http://www.nesacs.org

November 2018 Vol. XCVII, No.3

Monthly Meeting

2018 Norris Award to Gerard Parkin at Simmons University Raj Rajur Receives 2018 Henry A. Hill Award September Meeting Report

By Mindy Levine Photos from the GDCh- NSYCC Exchange

By Brian D’Amico Dr. Arthur Obermayer and the Beginning of the Billion Dollar Small Business Innovative Research Program

By Jack Driscoll, Chair, Public Relations & Professional Development, NESACS In 1961, Arthur Obermayer started Mol- at the ACS National Meeting in Boston eculon Reseach, a contract research in 2018. It was part of the Small Chem- company. From 1961 to 1965, he ical Business Div. Program http://ana- worked with Henry Hill before Henry lyzersource.blogspot.com/2018/#!. moved his company, Riverside Re- which was held on Aug. 20, 2018. search, to Haverhill. Arthur was an avid We had seven speakers and were promoter of small businesses. fortunate to have Dr. Tom Connelly, Ex- He was very active in NESACS ecutive Director and CEO of the ACS, starting in the late 1950’s. He was a NE- open the program. These presentations SACS councilor, a trustee, and Chair in had a considerable amount of informa- 1982. In 1996 through Obermayer’s tion on the early history to present day (l-r): Madeleine Jacobs (ACS), Arthur Ober- leadership, NESACS was among the first mayer (presenter at the symposium and 60-year of the SBIR/STTR programs. local sections to set up its own website. member), Mukund Chorghade and Jack Driscoll During my research, I was amazed I met Dr. Arthur Obermayer for the (co-organizers of the symposium) to find that the SBIR/STTR program, first time in Oct. 2012 when I (along Photo credit: M. Hoffman which had been started in 1982 with a with Jennifer Maclachlan and Mukund rights to the SBIR awardees instead of $25,000 NSF award to Obermayer’s Chorgade) organized a Small Chemical the government. This was an incredible Moleculon was funded at 1.7% of the Business Symposium at Nova Biomed- result. Instead of the Intelectural Prop- Federal R&D budget in 2018 or $2.3 ical Corp. This symposium was sched- erty rights residing in a government billion dollars. From 1982 to 2018, the uled to run from 12 to 5 PM. warehouse, the private company would Federal Government invested $50 bill- This was the NESACS monthly have the right to patent and commercial- lion dollars in 25,000 awards to small meeting, which began at 4:30 PM and ize their successful project. businesses. What a boon to innovation the evening meeting, which involved the After the symposium, I asked the and small business!! We need to do recognition of 50- and 60-year members audience if anyone was aware of more to publicize Obermayer’s contri- as well as the presentation of the Henry Arthur’s accomplishments with regard bution to the SBIR program and hope- Hill Award. Arthur was to receive recog- to the SBIR. There were representatives fully this article is a good start. nition as a 60-year member of the ACS. from banks, venture capital, ACS SCHB, I am pleased that Dr. Obermayer He wanted to talk at the meeting but was and small businesses at the meeting. No gave his talk at our symposium because told that there was no time in the one in in the audience knew about this. he normally did not talk about the in- evening program. I was aware of a number of companies credible impact of the SBIR/STTR for I was asked if I could find a place that had successful SBIR’s and I called small businesses. He was clearly a cham- in our symposium for Arthur to speak. and asked them whether anyone knew pion for small business. We at NESACS Madeleine Jacobs, ACS Executive Di- about Arthur Obermayer and the SBIR. are very proud of the Obermayer’s con- rector and CEO, graciously agreed to Again no one was aware of this! We did tributions to small businesses which give up her slot to Arthur to talk about get Arthur’s remarks published in the today provide 40% of the jobs for scien- u the formation of the Small Business In- Dec. 2012 issue of the Nucleus. Ober- tists and engineers. novative Research (SBIR) Program. It mayer received the Henry Hill Award in was a great addition to our program. Oct. 2013. http://nesacs.org/pub_nucleus Arthur’s speech is printed in the Dec. /2013/Oct13.pdf Join 2012 edition of the Nucleus (http://ne- In July 2015 Arthur and Judith sacs.org/p ub_nucleus/2012/Dec2012. Obermayer were inducted into the SBA NESACS pdf ). Hall of Fame at a White House Cere- When I heard his speech, I was mony (http://www.mvtimes.com/2015/ on facebook amazed that he had been involved in 06/24/white-house-honors-chilmark- starting the SBIR program in 1982. I couple/) was also very surprised that he had been Sadly, in 2016, Arthur passed away. www.facebook.com/nesacs involved in the Bayh-Dole Patent Act a We organized a symposium in honor of few years later that gave the patent Dr. Obermayer and the SBIR Program

2 The Nucleus November 2018 The Northeastern Section of the American- Chemical Society, Inc. Contents Office: Anna Singer, 12 Corcoran Road, Burlington, MA 01803 (Voice or FAX) (781) 272-1966. Dr. Arthur Obermayer and the Beginning of the Billion Dollar Small e-mail: [email protected] NESACS Homepage: Business Innovative Research Program 2 http://www.NESACS.org ______Officers 2018 By Jack Driscoll, Chair, Public Relations & Professional Development, NESACS Chair Mindy Levine Recipients of the James Flack Norris Award 1951–2018 4 35 Cottage St ______Sharon, MA 02067-2130 (516) 697-9688 Monthly Meeting 5 [email protected] ______Chair-Elect Presentation of the 2018 James Flack Norris Award for Outstanding Achieve- Andrew Scholte Sanofi ment in the Teaching of Chemistry Waltham, MA (617) 459-5145 Raj Rajur Receives the 2018 Henry A. Hill Award 6 [email protected] ______Immediate Past Chair th Leland L. Johnson, Jr. American Chemical Society 256 National Meeting Boston, Euretos Massachusetts August 19-23, 2018 7 Cambridge, MA ______(617) 304.6474 [email protected] September 2018 Monthly Meeting 10 Secretary ______Michael Singer By Mindy Levine, 2018 Chair, Northeastern Section of the American Chemical MilliporeSigma 400 Summit Drive, Burlington, MA 01803 Society (781-229-7037), [email protected] Photos from the 2018 GDCh-NSYCC Exchange - Boston 12 Treasurer ______Ashis Saha Photos by Brian D'Amico 67 Bow St Arlington, MA 02474-2744 Medicinal Chemistry Group Hosts Symposium on The Future of (978) 212-5462 [email protected] Anti-Infectives 14 Auditor ______Patrick Gordon by Mindy Levine Archivist Ken Mattes Cover: Trustees Professor Gerard Parkin of Columbia University is the 2018 recipient Peter C. Meltzer, Dorothy Phillips, Ruth Tanner of the James Flack Norris Award for Outstanding Achievement in the Teaching of Directors-at-Large Chemistry. (Photo courtesy of Professor Parkin). David Harris, June Lum, Michael P. Filosa, John Neumeyer, James U. Piper, Ralph Scannell Editorial Deadlines: Councilors/Alternate Councilors January 2019 Issue: November 22, 2018 Term Ends 12/31/2018 February 2019 Issue: December 22, 2018 Katherine Lee Chris Moreton Catherine E. Costello Ajay Purohit Ruth Tanner June Lum Kenneth Mattes Malika Jeffries-EL Jackie O’Neil Joshua Sacher Term Ends 12/31/2019 Thomas R. Gilbert Ashis Saha Mary Jane Shultz Mary A. Mahaney Michael Singer Jerry P. Jasinski The Nucleus is published monthly, except June and August, by the Northeastern Section of the American Lisa Marcaurelle Raj (SB) Rajur Chemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Text Leland L. Johnson, Jr. Matthew M. Jacobsen must be received by the editor six weeks before the date of issue. Term Ends 12/31/2020 Michael P. Filosa Morton Z. Hoffman Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email: Carol Mulrooney Sonja Strah-Pleynet [email protected]; Tel: 508-843-9070 Patricia A. Mabrouk Andrew Scholtet Anna W. Sromek Patrick M. Gordon Associate Editors: Myron S. Simon, 60 Seminary Ave. apt 272, Auburndale, MA 02466 Sofia A. Santos Morton Z. Hoffman, 23 Williams Rd., Norton, MA 02766 Board of Publications: Ajay Purohit (Chair), Mary Mahaney, Ken Drew, Katherine Lee All Chairs of standing Business Manager: Vacant: contact Michael Filosa at [email protected] Committees, the editor of THE NUCLEUS, and Advertising Manager: Vacant: contact Michael Filosa at [email protected] the Trustees of Section Calendar Coordinator: Vacant: contact Michael Filosa at [email protected] Funds are members of the Photographers: Brian D’Amico Board of Directors. Any Coun cilor of the American Chemical Society Proofreaders: Donald O. Rickter, Morton Z. Hoffman residing within the section area is an ex officio Webmaster: Roy Hagen, Email: [email protected] member of the Board of Directors. Copyright 2018, Northeastern Section of the American Chemical Society, Inc.

The Nucleus November 2018 3 Recipients of the James NESACS Sponsors 2017 Platinum $5000+ Flack Norris Award Boston Foundation Esselen Award SK Life Science 1951–2018 Amgen, Inc Johnson Matthey Vertex Pharmaceuticals 1951 George Shannon Forbes 1985 Derek A. Davenport Davos Pharma 1953 John Xan 1986 Glenn A. Crosby Biogen 1955 Harry Nicholls Holmes 1987 Joseph B. Lambert PCI Synthesis 1956 Norris Watson Rakestraw 1988 Dana W. Mayo & Ronald M. Navin Fluorine International Ltd 1957 Emma Perry Carr & Mary Lura Pike Gold $3000 up to $5000 Sherrill 1989 Jerry R. Mohrig Merck Research Corp 1957 Farrington Daniels 1990 Joseph A. Schwarcz Signal Pharmaceuticals J-Star Research 1959 Herman Irving Schlesinger 1991 John W. Moore IPG Women Chemists 1959 Louis Frederick Fieser 1992 Jerry A. Bell Abbvie 1960 Louis Plack Hammett 1993 Arthur C. Breyer Silver $1500 up to $3000 1961 Joel Henry Hildebrand 1994 Samuel P. Massie Mettler Toledo 1962 Ralph Lloyd Shriner 1995 Michael P. Doyle Sanofi US Services 1963 Avery Allen Ashdown 1996 Mary Virginia Orna Warp Drive Bio Pfizer 1964 James Arthur Campbell & 1997 A. Truman Schwartz Lawrence Edward Strong LAVIANA 1998 Angelica M. Stacy Strem Chemicals 1965 Walter John Moore 1999 Joseph J. Lagowski Bronze $500 up to $1500 1966 John Arrend Timm & Edgar 2000 Billy Joe Evans Chemical Computing Group Bright Wilson 2001 Dennis G. Peters Xtuit Pharmaceuticals 1967 Edward Lauth Haenisch 2002 Zafra Lerman Cydan Development Inc 1968 Samuel Edward Kamerling & Achillion Pharmaceuticals 2003 David N. Harpp William Campbell Root Alkermes 1969 Joseph Edward Mayer 2004 Richard N. Zare FLAMMA 1970 Hubert Newcombe Alyea 2005 Morton Z. Hoffman Safety Partners Inc Piramal Pharma Solutions’ 1971 Charles Lester Bickel 2006 Brian P. Coppola 2007 Diane M. Bunce Selvita, Inc. 1972 Saul Gerald Cohen Organix 2008 David K. Gosser, Jr.; Jack A. 1973 Eugene George Rochow CreaGen Life Science Kampmeier, Pratihba Varma- 1974 Grant Hopkins Harnest Nelson Entasis Therapeutics 1975 Leonard Kollender Nash Morphic Therapeutic 2009 William F. Polik Interchim, Inc 1976 Malcolm Mackenzie Renfrew 2010 George M. Bodner Xtal Biostructures 1977 Anna Jane Harrison 2011 Peter Mahaffy Quartet Medicine 1978 Paul Doughty Bartlett & Henry 2012 Vicente Talanquer Anton Parr USA C. McBay 2013 Melanie M. Cooper Biotage 1979 Harry Hall Sisler Bioduro 2014 Thomas Greenbowe 1980 Robert C. Brasted Novalix Pharma 2015 Frank J. Creegan, Richard S. Thermo Fisher 1981 Fred Basolo Moog, James Spencer Cresset Group 1982 William Thomas Lippincott 2016 Thomas Holme Custom NMR Services 1983 Bassam Z. Shakhashiri 2017 Marcy H. Townes u 1984 Henry A. Bent 2018 Gerard Parkin

4 The Nucleus November 2018 Monthly Meeting Biography: Gerard Parkin is a Professor of Chem- The 982nd Meeting of the Northeastern Section of the istry at Columbia University, where he was Chair during 1999 – 2002. He has American Chemical Society also served as Chair of the New York Presentation of the 2018 James Flack Norris Award for Section of the American Chemical So- Outstanding Achievement in the Teaching of Chemistry ciety, Chair of the Inorganic Chemistry and Catalytic Science Section of the Thursday, November 15, 2018 New York Academy of Sciences, Chair Simmons University of the Organometallic Subdivision of 300 The Fenway, Boston, MA 02115 the American Chemical Society Divi- The Linda K. Paresky Conference Center, 3rd Floor of the Main College Build- sion of Inorganic Chemistry, and Chair ing of the Gordon Research Conference in Organometallic Chemistry. He is an Agenda: elected Fellow of both the American 4:30 pm NESACS Board Meeting (Room C118, Linda K. Paresky Conference Chemical Society and the Royal Society Center) of Chemistry and is the recipient of a va- rd riety of international awards, including 5:30 pm Social Hour (3 Floor, Paresky Center) the ACS Award in Pure Chemistry, the 6:30 pm Dinner (3rd Floor, Paresky Center) ACS Award in Organometallic Chem- istry, the RSC Corday Morgan Medal, 7:30 pm Presentation of the ACS Award for Volunteer of the Year the RSC Award in Organometallic 7:40 pm Presentation of the 2018 James Flack Norris Award for Excellence Chemistry, the RSC Ludwig Mond in Teaching to Gerard Parkin, Columbia University. Award, and the RSC Chem Soc Rev Title: Beyond Lewis Theory in the Teaching of Inorganic Chemistry. Lecture Award. He is also the recipient of the United States Presidential Award Please join us for our November Monthly meeting to honor the 2018 recipient for Excellence in Science, Mathematics of the James Flack Norris Award. The Award, the first national award for out- continued on page 14 standing achievement in the teaching of chemistry, was established in 1950 by the Northeastern Section of the American Chemical Society to honor the memory of James Flack Norris, Professor of Chemistry at the Massachusetts Institute of Abstract: Technology, and a teacher of great repute. It is awarded for Outstanding Achieve- ment in the Teaching of Chemistry and pays tribute to outstanding contributions Beyond Lewis Theory in to the field of chemical education. We will also be honoring Jennifer Maclachan the Teaching of Inorganic with the Northeastern Section of the ACS 2018 Volunteer of the Year Award. This Chemistry award recognizes one individual annually for demonstrating extraordinary out- Together with simple electron counting reach volunteer service within the section. procedures (e.g. the octet and 18-elec- YOU MUST REGISTER IN ADVANCE TO ATTEND THE MEETING: tron rules), the concept of the 2-center THERE IS NO REGISTRATION FEE 2-electron (2c–2e) bond, and its repre- TO ATTEND THE MEETING; DINNER RESERVATIONS ARE REQUIRED. sentation as a solid black line between PUBLIC IS INVITED two atoms in so-called “Lewis struc- • For those who would like to join us for dinner, register by noon, Thursday, No- tures”, have been of immense impor- vember 8th, at https://norris-award-2018.eventbrite.com tance in the development of chemistry. • Cost: Members, $30; Non-members, $35; Retirees, $20; Students, $10. Dinner However, despite the significance of the reservations not cancelled 24 hours in advance will NOT be refunded (please concept of the 2c–2e bond, its limita- select Meat, Fish or Vegetarian when registering for dinner). Please also indi- tions as a model are well-known, as il- cate whether Parking will be required. lustrated by diborane, which features a 3-center 2-electron (3c–2e). Although • If you wish to join us for this meeting and not eat dinner, please register by the bonding within such molecules may noon, Thursday, November 8th at https://norris-award-2018.eventbrite.com be analyzed by application of either mo- Select “Seminar only”. lecular orbital theory or more sophisti- Please note that Parking will not be reimbursed, but is accessible on Avenue Louis cated theoretical methods, they lack the Pasteur. However, Parking may be limited at this address and other local area u convenience of simple electron counting parking garages may need to be used in the Longwood Area. procedures in evaluating the chemical continued on page 14

The Nucleus November 2018 5 Raj Rajur Receives the 2018 Henry A. Hill Award

Dr. Rajur holds a PhD degree in mentoring and seed funding to start-up synthetic organic chemistry and has en- companies. At the C2I accelerator, he is joyed a distinguished career in the aca- responsible for venture capitalization demic community and the pharmaceuti- and business development. Dr. Rajur has cal industry with a broad range of also co-founded a biometric technology expertise in medicinal chemistry and company “Face pay” which is currently drug discovery fields specifically tar- developing a POC for the technology. geted towards cancer, diabetes and anti- Dr. Rajur serves as the reviewer for the infective therapeutics. He has authored ACS Journal of Medicinal Chemistry and more than 30 papers in peer-reviewed Journal of Pharmaceutical Sciences, he journals and holds several US patents. is on the Board of Directors for Vet On- Dr. Rajur’s academic career includes ap- coRX, Augusta Pharmaceuticals, TME pointments at the Southwestern Medical Therapeutics and co-chair for the Mas- Center in Dallas, Boston College, sachusetts Biotechnology CROCMO u Northeastern University, Massachusetts forum. Raj Rajur received the 2018 Henry A. General Hospital and Harvard Medical Hill Award for Outstanding Service to School. In the industrial sector, he has the Northeastern Section of the Ameri- held scientific and managerial positions can Chemical Society (NESACS) at the at ArQule and Millipore Corporations. October Meeting. The Hill Award was At ArQule, Dr. Rajur supervised collab- created in 1980 to honor the contribu- orations with Bayer, Pfizer and Amer- tions of Henry A. Hill to NESACS and sham Pharmacia Biosciences. Dr. Rajur the American Chemical Society. Henry also significantly contributed to Ar- A. Hill was the first recipient (posthu- Qule’s internal drug discovery pro- mously) of the award. grams, specifically the ion channel, ki- Dr. Raj Rajur has been an active nase and GPCR programs. Products and enthusiastic member of NESACS co-developed by Dr. Rajur have been and a member of the Board of Directors used in drug discovery efforts at VetOn- since 2002. He has been serving as the coRx and Clonetech Laboratories. Program Chair for the Medicinal Chem- Presently, Dr. Rajur heads up istry section of NESACS since 2002. CreaGen Inc as CEO, which he launched During his tenure he has made signifi- in 2003 in order to provide early stage cant changes to format of the sympo- drug discovery services to biotech, phar- sium establishing the signature event maceutical companies and academic in- “Advances in Chemical Sciences Sym- stitutes. Since its inception he grew posium Series”, that continues to attract CreaGen from a one-person company to more than 400 attendees annually. He its current 20 people organization. He has also regularly represented NESACS has established more than 50 strategic at the National ACS meetings and par- alliances with pharmaceutical, biotech- ticipated in its governance meetings. Dr. nology companies and Federal research Rajur remains a keen participant in the laboratories. ACS Department of Career Services, With over 25 years of experience in mentoring and coaching ACS members biotechnology management and entre- at the national meetings. His vision for preneurial ventures involving Drug dis- Med Chem group remains bringing in covery he helped launch CreaGen Life Q. Exactly, how many awards and top notch science to the symposia and to Science Incubator in 2013, a division of scholarships does NESACS sponsor? help drive the establishment of a Medic- CreaGen that provides infrastructure inal Chemistry prize which would en- and instrumentation to early stage com- A) One b) Two c) Many able the recognition of an important panies to conduct their proof of concept. www.nesacs.org/awards local medicinal chemist annually at the In 2017, the life science incubator was May symposium. rebranded as C2I Accelerator to provide

6 The Nucleus November 2018 American Chemical Society 256th ACS National Meeting Boston, Massachusetts August 19-23, 2018

Councilor Talking Points: Richard S. Danchik 92 Summary of Governance Issues and Actions *Jacqueline A. Erickson 217 Rick Ewing 176 The following summary is provided to help Councilors report *Judith M. Iriarte-Gross 214 to their Local Sections and Divisions on key actions of the Russell W. Johnson 114 ACS Council meeting held August 22, 2018, and the Board of *Donivan R. Porterfield 206 Directors meetings held August 17-19, 2018, at the 2018 ACS *Carolyn Ribes 328 fall national meeting in Boston, Massachusetts. Full reports Frank Romano 171 are posted on the ACS Website as they become available. Peter Zarras 119 Actions of the Council Other Council Actions Election Results: Elected Committees of Council Amendments to the ACS Bylaws • By electronic ballot, the Council elected Ella L. Davis, A recommendation by the Committee on Membership Lissa A. Dulany, Lisa Houston, and Martin D. Rudd for Affairs that Council approve the Petition on International three-year terms (2019-2021), and Will E. Lynch for a one- Chemical Sciences Chapters achieved the two-thirds majority year term (2019) on the Council Policy Committee (CPC). required to amend Bylaw XI, Section 3 accordingly (additions Lawrence J. Berliner 103 underlined; deletions struck through): Michelle V. Buchanan 185 Affiliations of SOCIETY Local Sections or Divisions Alan B. Cooper 191 shall become effective upon authorization by their governing *Ella L. Davis 196 body, approval by their respective Council committees gov- *Lissa A. Dulany 201 erning Local Sections and Divisions, and by confirmation by Lydia E. M. Hines 194 the Council Committee on Constitution and Bylaws acting for *Lisa Houston 231 the Council, that the provisions of Section 1 of this Bylaw are *Will E. Lynch 195 met. *Martin D. Rudd 220 The changes will become effective upon confirmation by Barbara P. Sitzman 163 the Board of Directors. • By electronic ballot, the Council elected Allison Aldridge, A recommendation by the Committee on Membership Christopher J. Bannochie, Mary K. Engelman, Silvia Affairs that Council approve the Petition on International Ronco, and Frankie K. Wood-Black for three-year terms Chemical Sciences Chapters achieved the two-thirds majority (2019-2021) on the Committee on Nominations and Elec- required to amend Bylaw IX, Section 4 accordingly (additions tions (N&E). underlined; deletions struck through): *Allison Aldridge 216 An International Chemical Sciences Chapter shall receive *Christopher J. Bannochie 228 no allotment of funds from the SOCIETY and shall not be en- *Mary K. Engelman 222 titled to elected representation on the Council. A Chapter may Kenneth P. Fivizzani 162 assess its members local Chapter dues to be expended for its Anne M. Gaffney 187 own purposes in harmony with the objects of the SOCIETY. David S. Gottfried 136 The changes will become effective upon confirmation by James M. Landis 189 the Board of Directors. R. Daniel Libby 135 Continuation of Committee *Silvia Ronco 206 On the recommendation of the Committee on Committees, *Frankie K. Wood-Black 220 and the concurrence of the Council Policy Committee, Coun- • By electronic ballot, the Council elected Rodney M. Ben- cil approved the continuation of the Committee on Chemical nett, Jacqueline A. Erickson, Judith M. Iriarte-Gross, Safety, subject to concurrence by the Board of Directors. Donivan R. Porterfield, and Carolyn Ribes for three-year Resolutions terms (2019-2021) on the Committee on Committees The Council passed resolutions (ConC). *Rodney M. Bennett 189 • in memory of deceased Councilors; continued on page 8

The Nucleus November 2018 7 National Meeting Very Familiar 38% (157) Continued from page 7 Vaguely Familiar 46% (192) Not Familiar 16% (68) • congratulating ACS Treasurer and Chief Financial Officer Brian A. Bernstein on the occasion of his retirement after Has your local section or division instituted a sexual harass- nearly 40 years of service to the Society (34 as ACS Treas- ment policy of its own? (419 responses) urer); Yes 3% (12) • in gratitude for the officers and members of the Northeast- No 73% (309) ern Section, host Section for the 256th National Meeting, Don’t Know 23% (98) the divisional program chairs and symposium organizers, Highlights from Committee Reports and ACS staff; and Nominations and Elections • acknowledging Peter K. Dorhout’s service as ACS Presi- The Committee on Nominations and Elections solicits Coun- dent and presiding officer of the Council. cilors’ input of qualified individuals for President-Elect and/or Special Discussion Directors for future consideration. Suggestions can be sent to President Dorhout introduced and led a special discussion on [email protected]. what role(s) ACS should play in preventing sexual harassment Ballots for the 2018 fall national election will be distrib- in the sciences. He highlighted several recent articles, work- uted October 1-3, with a voting deadline four weeks later, on shops and studies that have called attention to the issue, no- October 31. ACS members eligible to vote and with an email tably a symposium, “Science of Sexual Harassment” address on file will receive an electronic ballot with the option organized during the ACS National Meeting in New Orleans to request a paper ballot. Those members with no email ad- (Spring 2018) by the Women Chemists Committee and Chem- dress on file will be sent a paper ballot but with the option to ical & Engineering News; and a National Academies of Sci- vote electronically. The ACS election vendor, Survey & Ballot ences, Engineering, and Medicine consensus study report: Systems, will send three email reminders during the voting “Sexual Harassment of Women: Climate, Culture, and Con- period to those who have not voted as of the reminder date. sequences in Academic Sciences, Engineering, and Medicine” Budget and Finance (2018). He directed Council’s attention to existing ACS codes The Society’s 2018 Probable 1 Projection calls for a Net from and initiatives to address sexual harassment, and offered items Operations of $31.8 million. This is $1.3 million favorable to for discussion and possible action: the Approved Budget. Total revenues are projected to be • More signs/information at National Meetings regarding our $565.1 million, which is $5.7 million or 1.0% favorable to the policies and supporting information Budget. Total expenses are projected at $553.3 million, which • Trained volunteers at national meetings for reporting sexual is $4.4 million or 0.8% unfavorable to the Budget. harassment The Committee considered one 2019 program funding reauthorization request, and on its recommendation, the Board • A webinar on preventing sexual harassment for local sec- subsequently approved funding the ACS Festival Series for tions or divisions inclusion in the 2019 Proposed Budget and the 2020-2021 To further inform the discussion and Councilor input, a brief Forecast Budgets. survey was conducted using the audience electronic response The Society is expected to end the year in compliance system. The results of the survey are listed below. The ACS with each of the five Board-established financial guidelines. Volunteer/National Meeting Attendee Conduct Policy was in Additional information can be found at www.acs.org, at the the Council Agenda, and can be found online at [http://www. bottom of the page, click ‘About ACS’, then ‘Financial’. acs.org/content/acs/en/about/governance/councilors.html] A Boston Meeting Attendance summary of the discussion and additional information will be The theme of the 256th ACS National Meeting was sent to Councilors at a later time. “Nanoscience, Nanotechnology, and Beyond.” As of Tuesday Have you ever witnessed or experienced sexual harassment evening, August 21, attendance was: at an ACS meeting or ACS event? (413 responses) Attendees 8294 Yes 23% (94) No 77% (319) Students 3671 Have you ever witnessed or experienced sexual harassment Exhibitors 1181 at an ACS meeting or ACS event, or in your professional Expo only 576 workplace or learning environment? (182 women / 223 men Guest 513 responded) Total 14,235 Women Men Membership Affairs Yes 77% (141) 57% (127) As of August 21, ACS had 149,584 members, which is a de- No 23% (41) 43% (96) cline of only eight-tenths of one percent from the over 150,000 members in 2017. This year-to-date figure represents an in- How familiar are you with the ACS Codes and initiatives for crease of over 1,200 members when compared to the last two professional conduct? (417 responses) continued on page 9

8 The Nucleus November 2018 National Meeting • The Board’s Society Programs global liaison offered an up- date on efforts to strengthen the global presence of Society Continued from page 8 programs to better serve our international members and the years. It was noted that five of last seven months have been global chemistry enterprise. Efforts are underway to clarify respectively the best months for membership since at least and articulate the current state of international activities, 2014. The current membership count positions ACS for a products, and services; to clarify the challenges associated strong close to the year, and there is cautious optimism that with globalization of existing domestic activities; and to total membership will rise for the first time since 2011. offer recommendations for moving forward. Next steps in- Petitions to Amend the Constitution and Bylaws clude interviewing key stakeholders, reviewing past efforts, New petitions to amend the Constitution or Bylaws must be and exploiting existing market research with a view toward received by the Executive Director & CEO no later than De- developing a strategic plan, activities, and timelines for cember 12 to be included in the Council agenda for consider- Board consideration. ation at the spring 2019 meeting in Orlando. Contact the • The Board liaison to the Leadership Advisory Board (LAB) Committee on Constitution and Bylaws with any questions or provided an update on initial efforts geared towards the de- requests for information at [email protected] velopment of a next-generation ACS Leadership Program. Actions of the Board of Directors A small task force has been charged with investigating the The Board’s Executive Session state of the art in leadership development, assessing the fu- At this meeting, the ACS Board of Directors focused on a ture needs of the Society as well as those of individual number of key strategic issues and took several related ac- members and their employers, and then proposing, by the tions. end of 2019, a strategic vision for and the specifications of a next-generation ACS leadership program focused on 2030 The Board’s Committees and beyond. The Board of Directors received and discussed reports from its committees on Corporation Associates, Professional and Executive Director and CEO Report Member Relations, Executive Compensation, the Governing The Board also received an extensive report from the Execu- Board for Publishing, and the Society Committee on Budget tive Director and CEO on issues relating to Passion for Chem- and Finance. On the basis of those reports and with regard to istry and Diversity and Inclusion as core values of the Society, the Board’s strategic vision for the Society: on Membership, ACS financial performance, and upcoming events and activities. He reported there has been initial success • The Board approved, on the recommendation of the Com- with several initiatives underway to address and reverse the mittee on Professional and Member Relations, the Society’s decline in membership. His direct reports provided updates to nominees for the 2019 Perkin Medal and the 2019 National the Board on the activities of Chemical Abstracts Service Science Board Public Service Award. (CAS), the ACS Publications Division, and the Office of the • The Board voted to approve the appointments or reappoint- Secretary and General Counsel. As part of his report, he also ments of several editors-in-chief for ACS journals as rec- invited the Executive Vice President for Human Resources to ommended by the Joint Board-Council Committee on brief the Board on the activities, opportunities and challenges Publications and Editor Selection Committees. Information of the Human Resources Division. about those appointments will appear in C&EN once the in- dividuals concerned have been notified. Other Society Business The Board approved the foundation documents of the newly • In light of the recent financial performance of the techni- created endowment for the Henry H. Storch Award in Energy cal-meeting component of our national meetings, the Board Chemistry, which originally was established as a national voted to approve an advance member registration fee of award in 1964. only $490 for national meetings held in 2019 (i.e., the cur- As is customary, the Board heard reports from members rent advance member registration fee escalated to account of the Presidential Succession on their current and planned for inflation only); to reauthorize a program funding request activities for 2018-2019. Several presidential symposia and for the Chemistry Festival program; and in accordance with events incorporating and supporting this national meeting’s past practice, to allocate on a pro-rated basis to qualified theme of “Nanoscience, Nanotechnology & Beyond” were ACS Divisions any net revenues accrued to the Society highlighted in those reports. from the 2020 and future International Chemical Con- gresses of the Pacific Basin Societies (Pacifichem). The Board’s Regular Session • The Board liaison to the Committee on Corporation Asso- The Board held a well-attended regular session on Sunday, ciates presented a proposed committee Future State Oper- August 19, that featured a presentation by Nobel Laureate Sir ating Model and considered options for committee member Fraser Stoddart who spoke on transformative research and re- terms and appointment processes. The Board expressed viewed his contributions in supramolecular chemistry and mo- support for the value of industry to ACS and acknowledged lecular recognition. Also, as a Champion of the program, he Corporation Associates as being positioned within the Soci- advocated for ACS Project SEED on the 50th Anniversary of ety to represent the voice of industry to the Board and ACS. the program. Prior to the presentation, members of the presi- photos continued on page 14

The Nucleus November 2018 9 September 2018 Monthly Meeting

By Mindy Levine, 2018 Chair, Northeastern Section of the American Chemical Society, Photos by Brian D’Amico. On September 20, 2018, the monthly meeting of the North- SACS board for coordinating this important effort. eastern Section of the American Chemical Society took place. After the tour of the archives and the social hour, the This meeting was held at Salem State University, in Salem, meeting continued with recognizing 50-, 60-, and 70-year MA, and one of the goals of the meeting was to be able to members of the Section. We are particularly honored to have view the archives of the Section, currently housed in the recognized Dr. Merrill Cohen, a World War II veteran and 70- Salem State University library. Several members of the NE- year member of ACS. Finally, the keynote speaker of the SACS board took advantage of this opportunity to view im- evening, Sam Kean, delivered a highly engaging lecture, in portant archives, including notes from the first meeting, which he mentioned several of the books he has authored. brochures and pamphlets from previous Section events, and Many of the books were available for sale after the lecture. photos of key contributors to this important section. Many We are thrilled so many members came out for this meet- thanks to Susan Edwards of Salem State University who con- ing, and look forward to more exciting monthly meetings and u tinues to care for these archives, and to Ken Mattes of the NE- events! continued on page 11

2018 NESACS Chair, Mindy Levine, introduces Sam Kean, Science writer Sam Kean delivering his keynote address about his book of stories about and the meeting’s keynote speaker. the periodic table: “The Disappearing Spoon”.

60-year member Alice Joan Adler with NESACS Program Chair Andrew 70-year member Merrill Cohen with NESACS Program Chair Andrew Scholte and Mindy Levine. Scholte and Mindy Levine.

10 The Nucleus November 2018 September 2018 Monthly Meeting

Continued from page 10

60-year member William Eykamp 60-year member John T. Penniston

50-year member Eugene Barry Wilusz 50-year member Glen Ernest Rodgers

50-year member Anthony P. Wright 50-year member Joseph Eugene Lester

The Nucleus November 2018 11 Photos from the 2018 GDCh-NSYCC Exchange - Boston Photos by Brian D'Amico

Participants in the 18th exchange between the NESACS Younger Chemists Committee (NSYCC) and their German counterpart from the GDCh.

The German visitors and their hosts from NESACS enjoyed a full range of activities including a visit to Cape Cod on Thursday. The trip to the Cape in- cluded a visit to Woods Hole Oceanographic Institute, a clambake at Goodwill Park and a beach outing at Surf Drive Beach. Other activities included a Welcome Dinner on Saturday, A Sunday social mixer with the National YCC at the Back Bay Social Club, A Monday night gathering at Harpoon Brew- ery, a Red Sox game on Wednesday, and a Farewell Dinner and Boston Harbor Cruise on the Odyssey. continued on page 13

12 The Nucleus November 2018 2018 GDCH-NSYCC Exchange

Continued from page 12

At the Monday gathering at the Harpoon Brewery. The group pays close attention to a presentation on Underwater Robotics at the Woods Hole Oceanographic Institute.

Jens Breffke in discussion with our guests prior to the welcome dinner. Enjoying the social hour on the Odyssey prior to the farewell dinner.

Part of the discussion at the Back Bay Social Club with the National YCC. The Farewell Dinner on the Odyssey.

The Nucleus November 2018 13 National Meeting Biography Medicinal Continued from page 9 Continued from page 5

dential succession and the Executive Di- and Engineering Mentoring, the United Chemistry rector & CEO offered brief reports on States Presidential Faculty Fellowship their activities. The officers provided Award, the Columbia University Presi- Group Hosts more extensive reports on their activities dential Award for Outstanding Teaching, and future plans as part of their written and the Lenfest Distinguished Columbia ◆ and oral reports to the Council. Faculty Award. Symposium SUPPLEMENTAL INFORMA- TION FOR COUNCILORS on The Officers: Abstract Continued from page 5 Peter K. Dorhout, President, Future of [email protected] reasonableness of a covalent molecule. Bonnie A. Charpentier, Fortunately, approaches for analyzing Anti- President-Elect, complex covalent molecules in a simple [email protected] way are available, and their use in the application in the Covalent Bond Clas- Allison A. Campbell, Infectives sification of molecules will be dis- Immediate Past President, ◆ cussed. by Mindy Levine [email protected] On Thursday September 13, 2018, ap- proximately 70 medicinal chemists (and Online Information for Councilors othe http://www.acs.org/content/acs/en/about r chemists interested in medicinal /governance/councilors.html THE COMMITTEE ON chemistry) gathered together at Takeda Councilor Talking Points is produced by CHEMICAL ABSTRACTS Pharmaceuticals for a half-day sympo- the ACS Office of the Secretary & Gen- (CCAS) WANTS YOUR sium on the topic of “The Future of eral Counsel Anti-infectives.” This symposium was Permission is hereby granted to distrib- FEEDBACK sponsored by Takeda Pharmaceuticals ute in whole or part. Visit our page on ACS Network: and was organized by the Medicinal Please direct all comments and ques- ◆ https://communities.acs.org/groups/ Chemistry Group of the Northeastern tions to: [email protected] Section of the American Chemical So- chemical-abstracts-service-committee ciety. The medicinal chemistry group, or contact Michael Filosa with any organized by Dr. Raj Rajur of Creagen suggestions at [email protected] Bio and Dr. Andrew Scholte of Sanofi, lowed by the plenary evening lecture hosts half-day symposia twice a year, in presented by Jacques Dumas of September and in December, at a variety Tetraphase. The title of the talk was of pharmaceutical companies through- “TP-6076: taking chemistry to the next out the greater Boston area. level to beat superbug.” The full speaker lineup for the Sep- Overall, the attendees had uni- Looking for seminars tember event is shown below: formly positive things to say about the in the Boston area? Afternoon speakers: symposium, with attendees highlighting • Kim Lewis, Northeastern University, the timeliness of the topic, the relevance Check out the Title: Reviving Antibiotic Discovery to their careers, and the important net- from Natural Products working opportunities provided through NESACS Calendar • Thomas Durand Reville, Entasis, attending these symposia. www.nesacs.org/seminars Title: The rational design and discov- Stay tuned for the next medicinal ery of ETX2514, a novel broad-spec- chemistry symposium, coming in De- ◆ trum β-lactamase inhibitor for the cember 2018! treatment of Gram-negative infections The NESACS website • Roger Clark, Macrolide, Title: Novel Macrolides for Gram-Negative Infec- Updated frequently • Late-breaking news • position postings tions Back issues of the Nucleus archived • Career-related Links • Awards and Scholarships After the afternoon speakers, there was WWW.NESACS.org a break for social hour and dinner, fol-

14 The Nucleus November 2018 BUSINESS DIRECTORY SERVICES SERVICES SERVICES

What’s Yours? Many local employers post positions on the NESACS job board. Find yours at www.nesacs.org/jobs

Join NESACS on facebook www.facebook.com/nesacs

Your source to career-related links WWW.NESACS.ORG/CAREERS

Index of Advertisers

Eastern Scientific Co...... 16 Micron, Inc...... 15 Organix, Inc...... 15 PCI Synthesis...... 15 Robertson Microlit Labs..15

The Nucleus November 2018 15 Medfield, MA 02052 18 Tamarack Road AMERICAN CHEMICAL U.S. POSTAGE PAID NONPROFIT ORG. NORTHEASTERN SOCIETY SECTION

November 05 November 15 Calendar Prof. Eric Hudson (UCLA) Prof. Bingjun Xu (Delaware) Harvard, Pfizer Lecture Hall, 4:15 pm Boston College, Merkert 130, 4:00 pm Check the NESACS home page Prof. Ursula Jakob (Michigan) November 19 MIT, 4-270, 4:00pm for late Calendar additions: Prof. Amie K. Boal (Penn State) http://www.NESACS.org Prof. Katherine Mirica (Dartmouth) “Watching Metalloenzymes at Work” Brandeis, Gerstenzang 121, 3:40 pm MIT, 4-270, 4:00 pm Note also the Chemistry Department web Prof. Yisong Guo (Carnegie Mellon) Prof. Lasse Jensen (Penn State) pages for travel directions and updates. Boston Univ., Metcalf 113, 4:00 pm Boston Univ., Metcalf 113, 4:00 pm These include: November 06 November 20 http://www.bc.edu/schools/cas/chemistry/s eminars.html Prof. Neil Garg (UCLA) Prof. Wayne Jones (UNH) http://www.bu.edu/chemistry/seminars/ Boston College, Merkert 130, 4:00 pm Univ. New Hampshire, Parsons N104, 11:10 am http://www.brandeis.edu/departments/chem Prof. Thomas Mallouk (Penn State) Prof. Sachdev Sidhu (Toronto) istry/events/index.html “Managing Electrons and Protons in the Bio- Tufts, Pearson, P-106, 4:30 pm http://chemistry.harvard.edu/calendar/upco Inspired Production of Fuel from Sunlight” November 27 ming Univ. New Hampshire, Parsons N104, 11:10 am http://www.northeastern.edu/cos/chemistry/ Prof. Rob Spitale (UCal-Irvine) Prof. Jacob Shelley (RPI) events-2/ Tufts, Pearson P-106, 4:30 pm Univ. New Hampshire, Parsons N104, 11:10 am http://chemistry.mit.edu/events/all November 07 Prof. Adriaan Bax (NIH) http://chem.tufts.edu/seminars.html “Opportunities and challenges of pressure-jump http://engineering.tufts.edu/chbe/newsEven Prof. John Matson (Virginia Tech) NMR spectroscopy in the study of protein ts/seminarSeries/index.asp Boston College, Merkert 130, 4:00 pm folding” http://www.chem.umb.edu Prof. Smaranda C. Marinescu (USC) MIT, 6-120, 4:00 pm http://www.umassd.edu/cas/chemistry/ MIT, 4-370, 4:15 pm November 28 November 12 http://www.uml.edu/Sciences/chemistry/Se Professor Peng Yin, Harvard University minars-and-Colloquia.aspx Prof. Raymond Schaak (Penn State) Boston College, Merkert 130, 4:00 pm http://www.unh.edu/chemistry/events Boston Univ., Metcalf 113, 4:00 pm https://www.wpi.edu/academics/departmen Prof. Serena DeBeer (Max Planck) ts/chemistry-biochemistry November 13 Harvard, Pfizer, 4:15 pm November 01 Prof. Robert Knowles, (Princeton) Prof. Kristi Kiick (Delaware) Boston College, Merkert 130, 4:00 pm “Biopolymeric Conjugates in the Production of Novartis Lecture in Organic Chemistry Responsive Biomaterials” Prof. Shankar Balasubramanian (Cambridge) & November 14 WPI, Goddard 227, 12:00 noon Dr. Chris Gampe (Novartis) Prof. Mohammad Seyedsayamdost, (Princeton) Notices for The Nucleus “The Ends Justify the Means: Tweaking mRNA Boston College, Merkert 130, 4:00 pm Properties” Calendar of Seminars should be MIT, 6-120, 4:00 pm Prof. Brandi Cossairt (Washington) sent to: November 02 Harvard, Pfizer Lecture Hall, 4:15 pm Prof. William Epling (Virginia) Michael Filosa, email: u Prof. Tom Baker (University of Ottawa) Sulfur Oxidation over Automotive Catalysts [email protected] Boston College, Merkert 130, 4:00 pm WPI, Goddard 127, 12:00 noon