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Home , Aldolase C, SAR1A, Sulfatase, Urokinase receptor

Table S3: List of EGFR pathway-regulated . Name Fold Fold

EGF4h/Control EGF12h/Control Up-regulated by EGFR activation Increased at 4 hours but declined at 12 hours A kinase (PRKA) anchor (gravin) 12 7.67 1.58 Ab2-427 3.05 0.99 acyl-CoA synthetase long-chain family member 1 3.88 0.94 acyl-CoA synthetase long-chain family member 4 6.25 3.58 adipose differentiation-related protein 5.46 3.51 Aldehyde dehydrogenase family 1, subfamily A3 38.45 1.78 amphiregulin 77.79 27.77 arginase 1 4.10 2.06 arginosuccinate synthetase 3.00 1.19 aryl hydrocarbon receptor 5.03 1.55 ATPase, Ca++ transporting, plasma membrane 1 4.08 2.31 basic helix-loop-helix domain containing, class B2 7.86 4.12 Basophilic leukemia expressed sequence 06 (Bles06) 2.89 1.17 BH3 interacting domain death agonist 3.09 1.17 -specific angiogenesis inhibitor 1-associated protein 2 7.73 2.80 breast anti-estrogen resistance 3 (predicted) 3.71 1.85 bridging integrator 1 6.07 2.08 cellular retinoic acid binding protein 2 2.47 1.11 charged rich leucine zipper 1 (predicted) 2.22 1.25 chemokine (C-C motif) ligand 2 3.29 1.34 chemokine (C-C motif) ligand 20 5.91 0.98 Chemotactic protein-3 3.82 -2.1 cryptochrome 1 (-like) 2.99 0.51 cyclin H 2.26 1.34 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.25 1.25 cysteine knot superfamily 1, BMP antagonist 1 20.20 3.28 cytokine receptor-like factor 1 (predicted) 5.43 1.23 death-associated kinase 2 (predicted) 5.03 3.07 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (predicted) 2.46 1.38 decay accelarating factor 1 5.85 2.82 dehydrogenase/reductase (SDR family) member 9 3.22 1.13 diphtheria toxin receptor 9.99 5.16 dual specificity 5 29.54 12.07 early growth response 2 7.99 2.54 endothelial differentiation sphingolipid G-protein-coupled receptor 1 6.05 1.05 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 3.03 1.36 endothelin receptor type A 2.59 0.57 eukaryotic translation initiation factor 4E 2.41 1.29 FK506 binding protein 5 (predicted) 10.11 3.03 FMS-like tyrosine kinase 1 3.74 1.51 follistatin 10.82 6.51 forkhead box P1 (predicted) 2.83 1.27 fos-like antigen 1 41.47 8.70 glutamate-rich WD repeat containing 1 (predicted) 2.59 1.07 glutaredoxin 1 (thioltransferase) 4.13 2.08 Guanosine monophosphate reductase 2 3.09 1.12 heat shock protein 2 2.85 0.50 2 20.80 1.69 high mobility group AT-hook 1 6.40 4.28 homer homolog 1 (Drosophila) 2.35 1.36 hormone-regulated proliferation-associated 20 kDa protein 3.00 1.20 hyaluronan synthase 2 8.46 3.38 IBR domain containing 3 (predicted) 2.57 1.15 keratinocytes proline-rich protein 5.03 3.20 kinesin family member C3 (predicted) 4.60 2.35 leucine-rich repeat-containing 5 (predicted) 2.69 1.05 leukemia inhibitory factor 2.33 1.30 linker of T-cell receptor pathways 6.74 2.70 Ly1 antibody reactive clone (predicted) 3.47 1.92 lysosomal trafficking regulator 5.22 1.41 met proto-oncogene 3.61 1.64 methionine adenosyltransferase II, alpha 2.41 1.07 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 2.86 1.11 myelocytomatosis viral oncogene homolog (avian) 4.56 2.69 myeloid cell nuclear differentiation antigen (predicted) 27.09 12.32 myosin IE 5.16 2.54 myosin IG (predicted) 4.94 3.25 myeloid differentiation primary response gene 116 2.68 1.31 nerve growth factor, beta 7.88 1.66 Notch gene homolog 1, (Drosophila) 3.41 1.21 Notch-regulated ankyrin repeat protein (predicted) 4.47 1.17 nucleolar and coiled-body phosphoprotein 1 2.62 1.34 Nucleoporin like 1 3.98 1.96 oxidized low density lipoprotein (lectin-like) receptor 1 10.30 1.52 peptidylprolyl isomerase F (cyclophilin F) 2.66 0.94 Phosphoribosyl pyrophosphate amidotransferase 3.45 1.39 plasminogen activator, receptor 21.00 7.15 pleckstrin homology, Sec7 and coiled-coil domains 3 8.18 1.91 pleckstrin homology-like domain, family A, member 1 5.90 1.63 prostaglandin-endoperoxide synthase 2 26.84 6.09 protein kinase C, alpha 4.65 2.85 2C, magnesium-dependent, catalytic subunit 7.25 2.59 putative phosphate-phosphoenolpyruvate translocator 4.05 1.76 putative scaffolding protein POSH 3.36 1.69 putative small NID67 8.11 3.12 RAB20, member RAS oncogene family (predicted) 3.62 1.60 receptor (calcitonin) activity modifying protein 3 5.76 2.48 receptor (TNFRSF)-interacting serine-threonine kinase 2 (predicted) 6.34 2.28 receptor-interacting serine-threonine kinase 3 13.27 8.69 regulator of G-protein signaling 2 33.68 1.69 RNA polymerase 1-2 3.31 1.10 saccharomyces cerevisiae Nip7p homolog 3.03 1.51 semaphorin 4B (predicted) 8.12 2.35 Ser/Thr-like protein kinase lyk4 4.02 1.55 serine (or cysteine) proteinase inhibitor, clade B, member 2 437.35 35.98 serine (or cysteine) proteinase inhibitor, clade E, member 2 11.05 5.67 serum/glucocorticoid regulated kinase 23.80 2.82 sialyltransferase 1 5.55 0.99 stanniocalcin 1 3.24 1.18 Tenascin C 5.83 0.73 TERF1 (TRF1)-interacting nuclear factor 2 6.72 1.14 TGFB inducible early growth response 3.33 1.53 transducin-like enhancer of split 3, E(spl) homolog (Drosophila) 2.69 0.65 5.25 2.18 Transforming growth factor, beta receptor 1 2.69 1.19 transglutaminase 1 9.04 1.01 transmembrane 4 superfamily member 9 6.04 2.15 tribbles homolog 1 (Drosophila) 4.64 1.97 trinucleotide repeat containing 15 (predicted) 4.19 1.28 tumor necrosis factor, alpha-induced protein 2 (predicted) 6.41 2.40 twist gene homolog 1 (Drosophila) 3.42 1.49 twist homolog 2 (Drosophila) 5.49 1.80 UDP-N-acetylglucosamine pyrophosphorylase 1 (predicted) 16.12 6.80 v-jun sarcoma virus 17 oncogene homolog (avian) 5.42 3.21 WD repeat domain 3 (predicted) 2.32 1.04 zinc finger protein 36, C3H type-like 2 (predicted) 3.42 1.00 zinc finger, DHHC domain containing 13 (predicted) 2.72 1.11 Increased continuously over 12 hours 20 alpha-hydroxysteroid dehydrogenase 8.53 55.51 aldo-keto reductase family 1, member B8 18.62 36.27 branched chain aminotransferase 1, cytosolic 2.92 9.21 proteoglycan 2 3.12 17.75 ectonucleotide pyrophosphatase/ 1 5.08 8.12 EH-domain containing 4 3.48 5.20 endothelial cell-specific molecule 1 3.20 17.08 epithelial membrane protein 3 2.52 4.55 glucosaminyl (N-acetyl) transferase 1, core 2 15.45 17.87 , alpha 6 3.14 5.08 interleukin 1 receptor-like 1 14.49 29.46 isopentenyl-diphosphate delta isomerase 3.43 5.31 latent transforming growth factor beta binding protein 1 2.50 5.05 lectin, galactose binding, soluble 3 3.22 9.28 matrix metallopeptidase 24 4.46 16.41 microtubule-associated protein 1b 3.71 5.31 navigator 1 (predicted) 3.49 6.35 nidogen 2 (predicted) 2.56 5.99 Phosphofructokinase, 2.29 3.76 Plasminogen activator, urokinase 2.18 6.00 progressive ankylosis homolog (mouse) 13.45 17.35 protein C receptor, endothelial (predicted) 4.13 19.13 Rho GTPase activating protein 22 (predicted) 4.04 20.08 serine (or cysteine) proteinase inhibitor, clade E, member 1 2.80 4.49 solute carrier family 7 (cationic amino acid transporter, y+ system), 12.84 15.73 -member 8 squalene epoxidase 4.68 7.53 Increased to a plateau after 4 hours acetoacetyl-CoA synthetase 2.42 2.63 Adiponectin receptor 2 3.17 2.84 ATPase family, AAA domain containing 3A (predicted) 2.81 1.47 AXL receptor tyrosine kinase (predicted) 2.38 3.13 Basic helix-loop-helix domain containing, class B2 3.34 3.07 basic leucine zipper and W2 domains 2 2.64 3.70 B-cell CLL/lymphoma 10 2.84 2.15 block of proliferation 1 (predicted) 2.68 1.54 bradykinin receptor b2 4.32 4.03 brain protein 16 2.62 1.37 branched chain aminotransferase 1, cytosolic 5.05 3.65 brix domain containing 1 (predicted) 2.66 1.75 caspase 8 2.43 1.49 CD44 antigen 7.70 8.01 coagulation factor II (thrombin) receptor-like 1 2.67 1.58 Core promoter element binding protein 2.58 3.83 cytoplasmic linker 2 3.32 1.90 dual specificity phosphatase 14 (predicted) 2.34 1.55 dual specificity phosphatase 6 5.55 6.62 epidermal growth factor receptor pathway substrate 8 (predicted) 2.96 2.71 epithelial membrane protein 1 2.52 3.00 eukaryotic translation initiation factor 2B, subunit 3 gamma 2.89 2.10 fibroblast growth factor 2 5.32 3.95 GERp95 3.16 2.32 growth arrest specific 7 3.52 2.83 huntingtin interacting protein 1 2.97 1.86 hydroxysteroid (17-beta) dehydrogenase 7 4.65 5.81 Hypoxia induced gene 1 2.74 2.24 influenza virus NS1A binding protein (predicted) 2.84 1.59 interferon-related developmental regulator 1 3.74 3.87 karyopherin (importin) beta 3 (predicted) 4.20 3.54 lamin A 2.81 2.28 mesoderm development candidate 1 (predicted) 3.54 2.08 microtubule-associated protein 6 3.13 3.45 mitogen activated protein kinase kinase 3 (predicted) 2.67 1.27 mitogen-activated protein kinase 6 2.37 3.10 mitogen-activated protein kinase kinase kinase kinase 4 (predicted) 2.21 1.61 monocyte to macrophage differentiation-associated 5.11 5.70 myeloid cell leukemia sequence 1 2.67 2.49 natriuretic precursor type B 5.31 5.21 nestin 5.51 4.99 neural visinin-like Ca2+-binding protein type 3 2.50 2.23 nuclear RNA helicase, DECD variant of DEAD box family 2.61 3.55 nucleolar protein 1 (predicted) 3.15 1.73 nucleolar protein 5 2.26 1.85 nucleolar protein 5A (predicted) 2.36 1.70 opioid growth factor receptor-like 1 (predicted) 4.81 4.65 1 2.74 1.74 ornithine decarboxylase antizyme inhibitor 2.76 1.58 peroxisome proliferative activated receptor, 2.60 1.91 gamma, coactivator-related 1 phosphatidylserine receptor (predicted) 2.51 2.05 A2, group IVA (cytosolic, calcium-dependent) 4.43 3.49 Platelet derived growth factor, alpha 2.55 1.70 pleckstrin homology domain containing, family E, member 1 2.53 1.32 poliovirus receptor 10.07 8.60 Prickle-like 1 (Drosophila) 2.27 1.32 procollagen, type XV (predicted) 3.94 4.52 proliferation-associated 2G4, 38kDa 2.44 1.98 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 2.36 1.32 protein phosphatase 2A, regulatory subunit A (PR 65), beta isoform 3.11 1.99 protein tyrosine phosphatase, non-receptor type 1 2.77 1.96 protein tyrosine phosphatase, non-receptor type 12 2.65 1.62 pseudouridine synthase 1 (predicted) 2.82 1.71 purinergic receptor P2Y, G-protein coupled 2 3.83 3.19 putative regulation protein GS3 3.45 2.81 RAB11a, member RAS oncogene family 2.40 1.92 Ras association domain family 1 3.70 2.93 RAS p21 protein activator 1 3.85 5.00 RAS protein activator like 2 (predicted) 2.57 1.45 RIO kinase 2 2.19 1.17 runt related transcription factor 1 4.58 4.96 S-adenosylmethionine decarboxylase 1 2.90 1.64 schlafen 3 3.87 4.17 schwannomin interacting protein 1 (predicted) 3.54 2.06 solute carrier family 20 (phosphate transporter), member 1 7.41 6.56 spermidine/spermine N1-acetyl transferase 3.59 2.81 sterol O-acyltransferase 1 3.32 1.91 sterol-C4-methyl oxidase-like 3.72 3.53 syndecan 1 8.84 7.37 Taste receptor, type 1, member 2 4.20 3.24 tec protein tyrosine kinase 2.86 2.02 TG interacting factor (predicted) 3.02 1.70 thioredoxin reductase 1 2.69 1.81 THO complex 4 (predicted) 2.36 1.63 tight junction protein 2 2.62 1.27 tissue inhibitor of metalloproteinase 1 2.63 3.25 Transcription factor 8 (represses interleukin 2 expression) 2.47 1.31 transforming growth factor, beta 1 3.86 3.82 tripartite motif protein 47 (predicted) 3.58 3.50 tumor-associated protein 1 3.31 2.25 UDP-glucose ceramide glucosyltransferase 3.68 2.40 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 2.61 3.59 V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) 2.37 1.00 villin 2 3.77 2.58 v-ral simian leukemia viral oncogene homolog B 2.48 1.54 WD repeat domain 36 (predicted) 2.95 1.46 zinc finger protein 259 (predicted) 2.64 1.56 zinc finger protein 455 2.61 1.61 Did not change at 4 hours but increased at 12 hours 3-hydroxy-3-methylglutaryl-Coenzyme A reductase 1.51 2.94 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 1.17 3.22 Actinin, alpha 1 1.57 4.95 adenylyl cyclase 8 1.46 5.29 aldehyde dehydrogenase family 3, member A1 1.85 4.12 Alpha-mannosidase-like protein mRNA, 3' UTR 1.24 2.28 amphoterin induced gene and ORF 3 1.74 2.69 Arg/Abl-interacting protein ArgBP2 0.88 2.70 brain derived neurotrophic factor 0.47 2.95 calbindin 1 0.99 8.11 calcium channel, voltage-dependent, N type, alpha 1B subunit 1.38 2.71 calmodulin 1 1.08 2.35 capping protein (actin filament), gelsolin-like (predicted) 1.20 2.90 carbonic anhydrase 2 0.99 7.05 1.38 3.10 Cbp/p300-interacting transactivator with Glu 1.17 4.08 /Asp-rich carboxy-terminal domain 1 Cdc42 guanine nucleotide exchange factor (GEF) 9 1.68 5.08 chloride intracellular channel 1 1.46 2.38 cofilin 1 /// similar to Rbm6 protein 1.70 2.48 cold shock domain protein A 1.46 2.47 core promoter element binding protein 1.82 3.27 cytochrome c, somatic 1.36 2.41 Death-associated protein 1.69 2.72 developmentally regulated protein TPO1 1.36 3.48 early growth response 1 1.50 2.34 ELOVL family member 6, elongation of long chain fatty acids (yeast) 1.24 2.41 1, alpha 1.30 2.81 expressed in non-metastatic cells 1 1.32 2.94 farensyl diphosphate synthase 1.54 3.34 farnesyl diphosphate farnesyl transferase 1 0.80 2.45 Fc receptor, IgG, low affinity III 1.20 12.72 fibrillarin (predicted) 1.96 2.37 fibrillin 2 0.94 2.75 FK506-binding protein 1a 1.30 2.72 galactose-4-epimerase, UDP 1.12 3.29 gap junction membrane channel protein alpha 4 1.43 2.88 glial cell line derived neurotrophic factor family receptor alpha 1 1.28 3.31 growth associated protein 43 1.09 16.19 GTP cyclohydrolase I feedback regulator 1.03 3.31 hairy and enhancer of split 1 (Drosophila) 1.05 4.16 binding protein (predicted) 1.76 2.41 interleukin 1 receptor accessory protein 1.73 5.98 A 1.66 3.50 lectin, galactose binding, soluble 1 1.32 3.28 lysyl oxidase-like 2 (predicted) 1.16 2.55 matrix metallopeptidase 3 1.17 3.40 matrix metalloproteinase 16 1.79 3.71 mitogen activated protein kinase kinase 1 1.73 2.28 moesin 1.63 3.66 myosin Ib 1.63 2.46 NAD(P) dependent steroid dehydrogenase-like 1.32 2.98 NADPH oxidase 1 1.66 5.65 nesprin-1 0.75 6.27 neuritin 0.96 2.88 neuronal guanine nucleotide exchange factor 1.51 9.14 neuronal pentraxin receptor 1.70 4.18 nucleolar protein family A, member 2 (predicted) 1.38 2.68 olfactomedin 1 1.13 3.73 PDGFA associated protein 1 1.68 2.71 PDZ and LIM domain 1 1.09 4.02 peripherin 1 1.41 3.04 Phosphatidylinositol 4-kinase type-II beta 1.92 3.59 , delta 4 0.94 4.95 phytanoyl-CoA dioxygenase domain containing 1 (predicted) 1.06 2.70 prepro-Neuropeptide W polypeptide 1.74 2.51 prostaglandin I2 (prostacyclin) synthase 1.57 2.36 Protein tyrosine phosphatase, receptor type, M 0.91 3.25 protein tyrosine phosphatase, receptor type, N 1.85 13.12 proteolipid protein 2 1.44 2.75 putative ISG12(b) protein 0.82 4.80 pyrophosphatase 1.47 2.69 pyrroline-5-carboxylate synthetase 1.02 2.44 -(glutamate gamma-semialdehyde synthetase) (predicted) rhoB gene 1.52 3.11 ribosome binding protein 1 homolog 180kDa (dog) (predicted) 1.78 5.47 S100 calcium-binding protein A4 1.55 4.08 SAR1a gene homolog 1 1.16 2.68 scavenger receptor class B, member 1 1.30 2.49 secreted frizzled-related protein 4 1.67 3.77 secreted phosphoprotein 1 1.43 10.41 serine hydroxymethyl transferase 2 (mitochondrial) (predicted) 1.62 2.46 Serine/threonine kinase 2 1.89 2.72 SH3-domain kinase binding protein 1 1.14 3.26 solute carrier family 17 0.77 4.95 surfeit gene 4 (predicted) 0.97 2.36 1 1.03 5.73 transmembrane protein AMIGO2 0.76 2.33 trophoblast 1.84 4.03 tropomyosin 3, gamma /// tropomyosin isoform 6 1.33 2.61 tumor necrosis factor receptor superfamily, 1.67 4.43 -member 11b (osteoprotegerin) Vacuole Membrane Protein 1 1.41 2.43 Down-regulated by EGFR activation Decreased at 4 hours but returned towards control values at 12 hours Control/EGF4h Control/EGF12h A kinase (PRKA) anchor protein 5 -4.76 -2.10 Ab1-152 -14.56 -5.71 ankyrin repeat domain 1 (cardiac muscle) -3.75 -0.61 calcitonin receptor-like -3.83 -0.99 dual specificity phosphatase 1 -3.17 -1.08 endothelin 1 -3.16 0.81 growth differentiation factor 6 -3.25 -0.97 H1 histone family, member 0 -2.77 -1.06 high mobility group box transcription factor 1 -3.94 -1.64 Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -3.17 1.20 Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -3.30 -0.86 kinesin-like 8 (predicted) -3.89 -2.26 Kruppel-like factor 15 -22.16 -15.74 LIM and cysteine-rich domains 1 (predicted) -9.06 -0.98 LIM domain only 4 (predicted) -4.50 -2.23 MAD homolog 6 (Drosophila) (predicted) -3.68 -1.99 mesenchyme homeo box 2 -15.87 -1.36 natriuretic peptide precursor type C -6.72 -2.11 protein tyrosine phosphatase 2E -3.23 -1.54 response gene to complement 32 -4.61 -2.42 Rho GTPase activating protein 24 (predicted) -2.93 -1.27 solute carrier family 39 (iron-regulated transporter), member 1 -12.15 -1.58 Tropomyosin 1, alpha -9.88 -4.67 upregulated by 1,25-dihydroxyvitamin D-3 -9.88 -2.13 V-fos FBJ murine osteosarcoma viral oncogene homolog -5.01 1.50 zinc binding alcohol dehydrogenase, domain containing 2 (predicted) -2.99 -1.30 zinc finger, FYVE domain containing 21 (predicted) -3.61 -1.50 Decreased continuously over 12 hours 3-alpha-hydroxysteroid dehydrogenase -2.72 -8.54 angiopoietin 2 -2.63 -33.81 basic helix-loop-helix domain containing, class B3 -3.88 -5.60 chemokine orphan receptor 1 -2.26 -5.89 cytochrome P450, family 26, subfamily b, polypeptide 1 -4.28 -7.53 dehydrogenase/reductase (SDR family) member 3 (predicted) -12.37 -26.55 Down syndrome critical region gene 1-like 1 -2.40 -13.15 flavin containing monooxygenase 3 -5.63 -9.03 guanylate cyclase 1, soluble, alpha 3 -3.42 -4.99 Neurotrophic tyrosine kinase, receptor, type 3 -2.46 -9.81 Rho GTPase activating protein 18 (predicted) -3.28 -6.95 Decreased to a plateau after 4 hours adrenomedullin -2.90 -2.66 amyloid beta (A4) precursor protein-binding, family B, member 1 -2.83 -1.91 angiotensin II receptor, type 1 (AT1A) -3.51 -3.06 ATPase, Na+/K+ transporting, beta 3 polypeptide -4.10 -3.07 bone morphogenetic protein 3 -3.20 -4.18 bone morphogenetic protein 4 -3.02 -2.76 caspase 11 -2.56 -2.90 CDC42 effector protein (Rho GTPase binding) 3 (predicted) -3.65 -3.36 Cobl-like 1 (predicted) -2.29 -2.14 D site albumin promoter binding protein -3.87 -4.76 delta sleep inducing peptide, immunoreactor -2.52 -1.67 fibroblast growth factor receptor 2 -2.47 -2.01 fibroblast growth factor receptor 3 -2.35 -2.16 flavin containing monooxygenase 4 -4.10 -2.77 frizzled homolog 2 (Drosophila) -4.06 -2.81 glutamate-cysteine ligase, catalytic subunit -2.75 -1.81 glypican 2 (cerebroglycan) -2.30 -2.42 growth arrest and DNA-damage-inducible 45 alpha -2.55 -1.25 growth arrest and DNA-damage-inducible 45 beta (predicted) -3.54 -3.12 guanylate cyclase 1, soluble, beta 3 -2.93 -2.87 histone 3, H2a (predicted) -2.82 -1.43 homocysteine-, endoplasmic reticulum stress-inducible, -2.65 -1.76 interferon inducible protein 1 (predicted) -2.56 -1.95 interferon regulatory factor 1 -2.77 -1.39 interferon-induced protein 44 (predicted) -2.41 -3.67 Jun dimerization protein 2 -3.46 -2.10 K-Cl cotransporter KCC4 -2.81 -2.96 latrophilin 2 -2.81 -1.37 LIM and senescent cell antigen like domains 2 (predicted) -2.79 -1.64 Low Mr GTP-binding protein -2.30 -2.03 membrane-associated guanylate kinase-related (MAGI-3) -2.88 -3.05 midline 1 -2.67 -1.26 N-acetyltransferase 1 (arylamine N-acetyltransferase) -2.71 -1.45 neural precursor cell expressed, -3.35 -3.23 -developmentally down-regulated gene 9 (predicted) nexilin -3.09 -1.65 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -2.75 -3.22 oxidation resistance 1 -2.57 -2.78 PDZ and LIM domain 2 -2.31 -2.00 phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 -3.04 -2.70 phosphodiesterase 4B -3.28 -2.54 -2.24 -1.72 propionyl-coenzyme A carboxylase, alpha polypeptide -2.83 -1.63 Ras homolog gene family, member E -2.42 -2.00 Retinoblastoma 1 -2.12 -2.29 RNA binding motif protein 16 -2.69 -1.82 Serine/threonine kinase 17b (apoptosis-inducing) -2.35 -1.50 thymopoietin -2.78 -2.06 titin immunoglobulin domain protein (myotilin) (predicted) -6.78 -5.51 transcription factor 4 -2.52 -1.63 transcription factor AP-2 beta (predicted) -2.67 -1.31 transforming growth factor beta 1 induced transcript 4 -2.48 -2.23 tumor suppressor candidate 4 (predicted) -3.40 -2.19 ubiquitin-like domain member 1 -2.54 -1.36 vascular cell adhesion molecule 1 -3.42 -4.22 very low density lipoprotein receptor -2.77 -2.26 WD repeat domain 6 (predicted) -3.14 -2.31 xeroderma pigmentosum, complementation group A (predicted) -3.00 -2.39 Did not change at 4 hours but decreased at 12 hours 130kDa-Ins(1,4,5)P3 binding protein -0.83 -3.24 5-oxoprolinase (ATP-hydrolysing) -1.64 -4.11 Acyl-Coenzyme A dehydrogenase, short/branched chain -1.34 -2.96 Adenylate cyclase 5 -1.40 -2.60 adrenergic receptor, beta 2 -1.81 -5.61 alcohol dehydrogenase 1 -1.22 -4.47 aldehyde dehydrogenase family 6, subfamily A1 -1.79 -3.01 aldehyde oxidase 1 -1.28 -8.93 aldolase C, fructose-biphosphate -1.26 -7.99 amine oxidase, copper containing 3 -1.47 -4.58 Angiomotin like 2 -1.70 -2.77 Angiopoietin-like 2 -1.94 -2.81 angiopoietin-like protein 4 -1.13 -6.06 antigen identified by monoclonal antibody MRC OX-2 -1.46 -2.48 aquaporin 1 -0.96 -5.90 ATP-binding cassette, sub-family A (ABC1), member 2 -1.48 -3.62 brain glycogen phosphorylase -1.55 -2.29 branched chain aminotransferase 2, mitochondrial -1.53 -2.29 cadherin 1 -1.17 -4.15 cadherin EGF LAG seven-pass G-type receptor 2 -1.60 -3.10 cadherin-related neuronal receptor 11 -1.25 -2.90 carbonic anhydrase-related XI protein -1.61 -2.83 catenin alpha-like 1 (predicted) -0.72 -2.61 cathepsin F (predicted) -1.23 -3.82 centromere protein J (predicted) -1.48 -2.64 ceroid-lipofuscinosis, neuronal 6 (predicted) -1.75 -5.49 ceruloplasmin -1.30 -2.35 chemokine (C-X-C motif) ligand 12 -1.60 -5.52 Chimerin (chimaerin) 2 -1.52 -3.27 chloride intracellular channel 3 (predicted) -1.91 -15.48 citrate beta like (predicted) -1.24 -3.30 Claudin 11 -1.46 -31.19 collectin sub-family member 12 -1.42 -2.40 complement component 1, q subcomponent-like 3 (predicted) -1.56 -2.98 complement component factor h -1.20 -2.23 creatine kinase, mitochondrial 1, ubiquitous -1.33 -9.30 crystallin, lamda 1 -1.39 -8.35 CUG triplet repeat,RNA-binding protein 2 -1.23 -2.68 cysteine and glycine-rich protein 2 -0.98 -3.08 cysteine-rich motor neuron 1 (predicted) -1.34 -2.35 Cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase) -1.29 -5.65 cytochrome P450-like protein -1.64 -2.36 cytosolic cysteine dioxygenase 1 -1.77 -10.18 decorin -1.44 -6.22 dehydrogenase/reductase (SDR family) member 6 (predicted) -1.67 -6.82 dehydrogenase/reductase (SDR family) member 8 -1.58 -2.27 dickkopf homolog 3 (Xenopus laevis) -1.26 -2.44 disabled homolog 2 (Drosophila) -1.45 -3.59 discoidin domain receptor family, member 1 -1.49 -2.42 dynein, cytoplasmic, intermediate chain 1 -1.60 -5.12 Eph receptor B1 -1.91 -2.74 epithelial membrane protein 2 -1.41 -3.51 epoxide 1 -1.50 -4.54 epoxide hydrolase 2, cytoplasmic -1.31 -4.11 ER transmembrane protein Dri 42 -0.94 -3.93 etoile, Sam68-like protein SLM-2 -1.47 -3.86 extracellular matrix protein 2, female organ and adipocyte specific -1.27 -7.50 fibromodulin -1.23 -3.79 forkhead box O1A -1.92 -2.48 Four and a half LIM domains 1 -1.49 -3.21 frizzled homolog 1 (Drosophila) -1.10 -2.47 F-spondin -1.58 -4.55 fucosidase, alpha-L- 2, plasma -1.37 -3.48 fumarylacetoacetate hydrolase -1.25 -3.01 gap junction membrane channel protein beta 2 -0.91 -5.34 gap junction membrane channel protein beta 6 -0.87 -17.43 glial cell line derived neurotrophic factor family receptor alpha 2 -1.49 -4.20 glucosidase, alpha; acid (Pompe disease, -1.14 -2.90 -glycogen storage disease type II) glutathione S-transferase A5 -1.28 -2.42 glutathione S-transferase theta 1 -1.34 -2.77 glutathione S-transferase, theta 2 -1.86 -3.00 glypican 1 -1.15 -3.10 G-protein signalling modulator 1 (AGS3-like, C. elegans) -1.88 -2.45 growth arrest specific 6 -1.23 -4.47 Guanine nucleotide exchange factor (Mrgef) -1.22 -40.07 hexosaminidase B (predicted) -1.65 -3.79 Hypothetical LOC300074 -1.14 -3.82 Hypothetical protein FLJ13158 -1.20 -2.55 Immediate early response 3 -1.31 -8.71 Insulin-like growth factor I mRNA, 3' end of mRNA -1.65 -3.01 interleukin 11 receptor, alpha chain 1 -1.44 -2.26 interleukin 13 receptor, alpha 2 -1.14 -4.10 isovaleryl coenzyme A dehydrogenase -1.81 -2.68 kelch-like 7 (Drosophila) (predicted) -1.95 -2.51 KIAA1536 protein -1.96 -3.02 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain -1.74 -3.01 lactate dehydrogenase B -1.78 -4.40 laminin, beta 2 -1.11 -2.93 LIM motif-containing protein kinase 2 -1.55 -2.27 lipoprotein -1.32 -4.58 low density lipoprotein receptor-related protein associated protein 1 -1.26 -2.66 Mal, T-cell differentiation protein 2 -1.28 -4.43 mannan-binding lectin serine peptidase 1 -1.86 -3.26 microfibrillar associated protein 5 (predicted) -1.23 -3.19 microtubule-actin crosslinking factor 1 (predicted) -1.79 -2.53 Monoglyceride lipase -1.27 -3.07 mucolipin 1 (predicted) -1.83 -2.66 natriuretic peptide receptor 3 -1.70 -6.80 nephroblastoma overexpressed gene -1.52 -4.82 neural precursor cell expressed, developmentally down-regulated 4-like -0.59 -2.58 neurexin 1 -1.37 -7.44 2 -1.76 -3.20 nicotinate phosphoribosyltransferase-like protein -1.33 -2.95 N-myc downstream regulated gene 1 (predicted) -1.17 -2.33 non-metastatic cells 3, protein expressed in -1.63 -4.11 NTF2-related export protein 1 (predicted) -0.63 -2.41 Origin recognition complex, subunit 4 -1.42 -2.46 osteomodulin -1.82 -11.30 Osteotesticular phosphatase -1.16 -2.84 palmitoyl-protein -1.32 -2.34 pannexin 3 -1.75 -2.88 parvin, alpha -1.32 -4.96 PDZ and LIM domain 3 -1.71 -3.93 period homolog 2 (Drosophila) -0.57 -3.51 peroxisomal trans-2-enoyl-CoA reductase -1.45 -2.82 Phosphatase and actin regulator 2 -1.72 -2.49 phosphatidylinositol glycan, class S -1.38 -2.15 , group VI -1.32 -2.52 polycystic kidney and hepatic disease 1-like 1 (predicted) -1.46 -6.16 pre-B-cell colony enhancing factor 1 -0.59 -2.35 pregnancy-induced growth inhibitor -0.92 -2.49 procollagen, type XI, alpha 1 -1.52 -3.37 proprotein convertase subtilisin/kexin type 5 -1.26 -4.19 protease, serine, 23 -1.01 -2.91 protein kinase, lysine deficient 4 -0.72 -2.86 , regulatory (inhibitor) subunit 14c -1.24 -3.16 protein phosphatase 1, regulatory (inhibitor) subunit 3B -1.36 -5.55 protein regulator of cytokinesis 1 (predicted) -1.17 -2.59 protein tyrosine phosphatase, receptor-type, -1.63 -2.26 -F interacting protein, binding protein 2 proteolipid protein -1.61 -8.15 PTEN induced putative kinase 1 (predicted) -1.42 -2.97 Putative chloride channel (similar to Mm Clcn4-2) -1.38 -2.92 Rab40b, member RAS oncogene family (predicted) -1.88 -2.45 RAD52 homolog B (S. cerevisiae) (predicted) -1.34 -2.88 rapostlin -1.56 -2.34 Ras-related GTP-binding protein Rab29 -1.60 -2.48 retinoic acid induced 14 (predicted) -1.45 -2.52 selenium binding protein 2 -1.74 -5.38 selenoprotein P, plasma, 1 -1.36 -6.99 sema domain, immunoglobulin domain (Ig), short basic domain, -1.12 -3.37 -secreted, (semaphorin) 3B Sequestosome 1 -1.86 -2.49 serum deprivation response protein -1.78 -3.05 SH3 domain and tetratricopeptide repeats 1 (predicted) -1.09 -3.20 sine oculis-related homeobox 5 homolog (Drosophila) (predicted) -1.45 -3.05 solute carrier family 2 (facilitated glucose transporter), member 13 -1.24 -3.22 solute carrier family 27 (fatty acid transporter), member 3 (predicted) -1.91 -4.37 Solute carrier family 35, member B2 -0.81 -2.26 solute carrier family 4, member 4 -1.36 -4.52 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 -1.71 -12.45 SPARC-related modular calcium binding protein 1 -1.23 -4.26 sperm associated antigen 5 -1.17 -2.98 spinal cord expression protein 4 -1.44 -3.41 stathmin 1 -1.54 -2.92 Sulfatase 1 -0.97 -2.90 family 1A, phenol-preferring, member 1 -1.91 -47.52 sushi domain containing 2 (predicted) -1.26 -2.87 syndecan 2 -1.26 -2.40 testis specific, 10 -1.97 -24.82 -1.36 -7.43 thyroid hormone receptor alpha -1.42 -3.75 Thyroid hormone-response protein-1 -1.95 -4.25 pathway inhibitor -1.46 -2.24 transducin-like enhancer of split 2, homolog of Drosophila E(spl) -1.40 -2.88 transforming growth factor beta 1 induced transcript 1 -1.77 -0.44 Transforming growth factor, beta 2 -1.84 -3.78 transmembrane 4 superfamily member 1 (predicted) -1.34 -2.81 transmembrane 4 superfamily member 4 -1.88 -3.11 transmembrane protein 14A (predicted) -1.69 -2.42 troponin T2, cardiac -1.16 -2.63 tumor necrosis factor (ligand) superfamily, member 13 (predicted) -1.01 -3.88 UDP-N-acetyl-alpha-D-galactosamine: -1.13 -3.63 -polypeptide N-acetylgalactosaminyltransferase 14 (predicted) UNC-119 homolog (C. elegans) -1.32 -2.78 unc-5 homolog C (C. elegans) -1.28 -2.59 vanin 1 (predicted) -1.44 -3.72 WAP four-disulfide core domain 1 -1.33 -3.22 WNT1 inducible signaling pathway protein 2 -1.61 -5.07 WW domain binding protein 1 (predicted) -1.65 -2.20 xanthine dehydrogenase -1.73 -2.43 zinc-fingers and homeoboxes 1 -1.95 -2.44