Supplementary Table 1. Differentially Expressed following 30 and 90 minutes CRAL 30 min. 90 min. Ischemia Ischemia Vs Sham Vs Sham Accession Name Symbol 3 h 12 h 3 h 12 h NM_024486 Activin A receptor, type 1 Acvr1 1.86 Z48444 A disintegrin and metalloprotease domain 10 Adam10 1.76 BE118251 Activated leukocyte molecule Alcam 0.66 2.20 NM_031351 Attractin Atrn 2.47 BF282223 Lymphocyte antigen 68 C1qr1 8.04 NM_017338 Calcitonin/calcitonin-related polypeptide, alpha Calca 2.04 AA859556 beta Catnb 2.00 NM_031530 Chemokine (C-C motif) ligand 2 Ccl2 4.73 NM_012924 CD44 antigen Cd44 4.89 9.12 NM_031333 2 Cdh2 1.92 AB011529 Cadherin EGF LAG seven-pass G-type receptor 2 Celsr2 1.78

NM_031320 Cadherin EGF LAG seven-pass G-type receptor 3 Celsr3 0.73 BE109018 Contactin 1 Cntn1 0.72 0.58 NM_053879 Contactin 4 Cntn4 1.72 AW142047 Procollagen, type XI, alpha 1 Col11a1 1.53 Z78279 , type 1, alpha 1 Col1a1 1.72 NM_012929 Procollagen, type II, alpha 1 Col2a1 1.65 AI172281 Collagen, type V, alpha 2 Col5a2 0.34 AF062402 Chondroitin sulfate 2 Cspg2 2.21 NM_022266 Connective tissue growth factor Ctgf 0.55 0.36 NM_030845 Chemokine (C-X-C motif) ligand 1 Cxcl1 1.45 8.84 U22520 Chemokine (C-X-C motif) ligand 10 Cxcl10 2.80 NM_022177 Chemokine (C-X-C motif) ligand 12 Cxcl12 0.41 NM_053647 Chemokine (C-X-C motif) ligand 2 Cxcl2 1.85 AI170387 Chemokine (C-X-C motif) ligand 9 Cxcl9 0.57 NM_013137 Discoidin domain receptor family, member 1 Ddr1 1.80 AI234173 Coagulation factor VIII F8 0.63 NM_012967 Intercellular adhesion molecule 1 Icam1 7.99 NM_031512 Interleukin 1 beta Il1b 2.97 4.45 3.90 NM_017022 beta 1 Itgb1 2.92 4.66 NM_031520 heavy chain 10, non-muscle Myh10 2.16 NM_031521 Neural 1 Ncam1 4.76 1.79 NM_021682 Neuronal growth regulator 1 Negr1 5.54 2.23 U77697 Platelet/endothelial cell adhesion molecule Pecam 2.57 U76717 PG10.2 Pg10.2 5.87 4.14 NM_019140 Protein tyrosine , receptor type, D Ptprd 1.78 AF091111 Poliovirus receptor-related 1 Pvrl1 2.06 NM_031831 Reticulon 4 Rtn4 1.95 NM_017221 Sonic hedgehog homolog (Drosophila) Shh 1.98 NM_022632 Slit2 2.73 X89963 Thrombospondin 4 Thbs4 0.35 0.30 NM_012889 Vascular cell adhesion molecule 1 Vcam1 1.51

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_019156 Vtn 0.41 0.41 NM_031716 WNT1 inducible signaling pathway protein 1 Wisp1 0.28 AI411352 membrane channel protein alpha 1 Gja1 1.96 0.47 NM_053388 Gap junction membrane channel protein beta 6 Gjb6 1.49 NM_019147 Jagged 1 Jag1 1.90 NM_080577 Nuclear protein localization 4 Npl4 1.78 1.92 NM_013141 Peroxisome proliferator activated receptor delta Ppard 1.94 NM_013413 Relaxin 1 Rln1 2.28 NM_031123 Stanniocalcin 1 Stc1 3.20 6.94 AA799664 V-akt murine thymoma viral oncogene homolog 1 Akt1 0.56 AA946508 Murine thymoma viral (v-akt) oncogene homolog 2 Akt2 0.64

NM_012904 A1 Anxa1 2.14 1.64 1.74 3.87 AF046886 Axl receptor tyrosine Axl 2.01 2.98 BF398424 B7-H3 B7h3 2.08 AW914973 Basic leucine zipper and W2 domains 1 Bzw1 2.00 2.41 NM_012920 Calcium/-dependent II Camk2a 2.31 alpha subunit NM_012519 Calcium/calmodulin-dependent protein kinase II, Camk2d 0.69 delta NM_012922 Caspase 3 Casp3 2.02 2.01 L09752 D2 Ccnd2 1.89 NM_012923 Cyclin G1 Ccng1 1.64 X83579 Cyclin-dependent kinase 7 (homolog of Xenopus Cdk7 0.61 MO15 cdk-activating kinase) NM_080782 Cyclin-dependent kinase inhibitor 1A Cdkn1a 2.64 3.59 NM_031762 Cyclin-dependent kinase inhibitor 1B Cdkn1b 2.28 AI169377 COP9 (constitutive photomorphogenic) homolog, Cops2 1.66 subunit 2 (Arabidopsis thaliana) NM_022683 Cullin 5 Cul5 2.01 AA858862 V-erb-b2 erythroblastic leukemia viral oncogene Erbb2 0.54 0.42 homolog 2, neuro/glioblastoma derived oncogene homolog (avian) NM_133397 V-ets erythroblastosis virus E26 oncogene like Erg 0.31 (avian) NM_012555 V-ets erythroblastosis virus E26 oncogene Ets1 3.36 homolog 1 (avian) NM_024146 Fibroblast growth factor receptor 1 Fgfr1 3.47 5.41 AW915240 FBJ murine osteosarcoma viral oncogene Fos 2.31 1.96 homolog BE108192 G1 to S phase transition 1 Gspt1 1.86 2.28 AW535136 Hepatoma-derived growth factor, related protein 3 Hdgfrp3 0.66 NM_031514 Janus kinase 2 Jak2 2.21 NM_021835 V-jun sarcoma virus 17 oncogene homolog (avian) Jun 1.93 3.42

NM_031515 Kirsten rat sarcoma viral oncogene homologue 2 Kras2 2.54 (active) AA875041 Leucine zipper, putative tumor suppressor 1 Lzts1 0.52 AJ005424 Mitogen-activated protein kinase 7 Mapk7 1.48

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Downloaded from iovs.arvojournals.org on 09/27/2021 BF550292 Mini maintenance deficient 4 Mcmd4 2.63 0.63 3.25 homolog (S. cerevisiae) NM_031517 Met proto-oncogene Met 6.62 5.61 NM_012603 Myelocytomatosis viral oncogene homolog (avian) Myc 2.80 5.88

NM_012992 Nucleophosmin 1 Npm1 2.48 AA851914 Neuroblastoma RAS viral (v-ras) oncogene Nras 0.68 homolog NM_012760 Pleiomorphic adenoma -like 1 Plagl1 3.40 NM_013065 1, catalytic subunit, beta Ppp1cb 1.84 2.10 isoform BF408792 Protein phosphatase 2a, catalytic subunit, alpha Ppp2ca 1.53 isoform AW914922 Protein phosphatase 3, catalytic subunit, alpha Ppp3ca 2.43 isoform NM_133589 Protein phosphatase V Ppp6c 2.08 BE096047 , member RAS oncogene family Ran 0.52 NM_031816 Retinoblastoma binding protein 7 Rbbp7 0.66 AW921320 -glutamic acid dipeptide (RE) repeats Rere 1.88 NM_054008 Rgc32 0.53 BE116582 Rho-associated coiled-coil forming kinase 2 Rock2 0.47 1.89 0.59 2.31 AI412015 Ribonucleotide reductase M1 Rrm1 1.70 NM_031683 Structural maintenance of 1 like 1 Smc1l1 1.71 (S. cerevisiae) NM_012671 Transforming growth factor alpha Tgfa 0.51 NM_012892 Amiloride-sensitive cation channel 1, neuronal Accn1 0.55 (degenerin) NM_020306 A disintegrin and metalloproteinase domain 17 Adam17 0.73 (tumor necrosis factor, alpha, converting )

NM_021850 Bcl2-like 2 Bcl2l2 2.59 2.11 NM_053736 Caspase 11 Casp4 0.72 NM_012699 DnaJ (Hsp40) homolog, subfamily B, member 9 Dnajb9 2.06 AI639157 I Dnase1 0.51 BE116848 Guanine binding protein, alpha q Gnaq 1.85 polypeptide AW253339 Huntingtin interacting protein 1 Hip1 1.90 NM_012588 Insulin-like growth factor binding protein 3 Igfbp3 2.17 NM_012589 Interleukin 6 Il6 2.20 NM_130741 Lipocalin 2 Lcn2 0.74 NM_012861 O-6-methylguanine-DNA methyltransferase Mgmt 0.54 0.43 NM_012610 Nerve growth factor receptor (TNFR superfamily, Ngfr 4.34 member 16) NM_017180 Pleckstrin homology-like domain, family A, Phlda1 2.37 member 1 AW142667 Retinoic acid receptor, alpha Rara 1.41 NM_031098 Rho-associated coiled-coil forming kinase 1 Rock1 2.55 2.59 NM_030836 Type 1 tumor necrosis factor receptor shedding Arts1 2.20 0.60 regulator

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_031503 Achaete-scute complex homolog-like 2 Ascl2 0.62 (Drosophila) NM_017178 Bone morphogenetic protein 2 Bmp2 1.52 AI179372 Bone morphogenetic protein receptor, type 1A Bmpr1a 1.91 D88250 Complement component 1, s subcomponent C1s 2.88 U44948 Cysteine and glycine-rich protein 2 Csrp2 0.36 NM_057144 Cysteine-rich protein 3 Csrp3 3.84 U09229 Cut-like 1 (Drosophila) Cutl1 1.97 NM_021775 Endothelial differentiation, sphingolipid G-protein- Edg8 0.54 0.42 coupled receptor, 8 NM_012551 Early growth response 1 Egr1 18.5 5.45 2 AI102517 Fst 2.68 BF282574 Growth hormone receptor Ghr 0.75 0.60 NM_031034 Guanine nucleotide binding protein, alpha 12 Gna12 3.10 AW920501 High mobility group box transcription factor 1 Hbp1 1.95 NM_024359 Hypoxia inducible factor 1, alpha subunit Hif1a 2.29 NM_013062 Kinase insert domain protein receptor Kdr 0.45 0.34 X60370 -associated protein 1b Map1b 0.41 BG667856 Myeloid-associated differentiation marker Myadm 2.34 1.81 AF228043 Nuclear receptor coactivator 6 Ncoa6 5.02 5.21 NM_012987 Nes 3.27 NM_019218 Neurogenic differentiation 1 Neurod1 2.17 NM_012609 Neurofibromatosis 1 Nf1 3.08 2.48 NM_017198 P21 (CDKN1A)-activated kinase 1 Pak1 1.81 NM_017042 Protein phosphatase 3, catalytic subunit, beta Ppp3cb 2.04 isoform AW915692 ROD1 regulator of differentiation 1 (S. pombe) Rod1 2.05 NM_017325 Runt related transcription factor 1 Runx1 6.09 NM_031114 S100 calcium binding protein A10 (calpactin) S100a1 2.64 0 BE113233 Suppressor of cytokine signaling 2 Socs2 2.68 BE109016 SRY-box containing gene 11 Sox11 1.74 AI012356 Signal transducer and activator of transcription 3 Stat3 0.56 BF412073 T-cell lymphoma invasion and 1 Tiam1 2.39 (predicted) NM_030998 Anti-Mullerian hormone type 2 receptor Amhr2 0.41 0.32 NM_031018 Activating transcription factor 2 Atf2 1.78 3.29 NM_053328 Basic helix-loop-helix domain containing, class B2 Bhlhb2 3.22 2.79

NM_021670 Bone morphogenetic protein 15 Bmp15 0.66 1.92 AI599641 Bromodomain-containing 2 Brd2 2.07 2.25 NM_031689 , beta A4 Cryba4 0.28 0.37 BE109161 DEK oncogene (DNA binding) Dek 0.65 NM_031066 Fasciculation and elongation protein zeta 1 (zygin Fez1 0.46 I) AW919132 Rapostlin Fnbp1 1.97 NM_012793 Guanidinoacetate methyltransferase Gamt 0.42 0.21 NM_024375 Growth differentiation factor 10 Gdf10 0.46 NM_031033 Guanine nucleotide binding protein, alpha 11 Gna11 1.48

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_013134 3-hydroxy-3-methylglutaryl-Coenzyme A Hmgcr 2.00 reductase NM_021863 Heat shock protein 2 Hspa2 2.24 NM_052807 Insulin-like growth factor 1 receptor Igf1r 2.88 2.55 M92340 Interleukin 6 signal transducer Il6st 7.30 6.28 BF523660 Type I KA13 Ka13 0.32 0.34 NM_053667 Leprecan 1 Lepre1 0.69 NM_013136 Male germ cell-associated kinase Mak 2.45 2.41 NM_138530 MAWD binding protein Mawbp 0.65 X89603 Metallothionein 3 Mt3 0.34 0.23 BF281834 Musculoskeletal, embryonic nuclear protein 1 Mustn1 0.55 AF002281 PDZ and LIM domain 3 Pdlim3 0.42 NM_053554 Phosphatidylinositol binding assembly Picalm 2.55 protein NM_013085 Plasminogen activator, Plau 4.31 17.1 9 Y07783 ER Dri 42 Ppap2b 1.92 AI172465 Protein tyrosine phosphatase, non-receptor type Ptpn11 0.62 11 NM_013080 Protein tyrosine phosphatase, receptor-type, Z Ptprz1 2.52 polypeptide 1 NM_013135 RAS p21 protein activator 1 Rasa1 3.93 4.70 NM_019214 Solute carrier family 26, member 4 Slc26a4 2.19 AA892798 Uterine sensitization-associated gene 1 protein Sostdc1 0.25 NM_013176 Transcription factor 12 Tcf12 2.59 3.02 AW532652 Transcription factor 4 Tcf4 2.01 NM_021989 Tissue inhibitor of metalloproteinase 2 Timp2 2.04 D14046 Topoisomerase II beta Top2b 9.17 9.72 AF047707 UDP-glucose ceramide glucosyltransferase Ugcg 3.73 2.56 NM_031615 Zinc finger protein 148 Znf148 2.08 NM_012504 ATPase, Na+/K+ transporting, alpha 1 polypeptide Atp1a1 4.36 3.86

NM_012505 ATPase, Na+/K+ transporting, alpha 2 polypeptide Atp1a2 0.24

NM_012549 Endothelin 2 Edn2 0.13 NM_022936 Epoxide 2, cytoplasmic Ephx2 1.61 NM_021751 Prominin 1 Prom1 2.63 3.16 U41853 Hypoxia up-regulated 1 Hyou1 2.11 2.95 NM_012780 Aryl hydrocarbon receptor nuclear translocator Arnt 1.68 2.09 NM_013069 CD74 antigen (invariant polpypeptide of major Cd74 0.45 0.60 histocompatibility class II antigen-associated) NM_012844 Epoxide hydrolase 1 Ephx1 1.53 0.54 0.33 NM_012724 Fc receptor, IgE, high affinity I, alpha polypeptide Fcer1a 0.47 0.27 AA955206 Fibrinogen-like 2 Fgl2 0.67 1.95 NM_133624 Guanylate nucleotide binding protein 2 Gbp2 0.48 L05175 Granzyme M (lymphocyte met-ase 1) Gzmm 1.93 NM_020096 Interferon-induced protein with tetratricopeptide Ifit1 2.58 3.46 repeats 1 NM_053518 Lysosomal trafficking regulator Lyst 1.85 NM_012771 Lysozyme Lyz 0.59

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_031020 Mitogen activated protein kinase 14 Mapk14 2.20 Z18877 2',5'-oligoadenylate synthetase 1, 40/46kDa Oas1 1.86 2.49 NM_017139 Preproenkephalin, related sequence Penk-rs 0.44 NM_031640 Plasma glutamate Pgcp 0.58 NM_019335 Protein kinase, interferon-inducible double Prkr 2.37 3.32 stranded RNA dependent NM_021696 (or cysteine) proteinase inhibitor, clade B, Serpinb 2.35 9.19 member 2 2 AW915763 Serine (or cysteine) proteinase inhibitor, clade G Serping 1.38 (C1 inhibitor), member 1, (angioedema, 1 hereditary) AI600013 Superoxide dismutase 2, mitochondrial Sod2 1.92 2.76 NM_032056 Transporter 2, ATP-binding cassette, sub-family B Tap2 2.44 (MDR/TAP) AJ238278 Exportin 1, CRM1 homolog (yeast) Xpo1 2.19 NM_012919 Calcium channel, voltage-dependent, alpha2/delta Cacna2 2.41 subunit 1 d1 NM_133597 Cholinergic receptor, nicotinic, beta polypeptide 3 Chrnb3 1.96

BE098848 Chloride intracellular channel 4 Clic4 1.70 2.15 NM_053497 Cyclic nucleotide-gated cation channel Cnga1 0.69 AW915689 Cytochrome b-245, beta polypeptide Cybb 2.07 AI009597 FXYD domain-containing ion transport regulator 3 Fxyd3 0.21 NM_019309 Glutamate receptor, ionotropic, kainate 2 Grik2 0.39 J04731 Potassium voltage-gated channel, shaker-related Kcna2 0.38 subfamily, member 2 NM_031739 Potassium voltage gated channel, Shal-related Kcnd3 1.63 family, member 3 NM_053608 Potassium inwardly-rectifying channel, subfamily Kcnj13 0.46 J, member 13 BF407757 Potassium channel tetramerisation domain Kctd3 0.64 0.62 containing 3 (predicted) AF130881 3 Ryr3 0.55 AW918387 ATP-binding cassette, sub-family A (ABC1), Abca1 3.56 member 1 NM_012804 ATP-binding cassette, sub-family D (ALD), Abcd3 1.54 member 3 NM_022193 Acetyl-coenzyme A carboxylase alpha Acaca 2.19 2.14 NM_016986 Acetyl-coenzyme A dehydrogenase, medium Acadm 0.74 chain AI172057 Acyl-Coenzyme A dehydrogenase, short/branched Acadsb 0.51 chain D90109 Acyl-CoA synthetase long-chain family member 1 Acsl1 1.70

NM_057107 Acyl-CoA synthetase long-chain family member 3 Acsl3 2.24

NM_053607 Acyl-CoA synthetase long-chain family member 5 Acsl5 2.42

M87067 IIB Acvr2b 2.26 NM_031006 Adenosine deaminase, RNA-specific Adar 2.48

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_019285 Adenylate 4 Adcy4 1.77 2.22 NM_031552 Adducin 3 (gamma) Add3 2.44 BF408893 Adenylate kinase 3 Ak3 1.82 2.98 NM_013215 Aldo-keto reductase family 7, member A3 Akr7a3 0.41 0.36 (aflatoxin aldehyde reductase) NM_019363 Aldehyde oxidase 1 Aox1 0.34 NM_012738 Apolipoprotein A-I Apoa1 0.52 NM_019168 Arginase 2 Arg2 0.41 NM_024399 Aspartoacylase Aspa 0.61 0.63 NM_012912 Activating transcription factor 3 Atf3 1.84 5.17 NM_053311 ATPase, Ca++ transporting, plasma membrane 1 Atp2b1 1.71

NM_131907 ATPase, Ca++-sequestering Atp2c1 2.86 2.94 NM_019204 Beta-site APP cleaving enzyme Bace 2.50 2.21 NM_031338 Calcium/calmodulin-dependent protein kinase Camkk2 1.64 0.50 1.82 kinase 2, beta L18889 Canx 3.29 3.07 NM_017116 2 Capn2 7.04 10.8 8 NM_053295 Calpastatin Cast 1.91 NM_052809 Cytosolic cysteine dioxygenase 1 Cdo1 0.40 NM_031987 Carnitine O-octanoyltransferase Crot 3.13 3.24 NM_053335 C-terminal binding protein 2 Ctbp2 2.54 NM_017097 Ctsc 2.26 3.55 Y00697 Cathepsin L Ctsl 3.29 NM_022245 Cytochrome b-5 Cyb5 0.56 NM_017210 Deiodinase, iodothyronine, type III Dio3 0.56 X94186 Dual specificity phosphatase 7 Dusp7 1.72 NM_078623 Enoyl Coenzyme A hydratase, short chain, 1, Echs1 0.55 mitochondrial BE107334 Eukaryotic translation 1 alpha 1 Eef1a1 1.72 NM_031599 Eukaryotic translation initiation factor 2 alpha Eif2ak3 2.15 2.22 kinase 3 BF409371 Eukaryotic translation initiation factor 2 alpha Eif2ak4 0.65 kinase 4 (predicted) AI178647 Eukaryotic translation initiation factor 2, subunit 2 Eif2s2 0.55 0.59 beta, 38kDa BG671456 ELOVL family member 6, elongation of long chain Elovl6 3.71 3.14 fatty acids (yeast) X78689 EphA5 Epha5 2.43 NM_053849 Protein disulfide related protein Erp70 2.15 2.28 (calcium-binding protein, intestinal-related) BF285301 Eukaryotic translation termination factor 1 Etf1 0.69 (predicted) NM_017005 Fumarate hydratase 1 Fh1 0.62 NM_133527 Folate receptor 1 (adult) Folr1 1.76 NM_053567 Formiminotransferase cyclodeaminase Ftcd 0.35 0.33 NM_012563 Glutamate decarboxylase 2 Gad2 3.54 AA818089 Glycyl-tRNA synthetase (predicted) Gars 0.74 0.61 AI105210 Geranylgeranyl diphosphate synthase 1 Ggps1 1.84

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_012569 Glutaminase Gls 4.09 2.71 NM_012570 Glutamate dehydrogenase 1 Glud1 2.15 NM_057188 Guanosine monophosphate reductase Gmpr 0.44 NM_017274 Glycerol-3-phosphate acyltransferase, Gpam 1.71 mitochondrial NM_017113 Granulin Grn 1.51 NM_017090 1, soluble, alpha 3 Gucy1a 1.86 3 NM_024380 Guanylyl cyclase 2e Gucy2e 1.51 NM_053831 Guanylate cyclase 2f Gucy2f 3.15 NM_024381 Glycerol kinase Gyk 0.61 3.87 0.60 4.66 NM_057186 L-3-hydroxyacyl-Coenzyme A dehydrogenase, Hadhsc 0.42 short chain M33648 3-hydroxy-3-methylglutaryl-Coenzyme A synthase Hmgcs2 0.27 2 AA848820 15-hydroxyprostaglandin dehydrogenase Hpgd 0.71 NM_013159 Insulin degrading enzyme Ide 1.80 1.90 AI175457 Itchy homolog E3 ubiquitin protein Itch 0.44 0.45 NM_031045 Inositol 1,4,5-trisphosphate 3-kinase A Itpka 0.28 AJ000556 Janus kinase 1 Jak1 7.75 6.38 NM_012594 Lactalbumin, alpha Lalba 1.97 AA944176 Leucyl-tRNA synthetase (predicted) Lars 1.50 NM_017024 Lecithin cholesterol acyltransferase Lcat 0.48 0.52 NM_031727 LIM motif-containing protein kinase 1 Limk1 0.36 NM_133574 Aminopeptidase Vp165 Lnpep 1.58 NM_130822 Calcium-independent alpha-latrotoxin receptor Lphn3 1.89 homolog 3 NM_021586 Latent transforming growth factor beta binding Ltbp2 2.02 protein 2 NM_017322 Mitogen-activated protein kinase 9 Mapk9 0.64 NM_021699 Serine/ kinase Mark2 1.93 AI763565 Monoglyceride Mgll 1.98 BE103304 related protein 9 Mtmr9 1.76 NM_031062 Mevalonate (diphospho) decarboxylase Mvd 1.43 NM_057209 Myosin chain kinase 2, Mylk2 0.66 BF406213 NADH dehydrogenase (ubiquinone) 1 alpha Ndufa5 0.62 subcomplex 5 NM_012993 N-arginine dibasic convertase 1 Nrd1 0.66 0.54 NM_021748 N-ethylmaleimide sensitive fusion protein Nsf 1.81 NM_053598 Nudix (nucleoside diphosphate linked moiety X)- Nudt4 1.82 type motif 4 BF404478 , cytoskeletal calmodulin and - Obscn 0.46 interacting RhoGEF NM_012615 Ornithine decarboxylase 1 Odc1 2.36 U76557 O-linked N-acetylglucosamine (GlcNAc) Ogt 0.48 1.91 (UDP-N- acetylglucosamine:polypeptide-N- acetylglucosaminyl transferase) NM_057153 Oxidation resistance 1 Oxr1 2.15 NM_053306 P21 (CDKN1A)-activated kinase 2 Pak2 2.54 2.33

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Downloaded from iovs.arvojournals.org on 09/27/2021 AB019366 Poly (ADP-ribose) glycohydrolase Parg 0.53 NM_031081 3-phosphoinositide dependent protein kinase-1 Pdpk1 7.43 1.84 NM_031769 Pyridoxal (pyridoxine, vitamin B6) kinase Pdxk 1.78 NM_013151 Plasminogen activator, tissue Plat 2.94 NM_031347 Peroxisome proliferative activated receptor, Ppargc1 0.41 gamma, coactivator 1 alpha a NM_033096 Protein phosphatase 1B, magnesium dependent, Ppm1b 2.28 beta isoform NM_053512 Peroxiredoxin 4 Prdx4 1.49 NM_012634 Phosphoribosyl pyrophosphate synthetase 2 Prps2 2.33 2.25 NM_017281 Proteasome (prosome, macropain) subunit, alpha Psma4 2.00 type 4 NM_021583 Prostaglandin E synthase Ptges 2.50 NM_057115 Protein tyrosine phosphatase, non-receptor type Ptpn12 1.86 2.99 12 AI233267 Pumilio 2 (Drosophila) (predicted) Pum2 0.60 1.65 NM_053431 Quiescin Q6 Qscn6 3.18 3.60 NM_031095 Renin binding protein Renbp 0.54 0.50 NM_031100 Ribosomal protein L10 Rpl10 0.73 NM_017160 Ribosomal protein S6 Rps6 2.39 BF282458 Receptor-like tyrosine kinase Ryk 0.46 0.54 BF408094 Sialyltransferase 7 ((alpha-N-acetylneuraminyl Siat7A 0.51 2,3-beta-galactosyl-1,3)-N-acetyl galactosaminde alpha-2,6-sialyltransferase) A NM_057156 Sialyltransferase 8 (alpha-2, 8-sialyltransferase) B Siat8b 3.31

M97380 Solute carrier family 18 (vesicular monoamine), Slc18a1 0.67 member 1 NM_017316 Solute carrier family 23 (nucleobase transporters), Slc23a2 2.26 member 2 BE109671 Solute carrier family 3, member 1 Slc3a1 0.70 0.59 NM_021693 SNF1-like kinase Snf1lk 2.17 M36410 Sepiapterin reductase Spr 0.48 0.49 NM_022711 Steroid 5-alpha-reductase 2 Srd5a2 2.14 AA819716 1 Synj1 1.94 NM_031693 4 Syt4 1.77 M61142 Thimet oligopeptidase 1 Thop1 1.55 U89531 Titin Ttn 1.94 BF283053 Thioredoxin domain containing 7 Txndc7 0.64 NM_031614 Thioredoxin reductase 1 Txnrd1 3.44 4.64 NM_017237 Ubiquitin carboxy-terminal hydrolase Uchl1 0.54 0.44 NM_053418 Ubiquitin fusion degradation 1-like Ufd1l 0.70 NM_133596 UDP-glucose ceramide glucosyltransferase-like 1 Ugcgl1 1.70

BF550847 UDP glycosyltransferase 1 family, polypeptide A6 Ugt1a6 0.52

NM_053845 Ureidopropionase, beta Upb1 0.49 AF106658 Ubiquitin specific 2 Usp2 2.16 AI009197 Vitamin K epoxide reductase complex, subunit 1 Vkorc1 0.43 NM_013155 Very low density lipoprotein receptor Vldlr 2.02 2.19

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Downloaded from iovs.arvojournals.org on 09/27/2021 AI137819 YME1-like 1 (S. cerevisiae) Yme1l1 1.92 2.14 NM_019376 Tyrosine 3-monooxgenase/tryptophan 5- Ywhag 2.09 monooxgenase activation protein, gamma polypeptide AI180275 Angiotensin II receptor-associated protein Agtrap 0.45 0.33 NM_013132 Anxa5 2.87 NM_031711 ADP-ribosylation factor-like 2 Arl2 0.53 0.39 M59967 Bradykinin receptor b2 Bdkrb2 2.40 NM_019359 Calponin 3, acidic Cnn3 0.62 AA900434 Endothelin receptor type A Ednra 0.52 0.47 NM_053633 Early growth response 2 Egr2 2.75 AF335571 Echinoderm microtubule associated protein like 2 Eml2 1.81

NM_013057 Coagulation factor 3 F3 1.93 NM_022675 FK506 binding protein 1b Fkbp1b 0.36 NM_013106 Guanine nucleotide binding protein, alpha Gnai3 1.70 2.02 inhibiting 3 AF077354 Heat shock protein 4 Hspa4 0.45 M14050 Heat shock 70kD protein 5 Hspa5 2.09 BE108905 Nucleosome assembly protein 1-like 1 Nap1l1 2.28 2.48 NM_017031 4B Pde4b 4.34 3.29 AF021923 Solute carrier family 24 Slc24a2 2.90 3.18 (sodium/potassium/calcium exchanger), member 2

NM_012761 Sp4 transcription factor Sp4 4.75 BF401593 II Syn2 0.55 NM_133579 Zinc finger protein 22 (KOX 15) Znf22 2.22 2.34 NM_031150 Zona pellucida 2 Zp2 0.58 NM_080697 light chain-2 Dlc2 0.50 AA946350 Guanine nucleotide binding protein, alpha Gnai1 1.77 inhibiting 1 NM_012984 Myosin IXb Myo9b 0.69 NM_133536 RAB3C, member RAS oncogene family Rab3c 0.41 AF002251 Ras association (RalGDS/AF-6) domain family 5 Rassf5 0.63 NM_052829 Regulating synaptic membrane exocytosis 1 RIMS1 0.56 0.49 NM_053427 Solute carrier family 17 (sodium-dependent Slc17a6 0.58 inorganic phosphate cotransporter), member 6 NM_017206 Solute carrier family 6 (neurotransmitter Slc6a6 3.29 transporter, taurine), member 6 NM_012664 Syp 0.59 NM_031008 Adaptor protein complex AP-2, alpha 2 subunit Ap2a2 2.17 BF550401 Chaperonin containing TCP1, subunit 5 (epsilon) Cct5 0.47 NM_053891 Cyclin-dependent kinase 5, regulatory subunit 1 Cdk5r 1.83 (p35) NM_053989 dd5 2.57 2.79 NM_032079 DnaJ (Hsp40) homolog, subfamily A, member 2 Dnaja2 0.66 NM_021865 Jun dimerization protein 1 Jdp1 2.04 AF084205 Serine/threonine protein kinase TAO1 LOC286 1.49 993 AI412239 McKusick-Kaufman syndrome protein (predicted) Mkks 0.46

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Downloaded from iovs.arvojournals.org on 09/27/2021 AI073176 Similar to Mkrn1 protein Mkrn1 1.55 AI230431 Stress 70 protein chaperone, microsome- Stch 1.50 0.64 associated, 60kD homolog AF205438 Tribbles homolog 1 (Drosophila) Trib1 2.66 2.51 BE115860 Tripartite motif protein 2 (predicted) Trim2 2.66 2.17 1.75 NM_031827 Vesicle-associated 8 Vamp8 0.58 0.52 NM_057211 Basic transcription element binding protein 1 Bteb1 2.74 2.95 AW915020 CCAAT/enhancer binding protein (C/EBP), delta Cebpd 0.59 0.54 X64403 CCAAT/enhancer binding protein (C/EBP), Cebpg 2.16 gamma NM_053699 Cbp/p300-interacting transactivator, with Glu/Asp- Cited4 0.34 0.34 rich carboxy-terminal domain, 4 NM_019137 Early growth response 4 Egr4 2.66 4.22 NM_012953 Fos-like antigen 1 Fosl1 3.12 3.12 NM_022208 General transcription factor 2a, 1 Gtf2a1 2.18 AI228222 General transcription factor IIF, polypeptide 2 Gtf2f2 0.62 0.47 NM_057141 Heterogeneous nuclear ribonucleoprotein K Hnrpk 2.06 1.99 NM_053713 Kruppel-like factor 4 (gut) Klf4 6.67 11.5 2 NM_053394 Kruppel-like factor 5 Klf5 1.51 2.97 AI010660 Lymphoblastic leukemia derived sequence 1 Lyl1 0.41 U48809 Myelin transcription factor 1-like Myt1l 1.95 NM_022856 Ngfi-A binding protein 1 Nab1 3.38 3.70 NM_031822 Nuclear receptor coactivator 2 Ncoa2 1.74 U20796 Nuclear receptor subfamily 1, group D, member 2 Nr1d2 4.96 3.99

NM_080778 Nuclear receptor subfamily 2, group F, member 2 Nr2f2 2.10 1.99 L06821 Nucleoporin 153kD Nup153 1.64 1.86 NM_024489 Zinc finger protein RIN ZF Rinzf 2.05 BE118450 Retinoid X receptor gamma Rxrg 0.30 NM_133615 TAF9-like RNA polymerase II, TATA box binding Taf9l 1.54 protein (TBP)-associated factor, 31kDa AW918369 Zinc finger protein 191 Zfp191 2.79 NM_133620 Zinc-fingers and homeoboxes 1 Zhx1 1.50 AB003104 Beaded filament structural protein 1 Bfsp1 0.55 0.33 NM_053662 Cyclin L1 Ccnl1 1.56 NM_134353 Poly(A) binding protein, cytoplasmic 1 Pabpc1 2.02 NM_021757 Pleiotropic regulator 1 homolog (Arabidopsis) Plrg1 0.74 NM_057119 Splicing factor, arginine/serine-rich 10 Sfrs10 2.05 (transformer 2 homolog, Drosophila) AW914860 Threonyl-tRNA synthetase Tars 1.82 AJ277881 ATP-binding cassette, sub-family C (CFTR/MRP), Abcc1 2.56 2.30 2.19 member 1 NM_080581 ATP-binding cassette, sub-family C (CFTR/MRP), Abcc3 0.46 member 3 NM_031007 Adenylate cyclase 2 Adcy2 2.73 AI233818 A kinase (PRKA) anchor protein (gravin) 12 Akap12 2.17 3.28 NM_080904 ADP-ribosylation factor 3 Arf3 2.25 2.56 NM_024151 ADP-ribosylation factor 4 Arf4 0.73 1.99 2.13 BE111827 Rho GTPase activating protein 4 Arhgap4 0.47

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Downloaded from iovs.arvojournals.org on 09/27/2021 NM_021694 Rho guanine nucleotide exchange factor (GEF) 1 Arhgef1 2.09 2.52 BI282724 Arginine vasopressin-induced 1 Avpi1 0.39 AF387513 BMP and activin membrane-bound inhibitor, Bambi 0.46 homolog (Xenopus laevis) NM_053342 CXXC finger 4 Cxxc4 1.47 NM_019622 Espn 1.54 0.47 NM_017276 GDP dissociation inhibitor 2 Gdi2 2.09 2.39 BG665133 Guanine nucleotide binding protein, gamma 2 Gng2 0.53 AF107723 G-protein signalling modulator 1 (AGS3-like, C. Gpsm1 2.45 3.21 elegans) NM_012964 Hyaluronan mediated motility receptor Hmmr 3.40 2.51 NM_012852 5-hydroxytryptamine (serotonin) receptor 1D Htr1d 0.51 NM_012765 5-hydroxytryptamine (serotonin) receptor 2C Htr2c 2.48 AI178808 Interleukin 2 receptor, gamma (severe combined Il2rg 2.57 immunodeficiency) BE107622 family member 1B Kif1b 2.71 1.88 U92010 Lin-10 protein homolog (C. elegans) Lin10 0.45 NM_021758 Lin-7 homolog b (C. elegans) Lin7b 0.45 0.34 NM_030856 Leucine rich repeat protein 3, neuronal Lrrn3 1.77 NM_021587 Latent transforming growth factor beta binding Ltbp1 0.42 protein 1 BE120595 Spermatogenesis-related protein (Srp) Mki67ip 0.63 BF405725 MAS-related GPR, member F Mrgprf 2.50 2.06 NM_012983 Myosin IC Myo1c 0.50 NM_017294 and casein kinase substrate in Pacsin1 1.53 1 NM_012627 Protein kinase (cAMP dependent, catalytic) Pkib 0.55 inhibitor beta NM_017350 Plasminogen activator, Plaur 2.90 8.32 NM_017359 RAB10, member RAS oncogene family Rab10 1.46 AW918990 RAB21, member RAS oncogene family Rab21 1.92 1.85 AF148210 RAB6B, member RAS oncogene family Rab6 3.35 3.33 AA848305 RAS related protein 1b Rap1b 2.10 3.02 NM_017214 Regulator of G-protein signaling 4 Rgs4 1.79 NM_019341 Regulator of G-protein signaling 5 Rgs5 1.68 0.37 NM_017062 Reversion induced LIM gene Ril 0.65 BE113224 Signal sequence receptor, gamma Ssr3 2.08 NM_024346 -like 3 Stmn3 0.49 NM_016990 Adducin 1 (alpha) Add1 2.27 AI172165 Peroxisomal protein Fndc5 0.50 NM_053371 Fractured callus expressed transcript 1 Fxc1 0.52 AB005052 Huntingtin interacting protein 1 related Hip1r 0.44 0.35 BF288776 Microtubule-associated 1A/1B light chain Map1lc3 1.98 2.28 3 b NM_017204 Microtubule-associated protein 6 Mtap6 3.55 NM_017029 3, medium Nef3 0.37 NM_030873 2 Pfn2 0.62 X70706 Plastin 3 (T-isoform) Pls3 2.54 3.40 NM_053508 1 Tekt1 0.42

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Downloaded from iovs.arvojournals.org on 09/27/2021 AI045600 Translocating chain-associating membrane protein Tram1 2.83

NM_031140 Vim 2.00 1.69 NM_031142 Double C2, beta Doc2b 1.76 L20823 Epimorphin Epim 0.65 NM_031685 Golgi SNAP receptor complex member 2 Gosr2 1.96 1.96 NM_017063 Karyopherin (importin) beta 1 Kpnb1 1.70 2.03 AB011533 Low density lipoprotein receptor-related protein 4 Lrp4 1.79 NM_053952 Nucleoporin 155 Nup155 1.84 NM_031726 Secretory carrier membrane protein 5 Scamp5 0.51 NM_019277 SEC15-like 1 (S. cerevisiae) Sec15l1 0.67 AJ132846 Sodium-dependent neutral transporter Slc1a5 3.08 7.16 ASCT2 AA892522 Solute carrier family 25, member 30 Slc25a3 0.35 0.49 0 NM_017102 Solute carrier family 2 (facilitated glucose Slc2a3 1.65 transporter), member 3 Y16774 Solute carrier family 30 (zinc transporter), member Slc30a4 2.08 4 BF522212 Solute carrier family 35, member B2 Slc35b2 2.00 2.88 NM_058211 Solute carrier family 4, sodium bicarbonate Slc4a7 2.21 cotransporter, member 7 NM_017217 Solute carrier family 7 (cationic amino acid Slc7a3 0.37 transporter, y+ system), member 3 AI176311 Trans-golgi network protein 1 Tgoln2 0.58 AI179901 Transmembrane 9 superfamily member 2 Tm9sf2 1.66 AI177431 Rac/ guanine nucleotide exchange factor 6 arhgef6 0.62 BF393972 Breast carcinoma amplified sequence 1 Bcas1 0.60 0.37 BF388912 Collagen, type XXVII, alpha 1 Col27a1 0.50 NM_080399 DNA-damage-inducible transcript 4-like Ddit4l 0.41 0.42 U53184 LPS-induced TNF-alpha factor Litaf 0.44 BE113306 Ng23 protein Ng23 0.43 AA944542 Peroxisomal membrane protein 4 Pxmp4 1.60 AI317840 Ring finger protein 138 Rnf138 0.72

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