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Table S3: List of EGFR Pathway-Regulated Genes. Gene Name Fold Fold

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Table S3: List of EGFR Pathway-Regulated Genes. Gene Name Fold Fold Table S3: List of EGFR pathway-regulated genes. Gene Name Fold Fold EGF4h/Control EGF12h/Control Up-regulated by EGFR activation Increased at 4 hours but declined at 12 hours A kinase (PRKA) anchor protein (gravin) 12 7.67 1.58 Ab2-427 3.05 0.99 acyl-CoA synthetase long-chain family member 1 3.88 0.94 acyl-CoA synthetase long-chain family member 4 6.25 3.58 adipose differentiation-related protein 5.46 3.51 Aldehyde dehydrogenase family 1, subfamily A3 38.45 1.78 amphiregulin 77.79 27.77 arginase 1 4.10 2.06 arginosuccinate synthetase 3.00 1.19 aryl hydrocarbon receptor 5.03 1.55 ATPase, Ca++ transporting, plasma membrane 1 4.08 2.31 basic helix-loop-helix domain containing, class B2 7.86 4.12 Basophilic leukemia expressed sequence 06 (Bles06) 2.89 1.17 BH3 interacting domain death agonist 3.09 1.17 brain-specific angiogenesis inhibitor 1-associated protein 2 7.73 2.80 breast cancer anti-estrogen resistance 3 (predicted) 3.71 1.85 bridging integrator 1 6.07 2.08 cellular retinoic acid binding protein 2 2.47 1.11 charged amino acid rich leucine zipper 1 (predicted) 2.22 1.25 chemokine (C-C motif) ligand 2 3.29 1.34 chemokine (C-C motif) ligand 20 5.91 0.98 Chemotactic protein-3 3.82 -2.1 cryptochrome 1 (photolyase-like) 2.99 0.51 cyclin H 2.26 1.34 cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 3.25 1.25 cysteine knot superfamily 1, BMP antagonist 1 20.20 3.28 cytokine receptor-like factor 1 (predicted) 5.43 1.23 death-associated kinase 2 (predicted) 5.03 3.07 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (predicted) 2.46 1.38 decay accelarating factor 1 5.85 2.82 dehydrogenase/reductase (SDR family) member 9 3.22 1.13 diphtheria toxin receptor 9.99 5.16 dual specificity phosphatase 5 29.54 12.07 early growth response 2 7.99 2.54 endothelial differentiation sphingolipid G-protein-coupled receptor 1 6.05 1.05 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 3.03 1.36 endothelin receptor type A 2.59 0.57 eukaryotic translation initiation factor 4E 2.41 1.29 FK506 binding protein 5 (predicted) 10.11 3.03 FMS-like tyrosine kinase 1 3.74 1.51 follistatin 10.82 6.51 forkhead box P1 (predicted) 2.83 1.27 fos-like antigen 1 41.47 8.70 glutamate-rich WD repeat containing 1 (predicted) 2.59 1.07 glutaredoxin 1 (thioltransferase) 4.13 2.08 Guanosine monophosphate reductase 2 3.09 1.12 heat shock protein 2 2.85 0.50 hexokinase 2 20.80 1.69 high mobility group AT-hook 1 6.40 4.28 homer homolog 1 (Drosophila) 2.35 1.36 hormone-regulated proliferation-associated 20 kDa protein 3.00 1.20 hyaluronan synthase 2 8.46 3.38 IBR domain containing 3 (predicted) 2.57 1.15 keratinocytes proline-rich protein 5.03 3.20 kinesin family member C3 (predicted) 4.60 2.35 leucine-rich repeat-containing 5 (predicted) 2.69 1.05 leukemia inhibitory factor 2.33 1.30 linker of T-cell receptor pathways 6.74 2.70 Ly1 antibody reactive clone (predicted) 3.47 1.92 lysosomal trafficking regulator 5.22 1.41 met proto-oncogene 3.61 1.64 methionine adenosyltransferase II, alpha 2.41 1.07 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) 2.86 1.11 myelocytomatosis viral oncogene homolog (avian) 4.56 2.69 myeloid cell nuclear differentiation antigen (predicted) 27.09 12.32 myosin IE 5.16 2.54 myosin IG (predicted) 4.94 3.25 myeloid differentiation primary response gene 116 2.68 1.31 nerve growth factor, beta 7.88 1.66 Notch gene homolog 1, (Drosophila) 3.41 1.21 Notch-regulated ankyrin repeat protein (predicted) 4.47 1.17 nucleolar and coiled-body phosphoprotein 1 2.62 1.34 Nucleoporin like 1 3.98 1.96 oxidized low density lipoprotein (lectin-like) receptor 1 10.30 1.52 peptidylprolyl isomerase F (cyclophilin F) 2.66 0.94 Phosphoribosyl pyrophosphate amidotransferase 3.45 1.39 plasminogen activator, urokinase receptor 21.00 7.15 pleckstrin homology, Sec7 and coiled-coil domains 3 8.18 1.91 pleckstrin homology-like domain, family A, member 1 5.90 1.63 prostaglandin-endoperoxide synthase 2 26.84 6.09 protein kinase C, alpha 4.65 2.85 protein phosphatase 2C, magnesium-dependent, catalytic subunit 7.25 2.59 putative phosphate-phosphoenolpyruvate translocator 4.05 1.76 putative scaffolding protein POSH 3.36 1.69 putative small membrane protein NID67 8.11 3.12 RAB20, member RAS oncogene family (predicted) 3.62 1.60 receptor (calcitonin) activity modifying protein 3 5.76 2.48 receptor (TNFRSF)-interacting serine-threonine kinase 2 (predicted) 6.34 2.28 receptor-interacting serine-threonine kinase 3 13.27 8.69 regulator of G-protein signaling 2 33.68 1.69 RNA polymerase 1-2 3.31 1.10 saccharomyces cerevisiae Nip7p homolog 3.03 1.51 semaphorin 4B (predicted) 8.12 2.35 Ser/Thr-like protein kinase lyk4 4.02 1.55 serine (or cysteine) proteinase inhibitor, clade B, member 2 437.35 35.98 serine (or cysteine) proteinase inhibitor, clade E, member 2 11.05 5.67 serum/glucocorticoid regulated kinase 23.80 2.82 sialyltransferase 1 5.55 0.99 stanniocalcin 1 3.24 1.18 Tenascin C 5.83 0.73 TERF1 (TRF1)-interacting nuclear factor 2 6.72 1.14 TGFB inducible early growth response 3.33 1.53 transducin-like enhancer of split 3, E(spl) homolog (Drosophila) 2.69 0.65 Transferrin receptor 5.25 2.18 Transforming growth factor, beta receptor 1 2.69 1.19 transglutaminase 1 9.04 1.01 transmembrane 4 superfamily member 9 6.04 2.15 tribbles homolog 1 (Drosophila) 4.64 1.97 trinucleotide repeat containing 15 (predicted) 4.19 1.28 tumor necrosis factor, alpha-induced protein 2 (predicted) 6.41 2.40 twist gene homolog 1 (Drosophila) 3.42 1.49 twist homolog 2 (Drosophila) 5.49 1.80 UDP-N-acetylglucosamine pyrophosphorylase 1 (predicted) 16.12 6.80 v-jun sarcoma virus 17 oncogene homolog (avian) 5.42 3.21 WD repeat domain 3 (predicted) 2.32 1.04 zinc finger protein 36, C3H type-like 2 (predicted) 3.42 1.00 zinc finger, DHHC domain containing 13 (predicted) 2.72 1.11 Increased continuously over 12 hours 20 alpha-hydroxysteroid dehydrogenase 8.53 55.51 aldo-keto reductase family 1, member B8 18.62 36.27 branched chain aminotransferase 1, cytosolic 2.92 9.21 chondroitin sulfate proteoglycan 2 3.12 17.75 ectonucleotide pyrophosphatase/phosphodiesterase 1 5.08 8.12 EH-domain containing 4 3.48 5.20 endothelial cell-specific molecule 1 3.20 17.08 epithelial membrane protein 3 2.52 4.55 glucosaminyl (N-acetyl) transferase 1, core 2 15.45 17.87 Integrin, alpha 6 3.14 5.08 interleukin 1 receptor-like 1 14.49 29.46 isopentenyl-diphosphate delta isomerase 3.43 5.31 latent transforming growth factor beta binding protein 1 2.50 5.05 lectin, galactose binding, soluble 3 3.22 9.28 matrix metallopeptidase 24 4.46 16.41 microtubule-associated protein 1b 3.71 5.31 neuron navigator 1 (predicted) 3.49 6.35 nidogen 2 (predicted) 2.56 5.99 Phosphofructokinase, platelet 2.29 3.76 Plasminogen activator, urokinase 2.18 6.00 progressive ankylosis homolog (mouse) 13.45 17.35 protein C receptor, endothelial (predicted) 4.13 19.13 Rho GTPase activating protein 22 (predicted) 4.04 20.08 serine (or cysteine) proteinase inhibitor, clade E, member 1 2.80 4.49 solute carrier family 7 (cationic amino acid transporter, y+ system), 12.84 15.73 -member 8 squalene epoxidase 4.68 7.53 Increased to a plateau after 4 hours acetoacetyl-CoA synthetase 2.42 2.63 Adiponectin receptor 2 3.17 2.84 ATPase family, AAA domain containing 3A (predicted) 2.81 1.47 AXL receptor tyrosine kinase (predicted) 2.38 3.13 Basic helix-loop-helix domain containing, class B2 3.34 3.07 basic leucine zipper and W2 domains 2 2.64 3.70 B-cell CLL/lymphoma 10 2.84 2.15 block of proliferation 1 (predicted) 2.68 1.54 bradykinin receptor b2 4.32 4.03 brain protein 16 2.62 1.37 branched chain aminotransferase 1, cytosolic 5.05 3.65 brix domain containing 1 (predicted) 2.66 1.75 caspase 8 2.43 1.49 CD44 antigen 7.70 8.01 coagulation factor II (thrombin) receptor-like 1 2.67 1.58 Core promoter element binding protein 2.58 3.83 cytoplasmic linker 2 3.32 1.90 dual specificity phosphatase 14 (predicted) 2.34 1.55 dual specificity phosphatase 6 5.55 6.62 epidermal growth factor receptor pathway substrate 8 (predicted) 2.96 2.71 epithelial membrane protein 1 2.52 3.00 eukaryotic translation initiation factor 2B, subunit 3 gamma 2.89 2.10 fibroblast growth factor 2 5.32 3.95 GERp95 3.16 2.32 growth arrest specific 7 3.52 2.83 huntingtin interacting protein 1 2.97 1.86 hydroxysteroid (17-beta) dehydrogenase 7 4.65 5.81 Hypoxia induced gene 1 2.74 2.24 influenza virus NS1A binding protein (predicted) 2.84 1.59 interferon-related developmental regulator 1 3.74 3.87 karyopherin (importin) beta 3 (predicted) 4.20 3.54 lamin A 2.81 2.28 mesoderm development candidate 1 (predicted) 3.54 2.08 microtubule-associated protein 6 3.13 3.45 mitogen activated protein kinase kinase 3 (predicted) 2.67 1.27 mitogen-activated protein kinase 6 2.37 3.10 mitogen-activated protein kinase kinase kinase kinase 4 (predicted) 2.21 1.61 monocyte to macrophage differentiation-associated 5.11 5.70 myeloid cell leukemia sequence 1 2.67 2.49 natriuretic peptide precursor type B 5.31 5.21 nestin 5.51 4.99 neural visinin-like Ca2+-binding protein type 3 2.50 2.23 nuclear RNA helicase, DECD variant of DEAD box family 2.61 3.55 nucleolar protein 1 (predicted) 3.15 1.73 nucleolar protein 5 2.26 1.85 nucleolar protein 5A (predicted) 2.36 1.70 opioid growth factor receptor-like 1 (predicted) 4.81 4.65 ornithine decarboxylase 1 2.74 1.74 ornithine decarboxylase antizyme inhibitor 2.76 1.58 peroxisome proliferative activated receptor, 2.60 1.91 gamma, coactivator-related 1 phosphatidylserine receptor (predicted) 2.51 2.05 phospholipase A2, group IVA (cytosolic, calcium-dependent) 4.43
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