 145 14 Agrocybin 530 13 Acetylations 149 14 Agropyren 478, 517, 525 14 Acetylcholine 35, 43, 77, 86, 89 14 Agropyron repens (L.) 517, 525 13 Acetylcholine, antagonists of 37 13 Ajmalicine 19 14 Acetylcholine esterase 23, 84 12 Ajmaline 296, 313 13 Acetylcoenzyme A 258 13 - 48, 57, 60 14 Acetylen 389 13 Ajmaline camphor-10-sulphonate 62 14 Acetylen-Verbindungen 487,525 13 Akuammidine 50 13 N-Acetylneuraminic acid 345 13 Akuammine 50 14 Acetylphenylacetylen 482 14 Albumin 24, 74, 75, 105 13 2-Acetylquinuclidine-3-acetic acid, 12 Alcacyl 238 derivatives of 300 12 Alderline 322 13 Acetylsalicylic acid 160 14 Aldosterone 124, 125 12 Achromobacter 372 15 Alkaloids 216 14 Acidic polysaccharides 93 14 Alken-(1)-in-(4)-ole-(3)-carbamate 397 12 Aconcen® 151 14 Alkindiole-(1,2) 417 12 Aconitine 313 14 Alkinole 390 12 ACTH (Adrenocorticotropic hormone, 14 Alkin-(2)-ole-(1), tertiare 407 adrenocorticotropin) 16, 30, 155 14 Alkin-(3)-ole-(1), terti are 396,408 14 - 149, 153, 163, 165, 167, 171 14 N-Alkinyl-athanolamine 422 15 - 216 14 Alkinyl-Barbitursauren 422 14 Actinomycin 103 14 1-Alkinyl-4-phenylpiperidinole-(4), Ester 13 4'-(N-Acylsulfanilyl)ar,Hides 192 463 12 Adams-Stokes syndrome 337, 339 14 4-Alkinylpiperidinol-(4)-ester 457 12 Addis co un t 444 13 3-Alkoxycarbonylmethylene-quinucli- 12 Addison's disease 140 dines 303

23 Jucker 15 354 Index \'01. 12-15

14 K-Alkyl-N-alkinyl-1-aminoindane 456 12 Aminoglycoside 386 14 2-Alkyl-3-aryl-4-quinazolone 226 15 1-Amino-2-( 4-imidazol yl)cyclopropane• 13 3-Alkyl(aryl)-quinuclidines 303 carboxylic acid 253 13 Alkylguanidines 110 13 N-Amino-methyldopa (MK-485) 105 14 3-Alkyl-4-propin-(2)-ylpiperidinole-( 4), 15 6-Amino-penicillanic acid 214 Ester 462 14 2-Amino-pentin-(4)-saure 481 14 4-(1)-Alkylpropin-(2)-yl)-piperidinole-( 4), 15 p-Aminophenol 153 Ester 463 15 1- (4-Aminophen yl)-I-(2-amino-4- 14 2-Alkyl-4(3H)-quinazolones 253 thiazol yl)cyclopropanc 253 15 Allethrin 264 14 Aminophyllin 281 12 Allochrysin 229 12 Aminopterin 218, 220 13 Alloferin 37, 38 12 Aminopyrin (Aneuxol, Dimapyrin, 12 Allopurinol (Zyloric) 32, 286, 287 Dipyrin, Pyramidon) 22, 240 15 - 217 14 - 359 13 Allosteric inhibition 49 14 2-Amino-4(3H)-quinazolones 248 14 - 42 13 4-Aminoquinolines 176,177,178,207 14 Alloxan 199 14 - 76 15 5-Allyl-5-bromcyclohexenyl-thiobarbi- 13 8-Aminoquinolines 210 turat 150 14 - 76 12 Allylestrenol (Gestanon®) 150, 152 13 4-Aminoquinoline salts 208 14 DL-5-AUyl-5-(1-methylpentin-(2)-yl)-2- 13 3-Aminoquinuciidine 305 thiobarbitursaure 403 13 4-Aminoquinuclidine 305 12 Alphaprodine 21 12 p-Aminosalicylic acid 19 12 Alpha-receptor-blocking agents 324 14 p-Aminosalizylsaure (PAS) 305 14 Alprenolol 38 15 1-( 2-Amino+ thiazol yl) -2-( 4-amino• 15 - 113 phenyl)cyclopropane 253 12 Alseroxylon 314 13 Amiquinsin 124 14 Aluminiumhydroxyd 320 14 Amisometradine 24 14 Aluminiumoxid 363 12 Amitriptylin(Elavil, Laroxyl, Saroten, 15 Amanita muscaria 73 Tryptizol) 208, 316 12 Amantadine 19 15 Amobarbital 189 13 - 163 14 Amobarbital-Natrium 281 12 Ambonestyl 306 13 Amodiaquine 176, 178 12 Amenorrhoea 59, 66 13 Amoebiasis 33 12 Amethopterin 17, 218, 221 12 Amotriphene (Myordil) 317 13 - 156 12 Amphetamin(e) 24 13 Amethopterin, plasma levels of 159 14 - 18 13 Amidopyrine 161 15 - 161 13 Amidopyrine, demethylation of 162 12 Amphotericin B 19 13 Amino acid conjugations 149 15 - 215 13 9-Aminoacridines 207 12 Ampicillin 378, 379 14 1-Amino-acyl-2,3-dihydro-4(IH)- 14 Amylopectin 88 quinazolones 261 14 Amylose 345, 363 14 2-Aminoalkin-(4)-diole-(1,3) 402 13 [J-Amyrin 35 14 w-Amino-alkin-(l)-ole 439 13 Amyzil 318 14 Aminoalkinole, quart are 427 12 Anabolic steroids 142, 143 14 3-(tert.-Aminoalkinyl)-1-methylpiperidine 15 Anaemia 39, 54 463 13 Anaesthesia 331 13 3-Aminoalkoxyquinuclidine derivatives 14 Analeptica 441 315 13 Analgesic acitivity 160 13 Aminoalkyl-guanidines 116 12 Analgesic agents 21 14 4-Aminoantipyrin 355 14 - 225, 234 12 p-Aminobenzonic acid (PABA) 391 12 Analgesine 240 15 - 281, 293, 307 12 Analgetika 240 15 4-Aminobiphenyl 173 15 - 186 14 4-Amino-butin-(2)-ole-(1) 438, 439, 446 14 Analgetische Wirkung 457,459, 460 14 4-Amino-butin-(2)-01-(1), Ester 436, 13 Anaphylactic shock 353 437, 442 14 - 207 14 4-Amino-butin-(2)-ol-(1), 13 Anaphylactoid oedema 350 N-Pheny1carbamate 437 14 Anaphylactoid reaction 197 14 1-( 4-Aminobutin-(2)-yl)-barbitursauren 13 Anaphylatoxin 354 424 13 Anaphylaxis 347, 353 14 1,3-(4-Aminobutin-(2)-yl)-barbitur- 15 Anatomy 36 sauren 424 12 Androgen 146 14 N-(4-Aminobutin-(2)-yl)-dicarbonsaure- 12 Androgenic activity 145 imide 429, 434 12 Androgenic steroids 142, 143 13 €-Aminocaproic acid 357 12 Androgens 81 15 1-Amino-trans-2- [4-( 3, 5-dibromo-4- 14 Androstanolone 163, 164, 183 hydroxyphenoxy)-3,5-diiodophenyIJ 14 4-Androsten-3,17-dione 153 cyclopropanecarboxylic acid 253 14 Androstenediol dipropionate 163 14 Q(-Aminoessigsaure 357 13 Androstenedione 272 Index Yol. 12-15 355

14 Andros teron 314 14 Antidepressiva 453 13 Androsterone 271 12 Antidepressive agents 315 14 Anemia 177,178 12 Antidiabetes agents 16 14 Anesthesia 105, 107 14 Antidotal action 22 15 - 85 14 Antidote 20, 365 12 Anesthetics 21 14 An tiepileptic action 228, 229 14 - 105 12 Antiepileptics 314 12 Aneural 190 12 Antifertility effects 110 12 Aneuxol 240 13 Antigen 353 14 Angina pectoris 452 12 Antihaemorrhagic activity 147 14 Angioedema 214 12 Antihistamine 30, 309 13 Angbneurotic oedema 351 14 - 92,93,95 12 Angiotensine 333, 334 14 Antihistaminic activity 258 12 Anileridine 21 15 Antihistaminikum 194 13 Anilin(e) 161 14 Antihistaminische Wirkung 404 15 - 153,170,172 14 Antihypertensive activity 245 13 Anisatin 64 12 Antihypertensive agents 28 15 Anna 16 13 - 104 15 Anorectic activity 244 14 - 246, 247 14 Anorexia nervosa 182 14 Antihypertonikum 467 12 Anovlar® 150 14 Anti-infectious agents 45, 46, 50 13 Ansiv (HT-1479) 121 13 Anti-inflammatory action 62 15 Antagonism 317,321 14 - 254 14 Antagonism, irreversible 44 15 Anti-inflammatory activity 257 14 Antagonists 35, 36, 39 13 Anti-inflammatory agents 36 12 Antazoline (Antistine) 310 14 - 70, 73, 174, 234 15 An thelmin tic agent 143 15 - 221 14 Anthelmintische Wirkung 396 15 An tikoagulan tien 150 13 Anthrone glycosides 28 14 Antikonvulsive Wirkung 401, 404 14 Antiadrenergic activities 261 14 Antikonvulsivum 395, 399 13 Anti-amoebal drug 39 12 Antileukemic agent 17 14 Antiamoebic action 256 13 Antimalarial activity 174, 178 12 Antiandrogen 146 14 - 225 12 Antianginal agents 27 13 Antimalarial drugs 171, 207 15 Antianxiety agent 265 14 - 76, 221 12 Antiarrhythmic action 299 13 Antimalarial drugs, classification of 172 14 - 111 13 Antimalarial drugs, degradation of 178 12 Antiarrhythmic activity 297, 308, 336 13 Antimalarial drugs, excretion of 178 12 Antiarrhythmic agents 293, 303, 344 12 An timalarials 300 12 Antiarrhythmic drugs 294, 295, 336 12 Antimalariamittel 230 12 Antiarrhythmic effect 294, 296 12 Antirnalariarni ttel, N e benerschein un gell 12 Antibacterial activity 441 231 14 - 259 14 Antimetabolites 38 15 - 337 15 Antimicrobial activity 334 12 Antibacterial agents, testing 444 12 Antimicrobic drugs 374 12 Antibacterial substances 396 15 - 283 15 Antibiotic action 313 14 Antimikrobielle Wirkung 486 15 Antibiotic combinations 317 14 Antimitotic activity 260 15 Antibiotic concentration 311, 288 15 Antimycobacterial activity 253 12 Antibiotics 380, 383 14 Antimykotikum 485 14 -101 13 Antineoplastic drug 32 15 - 214, 285 12 Antioestrogens 113, 114 12 Antibiotika 215 14 Antiparkinson-Mittel 436 14 Antiblastin 528 12 Antiphlogistika 240 13 Anti-cancer agents 31 14 Antiphlogistische Wirksamkeit 459 14 Anticholinerge Wirkung 437 14 Antipyretic agents 234 13 Anticholinergic activity 319 14 Antipyretische Eigenschaften 404 13 Anticholinergic agent 318 12 Antipyretische Wirkung 233, 235 14 - 36, 37, 43 12 Antipyrin(e) 240 14 Anticholinesterase activity 258 13 - 161 14 Anticoagulants 74 14 - 26, 27 15 Anticoccidial activity 266 13 Antipyrine, biologic half-life of 162 15 Anticonceptiva 186 12 Antiseptic agents 27 14 Anticonvulsant activity 238 14 Antiseptikum 485 12 Anticonvulsants 22 14 Antiserotonins 37 14 - 220, 227, 234, 236, 237 14 Antispasmodic activity 257 14 Anticorticocatabolic activity index 12 Antistine 310 (ACAI) 145 12 Antistreptokokkentherapie 215 14 Anticortisone agents 184 12 Antistreptolysintiter 178 13 Antidepolarizing activity 328 12 Antithyroid drugs 158 15 Antidepressant 243 14 Antitubercular agents 249 356 Index Yol. 12-15

13 Antitussive activity 248 14 Athynyliistradiol (EE) 331, 366 14 - 261 15 Atoxyl (Phenylarsonsaure) 160 12 Antitussive agents 30 14 ATPase 97 13 Antitussive properties 38 12 ATPase activity 305, 317 14 Antitussivum 458 14 A trial cell 99 14 Antiviral activity 259 13 Atromid S® 254 12 Anturan 241, 286 12 Atropine 339 12 Anxiolytischer Effect 193 14 - 43, 77, 78, 112 13 Aprolidine 319 12 Atropine sulphate 81 13 Aprophen 318 12 Aubromid 228 13 APS (Adenosine-5'-phosphosulfate) 148 12 Auritussin 228 14 Aquamycin 528 12 Aurobrom 228 12 Aralen 232 12 Auro-Calcium 229 13 Aralkyl-guanidines 111 12 Aurocidin 229 13 Arjunolic acid 36 12 Aurodetoxin 230 12 Arlef 262 12 Aurolin 229 13 Armine 319 12 Auropex 229 12 Arrhythmias 337 12 Auropin 229, 339 15 Arrhenius equation 300 12 Aurosan 229 15 Arsanilsaure 164 12 Aurothion 229 12 Arsphenamine 17,390 12 Aurubin 229 13 Arteriosclerosis obliterans 227 12 Aurumin 230 12 Arthritis 15, 168 15 Aushadha 16 14 -168,175,176 12 Aventyl 208 15 - 213 13 Avidin 343 12 Arthronosis 266 12 Avloc1or 232 12 Arthrosis 266 13 AY-9944 (trans-l,4-Bis(2-chlorobenzyl- 13 Aryloxy acids 257 aminomethyl)-cyc1ohexane) 265 13 ex-Aryloxyisobutyric acids 253 15 Ayurveda 15, 27 14 3-( 4-Aryl-l-piperazinylalkyl) -2, 4(1 H, 13 1-Azabicyclo-(3, 2, 2)-nonane 306 3H)-quinazolinediones 247 13 20-Azacholesterol 271 14 1-Aryl-propin-(1)-ylamine 464 13 Azacholesterols 271 14 Arzneiformen 272 12 8-Azaguanine 106 14 Arzneimittelwirkung 284, 288 13 Azaindoles 123 14 Arzneipflanzen 522 13 Azamethonium bromide 324 14 Arzneistoffabsorption 290 12 Azaserine 112 14 Arzneistoffdosis 273, 290 15 - 215 14 Arzneistoffe 296 13 Azasteroids 269 15 - 148 13 Azasterols 269, 270 14 Arzneistoffkristalle 309 12 Azathioprin(Imuran, Imurel) 218, 220 14 Arzneizubereitung 273 15 - 162 12 Ascorbic acid 13 14 p-Azetamidophenol 328 14 Askorbinsaure 281, 352 14 Azetaminophenon 366 14 Aspartate 306 12 Azetylsalizylsaure (Aspirin) 238 12 Aspirin® 22, 238, 334 14 - (ASS) 296,297,307, 14 - 279 318, 334, 360, 362 14 ASS (Azetylsalizylsaure) 296, 297, 307, 14 Azetylsalizylsaure-Tabletten 296 318, 334, 360, 362 13 Azo-reductase 145 12 Asthma 30 13 - 39 12 Bacteria 442 14 - 149,182 12 Bacterial count 44, 446 15 - 39 15 Bacterial growth 276 12 Atarax 191, 311 15 Bacterium coli 49 12 Ataraxic drugs 101 14 Bakteriostatische Wirkung 478, 479,484 14 Athanol 355 14 Bakterizide Wirkung 477,482 13 Atherogenesis 219 14 BAL (Britisch Anti-Lewisite, dimecap- 13 Atheromatosis 220 roll 21, 22 13 Atherosclerosis 219, 231, 232 12 Balneotherapie 210, 279 15 Atherspaltung 154 12 Bang's disease 420 14 6-Athiny1codein 456 15 Banisteriopsis caapi 73 14 1-Athiny1cyclohexanol 390, 408 14 Banthine 79,112 14 1-Athiny1cyclohexanol, Carbamate 410 12 Barbituric acid derivatives 82 14 l-Athiny1cyc1ohexylallophanat 394 12 Basal body temperature (BBT) 57, 60 14 l-Athiny1cyclohexy1carbamat 394 13 Basal metabolic rate 152 14 l-Athiny1cyclopentanol 393 13 BBCO (Benzyl benzoate castor oil) 14 l-Athinyl-decahydro-naphthol-(l) 393 174, 198 14 Athinyliistradiol 331, 366 12 BBT (Basal body temperature) 57, 60 14 17ex-Athinyliistradiol 388,473 13 Benactizine (Amyzil) 318 14 Athusin 518, 526 12 Benactyzine 311 14 Athylendiamintetraessigsaure (EDTA) 14 - 118 340, 355 12 Benadrine 310 Index Vol. 12-15 357

14 Benadryl 79 13 N, N'- Bisnortoxiferine I 38 12 Benemid (Probenecid) 286 12 Bisulfonamides 406 14 Benzacyl® 305 12 Blastocyst, implantation of 111 14 Benzhydrilaminoathylather, 12 Blastomycosis 420 alkin ylierte 449 13 Blood histamine 361 13 3-Benziloyloxyquinuclidine 321 13 Blood-lipid values 223 14 Benzilsaure-ester 465 13 Blood pressure 103 13 Benzmalecene 240 15 Blood transfusion 35 14 Benzokain 354 13 Blood volume 152 14 Benzoy1choline 86 15 Bodhisatvapadana Kalpalata 35 13 3-Benzoyloxy-1-azabicyclo(3, 2, 2)• 13 Body surface area 152, 154 nonane 317 14 Blutdruckregulierende Wirkung 437 13 3-Benzoyloxymethylquinuclidine 316, 12 Blutsenkungsgeschwindigkeit 178 317 13 Bombus terTestris 42 13 3-Benzoyloxyquinuclidine 313, 331 13 Bordetella pertussis 353 14 Benzoylphenylacetylen 478, 482 13 Boshnialactone 65 12 Benzydaminhydrochlorid (ImotryJ, 13 Boxidine 239 Tantum) 263 12 Bradykinin 333 15 1-Benzy1cyclopropylamine 244 13 - 127, 351, 356 13 Benzylguanidines 111 14 - 199, 206, 213, 215 12 Benzylpenicillin (Penicillin G) 375 15 - 216 14 - 296 14 Bradykinin, antagonists of 208 15 - 214 14 Bradykininogen 200 13 0(-Bergamotene 17 12 Bretylium 325 13 ,8- Bergamotene 17 13 - 111 14 Bernsteinsaure 357 14 British anti-lewisite (BAL) 22 15 Beta-blockade, metabolic effects of 117 14 I-Brom-alkin-(I)-diole-(3,4) 399,419 15 Beta-blocking activity 106 14 I-Brom-alkin-Il)-ole-(4) 414 15 Beta-blocking drugs 107 14 1-(2-Bromathinyl)-cydohexanol 398 14 Betamethasone acetate 183 14 Bromide intoxication 25 12 Beta-receptor-blocking agents 321 14 I-Brom-3-methylpentin-(1)-ol-(3) 398 12 Bethanidine rEsbatal) 325 14 Bronchodilators 252 13 - 111 15 Bufotenine 76 13 Bialamicol 173, 176 14 Busulfan 473 12 Biallylamicol 20 12 Busulphan (MyJeran) 53 14 Biformin 521, 528 12 Butadrine 349 15 Bilirubin 180 12 Butazolidin 241, 283 14 Bioactivation 31 14 Butin-(2)-diol-(1,4), Arylsulfonsaure- 14 Biodegradation 27 ester 475 14 Bioinactivation 25 14 Butin-(3)-ole-(1), sekundare 406 15 Bioinaktivierung 155 14 Butin-(3)-saure 480 13 Bioisosterism 62 14 Butin-(2)-ylendiamine 431 15 Biological activity 334 14 Butin-(2)-ylendiamine-(1,4) 430 14 Biological membranes 24 15 Butidrine 110 14 Biopharmazie 271 14 Butoxamine 38 13 Biopolymers 203 14 3-(P-Butoxyphenyl)-2-alkylthio- 12 Biotin 13 4(3H)-quinazolones 251 15 - 212 14 1-Butyl-butin-(3)-ol-(1) 391 15 Biotransformation 148, 155 14 N-tert.-Butyl-N-[l,l-dimethyl- 13 2-p-Biphenylylbutric acid 249 propin-(2)-yIJ-methylamin 467 13 2-(p-Biphenyl)-4-hexenoic acid 250 13 5- (4- Bi phen ylyl) -3-meth ylvaleric acid 25l 14 Cadaverine 88 13 4',4'" -Bis-(N -acetylsulfonilyl)• 13 Caerulein 127 alkylenebisanilides 194 12 Caesarian section 61 13 1,3-Bis-(,8-aminoethoxy)-benzenes 14 Caffeine 47 derivates 329 12 Calaurol 229 15 1,1-Bis-( 4-aminophenyJ)cyclopropane 12 Calciferol (Vitamin D 2) 13 254 12 Calcitonin 159 13 1 ,6-Bis-(3', 3'-benzylquinuclidile- 15 - 216 1', 1')-hexane, dichloride 331 12 Calcium 336, 346 13 2, 2-Bis-(p-chlorophenyl)-I, 1- 14 - 110, 113 dichloroethane 147 14 Calcium metabolism 151 13 2, 2-Bis-(P-chlorophenyl)-I, 1, 1- 13 Callicarpa candicans 64 trichloroethane 146 13 Callicarpone 64 13 2, 2-Bis-(P-chlorophenyJ)-I, 1- 13 Calorigenic action 244 dichloroethylene 147 13 Camolar® 184 13 Bis-(4,6-diamino-1,2-dihydro- 15 Campolon 43 2,2-dimethyl-s-triazines) 180 13 Camptothecin 33 12 Bishydroxyconmarin 27, 33 13 Cancer 31 14 Bishydroxykoumarin 291 14 - 181 14 1,6-Bis-morpholino-hexadiin-(2, 4) 469 15 Cannabis 71 358 Index \'01. 12-15

13 Cannabis resin (Marihuana) 14 12 Chiari·Frommel syndrome 61 15 Cannabis sativa 74, 78 14 Chinidinbase 300 13 Capenicin 15 14 Chinidinsulfat 300 14 Capillen 525 12 Chloracizine 312 14 Capillin 517, 525 12 Chloralhydrate 21, 23 12 Capla (Mebutamate) 346 14 - 32 14 CAPP (Chloramphenikolpalmitat) 12 Chlorambucil (Leukeran) 218, 220 307, 315 12 Chloramphenicol 18, 376, 385 C arassius auratus 236 14 - 28, 45, 316, 325, 328, 366, 369 12 Carbenicillin 380, 385 15 - 181, 215, 281, 28~ 285, 291, 300, 13 Carbenoxolone sodium 34, 35 311, 326, 327 14 Carbimazole 32 H Chloramphenikolpalmitat (CAPP) 307, 13 Carbohydrate metabolism 361 315 13 Carbohydrates 358 14 1 ·Chlor·3·athyl-penten-(lHn-( 4 )-01-(3) 14 - 151 399 12 Carbromal 22 15 Chlordiazepoxide (Librium) 219 12 Carbutamide (Nadisan®) 157 12 Chlordiazepoxyd (Librium) 23, 25, 83, 13 Carcinoma 31 191, 192 12 Cardiac arrhythmias 293 13 Chlorguanide hydrochloride 179 12 Cardiac glycosides 325 13 Chlorguanide pamoate 180 14 - 97 14 Chlorisondamine 79, 112 13 Cardiac outputs 153 12 Chlormadinone 78, 79, 97, 151 14 Cardiac puncture 205 12 Chlormethazone (Chlormezazone, 12 Cardiac rhythm 329 Trancopal) 198 14 Cardioactive drugs 97, 98 12 Chlormezazone 198 12 Cardiovascular agents 27 13 Chlorocyclizine 238 ]2 Carisoprodol (Flexartal, Sanoma, Soma, 12 Chloroguanide 20 Somalgit) 197 14 4-Chloro· 19-nortestosterone 142 13 - 141, 162 15 N· [2-(o-Chlorophenoxy)ethyl]cyclo- 14 Carlinaoxid 478, 519, 525 propylamine 246 14 Carotatoxin 518, 526 13 p-Chlorophenoxyisobutyric acid 228 13 #·Carotene 67 12 Chloroquine 20, 231, 303 13 Carotenoids 67 13 - 176 13 Carquejol 50 14 - 18, 291 14 Carrageenin 214 12 Chloroquinphosphat (Aralen, Avloclor, 14 Carragenan 94 Resochin) 232 13 o·Carvocrotonic acid, derivatives of 61 14 7 -Chloro-6-sulfamyl-4(3H)-quinazolones 14 Casein 81, 94, 111 243 13 Catalepsia 321 14 Chlorotestosterone 144, 180 13 Catapresan 118 14 Chlorotestosterone acetate 165, 181 ] 3 Catecholamines 103 14 4-Chlorotestosterone acetate 142 14 - 92 15 7 -Chlorotetracycline 300 ] 3 Catechol-O·methyl transferase inhibitors 12 Chlorothiazide 26 108 13 - 125 13 Catharanthine 19, 33 14 - 243 13 Catharanthus roseus G 19, 21, 31 15 - 219 ] 2 Catron 316 13 Chlorproguanil hydrochloride 179 14 CBG (Corticosteroid·binding globulins) 13 Chlorproguanil pamoate 180 120 12 Chlorpromazin(e) (Largactil) 23, 25, 30, 13 Celastrol 34 83, 101, 199, 311 15 Cell concentration 276, 286 14 - 79, 92, 110, 113, 114, 115, 116, 117, 15 Cell membranes 129 118, 119, 394 14 Cellocidin 520 15 - 221 14 Cellulose membranes 65 12 Chlorpropamid(e) 16 15 Cephalexin 214 15 - 155 15 Cephaloglycin 214 12 Chlorprothixen (Taractan, Truxal) 201 12 Cephaloridine (Ceporin) 381 12 6-Chlorpurine 112 13 Cephalosporin P, 29, 30, 33 12 Chlorquinsulfat (Nivaquine) 232 12 Cephalothin (Keflin) 381 15 Chlortetracycline 215 15 - 214 14 Chlortetrazyklin 369 12 Ceporin (Cephaloridine) 381 14 Chloruresis 244 15 Cerebral tumour 53 12 Chlorzoxazon(e) (Neoflex, Paraflex) 22, 14 Cerebrosulfate 89,91, 96 198 14 Cetrimid 354 15 - 160 14 Cetyl pyridinium chloride (CPC) 86 14 Cholchicine 108 13 Chamazulene 38 13 Choleretic agents 38 14 Chamomillaester 526 13 LJ4-Cholestanone 269 14 Charcoal 20 13 Cholesterol 266 14 Chelating agents 22 15 - 212, 222 12 Chemotherapeutika 215 13 Cholesterol biosynthesis inhibitors 250, 12 Chemotherapy 390 258, 268 Index Vol. 12-15 359

13 Cholesterol esters 220 15 Coronary thrombosis 48 13 Cholesterol synthesis 268 12 Coronary vasodilator drugs 316 12 Cholestyramine 29 12 Corontin 317 13 - 278 12 Cortancyl 252 14 - 20 12 Cortef 252 13 Cholinergic activity 310, 311, 312 14 Corticoid metabolism 155 14 Cholinergic drugs 43, 77, 110 12 Corticos teroids 31 14 Cholinergic receptor 83 14 Corticosterone 126, 152 14 Cholinesterase 83, 115 12 Cortifor 252 14 Cholinolytica 440 14 Cortisol 144, 162, 164, 170 14 Cholinolytische Wirkung 431,434,441 15 - 212, 213 13 Cholinomimetic activity 332 14 Cortisol acetate 166,174,177,181 15 d-Chondocurarine 216 12 Cortisone 139, 140, 141, 252 15 Chondodendron tomentosum 216 1+ - 143, 144, 164, 165, 169, 170, 175, 179, 14 Chondroitin Sulfate (CSA) 86, 118 180, 181, 183 13 Choriocarcinomas 31 15 - 212, 213 12 Chrysanol 229 14 Cortisone acetate 142, 143, 168, 170, 12 Chrysotherapie 221, 223 172, 174, 181, 183 14 Chymotrypsin 289, 368 12 Cortone 252 13 CI-501 (Cycloguanil pamoate) 184, 197 12 Cortril 252 13 CI-556 (4,4W -Sulfonylbis-acetanilide) 195 13 Corynantheal 20 13 CI-608 (PSBA) 198 12 Corynebacterium diphtheriae 18 13 CI-679 (2,4-Diamino-6-[(3,4-dichloro- 13 Cosubstrates 150 benzyl)nitrosoamino J-quinazoline) 205 14 Cotton effect 68, 72 14 Cicutoxin 518, 526 15 Coulter counter 343 13 Cinchona alkaloids 18, 50 14 Coumermyzin A, 371 13 Cinchonamine 20 12 CPIB (Atromid S®, Clofibrate) 29 13 Cinchonine 51 13 - 254 15 Cinerins 264 14 Cremophor EL® 353 13 Cinnamylguanidine 112 14 Crepeninsiiure 520, 527 14 Citrovorum factor 40 12 Crisalbin 229 13 CI-65,205 (Boxidine) 239 13 Crotocin 17, 40 15 Clindamycin 295,298 13 Crustecdysone 27 12 Clofibrate (CPIB) 29 12 Crystalluria 406 13 - 225, 254, 260 13 Cucurbitacin A 33 12 Clomiphene (MRL-41) 15,49, 56, 66, 15 Culture media 343 67, 110, 118, 155 13 Cuminaldehyde cyanohydrin, gluco- 14 CMC (Karboxymethylzellulose) 303, 343 side of 44 14 CNS-depressant drug 228, 239 12 Cupralime (Ebesal) 230 14 CNS-stimulants 47 12 Curare 31 12 Cocaine 21 14 Cushing's syndrome 145 13 Cochliobolin 40 14 Cyanide poisoning 22 13 Cochliobolin A 40 13 2-(p-Cyanoethyl)-3-ketoquinuclidine 305 13 Cochliobolin B 40 13 Cyclazenine (Guanacline, Leron) 116 13 Cochliobolus miyabeanus 40 15 Cyclazocine 249 12 Codein(e) 30 13 Cycloartenol 33 15 - 157 15 - 260 13 Coenzymes 150 15 Cyclobuxine 260 12 Colcemid 105 15 Cycloeucalenol 260 12 Colchicine 31, 104 13 Cycloguanil hydrochloride 179 13 - 32 13 Cycloguanil pamoate (Camolar®, 15 Colony counter 344 CI-501) 184, 197 14 Combination of drugs 16 13 Cycloguanil salts 181, 183 12 Compound E 250 13 N-Cyclohexyllinoleamide 277 13 Conalbumin 343 15 (±)-trans-2-Cyclohexyloxycyclopropyl- 14 Concentra tion of drug 65 amine 237 13 Conjugation reactions 147 15 Cyclolaudenol 260 12 Conovid® 150 12 Cyclophosphamid(e) (Cytoxan, 12 Contraception, oral 76 Endoxan) 218, 220 12 Contraceptives, effectiveness of 91 13 - 146 12 Contraceptives, oral 15, 85 14 - 181 12 Contraceptives, side effects 92 15 - 166 12 Contraceptive tablets 117 12 Cyclopropane 21 12 Contraceptive therapy 88 14 - 106 13 Conversion factors 155 15 - 228 13 Convulsant activity 317 15 N-Cyclopropyl-2-chloro-6-phenyl- 13 Cordifoline 21 phenoxyethylamine 248 13 Coriamyrtin 15 15 17-Cyclopropylestradiol methyl ether 14 Coronardilatoren 440 256 14 Coronargefiisserweiternde Wi.rkung 402 15 N -Cyclopropylmethyl-nordihydro• 13 Coronary arteriosclerosis 220 morphinone 250 360 Index Vol. 12-15

15 N-Cyclopropylmethyl-normorphine 250 12 Delta-Cortril 252 15 17cx-Cyclopropyl-19-nortestosterone 256 12 Deltafluorlme 253 15 Cyclorphan 249 12 Deltasone 252 15 Cycloserine 215 13 N-Demethylation 145 14 n-Cycloserine 40 13 O-Demethylation 145 15 Cyprolidol 265 15 6-Demethyl-chlorotetracycline 215 15 Cyprome ether 228 15 6-Demethyl-6-deoxy-tetracycline 215 15 Cyproquinidate 266 15 23-Demethylgorgosterol 266 12 Cyproteron 146 13 Dendrolasin 42 12 Cyrpon 190 14 Deoxycorticosterone 126 14 Cysteamine 21 13 ll-Deoxycorticosterone (21-Hydro- 14 Cysteine 78 xypregn-4-en-3,20-dione) 27 12 Cytochrome C 335 13 2-Deoxyglucose 360 15 Cytogenetic effects 89 14 - 199, 208 13 Cytosine arabinoside 164 15 Deoxyuridine 295 13 Cytosine arabinoside, metabolism of 164 15 Depersonalization 95 14 Cytostatische Aktivitiit 474 13 Depot antimalarial preparations 179 14 Cytostatische Wirkung 473 12 Depot-Benzathin-Penizillin 216 12 Cytotoxic drugs 112 14 Depotwirkung 275, 307 13 Cytotoxicity 33 14 Depressive Wirkung 401 12 Cytoxan 220 15 Derealization 95 13 - 156, 157 15 Dermatitis 39 13 Cytoxan toxicity 155 14 Dermatomyositis 173 15 Dermatophytosis 57 12 Dacortin 252 12 Deronil 253 13 DADDS (Acedapsone, Hansolar®, 14 Desaggregationsgeschwindigkeit 327 4', 4 m -Sulfonylbisacetanilide) 193, 195, 14 Desaggregierung 326 201 15 Desalkylierungen 154 13 Dapolar® 197 12 Deserpidine 83 13 Dapsone 190 13 - 56 12 DBI (Phenformin) 157 14 Desferrioxamine 20, 21 15 DCI (Dichloroisoproterenol) 108 12 Desipramin (Norpramin, Pertofran) 207 13 DDD (2,2-Bis-(p-chlorophenyl)- 12 Desmethylimipramin(e) 316 1,I-dichloroethane) 147 14 - 27 13 DDE (2,2-Bis-(p-chlorophenyl)• 15 - 157 -1,I-dichloroethylene) 147 13 Desmosterol 234 13 DDS (Dapsone, Diaphenylsulfone) 190, 12 Desoxycorticosterone (DOC) 332 201 14 Desoxycholsiiure 355 13 DDT (2,2-Bis-(P-chlorophenyl)- 13 Desulfuration 144 -1, 1 , I-trichloroethane) 146 13 Detoxication enzymes 150 13 Dealkylations 145 14 Detoxification 23 14 N-Dealkylation 25 14 Dexamethasonazetat 314 15 Debye interactions 134 12 Dexamethason(e) (Decadron, Delta• 13 Debrisoquine (Declinax) 112 fluorlme, Deronil, Dexa-Scheroson, 12 Decadron 253 Gammacorten, Millicorten, Oradexon) 253 12 Decadurabolin® 143 14 - 126, 150, 165, 170, 178 12 Decamethonium 31 12 Dexa-Scheroson 253 13 Declinax (Debrisoquine) 112 13 Dextran 348, 350, 351, 359 12 Decontractyl 196 14 - 87, 197, 198,201, 211, 215 12 Decortin H 252 14 Dextran shock 200 15 4-Dedimethylaminotetracycline 300 13 Dextrin 359 12 Deflexol 198 14 - 198 12 Degree of severity 447 12 Dextromethorphan 30 13 Dehalogenation 146 13 Dextrothyroxine 225 14 Dehydrazetsiiure 360 13 DFDDS (4',4m -Sulfonylbisformani- 13 24-Dehydrocholesterol (Desmo- lide) 193, 194 sterol) 234 15 Dhatu 17 13 7-Dehydrocholesterol-Ll7-reductase 270 15 Dhara Chikitsa 46 14 Dehydrocrepeninsiiure 527 12 Diabetes 156 14 Dehydroemetin 296 12 Di-Adreson F 252 13 2-Dehydroemetine 39, 51 13 N, N'-Diallylbisnortoxiferine 13 Dehydroepiandrosterone 272 (Alloferin) 37 14 - 153 ' 14 Dialysis 65 14 trans-Dehydromatricariaester 525 14 1-w-Diaminoalkine, bisquartiire 470 14 Dehydropregnenolon 314 13 2,4-Diamino-6-(benzylamino) qui- 13 Ll2-Dehydroquinuclidine 297 nazolines 204 14 Dehydrosteron 314 14 1,4-Diaminobutine-(2) 429 12 Delcortin 252 13 2,4-Diamino-6-(3, 4-dichloroben• 12 Delta-Cortef 252 zylamino) quinazoline 205 12 Deltacortene 252 13 2, 4-Diamino-6-[(3, 4-dichlorobenzyl)• 12 Delta-Cortisone 252 nitrosoamino] quinazoline 205 Index Yo!. 12-15 361

13 4,6-Diamino-l,2-dihydro-l-phenyl- 13 Dihydrocholesterol 269 2-alkyl-s-triazine salts 182 12 Dihydrofolic acid 394 14 2,6-Diaminohexin-(4)-saure 481 12 Dihydrofolic acid reductase 382 12 2,6-Diaminopurine 112 14 Dihydro-ouabain 100 14 Diamox 17 14 3,4-Dihydro-4-quinazolones 260 14 Dianacorten® 141,173,175,176,182 13 Dihydrotachysterol 349 13 Diaphenylsulfone 190 13 Dihydroverbenalin 20 14 4-Diathylamino-butin-(2)-ol-(1), 13 3,4-Dihydroxy-3-methyl-pentanoic Ester 485 acid 261 12 Diathylpropandiol (Prenderol) 197 14 1,2-Dihydroxy-2-methyl-1-phenylbutin- 14 Diatretin I 530 (3) 399 14 Diatretin II 530 14 1,12-Dihydroxyoktadekan (DOD) 303 14 Diatretin III 530 15 Dihydroxyphenathylamin 161 13 1,4-Diazabicyc1o-(3,2,2)-nonane 306 15 Dihydroxy-phenylalanine (DOPA) 72 13 Diazacholesterols 270 15 1-(3,4-Dihydroxyphenyl)-2- 12 Diazepam (Valium) 25, 191, 192 cyc1opropylaminobutanol 246 15 - 157 14 Di-isopropylfluorophosphate 112 13 Diazoxide (Hyperstat) 125 12 Dilantin 314 12 Dibenamine 81, 82, 295, 324, 338 12 Diloxanide 20 14 - 44,92, 104 12 Dimapyrin 240 12 Dibenzepin (Noveril) 208 13 Dimecoline 325, 331 14 Dibenzoylacetylen 483 14 Dimercaprol (BAL) 21 14 Dibenzyline 44,92, 104, 208, 209 12 Dimethisterone 77 14 Dibucaine 110 15 2,5-Dimethoxy-4-methylamphetamine 12 Dichloroisoproterenol (DCI) 321 (DOM, STP) 72, 77 13 - 119 15 trans-2-(2,6-Dimethoxyphenyl)• 15 - 108 cyc1opropylamine 235 15 tyans-2-(2,6-Dichlorophenyl) cyc1opro• 13 Dimethylaminoethanol1,6-dime- pylamine 235 thylpipecolinate 331 13 6,8-Dichloro-2-phenyl-a-2-piperidyl- 14 Dimethylaminoethyl acetate 112 4-quinolinemethanol 175 14 Dimethylandrostanolone 166 13 4'-[N-(3, 5Dichlorosalicylidene)- 14 2, 5-Dimethyl-hexin-(3)-diol-(2, 5), sulfanilylJ acetanilide 203 Propionsaurediester 400 14 Dichroa /ebyi/uga 220 13 7,11-Dimethyl-3-hydroxy-3-phenyl- 14 Dichroine 220 6,10-dodecadienoic acid 248 14 Dichroism 68, 71 15 6,7-Dimethyl-oc-[(isopropylamino)• 13 Dicoline 325, 331 methyIJ-2-benzofuranmethanol 14 Dicoumarol 26 (Ro 3-3528) 114 15 - 150 13 3,5-Dimethylisoxazole 229 14 Dicumerol 75, 76 13 2,3-Dimethyl-5-phenyl-2-trans- 12 Dienoestrol 73, 74 4-trans-pentadienoic acid 248 13 Diet 221, 222 13 1,6-Dimethylpipecolinic acid, esters of 12 Diethazine 312 324 14 2-Diethylamino-6,7-dimethoxy- 14 1,1-Dimethylpropin-(2)-ol-(I)- 4-quinazolone 249 carbamat 392 12 Diethylaminoethanol 304 13 3,5-Dimethylpyrazole 229 13 3-{{1-Diethylaminoethoxy)-1,3,5 12 Dimethylsulfoxyd (DMSO) 257 (10)-estratriene 232 15 Dimethyltryptamine (DMT) 72, 75 13 2-Diethylaminoethylaminomethyl- 13 Diochine 324, 325 quinuc1idine 323 15 Diosgenin 212 13 {1-Diethylaminoethyldiphenyl-, 12 Dioxolane (Glyketal, Promoxolane) 197 propyl acetate 141, 266 12 Diphedan 314 13 2-Diethylaminoethyl nicotinate 227 12 Diphenhydramine (Benadrine) 33, 310 15 {1-Diethylaminoethyl• 12 Diphenox (Phenopyrazon) 241 I-phenylcyclopropanecarboxylate 254 14 Diphenydramine 25, 110 14 3-{1-Diethylaminoethyl-4-quinazolone 12 Diphenylbutazon (Butazolidin, Elmedal, 257 Phenylbutazon) 241,286 14 Diethylstilbesterol 124 14 1,4-Diphenylbutin-(2)-diol-(1,4) 484 12 Diethylstilboestrol 75 12 Diphenylhidantoin (Dilantin, Diphedan) 14 Diffusionsgeschwindigkeit 306 22, 314, 347 12 Digitalis 27, 325, 327, 336, 339, 342 14 Diphenylhydantoin 26, 27 14 - 97 14 1,1-Diphenyl-4-piperazinyl-butin- 12 Digitalis bradycardia 326 (2)-ole-(1) 439 13 Digitoxin 160 12 Diphtheria 406 14 - 40, 98, 101 13 Diplacine 309, 329 15 - 149 12 Dipyridamole 27 14 Digoxin 101 12 Dipyrin 240 13 H3_Digoxin 161 14 1,4-Dipyrrolidino-butin-(2) 13 Dihydroactinidiolide 65 (Tremorin) 427 14 3,4-Dihydrochinazolinon-(4), 12 Disipal 198 Derivate 466 13 Disinfectants 39 362 Index \'01. 12-15

12 Disopyramide (SC 7031) 329, 350 13 Ebelin lactone 14 14 Dispergierung 326 12 Ebesal 230 14 Dispersionskrafte 338 13 Ecdysone 27 14 Dispersitatsgrad 321, 329 13 Echinodol 34 12 Dispril 238 12 E. coli 380, 386 ] 3 Disulfiram (Antabus®, Tetraathylthiu- 14 Edestin 94 ram) 108 1+ Edetic acid (EDTA) 20 15 - 196 14 Edrophonium 43, 85 15 Ditran 85 14 EDTA (Athylendiamintetraessigsaure, 14 Di-trichlorathylkarbonat 329 edetic acid) 20, 340, 355, 358 14 Diuretic action, reduction of 24 14 EE (AthynylOstradiol) 366 12 Diuretic agents 26 14 EEG synchronisation 241 14 - 48, 220, 243 12 Egg development 105 14 Diuretic activity 245 12 Egg transport 101, 108 13 Diviator 121 13 Egg-white 341, 348, 350 12 Divinyl ether 21 14 Eisena bsorption 357 12 Dixyrazin (Esucos) 201 14 Eisenkomplexe 357 12 DMSO (Dimethylsulfoxyd) 257, 258, 14 Eisentherapie 304 262 14 Eisenverbindung 304 12 DMSO, Indikationen 261 12 Ekilan 196 12 D:vISO, Nebenwirkungen 260 12 Elavil 208 15 DMT (Dimethyltryptamine) 72 1+ Electric eel 78 12 DNA synthesis 396 1+ Electron paramagnetic resonance (EPR) 12 DOC (Desoxycorticosterone) 332 68, 119 14 DOD (1,12-Dihydroxyoktadekan) 303 1+ Electrophoresis 66 12 Dolicur 262 12 Electrophysiology 335 15 DOM (2,5-Dimethoxy-4-methylamphe- 15 Electrostatic attraction 133 tamine) 72 13 Eledoisin 127 14 Donnan effect 65 12 Elektrophoresediagramm 178 15 DOPA (Dihydroxy-phenylalanine) 72 13 Eleodes longicollis 45 13 DOPA-decarboxylase inhibitors 108 13 Elephantin 13, 34 14 - 29 13 Elephantopin 13, 34 15 Dopamin 159 13 Ellipticine 33 13 Dopamine hydroxylase inhibitors 108 12 Elmedal 241 12 Dorsiflex 196 13 Emetine 48, 50, 51 13 Dosage 157 15 Emotion 94 15 Dosha 17, 19, 51 14 Emulgatoren 349 12 Dromisol 262 14 Emulsionssalben 353 12 Druck-Injektor 269 1+ Endarteriitis obliterans 306 14 Drug action 61 12 Endocarditis 406 15 - 126 15 - 42 15 Drug action, quantification of 341 13 Endochin 211 15 Drug action, reversibility of 345 12 Endocrine abnormalities 70 14 Drug antagonism 34 12 Endocrinology 139, 159 15 Drug combination 319,321,346 14 Endogenous corticoids 152 14 Drug, concen tra tion of 64 12 Endoxan 218, 220 15 - 277, 344, 346, 349 15 ENE (Ethylnorepinephrine) 107 13 Drug doses 160 12 Enovid® 150, 152 15 - 342 12 En teric fever 379 14 Drug-drug interactions 19 12 Enteritis 372 14 Drug interactions 12, 14 12 Enterobacteria 374, 381, 382, 384 15 - 326 15 Entgiftungsreaktionen 154 13 Drug latentiation 62 13 Envacar (Guanoxan) 114 14 Drug-macromolecular interactions 64 15 Enzyme 190 13 Drug metabolism 140, 150 13 Enzyme activity 140, 161, 162 14 Drug metabolism, inhibition of 32 14 - 85 13 Drug-metabolizing enzymes 141 12 Enzyme hyaluronidase 105 14 Drug-protein complex 73 14 Enzyme inhibition 61 15 Drug-receptor complex 131 12 Enzyme inhibitor 296 15 Drug-receptor interactions 137 14 - 33 12 Drug research 41, 48 14 Enzymes 91 12 Drug resistance 383 15 Enzyminduktoren 190 14 Drug transport 24 14 Eosin-B 361 15 - 129 15 Ephedrin 161 15 Dukkha Samyoga 15 13 Epiandrosterone 272 14 Duodenum 308 12 Epinephrine 14, 30 12 Duphaston® 151, 152 13 - 103 12 Durabolin® 143 1+ - 47, 90 15 Duracillin 43 ]3 trans-trans-10, 11-Epoxy-7-ethyl• 12 Dydrogesterone 151, 152 -3, 11-dimethyl-2, 6-tridccadienoa tc 13 Dystiscus marginalis 27 46 Index \-01. 12-15 363

14 EPR (Electron paramagnetic resonance) 12 Fertility, inhibition of 117 68 12 Fertilization 103 14 Equilibrium dialysis 68, 72 14 Fibrinogen 105 12 Ergokryptine 116 13 Fibrinolysin 357 13 Ergometrine 28 14 Fibrosarcoma 181 15 Ergosterol 212 14 Film, magensaitresistenter 29C 12 Ergotamine 324 ] 2 Flexartal 197 14 - 92 12 Flexin 198 12 Ergotoxine 116 1+ Flufenamate 214 14 Erythrocytes 116 14 Flufenamic acid 73 12 Erythromycin 18 12 Flufenaminsaure (Arlef) 262 15 - 215, 284, 295, 298, 315, 328 14 Fluokinolollazetonid 331 14 Erythromyzin 282, 296 15 Fluoracetat 176 14 Erythromyzin-Estolat 303 12 Fluoride supplements 14 14 Erythrosin 364 13 Fluoroacetic acid 165 13 Esbatal (Bethanidine) 111 13 Fluoroalkyl amines 143 14 Escherichia coli 481 13 D(-)-IX-Fluorocamphor 60 15 - 285, 342 15 5-Fluorodeoxyuridine 294 14 Esidrex® (Hydrochlorothiazid) 27R 13 5- Fluoronicotinic acid 226 12 Eskapar 208 1+ 61X- Fluoroprednisolone 173 14 Estradiol 123 12 5-Fluorouracil 17 15 - 212 15 - 294, 332 13 17/'l-Estradiol 231, 232 15 5- Fluorouridine 294 13 Estriol 231 1+ Fluoxymesterone 178, 184 15 - 212 14 Fluphenazine 117 14 Estrogen, radioactive ] 22 15 Flurothyl 220 13 Estrogens 225 ] 2 Folic acid 13, 394 13 Estrogens, nonsteroidal 234 15 - 212 13 Estrogens, steroidal 231 ] 2 Follicle stimulating hormone (FSH) 13 Estrone 231, 234 54, 154 15 - 212 12 Follicular extracts 113 12 Esucos 201 12 Follicular growth 53 12 Etalontin 150 12 Food and drug administration 38 12 Ethacrvnic acid 26 13 Forbisen 211 12 Ethaverin 347 12 Fosfocrisolo 230 12 E thchlorvvnol 22 15 Fremdstoffc 148 14 Ether 106- 12 Frenolon 312 12 Ethinamate 22 12 Friedlander's bacillus 419 13 17/'l-Ethinylestradiol 232 14 Fruktose 357 12 Ethinyl oestradiol 73, 75 ]2 FSH (Follicle stimulating hormone) 14 Ethionamid 369 53, 154 12 Ethisterone 77, 150 13 Fucoxanthin 44 14 Ethyl-biscoumacetate 26, 27 13 Fumagillin 17, 34, 39, 40 14 E th ylestrenol 173 13 Fungicides 39 13 3-Ethylidene-quinuclidine 305 14 Fungistatische Wirkung 480,48],484 14 Z-Ethyl-6-methyl-3-o-anisyl-4(3H)- 14 FUllgizide Wirkung 477 -quinazolone 222 15 Furadantin 49 15 Ethylnorepinephrine (ENE) 107 12 Furazolidone 112 14 Ethynylestradiol 124 13 Furazosin 124 14 17-Ethynylestradiol 122 13 Fusidic acid (Ramycin) 29, 33 12 Eugynon® 150 13 Eunicin 30 13 Galactose 359 13 E upachlorin acetate 34 14 Galaktose 357 13 Eutonyl (Pargyline) 109 14 Galenische Praparate 282 12 Extraartikulare Operationen 270 14 Galenische Technik 292 12 Extraartikularer Rheurnatismus 276 14 Gallensaure 355, 356 12 Gamaquil 190, 197 12 Fagara coco 329 12 Gammacorten 253 14 Falcarinon 526 14 Ganglienblocker 468 13 Farnesinic acid 263 14 Ganglienblockierende Wirkung 43C 13 Farnesinic acid analogs 263, 264 13 Ganglion-blocking activity 3] 8, 322, 13 Farnesol 42 323, 324, 325, 328 13 trans-trans-Farnesol 46 13 Ganglion-blocking agent 331 13 Farnesylacetic acid 37 15 Ganglionic blockade 252 13 Farnesylacetic acid, basic ester of Cl 14 Gangliosides 89, 9C 13 Farnesyl-p-aminobenzoate 61 12 Gantanol (Sulphamcthoxazole) 383 13 Farnesyl pyrophosphate 259 13 Gastric ulcers 34 14 Febrifugine 219, 220, 221, 225 14 Gastric lavage 20 12 Febris rheumatica 172, 234, 272 14 Gastric ulcers 176 13 Felinine 261 12 Gastro-ellteritis 385 13 Ferredoxin 67 1+ Gastrointestinal-Erkranlmngen 439 364 Index Yo!. 12-15

12 Gastro-intestinal system 25 13 Guanoclor (Vatensol) 115 13 Gefarnate 34, 36, 37 13 Guanoctine 110 14 Gelatinekapseln 292, 356 13 Guanoxan (Envacar) 114 14 Gelatinesteckkapseln 285 13 Guanoxyfen 114 12 Gelenkerkrankungen 168 13 Guanyl-benzoxazepine 112 12 Gelenkknorpelextrakte 263 12 Gelenkoperationen 270 12 Haemophilus injluenzae 419 14 Gel fiUra tion 66 14 Haemorrhagic shock 205 13 Gelsemicine 50 15 Halbwertszeit 182 13 Gelsemine 50 12 Half-life time 397, 421, 422, 428, 431, 13 Genepin 21 435, 449 13 Genipa americana L. 43 14 - 13,27 13 Genipic acid 43 14 Half-life time, prolongation of 30 12 Gentamicin 382 14 Half-life time, shortening of 29 15 Gentamycin 215 15 Hallucination 93 13 Gentiana scabra Bunge 21 15 Hallucinogenic agent 76 13 Geosmin 16 15 Hallucinogens 85 13 Geranyl pyrophosphate 259 14 I-Halogen-alkin (1)-en-(4)-0Ie-(3) 415 14 Geschmack 292 14 I-Halogen-alkin-(1)-0Ie-(3) 414 12 Gestanon® 150 12 Haloperidol 23, 201 15 Gewebe, Depots 148 14 - 118 12 Gicht 169, 280 12 Halothan(e) 21 12 Gichtanfalle 284 14 - 106, 107 12 Gich ta ttacke 282 15 - 176 12 Gichtdiat 285 15 Hansch equation 124 12 Gichttophi 285 13 Hansolar® 193, 195 13 Glaucarubin 39 12 Harnsaurebildung 288 13 Glaucarubinone 15 12 Harnsauregicht 280 13 Glaucoma 310 14 Harnstoff 345 14 Gliadin 94 14 Harnweginfektionen 298 14 ex2-Globulin 203 12 HCG (Human chorionic gonado• 14 y-Globulin 105 trophin) 53, 97, 154 14 Glucocorticoids 140, 150, 171 14 Heart cells 100 12 Glucophage® 158 12 Heart extracts 334 13 Glucose 359, 360, 361 14 Heat shock 202, 204 14 - 199, 204, 208, 357 14 H edera helix L. 517 13 Glucosuria 361 12 Heilanasthesie 266, 267 15 Glucuronidbildung 180 14 Helenynolsaure 520, 527 15 Glucuronide 163 13 Heliangin 12,66 14 D-Glukose 354 13 H elianthus tuberosus L. 66 15 Glukoseabbau 172 13 Helminthosporium sativum 14 12 Glutethimide 22 13 Helvolic acid 29, 30, 33 14 - 366 15 Hemmstoffe 195 15 - 189 l4 Hemodialysis 23, 24 12 Glycodiazin (Redul®) 157 14 Hemoglobin 22, 107 13 Glycolysis 358 14 Hemoperfusion 24 13 Glycoside conjugation 147 13 Heparin 358 13 Glycyrrhetic acid 35 l4 - 22, 87, 93, 94, 96, 104, 352 13 Glycyrrhetinic acid (Glycyrrhetic acid) 14 Hepatic cirrhosis 179 35, 59,60 13 Hepatic enzymes 266 12 Glyketal 197 13 Hepatotoxic agents 267 l4 Glykodiazin 332 12 Herdinfektion 216 12 Goldpraparate 221 15 Herzglykoside 184 13 Gonadal hormones 273 12 H etacillin 380 12 Gonadotrophins 60, 73, 76, 153 13 Heteroquinine 20 12 Gonadotrophins, effects of 57 13 ex, ex, ex, ex', ex', ex' -Hexachloro-p-xylene 176 12 Gonococci 406 14 Hexadiin-(2,5)-01-(I) 391 15 Gopaniya 35 14 2-Hexadiin-(2, 4)-yliden-l, 6-dioxaspiro• 15 Gorgosterol 266 (4,4)-nonen-(3) 519 14 Gradumet® 296 12 Hexamethonium 28 13 Granulocytopaenia 31 14 Hexatriin-(I, 3, 5) 521 13 Grifolin 17 13 Hexestrol 234, 260 12 Griseofulvin 19 14 - 122, 124 14 - 324, 367 14 Hexin-(5)-saurehydrazid 452 13 S-Guaiazulene 34 13 Hexobarbital 161 13 Guanacline 116 14 - 25 13 Guancydine 117 13 Hexobarbital, half-life of 161 12 Guanethidine 28, 325 12 Hexobendin (ST-7090, Ustimon) 330 13 - 110, 111, 230 12 Hexoestrol 74 14 - 24 13 H.H-197 (Sinecoid) 248 13 Guanisoquine 112 14 Hilfsstoffe 336, 356 Index Vol. 12-15 365

13 Histamine 354, 358 13 3-Hydroxyquinuclidine, carbaminic 14 - 35, 43, 92, 94, 199, 204, 213 esters of 312 12 HMG (Human postmenopausal 13 3-Hydroxyquinuclidine esters gonadotrophin) 55 294, 302, 306, 320 14 Homeostasis 24 13 5-Hydroxytryptamine 352, 355, 358 12 Hormonapplikation 256 14 - 198, 199, 204, 206, 213 12 Hormone 140 14 Hydroxyzine 118 12 Hormone action 140 15 H yperacusis 93 13 Hormones 362 14 Hyperaldolasemia 150 14 - 47, 179 14 Hypercalcuria 168 15 Hospi tals 38 l3 Hypercholesterolemia 278 12 Hostacortin 252 15 Hyperexia 40 12 HPFSH (FSH extract of human 13 Hyperglycaemia 361 pituitaries) 58 14 Hyperglycemia 151 14 HSA (Human serum albumin) 96 12 Hyperkortisonismus 254 13 HT-1479 (Ansiv) 121 13 Hyperlipemia 232 15 5-HT (Serotonin) 75 13 Hyperlipemic disorders, classification of 13 5-HT, inhibitors of 355 224 12 Human pituitaries, FSH extract of 13 Hyperlipidemia 220, 222, 257, 278 (HPFSH) 58 12 Hyperplasia, endometrial 67 12 Human postmenopausal gonatrophin 15 Hyperpyrexia 39 (HMG) 55, 154 13 Hyperstat (Diazoxide) 125 Human serum albumin (HSA) 96 12 Hypertension 28 12 Hyadur 262 13 - 315 14 Hyaluronic acid 85 13 Hypertensive disease 325 13 Hyaluronidase 349 14 Hypnotic action 228 14 - 369 14 Hypnotic agent 220, 226, 233, 236, 241 15 Hycanthone 218 14 Hypnotikum 392, 394, 399 14 Hydantoin 403, 425 14 Hypnotische Wirkung 393, 400, 390, 12 Hydergine 324, 338 391 12 Hydralazine 28 13 Hypocalciuric effect 30 12 Hvdro-Adreson 252 13 Hypocholesterolemic agent 12 Hydrobutamine (Butadrine, Recetan, 237, 239, 251, 262, 265 Simes CO 405) 349 12 Hypoglycaemia 157 Hydrochlorothiazid(e) 278, 364 13 Hypoglycaemic activity 50 15 - 219 15 Hypoglyzin 178 12 H vdrocortifor 252 13 Hypolipemic agent 229 12 Hydrocortison 140, 252 13 Hypolipidemic activity 228, 247 12 Hydrocortone 252 13 Hypophysectomy 364 12 Hydrocuprein 303 12 Hypopotassaemia 342 15 Hydrogen bonding 133 13 Hypotension 57 14 Hydrokortison 356 14 Hypotensiva 469 13 Hydrolysis 146 13 Hypotensive activity 317 15 Hydrophobic bonding 133 13 Hypotensive agent 28 15 Hydrophobicity 130 14 Hypotensive Wirkung 451, 467 14 Hydrotropie 341 12 Hypothermia 347 12 Hydroxizine (Atarax) 83, 191, 311 14 Hypothermic activity 227, 236 12 Hydroxychloroquinsulfat (Plaquenil) 232 13 Hypothyroidism 241 14 17-Hydroxycorticosteroids 168 12 Hypoxanthin 287 13 5-Hydroxy-dopa 106 13 6-Hydroxydopamine 106 13 Ibogaine 24, 56, 60 13 20-Hydroxyecdysone (Crustecdysone) 27 14 Ichthyotherol 527 13 3-({J-Hydroxyethyl)-quinuclidine 14 ICSH (Inhibition of gonadotropin esters 310 secretion) 162 12 4-(2-Hydroxy-3-isopropylamino• 13 Icterogenin 65 propoxy)-indol (LB-46) 349 12 Idiosynkrasie 236 15 - 114 15 Ikterus 191 14 Hydroxylation 25 13 Illicium religiosum 65 13 N-Hydroxylation 145 13 Illudin S (Lampterol) 33 15 Hydroxylierung 153 15 2-(4-Imidazolyl)-cyclopropylamine 234 15 N-Hydroxylierung 170 13 2,3-Iminosqualene 39 13 3-Hydroxy-3-methylglutaric acid 261 12 Imipramin(e) (Tofranil) 207, 316 13 {J-Hydroxy-{J-methylglutaryl reductase 14 - 18, 24, 31, 92, 113, 114 246 15 - 157 13 21-Hydroxypregn-4-en-3,20-dione 27 12 Imotryl 263 14 14-Hydroxy-N-propin-(2)-yl• 12 Implantation inhibitor 115 dihydronormorphinon 456 13 IMPO (Isopropylmyristete peanut oil) 14 8-Hydroxy-4-quinazolone 259 174 14 8-Hydroxyquinoline 21, 22 12 Imuran 218, 220 13 3-Hydroxyquinuclidine arylaliphatic 15 - 217 acids esters 317 12 Imurel 220 366 Index Vol. 12-15

14 INAH (Isonicotinic acid hydrazide) 46 12 Isopropylmethoxamine 323 13 2-(4-Indanoxy)-butyric acid 252 13 Isopropyl myristate 174 12 Inderal (Propranolol) 322, 338 12 Isoproterenol 319 13 - 119 14 - 90 15 Indian medicine 21 12 Isoptin 348 12 Indocid 283 12 Isopyrin 241 13 Indoles 123 12 Isthmus 109 12 Indomethacin (Indocid) 23, 31, 247, 283 12 Istonil 197 15 - 220, 221 12 Infarction 95, 371 13 Jalaric acid A 45 14 Infection, pneumococcal 183 15 Jaundice 39 12 Infections, treatment of 384 14 Junipal 483, 528 12 Infectious diseases 410,414,417, 13 Juvabione (Methyl todomatuate) 47 418,421 13 Juvenile hormone 46,66 12 Infertility 108, 117 13 Juvenile hormone activity 46,47 12 Infiltrina 262 12 Influenza 19 14 Kalium-Glukonat 300 15 INH (Isonikotinsaurehydrazid) 154 13 Kallidin 127 14 Inhalationsnarkotikum 389 15 - 216 14 Inhibition of gonadotropin secretion 13 Kallidin-9 356 (ICSH) 162 14 Kallikrein, inhibitor of 215 14 Inkompatibilitat 335 12 KalteschutzmiUel 258 12 INPEA (N-isopropyl-p-nitrophenyl- 12 Kanamycin 19, 376, 385 ethanolamine) 323, 348 14 Kanamyzin 355 13 - 119 14 Kaopectate® 19, 365 14 - 38 15 Kapha 61 15 - 108 15 Kaphaic diseases 62 13 Insect attractants 41 15 Kaphaic drug 18 13 Insecticide 40 14 Karbazochrom 360 13 Insect repellents 42 14 Karboxymethylzellulose (CMC) 12 Insidon 207 303, 343, 362 15 Insomnia 45 14 {J-Karotin 367 12 Insulin 14 15 Keeson interactions 134 13 - 361,364 12 Kefauver, Estes 37 14 - 47, 290 12 Keflin (Cephalothin) 381 12 Insulin preparations 156 12 Kenacort 253 14 Intentionstremor 428 12 Ketocaine (Compound Rec 7-0518) 332 15 Interferon 222 14 2-Keto-4-quinazolone 247 12 International reference preparation 13 3-Ketoquinuclidine-2-ethyl carboxylate (IRP) 60 299 12 Intestinal infections 379 12 Kinarosyl 196 12 Invalidisierungsgefahr 180 14 Kinin 199 13 3-Iodotyrosine 107 14 Kininase activity 200 15 Ion-dipole interactions 133 14 Kininase enzyme 203 12 Ipecacuanha 339 14 Kininogen 214 13 Ipecacuanha alkaloids 18, 21, 24, 50 14 Klathrate 344 15 Ipomoea violacea 74 12 Klebsiella 371, 372, 386 12 Iproniazid(e) 115, 316 12 Klebsiella aerogenes 386 13 - 109,178 12 Klebsiella pneumoniae 19, 427 15 - 159, 194, 220 12 Knochenmarkextrakt 263 12 Iproveratril 323 14 Ko 592 (1-(3-Methylphenoxy)-2- 13 Ips con/usus 42 hydroxy-3-isopropylaminopropane) 38 12 Irgapyrin 283 15 - 112 13 lridodial 43, 44 14 Kobalt 359 13 Iridomyrmecin 43,44 14 Koffein 360, 361 12 Iromin 238 12 Ko1chizin 283 12 IRP (International reference 12 Kollagenkrankheiten 171 preparation) 60 14 Kompatibilitat 334 12 Isocarboxazid (Marplan) 24, 208 14 Komplexe, aquimolare 359 14 Isofebrifugine 220 14 Komplexgleichgewichte 345 14 Isomycomycin 520, 528 14 Komplexverbindnngen 337 14 Isonemotinsaurelacton 529 12 Kortikosteroide 250, 254, 283 12 Isoniazid 19 12 Kortikosteroideffekte 251 14 - 92,352 12 Kortikosteroidtherapie 255, 257 15 - 159, 220 12 Kortikotropin 250, 254, 283 14 Isoniazid-p-amino-salizylat 299 12 Kortisol (Cortef, Cortril, Hydro• 14 Isonicotinic acid hydrazide (INAH) 46 Adreson, H ydrocortifor, Hydrocortisone, 15 Isonikotinsaure 159 H ydrocortison, H ydrocortone, 15 Isonikotinsaurehydrazid (INH) 154 Scheroson F) 252 14 5-Isopropylbarbitursaure-Derivate 402 12 Kortison (Adreson, Cortifor, Cortison, 13 3'-Isopropyl-3, 5-diiodothyronine 244 Cortone, Scheroson) 246, 250, 252 Index Val. 12-15 367

14 Kortisanazetat 314, 319 14 Local anesthetics 108 12 Krizanol 229 13 Lochnerine 33 12 Krysolgan 229 13 Locke's solution 359 12 Kupfertherapie 230 13 Loganin 20, 21 14 Kustrin® 141, 182 14 Lokalanasthetische Wirkung 403, 437, 438 14 LA (Lysergic acid monoethylamide) 115 15 London interactions 134 15 Lability 94 15 Lophophora williamsii 72 13 Laccifer lacca Kerr 45 12 Lopion 229 14 Lachnophyllumester 527 14 Loslichkeitsunterschied 311 15 Lactobacillic acid 261 14 Losungsgeschwindigkeit 319 13 Lactobacillus acidophilus 260 14 LSD (D-Lysergic acid diethylamide) 15 Lactobacillus arabinosus 260 96, 114, 115 15 Lag time 310 15 - 71, 74 13 Lampterol 33 15 LSD, metabolism of 89 13 Lanosterol 33, 259 15 LSD, pharmacology of 86 13 Lantadene A 65 15 LSD, psychophysiology of 91 12 Largactil (Chlorpromazin) 199 15 LSD, psychological effects of 92 12 Larocaine 308 15 LSD, radioactive 90 12 Laroxyl 208 15 Lucanthone 218 14 Laryngitis 182 15 Luminal 182 12 Lauron 229 12 Lumirelax 196 14 Laxan 299 12 Luteinizing hormone (LH) 54, 154 12 LB-46 [4-(2-Hydroxy-3-isopropyl• 12 Lyndiol® 150 aminopropoxy)-indoIJ 349 12 Lynestrenol (Orgametril®) 77, 79, 150 15 - 114 14 Lynkomyzin 370 15 Leber 149 12 Lyseen 197 15 Lebermikrosomen 153 15 Lysergic acid 217 15 Leberzirrhosen 185 14 D-Lysergic acid diethylamide (LSD) 14 Leci thin 11 0 96, 114, 115 12 Ledercort 253 15 - 71, 74 13 Leishmania braziliensis 188 14 Lysergic acid monoethylamide (LA) 115 13 Leishmania mexicana 188 14 Lysolezithin 354 13 Leishmania tropica 188 14 Lysosomal enzymes 116 13 Leniquinsin 124 13 Lysozyme 344 12 Leprosy 421 12 Lysyl-vasopressine 333, 334 14 Leptazol® 229 13 Leron 116 13 MA-1277 (Zolertine) 122 14 Leukemia 181 14 Macromolecule, concentration of 67 12 Leukeran 218, 220 14 Macromolecules 69, 70 12 Leukocyte count 446 13 MADDS (4'-SuJfanilylacetanilide) 12 Leukocyte excretion 444 197, 201 14 Leukozytose 478 14 Magen-Darm-Blutungen 334 13 Leurocristine (Vincristine) 31 14 :\1agen-Darm-Kanal 288 13 Leurosidine (Vinrosidine) 32 14 :\fagenpassage 288, 289 13 Leurosine (Vinleurosine) 32 14 Magenschleimhaut, Lasionen der 29R 12 Levomeprornazin(e) (Minozinan, 14 Magnesium oxide 20 Neurocil, i\1ozinan) 200 12 Magnesium sulfate 336 14 - 118 15 Makaradhwaja 19 12 Levorphanol 21 14 Makromolekiile 343, 362 13 - 145 15 Malaoxon 155 12 LH (Luteinizing hormone) 54, 154 12 Malaria 20 12 Librium 191 13 Malaria chemotherapy 171 12 Lidocaine 307, 346 15 Malathion 155 14 - 109 15 Malvalic acid 263 13 Limonene 44 15 Manasika 16 12 Linaxar 198 12 Mantomide 20 14 Lincomycin 45, 308, 365 14 Manucol® 278 15 - 284, 295, 298, 328 14 MAO (Monoaminaaxidase) 115, 449 15 Lincosaminide antibiotics 315 14 MAO-Hemmer 449,451 14 Lipid metabolism 151 12 MAO I (Monoamine oxidase inhibitors) 13 Lipid mobilization, inhibitors of 230 24, 115 13 Lipids 126 14 - 115, 257 14 - 89 15 MAO inhibitory activity 238, 247 15 Lipophilicity 129 15 MAO inhibitory mechanism 241 13 oc- Lipoprotein 223 12 MAP (Medroxyprogesterone-acetate, 13 fJ- Lipoprotein 223 Provera®) 78, 151 13 Li poproteins 220 14 Marasin 529 12 Liposolubility 428, 431, 439 14 (-)-Marasin 521 12 Lissephen 196 13 Marasmic acid 33 12 Local anesthetics 303 15 Marihuana 79 368 Index Vol. 12-15

14 Markennamen 276, 277 14 Mescaline 92, 115 12 Marplan (Quarzanbromide) 208 15 - 76 13 - 318 13 Mesoinositol hexanicotinate 227 13 Mast cells 358 12 Mesterolone (ProvironMeclizine 119 12 Metaraminol 319, 320 14 Meclofenamate 208,214 13 - 106 14 Meclofenamic acid 73 14 Metastases 181 12 Medicinal Chemistry 12 12 Metaxalone 22 12 Medrol 253 15 Methacycline 215 12 Medron 253 12 Methadone 21 12 Medroxyprogesterone-acetate 14 - 225 (MAP, ProveraMefenamic acid (Mefenaminsaure, 12 Methamphetamin(e) 24 Parkemed, Ponstan) 22,262 15 - 161 14 - 73 14 Methandriol 314 12 Mefenaminsaure 262 13 Methandrostenolone 273, 274 12 Megestrol 78, 151 14 - 150, 155, 160, 165, 166, 168, 169, 12 Melaminsulfon-Na (Melubrin) 241 173,174,175,176 14 Melanin 119 12 Methapyrilen(e) 310 13 Melia azadirachta L. 15 14 - 303 13 Melia azedarach L. 15 14 Methaqualone 220, 233, 234, 238, 241 13 Meliantriol 15 14 Methaqualone, metabolism 242 12 Mellaril 312 12 Methaxalone (Skelaxin) 196 12 Melleril 200 14 Methemoglobin 22 12 Melubrin 241 12 Methenolone acetate 145 14 Membran 346 14 - 150,177 12 Membranpermeabilitat 259 14 Methenolone enanthate 170, 171 12 Menadione (Vitamin K.) 27 12 Methicillin 371 14 - 362 14 Methizillin 296 12 Meningitis 372, 386, 392 12 Methocarbamol (Lumirelax, 12 Menstrual cycles 93 Neuraxin, Robaxin) 196 13 Mental diseases 315 12 Methophenazine (Frenolon) 312 13 M enyanthes trifoliata 21 13 Methoserpidine 28 12 Mepazin (Pacatal) 200 12 Methotrexate 218, 221 12 Meperidine 21 12 Methotrimeprazine 22 14 - 18 12 Methoxamine 319, 320, 323, 340 12 Mephenamin 198 13 4-Methoxy-3,5-dihydroxy- 12 Mephenesin (Decontractyl, Lissephen, phenylalanine 106 Myanesin, Relaxar, Toiseron) 196 12 Methoxydone (Dorsiflex, Ekilan, 12 Mephenesincarbamat (Kinarosyl, Mephenoxalone, Trepidon) 196 Toiseram) 196 12 Methoxyflurane 21 12 Mephenoxalone 196 14 - 106 12 Mephentermine 319, 320 14 6-Methoxy-2-mercapto-quinazolones 251 15 Mephobarbital 155, 156 12 Methprylon 22 14 Mepivacaine 109 14 1-Methyl-5-allyl-5-(1-methylpentin- 12 Meprobamat(e) (Aneural, Cyrpon, (2)-yl)-barbitursaure 402 Miltown, Pertranquil) 23, 83, 190, 311 12 Methylaminopterin (Amethopterin, 13 - 141 Methotrexate) 17, 218, 221 14 - 113 14 2-Methyl-3-aminoquinazolone 235 15 - 185 14 Methylandrostenediol 154, 163, 164, 14 Mepyramine 209 165, 182 12 MER-29 (Triparanol) 69 14 2-Methyl-3-aryl-4-oxo-1,2,3,4- 13 - 235,236 tetrahydroquinazoline 254 12 6-Mercaptopurin(e) 17 14 2-Methyl-3-aryl-4-quinazolones 236 15 - 150 13 Methylations 149 14 2-Mercapto-4-quinazolones 250 14 4-Methyl-4-athyl-1-(propin-(2)-yl)• 15 6-Mercaptotrimethoprim 217 piperidindion-(2,6) 404 Index Vol. 12-15 369

1+ 2-Methyl-3-(4-bellzhydrazide)-4- 14 3-:Vlethyl-4-(3H)-quinazolone 256 quillazolone 257 13 4-Methylquinuclidine 295 13 6-Methyl-3-benzoyloxyquilludidine 31(i 14 :vrethyltestosterone 154, 178 ] 3 7-Methyl-oc-bisdehydrodoisYllolic acid 14 2-Methyl-3-(o-tolyl)-6-chloro-4-(3H)- 234 -quinazolone 238 14 2-Methyl-3-(4'-bromophcllyl)-4- 14 2-Methyl-3-(o-tolyl)+ quillazolone 229, 234 quinazolone 227, 228 14 2-Methyl-3-(o-bromophellyl)-4-quilla- 14 2-Methyl-3(2' -trifluoromethylphl'nyl)- zolone 237 -4-quinazolonc 236 13 2-Methyl-2-blltenecarboxylic acid 262 13 oc-Methyltyrosine 106, 107 15 2-Methyl-2-(carbamoylmethyl)pentyl 14 Methylzellulose (MZ) 362 ill -cyclopropylcarbamate 248 13 :vrcthysergide 38, 39 14 2-Methyl-6-chloro-4-quinazolone 247 14 - 209 14 Methylchlorpromazine 114 12 :Vleticortelone 252 12 Methyl cholanthrene 113 12 ~Ieticorten 252 14 2-Methyl-3-cydohexyl-4- 12 :Vletoclopramide (Plasil) 34b quinazolone 236 14 :VIetrazol® 227, 235 13 :\Iethyldopa 104 12 Metronidazole 21 12 oc-Methyl-DOPA 28 13 :vretyrapon(e) 267 14 - 29 15 - 170,194 13 DL-oc-Methyldopa 104 13 ~Ievalonic acid 258, 260 15 24-Methylenecycloartanol 260 15 - 222 15 3,4-Methylenedioxyamphetamilll' 13 Mevalonic acid analogs 261 (MDA) 72 13 Mevalonic acid pyrophosphat 259 13 3-Methylene-quinuclidines 303 14 Meyer-Overton theory 105 13 ~[ethyl-tra1ts-trans-lO, 11- 15 :vue (Minimum inhibitory epoxyfarnesate 46 concentration) 139, 275 14 17-:lTethylesteradiol 122 15 Microbial generation 276, 283, 290, 301 13 4-Methylestra-1, 3, 5(10)-trien- 15 Microbial kinetics 275, 307, 311, 315 17-one 232 15 Microbial kinetics, advantages of 34R 1.3 6-Methylhept-5-en-2-one 44 15 Microbiological analysis 273 13 4-Methylhexan-2-one 44 12 Microelectrode technique 335 14 3-Methyl-6-hydroxy-2,4-(IH,3J-l)- 12 Microorganisms 416 quinazolinedione 255 15 Microorganisms, concentration of 27R 14 2-Methyl-3-isobutyl-4-quillazolone 235 14 Microsomal proteins 81 13 3-Methylisoxazole-5-carboxylic acid 229 14 Midbrain 97 14 2-Methyl-3-(p-methoxyphenyl)- 14 :VIikromahlung 331 -4-quinazolone 225 15 :VIikrosomenfermente 182 14 2-Methyl-8-methoxy-4-quinazolone 2.i(J 15 Mikrosomenfraktion 152 13 (+ )-2-Methyl-6-methylen-2, 7- 15 Mikrosomensuspensionen 153 -octadien-4-o1 41 12 Millicorten 253 13 (- )-2-Methyl-6-methylen-7-octell• 12 Miltown 190 -4-01 41 15 Minimum inhibitory concentration 13 4-:vrethyl-mevalonic acid 261 (MIC) 139, 275 13 oc-Methylnorepincphrine 105 14 Minor analgesic agcn ts 70 12 17oc-Methyl-19-nortestosterone 7(), 77 12 Minor chemotherapy 416 12 Methylparafynol 22 12 Minozinan 200 14 3-Methylpentin-(1)-ol-(3) 393, 394, 400 14 Miracil D 32 14 3-Methylpentin(1)-ol-(3)-carbamat, 13 Mi tosis 32 Derivate 411 14 Mixturen 286 14 3-Methylpentin-(1)-ol-(3), Ester 410 14 Mizellen 348 14 Methylphenobarbital 32 12 MJ 1999 (Sotalol) 322 14 1-(3-Methylphenoxy)-2-hydroxy- 13 - 119 -3-isopropylaminopropane (Ko 592) 38 13 MK-485 (N-Amino-methyldopa) 105 15 - 112 12 :VILA (Musculus levator ani) 142 13 3-Methyl-4-phenyl-3-butenoic 12 MLA Test 144 acid amide 248 12 Mogadon 191 12 :VIethylprednisolon, (Medrol, Mcdron, 14 Molecular structure 70 Suprametil, Urbason) 253 14 Molekiilkomplexe 341, 342 14 - 313 14 Monoamine oxidase (MAO) 115, 210 14 6oc-Methylprednisolone 125 15 Monoamine oxidase, inhibition 230 14 N-Methyl-N-propin-(2)-yl- 12 Monoamine oxidase inhibitors -aminoindan 451 (MAOI) 115, 347 14 N-Methyl-N-propin-(2)- 13 - 109 -ylbenzylamin 449 14 - 257 14 3cMethyl-1-propin-(2)-yl- 14 Monoaminooxidase (MAO) 449 -3-benzyl-diaziridin 452 13 Monocoenzymc A 258 14 2-Methyl-1-propin-(2)-yl-cyclopcntanol- 12 :vronophenylbntazon 241 -(1) 397 13 Monosaccharides 359 13 5-Methylpyrazole-3-carboxylic acid 229 13 :vronotropeine ester 21 14 2-Methyl-3-(2-pyridyl)-quinazolone 261 14 :Vlontmorillonit 365

24 Jucker 15 370 Index Yo!. 12-15

12 1\lorphine 21 12 Neo-Antergan 310 13 160 12 Neoarsphenamine 17 14 - 116,225 12 Neoflex 198 15 - 157, 190 12 Neo-hetramine 310 12 MRL-41 (Clomiphene) 56 12 ;\ieomycin 19, 376 15 L-( + )-Muscarine 251 14 - 103,355 13 Muscle relaxant 329 15 Keomycin A 215 15 Muscle relaxant activity 248 14 Keopasalate® 306 12 Musculus levator ani (MLA) 142 14 Neoplasm 180 12 Muskelrelaxantien 195, 196 14 Neoplasm inhibitor 260 14 - 438 14 Neostigmin(e) 43, 77 12 Muskelrelaxation 193 15 - 157 14 Mutterkornalkaloide 361 13 Keoxanthin 44 13 MV A (Mevalonic acid) 258 13 N epeta cateria 42 12 Myanesin 196 13 Nepetalactone 42 13 Mycobacterium tuberculosis 30 13 N erolidol 46 14 - 249, 520 14 ;\ierve proteins 82 15 - 261 15 Nervous breakdown 45 15 Mycolic acids 261 12 Nethalide 322 14 Mycomycin 478 14 Netzmittel 349 12 Myleran 53 14 Neuraminic acid 118 12 Myocardial infarction 341 14 Neuraminidase 89 12 Myocardial membrane 29+ 12 Neuraxin 196 12 Myocardium 294 12 Neurocil 200 12 Myochrysin 229 13 Neurodermatitis 345 12 Myocrisin 229 14 Neurokeratin 115 14 Myoglobin 106 12 Neuroleptics 311 12 Myometrium 148 12 Neuroleptika 190, 198 12 Mvoral 229 12 Keuroleptika, Nebenerscheinungen 203 12 Myordil 317 12 Neuromuscular blocking agents 31 13 - 235 12 Neuron-blocking agents 325 14 Myosin B 91 13 Neuroses 315 12 Myotomien 271 12 Neurotomien 271 15 Myristica jragans 73 14 Neurotropic agen ts 109 14 Mvristinsaure 289 12 New Drugs 35 14 MZ (Methylzellulose) 3(,2 12 Niacinamide 13 12 Kialamid(e) (Niamid) 24, 115, 208, 315 12 Nadisan® 157 13 - 276 12 NADPH 70, 72 12 Niamid 208 12 Na.EDTA (Sodium ethylendiamilH' 13 Nicotinic acid 225 tetraacetate) 336 13 Nicotinic acid amide 228 12 Nafoxidine (U-11100A) 56, 72 13 Kicotinic acid, esters of 227 13 - 240 13 Nicotinic acid, N-oxide of 226 14 Nalidixic acid 18 12 Nilevar® 145 14 Nandrolone 143, 177 12 Kitrazepam (Mogadon) 191 14 Nandrolone phenylpropionate 14 Nitrofurantoin 298, 299, 333 144, 145, 149, 150, 151, 155, 162, 166, 1+ N-(5-Nitro-2-furfurylidene)- 168, 17~ 171, 172, 17~ 18~ 183. -2-methyl-3-amino-4-quinazolone 259 13 Naphazoline (Privine) 118 14 Nitrogen mustards 104 13 Naphthylacetic acids 251 12 Nitroglycerin 27 15 2-Naphthylamin 173 13 Nitro-reductase 145 13 ~-(l-Naphthyl)-butyric acid 251 12 Nivaquine 232 14 Narcosis 107 14 NMR (Nuclear magnetic resonance) G9 12 N ardil 208 12 Nobamide 306 14 Narkotikum 402 12 Noduli rhcllmatici 170 14 Narkotische Wirkung 389, 391 14 Nonatriin-(2, 5, 8)-01-(1) 391 13 Nasivin (Oxymetazoline) 118 14 Nonident P42® 319 13 Nasopharynx 34 12 Noracyclin® 150 13 N asutitermes exitosus 42 12 Noradrenaline 319, 339, 340 14 Na-TDC (Natriumtaurodeoxycholat) 355 14 - 209,210 14 Natriumlaurylsulfat 356 14 Norandrosteron 172 12 Natriumsalizylat 234, 238 14 Norandrosterone phcnylpropionate 164 14 Natriumtaurodeoxvcholat 14 N"orbe1ethone 149 (Na-TDC) 355 . 15 Norephedrin 161 14 N a tri uresis 244 13 Norepinephrine 103 12 Natriuretic agents 26 14 - 35, 90, 91 14 Nebenwirkungen 296 12 Norethandrolonc 76, 77, 83 14 Nematozide Wirkung 390, 396 14 - 142, 154, 155, 158, 165, 168, 169, 14 Nemotin 521, 528 170,171,174,177 14 Nemotin A 521, 529 12 Norethindrone (Norethisteronc) 76, 77, 14 Nemotinsiillre 528 85, 88, 150 Index Vol. 12-15 371

12 Norethisteronc (Norethindrone) 150 12 Oral contraceptive, action of 97 12 Norethynodrel 76, 77, 83, 86, 97, 150, 12 Oral contraceptives 152 152 12 Orgabolin® 145 12 Norfiex 198 12 Orgametril (Lynestrenol®) 150 12 Norgestrel 77, 79, 150 12 Orinase® 157 12 Norinyl® 150 12 Oronol 230 12 Noritren 208 12 Orosan 229 13 Norlupinane 294 12 Orphenadril 198 14 Normaltropfenziihler 287 12 Orphenadrin(e) (Disipal, Mephenamin, 12 Norpramin 207 Norfiex, Orphenadril) 198 12 19-Norprogesterone 78 14 - 119 12 19-Nortestosterone 77 12 Osteoarthronotische Manifestationen 275 14 - 164,170 12 Osteomyotomien 271 12 N ortrilen 208 14 Osteoporosis 168, 171, 172 12 Nortriptylin (Aventyl, Noriten, 12 Osteotomien 271 Nortrilen, Sensival) 208 13 Otrivin (Xylometazoline) 118 13 Nosema infections 40 14 Ouabain 98 12 Novachrysin 229 13 Ovalbumin 342 12 Novalgin 241 12 Ovarian disease, polycystic 69 12 Novamidon 240 12 Ovarian dysfunction 63 12 Novaminsulfon-Na 241 12 Ovarian hormones 115 12 Novdimal 306 12 Ovarian hyperstimulation 61, 64 12 Noveril 208 12 Ovarian overstimulation 62 13 Novobiocin 157 12 Ovarian stimulation 65 15 - 215 12 Ovariectomy 109 12 Novum® 150 12 Oviduct 109 12 Nozinan 200 13 Ovoglobulin 345 14 Nuclear magnetic resonance (NMR) 69 13 Ovomucin 345 14 Nucleic acids 88, 102, 104 13 Ovomucoid 342, 348, 351, 359 12 N upercaine 308 12 Ovulation, induction of 54 13 N upharine 50 12 Ovulation, inhibition of 75, 85, 101, 151 15 Nursing 38 12 Ovulation inhibitor 78 15 Nystatin 215 12 Ovum, nidation of 148 13 Oxandrolone 274 14 OAD (l,2ot-Oxydoandrostan-3,17- 14 - 149 -dione) 184 13 N-(3-0xapentamethylene)·N', N"• 14 OADD (l,2ot-Oxydo-4,6- -diethylenethiophosphoramide 144 -androstadien-3,17-dione) 185 15 Oxazepam 157 13 t-Octylguanidine (Guanoctine) 110 15 Oxedrin (p-Sympatol) 161 14 Odyssin 521, 529 14 5-0xo-heptin-(6)·siiureiithylester 474 14 Odyssinsiiure 521, 529 15 Oxophenarsin 164 13 Oedema 352 14 1-(2'-Oxopyrrolidino)-4-pyrrolidino• 14 - 214 ·butin-(2) 428 14 Oenanthotoxin 518, 526 14 4·0xoquinazolyl-2-mercaptoacetic 12 Oestradiol 74, 80 acid 251 12 Oestradiol benzoate 73 15 Oxprenolol 115 12 Oestriol 147 13 Oxyalkyl-guanidines 112 12 Oestriol dihemisuccinate 15 N·Oxydationen 169 (Styptanon®) 147 14 1, 2ot-Oxydo-4, 6-androstadien• 12 Oestrogen 53, 55, 73, 79, 87, 88 -3,17-dione (OADD) 185 12 Oestrogen deficiency 147 14 1, 2ot-Oxydoandrostan- 3, 17 -dione 12 Oestrogenic activity 146 (OAD) 184 12 Oestrogenic stimulation 109 13 Oxylidine (3-Benzoyloxyquinucli• 12 Oestrogens 79, 111, 113, 146 dine) 313, 331 12 Oestrone 80 14 Oxymesterone 173, 177 15 Oleandomycin 215 13 Oxymetazoline (Nasivin) 118 12 Oleochrysin 229 14 Oxymetholone 162,176,178,179 14 l>lfilm 299 12 Oxyphenbutazon(e) (Tanderil) 22, 241 13 Olivacine 33 14 -72 12 Oogenesis 52 15 - 149, 158, 195, 218 13 Ophiobolin 40 14 Oxytetrazyklin 364 13 Ophiobolin A 40 12 Oxytocin 16, 333 13 Ophiobolin B 40 13 Ophiobolosin A 40 12 PABA (p-Aminobenoic acid) 304, 391, 13 Ophthalmology 330 393 12 Opipramol (Insidon) 207 14 - 39 13 OPSPA (N-[3-0xapentamenthyle· 15 - 281, 293, 307 ne]-N', NH-diethylenethiophos- 12 Pacatal 200 phoramide) 144 12 Pacemaker 304, 326 14 Optical rotary dispersion 70 14 PAeG (Polyiithylenglykole) 343,363 12 Oradexon 253 15 Paittie diseases 60 372 Index Vol. 12-15

15 Paittic drug 18 14 Pethidine 225 12 Palaprin 238 13 PGEl (Prostaglandin E l ) 230 15 Paludrine 43 12 Pharmaceutical market 38 14 PAM (Pralidoxim) 86, 302 15 Pharmaka, Stoffwechsel 187 13 PAM-1392 [2,4-Diamino-6-(3,4- 15 Pharmakogenetik 183 -dichlorobenzylamino) quinazolineJ 205 15 Pharmakokinetik 151 13 PAM-1481 (4'-[N-(3,5-Dichloro• 15 Phenacetin 156, 173 salicylidene) sulfanilylJ acetanilide) 203 15 Phenacetin, Stoffwechsel 175 12 Pamaquine 303 12 Phenaglycodol (Acalo, Sinforil, 15 - 166 Ultran) 197 14 Panaxynol 517,525 14 o-Phenanthroline 90 13 Pancreas, hormones of 363 14 Phenanthroline 200 12 Pantothenic acid 13 12 1,10-Phenantroline 331 15 - 212 15 Phenarsin 164 12 Papaverine 295, 316 12 Phenazon (Antipyrin, Analgesine) 240 14 - 40 14 - 359 13 PAPS (3'-Phosphoadenosine-5'• 15 Phencyclidine 86 -phosphosulfate) 148 12 Phenelzine (Nardil, Stinerval) 12 Paraaminobenzoic acid (PABA) 24, 116, 208 304, 391, 393 12 Phenergan 310 14 - 39 14 Phenethiazillin 296 15 - 281, 293, 307 12 Phenethicillin 371 14 Paraaminosalicylic acid (PAS) 46 13 IX-Phenethylguanidine 111 14 Paracetamol 330, 371 15 2-Phenethy1cyclopropylamine 234 12 Paraflex 198 12 Phenformin (DBI) 16, 157 14 Paramethasone 176 13 - 279 12 Paramomycin 20 12 Pheniprazine (Catron) 316 14 Paramyzin 355 12 Phenobarbital 22 12 Parasitic diseases 410,414 13 141 12 Parasympatholytic action 305 14 - 27 14 Parathion 31 15 - 15~ 155, 15~ 191 15 - 175 14 Phenobarbitone 233 13 Parathyroid hormone 349, 364 14 Phenolrot 358 12 Pargyline (Eutonyl) 28 12 Phenopyrazon (Diphenox) 241 13 - 109 14 Phenothiazine 114, 325 12 Parkemed 262 12 Phenoxybenzamine 324 12 Parnate 208 l3 2-Phenoxybutyric acid derivatives 252 14 Partikelgrosse 318, 321, 330 15 2-Phenoxycyclopropylamine 234,241 14 PAS (p-Aminosalizylsaure, 13 Phenoxyethylamines 120 paraaminosalicylicacid) 46, 305 13 p-Phenoxyphenyl methane- 14 Pastinaca-Aldehyd 526 -sulfonate 257 12 Pasturella tularensis 18 12 Phenprobamat (Gamaquil, Istonil, 14 Patentblau AE 364 Proformiphen) 190, 197 12 Pelvispondylitis ossificans 172, 271, 274 13 Phentolamine (Regitine) 118 14 Pemolin 369 13 Phenylacetic acid derivatives 247 13 Pempidine 110 15 Phenylarsonsaure (Atoxyl) 160, 163 12 Penbritin 378 14 1-(2'-Phenylathyl)-4-propin-(2)• 14 Penicillamine 21 -yl-4-propionyloxypiperidin 458 12 Penicillin 18, 33 12 Phenylbutazon(e) (Diphenylbutazon, 14 - 102 Butazolidin, Elmedal) 22, 31, 241 15 - 39,43,44 14 - 18, 24, 25, 31, 72, 76, 298 15 Penicillin G (Benzylpenicillin) 214 15 - 150, 158, 218 12 Penizillin 215, 216 13 Phenylbutazone, metabolism of 164 14 Penizillin G 368, 369 14 1-Phenyl-butin(3)-ol-(I) 391 14 Penizillin G- Prokain 281 13 2- Phenylbutyric acid 247 12 Pentamethonium 28 15 cis-2-Pheny1cyclopropanecarboxylic 13 Pentaquine 124 acid 264 14 Pentetrazol 234 15 2- Pheny1cyclopropanecarboxylic 14 Pentin-(4)-saure 480 acid derivatives 231 14 Pentobarbital 355 15 dl-trans-2-Pheny1cyclopropylamine 243 13 Peptic ulcers 325 15 2-Phenylcyclopropylamine 243 13 Perezone 45 15 2-Pheny1cyclopropylamines, 12 Pergonal 64 condensed-ring 237 13 Peridontal infections 38 14 3-Phenyl-3,4-dihydroquinazoline 228 14 Peristaltik 290 14 1-Phenyl-2,3-dimethyl-4-(2- 13 Perivine 33 -methylquinazol-4-one-3-yl)- 12 Perparin 347 -isopyrazol-5-one 239 12 Pertofran 207 12 Phenylephrine 319, 339 12 Pertranquil 190 14 - 43 13 Pesticides 39 14 7-Phenyl-heptaen-(2)-diin- 14 Pestizide 275 -(4,6)-saure 481 Index Vol. 12-15 373

14 1-Phenyl-hexadiin-(1,3)-ol-(5) 484 13 Plastoquinones A 67 15 Phenylhydroxybutylphenazon 158 13 Plastoquinones C 67 14 5-Phenyl-penten-(2)-in-{4)-ol-(1) 484 12 Plegizil 200 14 5-Phenylpentin-(4)-saure 480 14 Plysorbat 80 351 13 Phenylpiperazines 121 12 PMSG (Pregnant mare serulll 14 1-Phenylpropin-(2)-ols-(1), Carbamat 392 gonadotrophin) 54 14 Phenylpropiolsaure 477 12 Pneumococcal pneumonia 18 14 3-Phenyl-4-quinazolone 225 12 Pneumonia 19, 371, 392, 393, 419 15 Nl-Phenylsulfanilamides 139, 291, 307 12 Podophyllinsaurehydrazid (Proresid) 12 Phenyramidol 22 218 14 Phenytoin 333 12 Podophyllotoxin 106 14 Phenytoin-Natrium 370 14 Polar groups 72 13 Phorbol 18 12 Poliomvelitis 17 13 Phospharcol 319 12 Polyarthritis 217,223 14 Phosphatidic acid 89 14 - 171 13 3'-Phosphoadenosine-5'-phospho- 12 Polyarthritis chronic a 172, 234, 270, 273 sulfate 148 14 Polyathylenglykol (PAcG) 343, 363 14 Phospholipids 109 13 Polydesmus vicinus L. 44 14 Phospholipoproteins 109 14 Polyferose® 358 14 Phosphoprotein 95 14 Polygalacturonic acid 88 14 Phosphorus metabolism 151 14 Polyglucoses 104 12 Phosphorylation, oxydative 305 14 Polyine 517 14 Phosvitin (PV) 90 14 Polymere 342 14 Phthalimide, N-(4-Aminobutin- 14 Polymorphie 310 -(2)-yl)-substituierte 436 14 Polymorphismus 310 12 Phthalimide derivatives 297,298, 308 12 Polymyxin 386 13 Physalaemin 127 14 Polymyxin-B 103 13 Physalaemus fuscumaculatus 127 15 - 215 12 Physiotherapie 210, 279 12 Polymyxin E 377 14 Physostigmine 112 12 Polymyxins 377, 383 13 Phytophthora infestans 16 12 Polypeptides 333 13 Picrotin 15 13 - 127 13 Picrotoxin 54 14 Polyphloretin phosphate 104 13 Picrotoxinin 15 13 Pol yporenic acid A 30 13 (+ )-O(-Pinene 44 13 Polyporenic acid C 30 14 Piperazinsalze 301 14 Polysaccharides 85, 87 13 Piperidinobutyrophenones 120 14 Polysorbat 20 349, 351 15 Piper methysticum Forst 73 15 Poly thiazide 219 13 Piperoxan 114 14 Polyvinylpyrrolidon (PVP) 343, 362 13 0(-Pipitzol 45 12 Ponstan 262 13 P-Pipitzol 45 12 Population explosion 49, 50 15 Piptodenia peregrina 73 12 Population limitation 49 15 Pitta 59 12 Potassium therapy 335 13 Plant hormone 246 15 Potency index 140 12 Planovin® 151 15 Potentiometric titration 345 12 Plaquenil 232 14 Practolol 38 12 Plasil (MetocJopramidc) 346 15 - 116 13 Plasma 223 15 Prakriti 18 15 Plasmabindung 184 14 Pralidoxim (PAM, 2-PAM) 23,302 14 Plasma concentration 13 12 Pramidon 240 13 Plasma half-life 157 15 Pramana 17 13 Plasma histamine 352 15 Prayojana 15 13 Plasma kinins 356 15 Prazepalll 265 14 Plasma levels 25 12 Prazine 199 13 Plasma lipids 223 12 Prednifor 252 13 Plasma proteins 152 12 Prednisolon (Dacortin, Decortin H, 14 - 40 DeJta-Cortef, Delta-Cortril, Di-Adreson 13 Plasma volume 152 F, Hostacortin H, Meticortelone, Sche• 13 Plasmin 357 risolone, Ultracorten H) 252, 333 13 Plasminogen 357 14 - 164,171,173,174,175,177,180,184 13 Plasminogen activation 357 15 - 149,150,213 15 Plasmochin 167 13 Prednisolone, 21-Bornan-10-oate esters 13 Plasmodium berghei 174, 184 of 62 14 - 485 14 Prednisolone hemisuccinate 174 13 Plasmodium cathemerium 175 12 Prednison (Cortancyl, De1cortin, Delta• 13 Plasmodium cynomolgi 207 cortene, Delta-Cortisone, Deltasone, 12 Plasmodium falciparum 421 Hostacortin, Meticorten, Prednifor, 13 - 198 Ultracorten) 141, 252 14 Plasmodium gaUinaceum 220 14 - 143, 149, 172, 175, 178, 179, 180, 182, 13 Plasmodium knowlesi 207 183, 364 13 Plasmodium vivax 198 15 - 213 374 Index Vol. 12-15

12 Pregnant mare serum gonadotrophin 14 2-(n-Propyl)-3-(P-chloro-o-tolyl)-4-quina• (PMSG) 54 zolone 234 14 3-Pregnene-3f3-o1-7-one 184 15 6-propylthiopurin 150 13 Prehelminthosporal 14 12 Proresid (Podophyllinsaurehydrazid, 13 Prehelminthosporol 14 SPoIl 218, 219 12 Premarin® 147 13 Prostaglandin A2 (Medullin) 125 12 Prenderol (Diathylpropandiol) 197 13 Prostaglandin El 125, 230 12 Prenylamin(e) (Segontin, Corontin) 317 13 Pros taglandin E2 125 15 - 163 13 Prosympal 114 12 Price con trois 42 14 Protamine 22, 79, 112 12 Primaquine 20, 303 12 Protein binding 430, 431, 434 13 - 178 14 Protein catabolism 150 13 Priscol(ine) (Tolazoline) 118 14 Protein metabolism 140 13 Pristimerin 30, 34 14 Proteolipid 82 13 Privine (Naphazoline) 118 12 Proteus 372, 380, 386 12 Probenecid (Benemid) 286 12 Provera® (MAP, Medroxy-progesterone• 14 - 24 acetate) 78, 151 12 Procaine 295, 303 12 Proviron® 146 14 - 108, 109, 111 13 Pruritus 352 12 Procaine amide 27,304, 340, 346 13 PSBA (4', 4"'-[p-Phenylenebis-(methy• 15 Procarbazin 165 lidyneimino-p-phenylene-sulfonyl)]• 13 Profibrinolysin 357 bisacetanilide) 199 12 Proformiphen 197 13 pSBF (4', 4"'-[p-Phenylenebis-(methy• 12 Progesterone 73, 76, 78, 110, 147, 148 lidyneimino-p-phenylene-sulfonyl) ] 14 - 121, 126 bisformanilide 198, 201 15 -213 12 Ps. aeruginosa 382, 386 12 Progesterone acetate (Provera®) 152 15 Pseudohallucinations 93 12 Progesterone derivatives 78 12 Pseudomonas 372, 386 12 Progesterone therapy 149 14 Pseudopolymorphie 314 12 Progestins 76, 98, 148 15 Psilocin 75 12 Progestin therapy 90 15 Psilocybe mexicana Heim 72 15 Proguanil 167 15 Psilocybin 75 14 Promazine 119 15 Psychedelic psychotherapy 97 14 Promaziniumchlorid 365 14 Psychoactive drugs 119 12 Promethazine 312 15 Psycholytic psychotherapy 96 14 - 95,117 14 psychopharmaca 47 12 Promoxolane 197 14 Psychopharmacological agents 113 12 Pronethalol (Alderiine, Nethalide) 321, 12 Psychopharmaka 187, 189 322 15 - 186 13 - 119 12 Psychopharmaka, antidepressive 205 15 - 108 12 Psychopharmakotherapie 187 12 Prontosil 17 15 Psychophysiologic effects 84 13 - 146 12 Psychosomatik 185 14 Prontosil rubrum 31 12 Psychotherapeutic agents 23 15 -164 12 psychotherapie 187 14 Propanidid 353 15 Psychotherapy 80 14 Propargylalkohol 390 15 Psychotomimetic agents 95, 70 14 Propin 389 15 Psychotomimetic agents, complications 14 Propin-(2)-ole-(I), sekundare 405 of 97 14 Propin-(2)-yl-amin 453 14 psychotrope Wirkungen 400 14 Propin-(2)-ylamine, terWire 454 12 Pteridine 26 14 4-Propin-(2)-ylantipyrin 459 15 Pteroylglutamic acid 212 14 Propin-(2)-ylather 440 12 Puerperal fever 18 14 Propin-(2)-ylbromid 479 12 Pulmonary embolism 95 14 Propin-(2)-yl-carbinole, tertiare 409 14 Pulveroblaten 292 14 1-Propin-(2)-yl-cyclohexylcarbama te 15 Purinderivate 194 397,412 15 Purine 217 14 o-Propin-(2)-yloxy-benzamid 401 14 PV (Phosvitin) 90 14 1-Propin-(2)-yloxy-1,1-diphenylessig- 14 PVP (Polyvinylpyrrolidon) 343, 362 saure, Ester 460 15 Pyelitis 49 14 4-Propin-(2)-ylpiperidinole-(4), Ester 12 Pyeloniphritis 385 461 15 Pyrantel 143 14 N-Propin-(2)-yl-sulfuryldiamide 401, 14 Pyrathiazine 94 421 13 Pyrethrins 60 14 Propiolsaure 528 15 - 264 12 d-Propoxyphene 22 12 Pyribenzamine 310 12 Propranolol (Inderal) 27, 321, 322, 338, 14 Pyributamine 94 346,348 13 3-Pyridineacetic acid 226 13 - 119,230 13 Pyridinolcarbamante 276 14 - 38, 91, 99 13 Pyridostigmine 313 15 - 108 12 Pyridoxine 13 Index Vol. 12-15 375

15 Pyridoxine 212 13 Rauwolfia serpentina 19 13 3-Pyridylcarbinol 227 13 Rauwolscine 50 14 2-({3-Pyridyl-(2")-ethenyl)-3-(o-tolyl)-4- 14 Receptor substances 61, 79 quinazolone 232 12 Recetan 349 13 5-(3-Pyridyl)-tetrazole 228 12 Redul® 157 12 Pyrimethamine 20, 421 13 Regitine (Phentolamine) 118 13 - 178,188 14 Reizwirkungen 299 13 Pyrimethamine derivatives 188 12 Relaxar 196 13 Pyrimethamine salts 189 13 Renal excretion 139 13 Pyrimidine nucleoside 165 14 - 16 13 Pyrimidine nucleoside deaminase 164 13 Renal function 153 13 Pyrimidines 123 12 Research 44 15 Primidon 156 15 - 208 13 Pyrophos 319 12 Reserpine (Sedaraupin, Serpasil) 28, 13 Pyrr hoeoris apterus L. 47 82,202, 313 13 Pyrrolizidine 294 13 - 28, 34, 50, 54, 55, 60 13 Pyrthrins 39 14 - 92, 119, 367 15 - 217 12 Quaddeltherapie 269 14 Resistan t strains 49 14 Quadrifidine Al 521 12 Resochin 232 13 Qualidile 328, 331 14 Retard-Praparate 285 13 Quarzanbromide 318 15 Retikulummembranen 152 13 Quassin 15 13 Retinochrome 66 12 Quiloflex 198 13 Rhazia stricta 19 12 Quinacrine 303 13 Rhemannic acid (Lantadene A) 65 13 - 178 12 Rheuma 167 13 Quinamine 20 12 Rheumaanfalligkeit 179 12 Rheumabegriff 172 13 Quinazolines 123 14 Quinazolone 219 12 Rheumabehandlung 184 14 4-Quinazolone deriva tes 222 12 Rheumadiagnostik 177 13 Quinazosin 124 12 Rheumaerkrankungen 173,174 14 Quinethazone (Aquamox®, Hydromox®) 12 Rheumaerkrankungen, Bewertung 175 220, 245, 246 12 Rheumafaktor 178 13 Quinicine 20 12 Rheumainvaliditat 180 12 Quinidine 27, 294 12 Rheumamorbiditat 179, 181 14 - 101 12 Rheumapassivum 180 12 Quinidine, tritium-labelled 301 12 Rheuma-Pathogenese 175 12 Quinine 300 12 Rheumaprophylaxe 277 13 - 19, 48, 50, 51 12 Rheumatherapie 181 14 - 18, 113 12 Rheumatherapie, Methoden 181 15 - 43 12 Rheumatismus 169, 170 13 Quinine pamoate 211 12 Rheumatologie 167 13 Quinolines 123 12 Rheumatologische Indikationen 194 13 {3-(Quinuclidil-2)-propionic acid 306 14 Rhinencephalon 97 13 Quinuclidine 294, 296 14 Rhinitis 182 13 Quinuclidine-3-acetic acid 303 14 Rhinosinusitis 182 13 Quinuclidine amino acids 302 13 Rhodopsin 66 13 Quinuclidine, bisquaternary derivatives 12 Rhythmol (Ro-2-5803) 330 of 325 12 Riboflavin 13 13 Quinuclidinecarbinols 302 15 Ribonuclease 216 13 Quinuclidine-2-carboxylic acid 298 300 14 Ribonucleoprotein 82 13 quinuclidine carboxylic acids, deri~a- 15 Ribosomes 312 tlves of 322 14 Ricinus communis L. 517 13 Quinuclidine derivatives 326, 327 13 Ring hydroxylation 144 13 Quinuclidine, synthesis of 298 13 Rishitin 16 13 Quinuclidon-2 299 15 Rivea eorymbosa 74 13 Quinuc1idone-3 296, 299, 303, 304, 305 14 RNA (Ribonucleic acid) 88, 102 12 QX-572(N, N-Bis phenylcarbamoyl- 12 Ro-2-5803 (Rhythmol) 330 methyl-dimethylammonium Hel) 308 15 Ro 3-3528 (6,7-Dimethyl-cx-[(isopro• pylamino)methyl]-2-benzofuranmetha• noll 114 12 Radiocobalt irradiation 105 13 Ro 4-4602 (Seryl-2,3,4-trihydroxy- 14 Radiotherapy 181 benzylhydrazine) 105 13 Ramycin 29 12 Robaxin 196 12 Rastinon® 157 13 Romalea mieroptera 44 14 Rattus norvegieus 210 12 Rontgentherapie 214 14 Rattus rattus 212 13 Roridin A 34 13 Rauvomitine 50 13 12,278 R.P. (4,4'-[1,4-Piperazinediylbis• 12 Rauwolfia 26 (l-methylethylene-imino) ]bis [7 -chloro• 12 Rauwolfia alcaloids 312 quinoline]) 177 12 Rauwolfia serpent ina 23 13 Rubia tinetorum 16 376 Index Vol. 12-15

12 Rumalon 263, 264, 265 14 Shock 197 13 Ryanodine 40, 64 14 Shock, resistance to 210 14 Shock, treatment of 214 13 Sialic acid (N-Acetylneuramillic acid) 345 12 Sabin vaccine 17 13 Siccanin 17, 40 12 Saimiri sciureus 55 13 Side-chain oxidation 143 14 Salben 324, 356 12 Silubin'" 158 13 Salicylic acid 230 12 Simes CO 405 (Hydrobutamine) 349 14 - 18,71 i2 Sinaxar 198 15 Salicylsaure 156 12 Sinforil 197 12 Salizin 234 12 Sinus rhythm 343 12 Salizylatintoxikation 237 12 Siquil (Triflupromazin) 200 12 Salizylattherapie 234 14 Sirupe 286 12 Salizylismus 287 12 Skelaxin 196 12 Salizylsaure 234, 238, 286 13 SKF 525-A (p-Diethylaminoethyl- 14 - 352, 361 diphenylpropyl acetate) 141, 266 12 Salk vaccine 17 12 Skin 30, 372 12 Salmonella 371, 380, 384 13 Skin infections 29 12 Salmonelloses 380 15 Slaframin (I-Acetoxy-8-aminoocta- 14 Salzform 299 hydroindolizin) 168 15 Sammohini 34 14 Small molecule 66, 67 12 Sanochrysin 229 13 SN-6,771 (Bialamicol) 176 12 Sanoma 197 13 SN-1O,275 (6,8-Dichloro-2-phenyl- 15 Sanskrit 25 oc-2-piperidyl-4-quinolinemethanol) 175 13 Saponin 64 12 Sodium bicarbonate 336 15 SAR (Structure-activity relationships) 14 - 17 124 12 Sodium lactate 336, 343 12 Saroten 208 12 Soleorubin (Aurubin) 229 12 SC 7031 (Disopryramide) 350 12 Solganal 229 12 Scherisolone 252 12 Solganal B oleosum 230 12 Scheroson 252 14 Solubilisatoren 349 12 Scheroson F 252 14 Solubility 69 13 Schistocerca gregaria Forsk 15 12 Soma 197 12 Schlafanstossender Effekt 193 12 Somalgit 197 15 Schwefelkohlenstoff 177 12 Somipront 262 13 SDDS (3-Sulfamoyl-4,4'-sulfonyl- 13 Sorbitol hexanicotinate 227 dianiline) 195 12 Sotalol (MJ 1999) 322 15 Secretin 216 13 - 119 15 Secobarbital 189 14 - 38 12 Sedaraupin 202 15 - 111 13 Sedative activity 55 14 SPAI (Steroid protein activity index) 149 13 Sedative agent 28 14 Span'" 278 12 Sedatives 311 14 Spasmogens 40,43 14 Sedative Wirkung 400,404 14 Spasmolytica 438 14 Sedativum 236, 394, 395 13 Spasmolytic agent 318 13 Seedlac 45 12 Spasmolytic drugs 316 12 Segontin 317 13 Spasmolytin 318 14 Sekobarbital-Natrium 351 14 Spasmolytische Wirkung 390, 392, 404, 12 Selvigon 331 438 12 Selyesche Theorie 171 15 Spectinomycin 284, 289, 298, 311 13 Sempervirine 50 14 Spermine 88, 93 13 Senecio alkaloids 26 12 Sperm transport 103 12 Sensival 208 12 SP-G (Podophyllotoxin-p-n-benzyliden- 12 Septicaemia 372, 385 glukosid) 219 12 Sequens'" 151 12 SP-I (Proresid) 219 14 Serotonin (5-HT) 96 12 Spondylosis deformans 177 15 - 75 13 Squalene 259 13 Serotonin antagonist 38 14 SSM (Standard safety margin) 227 14 - 96 12 ST-7090 (Hexobendin, Ustimon) 330 12 Serpasil 202 14 Stabilisatoren 334 13 Serpentine 50, 58 13 Stanazolol 274 13 Serum 223 14 Standard safety margin (SSM) 227 14 Serum albumin 101 14 Stanozolol 143, 149, 151, 169, 182 14 Serum proteins 70, 74, 77, 90 13 Staphylococcal infections 29 13 Seryl-2, 3, 4,-trihydroxybenzylhydrazine 12 Staphylococcal penicillinase 381 (Ro 4-4602) 105 12 Staphylococcus aureus 18 13 Sesquiterpenoids 12 13 - 33 15 Shariraka 15 12 Staphylococcus Wachsmuth 427 12 Sheehan's disease 67 13 Starch 349 12 Shigella flexneri 419 12 Stein-Leventhal syndrome 66,69 12 Shigella sonnei 419 13 Stemmadenine 24 Index Vol. 12-15 377

14 Stenisone® 141,175 12 Sulfanilamid(c) 391, 433 15 Sterculic acid 263 14 - 352, 359 12 Sterilization 53 15 - 164 14 Steroid 36644-Ba 145 13 4' -Sulfanilylacetanilide 197 13 Steroid hormones 273 13 4'-Sulfanilylanilides 192 14 - 308 12 Sulfaphenazole 399, 407, 437, 449 15 - 212 12 Sulfaproxyline 407 14 Steroid protein activity index (SPAI) 149 12 Sulfapyridine 17,392,400,425 14 Steroids 120, 146 12 Sulfapyrimidine (Sulfadiazine) 17 12 Stevens-Johnson syndrome 441 12 Sulfathiazole 17, 400 15 Stickstoff-Lost 166 14 - 312, 313, 359, 368 14 Stilbamidine 86 15 - 300, 307 14 Stilbene derivates 78 15 Sulfathiazole sodium 292 12 Stilboestrol 53, 73 12 Sulfathiourea 400 12 Stilboestrol derivatives 74 12 Sulfinpyrazon(e) (Anturan) 241, 286 12 Stilboestrol, monobenzyl ether of 74, 75 15 - 158, 218 12 Stinerval 208 12 Sulfisomidine 405, 436 15 Stoffwechsel, physiologische Schwankun• 12 Sulfisomidine ring 438 gen 192 12 Sulfisoxazol(e) 17,18,405 13 Storage of drugs 139 14 - 332 15 STP (2,5-Dimethoxy-4-methylamphet- 15 - 291, 300, 307, 327, 333 amine) 77 14 2-Sulfobenzoesaureimide 436 12 Strahlenschutzmittel 258 12 Sulfonamid(e) 216 12 Streptococcus pyogenes 18 14 - 102 13 Streptomyces mobaraensis 18 15 Sulfonamide action, mechanisms of 307 12 Streptomycin 18, 33, 107, 375 15 Sulfonamide analogs 336 14 - 103, 385 12 Sulfonamide derivatives 400, 401, 402, 15 - 49,214 403,404 13 Strictosidine 21 13 - 204 12 Strophantine 327 12 Sulfonamide dosage 421, 422 12 K-Strophantine 313 12 Sulfonamides 409 13 Structural modification 59 15 - 281, 284, 290, 307 13 Structural specificity 49 12 Sulfonamides, action of 393 15 Structure-activity 139, 335 12 Sulfonamides, classification of 397 15 Structure-activity relationships (SAR) 12 Sulfonamides, excretion of 429 124 12 Sulfonamides, in vitro activity of 433, 14 Strychnin, Antagonist 396 434,439 13 Strychnine 48, 52 12 Sulfonamides, long-acting 426, 450 12 Stryptanon® 147 12 Suifonamides, short-acting 426, 450 12 S. typhi 379 13 3',3"'-Sulfonylbisacetanilide 194 12 Styramat (Linaxar, Sinaxar) 198 13 4',4"-Sulfonylbisacetanilide 193, 195 13 Styrax japonica 64 13 4',4"'-Sulfonylbisformanilide 193 13 Succinylcholine 146 13 3,3'-[Sulfonylbis(p-phenyleneimino- 14 - 77 methylene) J-di-2-thiazolidinethione 194 15 - 183 12 Sulformethoxine 408,419,432,438 12 Sulfacarbamide 405 13 Sulfur oxidation 144 12 Sulfacetamide 425 14 SUlfurtransferase 22 12 Sulfachlorpyridazine 408, 437 12 Sulphamethoxazole (Gantanol) 383 12 Sulfadiazine (Sulfapyrimidine) 17,400, 12 Sulphonamides 373, 383, 385 407, 425, 433, 439 14 Suppositorien 286, 324, 356 13 - 160 12 Suprametil 253 12 Sulfadicramide 400 13 Suramin-dihydrotriazine salts 183 12 Sulfadimethoxazole 430 12 Suramin sodium 390 12 Sulfadimethoxine 407, 433, 436, 439 15 Surgical instruments 36 12 Sulfadimethyloxazole 399, 407 12 Surmontil (Trimeprimin) 207 12 Sulfadimidine 400, 436 14 Suspensionssirupe 286 12 Sulfaethidole 400 15 Svabhavika 16 12 Sulfamerazine 400, 407, 425, 443 15 Swasthya 15 12 Sulfamethazine 407 13 Sweroside 21 12 Sulfamethizole 405 13 Swertia caroliniensis 21 12 Sulfamethomidine 408 13 Swertiamarin 21 12 Sulfamethoxazole 399, 407, 432, 433, 12 Sympathol (Synephrine) 318 449 15 - (Oxedrin) 161 12 Sulfamethoxydiazine 408, 438 13 Sympathomimetic agent 106 12 Sulfamethoxypyrazine 408, 437 12 Sympathomimetics 318 12 Sulfamethoxypyridazine 17,407,436 12 Synephrine (Sympathol) 318 12 Sulfamethoyl 400 15 Synergism 317, 321 12 Sulfamethyldiazine 407, 438 15 Synergistische Wirkungen 194 12 Sulfamoxol(e) 449 12 Synovektomie 233 14 - 311, 312 12 Syphilis 19 13 3-Sulfamoyl-4,4'-sulfonyldianiline 194 12 Syrosingopine 83 378 Index Vol. 12-15

15 Tabernanthe iboga 74 12 Thio-TEPA (Triethylene-thiophosphor- 14 Tabletten 285, 356 amide) 105 12 TACE (Trianisy1chloroethylene) 56,65, 13 - 144 72,74 12 Thiothixene 23 12 Tachycardias 342 12 Thiouracil 16 14 Tachyphylaxis 24,49 14 6-Thioxanthin-Derivate 440 12 Tanderil 241 15 TMA (3,4,5-Trimethoxyamphetamine) 14 Tannic acid 20 72,77 12 Tantum 263 15 TMA-2 (2,4,5-Trimethoxyamphetamine) 12 Taractan 201 77 13 TARIF (Transferable anaphylactoid 15 TMA-3 (2,3,4,-Trimethoxyamphetamine) reaction inducing factor) 357 77 14 Tartrazin 364 15 THP (Tetrahydropapaverolin) 159 13 Tauranin 17 12 Thromboembolic disease 94 14 TBG (Thyroid-binding globulin) 71 12 Thrombosis 95 14 Tebanyl® 305 13 fJ-Thujaplicin 34, 50, 63 13 Tecomine 50 13 y-Thujaplicin 63 13 Tecostanine 50 12 Thymerethika 204, 206 12 TEM (Tretamine, Triethylene-melamine) 15 Thymidine 333 53, 105, 112 12 Thymoleptika 204, 205, 209 14 Teniside 347, 349 13 o-Thymotinic acid, derivatives of 61 12 Tenotomien 271 13 Thymoxamine 60 13 Terpenoid Antibiotics 29 12 Thyroid 16 13 Terpenoid derivatives 13 13 - 160 13 Terpenoids, toxic 64 13 Thyroid activity 242 12 Testosterone 81, 142 14 Thyroid-binding globulin (TBG) 71 13 - 272 13 Thyroid gland 362 14 Testosterone-4-C" 144 12 Thyrotoxicosis 16 12 Testosterone derivatives 77 12 Thyroxine 14, 16 12 Testosterone propionate 85, 144, 145 13 - 241, 242, 244, 246 14 - 142, 143, 144, 152, 154, 163, 165, 12 n-Thyroxine 29 169, 172, 178, 180, 181 15 L-Thyroxin 190 15 Tetraathylthiuram (Disulfiram, 13 Thyroxine, synthesis of 242 Antabus®) 196 14 Tissue proteins 74 15 Tetraathylzinn 177 12 TM-10 (Xylocholin) 325 12 Tetracaine 308 13 - 113 14 - 110,113 12 Tocopherol 13 12 Tetracycline 18, 377, 385 15 et-Tocopherol 212 13 - 29 13 et-Tocopherolquinone 67 14 - 104, 183 12 Tofranil (Imipramin) 207 15 - 215, 281, 284, 285, 300, 326 12 Tolazamide 16 15 Tetracycline analogs 336 12 Tolazoline (Priscoline) 324 15 Tetrahydrocannabinols 82 13 - 118 15 LI"-Tetrahydrocannabinol 79 12 Tolbutamid(e) (Rastinon®, Orinase®) 15 LIS-Tetrahydrocannabinol (THC) 72, 78 16, 157 14 1,2, 3,4-Tetrahydro-chinazolindion- 14 - 25, 29, 290 (2,3), Derivate 466 15 - 155 14 1,2, 3,4-Tetrahydro-2,4-dioxo-quina- 14 Tolerance 49 zoline derivate 239 12 Toiseram 196 14 Tetrahydronororipavin 457 12 Toiseron 196 15 Tetrahydropapaverolin (THP) 159 12 Tomanol283 13 Tetrahydrozoline (Tyzine) 118 12 Tonoquil 200 14 Tetrakain 353 13 Toxaphene 39 14 Tetrazyklin 352,358, 368, 369 14 Toxizitat 301 14 Tetrazykliniumchlorid 289 13 Toxicity 154 12 Thalidomide 22, 48 13 Toxicodendron capense 15 15 THC, metabolite of 83 13 Toxiferine 38 15 THC (LIS-Tetrahydrocannabinol) 72, 82 12 Toxoplasmosis 421 13 Lll-THC (Lll-Tetrahydrocannabinol) 58 12 Trachoma 421 12 Theophylline 30 12 Trancopal 198 14 - 47, 306 12 Tranquilizer 190 12 Therapeutic index 446 13 - 331 12 Thiamin(e) 13 12 Tranquilizer, Nebenerscheinungen 195 15 - 212 14 Transcortin 162 14 3-Thiazolyl-4-quinazolones 249 12 Transferase activity 396 12 Thiochrysin 229 12 Trany1cypromin(e) (Eskapar, Parnate) 12 Thiocolciran 105 24, 208 12 Thioguanine 112 15 - 230 12 Thiopropazat 200 15 Tranylcypromine derivates 231 12 Thioridazine (Mellaril) 25, 200, 312 12 Trasentine 317 14 Thiosulfate 22 12 Trasicor (CIBA 39089-Ba) 349 Index Yol. 12-15 379

13 Trasicor (CIBA 39089-Ba) 119 14 Tryptophan 364 14 Traumatic shock 205, 206 12 Tuberculosis 19, 406 12 Traumatic stimulus 113 14 - 184 14 Tremor 428 14 Tuberculostatic activity 251 14 Tremorin [1,4-Dipyrrolidino-butin-(2)] 14 Tuberkulose 478 427 12 d-Tubocurarine 31 14 Tremorin, Antagonist 438 14 - 78, 80, 93, 100, 112 14 Tremorolytische Wirkung 429, 431, 434, 15 - 216 438 13 (+ )Tubocurarinc 328 12 Trenimon (Triaziquone, Trisathyleni• 15 Tumoren 173 minobenzochinon) 218, 219 13 Tutill 15 12 Trepidon 196 14 Tween 20® 352 12 Tretamine (TEM, Triethylenc-melamine) 14 Tween 80® 354 53, 112 13 Tybamate 141 12 Triamcinolon(e) (Kenacort, Kenacort A, 14 Tyloxapol 356 Ledercort, Ledercort A) 253 12 Typhoid fever 379, 406 14 - 149, 151, 178 14 - 183 12 Triamterene 26 14 Tyramin(e) 24 12 Trianisylchloroethylene (,fACE) 56,65 15 - 161 13 Triarylethanol derivatives 237 13 Tyzine (Tetrahydrozolille) 118 13 Triazines 122 12 Triaziquone (Trenimon) 219 12 U-11100A (Nafoxidine) 56, 72 12 Tribrom 228 14 Ulcus pepticum 439 12 Tribromauro 228 14 Cltracentrifugation 66 14 Trichlorathanol 328 12 Ultracorten 252 14 1,2,4-Trichlor-5-(3-jodpropin-(2)-yloxy)- 12 C1tracorten H 252 benzol 485 14 Cltrafiltration 66 13 Trichodermin 17 12 Ultran 197 13 Trichothecin 17, 40 13 Ul\lL 491 (Methysergide) 38 14 Tridecadien-(I, 11)-tetrain-(3,5, 7,9) 479 14 Ulldecin-(lO)-saure 480, 520 14 Tridecen-(I)-pentain-(3,5,7,9,11) 479 14 Undecin-(9)-saurehydrazid 452 15 Tridosha 17,19 13 Upjohn-22,105 (p-Phenoxyphenyl 14 TRIEG (Triethiodide of gallamine) methane-sulfonate) 257 85,86 15 Uracil 332 12 Triethylenemelamine (Tretamine) 53, 13 llracil arabinoside 164 112 12 Urbason 253 13 N, N', N"-Tricthylenethiophosphor• 14 Uricosuric action, reduction of 24 amide 144 15 Uridine 295 12 Trifluorperazine 25 12 Urikosurika 286 14 - 117 14 Urinary excretion 18 12 Triflupromazin (Siquil) 200 13 Urticaria 352 15 - 220 14 - 182, 214 14 Triin-en-carbonsaure 521 12 Us timon (ST-7090, Hexobendin) 330 12 Triiodothyronine 71, 158 14 lTV absorption spectra 65 13 L-3, 5, 3'-Triiodothyronine 243 15 Tri-o-kresylphosphat 176 15 Vaccenic acid 260 12 Trimeprimin (Surmontil) 207 12 Vagolytic agents 339 12 Trimepropimine 316 12 Valium 191 12 Trimethadione 22 14 Van der Waals forces 73, 338 13 Trimethidinium 37 15 Vall der \Vaals interactions 133, 134 12 Trimethoprim 382, 383, 385 14 Vasicine 252 15 Trimethoprin 333 13 Vasicinolle 252 15 2,3,4-Trimethoxyamphetamine (TMA-3) 12 Vasopressin 16 77 15 Vata 55 15 2,4,5-Trimethoxyamphetamine (T:\IA-2) 13 Vatensol (Guanoc1or) 115 77 15 Vatic diseases 57 15 3,4,5-Trimethoxyamphetamine (TMA) 15 Vayu 55 72,77 14 Veramon® 47 12 Triparanol (MER-2(l) 15, 48, 69 12 Verapamil (Isoptin, D 365) 348 13 - 235, 236, 240, 26Q, :2{)5 14 Vera truIll alkaloids 111 12 Triphenylethylene derivatives 56 12 Veratrum viride 28 12 Trisathyleniminobenzochinon 13 Verbenalin 20 (Trenimon) 218 13 (+)-cis-VerbenoI41 12 Trisulfonamides 406 13 Verrucarin A 32, 34 13 Triton 250 13 Verrucarin 13 34 14 TropfenlOsungen 286 13 Verrucarol 17 12 Truxal 201 15 Vihara l(j 12 Trypan 17 12 Vinblastine 17 14 Trypsin 289, 368 13 - 31, 32, 60 13 Tryptamine 24 15 - 217 12 Tryptizol 208 13 Vincaleukoblastine (Vinblastine) 24, 31 380 Index Vol. 12-15

13 Vincamine 57 13 Wortmannin 27 13 Vinca minoT L. 57 14 Wound healing 172,173 13 Vinca Tosea 32 12 Wounds 372 12 Vincristine 17 13 WR-17, 206 (IX,IX, IX, oe, IX', IX'-Hexa-chloro- 13 - 31,32 p-xylene) 176 15 - 217 14 Wyeron 518, 526 13 Vindoline 19,33 13 Vinleurosine 32 14 Xenon 106 13 Vinrosidine 32 12 X-Irradiation 52. 104 13 3-Vinylquinuclidine 304 12 X-Ray contrast agents 31 13 Virosine 33 12 Xylocholin (TM-10) 325 12 Viruses 442 13 - 113 14 Viscosity 70 13 Xylometazoline (Otrivin) 118 12 Vitamin A 13 14 - 292 13 Yeast 349 15 Vitamin B 43 14 - 214 14 Vitamin Bn 358 13 Yeast mannan 349, 359 15 - 212 13 Yohimbine 50,56 13 Vitamin Bl3 260 14 Vitamin C 357 14 Zein 94 12 Vitamin D2 (Calciferol) 13 12 Zellpermeabilitiit 259 13 - 349 14 Zeoli the 345 13 Vitamin D. 349 14 Zephaloridin 320 12 Vitamin K 13 13 Zerumbone 50 13 Vitamin Kl 67 13 Zizanin B 40 14 Vitamin K2 39 13 Zolertine (MA-1277) 122 14 Vitamin K. 362 12 Zoxamill 198 15 Vitamins 211 12 Zoxazolamid (Deflexol, Flexin, 12 Volidan® 151 Zoxamin, Zoxazolamin) 198 12 Volplan® 151 12 Zoxazolamin(e) (Deflexol, Flexin, Zoxamin, Zoxazolamid) 198 13 W-2531 [5-(4-Biphenylyl)-3-methyl- 13 - 163 valerie acid] 251 14 - 31 14 Warfarin 74, 75 15 - 160 13 Win. 5494 (Myordil) 235 14 Zykloguanil 302 13 Win-14,833 (Stanazolol) 274 12 Zyloric 287 14 Wirkstoffabgabe 292 14 Zyklothiazid 331 15 Wirkstoffkombinationen 186 13 Zymosan 359 14 Wirkstoff, Stabilitat 292 15 Zytochrom Puo 152,170 14 Wismut 359 12 Zytostatika 218, 233 13 Withaferin 27 15 - 165 Index Vol. 1-15 381

Index Vol. 1-15 SUBJECT INDEX SACHVERZEICHNIS TABLE DES MATIERES Vol. 1-15 (1959-1971)

Acetylen-Verbindungen als Arzneistoffe, Antiinflammatory drugs, biochemical natlirliche und synthetische and pharmacological properties 14, 387 (1970) 8, 321 (1965) p-Adrenergic blocking agents, pharma• Antikoagulantien, orale cology and structure-activity II, 226 (1968) 10, 46 (1966) Antimetabolites, revolution in p-Adrenergic blocking drugs, pharmacology pharmacology 2, 613 (1960) 15, 103 (1971) Arzneimittel, neue Allergy, pharmacological approach I, 531 (1959),2,251 (1960),3, 369 3, 409 (1961) (1961), 6, 347 (1963), 10, 360 (1966) Amidinstruktur in der Arzneistoff• Arzneimittel, Wert und Bewertung forschung 10, 90 (1966) II, 356 (1968) Arzneimittelwirkung, Einfluss der Amino- und Nitroderivate (aromatische), Formgebung biologische Oxydation und Reduktion 10, 204 (1966) 8, 195 (1965) Arzneimittelwirkung, galenische Aminonucleosid- Nephrose Formgebung 7, 341 (1964) 14,269 (1970) Amoebiasis, chemotherapy Atherosclerosis, cholesterol 8,11 (1965) and its relation to Anabolic steroids I, 127 (1959) 2,71 (1960) A yurvedic medicine Analgesia and addiction 15, 11 (1971) 5, 155 (1963) Androgenic-anabolic steroids and Basic research, in the US glucocorticoids, interactions pharmaceutical industry 14, 139 (1970) 15, 204 (1971) Anthelminticaforschung, neuere Biological activity, stereochemical Aspekte factors I, 243 (1959) 1,455 (1959) Anthelmintics, structure-activity 3,75 (1961) Antiarrhythmic compounds Cancer chemotherapy 12, 292 (1968) 8, 431 (1965) Antibiotics, structure and biogenesis Carcinogens, molecular geometry and 2, 591 (1960) mechanism of action Antibiotika, krebswirksame 4, 407 (1962) 3, 451 (1961) Central nervous system drugs, Antifertility substances, development biochemical effects 7, 133 (1964) 8,53 (1965) Antihypertensive agents Cholesterol, relation to atherosclerosis 4, 295 (1962), 13, 101 (1969) I, 127 (1959) Antiinflammatory agents, nonsteroid Cyclopropane compounds 10, 139 (1966) 15,227 (1971) 382 Index Vol. 1-15

3,4-Dihydroxypheny lalanine and 5-Hydroxytryptamine and related related compounds indolealkylamines 9, 223 (1966) 3, 151 (1961) Diuretics Hypolipidemic agents 2,9(1960) 13,217 (1969) Drug action and assay by microbial kinetics Indole compounds 15,271 (1971) 6, 75 (1963) Drug action, basic mechanisms Indolstruktur, in Medizin und Biologie 7,11 (1964) 2, 227 (1960) Drug combination, reduction of drug Ionenaustauscher, Anwendung in action Pharmazie und Medizin 14, 11 (1970) 1, 11 (1959) Drug latentiation Isotope, Anwendung in der pharma• 4, 221 (1962) zeutischen Forschung Drug-macromolecular interactions, 7,59 (1964) implications for pharmacological activity 14, 59 (1970) Lokalanasthetika, Konstitution und Drug metabolism Wirksamkeit 13, 136 (1969) 4, 353 (1962) Drug potency 15, 123 (1971) Malaria chemotherapy, repository Drug research antimalarial drugs 10, 11 (1966) 13,170 (1969) Drugs, biliary excretion and Medicinal chemistry, contribution to enterohepatic circulation medicine 9, 299 (1966) 12, 11 (1968) Mescaline, and related compounds Egg-white, reactivity of rat and man 11,11(1968) 13, 340 (1969) Metabolism of drugs, enzymatic Endocrinology, twenty years of research mechanisms 12, 137 (1968) 6,11 (1963) Enterobacterial infections, Metronidazol-Therapie, Trichomonasis chemotherapy of 9, 361 (1966) 12, 370 (1968) Molecular pharmacology, basis for drug design Filariasis, chemotherapy 10, 429 (1966) 9, 191 (1966) Monoaminoxydase-Hemmer Fluor, derives organiques d'interet 2,417 (1960) pharmacologique 3,9(1961) Narcotic antagonists Galenische Formgebung, Arzneimittel• 8, 261 (1965) wirkung 10,204 (1966), 14, 269 (1970) Phenothiazine und Azaphenothiazine Ganglienblocker 5, 269 (1963) 2, 297 (1960) Photochemistry of drugs 11,48 (1968) Heilmittel, Entwicklung Placebopro blem 10, 33 (1966) 1, 279 (1959) Homologous series, pharmacology Psychopharmaka, Anwendung in der 7, 305 (1964) psychosomatischen Medizin Hydrocortisone, effects of structural 10, 530 (1966) alteration on the antiinflammatory Psychopharmaka, strukturelle properties Betrachtungen 5,11 (1963) 9, 129 (1966) Index Vol. 1-15 383

Psychosomatische Medizin, Spectrofiuorometry, physicochemical Anwendung von Psychopharmaka methods in pharmaceutical chemistry 10, 530 (1966) 6, 151 (1963) Psychotomimetic agents Stoffwechsel von Arzneimitteln, Ursache 15,68 (1971) von Wirkung, Nebenwirkung und Toxizitat Quaternary ammonium salts, chemical 15, 147 (1971) nature and pharmacological actions Strahlenempfindlichkeit von Sauge• 2, 135 (1960) tieren, Beeinfiussung durch chemische Quinazolones, biological activity Substanzen 14, 218 (1970) 9,11 (1966) Quinuclidine derivatives, chemical Sulfonamide research structure and pharmacological activity 12, 389 (1968) 13, 293 (1969) Terpenoids, biological activity 6, 279 (1963). 13, 11 (1969) Reproduction in women, pharmacological Thymoleptika, Biochemie und control Pharmakologie 12, 47 (1968) 11, 121 (1968) Rheumatherapie, Synopsis Trichomonasis, Metronidazol-Therapie 12, 165 (1968) 9, 361 (1966) Tuberkulose, antibakterielle Schwefelverbindungen, therapeutisch Chemotherapie verwendbare 7, 193 (1964) 4,9(1962) Shock, medical interpretation Wurmkrankheiten, Chemotherapie 14, 196 (1970) 1, 159 (1959) Index Vol. 1-15 385

AUTHOR AND PAPER INDEX

A UTOREN- UND ARTIKELINDEX

INDEX DES AUTEURS ET DES ARTICLES

Vol. 1-15 (1959-1971)

Pharmacology of Clinically Useful Prof. Dr. R. P. AHLQUIST Beta-Adrenergic Blocking Drugs Professor of Pharmacology, School of Medicine, 15, 103 (1971) Medical College of Georgia, Augusta, Georgia, USA Dr. A. M. KAROW, Jr. Assistant Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA Dr. M. W. RILEY Assistant Professor of Pharmacology, School of Medicine, Medical College of Georgia, Augusta, Georgia, USA

Biological Activity in the Dr. A. H. AM IN Quinazolone Series 14, 218 (1970) Director of Research, Alembic Chemical Works Co. Ltd., Alembic Road, Baroda 3, India Dr. D. R. MEHTA Research Division, Alembic Chemical Works Co. Ltd., Alembic Road, Baroda 3, India Dr. S. S. SAMARTH Research Division, Alembic Chemical \Vorks Co. Ltd., Alembic Road, Baroda 3, India

Reactivity of Rat and Man Dr. S. I. ANKIER to Egg-White 13, 340 (1969) Allen & Hanburys Ltd., Research Division,\Vare, Hertfordshire, England

Narcotic Antagonists Dr. S. ARCHER 8, 261 (1965) Assistant Director of Chemical Research, Ster• ling-Winthrop Research Institute, Rensselaer, New York, USA Dr. L. S. HARRIS Section Head in Pharmacology, Sterling-Win• throp Research Institute, Rensselaer, New York, USA

Molecular Geometry and Mechanism Prof. Dr. J. C. ARCOS of Action of Chemical Carcinogens Department of Medicine and Biochemistry, 4, 407 (1962) Tulane University, U. S. Public Health Service, New Orleans, Louisiana, USA

25 Jucker 15 386 Index Vol. 1-15

Molecular Pharmacology, a Basis Prof. Dr. E. J. ARIENS for Drug Design 10, 429 (1966) Institute of Pharmacology, University of Nijme• Reduction of Drug Action by Drug gen, Nijmegen, Holland Combination 14, 11 (1970)

Neuere Aspekte der chemischen Dr. J. BALLY Anthelminticaforschung 1, 243 (1959) wissenschaftlicher Mitarbeiter der Sandoz AG, Basel, Schweiz

Stereochemical Factors in Biological Prof. Dr. A. H. BECKETT Activity 1, 455 (1959) Head of School of Pharmacy, Chelsea College of Science and Technology, Chelsea, London, England

Newer Diuretics 2, 9 (1960) Dr. K. H. BEYER JR. Vice-President, Merck Sharp and Dohme Re• search Laboratoires, \Vest Point, Pennsylvania, USA Dr. J. E. BAER Director of Pharmacological Chemistry, Merck Institute for Therapeutic Research, West Point, Pennsylvania, USA

Untersuchungen zur Biochemie und Dr. M. H. BICKEL Pharmakologie der Thymoleptika 11, Privatdozent, Medizinisch-Chemisches Institut 121 (1968) der Universitat Bern, Schweiz

The ,B-Adrenergic Blocking Agents, Dr. J. H. BIEL Pharmacology and Structure-Activity Vice-President, Research and Development, Relationships 10, 46 (1966) Aldrich Chemical Company Inc., Milwaukee, Wisconsin, USA Dr. B. K. B. LUM Department of Pharmacology, Marquette Uni• versity School of Medicine, Milwaukee, Wiscon• sin, USA

Die Ionenaustauscher und ihre Prof. Dr. J. BUCHl Anwendung in der Pharmazie und Direktor des Pharmazeutischen Institutes der Medizin 1, 11 (1959) ETH, Zurich, Schweiz Wert und Bewertung der Arznei• mittel 10, 90 (1966)

Cyclopropane Compounds of Prof. Dr. A. BURGER Biological Interest Department of Chemistry, University of Virginia, 15, 227 (1971) Charlottesville, Virginia, USA

Les derives organiques du fluor Prof. Dr. N. P. Buu-Hol d'interet pharmacologique Directeur de Laboratoire a I'Institut de chimie 3,9(1961) des substances naturelles du Centre National de la Recherche Scientifique, Gif-sur-Yvette, France Index Vol. 1-15 387

Anabolic Steroids 2,71 (1960) Prof. Dr. B. CAMERINO Director of the Chemical Research Laboratory of Farmitalia, Milan, Italy Prof. Dr. G. SALA Department of Clinical Chemistry and Medical Pathology, University of Milan, and Director of the Department of Pharmaceutical Therapy, Farmitalia, Milan, Italy

Chemical Nature and Pharmacological Prof. Dr. C. J. CA V ALLITO Actions of Quaternary Ammonium Professor, Medicinal Chemistry, School of Phar• Salts 2, 135 (1960) macy, University of North Carolina, Chapel Hill, N. Carolina, USA Dr. A. P. GRAY Director of the Chemical Research Section, Neisler Laboratones Inc., Decatur, Illinois, USA

Contributions of Medicinal Chemistry Prof. Dr. C. J. CA V ALLITO to Medicine - from 1935 Professor, Medicinal Chemistry, School of Phar• 12, 11 (1968) macy, University of North Carolina, Chapel Hill, N. Carolina, USA

Uber Vorkommen und Bedeutung Dr. A. CERLETTI der Indolstruktur in der Medizin Direktor der medizinisch-biologischen For• und Biologie 2, 227 (1960) schungsabteilung der Sandoz AG, Basel, Schweiz

Cholesterol and Its Relation to Prof. Dr. K. K. CHEN Atherosclerosis I, 127 (1959) Department of Pharmacology, University School of Medicine, Indianapolis, Indiana, USA Dr. TSUNG-MIN LIN Senior Pharmacologist, Division of Pharmaco• logic Research, Lilly Research Laboratories, Indianapolis, Indiana, USA

The Psychotomimetic Agents Dr. S. COHEN IS, 68 (1971) Director, Division of Narcotic Addiction and Drug Abuse, National Institute of Mental Health, Chevy Chase, Maryland, USA

Structure-Activity Relationships Prof. Dr. J. C. CRAIG in Certain Anthelmintics Department of Pharmaceutical Chemistry, Uni• 3, 75 (1961) versity of California, San Francisco, California, USA Dr. M. E. TATE Post Doctoral Fellow, University of New South Wales, Department of Organic Chemistry, Ken• sington, N. S.W., Australia 388 Index Vol. 1-15

Biochemical Effects of Drugs Acting Dr. L. DECSI on the Central Nervous System Specialist in Clinical Chemistry, University 8,53 (1965) Medical School, Pecs, Hungary

Drug Research - Whence and Dr. R, G. DENKEWALTER Whither 10, 11 (1966) Vice-President for Exploratory Research, Merck Sharp & Dohme Research Laboratories\ Rah• way, New Jersey, USA Dr. M. TISHLER President, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA

Aminonucleosid-Nephrose Dr. U. C. DUBACH 7, 341 (1964) Privatdozent, Oberarzt an der Medizinischen Universitats-Poliklinik Basel, Schweiz

Drug-Macromolecular Interactions: Dr. S. EHREN PREIS Implications for Pharmacological Associate Professor and Head Department of Activity 14, 59 (1970) Pharmacology, New York Medical College, Fifth Avenue at 106th Street, New York, N. Y. 10029

Betrachtungen zur Entwicklung von Prof. Dr. G. EHRHART Heilmitteln 10, 33 (1966) Farbwerke Hoechst AG, Frankfurt a.M.-Hochst, BR Deutschland

Progress in Malaria Chemotherapy, Dr. E. F. ELSLAGER Part 1. Repository Antimalarial Group Director, Organic Chemistry, Research Drugs 13, 170 (1969) Laboratories, Parke, Davis & Company, Ann Arbor, Michigan, USA

Recent Research in the Field of 5- Prof. Dr. V. ERSPAMER Hydroxytryptamine and Related Institute of Pharmacology, University of Parma, Indolealkylamines 3, 151 (1961) Parma, Italy

Drug Action and Assay Prof. Dr. E. R. GARRETT by Microbial Kinetics Graduate Research Professor, 75, 271 (1971) The J. Hillis Miller Health Center, College of Pharmacy, University of Florida, Gainesville, Florida, USA

The Chemotherapy of Prof. Dr. L. P. GARROD Enterobacterial Department of Bacteriology, Royal Postgraduate Infections 12, 370 (1968) Medical School, Hammersmith Hospital, Lon• don, England

Metabolism of Drugs and Other Dr. J. R. GILLETTE Foreign Compounds by Enzymatic Head, Section on Enzymes Drug Interaction, Mechanisms 6, 11 (1963) Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda 14, Maryland, USA

Basic Mechanisms of Drug Action Prof. Dr. D. R. H. GOURLEY 7,11 (1964) Department of Pharmacology, Universtiy of Vir• ginia School of Medicine, Charlottesville, Vir• ginia, USA Index Vol. 1-15 389

Zusammenhange zwischen Konsti• Dr. H. GRASSHOF tution und Wirksamkeit bei Lokal• Forschungschemiker in Firma M. Woelm, Esch• anasthetica 4, 353 (1962) wege, Deutschland

Das Placeboproblem Prof. Dr. H. HAAS 1,279 (1959) Leiter der Pharmakologischen Abteilung Knoll AG, Ludwigshafen, und Dozent an der Universi• tat Heidelberg Dr. H. FINK und Dr. G. HARTEFELDER Forschungslaboratorien der Knoll AG, Ludwigs• hafen, Deutschland

Pharmacological Control of Dr. M. J. K. HARPER Reproduction in Women Senior Scientist, The Worcester Foundation for 12,47 (1968) Experimental Biology, Shrewsbury, Massa• chusetts, USA

Drug Latentiation Prof. Dr. N. J. HARPER 4, 221 (1962) Head of the Department of Pharmacy, Univer• sity of Aston, Birmingham 4, England

Chemotherapy of Filariasis Dr. F. HAWKING 9, 191 (1966) Head of the Division of Chemotherapy and Parasitology at the National Institute for Medical Research, London, England

Recent Studies in the Field of Dr. R. V. HEINZELMAN Indole Compounds Section Head, Organic Chemistry, The Upjohn 6,75 (1963) Company, Kalamazoo, Michigan, USA Dr. J. SZMUSZKOVICZ Research Chemist, The Upjohn Company, Kala• mazoo, Michigan, USA

Neuere Entwicklungen auf dem Dr. H. HERBST Gebiete therapeutisch verwendbarer Forschungschemiker in den Farbwerken Hoechst, organischer Schwefelverbindungen Frankfurt a.M., Deutschland 4,9(1962)

The Pharmacology of Homologous Dr. H. R. ING Series 7, 305 (1964) Reader in Chemical Pharmacology, Oxford Uni• versity, and Head of the Chemical Unit of the University Department of Pharmacology, Oxford, England

The Development of Antifertility Prof. Dr. H. JACKSON Substances 7, 133 (1964) Head of Department of Experimental Chemo• therapy, Christie Hospital and Holt Radium Institute, Paterson Laboratories, Manchester 20, England 390 Index Vo!. 1-15

Die Amidinstruktur in der Arzneistoff• Prof. Dr. A. KREUTZ BERGER forschung 11, 356 (1968) Wissenschaftlicher Abteilungsvorsteher am In• stitut fur pharmazeutische Chemie der Westfali• schen Wilhelms-Universitat Munster, Munster (Westfalen), Deutschland

Dber neue Arzneimittel 1, 531 (1959) Dr. W. KUNZ 2, 251 (1960), 3, 369 (1961), Forschungschemiker in Firma Dr. Schwarz 6, 347 (1963), 10, 360 (1966) GmbH, Monheim (Rhein!.), Deutschland

Die Anwendung von Psychopharmaka Dr. F. LAB HARDT in der psychosomatischen Medizin Privatdozent, stellvertretender Direktor der 10, 530 (1966) psychiatrischen Universitatsklinik,Basel, Schweiz

Physico Chemical Methods in Dr. H. G. LEEMANN Pharmaceutical Chemistry, Head of the Analytical Department in the I. Spectrofluorometry Pharmaceutical Division of Sandoz Ltd., Basle, 6, 151 (1963) Switzerland Dr. K. STICH Specialist for Questions in Ultraviolet and Fluorescence Spectrophotometry, Analytical De• partment, Sandoz Ltd., Basle Switzerland Dr. MARGRIT THOMAS Research Chemist in the Analytical Department Research Laboratory, Sandoz Ltd., Basle, Switzerland

Interactions Between Androgenic• Dr. O. LINET Anabolic Steroids and Glucocorticoids Sinai Hospital of Detroit, Department of Medi• 14, 139 (1970) cine, 6767 West Outer Drive, Detroit, Michigan 48235

Biological Activity of the Dr. M. MARTIN-SMITH Terpenoids and Their Derivatives Reader in Pharmaceutical Chemistry, University 6, 279 (1963) of Strathclyde, Department of Pharmaceutical Chemistry, Glasgow C. 1, Scotland Dr. T. KHATOON Lecturer in Chemistry at the Eden Girls College, Dacca, East Pakistan

Biological Activity of the Dr. M. MARTIN-SMITH Terpenoids and Their Reader in Pharmaceutical Chemistry, University Derivatives - Recent of Strathclyde, Glasgow, C. 1, Scotland Advances 13, 11 (1969) Dr. W. E. SNEADER Lecturer in Pharmaceutical Chemistry, Univer• sityof Strathclyde, Glasgow, C. 1, Scotland

Antihypertem'ive Agents Prof. Dr. A. MARxER 1962-19f8 CIBA Limited, Basle, Switzerland 13,101 ,g'69) Dr. O. SCHIER CIBA Limited, Basle, Switzerland Index Vol. 1-15 391

Relationships Between the Prof. Dr. M. D. MASHKOVSKY Chemical Structure and All-Union Chemical Pharmac;;eutical Research Pharmacological Activity Institute, Moscow, USSR in a Series of Synthetic Dr. L. N. Y AKHONTOV Quinuclidine Derivatives All-Union Chemical Pharmaceutical Research 13, 293 (1969) Institute, Moscow, USSR

On the Understanding of Drug Potency Dr. J. W. McFARLAND 15, 123 (1971) Pfizer Medical Research Laboratories, Groton Connecticut, USA

Zur Beeinflussung der Strahlen• Dr. H.-J. MELCHING empfindlichkeit von Saugetieren Privatdozent, Oberassistent am Radiologischen durch chemische Substanzen Institut der Universitat Freiburg i. Br., Freiburg 9,11 (1966) i. Br., Deutschland Dr. C. STREFFER Wissenschaftlicher Mitarbeiter am Radiologi• schen Institut der Universitat Freiburg i. Br., Freiburg i. Br., Deutschland

Analgesia and Addiction Dr. L. B. MELLETT 5, 155 (1963) Assistant Professor of Pharmacology, University of Michigan Medical School, Ann Arbor, Michi• gan, USA Prof. Dr. L. A. WOODS Department of Pharmacology, College of Medi• cine, State University of Iowa, Iowa City, USA

Comparative Drug Dr. L. B. MELLETT Metabolism Head, Pharmacology & Toxicology, Kettering• 13, 136 (1969) Meyer Laboratories, Southern Research Insti• tute, Birmingham, Alabama, USA

Synopsis der Rheumatherapie Dr. W. MOLL 12, 165 (1968) Spezialarzt FMH Innere Medizin - Rheumatolo• gie, Basel, Schweiz

On the Chemotherapy of Cancer Dr. J. A. MONTGOMERY 8, 431 (1965) Head of the Organic Chemistry Division, South• ern Research Institute, Kettering-Meyer Labo• ratory, Birmingham 5, Alabama, USA

Der Einfluss der Formgebung auf Prof. Dr. K. MUNZEL die Wirkung eines Arzneimittels Leiter der galenischen Forschungsabteilung der 10, 204 (1966) F. Hoffmann-La Roche & Co. AG, Basel, Schweiz Galenische Formgebung und Arzneimittelwirkung. Neue Erkenntnisse und Feststellungen 14, 269 (1970)

Ganglienblocker Dr. K. NADOR 2, 297 (1960) o. Professor und Institutsdirektor, Chemisches Institut der Tierarztlichen U niversitat, Budapest, Ungarn 392 Index Vol. 1-15

Die Chemotherapie der Wurm• Prof. Dr. H.-A. OELKERS krankheiten I, 159 (1959) Leiter der pharmakologischen und parasitologi• schen Abteilung der Firma C. F. Asche & Co., Hamburg-Altona, Deutschland

3,4-Dihydroxyphenylalanine and Dr. A. R. PATEL Related Compounds 9, 223 (1966) Post-Doctoral Research Assistant, Department of Chemistry, University of Virginia, Charlottes• ville, Virginia, USA Proi. Dr. A. BURGER Department of Chemistry, University of Vir• ginia, Charlottesville, Virginia, USA

Mescaline and Related Compounds Dr. A. R. PATEL 11, 11 (1968) Post-Doctoral Research Assistant, Department of Chemistry, Universtiy of Virginia, Charlottes• ville, Virginia, USA

Monoaminoxydase-Hemmer Prof. Dr. A. PLETSCHER 2, 417 (1960) Direktor der medizinischen Forschungsabteilung F. Hoffmann-La Roche & Co. AG, Basel, und Professor fur Innere Medizin an der Universitat Basel Dr. K. F. GEY Medizinische Forschungsabteilung F. Hoffmann• La Roche & Co. AG, Basel, Schweiz Dr. P. ZELLER Chefchemiker in Firma F. Hoffmann-La Roche & Co. AG, Basel, Schweiz

The Photochemistry of Drugs and Dr. S. T. REID Related Substances 11,48 (1968) Lecturer in Chemical Pharmacology, Experi• mental Pharmacology Division, Institute ofPhys• iology, The University, Glasgow, W.2, Scotland

Orale Antikoagulantien Dr. E. RENK 11, 226 (1968) Wissenschaftliche Laboratorien der J. R. Geigy AG, Basel, Schweiz Dr. W. G. STOLL Wissenschaftliche Laboratorien der J. R. Geigy AG, Basel, Schweiz

The Effects of Structural Alteration Dr. L. H. SARETT on the Anti-Inflammatory Director of Synthetic Organic Chemistry, Merck Properties of Hydrocortisone Sharp & Dohme Research Laboratories, Rahway, 5,11 (1963) New Jersey, USA Dr. A. A. PATCHETT Director of the Department of Synthetic Organic Chemistry, Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey, USA Dr. S. STEELMAN Director of Endocrinology, Merck Institute for Therapeutic Research, Rahway, New Jersey, USA Index Vol. 1-15 393

Phenothiazine und Azaphenothiazine Dr. E. SCHENKER als Arzneimittel 5, 269 (1963) Forschungschemiker in der Sandoz AG, Basel, Schweiz Dr. H. HERBST Forschungschemiker in den Farbwerken Hoechst, Frankfurt a.M., Deutschland

Antihypertensive Agents Dr. E. SCHLlTTLER 4, 295 (1962) Director of Research of CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. J. DRUEY Director of the Department of Synthetic Drug Research of CIBA Ltd., Basle, Switzerland Dr. A. MARXER Research Chemist of CIBA Ltd., Basle, and Lec• turer at the University of Berne, Switzerland

Die Anwendung radioaktiver Isotope Prof. Dr. K. E. SCHULTE in der pharmazeutischen Forschung Direktor des Instituts fur Pharmazie und Lebens• 7,59 (1964) mittelchemie der Westfalischen Wilhelms-Uni• versitat Munster, Munster (Westf.), Deutschland Dr. INGEBORG MLEINEK Leiterin des Isotopen-Laboratoriums, Institut fur Pharmazie und Lebensmittelchemie der Westfalischen Wilhelms-Universitat Munster, Munster (Westf.), Deutschland

Naturliche und synthetische Acetylen• Prof. Dr. K. E. SCHULTE Verbindungen als Arzneistoffe Direktor des Instituts fur pharmazeutische Che• 14, 387 (1970) mie der Westfalischen Wilhelms-Universitat MUnster, MUnster (Westf.), Deutschland Dr. G. RUCKER Dozent fUr pharmazeutische Chemie an der West• falischen Wilhelms-Universitat MUnster, MUn• ster (Westf.), Deutschland

The Structure and Biogenesis of Dr. W. A. SEXTON Certain Antibiotics 2, 591 (1960) Research Director of the Pharmaceuticals Divi• sion of Imperial Chemical Industries Ltd., Wilmslow, Cheshire, England

Ayurvedic Medicine - Past and Present Dr. SHIV SHARMA 15, 11 (1971) 'Baharestan', Bomanji Petit Road, Cumballa Hill, Bombay, India

The Biliary Excretion and Dr. R. L. SMITH Enterohepatic Circulation of Drugs Senior Lecturer in Biochemistry at St. Mary's and Other Organic Compounds Hospital Medical School (University of London), g, 299 (1966) Paddington, London, W.2, England 394 Index Vol. 1-15

Strukturelle Betrachtungen der Dr. K. STACH Ps ychopharmaka: Versuch einer Stellvertretender Leiter der Chemischen For• Korrelation von chemischer schung der C. F. Boehringer & Si:ihne GmbH, Konstitution und klinischer Mannheim-Waldhof, Deutschland Wirkung g, 129 (1966) Dr. VV. Pi:iLDINGER Oberarzt fur klinische Psychopharmakologie an der Psychiatrischen Universitatsklinik Basel, Basel, Schweiz

Hypolipidemic Agents Dr. G. DE STEVENS 13,217 (1969) Vice President and Director of Research, CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. W. L. BENczE Research Department, CIBA Pharmaceutical Company, Summit, New Jersey, USA Dr. R. HEss CIBA Limited, Basle, Switzerland

Progress in Sulfonamide Dr. T. STRULLER Research Department of Clinical Research and Depart• 12, 389 (1968) ment of Product Development, F. Hoffmann• La Roche & Co. Ltd., Basle, Switzerland

Antiarrhythmic Compounds Prof. Dr. L. SZEKERES 12, 292 (1968) Head of the Department of Pharmacology, School of Medicine, University of Szeged, Szeged, Hungary Dr. J. G. PAPP Senior Lecturer, University Department of Pharmacology, Oxford, England

Practically Applicable Results Prof. Dr. M. TAUSK of Twenty Years of Research State Universtiy of Utrecht, in Endocrinology Faculty of MedIcine, 12, 137 (1968) Utrecht, Netherlands

Antibakterielle Chemotherapie der Dr. F. TRENDELENBURG Tuberkulose 7, 193 (1964) Leitender Arzt der Robert-Koch-Abteilung der Medizinischen Universitatskliniken, Hornburg, Saar, Deutschland

Biologische Oxydation und Reduktion Prof. Dr. H. UEHLEKE am Stickstoff aromatischer Amino- Pharmakologisches lnstitut der Universitat Tu• und Nitroderivat und ihre Folgen bingen, 74 Tubingen, Deutschland fUr den Organismus 8, 195 (1965) Stoffwechsel von Arzneimitteln als Ursache von Wirkungen, Nebenwirkun• gen und Toxizitat 15, 147 (1971)

A Pharmacological Approach to Dr. G. B. WEST Allergy 3, 409 (1961) Reader in the School of Pharmacy, Department of Pharmacology, University of London, London, England Index Vol. 1-15 395

A New Approach to the Medical Dr. G. B. WEST Interpretation of Shock Scientific Secretary, The British Industrial Bio• 14, 196 (1970) logical Research Association, Woodmansterne Road, Carshalton, Surrey, England. Dr. M. S. STARR Department of Pharmacology, St. Mary's Hospi• tal Medical School, University of London, Lon• don, England

Some Biochemical and Dr. M. W. WHITEHOUSE Pharmacological Properties of Anti• Lecturer in Biochemistry at the University of Inflammatory Drugs 8, 321 (1965) Oxford, Oxford, England

Wirksamkeit und Nebenwirkungen Dr. K. WIESNER von Metronidazol in der Therapie Tierarzt, Wissenschaftlicher Mitarbeiter der der Trichomonasis g, 361 (1966) Pharma-wissenschaftlichen Literaturabteilung, Farbenfabriken Bayer AG, Leverkusen, Deutsch• land Dr. H. FINK Leiter der Pharma-wissenschaftlichen Literatur• abteilung, Farbenfabriken Bayer AG, Lever• kusen, Deutschland

Nonsteroid Antiinflammatory Dr. C. A. WINTER Agents 10, 139 (1966) Senior Investigator Pharmacology, Merck Insti• tute for Therapeutic Research, vVest Point, Pennsylvania, USA

Basic Research in the US Pharma• Dr. O. WINTERSTEINER ceutical Industry 15, 204 (1971) The Squibb Institute for Medical Research, New Brunswick, New Jersey, USA

The Chemotherapy of Amoebiasis Dr. G. WOOLFE 8, 11 (1965) Head of the Chemotherapy Groupofthe Research Department at Boots Pure Drug Company Ltd., Nottingham, England

Antimetabolites and Their Dr. D. W. WOOLLEY Revolution in Pharmacology The Rockefeller Institute, New York, USA 2, 613 (1960)

Krebswirksame Antibiotika aus Dr. KH. ZEPF Actinomyceten 3, 451 (1961) Forschungschemiker im biochemischen und mikrobiologischen Laboratorium der Farbwerke Hoechst, Frankfurt a.M., Deutschland Dr. CHRISTA ZEPF Referentin fur das Chemische Zentralblatt, Kelk• heim (Taunus), Deutschland