Supplementary Table I. Oligonucleotide Microarray Analysis of Mrna from Sev- Versus Sev-UV-Inoculated Primary-Culture Mtecs As Described in the Legend to Fig

Home , Urokinase receptor

Supplementary Table I. Oligonucleotide microarray analysis of mRNA from SeV- versus SeV-UV-inoculated primary-culture mTECs as described in the legend to Fig. 1.

Probeset Log Fold- Adjusted Gene Symbol Gene Title IFN- Reference Category Fold- change P Value responsive. Change or Antiviral 98518_f_at 4.17 18.01 0.00885 Crct1 cysteine-rich C-terminal 1 No Not reported Not yet identified 104217_at 3.89 14.84 0.00477 Gdpd3 glycerophosphodiester No Not reported Not yet identified phosphodiesterase domain containing 3 103391_at 3.42 10.7 0.00536 Ccbl2 cysteine conjugate-beta No Not reported Not yet identified lyase 2 92388_at 3.05 8.29 0.0431 Cox18 COX18 cytochrome c No Not reported Not yet identified oxidase assembly homolog (S. cerevisiae) 94928_at 2.93 7.62 0.00922 Tnfrsf1b tumor necrosis factor No Not reported Not yet identified receptor superfamily, member 1b 160119_at 2.44 5.43 0.0405 Creld2 cysteine-rich with EGF-like No Not reported Not yet identified domains 2 104252_at 2.44 5.42 0.0104 AU020206 expressed sequence No Not reported Not yet identified AU020206 104351_at 2.19 4.57 9.55E-006 Gmppb GDP-mannose No Not reported Not yet identified pyrophosphorylase B 99032_at 2.16 4.46 0.00224 Rasd1 RAS, dexamethasone- No Not reported Not yet identified induced 1 102712_at 2.07 4.19 0.000586 Saa3 serum amyloid A 3 No Not reported Not yet identified

104333_at 1.97 3.91 0.000113 D17H6S56E-5 DNA segment, Chr 17, No Not reported Not yet identified human D6S56E 5 104645_at 1.86 3.62 0.0337 Klf7 Kruppel-like factor 7 No Not reported Not yet identified (ubiquitous) 99849_at 1.71 3.28 0.0353 Wdr92 WD repeat domain 92 No Not reported Not yet identified 161433_f_at 1.69 3.22 0.0244 Piga phosphatidylinositol glycan No Not reported Not yet identified anchor biosynthesis, class A 98572_at 1.5 2.83 0.0163 Dnajb11 DnaJ (Hsp40) homolog, No Not reported Not yet identified subfamily B, member 11 92730_at 1.46 2.76 0.014 Hbegf heparin-binding EGF-like No Not reported Not yet identified growth factor 102316_at 1.42 2.68 0.016 Capn5 calpain 5 No Not reported Not yet identified 103531_f_at 1.36 2.56 0.0377 Ero1lb ERO1-like beta (S. No Not reported Not yet identified cerevisiae) 95473_s_at 1.07 2.11 0.0359 Bud31 BUD31 homolog (yeast) No Not reported Not yet identified 160082_s_at 1.07 2.1 0.0359 Arf4 ADP-ribosylation factor 4 No Not reported Not yet identified

103995_at 1.05 2.07 0.0359 Fgfbp1 fibroblast growth factor No Not reported Not yet identified binding protein 1 94826_at 1.04 2.06 0.0468 Eif6 eukaryotic translation No Not reported Not yet identified initiation factor 6 102812_i_at 1.01 2.01 0.0192 Ube1dc1 ubiquitin-activating enzyme No Not reported Not yet identified E1-domain containing 1 102340_at 1 2 0.00922 Mina myc induced nuclear No Not reported Not yet identified antigen 160220_at 0.84 1.79 0.035 Zfp110 zinc finger protein 110 No Not reported Not yet identified

161006_at 0.8 1.74 0.00947 Slco3a1 solute carrier organic anion No Not reported Not yet identified transporter family, member 3a1 98984_f_at 0.79 1.73 0.00245 Gpd2 glycerol phosphate No Not reported Not yet identified dehydrogenase 2, mitochondrial 102098_at 0.68 1.6 0.0227 ------No Not reported Not yet identified 101061_at 0.63 1.55 0.0135 Ssr2 signal sequence receptor, No Not reported Not yet identified beta 98406_at 7.12 139.29 0.000672 Ccl5 chemokine (C-C motif) Yes (1) Cytokine / Chemokine ligand 5 Signaling 103202_at 6.44 86.6 0.000157 Gbp3 guanylate nucleotide Yes (2) Directly Antiviral binding protein 3 102965_at 6.06 66.8 7.5E-005 Znfx1 zinc finger, NFX1-type Yes (3) Transcription containing 1 104597_at 6.05 66.27 0.000202 Gbp2 guanylate nucleotide Yes (4) Directly Antiviral binding protein 2 95349_g_at 5.54 46.62 9.17E-005 Cxcl1 chemokine (C-X-C motif) Yes (4) Cytokine / Chemokine ligand 1 Signaling 103066_at 5.54 46.52 9.55E-006 Tyki thymidylate kinase family Yes (3) Unknown LPS-inducible member 160933_at 5.52 45.89 2.07E-005 Igtp interferon gamma induced Yes (5) Directly Antiviral GTPase 93956_at 5.52 45.86 2.94E-006 Ifit3 interferon-induced protein Yes (4) Other Immune with tetratricopeptide Response repeats 3 98417_at 5.04 32.84 2.39E-005 Mx1 myxovirus (influenza virus) Yes (4) Directly Antiviral resistance 1 100981_at 5.04 32.79 0.000167 Ifit1 interferon-induced protein Yes (4) Other Immune with tetratricopeptide Response repeats 1 100944_at 4.99 31.77 2.07E-005 AW112010 expressed sequence Yes (6) Unknown AW112010

104177_at 4.91 30.1 0.000241 Rsad2 radical S-adenosyl Yes (4) Directly Antiviral methionine domain containing 2 94224_s_at 4.85 28.75 1.45E-005 Ifi203 /// Ifi205 /// interferon activated gene Yes (4, 7-9) Transcription LOC100040462 203 /// similar to interferon /// activated gene 205 /// LOC100044072 interferon activated gene /// 205 /// myeloid cell nuclear LOC100048634 differentiation antigen /// /// LOC192690 similar to Interferon- /// LOC640890 activatable protein 205 (IFI- /// Mnda 205) (D3 protein) /// similar to interferon-activatable protein /// similar to Interferon-activable protein 204 (Ifi-204) (Interferon- inducible protein p204) 96764_at 4.82 28.19 9.24E-005 Iigp1 interferon inducible GTPase Yes (10) Directly Antiviral 1 99071_at 4.77 27.26 0.00157 Mpeg1 macrophage expressed Yes (6) Other Immune gene 1 Response 102699_at 4.64 24.98 6.63E-005 Mx2 myxovirus (influenza virus) Yes (4) Directly Antiviral resistance 2 103446_at 4.57 23.7 0.00494 Ifih1 interferon induced with Yes (4) Transcription helicase C domain 1 102906_at 4.43 21.51 0.000663 Tgtp T-cell specific GTPase /// Yes (5, 11) Directly Antiviral hypothetical protein LOC100039796 101160_at 4.4 21.11 2.94E-006 Cxcl2 chemokine (C-X-C motif) Yes (4) Cytokine / Chemokine ligand 2 Signaling 93617_at 4.1 17.15 0.000179 Ccrl2 chemokine (C-C motif) Yes (12) Cytokine / Chemokine receptor-like 2 Signaling 102791_at 4.09 17.08 0.000113 Psmb8 proteasome (prosome, Yes (4) Protein Modification macropain) subunit, beta type 8 (large multifunctional peptidase 7) 103035_at 4.08 16.93 3.47E-005 Tap1 transporter 1, ATP-binding Yes (4) Other Immune cassette, sub-family B Response (MDR/TAP) 103080_at 4.06 16.63 0.00121 Samhd1 SAM domain and HD Yes (4) Other Immune domain, 1 Response 93858_at 3.95 15.41 0.000933 Cxcl10 chemokine (C-X-C motif) Yes (4) Cytokine / Chemokine ligand 10 Signaling 161511_f_at 3.86 14.55 0.00299 LOC677168 similar to ISG15 ubiquitin- Yes isg15-like Protein Modification like modifier 98410_at 3.78 13.74 0.0134 Iigp2 interferon inducible GTPase Yes (10) Directly Antiviral 2 94774_at 3.71 13.06 0.00187 Ifi202b interferon activated gene Yes (8) Other Immune 202B Response 95024_at 3.63 12.36 0.000998 Usp18 ubiquitin specific peptidase Yes (4) Protein Modification 18 /// similar to ubiquitin specific protease UBP43 104165_at 3.6 12.14 0.00219 Vnn1 vanin 1 Yes (13) Unknown

104156_r_at 3.47 11.05 0.000162 Atf3 activating transcription Yes (4) Transcription factor 3 93865_s_at 3.36 10.3 9.24E-005 H2-T10 /// H2- histocompatibility 2, T Yes (14) MHC T22 /// H2-T9 /// region locus 10 /// LOC100044190 histocompatibility 2, T /// region locus 22 /// LOC100044191 histocompatibility 2, T region locus 9 /// hypothetical protein LOC100044190 /// hypothetical protein LOC100044191 93321_at 3.34 10.14 0.000246 Ifi203 interferon activated gene Yes (7) Other Immune 203 Response

101848_g_at 3.25 9.52 0.00227 Sp100 nuclear antigen Sp100 Yes (4) Transcription

93088_at 3.2 9.21 0.000576 B2m beta-2 microglobulin Yes (4) MHC 104181_at 3.19 9.13 7.5E-005 Vnn3 vanin 3 Yes (13) Unknown 162202_f_at 3.09 8.53 5.09E-005 Irf7 interferon regulatory factor Yes (4) Transcription 7 104750_at 3.09 8.49 0.0286 Ifi47 interferon gamma inducible Yes (15) Other Immune protein 47 Response

103639_at 3.01 8.05 7.5E-005 Ifit2 interferon-induced protein Yes (4) Other Immune with tetratricopeptide Response repeats 2 98438_f_at 2.96 7.81 0.0379 H2-Q7 histocompatibility 2, Q Yes (4) MHC region locus 7

100882_at 2.85 7.19 0.000552 Defb1 defensin beta 1 Yes (16) Other Immune Response 92471_i_at 2.76 6.75 0.0038 Slfn2 schlafen 2 Yes (3, 17) Unknown 97540_f_at 2.73 6.62 0.0119 H2-D1 histocompatibility 2, D Yes (14) MHC region locus 1 98465_f_at 2.72 6.58 6.63E-005 Ifi204 /// interferon activated gene Yes (4, 7-9) Transcription LOC100044072 204 /// similar to Interferon- /// activable protein 204 (Ifi- LOC100048309 204) (Interferon-inducible protein p204) /// similar to interferon activated gene 204 97409_at 2.66 6.32 7.68E-005 Irgm immunity-related GTPase Yes (15, 18) Directly Antiviral family, M 102161_f_at 2.64 6.25 0.00219 H2-D1 /// H2-K1 histocompatibility 2: D Yes (9, 14) MHC /// H2-L /// H2- region locus 1 K1, K region T22 /// H2-T23 D region T region locus 22 /// H2-T9 /// T region locus 23 T region LOC100044190 locus 9 /// similar to MHC /// class I antigen precursor /// LOC100044191 similar to MHC class I /// LOC547349 antigen /// similar to H-2 /// LOC630294 class I histocompatibility /// LOC676708 antigen, L-D alpha chain precursor /// hypothetical protein LOC100044190 /// hypothetical protein LOC100044191 98466_r_at 2.58 6 0.000452 Ifi204 interferon activated gene Yes (4, 9) Transcription 204 102279_at 2.55 5.85 0.00219 Ube1l ubiquitin-activating enzyme Yes (19) Protein Modification E1-like 101465_at 2.53 5.78 0.000276 Stat1 signal transducer and Yes (4, 9) Transcription activator of transcription 1 160253_at 2.51 5.7 0.0315 Ifitm3 interferon induced Yes (4) Other Immune transmembrane protein 3 Response 92942_at 2.48 5.56 0.0241 Trim21 tripartite motif protein 21 Yes (4) Other Immune Response 98083_at 2.47 5.56 0.0423 Klf6 Kruppel-like factor 6 Yes (4) Transcription 102905_at 2.46 5.51 5.09E-005 Casp4 /// caspase 4, apoptosis- Yes (4) Apoptosis LOC100044206 related cysteine peptidase /// hypothetical protein LOC100044206 100013_at 2.44 5.44 0.00137 Ifi35 interferon-induced protein Yes (4, 9) Other Immune 35 Response 102255_at 2.44 5.42 2.01E-005 Osmr oncostatin M receptor Yes (20) Cytokine / Chemokine Signaling 92689_at 2.41 5.33 7.5E-005 Il18bp interleukin 18 binding Yes (9, 21, 22) Cytokine / Chemokine protein Signaling 98472_at 2.33 5.01 0.00919 H2-T23 histocompatibility 2, T Yes (4, 9) MHC region locus 23 /// RIKEN cDNA C920025E04 gene 93714_f_at 2.28 4.86 0.00866 LOC636948 similar to H-2 class I Yes (14) MHC histocompatibility antigen, D-B alpha chain precursor (H-2D(B)) 102053_at 2.25 4.74 0.00245 Plscr2 phospholipid scramblase 2 Yes (4, 9) Other Immune Response

160489_at 2.17 4.51 0.0123 Tnfaip2 tumor necrosis factor, Yes (9) Other Immune alpha-induced protein 2 Response 93425_at 2.17 4.49 8.3E-006 Irf5 interferon regulatory factor Yes (23) Transcription 5 101429_at 2.16 4.46 7.68E-005 Ddit3 DNA-damage inducible Yes (24) Apoptosis transcript 3 101886_f_at 2.16 4.46 0.0137 H2-D1 histocompatibility 2, D Yes (4) MHC region locus 1 100022_at 2.14 4.41 0.0337 Cish cytokine inducible SH2- Yes (25) Cytokine / Chemokine containing protein Signaling 92251_f_at 2.06 4.17 0.00159 AI607873 expressed sequence Yes (14) Transcription AI607873 103254_at 2.02 4.06 0.0418 Trafd1 TRAF type zinc finger Yes (4) Cytokine / Chemokine domain containing 1 Signaling 160463_at 1.97 3.93 0.000162 Myd116 myeloid differentiation Yes (26) Apoptosis primary response gene 116

99915_at 1.97 3.92 0.00486 Areg amphiregulin Yes (27) Growth Factor

97125_f_at 1.92 3.79 0.0342 H2-K1 histocompatibility 2, K1, K Yes (4) MHC region 96752_at 1.91 3.75 0.000731 Icam1 intercellular adhesion Yes (4, 9) Other Immune molecule 1 Response 101510_at 1.85 3.62 0.0497 Psme1 proteasome (prosome, Yes (4) Protein Modification macropain) 28 subunit, alpha 102804_at 1.82 3.53 0.0022 Ceacam1 /// CEA-related cell adhesion Yes (4) Other Immune Ceacam2 molecule 1 /// CEA-related Response cell adhesion molecule 2 160092_at 1.81 3.51 0.0407 Ifrd1 interferon-related Yes (28) Transcription developmental regulator 1 103432_at 1.78 3.43 0.021 Isg20 interferon-stimulated Yes (4) Directly Antiviral protein 99934_at 1.73 3.31 0.0007 Pvrl2 poliovirus receptor-related 2 Yes (29) Other Immune Response 98398_s_at 1.69 3.23 0.000453 Apobec1 apolipoprotein B editing Yes (14) Directly Antiviral complex 1

161650_at 1.66 3.15 0.0315 Slpi secretory leukocyte Yes (30) Directly Antiviral peptidase inhibitor

102401_at 1.61 3.05 0.0132 Irf1 interferon regulatory factor Yes (4, 9) Transcription 1 93981_at 1.57 2.96 9.23E-005 Plat plasminogen activator, Yes (31) Other Immune tissue Response 98822_at 1.54 2.91 0.00708 Isg15 /// ISG15 ubiquitin-like Yes (32, 33) Protein Modification LOC100038882 modifier /// hypothetical /// protein LOC100038882 /// LOC100044225 hypothetical protein LOC100044225 102736_at 1.49 2.81 0.0163 Ccl2 chemokine (C-C motif) Yes (34, 35) Cytokine / Chemokine ligand 2 Signaling

95414_i_at 1.47 2.77 0.0219 C1r complement component 1, r Yes (4) Other Immune subcomponent Response 96117_r_at 1.47 2.77 0.0315 H13 histocompatibility 13 Yes (4, 9) MHC

96533_at 1.42 2.68 0.0337 Tor3a torsin family 3, member A Yes (14, 36) Unknown 103770_at 1.42 2.67 0.00185 2310014L17Rik RIKEN cDNA 2310014L17 Yes (37) Unknown gene 100154_at 1.39 2.62 0.0007 Tapbp TAP binding protein Yes (4) Other Immune Response

102629_at 1.36 2.57 0.00687 Tnf tumor necrosis factor Yes (38) Cytokine / Chemokine Signaling 97507_at 1.36 2.56 0.00133 Lgals3bp lectin, galactoside-binding, Yes (4) Other Immune soluble, 3 binding protein Response 103335_at 1.33 2.52 0.00936 Lgals9 lectin, galactose binding, Yes (39-42) Other Immune soluble 9 Response 161337_f_at 1.15 2.22 0.0381 Wars tryptophanyl-tRNA Yes (4) Transcription synthetase /// similar to Wars protein 162372_f_at 1.15 2.22 0.0169 Relb avian reticuloendotheliosis Yes (43, 44) Transcription viral (v-rel) oncogene related B 96188_at 1.14 2.21 0.0165 Adar adenosine deaminase, Yes (4) Transcription RNA-specific 100588_at 1.11 2.16 0.0288 Psme2 proteasome (prosome, Yes (4) Protein Modification macropain) 28 subunit, beta 93078_at 1.11 2.16 0.000764 Ly6a lymphocyte antigen 6 Yes (45, 46) Other Immune complex, locus A Response 102663_at 1.1 2.15 0.0241 Plaur plasminogen activator, Yes (47, 48) Other Immune urokinase receptor Response 101060_at 1.1 2.14 0.00249 Pdia3 protein disulfide isomerase Yes (49) Other Immune associated 3 Response 160564_at 1.07 2.1 0.0181 Lcn2 lipocalin 2 Yes (50) Cytokine / Chemokine Signaling 101995_at 1.03 2.05 0.0114 Sqstm1 sequestosome 1 Yes (51) Protein Modification 104647_at 1.01 2.02 0.0337 Ptgs2 (COX-2) prostaglandin-endoperoxide Yes (52) Other Immune synthase 2 Response 92315_at 0.95 1.93 0.035 Slfn4 schlafen 4 Yes (3, 17) Unknown 99378_f_at 0.92 1.89 0.00326 LOC436493 similar to MHC class I Yes (14) MHC histocompatibility antigen H-2 Q4 alpha chain precursor - mouse 98773_s_at 0.88 1.84 0.00477 Irg1 immunoresponsive gene 1 Yes (53) Other Immune Response 101450_at 0.87 1.83 0.0462 Csf1 colony stimulating factor 1 Yes (4) Growth Factor (macrophage) 95423_at 0.82 1.77 0.0196 Pdia4 protein disulfide isomerase Yes (54) Other Immune associated 4 Response 103634_at 0.71 1.63 0.0431 Isgf3g interferon dependent Yes (4) Transcription positive acting transcription factor 3 gamma 98579_at 0.67 1.59 0.0431 Egr1 early growth response 1 Yes (55, 56) Transcription 93097_at 0.66 1.58 0.0337 Arg1 arginase 1, liver Yes (3) Other Immune Response 94145_at 0.62 1.54 0.00536 Ifnb1 interferon beta 1, fibroblast Yes (57) Cytokine / Chemokine Signaling References 1. 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