<<

ANNUAL REPORT

2007

Northeastern Section American Chemical Society

Local Section Name: Northeastern Section URL for Total Report: http://www.nesacs.org

Dr. Mukund S. Chorghade Chair 2007 Northeastern Section, ACS

2 TABLE OF CONTENTS

PART I - QUESTIONNAIRE

Annual Report Questionnaire...... 6

PART II: ANNUAL NARRATIVE REPORT

Activities: Activity 1 Advances in Chemical Sciences Symposium...... 17 Activity 2 Fostering Interactions with Chemical Societies...... 17 Activity 3 Refining Career Services Events...... 17 Activity 4 Science Cafes organized by Speakers’ Bureau ...... 18 Activity 5 Education Events organized by Education Committee ...... 18 Activity 6 NCW Event at Museum of Science Boston ...... 19 Activity 7 Organization of Science Club at Natick High School ...... 19 Activity 8 Ongoing Collaboration with GDCh & Symposium ...... 20 Activity 9 Formation of special Government Affairs Committee ...... 21 Activity 10 Networking & Fund-raising events / Golf Tournament ...... 21 Summary ...... 21 2007 Goal Attainment 2007 Local Section Goals and Assessment ...... 22 2007 Chair's Goals and Assessment\...... 23 2008 Goals...... 24

PART II - APPENDICES 1-5

APPENDIX 1 - SUPPORTING DOCUMENTS FOR ACTIVITIES

Supporting Documents for Activities Activity 1 Advances in Chemical Sciences Symposium...... 26 Activity 2 Fostering Interactions with Chemical Societies...... 28 Activity 3 Refining Career Services Events...... 29 Activity 4 Science Cafes organized by Speakers’ Bureau ...... 31 Activity 5 Education Events organized by Education Committee ...... 34 Activity 6 NCW Event at Museum of Science Boston ...... 37 Activity 7 Organization of Science Club at Natick High School ...... 39 Activity 8 Ongoing Collaboration with GDCh & Symposium ...... 41 Activity 9 Formation of Special Government Affairs Committee...... 45 Activity 10 Networking & Fund-raising events / Golf Tournament ...... 47

APPENDIX 2 - BUDGETS AND LONG-RANGE PLAN

2-A: Budget for 2007...... 52 Budget for 2008...... 54 2-B: Long-Range Plan...... 55

APPENDIX 3 - MEMBERSHIP SURVEYS AND 2007 NEWSLETTER

3-A: Membership Survey Conducted in 2007 - No survey conducted in 2007...... 57 3-B: 2007 Newsletter...... 57 Summer 2007 issue of The Nucleus uploaded to ACS online report (S.O.L.A.R.)

APPENDIX 4 - PUBLIC RELATIONS PLAN - TALKS TO PUBLIC - NEWSPAPER CLIPPINGS

4-A: Public Relations Plan - No plan prepared for 2007...... 58 4-B: Talks to Public...... 59 4-C: Press Releases: None available

3

APPENDIX 5 - AS NEEDED BY SECTION: NESACS REPORTS

Officers, Councilors, Directors, and Committee Chairs 2007...... 64 Calendar of Activities 2007...... 71 Reports: Archivist...... 73 Awards Committee...... 74 Awards Presented by the Northeastern Section...... 80 Brauner, Phyllis A. - Memorial Lecture...... 82 Constitution & Bulaws ...... 83 Continuing Education Committee...... 84 Education Committee...... 84 Education Committee / High School Subcommittee ...... 96 Esselen Award Committee...... 110 Fund-raising Committee...... 123 Government Relations Committee ...... 127 Local Arrangements Committee ...... 128 Medicinal Group...... 129 Membership Committee...... 136 National Chemistry Week Committee...... 138 National Meeting Planning Committee...... 140 Nominating Committee ...... 147 Norris Award Committee...... 148 Professional Relations Committee...... 157 Program Committee / Chair-Elect ...... 160 Publications, Board of ...... 163 Richards Medal Committee...... 166 Speakers' Bureau...... 169 Summerthing 2007 ...... 174 Treasurer and Auditor ...... 175 Trustees, Board of ...... 177

APPENDIX 5-A; SPECIAL PROGRAMS / web pages

Northeast Student Chemistry Research Conference (NSCRC) - YCC web site ...... 179 Undergraduate Research Symposium at Bridgewater State College - BSC web site...... 181

APPENDIX 6 - YOUNGER CHEMISTS COMMITTEE

Report of the Younger Chemists Committee...... 183

PART III - ANNUAL FINANCIAL REPORT

Part A: Statement of Revenues and Expenses Operating Fund...... 195 Part B: Balance Sheet as of 12/31/07...... 196

PART IV - SELF-NOMINATIONS FOR CHEMLUMINARY AWARDS

Outstanding Performance by Local Sections ...... 199 Most Innovative New Activity or Program in a Local Section...... 202 Best Activity or Program in a Local Section Stimulating Membership Involvement...... 203 Outstanding Local Section Career Programs...... 205 Outstanding or Creative Local Section Younger Chemists Committee Event ...... 207 Outstanding Event for a Specific Audience - NCW...... 209 Best High School Event...... 213

4

ANNUAL REPORT Northeastern Section, ACS

PART I

QUESTIONNAIRE

http://www.nesacs.org

5

American Chemical Society

Form: Part I - Annual Report Questionnaire REQUIRED Organization: Northeastern Year: 2007

****Important Notice Please Read****

The EZ form consists of the Part I - Questionnaire, Part III - Financial Report and the Optional Part IV - Self-Nomination Form for ChemLuminary Awards. Sections that wish to submit the EZ form are not required to submit the Part II - Narrative and Appendices. All local sections are eligible to complete the EZ form UNLESS, they would like to self-nominate themselves for the LSAC Award for Outstanding Performance by a Local Section. Local sections may submit the EZ form and self-nominate themselves for any of the other awards listed in Part IV. Local Sections must postmark or submit their completed annual reports electronically by February 15, 2008 to be eligible for any of the awards.

We do not wish to be considered for the Local Section Outstanding Performance Award

*Part I Annual Report Questionnaire *Part II Annual Report Narrative and Appendices (Optional) *Part III Financial Report *Part IV Self Nomination for ChemLuminary Awards (Not Eligible for Local Section Outstanding Performance Award (Optional)

Our section would like to be considered for the ACS Local Section Outstanding Performance Award. We are submitting Parts I,II,III and IV of the annual report

*Part I Annual Report Questionnaire * Part II Annual Report Narrative and Appendices * Part III Financial Report * Part IV Self Nomination for ChemLuminary Awards (***Outstanding Performance Award Nomination must be completed***)

Web Posting of Annual Reports

Our Section would like to have Parts I and II (if applicable) posted on the Local Section Activities Committee website.

1. TOP ACTIVITIES

Please list the titles of your top activities (Rank order) and indicate if the activity was new in 2007. Check if new in 2007 Title of Activity

1. x Advances in Chemical Sciences Symposium

2. x Fostering Interactions with Chemical Societies

6

3. x Refining Career Services Events

4. x Science Cafes organized by Speakers’ Bureau

5. Evucation Events organized by Education Committee

6. NCW Event at Museum of Science Boston

7. x Organization of Science Café at Natick High School

8. x Ongoing Collaboration with GDCh & Symposium

9. x Formation of special Government Affairs Committee

10. Networking & Fund-raising events / Golf Tournament

2. SECTION ADMINISTRATION

EXECUTIVE COMMITTEE

10 2.1 How many times did the executive committee meet during 2007?

62 2.2 How many members are on the executive committee?

9 2.3 How many section meetings were held in 2007?

62 2.4 On average, how many members attend a regular section meetings? COUNCILORS

100 2.5 What percentage of the section's Councilors were in official attendance at the ACS spring Council meeting? %

100 2.6 What percentage of the section’s Councilors were in official attendance at the ACS fall Council meeting? % 2.7 How do Councilors report to the section about national ACS matters? (check all that apply)

at a section meeting at an executive committee meeting

in the newsletter on the local section website COMMITTEES 2.8 Specify active committees having two or more members. Please indicate the chair's name where appropriate.

Awards Mentoring

Chair: Michael Dube Chair:

Budgets/Finance Minority Affairs

Chair: James U. Piper Chair:

Career Assistance/Employment Newsletter/Publication

7 Chair: Mukund S. Chorghade Chair: Vivian Walworth

Chemistry Olympiad Nominations

Chair: Stephen Lantos Chair: Patricia A. Mabrouk

Community Activities (e.g. National Chemistry Week or Chemists Celebrate Earth Day, etc.) Professional Relations

Chair: Chris Jaworek-Lopes Chair: Mukund S. Chorghade

Continuing Education Project SEED

Chair: Alfred Viola Chair: Patricia A. Mabrouk

Education Public Relations

Chair: Ruth Tanner Chair:

Environmental Senior Chemists

Chair: Chair: Charles Bardsley

Environmental Health & Safety/ Chemical Hygiene Women Chemists

Chair: Chair:

Government Affairs Younger Chemists

Chair: Doris I. Lewis Chair: Laila Dafik

Other: Local Arrangements Industry Relations Chair: Dorothy J. Phillips Chair: Mary Burgess

Other: Constitution & Bylaws Long-Range Planning Chair: Mukund S. Chorghade Chair: Catherine Costello

Other: National Meeting - Boston Membership/Member Retention Chair: Michaeline Chen Chair: Robert Lichter

Other: Programs

Chair: Marietta Schwartz

SUBSECTIONS

0 2.9 How many subsections are active in the section?

0 2.10 How many subsection meetings were held in 2007? TOPICAL GROUPS

1 2.11 How many topical groups are active in the section?

3 2.12 How many topical group meetings were held in 2007? OPERATIONS AND PLANNING (check all that apply)

2.13 The section prepared a budget for 2007 (Please include a copy in Part II Appendix 2)

8 2.14 The section prepared a budget for 2008 (Please include a copy in Part II, Appendix 2) 2.15 The section prepared a long-range plan (Please include a copy in Part II, Appendix 2) 2.16 The section maintains and uses a current job manual prepared by the section as a guide for officers and committees. The section conducted a membership survey in 2007 to determine member's interests and needs (Please include a copy in 2.17 Part II, Appendix 3) 2.18 A section representative attended the ACS Leaders Conference (Local Section Leaders Track) in 2007. 2.19 The section has a succession plan. SECTION COMMUNICATION

10 2.20 How many newsletters were published in 2007? 2.21 One copy of a newsletter is included in Appendix 3.

45 2.22 How many meeting notices were published in 2007? a. URL: www.nesacs.org 2.23 The section has an active website. b. Webmaster Name: David Cunningham

c. email: [email protected]

2.24 The section used electronic communication. 2.25 The section posted its 2006 Annual Report on its website. SECTION ELECTIONS

2.26 The section conducted a 2007 officer election.

2.27 The section conducted its 2007 elections electronically.

2.28 The section revised its bylaws to allow electronic elections

451 2.29 How many members voted in the 2007 officer election? 2.30 How many 2007 elected officials, councilors and committee chairs:

13 a. have held other elected positions in the local section

12 b. have held other appointed positions in the local section

7 c. presently hold more than one elected office

7 d. are in their first two years of service

2.31 For each election that was held in 2007 please give the number of members that ran for:

1 a. Chair-elect

1 b. Secretary

0 c. Treasurer

d. Other (not including councilor) NomCom-Esselen-Richa 14

9

2.32 For the positions of Councilor and Alternate Councilor, did your Yes No local section vote for a single list of Councilor/Alternate Councilors candidates with the highest vote getters being elected as Councilor and those with the next highest vote counts being elected Alternate Councilor?

4 2.33 How many total Councilor positions were available for 2007?

4 2.34 How many total Alternate Councilor positions were available for 2007?

4 2.35 How many Councilor positions were filled in 2007?

4 2.36 How many total Alternate Councilor position were filled in 2007?

9 2.37 How many candidates were on the 2007 ballot for the available Councilor positions?

9 2.38 How many candidates were on the 2007 ballot for the available Alternate Councilor positions?

9 2.39 What was the total number of candidates for Councilor and Alternate Councilor in 2007? SECTION AWARDS (check all that apply)

2.40 The section submitted a nomination for the ACS Regional Award in High School Chemistry Teaching during 2007.

The section gave awards or a Salutes to Excellence to:

2.41 Primary school students (K-6)

2.42 Secondary school students (7-12)

2.43 College students

2.44 Primary school teachers (K-6)

2.45 Secondary school teachers (7-12)

2.46 College teachers

2.47 Members of the local section for service

2.48 Outstanding chemist(s), regardless of section affiliation

2.49 The section or local company encouraged and/or submitted a nomination for the ACS Regional Industrial Innovation Awards. SECTION AFFILIATES How many paid section affiliates excluding students (teachers, technicians, others) are there in the 15 2.50 section? 2.51 Section has supported an existing Technician Affiliate Group (TAG)during 2007. 2.52 Section has promoted the formation of a Technician Affiliate Group during 2007. REGIONAL MEETINGS

2.53 Does your local section have a representative to your Regional Board/Steering Committee? 2.54 Does your section participate in the Regional Chmemjobs Employment Center? VOLUNTEERS

250 2.55

10 Please indicate the approximate number of active volunteers in your local section. (Volunteer is defined as a member who helps plan or organizes a meeting or activity, serves on a committee, or is an elected official including Councilor and Alternate Councilor.)

120 a. How many of these volunteers were new in 2007?

Please indicate all the ways that you recognize 2.56 volunteers:

Certificates Gifts

Awards Letter to volunteer

Letter to volunteer's supervisor Recognition at an event

Other: No formal recognition program

2.57 How does your local section identify future leaders and get them into the leadership pipeline?

Self-Nominations Solicitation or advertising

Identify active committee members Formal leadership training

Outreach to new members Arm-Twisting

Other:

2.58 Aside from the Chair-Elect becoming Chair, does your local section have a long-term plan for developing new leaders and/or volunteers? Yes No 2.59 Does your local section support travel of members (other than councilors) to:

National meetings Regional meetings

NEACT & German Group Leaders Conferences Other

3 - 8 Connecting Chemistry and the Community

3. COMMUNITY BUILDING (check all that apply)

3.1 Industrial members are active in the section's governance.

3.2 The section communicated with non-ACS members working in industry and local companies about meetings and programs. 3.3 Local companies have financially-sponsored an activity or donated money to the section. 3.4 Industrial members (M), local companies (C), and/or non-members employed in industry (N) participated in these section programs or activities: M C N

Meeting at industrial site/plant tour Local Section Award/Recognition program Membership drive for new members Industrial speaker/Industrially-focused topic National Chemistry Week, Chemists Celebrate Earth Day or other community outreach activity Career development activities

11 Student or younger chemist activities

The section is affiliated with other technical or scientific societies or 3.5 consortia. a. The section affiliated with:

(name of technical organization)

This affiliation was approved by ACS council in what year.

Please indicate groups that your section held 3.6 joint event(s) with:

Local Section Boy/Girl Scouts

Another Professional Community Group Society

BAGIM (Informatics & Modeling) Other 4. MENTORING AND LEADERSHIP (check all that apply)

4.1 The section provided services for pre-college students.

4.2 The section provided speakers for student affiliates chapter meetings. 4.3 The section organized tours of local industries for student affiliates. 4.4 The section offered financial support for student affiliates chapter activities. 4.5 The section offered financial support to students attending regional or national meetings (undergraduate and/or graduate). 4.6 The section appointed a member as student affiliates chapter liaison. 4.7 The section members served as non-faculty professional advisers or contacts for students and young chemists. 4.8 The section provided students with free subscriptions to journals. 4.9 The section invited student affiliates to attend regular section meetings. 4.10 The section sponsored a teacher affiliate group to engage students in ACS. 4.11 The section involved student affiliates in community outreach activities (e.g. National Chemistry Week and/or Chemists Celebrate Earth Day, etc.). 4.12 The section distributed career literature to students or to colleges and universities. 4.13 The section developed and maintained a networking directory. 5. PROFESSIONAL DEVELOPMENT (check all that apply)

5.1 The section published articles on employment services in its newsletter or website.

The section sponsored local employment services (e.g., free ads in section newsletter or website, job counseling, employment clearing 5.2 house).

5.3 A section representative attended a Local Section Career Program offered by the National ACS (if available) during 2007.

5.4 The section referred individuals to the national ACS Department of Career Management and Development.

5.5 The section maintained a job line for career opportunities available within the local section.

12 5.6 The section hosted an ACS short course.

5.7 How many local section career programs or activities were conducted in 2007? 0

a. How many career programs were new in 2007? 9

5.8 The section offered career counseling/literature.

5.9 The section maintains a list (and contact information) of local organizations (networking directory) that employ chemical professionals?

5.10 The section have a Career Coordinator? 6. CONTINUING EDUCATION (check all that apply)

6.1 The section organized a regional meeting.

An ACS Technical Division was involved.

6.2 The Section organized a symposium.

An ACS Technical Division was involved.

6.3 The organized a Meeting-in-Miniature.

An ACS Technical Division was involved.

6.4 The section organized an undergraduate research symposium.

An ACS Technical Division was involved.

6.5 The section organized a meeting that was co-sponsored by an ACS Technical Division.

6.6 The section has topical groups in interdisciplinary areas.

6.7 The section has sponsored meetings with an interdisciplinary focus. 6.8 The section offered activities such as symposia, seminars, or sponsored student activities on environmental issues. 6.9 The section offered specifically tailored symposia, seminars, or sponsored activities for industrial chemical professionals. 7. PUBLIC OUTREACH (check all that apply)

The section provided assistance to K-12 schools by:

7.1 Providing judges for area science fair(s)

7.2 Sponsoring awards at area science fair(s) 7.3 Participate in US National Chemistry Olympiad 7.4 Presenting career programs and/or distributing career literature to students or schools 7.5 Sponsoring or organizing student competitions (e.g., chemistry examinations, ChemBowls, poster competitions) 7.6 Presenting Chemical Demonstrations 7.7 Participating in National US Chemistry Olympiad 7.8 Members making visits to K-8 classrooms. 7.9 Members making visits to 9-12 classrooms

The section encourages participation and leadership in all aspects of the chemical sciences by women (W), underrepresented groups (G), and persons with disabilities (D). (check all that apply) W G D

13 7.10 The section conducted hands-on science activities in elementary and/or middle school classrooms. 7.11 The section sponsored hands-on science activities in underserved communities. 7.12 The section provided summer research opportunities.

7.13 The section developed science career fairs at high schools or colleges that have high female, underrepresented minority or disabled populations.

7.14 The section organized summer science camps. 7.15 The section sponsored contests or awards. 7.16 The section maintained employment services.

7.17 The section leadership (elected or appointed) includes underrepresented groups. 7.18 The section sponsored community outreach activities. 7.19 Section members mentored students or colleagues.

7.20 The section maintained an experts roster and provided it to local media.

7.21 The section created or updated a media list.

7.22 The section prepared a public relations plan and included a copy of this plan in Appendix 4.

7.23 How many times were section activities promoted to the local media (press releases, op-eds, advisories, etc.)? 7.24 The section used an ACS film, videotape, or other ACS visual-aid resource at a public event.

76 7.25 How many talks were given by section members to the public in 2006?

7.26 The section participated in, or conducted the following community activities:

National Chemistry Week

Chemists Celebrate Earth Day

Other:

7.27 The number of community outreach events conducted during National Chemistry Week. 5

7.28 The number of community outreach activities conducted during Chemists Celebrate Earth Day. 2

7.29 The section conducted teacher workshops.

7.30 The section invited teachers to attend section meetings. 7.31 The section provided teachers with free subscriptions to magazines or journals. 7.32 The section involved teachers in section program planning. 7.33 The section participated in Project SEED 7.34 The section provided a forum to address educational issues. 7.35 The section conducted a Science Cafe(s) in 2007.

14

8. ADVOCACY (check all that apply) Local section members interacted with federal government officials. (i.e., members of Congress, agency staff, etc.) 8.1 to encourage funding of research. Local section members interacted with federal government officals (i.e., members of Congress, agency staff, etc.) 8.2 to encourage support for ACS workplace policy issues. 8.3 The section conducted a chemical hygiene, responsible care or environmental health and safety event for the general public. The section offered its services to the local community as a resource on chemical hygiene, responsible care or environmental 8.4 health and safety. 8.5 The section carried out environmental activities for the general public. 8.6 Section has a Government Relations Representative. 8.7 Section hosted a government policymaker (elected, appointed or otherwise) to speak at a local section meeting. Section organized or participated in a special government relations event (state capitol day, science town meeting, legislative 8.8 hearing, public policy forum, etc). Section informed its members on legislative issues and events through newsletter articles, Website, or other communication 8.9 method. 8.10 Section member(s) held an office or key position in state or federal government in 2006. 8.11 The section actively encourages members to join and participated in ACS' Legislative Action Network. 8.12 The section arranged for visits with federal elected officials when they were home on recess.

15

ANNUAL REPORT Northeastern Section, ACS

PART II

ANNUAL NARRATIVE REPORT

http://www.nesacs.org

16 Part II - Annual Narrative Report

Activity 1

Introduction of a special annual symposium catering to the needs of the pharmaceutical, biopharmaceutical and biotech industries in the Boston area.

A seminal event this year was the inaugural “Advances in Chemical Sciences Symposium” conference, held on March 30, 2007: it was a spectacular success. The symposium was a day-long celebration of Chemistry and was held at the Royal Sonesta Hotel in Cambridge, MA. Under the auspices of this conference, eminent scientists from the strategic triad of government and industry and academia delivered plenary lectures. The conference brought together 230 scientists for a scholarly event focusing on medicinal chemistry, organic synthesis and methodology. This year’s plenary lecturers included, Robert Grubbs (Caltech), Steven Ley (Cambridge)), Eric Jacobsen (Harvard), Tomi Sawyer (Pfizer), William Greenlee (Schering Plough) and Mark Murcko (Vertex). The topical focus areas – medicinal chemistry, pharmaceutical and organic synthesis are areas where the chemical enterprise in our area has a well deserved reputation for excellence.

A large number of pharmaceutical and biotechnology industry professionals from the metropolitan area joined us for this event, shared ideas and built networks. The response was extremely enthusiastic. A sell out symposium crowd was treated to some exhilarating science from some of the finest practitioners of the discipline. A vendor show was well attended and appreciated. The symposium was co- sponsored by the US (East Coast) Section of the RSC, and IUPAC. This helped cement our relationships with our colleagues from other societies. Represented on the organizing committee were scientists from many of the Pharma companies in our area. We thus built a nucleus for the future: there is a lot of enthusiasm for having this as an annual event; the 2008 event is being organized: the scheduled date is April 11

2) Planning for ACS collaboration with the Indian Chemical Society and the hosting of ACS Prospectives conferences in India are in full swing

Activity 2

Fostering Greater Professional Interactions with the chemical societies such as the International Union Of Pure and Applied Chemistry and the Royal Society of Chemistry

The annual symposium described above will be routinely co-sponsored (intellectually and financially) by the Royal Society of Chemistry and the International Union of Pure and Applied Chemistry. All our other meetings will be publicized to the membership of these organizations.

Activity 3

Refining the “Career Services” events, co-opting of professional recruiters on our committee and expanding the range of services to outside our section area

The NESACS Professional Career Services Committee is dedicated to providing ACS Members with the best and latest tools to manage careers: we offer career guidance and focus on the components of targeting the job market, personal assessment, identifying market trends, credentials, research and networking. We have a comprehensive (lecture, demo and review) program that provides assistance in writing winning resumes and cover letters, learning various techniques and skills needed for a successful job interview and negotiating an attractive job offer.

Mukund Chorghade, as Chair of this committee attended both National Meetings and actively participated in the work of the ACS Department of Career Services and Professional Development in reviewing resumes and conducting mock interviews. Dr. Daniel Eustace has been a most welcome and effective contributor to these. Special accolades are due to

17 him for helping in redesigning and participating in several innovative ACS presentations and personally leading highly and superbly interactive and novel workshops on interviewing, career development etc. There has been considerable audience participation from employers and interviewees. Both Dan Eustace and Mukund Chorghade have been selected to participate in the ACS National “Train the Trainer’s Program”

Dan Eustace also presented at the afternoon Career Services Employment Seminars that were held preceding the regular meeting of the Northeastern Section. We introduced this as a regular feature in all the monthly meetings (January-June). Typically, a lecture on resume presentations was presented and publications of the ACS National Employment Services were distributed. These publications were also distributed at each of the monthly meetings in the evening. Also, at the monthly meetings assistance with employment was available. This year as an innovative attempt to network employment- seekers with professional recruiters, we co-opted two highly respected industry professionals Megan Driscoll and Jennifer Sass, Pharmalogics recruiting, to our team. These two reviewed resumes and provided guidance on careers. As an added bonus, they assisted some job-seekers get interviews and eventually placements within the pharmaceutical and biotech industries even in locations such as Kansas. Mukund also presented workshops at the Mass College of Pharmacy, University of Wisconsin, Madison, and University of Toledo. Requests have now come in from India and from the Royal Society of Chemistry to do so in London

Activity 4

Science Café’s organized via the speaker’s bureau

As discussed, we embarked on a mission to revitalize the speaker’s bureau. We assembled the best talent in our section and have got a list of refined presentations of broad general interest. We have circulated this list to many schools and community organizations.

A major event that we organized was a “Science-Café” in collaboration with Professor Kathi Browne of Natick High School: we organized this two-hour “in-house field trip for 150 of the best students at Natick high and also for some faculty colleagues.

The program, on October 26 was as follows:

1) Kathi Browne: General introduction 2) Steve Lantos: Ashdown and other scholarship exams, Chemistry Olympiad 3) Mukund Chorghade: The use of chemistry, setting up a Science Club 4) Dan Eustace: Show and Tells regarding the excitement of chemistry and Science 5) John Amedio: Careers, internships etc

Based on the feedback received, the speakers were well appreciated. Students are interested in internships and hearing about additional career opportunities in science. Some have also expressed an interest in joining a science club and in taking part in the various science competitions. Two of the biology teachers present at the assembly asked about the possibility of arranging another assembly where we bring in speakers from the biotech industry. We were able to organize this second event and have Dr. David Pizzi, Sr. Director, Shire Therapeutics and his colleagues visit the school for individual classroom discussions and Q & A.

Activity 5

Education events organized by Ruth Tanner and Steve Lantos

 The 2007 Connections to Chemistry program was held at Burlington High School on Wednesday, October 17th. There were 112 High School Chemistry teachers from 72 schools from Massachusetts, Maine, New Hampshire and Connecticut. Each received a bag with the ACS logo. Among several items in each bag were a copy of the October issue of the Journal of Chemical Education with a username and password for temporary full access to JCE Online

18 (October 17 – November 17, 2007), a copy of the October issue of ChemMatters, and a copy of a recent issue of C&EN that was provided by the ACS. In addition, each participant received a year’s subscription to ChemMatters, and a certificate for three hours of Professional Development. o The participants were welcomed by Mukund Chorghade, the NESACS chair, and by Terri Taylor from the Office of High School Chemistry, ACS Education Division, Washington, DC. o Five workshops were offered in the late afternoon: each teacher participated in two of them. Mukund Chorghade presented a workshop on Careers in Chemistry o Terri Taylor presented a workshop at the program on the high school chemistry initiative by the ACS. o After dinner, the keynote address was given by Dr. Lori Krim Gavrin in Chemical and Screening Sciences from Wyeth Research. o Following the keynote speaker, a raffle was held that included three one-year subscriptions to the Journal of Chemical Education, three one-year memberships in the Division of Chemical Education's/ CTC (Chemistry Teacher Connection), /and various items with the ACS logo.

Activity 6

NCW Event at the Science Museum-Christine Jaworek-Lopes

This was a “celebration of chemistry in the truest” sense of the word

 Seventeen posters were submitted for the NCW poster competition. These posters were judged by the scientists who participated in the Monday program. o The winners from the NESACS were:  K-2: Adam Canfield and Jordyn Cooper (joint entry from the Young Scientists Club, Littleton MA)  grades 9-12: Marina Kem from Malden High School.  October 21, 2007 o More than 50 volunteers from nine organizations assisted in the running of the hands-on activities and demonstrations. o Approximately 300 individuals attended Dr. ’s lecture demonstrations at the Museum. o A “Salutes to Excellence” Award was presented to Dr. Bassam Shakhashiri.  October 22, 2007 o More than 200 students attended the event. Many visitors to the Museum were also able to talk with the scientists in attendance. o Students were asked to complete a word splash at the beginning and at the end of the event to see whether the event positively impacted students’ perception of chemistry. o One student has submitted an essay for the “interview a scientist” option.  For Saturday, October 27, 2007 o More than 40 volunteers from nine organizations assisted in the running of the hands-on activities and demos. o Over 1300 individuals came to the BCM that day and our activities were tried by the majority of those visitors.

Activity 7

Organization of Science Club at the Natick High School

A delightful spin-off of this event was the organization of a Science Club at Natick High School. for helping the students of NHS in promoting the study of science. Kathy Brown of Natick High School was successful in securing a grant to obtain materials to organize a science club, the goal being to encourage students to participate in and compete in local science competitions such as the Science Bowl and the Women in Science Competition. Our local section helped organize this and

19 provided adult support. The school now has a time and location where students can compete in a friendly sort of way and learn additional science concepts as they do.

We were able to help Amrita Karambelkar secure an internship at Tufts Medical School. She was very excited about this, did a project and is now a co-author of a published paper. She was the first high school senior (accepted at Harvard and MIT) to write a special article for the Nucleus.

Activity 8

Ongoing collaboration with GDCh and organization of symposium at the Boston meeting

There were several technical symposia at which NESACS members presided. On Sunday, August 19th, , former NEASCS Chair and current Councilor, Mort Hoffman, delivered the keynote address, “Exploring the High School-College Interface,” at the Division of Chemical Education’s High School Program. That same afternoon, the Division of Chemical Education, collaborating with many other ACS Divisions and Committees, sponsored the symposium, “Connections to Germany: Research and Education Opportunities”, at which participants in NESACS’s signature German Exchange Program were be featured. A grand reception followed, at which many of NESACS’s activities were highlighted.

On Tuesday, August 21st, the Younger Chemists Committee and the Division of Business Management sponsored the symposium, Changing Landscapes of the BioPharma Industry, which highlighted the many novel accomplishments of the biopharmaceutical industry. Symposium organizer and NESACS member, Michael Hurrey, of Vertex Pharmaceuticals gathered an impressive group of presenters: Patrick Connelly of Vertex Pharmaceuticals talked about translational product development and the application of advances in and materials science to enhance drug discovery & development. NESACS Chair, Mukund Chorghade, CEO of Chorghade Enterprises, discussed the multi-disciplinary nature of biotechnology and its effect on the job market. Susan Wollowitz, Vice President of Medivation, Inc, addressed the changing landscape of dosage forms, changing industry needs and science challenges.

Later that afternoon, the Division of Professional Relations held a symposium in honor of NESACS’s Arlene and Ted Light, the 2007 recipients of the ACS Henry Hill Award conferred by the Division. Organized and moderated by NESACS Chair, Mukund Chorghade, the symposium included Elaine Diggs and John Sophos of ACS, who had worked with the Lights from the ACS Department of Career Services; Dan Eustace of Multi-Layer Coating Technologies and organizer of many ACS career workshops; and James Burke, former Chair of the ACS Board of Directors. The symposium proved to be a fitting tribute to the Lights’ many contributions to ACS and to the career development of its members. The award was presented at a reception following the symposium, to which all are invited.

Wednesday afternoon, August 22nd, the Division of Professional Relations, with the assistance of the Women Chemists Committee, hosted another symposium, Sisters in Science. Organizer Pam Mabrouk, Past Chair of NESACS, assembled a distinguished array of speakers who illuminated accomplishments of African American women chemists. Jeannette Brown described some of her findings during the preparation of her history of African American women chemists. Esther Hopkins, retired from a variety of careers including those of chemist and patent attorney, and who is currently an elected legislator, described “a certain restlessness.” NESACS Board member and ACS Councilor, Dorothy Phillips of Waters Corporation, highlighted the roads that unite R&D and business careers. Gilda Barabino, Professor at Georgia Institute of Technology, spoke on African American women and research in the Academy. And Sharon Neal, Professor at the University of Delaware gave her view of the life of an African American woman in academia.

These symposia illustrate the range of interest and engagement that our NESACS members displayed. Michaeline Chen reminded the committee of the erstwhile custom of opening the Council meeting with a trumpet fanfare played by then-Councilor John Verkade. Suggesting that we try to revive this tradition, Michaeline identified a music student, Patrick Doyle, who was available to perform, and at a very reasonable rate. The ACS leadership approved this activity and agreed to keep it secret. At the beginning of the Council meeting, Mr. Doyle performed a fanfare of his own composition, which was

20 greeted by enthusiastic applause and cheering. Appropriately, Michaeline was publicly thanked in the Council meeting.

A short time after the end of the ACS meeting, ACS President Katie Hunt sent the following email:

Bob,

I just have to tell you that Patrick and his trumpet fanfare started Council off on a magnificent note!

This is a Council meeting that I will not soon forget! Thank you again for a your part and your section's part in "making this so"!

p.s. I do owe you an official THANK YOU but I wanted to get at least an 'unofficial' thank you ....ON THE RECORD!

very best regards, Katie

Many thanks to Michaeline for conceiving of the idea and carrying it out.

Activity 9

Formation of a special Government Affairs committee

Doris Lewis spearheaded the formation of a special Government Affairs Committee to more effectively liaise with our Congressional leaders at the local and federal government level. The section efforts will be tremendously enhanced by having a person with Doris’s stature

Activity 10

Networking and fund-raising events such as golf tournaments

Networking and fund-raising events such as golf tournaments: These provided a great and fertile forum for NESACS members to relax and meet fellow chemists in a very informal but professional setting. Amy Tapper hosted a golf tournament at which several leading executives from the innovator companies and contract research organizations intermingled for “friendly rivalry”, camaraderie and sportsmanship. There were other networking get-to-gethers all designed to afford our members to expand their intellectual and professional horizons. Needless to say, these proved to be a great boon for our fund-raising committee

Summary

It has been a singular honor and privilege to serve as Chair for the Northeastern Section. The breadth, depth and sophistication of the talent and creativity of the individuals in the section are truly outstanding. We have eminent researchers and professionals from all sub-disciplines of chemistry. We enjoy a cherished and hallowed tradition of excellence. The warmth and gracious hospitality with which we welcome participation by our members, collaborators and distinguished guests has been the hallmark of our tradition and the well-spring of our progress

The ambitious goals we set ourselves were (1) Foster greater interactions between the ACS and the other professional bodies catering to the cause of chemistry - The American Institute of Chemists and the International Union of Pure and Applied Chemistry come readily to mind. This has been met in good measure and has exceeded all our expectations This

21 will be the forerunner of an annual Life Sciences Symposium and could provide a useful forum for productive exchange of ideas. (2) Encourage a vitalized speakers bureau to provide guest lectures to schools, universities and civic and community groups. The topics can encompass issues of topical interest, e.g., chemical safety, environmental and the contributions made by chemists/chemistry to the benefit of society at large. This goal has been met, beyond expectations by the assembling of a very talented team and organizing two major events at Natick High School. We will expand this to other area schools (3) Expand the activities of the Professional Training/Education and Career Services committees. Regular workshops will be used to educate students at local colleges/universities and mid-career professionals about the diverse opportunities in chemistry, current trends in globalization, resume writing, interviewing skills/techniques and related topics. Such workshops will also benefit mid career and chemists undergoing a career transition. We exceeded all these goals. Dan Eustace also presented at the afternoon Career Services Employment Seminars that were held preceding the regular meeting of the Northeastern Section. We introduced this as a regular feature in all the monthly meetings (January-June). Typically, a lecture on resume presentations was presented and publications of the ACS National Employment Services were distributed. These publications were also distributed at each of the monthly meetings in the evening. Also, at the monthly meetings assistance with employment was available. This year as an innovative attempt to network employment-seekers with professional recruiters, we co-opted two highly respected industry professionals Megan Driscoll and Jennifer Sass, Pharmalogics recruiting, to our team. These two reviewed resumes and provided guidance on careers. As an added bonus, they assisted some job-seekers get interviews and eventually placements within the pharmaceutical and biotech industries even in locations such as Kansas. Mukund also presented workshops at the Mass College of Pharmacy, University of Wisconsin, Madison, and University of Toledo. Requests have now come in from India and from the Royal Society of Chemistry to do so in London

(4) Build a much-needed bridge between the medicinal and process chemistry groups and facilitate via symposia and discussion groups new perspectives on the progress of a drug from conception to commercialization. This has been met by organization of the symposia described above (5) Increase opportunities for networking among chemists. Greater emphasis will be placed on attracting chemists in the biotechnology / biopharmaceutical industries and participation of their employers via corporate sponsorships. This goal has been met and all our expectations have been exceeded. The symposia drew a lot of corporate sponsorships from companies and vendors alike. Successful golf tournaments also provided a very exciting forum for networking (6) Stimulate additional participation of the section in the international activities of the ACS. Our members are involved in a wide array of activities here-the collaboration with the German Chemical Society has been outstanding! Plans are well under way for extensive collaboration with the Indian and the Chinese Chemical Societies. One of ACS’s most successful mechanisms for delivering highly focused technical content in the has been through the ProSpectives series of conferences. The prestigious “ProSpectives” conference will be organized at various locations in India and China. We were pleased to exceed all these goals . So, my eternal debt of gratitude goes out to our members, who joined us in what was an outstanding year of progress and additional programs. Volunteers like these are a tremendous source of ideas that constitute the lifeblood of an organization. They have rendered yeomen assistance in providing creative inputs into the programs and increasing the public’s awareness and enjoyment of Chemistry

Local Section and Chair Goals

2007 Goal Attainment. The Local Section Activities Committee strongly encourages local section planning. As a result, the 2007 local section annual report should follow-up on the attainment of goals. Please list the goals you set at the beginning of your term for your section and yourself, and report on the attainment of the goals.

Local Section Goals and Assessment (1) Build a much-needed bridge between the medicinal and process chemistry groups and facilitate via symposia and discussion groups new perspectives on the progress of a drug from conception to commercialization.

Goal 1 Assessment:: This has been met by organization of the symposia described above

(2) Increase opportunities for networking among chemists. Greater emphasis will be placed on attracting chemists in the biotechnology / biopharmaceutical industries and participation of their employers via corporate sponsorships

22

Goal 2 Assessment: This goal has been met and all our expectations have been exceeded. The symposia drew a lot of corporate sponsorships from companies and vendors alike. Successful golf tournaments also provided a very exciting forum for networking

(3) Stimulate additional participation of the section in the international activities of the ACS.

Goal 3 Assessment: Our members are involved in a wide array of activities here-the collaboration with the German Chemical Society has been outstanding! Plans are well under way for extensive collaboration with the Indian and the Chinese Chemical Societies. One of ACS’s most successful mechanisms for delivering highly focused technical content in the United States has been through the ProSpectives series of conferences. The prestigious “ProSpectives” conference will be organized at various locations in India and China. We were pleased to exceed all these goals

2007 Chair's Goals and Assessment (1) Foster greater interactions between the ACS and the other professional bodies catering to the cause of chemistry

Goal 1 Assessment:: The American Institute of Chemists and the International Union of Pure and Applied Chemistry come readily to mind. This has been met in good measure and has exceeded all our expectations This will be the forerunner of an annual Life Sciences Symposium and could provide a useful forum for productive exchange of ideas.

(2) Encourage a vitalized speakers bureau to provide guest lectures to schools, universities and civic and community groups. The topics can encompass issues of topical interest, e.g., chemical safety, environmental and the contributions made by chemists/chemistry to the benefit of society at large.

Goal 2 Assessment:: The topics can encompass issues of topical interest, e.g., chemical safety, environmental and the contributions made by chemists/chemistry to the benefit of society at large. This goal has been met, beyond expectations by the assembling of a very talented team and organizing two major events at Natick High School. We will expand this to other area schools

(3) Expand the activities of the Professional Training/Education and Career Services committees. Regular workshops will be used to educate students at local colleges/universities and mid-career professionals about the diverse opportunities in chemistry, current trends in globalization, resume writing, interviewing skills/techniques and related topics. Such workshops will also benefit mid career and chemists undergoing a career transition.

Goal 3 Assessment:: We exceeded all these goals. Dan Eustace also presented at the afternoon Career Services Employment Seminars that were held preceding the regular meeting of the Northeastern Section. We introduced this as a regular feature in all the monthly meetings (January-June). Typically, a lecture on resume presentations was presented and publications of the ACS National Employment Services were distributed. These publications were also distributed at each of the monthly meetings in the evening. Also, at the monthly meetings assistance with employment was available. This year as an innovative attempt to network employment-seekers with professional recruiters, we co-opted two highly respected industry professionals Megan Driscoll and Jennifer Sass, Pharmalogics recruiting, to our team. These two reviewed resumes and provided guidance on careers. As an added bonus, they assisted some job-seekers get interviews and eventually placements within the pharmaceutical and biotech industries even in locations such as Kansas. Mukund also presented workshops at the Mass College of Pharmacy, University of Wisconsin, Madison, and University of Toledo. Requests have now come in from India and from the Royal Society of Chemistry to do so in London

2008 Goals. (This section should be completed by the 2008 local section chair.) Please list below at least three goals that you and your local section plan to accomplish during your term as local section chair.

2008 Local Section Goals (Include at least three goals):

23 NESACS has a very stable, dedicated and talented Board of Directors. Many of these participants are older chemists and a large number are retired or nearing retirement age. There is a significant body of student chemists, academic chemists, and industrial chemists in our section but very little participation by these groups in the monthly meetings or in the activities of section committees. This needs to change. Therefore, the section leadership must:

1. Create and identify attractive opportunities for active participation in section activities by current/new members;

2. Effectively and efficiently communicate these;

3. Add new active participants to the section leadership core.

It should be noted that the section has made some progress in recent years towards these fundamental goals (reenergizing the YCC, creation of an annual golf tournament, etc.). We plan to build on these initial efforts as we continue working towards our goals.

2008 Chair's Goals:

Goal 1: Work with the Program Chair/Chair-Elect to identify and implement different programming types for the section’s monthly meetings, with the goal being to increase average attendance at and interest in the monthly meetings.

Goal 2: Continue to explore possible collaborations with special interest groups such as Silver Circle and WCC with an eye to incorporating branches of these groups within the section.

Goal 3: Work with the Board of Publications to improve communication within the section (monthly newsletter, website, blog, perhaps targeted emails), in order to inform the membership in as many ways as possible about new section activities

D. Suggestions/Concerns List any suggestions you have for the Local Section Activities Committee (LSAC). How can LSAC specifically help your section?

24

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 1

SUPPORTING DOCUMENTS FOR ACTIVITIES

http://www.nesacs.org

25 APPENDIX 1 - SUPPORTING DOCUMENTS FOR ACTIVITIES

ACTIVITY 1

Introduction of a special annual symposium catering to the needs of the pharmaceutical/biopharmaceutical and biotech industries in the Boston area: Advances in Chemical Sciences Symposium

Inaugural Symposium Advances In Chemical Sciences Symposium sponsored by NESACS, IUPAC and RSC-US

Royal Sonesta Hotel Cambridge, MA

March 30, 2007 9:00 a.m.

The conference will bring together 200+ scientists for a scholarly event focusing on  medicinal chemistry  organic synthesis  methodology.

Eminent scientists from the strategic triad of government and industry and academia will deliver plenary lectures. Lecturers include  Robert Grubbs California Institute of Technology  William Greenlee Schering Plough  Eric Jacobsen  Steven Ley Cambridge University  Tomi Sawyer Pfizer Research Technology Center Additional speakers will be announced soon.

The proposed topical focus areas – medicinal chemistry, pharmaceutical and organic synthesis are areas where the chemical enterprise in our area has a well-deserved reputation for excellence. We invite you to join us for this event, share ideas and build networks.

Symposium registration fee: $ 35.00 Please send your contact information along with your check for $35 made payable to NESACS to Dr. James Piper Treasurer, NESACS 19 Mill Road Harvard, MA 01451

26 Advances In Chemical Sciences Symposium sponsored by NESACS, IUPAC and RSC-US 8:15-9:00 Registration 9:00-9:10 Welcome, Mukund Chorghade, Chair NESACS & Les McQuire, RSC-US

9:10-10:10 Mark Murcko, Vertex “” Introduced by Gabriel Martinez-Botella

10:10-11:10 Eric Jacobsen, Harvard University “” Introduced by Scott Cowen

11:10-12:10 Tomi Sawyer, Pfizer “Exploring Chemical Space in Protein Kinase Inhibitor Drug Discovery” Introduced by Michael Pollastri

12:10-1:30 Lunch Break

1:30-2:30 Steve Ley, Cambridge University, “The Changing Face of Organic Synthesis” Introduced by Ralph Scannell

2:30-3:30 William Greenlee, Schering Plough, “Discovery of Orally-Bioavailable Non-Peptide Thrombin Receptor Antagonists for the Prevention of Thrombosis” Introduced by David Calderwood

3:30-4:00 Break

4:00-5:00 Robert Grubbs, California Institute of Technology “” Introduced by John Amedio

Closing Comments - John McKew

5:00-6:30 Vendor Exhibition and Networking Reception

27

ACTIVITY 2

Fostering Greater Professional Interactions with the chemical societies such as the International Union of Pure and Applied Chemistry and the Royal Society of Chemistry

28 ACTIVITY 3

Refining the “Career Services” events, co-opting of professional recruiters on our committee and expanding the range of services to outside our Section area

NESACS Career Services at Monthly Meetings The NESACS Career Services Committee In general our members have provided is dedicated to providing ACS positive feedback. Reproduced Members with the best tools to manage below are comments from one member careers. We offer career guidance and who benefited from our programs: focus on the components needed for “My career counseling session with Dr. targeting the job market: personal Chorghade began with some basic assessment, identifying market trends, questions designed to engage me and credentials, research and networking. focus me on clearly stating my objectives. We have a comprehensive (lecture, The process of reviewing my CV demo and review) program that provides began with an examination of its overall assistance in writing winning structure and an assessment of the resumes and cover letters as well as impression of prospective screeners. various techniques and skills needed This overview was followed by a for a successful interview. detailed review focused on content, In collaboration with the Speaker’s wording and vocabulary. I have read Bureau, we will organize a program of several books on resume writing and resume reviews and short lectures attended many workshops. The assistance focusing on current topics at Section that I received through ACS Meetings. Two distinguished recruiters career services has been the most in our area, Megan Driscoll and Jennifer knowledgeable and helpful that I have Sass of PharmaLogics Recruiting, experienced. While the improvements will join me in offering valuable perspectives to my CV are significant, the feedback and 1:1 career counseling to I received on my qualifications and members. These sessions will typically search strategies was profound. The be held between 2:30 pm and 4:30 pm. best part of the process is the quality of Members will be able to benefit from assistance and sincere caring of the such networking: this will be a regular counselor.” feature of Section Meetings in 2007.

Career Services Are you interested in changing jobs? Do you wonder whether your interviewing abilities could be enhanced? Could your resume use some work? If yes, please join us at the January meeting, where you can receive advice from industry professionals. Topics and services which we will cover: how to put together an eyecatching resume, best interviewing strategies, and how to find the most appropriate opportunities u

29 Sample meeting notice - Career Services offered at every meeting

30 ACTIVITY 4

Science Cafés organized via the Speakers’ Bureau

From: Elaine Diggs [mailto:[email protected]] Sent: Wednesday, April 25, 2007 11:10 AM Subject: 2007 Science Mini-grants

Dear Local Section Leader: <>

We are pleased that you applied for and received a mini-grant from the Local Section Activities Committee (LSAC) last year to conduct a Science Café in your local section. If your event has already taken place, please take a few minutes to complete the attached report form to let us know how things went. If you have not conducted your

31 science café yet, please tell us when you are planning the event, where it will take place, the topic of the café and/or the speaker who will be participating.

Thank you for your efforts to coordinate the Science Café in your local section to raise the level of scientific literacy in your community. Your local section will be receiving information soon about funding available to continue this program for next year, so be sure to check with your Chair.

Elaine M. Diggs Sr. Membership Associate American Chemical Society Division of Membership and Scientific Advancement Dept. of Local Sections & Community Activities 1155 Sixteenth St., N.W. Washington, D. C. 20036 (202) 872-6149 (phone) (800) 227-5558, x6149 (toll-free) (202) 872-4353 (fax) [email protected]

From: DANIEL EUSTACE [mailto:[email protected]] Sent: Wednesday, October 10, 2007 9:37 AM To: Karanjikar, Mukund R; Chorghade Subject: Fw: Best Practices Teleconference

Mukund,

Elaine sent me a link to podcasts from all around the country.

I participated in one in April and wanted ot have it linked to my blog....

This is something that could be one of the end-products of the Natick High School program. It could also be placed on the web page as a podcast.

Dan

----- Original Message -----

From: Elaine Diggs

To: DANIEL EUSTACE

Sent: Wednesday, October 10, 2007 8:59 AM

Subject: RE: Best Practices Teleconference

Dan,

32 Go to https://portal.acs.org/portal/acs/corg/memberapp?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1220&u se_sec=false. Not only is the June teleconference on NCW available as streaming or downloadable content, but there is a later teleconference on Science Cafes from mid-September that is also available from this link.

Elaine M. Diggs Membership Specialist American Chemical Society Division of Membership and Scientific Advancement Dept. of Local Sections & Community Activities 1155 Sixteenth St., N. W. Washington, D. C. 20036 (202) 872-6149 (phone) (800) 227-5558, x6149 (toll-free) (202) 872-4353 (fax) [email protected]

33 ACTIVITY 5

Education events organized by Ruth Tanner and Steve Lantos

Please refer to total report of the Education Committee on Pages 84-110 in Appendix 5 for a more complete description of the responsibilities and activities of the Education Committee listed below.

The Education Committee coordinates activities involving students at the secondary school, undergraduate, and graduate levels as well as conducting programs for high school teachers; i.e.,

High School Students: Ashdown Examination - qualifying examination for the Olympiad Exam Olympiad Exam administered locally Project SEED

College Students: Norris-Richards Undergraduate Research Summer Scholarships Grants-in-Aid to attend the ACS National Meeting Phyllis A. Brauner Prize Book Award Student Affiliates at Local Colleges and Universities ACS Scholars at Local Colleges and Universities

High School Teachers Connections to Chemistry Registration Grants to attend ACS National Meeting in Boston Richards Award for Excellence in Teaching Secondary School Chemistry Aula Laudis Honor Society of High School Chemistry Teachers Newell Grants to attend NEACT Summer Conference High School Day held at the ACS National Meeting in Boston

Programs conducted in conjunction with others: Northeast Student Chemistry Research Conference (with YCC) German Exchange Program (with YCC and JCF/GDCh) Undergraduate Environmental Research Symposium (with Bridgewater State College)

The Annual Education Awards Night Program is coordinated by the Education Committee

34

(l-r) James Fabiano (Newmarket (NH) Junior-Senior High School), recipient of the Theodore William Richards Award for Excellence in Teaching of Secondary School Chemistry; Kristin Kiefaber (Newmarket (NH) Jtounior-Senior High School); Scott Weber (Newmarket (NH) Junior-Senior High School); Steve Lantos (Brookline (MA) High School), NESACS High School Education Committee Chair. (Photo by Morton Z. Hoffman)

35

36

ACTIVITY 6

NCW Event at the Science Museum - Christine Jaworek-Lopes

Excerpt from the NCW Committee Report

On Sunday, October 21, 2007, the Northeastern Section of the American Chemical Society sponsored a National Chemistry Week 2007 Kick-Off Event at Museum of Science-Boston (MoS). More than 50 volunteers (from ACS, Boston Latin High School, the Brauner Committee, Emmanuel College, Malden High School, Merck Research Laboratories – Boston, Stonehill College, Suffolk University, Tufts University) ensured that the more than 1000 visitors to the daylong event enjoyed a number of hands-on activities.

Hands-on activities included: isolating iron from Total cereal, making play putty, studying the chemistry of different types of nails, making UV detector bracelets, making marker butterflies, assessing sugar content in cereals and beverages, and learning how mood lipsticks work.

Among the highlights of the day were the two lecture demonstrations, as part of the Phyllis A. Brauner Memorial lectures, presented by Dr. Bassam Shakhashiri, Professor of Chemistry at the University of Wisconsin-Madison. These captivating lectures were enjoyed by children and adults alike. Approximately 300 individuals attended these lectures which were free with admission to the MoS. In addition, Dr. Shakhashiri was presented with a Salute to Excellence Award for his continued involvement with the NESACS NCW events.

On October 22, 2007, a diverse audience of 225 area high school students participated in a daylong program at the Museum of Science-Boston highlighting the variety of careers impacted by chemistry. This program was funded by receipt of a Local Section Innovative Grant, local section funds, and a donation from Merck Research Laboratory – Boston. Each student received free admission to the museum as well as a bag containing a notebook, a pen, the current issue of Chem Matters, the current issue of Celebrating Chemistry, a periodic table of elephants, a nanomole, and a bag of UV-sensitive beads. Each teacher received in addition to the student bags a mug and the ACS pamphlet entitled,” I Know You are a Chemist But What Do You Do?”

The day commenced with the students participating in an interactive a lecture-demonstration given by Dr. Bassam Shakhashiri. The students then had the opportunity to meet and talk at informal conversation stations with the scientists from a variety of organizations. Each scientist brought a hands-on activity or demonstration to encourage conversation. The scientists that participated in this event were:

 Marta Biarnes – a former cosmetic chemist from L’Oreal USA, now a member of the MoS staff  Jennifer Chute – Criminalist, Boston Police Department Crime Lab  Raksmey Derival – Program Manager, Beyond Benign  Pamela Hatchfield –Head of Objects Conservation, Museum of Fine Arts, Boston  Peter Jepson – Materials Scientist, H.C. Starck  Christian Krahforst – Staff Scientist, Massachusetts Bays National Estuary Program  Mimi Leveque – Art Conservator, Peabody Essex Museum  Jacqueline Massua – Forensic Laboratory Technician, Boston Police Department Crime Lab  James Waters – Technical Support, Waters Corporation  Bassam Shakhashiri – Professor of Chemistry, University of Wisconsin-Madison

37 The students also had the opportunity to participate in two hands-on activities related to nutrition and tour the MoS. Finally, students had the option of interviewing a scientist and submitting the interview to the NCW committee. Four students participated in this.

Student interviewing Dr. Bassam Shakhashiri

Overhead view of the Monday program in action.

38 ACTIVITY 7

Organization of Science Club at Natick High School

From: Kathi Browne [mailto:[email protected]] Sent: Friday, June 08, 2007 3:13 PM To: Chorghade Subject: Science Club

Mr. Chorghade,

Earlier this year you talked about the possibility of helping the students of NHS in promoting the study of science. I have written a grant to obtain materials to organize a science club, the goal being to encourage students to participate in and compete in local science competitions such as the Science Bowl and the Women in Science Competition. I have not yet made this known to the students but am wondering if you might be able to help us organize this and provide adult support. I am hoping to offer a time and location where students can compete in a friendly sort of way but learn additional science concepts as they do. If you think you would be interested in helping with this I would appreciate hearing from you. There is no rush as we do have the summer ahead of us. Please let me know if this is of interest to you.

Thanks, Kathi Browne Natick High School

From: Kathi Browne [mailto:[email protected]] Sent: Wednesday, October 31, 2007 8:05 AM To: Mukund Chorghade Subject: Re: Copy of presentations. Will send Amedio's separately

Mukund,

I want to thank you again for arranging the assembly on Friday. Based on the feedback I've received, the speakers were well received. Students are interested in internships and hearing about additional career opportunities in science. Some have also expressed an interest in joining a science club and in taking part in the various science competitions.

Two of the biology teachers present at the assembly asked about the possibility of arranging another assembly where we bring in speakers from the biotech industry. I'd like to begin arranging a similar program where the focus is on biology and biotech related fields. If you know of anyone who might be willing to speak to the students, either in a large group setting or in a smaller classroom setting, please let me know.

I will mail the receipts for the food and drinks to you. I've saved the remaining water for an upcoming science club meeting.

Thanks again for all your help.

Kathi

From: DANIEL EUSTACE [mailto:[email protected]] Sent: Wednesday, October 10, 2007 9:37 AM

39 To: Karanjikar, Mukund R; Chorghade Subject: Fw: Best Practices Teleconference

Mukund,

Elaine sent me a link to podcasts from all around the country.

I participated in one in April and wanted ot have it linked to my blog....

This is something that could be one of the end-products of the Natick High School program. It could also be placed on the web page as a podcast.

Dan

----- Original Message -----

From: Elaine Diggs

To: DANIEL EUSTACE

Sent: Wednesday, October 10, 2007 8:59 AM

Subject: RE: Best Practices Teleconference

Dan,

Go to https://portal.acs.org/portal/acs/corg/memberapp?_nfpb=true&_pageLabel=PP_ARTICLEMAIN&node_id=1220&u se_sec=false. Not only is the June teleconference on NCW available as streaming or downloadable content, but there is a later teleconference on Science Cafes from mid-September that is also available from this link.

Elaine M. Diggs Membership Specialist American Chemical Society Division of Membership and Scientific Advancement Dept. of Local Sections & Community Activities 1155 Sixteenth St., N. W. Washington, D. C. 20036 (202) 872-6149 (phone) (800) 227-5558, x6149 (toll-free) (202) 872-4353 (fax) [email protected]

40

ACTIVITY 8

Ongoing collaboration with GDCh and organization of symposium at the Boston meeting

The Northeastern Section of the ACS part of the rapidly developing ACSGDCh (NESACS), its Younger Chemists interaction. Begitt suggested to Committee (YCC), and its Education Strem that his company, which is Committee will host a visit to Boston located in Newburyport, MA, and has in August 2007 by representatives of an international operation, might wish the Young Chemists Forum to exhibit its products at the (Jungchemikerforum, Chemiedozententagung, the annual JCF) of the German March meeting of the GDCh at which Chemical Society (Gesellschaft postdoctoral fellows, who are searching Deutscher Chemiker, GDCh) as the for an academic job in Germany, seventh annual event of the exchange present their work to interested German program between NESACS and professors. At the meeting in GDCh. The German delegation of 2000, Strem saw an exhibit by the JCF. fourteen graduates, accompanied by He recognized immediately that this Kurt Begitt, Deputy Executive Director group and its members were very similar and Director of Education and Professional in purpose and organization, membership Affairs of the GDCh, will age, and stage of professional spend a week in Boston at the time of career to that of the NESACS YCC. the ACS National Meeting. In the course of the Chemiedozententagung, The visit will give the German Strem and Begitt discussed graduate students the opportunity to the idea of a cooperative program experience that event, with its associated between JCF and the NESACS YCC, exposition and social events; in which each group would alternate interact and network with the other hosting the other in Boston or in Germany graduate students in attendance; and for one week each year. The present the results of their research in a plan that evolved would have the visits scientific forum. The presence of the built around a symposium at which the German delegation at the meeting will young chemists would make oral or spotlight the ACS international efforts, poster presentations that describe their as demonstrated by the close ties that research work. There would also be exist between the ACS and the GDCh. visits to academic and industrial Origins of the Exchange research facilities in the geographic The beginning of the connection area, in addition to social and cultural between NESACS and GDCh occurred events that would develop personal when Michael Strem (Strem Chemicals, interactions among the participants. Inc.), a member of the ACS Board Upon his return to Boston, Strem of Directors from District I (1997- presented the idea to the NESACS 2000) and a member of the NESACS Education and Younger Chemists Board of Directors, met Kurt Begitt as Committees and the Board of Directors

41 and reported that GDCh would be prepared NESACS, as the host for this visit, to send a group of German graduate is providing lodging for its guests, and students to Boston in 2001. A has organized excursions, laboratory committee to organize the Exchange visits, and other events of a scientific was formed, comprising Michael and cultural nature. The costs for Strem as Chair; Ruth Tanner (UMass lodging and registration at the meeting Lowell), NESACS Education Committee have been partially defrayed by the Chair; Morton Hoffman (Boston DAC grant and a grant to NESACS University), NESACS Chair-Elect; from the ACS Local Section Activities Amy Tapper (Boston University), YCC Committee. Chair; Tim Frigo (Advanced Magnetics, Following is a list of the German Inc.), NESACS Chair; and Doris graduate students, their institutions, the Lewis (Suffolk University), NESACS titles of their research posters, and the Immediate Past-chair. Because divisions and times of their presentations. NESACS would serve as the host of Check the ACS website the 2001 Exchange, its Board appropriated or the meeting program sufficient funds to provide lodging, in C&EN for the locations of local transportation and meals, and these sessions. excursions for the JCF visitors. German Delegation Dominik Margraf [Information relating to the Exchanges Johann Wolfgang Goethe-Universität, from 2001 through 2006 may be found Frankfurt am Main in the Nucleus - Summer 2007 issue] “Pulsed electron-electron double resonance: Beyond measuring distances” 2007 Exchange (August 18-25) PHYS, Wednesday, 7-9 p.m. The German Delegation will Cathrin Corten attend the ACS meeting, display Technische Universität Dresden research posters in the relevant technical “Multi-sensitive hydrogel thin films: divisions and at Sci-Mix (Monday, From synthesis to application” 8-10 p.m.), and participate in a reception PMSE/POLY, Tuesday, 7-9 p.m. in their honor (Sunday 5:30-7 Eva-Maria Jahn p.m.). Four of the students (and Ludwig-Maximilians Universität Begitt) will present oral contributions München in a symposium in the Division of “Synthetic approach to natural tRNA Chemical Education (CHED), Connections modifications” to Germany: Research and Education ORGN, Sunday, 8-10 p.m. Opportunities, on Sunday Helke Döring afternoon, 1:30-5 p.m., in Plaza A of Technische Universität Chemnitz the Seaport Hotel. “Kinetic measurements using catalyst In addition, thanks to an Innovative I&EC, Tuesday, 8-10 p.m. Projects Grant from the ACS Divisional Naho Fujimoto Activities Committee to CHED, Forschungszentrum Borstel Dr. Marianne Sgoff, a high school “Glycosylceramides: Synthesis and teacher of chemistry in Germany, will biophysical properties” come to Boston for the ACS meeting. ORGN, Sunday, 8-10 p.m. She will speak in the CHED High Dominik Albrecht School Program (The High School- Technische Universität München College Interface) on Sunday morning “Enantioselective intramolecular at 9:10 a.m. on “Challenges of Teaching [2+2]-photocycloaddition reactions of High School Chemistry in Germany” tetramic acid esters and their structural in Plaza B of the Seaport Hotel. homologues mediated by a chiral lactam

42 host” in Chemnitz, March 22-24, where she ORGN, Tuesday, 8-10 p.m. presented a poster on the activities of Tom Grossmann the NESACS-YCC. Humboldt Universität, Berlin Symposium (Sunday, 1:30-5 p.m.), “DNA-catalyzed organic transfer reaction Plaza A, Seaport Hotel for sequence-specific DNA-detection” The symposium, with CHED as the ORGN, Sunday, 8-10 p.m. sponsoring technical division, has been Philipp Wacker organized by Hoffman and is cosponsored Universität Potsdam by the German Chemical Society, “Conformational analysis and ring current ACS International Activities effects of porphyrins studied by Committee, CHED International Activities molecular modeling” Committee, ACS Northeastern ORGN, Wednesday, 8-10 p.m. Section, Graduate Student Symposium Jens Breffke Planning Committee, Society Committee Humboldt Universität, Berlin on Education, Women’s Chemist “No dual fluorescence in trans-4- Committee, Younger Chemists Committee, dimethylamino-4’-cyanostilbene and the ACS President. The (DSC)” schedule is as follows: PHYS, Wednesday, 7-9 p.m. 1:30 – Welcoming remarks Jörg-Joachim Nitz 1:35 – Eva-Maria Jahn, Biological Max Planck Institut für Kohlenforschung, chemistry research at Ludwig-Maximilians Mülheim an der Ruhr University “Spatially controlled functionalization 1:55 – Tom Grossmann, DNA as catalyst of ordered mesoporous carbons” in organic synthesis: An COLL, Monday, 6-8 p.m. approach for sequence-specific Igor Schapiro DNA detection Universität Duisburg-Essen 2:15 – Cathrin Corten, Characterization “Ab initio molecular dynamics of of smart materials synthesized visual pigment chromophore models” via controlled radical polymerization COMP, Tuesday, 6-8 p.m. 2:35 – Intermission Hanns Martin Kaiser 2:45 – Christian Schäfer (DAAD), Universität Rostock Funding academic exchange and “New synthetic protocols for the promoting research in Germany preparation of unsymmetrical bisindoles” 3:05 – Georg Bechtold (German ORGN, Wednesday, 8-10 p.m. Research Foundation), Basic Peter Wich research in Germany Universität Würzburg 3:25 – Claudia Jopp (Boston Consulting “Stereoselective binding of peptides by Group), The Boston Consulting artificial receptors in water: New Group Germany insights into the molecular recognition 3:45 – Intermission of biologically relevant substrates” 3:55 – Kurt Begitt and Jens Breffke, ORGN, Sunday, 8-10 p.m. The German Chemical Society and Franziska Luschtinetz chemical education and research in Universität Potsdam Germany “New perspectives on fluorescence 4:20 – Laila Dafik, Younger Chemists probes for protein single molecule Committee of the Northeastern Section spectroscopy” 4:40 – Morton Hoffman, Study abroad PHYS, Wednesday, 7-9 p.m. opportunities in Germany for American Laila Dafik (YCC Chair, Tufts U) met science and engineering undergraduates many of the members of the German Reception (Sunday, 5:30-7 p.m.), delegation at the Frühjahrssymposium Lighthouse Ballroom 2, Seaport

43 Hotel Plans are being developed for the At the reception, the research posters next Exchange in 2008, when a delegation of the German students and posters from NESACS will travel to Germany from JCF, YCC, and other sponsors for the Frühjahrssymposium in will be on display, providing an opportunity Rostock, March 27-29. We hope that for attendees to speak to the presenters the Exchange will continue with in the informal setting. In another visit by undergraduates and addition, tables for the display of materials graduate students from NESACS to by the sponsors of the reception Germany in 2009. We look forward to will also be available. Some short welcoming the opportunity to welcome JCF to remarks will be made, and it is Boston in August 2010 on the occasion anticipated that some Salutes to Excellence of the next ACS National Meeting in awards will be presented. the Hub. The sponsors of the reception are This article was compiled by Morton NESACS, CHED, Graduate Student Hoffman, Ruth Tanner, and Michael Symposium Planning Committee, Strem. Information obtained from articles GDCh, DAAD, the Boston Consulting in The NUCLEUS by Suzann Group, and the German Research Hertzler, Lauren Wolf, and Jarred Foundation. Blank is gratefully acknowledged. Looking Ahead

44 ACTIVITY 9

Formation of a Special Government Affairs Committee

See report of the Government Relations Committee (Appendix 5) copied below:

Members: Michael Hearn, Tim Rose, Michael Strem, Doris Lewis, Peter Jacobi, , Chris Moreton, Liming Shao, Pamela Nagafuji, Don Rickter, Michael Singer.

In 2007 our Section had four active participants in the ACS Joint Board-Council Committee on Chemistry and Public Affairs, Dr. Michael J.Hearn, Timothy L. Rose, Peter Jacobi and Doris Lewis. All are members of the Legislative Action Network which send letters to Congress in support of ACS positions, as are many other members of the Northeastern Section. Additionally, Mike Strem has been active in contacting his congressman, Rep. Tierney.

Dr. Rose, Dr. Jacobi, and Dr. Lewis attended the CCPA meeting April 23 and 24 in Washington, and also attended the 4th annual ACS Legislative Summit March 25-26. All were members of a team advised by ACS OLGA Staff member Ray Garant. Congressional offices visited were: Rep. Barney Frank (constituent, Doris Lewis); Marty Meehan (constituent Tim Rose); Nita Lowey(D- NY), constituent Anne O’Brien; Senator Gregg, constituent Peter Jacobi; Senator Hillary Clinton, constituent Ron Breslow; Rep. Paul Hodes, constituent Peter Jacobi. The theme for the visit was innovation and competitiveness, specifically advocating an increase in funding for basic physical science at NSF, DOE Office of Science, and NIST core; funding increase for math and science education programs proposed under the American Competitiveness Initiative at NSF and the Department of Education; and the Math and Science Partnership programs at NSF and the Department of Education. Shortly after these meetings, we were delighted to learn that The House approved H.R. 362, the 10,000 Teachers, 10 Million Minds Science and Math Scholarship Act, and by a vote of 88 to 8 the Senate passed the America Competes Act. The House Committee on Science & Technology also approved their bill to reauthorize programs at the National Science Foundation..

Dr. Hearn, Dr. Lewis, Dr. Rose, and Dr. Jacobi attended the September 10 meeting in San Francisco of CCPA and of its work groups. Dr. Rose is a member of the Policy Work Group, Dr. Lewis is a member of the Grassroots Work Group, which Dr. Hearn is chair, and Dr. Jacobi is a member of the Fellowships Work Group. In addition to the work group activities, and reports on the presidential task force and the state advocacy program, the committee was addressed by speaker Luis Echegoyen, Director, NSF Chemistry Division.

In keeping with the OLGA state advocacy program, NESACS has increased activity with the state legislature. Doris Lewis and Susan Brauner, member of the Brauner Lecture Committee, met with Casey Rose Shevin, legislative aide to Senator Robert O’Leary, Chair of the Senate Committee on Higher Education and member, Senate Committee on Environment, Natural Resources, and Agriculture. Ms. Shevin was very helpful in giving guidance on effective ways of dealing with the state legislature, giving us a number of contact names, and pleased to be made aware of the resources that NESACS could offer. We gave her current ACS fact sheets regarding science funding and outcomes in Massachusetts for the Senator’s use in supporting current innovation and competitiveness legislation in Massachusetts.

Committee member Tim Rose and NESACS Councilor Don Rickter have been active in following The Safer Alternatives Bill (An Act for a Healthy Massachusetts: Safer Alternatives to Toxic Chemicals, passed by the Massachusetts Senate on February 8). Led by Senator Steven Tolman (D-Brighton) and Senator Pam Resor (D-Acton), efforts to move the bill forward in the Senate gained momentum in the wake of last year's product recalls over hazardous ingredients such as lead in children's toys and lipstick. It is supported by the Alliance for a Healthy Tomorrow (AHT), a coalition of over 160 organizations -health, labor, scientific, environmental, 45 faith and community groups - working to promote the use of safer alternatives to toxic chemicals where feasible. ACS does not have an official position on the bill, but Dr. Rickter has kept in close touch with Bob Ross, Chief Policy Advisor for the Senate President and with his state rep, Jim Marzilli, who was elected to the state Senate in December, and has kept this committee and the NESACS board up-to-date on the progress of the bill. We have also made Caroline Trupp Gill of OLGA aware of the legislation.

46

ACTIVITY 10

Networking and fund-raising events such as golf tournaments

2007 Northeastern Section of ACS (NESACS) Fund-Raising Activities

Summary: $25,957 raised (details in Table 1)

1. Third Annual Golf-Tournament was held during ACS national meeting in Boston, August 2007. Funds came from the contributions made by companies as sponsors of holes. Each golfer paid a fee to play. ACS Women Chemist Committee was also a sponsor. 2. NESACS Vendor Fair was held March 30, 2007 at the Advances in Chemical Science Symposium in Cambridge, MA. 3. Corporate solicitation was made from current contributors (see list in Nucleus) and new scientific companies in geographical proximity to the Section. 4. NESACS YCC raised funds to support the German Exchange program. 5. Merck made a contribution to NESACS National Chemistry week program.

Dorothy J. Phillips, Chair, Fundraising Committee, thanks all organizers of the above activities.

Table 1: Contributions March 30 Adv in Chemical Science Symposium Pfizer $2,000.00 Ziopharm Oncology Inc $1,000.00 Vertex Pharmaceuticals $1,000.00 AstraZeneca $1,000.00 Royal Soc of Chemistry $750.00 Millennium Pharmaceutical $1,000.00 Novartis $2,000.00 Wyeth $500.00 Serono Repro Inst $885.00 Abbott Laboratories $2,000.00 YCC Career Day and Research Symposium Vertex Pharma $900.00 AstraZeneca $500.00 Golf Sponsors Wm Carroll $500.00 Lyophilization of NE $7,500.00 Strem Chemicals $1,000.00 PCI Synthesis $300.00 Cambridge Major Labs $500.00 Vertex Pharma $500.00 Irix Pharmaceuticals $1,000.00

47 Zink, Inc. $1,000.00 ACS Women Chemist Committee $3,695.00 National Chemistry Week Merck $2,000.00 German Exchange Program Strem Chemicals $5,000.00 Total $36,530.00 Fundraising expenses Golf Outing $10,573.07 Net $25,956.93

48

From the Nucleus

Fund Raising - Golf Tournament

The first place team! (L-R) Paul Delfino, Jim Bannister, Stu Needleman receiving their award from Harry Mandeville.

Second place team: (L-R) Damon Abernathy,Aimee Hodge and Matt Halvorsen with Harry Mandeville

49

Third place team: (L-R) Geoff Tapper, Amy Tapper, Panos Kalaritis, and Harry Mandeville

50

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 2

BUDGETS AND LONG-RANGE PLAN

Budgets and Long-Range Plan provided below -- uploaded into ACS S.O.L.A.R. report.

http://www.nesacs.org

51 52 Notes to the 2007 Budget Proposal 02/08/07 Expense accounts for which budget requests were received are shown. The "From Account" column shows the income accounts which fund the "Offset" expense budget amounts. In the places where there are two numbers, the breakdown is shown below. The budget is in deficit by $15,929 to be made up from cash on hand on December 31.

14 Contributions. This is all corporate giving to the Section. $15,000 is for line 87. 15 Other Program Income. Consists of the offsetting income from Education and YCC activities as noted in expense categories offset by account 15. 21-29 Trustees. Approval of the budget constitutes the approval to transfer the budgeted amounts from the Trust Funds for expenditures as indicated in the expense items. In addition, the National Norris Award will cost about $9,000. 52 Treasurer. $3,800 is for the CPA audits required by Massachusetts and $800 for Treasurer's expenses. 54 Consists of $3500 for a web consultant and $500 for general expenses for the site. 55 Nucleus Budget Request. (Lines 54 and 55 combined)

EXPENSE: Three 16 page issues 13134.00 Four 20 page issues 20180.00 One 24 page issue 5527.00 One 28 page issue 5979.00 National Meeting issue 13038.00 Ballots 2099.00 Ad Manager 12000.00 Business Manager, Piper Ent. 2100.00 Office & Committee expense 1400.00 Website, line 54 4000.00 79457.00 INCOME: Advertising 48000.00 Publications Trust 6000.00 Norris Award Fund (In line 67 budget) 5000.00 General Funds (55) 18457.00 79457.00 58 A new line for fundraising, primarily golf expenses. 60 Education. The Budget request was for $17,175 including $500 for May meeting expenses, $1500 for Undergraduate Day offset by $800 income, $1725 for the Student Research Conf., $1000 for Student Affiliates, $1250 for travel grants for undergraduates, $5200 for Connections to Chemistry partially offset by $2160 of registration fees, $1000 for ACS Scholars, and $5000 for the German Exchange Program. The $5000 was moved to line 87. 17,63 Continuing Education. The $1000 in these lines may be any offsetting amounts. CE has requested that we not assume any profit. 64 Dinner and AV costs 66 Hill Award. The budget funds dinners for guests at the local award plus $1000 for the NOBCChE Hill lectureship. 69 Norris Richards Research Scholars. This budget request includes 4 scholarships at $2750 plus $500 for each of the four institutions and $700 for expenses. The Norris Trust funds two of the awards. 70 Project SEED. The ACS matches student stipends, but the amount here is only the Section's share. 71 Not a medal year. 72 Includes hourly contracted secretarial services to Piper Enterprises (2006 total was $600). 76 Trustees. Includes $500 for secretarial services by Piper Enterprises. 77 Chair-elect. Travel and registration to leadership meetings. 78 National Chem Week. $2000 is budgeted from the Brauner Trust for an honorarium. 31,79 Summer Programs. As for continuing education, income should offset expenses but ticket prices should be increased to generate a profit. 80 ACS Scholarships. Fourth year of a 4 yr pledge of $2500/yr as voted in 2004. 82 Travel Grants. National pays slightly less than 75% of costs up to a specified maximum. 83 Adm. Secretary to be increased from $29 to $30hr. 86 Younger Chemists. The request includes $3500 for the April Research Conf., $6000 for a career fair, offset by $5000 of income, $300 for a Career Symposium, $8000 for German Exchange, and $1120 for other events. The $8000 was moved to line 87. 87 Jung Chemiker. $13,000 was requested, plus $8000 for YCC and $5000 for Education Committee expenses.

53 Budgets 2007 - 2008

54 Northeastern Section AMERICAN CHEMICAL SOCIETY

Administrative Secretary (MA & NH only) Phone or Fax (800) 872-2054 23 Cottage Street Phone or Fax (508) 653-6329 Natick, MA 01760 e-mail: [email protected]

JOINT MEETING BOARD OF DIRECTORS & LONG-RANGE PLANNING

NORTHEASTERN SECTION, ACS LONG-RANGE PLANNING MEETING Tuesday, September 25, 2007 4:30 p.m. Wellesley College Club - Wellesley, MA

AGENDA ITEMS SUGGESTED BY BOARD MEMBERS:

Mukund Chorghade:  Special Symposia and events: Symposia on Drug Development, annual meetings-NESACS, RSC and IUPAC co- sponsored  Science Café (two or three times a year); career services presentations, work with high-schools (tutoring and e- tutoring etc)  Fund-raising; internships for students  Incorporation of special interest groups-BAGIM, Drug Development

Myke Simon:  Finding a new Archivist (from Myke Simon)  Providing for a transfer of responsibility to younger members of NESACS

Don Rickter:  I am concerned with getting greater participation by the membership at large. How do we entice chemists to get involved? We could name some tasks and ask for volunteers to join a task force. Ethics Issues  Anyone interested in the history of chemistry could help with the archives or start a project to have the first National Historical Landmark in Massachusetts. o (The Northeastern Section has only one NHCL, the one at the University of New Hampshire). It is amazing that there is no NHCL at Harvard or MIT or any other of the pioneering schools and corporations.

55 JOINT MEETING BOARD OF DIRECTORS & LONG-RANGE PLANNING Tuesday, September 25, 2007 Mukund Chorghade, Chair, presiding 4:30 p.m.

AGENDA

A. Approval of Minutes B. Reports from Officers Chair...... Mukund Chorghade Chair-Elect (Program Committee)...... Marietta Schwartz Secretary...... Michael Singer Treasurer ...... Jim Piper Archivist...... Myke Simon C. Report from Trustees D. Report from Councilors E. Reports from STANDING Committees Local Arrangements...... Mary Burgess Chemical Education...... Ruth Tanner Board of Publications...... Vivian Walworth Nucleus Editor ...... Mike Filosa Constitution/By-laws ...... Cathy Costello Membership...... Michaeline Chen Nominations ...... Pam Mabrouk Professional Relations/Career Service ...... Mukund Chorghade F. Reports from SPECIAL Committees Awards ...... Mike Dube Continuing Education ...... Al Viola Esselen Award Committee ...... Robert Langer Fund-raising Committee...... Dorothy Phillips Medicinal Chemistry Group...... Liming Shao/Raj Rajur National Chemistry Week ...... Christine Jaworek-Lopes National Meeting – Boston...... Bob Lichter Norris Award Committee...... Donald Smith NERM...... Mort Hoffman Involvement of the Section in the Northeast Region awards program (See attached poster) . Project SEED...... Pam Mabrouk Richards Award...... Gary Weisman Speakers' Bureau...... Jin Ji Summerthing ...... Doris Lewis Women Chemists...... Pam Mabrouk YCC ...... Lalia Dafik G. Old Business H. New Business I. Adjournment

56

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 3

MEMBERSHIP SURVEYS AND NEWSLETTER

http://www.nesacs.org

A. Membership Survey Conducted in 2007

No membership survey was conducted in 2007

B. 2007 Newsletter

The Summer 2007 issue of The Nucleus was uploaded into the ACS SOLAR report.

57

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 4

PUBLIC RELATIONS PLAN TALKS TO PUBLIC NEWSPAPER CLIPPINGS

No Public Relations Plan was prepared in 2007 Newspaper Clippings are not available for this report

http://www.nesacs.org

58 TALKS TO PUBLIC The list below includes only those talks by NESACS members that were publicized in The Nucleus or submitted to the NESACS office for distribution via e-mail and/or filing.

Many other NESACS members gave talks to the public that are not included in the following list.

Date Speaker / Affiliation Location Topic 11-Jan Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) Saurashtra U., Rajkot Value Creation: Collaboration with worldwide laboratories: Process Development and Project Management of Technology Transfer Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 16-Jan Chair) Pune Univ., India Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 29-Jan Chair) Pfizer / Cambridge, MA 30-Jan Prof Gregory Petsko (Brandeis Univ.) Boston College Structural Neurology: A New Approach to the Understanding, Treatment and Prevention of Neurodegerative Diseases 31-Jan Dr. Elena Rybak-Akimova (Tufts University) Umass Dartmouth TBA Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 31-Jan Chair) Howard U, Washington DC 3-Feb Prof. Stephen Lippard (MIT) Tufts University Boston Regional Inorganic Meeting (BRIC) 3-Feb Prof. Roy Planalp (Univ. New Hampshire) Tufts University Boston Regional Inorganic Meeting (BRIC) 6-Feb Prof. Timothy M. Swager (MIT) Boston College TBA Feb-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) Anrangabad, India Value Creation & Opportunities in Medicinal Chemistry: Collaborations in Drug Discovery, Process Development and Project Management of TechnologyTransfer 21-Feb Dr. Michele Mandrioli (Umass Dartmouth) Umass Dartmouth Some Applications of WebCT Features in Face-to-Face Courses 28-Feb Dr. Linda H. Doerrer (Boston University Umass Dartmouth MetallophilicInteractions in Precious Metal PolyimineDouble Salts 5-Mar Dr. Sunney Xie (Harvard University) Boston College Holding Single Molecules Up to the Light: From In Vitro to In Vivo Investigations in Biophysical Chemistry 7-Mar Dr. Edward Wong (University of New Hampshire) Umass Dartmouth Cross-bridged Tetrasmines, the Sequel 20-Mar Dr. Scott Schaus (Boston University) UNH TBA 21-Mar Prof. Richard R. Schrock (MIT) Boston College The Discovery & Development of High Oxidation State Catalysts for the Metathesis of Alkenes and Alkynes 22-Mar Prof. Richard R. Schrock (MIT) Boston College Applications of High Oxidation State Metathesis Catalysts in Organic and Polymer Chemistry

59 23-Mar Prof. Richard R. Schrock (MIT) Boston College Catalytic Reduction of Dinitrogen to Ammonia with Protons and Electrons 30-Mar Prof. Eric Jacobson (Harvard University) Royal Sonesta/Cambridge Symposium: Advances in Chemical Sciences Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 19-Apr Chair) Univ. of Toledo, OH 5-May Prof. Dean E. Wilcox (Dartmouth College) UNH TBA 5-May Dr. Dean E. Wilcox (Dartmouth College) UNH BRIC Meeting / Boston Regional 17- May Norton Peet (Int'l Consultant / No. Andover, MA) Holiday Inn/Woburn MGC Symposium / Moderator 17- May Neal Green (Wyeth Research / Cambridge, MA) Holiday Inn/Woburn Inhibitors of Tp12 Kinase & TNF Production: Selectivity and In Vivo Anti-inflammatory Activity of Novel 8- Substituted-4-anilino-6-aminoquinoline-3-carbonitriles 17- May Mark T. Goulet (Merck Research Labs / Boston, MA) Holiday Inn/Woburn Lead Optimization of Orally Bioavailable Drugs Jul-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) Protecting Group Directed Ring Closing Metatheses (RCM): First Pasadena, CA Total Synthesis of theAnti-Malarial Nonenolide Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 17-Jul Chair) Schering-Plough, NJ Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) IUPAC/Torino, Italy IUPAC General Assembly: Chemistry and Human Health Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) IUPAC/Torino, Italy IUPAC Div. VII Subcommittee on Medicinal Chemistry & Drug Dev. Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) IUPAC/Torino, Italy IUPAC Div. VII Subcommittee on Nomenclature, Properties and Units in Laboratory Measurement Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) IUPAC/Torino, Italy IUPAC Div. VII Subcommittee on Toxicology& Risk Assessment Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) ACS Meeting/Boston The Role of Cultural Diversityon Global Teams Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) ACS Meeting/Boston Globalization in the Progression of a Drug from Conception to Commercialization: Opportunities and Challenges for Strategic Collaboration Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) ACS Meeting/Boston Changing Landscapes of the Biopharma-Industry: Multidisciplinary Nature of Biotech and How that Affects the Job Market Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) ACS Meeting/Boston Ted & ArleneLight: Careers of Service to the Profession Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) ACS Meeting/Boston A Short and Efficient SyntheticStrategy for (S)- and ®-Plakolide A Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) ACS Meeting/Boston Protecting Group Directed Ring Closing Metatheses (RCM): First

60 Total Synthesis of theAnti-Malarial Nonenolide Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) St. Petersburg, Russia Protecting Group Directed Ring Closing Metatheses (RCM): First Total Synthesis of theAnti-Malarial Nonenolide Aug-07 Mukund S. Chorghade (Chorghade Enterprises / NESACS Chair) St. Petersburg, Russia Route Selection & Process Development for a Magnetic Resonance Imaging (MRI) Contrast Agent 19-Aug Dr. Morton Z. Hoffman (Boston University emeritus) Seaport Hotel/Boston Exploring the High School - College Interface 19-Aug Laila Dafik (YCC Chair, NESACS) Seaport Hotel/Boston Study Abroad Opportunities in Germany for American Science & Engineering Undergraduates 19-Aug Dr. Morton Z. Hoffman (Boston University emeritus) Seaport Hotel/Boston Symposium: Connections to Germany -- Research & Education Opportunities 21-Aug Dr. Michael Hurrey (Vertex Pharmaceuticals) ACS Meeting/Boston Symposium Moderator: Changing Landscapes of the BioPharma Industry 21-Aug Dr. Mukund S. Chorghade (Chorghade Enterprises) ACS Meeting/Boston Multi-disciplinary Nature of Biotechnology and Its Effect on the Job Market 21-Aug Dr. Mukund S. Chorghade (Chorghade Enterprises) ACS Meeting/Boston Moderator: Professional Relations 21-Aug Dr. Daniel Eustace (NESACS) ACS Meeting/Boston Multi-Layer Coating Technologies 21-Aug Dr. Dudley Herschbach (Harvard University emeritus) ACS Meeting/Boston Developing the Next Generation of Chemists 21-Aug Dr. Morton Z. Hoffman (Boston University emeritus) ACS Meeting/Boston Awards Dinner: The Time of Your Life 22-Aug Dr. Pam Mabrouk (Northeastern University) ACS Meeting/Boston Symposium: Sisters in Science - Moderator 22-Aug Dr. Esther Hopkins (NESACS Board) ACS Meeting/Boston Sisters in Science: A Certain Restlessness 22-Aug Dr. Dorothy J. Phillips (Waters Corp. & NESACS) ACS Meeting/Boston Sisters in Science: Roads that Unite R&D & Business Careers 17-Sep Prof. Russell P. Hughes (Dartmouth College) Boston University Facile Activation of Carbon-Fluorine Bonds: Inner Sphere Construction of New Fluorinated Organic Ligands 17-Sep Dr. Gerband Ceder (MIT) Northeastern Univ. TBA 20-Sep Greg Cuny (Harvard Medical School) Holiday Inn/Woburn Opportunities and Challenges for Medicinal Chemistry in Academic Drug Discovery Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 21-Sep Chair) U. Wisconsin, Madison 3-Oct Dr. Peter Caravan (Mass. General Hospital) Umass Dartmouth Molecular MRI - from Bench to Bedside 16-Oct Dr. William Armstrong (Boston College) Umass Dartmouth Insight into Photosynthesis by Making Use of Synthetic Inorganic Chemistry

61 17-Oct Steve Lantos (Brookline High School) Burlington H.S. Connections to Chemistry: The Chemistry in Discrepant Events: They're Not What You Think! 17-Oct John Duffy (University of Mass Lowell) Burlington H.S. Fuels from Renewable Sources 17-Oct Dr. Mukund S. Chorghade (Chorghade Enterprises) Burlington H.S. The Chemistry Is Right 17-Oct Dr. David Cunningham (NESACS Webmaster) Burlington H.S. Team Science 18-Oct Dr. Mukund S. Chorghade (Chorghade Enterprises) Umass Boston Progression of a Drug from Test Tube to Clinic: A Personal Adventure 21-Oct Dr. Bassam Shakhashiri (U. Wisconsin) Museum of Science Boston Brauner Lecture: The Many Faces of Chemistry 24-Oct Dr. T. W. Swager (MIT) Umass Dartmouth Polymer Electronics for Ultra-Sensitive Chemical Sensors Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 29-Oct Chair) Palatin Tech., NJ Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 31-Oct Chair) Entremed, MD Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 31-Oct Chair) Amulet Pharm./ MD 1-Nov Dr. David A. Weitz (Harvard University) Harvard University Dripping Jetting Drops and Wetting: The Magic of Microfluidics 13-Nov Prof. Catherine Drennan (MIT) Boston College Structural Insights into Enzymatic Halogenation of Natural Products 14-Nov Dr. Christopher Walsh (Harvard Medical School) Northeastern Univ. Natural Product Enzymatic Assembly Lines: Logic & Machinery 3-Dec Mr. Mohammad Movassaghi (MIT) Boston University Cascade Reactions in Complex Alkaloid Synthesis Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 7-Dec Chair) Indoco Rem./Mumbai, India 10-Dec Dr. Klavs Jensen (MIT) Tufts University TBA 12-Dec Norton Peet (Int'l Consultant / No. Andover, MA) Holiday Inn/Woburn MGC Symposium / Moderator 12-Dec Vinod F. Patel (Amgen, Inc. / Cambridge, MA) Holiday Inn/Woburn The Discovery of Motesanib (AMG706), a Multi-Kinase Angiogensis Inhibitor for Treatment of Human Cancers: From Crystal to Clinic Dr. Mukund S. Chorghade (Chorghade Enterprises/NESACS 21-Dec Chair) Schering-Plough, Camb., MA

62

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5

AS NEEDED BY SECTION NESACS REPORTS

http://www.nesacs.org

63

NORTHEASTERN SECTION OFFICERS / COUNCILORS / CHAIRS -- 2007

Chair Dr. Mukund S. Chorghade 14 Carlson Circle, Natick, MA 01760 (P) 508-651-7809 (F) 508-651-7920 [email protected]

Chair-elect Dr. Marietta Schwartz Chemistry Department, University of Mass. Boston, Boston, MA 02125-3393 (P) 617-287-6146 [email protected]

Past-Chair Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Secretary Dr. Michael Singer Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x291 (F) 508-655-1359 [email protected]

Treasurer Dr. James U. Piper 19 Mill Road, Harvard, MA 01451 (P) 978-456-8622 (F) 978-456-8949 [email protected]

Auditor Dr. Anthony L. Rosner 1443 Beacon Street, Apt. No. 201, Brookline, MA 02446 (P) 703-276-7455 (F) 703-276-8178 [email protected]

Trustee Dr. Esther A. H. Hopkins 1550 Worcester Road, Unit 309, Framingham, MA 01702 (P) 508-872-8148 [email protected]

Trustee Mr. Joseph A. Lima 11 Morningside Avenue, Natick, MA 01760 (P) 617-244-5764 (F) 617-254-2713 [email protected]

Trustee Dr. Michael E. Strem Strem Chemicals, Inc., 7 Mulliken Way, Newburyport, MA 01950 (P) 978-499-1600 [email protected]

Councilor Miss Mary Burgess 63 Weld Hill Street, Boston, MA 02130-4150 (P) 617-522-9165 [email protected]

Councilor Mrs. Michaeline Chen 529 Grove Street, Needham, MA 02492 (P) 781-235-5201 [email protected]

64

Councilor Dr. Catherine Costello B. U. School of Medicine, 715 Albany Street R-806, Boston, MA 02118-2394 (P) 617-638-6490 (F) 617-638-6491 [email protected]

Councilor Dr. Thomas Gilbert Chemistry Department, Northeastern University, Boston, MA 02115 (P) 617-373-4505 (F) 617-373-8795 [email protected]

Councilor Dr. Michael J. Hearn Chemistry Department, Wellesley College, Wellesley, MA 02481 (P) 781-283-3127 (F) 781-283-3642 [email protected]

Councilor Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Councilor Dr. Christine Jaworek-Lopes Emmanuel College, 400 The Fenway, Boston, MA 02115 (P) 617-264-7614 [email protected]

Councilor Dr. Doris I. Lewis 236 Lexington Street, Newton, MA 02466 (P) 617-573-8546 (F) 617-573-8668 [email protected]

Councilor Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Councilor Pamela Nagafuji 354 Broadway, #2, Cambridge, MA 02139 (H) 781-910-0625 [email protected]

Councilor Dr. Dorothy J. Phillips 10 Lamplight Circle, Natick, MA 01760 (P) 508-482-2860 (F) 508-482-3100 [email protected]

Councilor Dr. Donald O. Rickter 88 Hemlock Street, Arlington, MA 02474 (P) 781-643-7575 [email protected]

Councilor Dr. Michael Singer Sigma-RBI, 1 Strathmore Road, Natick, MA 01760 (P) 508-651-8151 x291 (F) 508-655-1359 [email protected]

Councilor Dr. Amy Tapper 182 Beacon St., #11, Boston, MA 02116

65 (H) 617-421-1986 [email protected]

Alternate Councilor Ms. Eva B. Binnun P. O. Box 198, Melvin Village, NH 03850 (P) 617-665-5646 [email protected]

Alternate Councilor Dr. Michael Filosa 18 Tamarack Road, Medfield, MA 02052-1816 (P) 781-386-8479 [email protected]

Alternate Councilor Dr. Timothy B. Frigo Advanced Magnetics, Inc., 61 Mooney Street, Cambridge, MA 02138 (P) 617-497-2070 (F) 617-547-2445 [email protected]

Alternate Councilor Dr. Mark Froimowitz 90 Eastbourne Road, Newton, MA 02459-1206 (P) 617-732-2851 [email protected]

Alternate Councilor Dr. Patrick M. Gordon 1 Brae Circle, Woburn, MA 01801-2222 (P) 781-932-0169 [email protected]

Alternate Councilor Dr. Barney Grubbs Chemistry Dept., Dartmouth College, Hanover, NH 03755 (P) 603-646-33519096 [email protected]

Alternate Councilor Dr. Jerry P. Jasinski Chemistry Dept., Keene State College, Keene, NH 03435 (P) 603-358-2563 [email protected]

Alternate Councilor Mrs. Arlene W. Light 85C Seminary Avenue, Lasell Village, Apt. 239, Auburndale, MA 02466-0260 (P) 617-244-5764 [email protected]

Alternate Councilor Dr. Mary A. Mahaney 12 Commonwealth Avenue, Dedham, MA 02026-1435 (P) 617-577-5541 [email protected]

Alternate Councilor Dr. Julia Miwa Chemistry Dept., Wellesley College, Wellesley, MA 02481-8203 (P) 781-283-3128 (F) 781-283-3642 [email protected]

Alternate Councilor Dr. S. B. Rajur 5 Keystone Way Andover, MA 01810 (P) 781-938-1122 : [email protected]

66 Alternate Councilor Dr. Lawrence T. Scott Chemistry Department, Boston College, Chestnut Hill, MA 02467 (P) 617-552-8024 [email protected]

Alternate Councilor Dr. Liming Shao Sepracor, Inc., 85 Waterford Drive, Marlborough, MA 01752 (P) 508-357-7468 [email protected]

Alternate Councilor Dr. Alfred Viola 14 Glover Road, Wayland, MA 01778 (P) 508-358-7222 [email protected]

Director-at-Large Dr. Cassandra Celatka Genzyme, 153 Second Street, Waltham, MA 02451 (P) 781-434-3540 [email protected]

Director-at-Large Dr. Ernest V. Groman 80 Columbia Street., Brookline, MA 02446 (P) 617-738-8501 [email protected]

Director-at-Large Dr. Graham B. Jones Northeastern University, 102 Hurtig, 360 Huntington Ave., Boston, MA 02115 (P) 617-373-2822 [email protected]

Director-at-Large Stephen Lantos 22 McTernan Street, Cambridge, MA 02139 (P) 617-491-3637 (F) 617-730-2635 [email protected]

Director-at-Large Dr. Gary R. Weisman Dept. of Chemistry, University of New Hampshire, Durham, NH 03824 (P) 603-862-2304 [email protected]

Archivist Dr. Myron S. Simon 20 Somerset Road, West Newton, MA 02465-2722 (P) 617-332-5273 [email protected]

Awards Chair Dr. Michael J. Dube Nye, Inc., P. O. Box 8927, New Bedford, MA 02742-8927 (P) 508-996-6721 (F) 508-997-5285 [email protected]

Board of Pubs. Chair Mrs. Vivian K. Walworth 215 Valley Road, Concord, MA 01742 (H) 978-369-3735 [email protected]

Budget Chair Dr. James U. Piper 19 Mill Road, Harvard, MA 01451 (P) 978-456-8622 (F) 978-456-8949

67 [email protected]

Chem. Ed. Chair Dr. Ruth Tanner Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854 (P) 978-934-3662 (F) 978-934-2013 [email protected]

Const./Bylaws Chair Dr. Catherine Costello B. U. School of Medicine, 715 Albany Street R-806, Boston, MA 02118-2394 (P) 617-638-6490 (F) 617-638-6491 [email protected]

Continuing Ed. Chair Dr. Alfred Viola 14 Glover Road, Wayland, MA 01778 (P) 508-358-7222 [email protected]

Corporate Funding Dr. Dorothy J. Phillips 10 Lamplight Circle, Natick, MA 01760 (P) 508-482-2860 (F) 508-482-3100 [email protected]

Esselen Chair Dr. Robert Langer MIT Dept. of Chem. Engr., 77 Mass Ave., E25 342, Cambridge, MA 02139 (P) 617-253-3107 [email protected]

Local Arrangements Miss Mary Burgess 63 Weld Hill Street, Boston, MA 02130-4150 (P) 617-522-9165 [email protected]

Med. Chem. Rep. Dr. S. B. Rajur 5 Keystone Way, Andover, MA 01810 (P) 978-764-7068 [email protected]

Med. Chem. Rep Dr. Liming Shao Sepracor, Inc., 85 Waterford Drive, Marlborough, MA 01752 (Q) 508-357-7468 [email protected]

Membership Chair Mrs. Michaeline Chen 529 Grove Street, Needham, MA 02492 (P) 781-235-5201 [email protected]

NCW Chair Dr. Christine Jaworek-Lopes Emmanuel College, 400 The Fenway, Boston, MA 02115 (P) 617-264-7614 [email protected]

NERM Chair Dr. Morton Z. Hoffman Chemistry Department, Boston University, Boston, MA 02215-2507 (P) 617-353-2494 (F) 617-353-6466 [email protected]

Nominations Chair Dr. Patricia A. Mabrouk

68 Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Norris Award Chair Dr. Marietta Schwartz Campus Center 2/2100, University of Mass. Boston, Boston, MA 02125-3393 (P) 617-287-6330 [email protected]

Nucleus / Editor Dr. Michael Filosa 18 Tamarack Road, Medfield, MA 02052-1816 (P) 781-386-8479 [email protected]

Prof. Relations/ Dr. Mukund S. Chorghade Career Service 14 Carlson Circle, Nqtick, MA 01760 (P) 508-651-7809 (F) 508-651-7920 [email protected]

Program Chair Dr. Marietta Schwartz Chemistry Department, University of Mass. Boston, Boston, MA 02125-3393 (P) 617-287-6146 [email protected]

Project SEED Chair Dr. Patricia A. Mabrouk Department of Chemistry, Northeastern University, Boston, MA 02115 (P) 617-373-2845 (F) 617-373-8795 [email protected]

Bd. Of Pubs. Chair Mrs. Vivian Walworth 215 Valley Road, Concord, MA 01742 (H) 978-369-3735 [email protected]

Richards Medal Chair Dr. Gary R. Weisman Dept. of Chemistry, University of New Hampshire, Durham, NH 03824 (P) 603-862-2304 [email protected]

Senior Chemists Chair Mr. Charles J. Bardsley 61 Harrison Avenue, Braintree, MA 02184-4911 (P) 781-843-6604 [email protected]

Trustee Dr. Esther A. H. Hopkins 1550 Worcester Rd., Unit 310, Framingham, MA 01702 (H) 508-872-8148 [email protected]

Trustee Mr. Joseph A. Lima 11 Morningside Avenue, Natick, MA 01760 (W) 617-254-1010 [email protected]

Trustee Dr. Michael E. Strem Strem Chemicals, Inc., 7 Mulliken Way, Newburyport, MA 01950 (W) 978-499-1600 [email protected]

69

Webmaster Dr. David Cunningham P. O. Box 851, No. Andover, MA 01845 (H) 617-840-8300 [email protected] , YCC Chair Laila Davik Chem. Dept., Tufts University, 62 Talbot Ave., Medford, MA 02155 (P) 617-627-2558 [email protected]

70 NESACS CALENDAR OF ACTIVITIES - 2007

Date Activity

January 18 Monthly Meeting - Harvard Faculty Club Joint meeting with Boston Area Group for Informatics and Modeling (BAGIM) Dr. Yvonne Connolly Martin, Sr. Research Fellow (retired), Volwiler Societty. Abbott Laboratories Topic: Lessons from 41 Years as a Computational Chemist February 2007 Call for Nominations: Philip Memorial Prize for Graduate Students February 8 Monthly Meeting – Harvard Faculty Club, Cambridge, MA Jeannette Elizabeth Brown, Educational Consultant Topic: African-American Women Chemists Who Made a Difference March 2007 Call for Nominations: Norris-Richards Undergraduate Summer Research Scholarships March 2007 Call for Participants and Sponsors: 3rd Annual Golf Tournament to take place in August March 2007 Call for Nominations: 2007 Northeast Regional Awards March 8 Monthly Meeting - University of Massachusetts Boston Prof. Michael R. Wasielewski, (Recipient of ACS Norris Organic Chemistry Award) Topic: Charge and Spin Transport Dynamics in Bio-inspired Molecules: From Photosynthesis to Organic Electronics April 2007 Call for Papers: Northeast Student Chemistry Research Conference (NSCRC) April 2007 Call for Volunteers: To assist at the ACS National Meeting in Boston - Summer 2007 April 2007 Summerthing 2007 Baseball Game announced April 2007 Candidates for NESACS Elections announced April 12 Monthly Meeting - Harvard University Gustavus John Esselen Award Dr. Michael A. Marletta, University of California, Berkeley Topic: Nitric Oxide in Biology: From Discovery to Therapeutics April 13 NOVA Documentary on Dr. Percy Julian at Bridgewater State College April 21 Northeast Student Chemistry Research Conference IX held at MI^ May 2007 Call for Applications: Lyman C. Newell Grants for Secondary Teachers to attend NEACT Conference May 2007 NESACS Elections conducted; ballots due by June 1 May 10 Monthly Meetng / Education Awards - Northeastern University Dr, Steve Jones, Sepracor, Inc. Topic: The Interplay of Chemistry and Biology Presentation of Awards: Philip L. Levins Memorial Prize Norris/Richards Undergraduate Research Fellowships Undergraduate Grants-in-Aid Project SEED Certificates Richards Secondary Teaching Awards Aula Laudis Society - Induction of Members Ashdown Examination Prizes Simmons College Prize Phyllis A. Brauner Memorial Book Award

May 17 Medicinal Chemistry Symposium Topic: Lead Optimization Strategies Speakers: Norton Peet, International Consultant, No. Andover, MA Introductory Remarks Prof. L.V.G. Nargund, Nargund Research Foundation Nargund College of Pharmacy, Bangalore, India, Green Chenistry: Synthesis of Small Molecules by Microwave Technique Neal Green, Wyeth Research, Cambridge, MA Inhibitors of Tp12 Kinase and TNF Production: Selectivity and In Vivo Anti-inflammatory Activity of Novel 8-Substituted-4-anilino-6-aminoquinoline-3-carbonitriles Mark T. Goulet, Merck Research Laboratories, Boston, MA Lead Optimization of Orally Bioavailable Drugs Horst Hemmerle, Discovery Chemistry, Eli Lilly and Co., Indianapolis, IN Use of Rllevant Chenical Diversity in Drug Discovery

71 Summer 2007 Special National Meeting Issue of The Nucleus published Summer 2007 NESACS Election Results published Summer 2007 Award Recipient announced / Prof. Diane M. Bunce, Catholic University of America Summer 2007 Call for Nominations: Richards Medal Award July 14 Summerthing: Lowell Spinners (Red Sox Single A) vs. Auburn Doubledays ( Blue Jays Single A) August 2007 ACS National Meeting held in Boston Aug. 19: Division of Chemical Education - High School Program Keynote Speaker: Dr. Morton Z. Hoffman “Exploring th High School-College Interface” Aug. 19: Division of Chemical Education - Symposium Connections to Germany: Research and Education Opportunities Featuring NESACS’ German Exchange Program Aug. 19: Reception highlighting NESACS’ activities Aug. 21: YCC and Division of Business Management Symposium “Changing Landscapes of the BioPharma Industry” Featuring NESACS members Michael Hurrey, Patrick Connelly, Mukund S. Chorghade Aug. 21: Division of Professional Relations Symposium in honor of NESACS members Ted and Arlene Light Aug. 22 Division of Professional Relations Symposium “Sisters in Science” organized by NESACS member, Pam Mabrouk August 18-25 NESACS Exchange Program with Germany conducted during ACS National Meeting, including a Symposium, Reception, and Poster Display on August 19 and Exchange Dinner on August 24 August 21 NESACS is finalist in 6 ChemLuminary Categories / wins 3 ChemLuminary Awards at ACS National Meeting August 22 Golf Tournament - Brookline Golf Club at Putterham Meadows September 2007 Call for Nominations: Gustavus John Esselen Award for Chemistry in the Public Interest September 2007 Call for Nominations: Richards Medal Award September 2007 Call for Applications: Grants-in-Aid to Undergraduates to attend 2008 National Meeting / New Orleans September 20 Monthly Meeting – Joint meeting with Medicinal Chemistry Group Medicinal Chemistry Group Symposium – Holiday Inn Select Hotel, Woburn, MA Topic: Building Bridges between the Pharmaceutical Industry and Academia -- A New Paradigm for Drug Discovery Moderator: Dr. Tom Large, VP-Drug Discovery, Sepracor, Inc. Speakers : David Weaver, Director, New Leads Discovery, Vanderbilt University New Frontiers in Exploratory and Early Drug Discovery Research: A Hybrid Academic/Industrial Approach Greg Cuny, Director, Laboratory for Drug Discovery in Neurodegeneration, Harvard Medical School Opportunities and Challenges for Medicinal Chemistry in Academic Drug Discovery Perry F. Renshaw, M.D., McLean Hospital Brain Imaging Center, Harvard University In Vivo Magnetic Resonance Spectroscopy in Drug Discovery and Development Iwao Ojima, Professor & Director, Institute of Chemical Biology & Drug Discovery, SUNY at Stony Brook Opportunities for Translational Research in Chemical Biology and Drug Discovery October 2007 Call for Applications: YCC/NESACS--JCF/GDCh Exchange to Germany - 2008 October 2007 Call for Abstracts: 6th Annual New England Environmental Research Symposium October 2007 Annual Nucleus Buyers Guide published in Nucleus October 18 Monthly Meeting – University of Massachusetts Boston Henry A. Hill Award for Outstanding Service to the Northeastern Section to Dr. Ruth Tanner 50-Year Members of ACS presented certificates of recognition Dr. Mukund S. Chorghade, President, Chorghade Enterprises / THINQ Pharma Topic: Progression of a Drug from Test Tube to Clinic: A Personal Adventure October 2007 National Chemistry Week Activities Sept 15-Oct 10 - K-12 Poster Competition Oct. 21 - Museum of Science boston Phyllis A. Brauner Memorial Lecture by Dr. Bassam Shakhashiri Kicking off NCW 2007 Festivities Oct. 27 - Boston Children’s Museum Demonstrations and hands-on activities related to the yearly theme Oct. 21-27 - Grades 1-12 puzzle Contest October 18-NCW Connections to Chemistry - High School Teacher Workshop - Burlington (MA) High School Workshop A: The Chemistry in Discrepant Events: They’re Not What You Think! with Steve Lantos,

72 Brookline High School Chemistry Teacher Workshop B: Fuels from Renewable Sources with John Duffy, Mechanical Engineer, University of Massachusetts Lowell Workshop C: The Chemistry Is Right with Mukund S. Chorghade, President, Chorghade Enterprises / THINQ Pharma Workshop D: Chemistry Beyond the Classroom with Terry Taylor, Manager, Office of High School Chemistry, Education Division, ACS Workshop E: Tean Science with David Cunningham, NESACS Webmaster Dinner Speaker: Lori Krim Gavrin, Research Science, Chemical & Screening Sciences, Wyeth Research Address: Drug Design from Bench Top to Bedside November 8 Monthly Meeting / Harvard University James Flack Norris Award Dinner & Program Prof. Diane M. Bunce, The Catholic University of America, Award Recipient and Speaker Topic: “Teaching Is More than Lecturing and Learning Is More than Memorizing” November 10 Sixth Annual Environmental Research Symposium / Bridgewater State College Co-sponsored by NESACS with Bridgewater State College December 2007 New NESACS web site online December 2007 Call for Nominations - Norris Award (Outstanding Achievement in the Teaching of Chemistry) December 2007 Call for Nominations - Levins Memorial Prize (Graduate Student) December 12 Monthly Meeting – Joint meeting with Medicinal Chemistry Group Medicinal Chemistry Group Symposium – Holiday Inn Select Hotel, Woburn, MA Topic: Signal Transduction Targets and Drug Discovery Moderator: Dr. Norton Peet, International Consultant, No. Andover, MA Speakers: Hariprasad Vankayalapati, Director of Medicinal Chemistry, SuperGen, Inc., Salt Lake City, UT Discovery of MP-529: A Selective Inhibitor of Aurora 2 Kinase in Development for the Treatment of Cancer Adrian D. Hobson, Group Leader, Hit-to-Lead Medicinal Chemistry, Abbott Bioresearch Ctr., Worcester, MA Applications of Parallel Synthesis in Hit-to-Lead Vinod F. Patel, Director of Medicinal Chemistry, Amgen, Inc., Cambridge, MA The Discovery of Motesanib (AMG 706), a Multi-Kinase Angiogensis Inhibitor for Treatment of Human Cancers: From Crystal to Clinic Tomi Sawyer, Chief Scientific Officer & Sr. VP of Drug Discovery, Aileron Therapeutics, Cambridge, MA Exploring Chemical Space in Protein-Protein Interaction Drug Discovery: Bridging Nature to Breakthrough Medicines

REPORT OF THE ARCHIVIST - 2007 Myron S. Simon, Ph.D., Archivist

The June resignation of the current archivist has failed to cause any change in the situation of the archives in 2007. At an unguarded moment the archivist was heard to say that he would stay on until a replacement could be found. He is still waiting,

The materials of importance for maintaining the history of the Section have been accumulating and are presently waiting to be brought to the location at Regis College, and used to instruct the new archivist in his or her duties. A few requests for information from the archives were answered, but no significant amount of filing has been done.

Respectfully submitted, Myron S. Simon, Archivist RTW* *Resigned to waiting.

73 REPORT OF THE AWARDS COMMITTEE - 2007 Michael J. Dube, Chair

The responsibility of the Awards Committee for NESACS includes the presentation of two awards issued by the Section. These awards include the Henry A. Hill Award and the Phillip Levins Prize.

The former is awarded to a member of the Northeastern Section for meritorious service. This year the award was presented to Dr. Ruth Tanner. This award was presented at the October local section meeting.

The Levins Prize is awarded to a graduate student demonstrating superior achievement. This year, the award was given to Yuejuan Lin from the University of Massachusetts Dartmouth under the direction of Dr. Yuegang Zuo

Respectfully submitted, Michael J. Dube, Ph.D. Chair, NESACS Awards Committee

Call for Nominations Philip L. Levins Memorial Prize Nominations may be made by a faculty member, or the Nominations for the Philip L. Levins Memorial Prize for student may submit an application. A biographical sketch, outstanding performance by a graduate student on the way transcripts of graduate and undergraduate grades, a description to a career in chemical science should be sent to the Executive of present research activity and three references must be Secretary, NESACS, 23 Cottage St., Natick, MA 01760 included. The nomination should be specific concerning the by March 1, 2007. contribution the student has made to the research and The graduate student’s research should be in the area of publications organic analytical chemistry and may include other areas of (if any) with multiple authors. organic analytical chemistry such as environmental analysis, The award will be presented at the May 2007 Section Meeting. biochemical analysis, or polymer analysis.

74

NORTHEASTERN SECTION PROGRAM

of the Marietta Schwartz Chair-elect, Northeastern Section, presiding University of Massachusetts Boston AMERICAN CHEMICAL SOCIETY

THE HENRY A. HILL AWARD

Welcome Marietta Schwartz University of Massachusetts Boston

Presentation of the Hill Award Michael J. Dube Chair, NESACS Awards Committee

Henry A. Hill Award Anthony Cromwell Hill

Introduction . Award Recipient Mukund Chorghade

Presentation of the Acceptance Ruth Tanner

Twenty-eighth RECOGNITION OF FIFTY-YEAR MEMBERS HENRY A. HILL MEMORIAL AWARD for Presentation of 50-Year Certificates and Recognition Outstanding Contribution of 60-Year Member Mukund Chorghade

to the Northeastern Section ADDRESS

to "Progression of a drug from test tube to clinic: A personal adventure” Ruth Tanner Dr. Mukund S. Chorghade Thursday, October 18 President, Chorghade Enterprises / THINQ Pharma Two thousand seven University Dining Club University of Massachusetts Boston

75

Henry Aaron Hill

PRIOR RECIPIENTS of the This month we are honoring the memory of Henry A. Hill HENRY A. HILL MEMORIAL AWARD by giving awards in his name to one of our Section for Outstanding Contribution to the Northeastern members for meritorious service to the Northeastern Section. Section Who was Henry A. Hill?

Henry A. Hill (posthumously) ...... 1980 Henry Hill was Chairman of our Section in 1963. He was Edward R. Atkinson...... 1981 very active in the national ACS, and served as a member of Robert D. Eddy ...... 1982 and chairman of several of its committees. His service on Arnet L. Powell (posthumously) ...... 1983 the Professional Relations Committee was especially G. Richard Handrick ...... 1984 notable where he drafted the Professional Employment Janet S. Perkins...... 1984 Guidelines. He was Director of the ACS in 1971-1975, was Phyllis A. Brauner...... 1985 elected President-elect and became President in 1976. Arno H. A. Heyn ...... 1986 Sr. Magdalen Julie Wallace (posthumously) ...... 1987 Born in St. Joseph, Missouri, he obtained a bachelor's Esther A. H. Hopkins...... 1988 degree from Johnson C. Smith University, then a Wallace J. Gleekman...... 1989 segregated university for "colored" students as they were James U. Piper ...... 1990 then called. Because of his excellent record, he was Valerie Wilcox...... 1991 accepted at M.I.T., studying organic chemistry. He Ernest I. Becker...... 1992 obtained the Ph.D. in 1942 working under Professor Robert Arlene W. Light...... 1993 C. Hockett with the highest grades of the graduate students Truman S. Light...... 1993 in his class. While at M.I.T., he became acquainted with William O. Foye ...... 1994 Professor James Flack Norris of whom he said: Michael E. Strem...... 1995 Alfred Viola...... 1996 He was the first big man I met who was more interested in my ability to Mary T. Burgess...... 1997 learn chemistry than in the identity of my grandparents. Michaeline F. Chen ...... 1997

David M. Howell ...... 1997 Not being able to obtain a position in industry because of John L. Neumeyer...... 1998 prevailing discrimination, he and a few colleagues Morton Z. Hoffman...... 1999 established a small consulting business. In 1946 he joined Catherine E. Costello ...... 2000 Dewey & Almy Co. as Research Supervisor, and in 1952 he Myron S. Simon ...... 2001 became Vice President of National Polychemicals which Michael J. Hearn...... 2002 was active in polymer chemistry. He obtained patents for Doris I. Lewis ...... 2003 blowing agents. Donald O. Rickter ...... 2004 Charles E. Kolb...... 2005 In 1961 he established his own research and consulting Dorothy J. Phillips...... 2006 business, Riverside Laboratories, to be able to pursue his research interests and to allow him to participate in ACS activities.

After his untimely death in 1979, friends and colleagues in the Northeastern Section established the Henry A. Hill Award for Outstanding Service to the Northeastern Section. The first award was made posthumously to Henry A. Hill in 1980; his son, Anthony C. Hill, then a reporter for WGBH, accepted the award. Since then, thirty members of this Section have been thus honored and thereby honored the memory of Henry A. Hill. From an appreciation of Henry A. Hill delivered by Arno Heyn at the1991 Hill Award meeting and based on notes of the late Larry Powell.

76 Honored Members

AMERICAN CHEMICAL SOCIETY

Members - Fifty Years

Robert J. Allen Joseph A. Baglio Frank D. Brako Sam S. Brody Ralph D. Cole L. W. Duncan Jerzy Engel Louis L. Gershman William B. Glen Leon E. Granahan William J. Holloway Albert W. Horlbeck James F. Hornig George L. Innes Martin Isaks Lee A. Johnson Ihor Kocur Edward W. Merrill Richard A. Meyer G. J. O’Neil Joseph S. Panto Alfred Prock Charles P. Riley, Jr. James F. Riordan John L. Roebber Ronald H. Rogstad Alexander D. Shaw Louis Shuster Augustine Silveira Per Sten Stensby Donald L. Towns David L. Williams

77 Invitation to 50-Year Members

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

September 5, 2007

Name Street City, State ZIP

Salutation

Congratulations on your fifty years of membership in the American Chemical Society. I would like to take this opportunity to commend you on your longevity and continued association with chemistry. This is a very important milestone and we of the Northeastern Section would like to celebrate with you.

At the October meeting of the Northeastern Section, in addition to presenting the Hill Award, we will be honoring our fifty-year members. I hope that you (and a guest) will be able to attend as guests of the Section so that we can congratulate you personally. We are also interested in learning about your career in chemistry. If you would like to do so, we would appreciate receiving a brief biographical sketch that can be added to the archives of the Northeastern Section. It can be sent to the Section office at the address or e-mail shown in the letterhead.

You should already have received a 50-year member lapel pin and a 50-year membership card that entitles you to free registration at ACS National and regional meetings. These were sent to you earlier this year directly from the national office of the American Chemical Society.

The meeting is on Thursday evening, October 18, in the University Dining Club on the second floor of the Campus Center at the University of Massachusetts Boston. Additional information and further details of the program for the evening are provided on the enclosed flyer and will also appear in the October issue of The Nucleus. Please contact Marilou Cashman in the Section office by October 11 to make your dinner reservations. She may be reached by phone at (800) 872-2054 or by e-mail at [email protected].

Again, my congratulations and thanks for your many years of service.

Sincerely,

Mukund S. Chorghade, Chair Northeastern Section, ACS

Enclosure

78

October Meeting

The 881st Meeting Northeastern Section of the American Chemical Society Northeastern Section of the American Chemical Society

Progression of a drug from test tube to clinic: A personal adventure

Dr. Mukund S. Chorghade President, Chorghade Enterprises / THINQ Pharma

Dr. W. Harry Mandevill e Thursday – October 18, 2007 University of Massachusetts Boston nd University Dining Club - 2 Floor - Campus Center

5:30 pm Social Hour 6:15 pm Dinner

7:15 pm Evening Meeting – Dr. Mukund Chorghade, NESACS Chair presiding

 Presentation of Certificates to 50-Year Members of ACS  Henry A. Hill Award for Outstanding Service to the Northeastern Section presented to Dr. Ruth Tanner

 Speaker: Dr. Mukund S. Chorghade

Dinner reservations should be made no later than 12:00 noon on Thursday, October 11, 2007. Please contact Marilou Cashman at (800) 872-2054 or (508) 653-6329 or [email protected]. Reservations not canceled at least 24 hours in advance must be paid. Members, $28.00; Non-members, $30.00; Retirees, $15.00; Students, $10.00. Anyone who needs handicapped services, please call a few days in advance so that suitable arrangements can be made.

THE PUBLIC IS INVITED

79

(l-r) Adelaide Cromwell (widow of Henry Hill), Anthony Cromwell Hill (son of Henry Hill), Dr. Ruth Tanner (2007 Henry A. Hill Award Recipient) and 50-year member Martin Isaks (University of Massachusetts Lowell). Taken at the October NESACS Monthly Meeting. Photo by Morton Z. Hoffman.

AWARDS PRESENTED BY THE NORTHEASTERN SECTION, ACS

James Flack Norris Award Ben L. Feringa University of Groningen, the Netherlands in Physical Organic Chemistry (presented at ACS National Meeting)

Gustavus John Esselen Award Prof. Michael A. Marletta University of California Berkeley for Chemistry in the Public Interest

James Flack Norris Award Dr. Diane M. Bunce Catholic University of America for Outstanding Achievement in the Teaching of Chemistry

80

Henry A. Hill Award Dr. Ruth Tanner University of Massachusetts Lowell for Outstanding Service to the Northeastern Section, ACS

Arno H. A. Heyn Memorial Book Award Myron S. Simon Archivist, NESACS

Theodore William Richards Award James Fabiano Newmarket, NH, Jr-Sr H.S. for Excellence in Teaching

Induction into the Aula Laudis Society Gina Bergskaug Hollis-Brookline H.S., Hollis, NH Kevin Cardozo Phillips Academy, Andover, MA James Biller Bishop Brady H.S., Concord, NH Special Recognition / Honorary Judith Kelley University of Massachusetts Lowell / retired

Lyman C. Newell Grant Solomon Berman Chelsea High School to secondary teacher to attend the NEACT Summer Conference

Philip L. Levins Memorial Prize Yuejuan Lin University of Massachusetts Dartmouth

Norris-Richards Undergraduate Summer Ryan Patrick Heney Boston College Research Scholarships Jiajia Cui Dartmouth College Stephen Fried Mass. Institute of Technology Margaret W. Thompson Wellesley College

Undergraduate Grants-in-Aid Certificates Richard K. Hughes, Jr. Boston College Taryn Palluccio Bridgewater State College Chaoyuan Kuang Mass. Institute of Technology Paresh Agarwal Mass. Institute of Technology Todd Andrade University of Massachusetts Dartmouth

Dr. Phyllis A. Brauner Paresh Agarwal Mass. Institute of Technology Memorial Book Award

Project SEED Certificates wth Stonehill College Mentors Sabianca Delva Randolph High School Dr. Cheryl Schnitzer Diane Deng Randolph High School Dr. Louis Liotta Nurbaity Faris Randolph High School

Ashdown Examination Awards: First Place / Simmons College Prize Dianne J. Xiao Acton-Boxborough H.S. Second Place (tie) Matthew J. Curtis Acton-Boxborough H.S. Second Place (tie) Alvin Kerber Sharon High School Fourth Place Sway Chen Lexington High School Fifth Place (tie) :Logan W. Clark Acton-Boxborough H.S. Fifth Place (tie) Charles J. Lee Acton-Boxborough H.S. Fifth Place (tie) Stephen Xu Lexington High School

Honorable Mention - 1st-year Students Ethan Cecchhetti Lexington High School Anji Tang Belmont High School Adhvait M. Shah Burlington High School Kwon-Yong Jin Phillips Academy (Andover) John Kye Cambridge Rindge & Latin H.S. 81

Honorable Mention - 2nd-year Students Jake X. Wang Wayland High School Brittany Fay Concord-Carlisle H.S. Daphne Y. Xiao Acton-Boxborough H.S. Jennifer Schloss Concord-Carlisle H.S. Kenneth Schumacher Andover High School James R. Foster Phillips Academy (Andover)

NCW Prizes Grades K-2 Poster Contest – 1st Place Adam Canfield Joint Entry from Young Scientists Club Jordyn Cooper Littleton, MA Grades 9-12 Poster Contest – 1st Place Marina Kem Malden High School

REPORT OF THE PHYLLIS A. BRAUNER MEMORIAL LECTURE COMMITTEE - 2007 Doris I. Lewis, Chair

Members of the Phyllis A. Brauner Memorial Lecture Committee in 2007 were: Inka Allen Chris Jaworek-Lopez Ruth Tanner Steven Allen Dudley Hershbach Ann Jenkins Bassam Shakhashiri Catherine Brauner Doris I. Lewis Carolyn Spodick Susan Brauner Esther A. H. Hopkins Julianna Lovell

As agreed by the Northeastern Section and the ACS, the Phyllis A. Brauner Lecture is held in the Northeastern Section’s territory in conjunction with National Chemistry Week and named in memory of Dr. Brauner. As envisioned and established by Phyllis, and presented by the Northeastern Section since 1986, the Lecture will be for the general public of all ages. The endowment goal is a $140,000 endowment fund with income supporting the lectures.

Subcommittees met throughout the year to organize experiment preps, to organize volunteer activities, and to coordinate activities with the Museum of Science. Activities of the Committee this year were centered around organizing the 2007 Phyllis A. Brauner Lecture with the NCW theme The Many Faces of Chemistry. This year once more the lecturer was Bassam Shakhashiri, presenting chemical demonstrations; the popular lecture was presented to capacity audiences in the morning and afternoon totaling over 500.In honor of this year being the 50th anniversary of his coming to the United States, in Boston, Bassam Shakhashiri was presented with a Salutes to Excellence Award preceding the morning lecture. This year the Museum of Science offered to host The Brauner Lecture and associated activities, an especially appropriate site since Phyllis Brauner was active in promoting joint activities with NESACS and the Museum of Science. The Northeastern Section web site www.nesacs.org features the National Chemistry Week activities. Activities for the day were led by over forty undergraduate volunteers from local colleges along with other Northeastern Section , and are described in the National Chemistry Week report by Chair Chris Jaworek-Lopez.. Dave Sittenfield of the Museum prepared the reagents and technical arrangements for the Lecture, assisted by Steve and Inka Allen on the day of the lecture. Doris Lewis, and Joe Ciuryla of Suffolk University also assisted in the Lecture activities. Steve Allen annually distributes, collects, and analyzes the evaluation sheets that participants return in exchange for an NCW nanomole favor.

This year a long-time objective of the Brauner Lecture Committee was realized. With the aid of a grant from Merck and an ACS Innovative Projects Grant, we were able to expand the Lecture to a Monday presentation in addition to the Sunday lectures. We had observed that whether the venue was at Wellesley or in the city at the Museum of Science, the audience was mainly composed of relatively affluent families 82 from the suburb, and the Lecture was not reaching inner-city student populations. The partnership with the Museum made this possible, as they were able to use their outreach to city schools to bring school groups to Dr. Shakhashiri’s lecture and to help recruit scientists for the Many Faces of Chemistry activities. Dr. Shakhashiri generously and enthusiastically agreed to the additional morning’s lecture, and participated as well in a new activity designed for the year’s NCW theme The Many Faces of Chemistry in which over two hundred high school students participated in a daylong program. After Dr. Shakhashiri’s lecture the students were able to meet scientists from a variety of fields that use chemistry, including environmental chemists, art preservationists, materials scientists, forensic scientists, and green chemists. Each participating student received a National Chemistry Week gift bag, and each participating teacher received a book on careers in chemistry and a mug.

This year for the first time NESACS NCW was advertised on television. Doris Lewis, chair of the Brauner Committee, was featured on a news broadcast on NewTV (Newton ) describing the Brauner Lecture and other NCW activities, and NewTV aired the NCW promotional video numerous times. Shakashiri’s Once Upon a Christms Cheery in the Lab of Shakhashiri was aired several times during National Chemistry Week, and was so well-received that it continues to be aired regularly. Dr. Lewis and her Suffolk University students in emulation of the Shakhashiri lectures produced a chemical demonstration show that has been aired regularly on NewTV. Additionally, Susan Brauner arranged radio advertising on WBUR in conjunction with the NPR Science Friday show.. With the aid of Cathy Brauner the Brauner Lectures were also featured in the Wellesley Townsman.

The proposed bylaw amendments to the NESACS constitution incorporating the Brauner Committee into the constitution and submitted in November 2006 have yet to be reviewed by the national ACS C & B Committee.

On 12/31/07 the Brauner Memorial Lecture account contained cash and investments totaling $27,617.97. The Brauner share of the Consolidated Account was $42,365.09, so the total value is in excess of $70,000.

During the year, $2000 was transferred to the Section operating account to reimburse 2006 expenses. On 12/31 there was $8957.87 in cash in the account, of which $3713.78 was principal and the remainder was income. The account currently owes the Section operating account $2000 for the 2007 honorarium.

REPORT OF THE COMMITTEE ON AMENDMENTS TO THE CONSTITUTION AND BYLAWS - 2007 Catherine E. Costello, Chair

The committee was composed of the following members:

Catherine Costello, Chair Esther Hopkins Doris Lewis Truman Light Myron Simon Michael Singer

The Board of Directors of the Northeastern Section is presently considering the modification of the Constitution and Bylaws of the Section to introduce an award in honor of Phyllis Brauner, a former Section 83 chair who contributed significantly to the success of the Section over many years. In 2006, discussions were initiated with the National C+B regarding these changes. Doris Lewis, chair of the Brauner Award Committee, provided impetus for these actions and was assisted by Esther Hopkins. No report from the national C+B has been received to date. A C&B modification that would increase the number of members of the Publications committee is under consideration by the C&B committee. No other changes initiated by the Section are under discussion at the present time. Changes recommended at the national level to allow for electronic balloting will be implemented when the pending changes are made.

C&B member Truman Light retired from active service in the section in 2007.

Catherine E. Costello Chair, NESACS C&B Committee

Contact person: Prof. Catherine E. Costello Mass Spectrometry Resource Boston University School of Medicine phone: 617-638-6490 670 Albany Street, Rm 511 fax: 617-638-6491 Boston, MA 02118-2646 e-mail: [email protected]

NORTHEASTERN SECTION - COMMITTEE ON CONTINUING EDUCATION Alfred Viola, Chair

Because of a plethora of ACS Short Courses sent to the Boston area by National during the year 2007 the committee was not active for the 2007 season. Early in the Spring of 2007 National ACS sent several courses on a trial basis to see how such an offering would fare. Only National knows the outcome of this experiment. Subsequently, at the Fall National Meeting held in Boston in August, National ACS presented virtually its entire slate of Short Courses.

The committee expects to resume its activity in 2008.

EDUCATION COMMITTEE Submitted by Ruth Tanner, Chair 2007 Report

Education Committee Members

Ruth Tanner, Chair Undergraduate Programs Stephen Lantos High School Subcommittee Chair Morton Hoffman Professor Emeritus of Chemistry, Boston University. Robert Lichter ACS Scholars

The Education Committee supports and promotes academic program activities that showcase chemical education and young chemists at both the high school and college/university levels. Through announcements at the monthly meetings of the Section, in The Nucleus, and via mailings, information is 84 provided to the membership in order to foster a greater interest in chemical education and to develop a responsible professional outlook toward chemistry among young scientists.

The Chair of the Education Committee, Ruth Tanner, is a chemistry faculty member at the University of Massachusetts Lowell. The Chair of the High School Subcommittee, Stephen Lantos, is a chemistry faculty member at Brookline (MA) High School. The ACS Scholars program is coordinated by Robert Lichter, Principal, Merrimack Consultants, LLC.

James Flack Norris/Theodore William Richards Undergraduate Summer Research Scholarships. (Edwin Jahngen, University of Massachusetts Lowell, Chair).

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards by promoting research interactions between undergraduate students and faculty. Research awards of $3250 were given for the summer of 2007. The student stipend is $2750 for a minimum commitment of ten weeks of full-time research work. The remaining $500 of the award goes to the research advisor to use on supplies, travel, and other items relevant to the student project.

The 2007 scholarships were awarded to:

• Margaret Thompson, Wellesley College; Synthesis of Azide-Labeled reverse Agonists of the Glucagon-Like Peptide 1 Receptor; David Haines, Advisor • Ryan Heney, Boston College; Proposed Synthesis of New Inhibitors of Fructose 1,6- biphosphatase; Evan Kantrowitz, Advisor • Stephen Fried, Massachusetts Institute of Technology; Cofacial Catalysis for Oxygen-Oxygen Bond Formation; Daniel Nocera, Advisor • Jiajia Cui, Dartmouth College; Nickel Binding Properties of the Histidine-Rich Carboxyl Tail Region UreE Protein; John Winn, Advisor

Award winners were required to submit a report of their summer projects by November 2007 for publication in The Nucleus. They are also required to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2008.

85 The scholarships were publicized through The Nucleus, the NESACS Web site, and mailings of applications and descriptive material to the chairs of the Departments of Chemistry, Biochemistry, and Chemical Engineering at colleges and universities in the Section. Applications included student transcripts, descriptions of the proposed research, and two letters of recommendation. The awards enabled the students to spend the summer of 2007 engaged in research at their home institutions.

The Annual Northeast Regional Undergraduate Day The annual Northeast Regional Undergraduate Day sponsored by the Education Committee was not held this year.

The Fourth Undergraduate Environmental Research Symposium. Sponsored by the Education Committee of the Northeastern Section ACS et al., and Coordinated by Edward Brush et al from Bridgewater (MA) State College (BSC).

The Education Committee of NESACS co-sponsored the Sixth Annual Undergraduate Environmental Research Symposium held on Saturday, November 10, 2007 at Bridgewater State College. The symposium focuses on undergraduate and graduate research projects, with a special emphasis on environmental issues of particular concern to Southeaster Massachusetts.

The Symposium ran from 9:00 AM to 2:30 PM and featured 42 poster presentations from undergraduate researchers representing 13 colleges and universities from the New England region. Over 100 students, faculty and mentors were in attendance. The Symposium was officially opened by Matt Moreau, senior biology major at Bridgewater State College. The welcoming remarks were given by BSC President, Dr. Dana Mohler-Faria. President Mohler-Faria spoke of the critical importance that undergraduate research plays in training students to understand and solve the growing problems in our society related to sustainability, global warming and climate change. The formal program began at 9:30 AM with a panel discussion moderated by BSC students Todd Miller (senior physics major) and Theresa Peterson (senior biology/chemistry major). The panel discussion focused on the topic: “The Environmental Impact of Global Warming and Climate Change,” and featured: • Senator Marc Pacheco, Chair of the Senate Committee on Global Warming and Climate Change • Dr. Robert Bertin, Biology Department, College of the Holy Cross: "Ecological Effects of Climate Change" • Dr. Rob Hellstrom, Geography Department, BSC, "Processes of Climate Change in New England: Past, Present and Future" • Dr. Deniz Leuenberger, Political Science Department, BSC, "Heating Up: The Rising Politics of Climate Change in the United States and European Union”

The poster sessions began immediately following the panel discussion, running from 11:00 – 2:30. The complete program with all presenters, titles and abstracts can be accessed from the symposium web page: http://www.bridgew.edu/Environmental/ Attendees completed an evaluation form to help the organizers improve the current format, and plan for new and expanded initiatives. Funding by NESACS was acknowledged. In addition to NESACS, financial assistance was provided by the Bridgewater State College Adrian Tinsley Program for Undergraduate Research and by the NCUR/Lancy Initiative, a program that provides resources to undergraduates who show promise of exceptional achievement. The 7th Annual Environmental Research Symposium is tentatively scheduled for Saturday, November 15, 2008

86 The Northeast Student Chemistry Research Conference (IX). Sponsored by the Education Committee of the Northeastern Section ACS and the Younger Chemists Committee of the Northeastern Section

Held at the Massachusetts Institute of Technology on April 21, 2007, the eighth annual Research Conference brought together undergraduates, graduates students and postdoctoral fellows from the northeastern region of the country for the purpose of celebrating their accomplishments in research, and for providing a forum for the sharing of ideas and scientific understanding. The keynote address, Drugging the Undruggable was given by Professor Gregory Verdine of Harvard University.

Thirty-one poster presentations are given by undergraduate students, graduate students, and post-doctoral fellows. In addition to the research poster presentations, there were 8 student presentations: 4 undergraduate student speakers and 4 graduate student speakers. The presenting students and their institutions were: David Surry (MIT) Selective Palladium-Catalyzed Arylation of Ammonia Richard Hughes (Boston College) Towards the Chemical Synthesis of an Arm-Chair Carbon Nanotube Paresh Agarwal (MIT) An Isolable and Monomeric Phosphorus Radical that is Stabilized by the Vanadium (IV/V) Redox Couple Ashleigh Baber (Tufts University) Scanning Tunneling Microscopy Study of the Dramatic Surface Activity of Au{111} at Low Temperatures due to the Effect of Styrene Adsorption Kathryn O’Brien (Suffolk University) Reduction Chemistry Involving Polymethyldydrosiloxane (PMHS) Anastassia Alexandrova (Yale University) Artificial Enzymes: In Silico Design and QM/MM Characterization Jason Lowe (Boston University) Total Synthesis of the Marine Metabolite Bistramide A Olena Rabotyagova (Tufts University) Spider Silk-Like Block Copolymers

Following the presentations, awards were given for the outstanding speaker and outstanding poster presentations. In addition, a presentation of the NESACS Phyllis Brauner* Undergraduate Book Award was made to Paresh Agarwal from MIT for his excellent oral presentation of his research paper given above. *Dr. Phyllis Brauner received a PhD in Analytical Chemistry from Boston University and was a Distinguished Alumnae. She was a Faculty member at Simmons College for 34 years while at the same time making significant contributions to NESACS thru the many committees she served on, including serving as the Chair of the Board of Directors. She had a fascination with nature and had a passion to pass on that fascination thru chemistry to young people. She inspired her students to love chemistry and to recognize their special role as chemists in society.

87

Grants -in -Aid to Undergraduates (Subcommittee: Ruth Tanner, Martin Isaks)

The Education Committee awarded Grants-in-Aid of $350 each to undergraduates at colleges and universities within the Northeastern Section to enable them to attend the 235th ACS National Meeting in New Orleans, Louisiana to present a paper at the Undergraduate Research Poster Session in the Division of Chemical Education on Monday, April 7, 2008. Matching funds have been committed by the awardees’ institutions to support the students’ travel. The recipients are also required to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2008.

The awardees, their research supervisors, and the titles of their papers are as follows:

• Kevin Robbins, Keene State College (Research Advisor, Colin Abernethy), New Soft Scorpionate Complexes of Vanadium • Jeffrey Garber, Dartmouth College (NH) (Research Advisor, Robert Grubbs) Amphiphilic Block Copolymer Precursors to Cobalt Polymer Hybrids • Jonathan Doran, University of Massachusetts Dartmouth (Research Advisor, Donald Boerth) Nucleophilic Displacement Reactions

Applications for the travel stipend are accepted from students majoring in chemistry, biochemistry, chemical engineering, or molecular biology who are in good standing with at least junior status, and are currently engaged in undergraduate research.

CONNECTIONS TO CHEMISTRY (Ruth Tanner, Chair)

Program Conference Committee: Ruth Tanner, Chair, Education Committee, NESACS; University of Massachusetts Lowell Morton Hoffman, Professor Emeritus, Boston University; 2005 Chair of CHED Steve Lantos, Chemistry Faculty, Brookline (MA) High School

Planning and Program Associates: Christine Jaworek, Chair, National Chemistry Week, NESACS; Emmanuel College 88 Peter Nassiff, Past-Chair, NEACT; Head, Science Division, Burlington High School Arthur Fallon, Head, Media Services, Burlington High School Mark Malagodi, Computer Services, Burlington High School Karen Damasco. Coordinator of Food Services, Burlington High School Nancy Spicer, Biochemist, Sepracor, Inc. Martin Isaks, Chemistry Faculty, University of Massachusetts Lowell James Hall, Director of Freshman Laboratories, University of Massachusetts Lowell Marilou Cashman, Executive Secretary for NESACS.

Material Assistance John Moore, Editor, Journal of Chemical Education Linda Fanis, Assistant Editor, Journal of Chemical Education Terri Taylor, Manager, Office of High School Science, ACS, (ChemMatters) Jamie Warren, ChemMatters, ACS Marilou Cashman, Executive Secretary, NESACS Marvin Wills, Senior Office Administrator, Chemical & Engineering News The Connections program received substantial material assistance from the ACS, and the editorial staff of the Journal of Chemical Education.

Publicity Support New England Association of Chemistry Teachers (NEACT) Massachusetts Association of Science Teachers (MAST) University of Massachusetts Lowell The Nucleus (NESACS)

On October 17, 2007 NESACS sponsored Connections to Chemistry, a unique program to connect high school chemistry teachers to the educational resources of the ACS and to the members of the Northeastern Section. This is the seventh year for the program. Hosted by Burlington (MA) High School, the program drew over 110 teachers from 66 different high schools in Massachusetts, New Hampshire, Connecticut, Rhode Island, and Maine.

The high school chemistry teachers were welcomed to the program by Ruth Tanner (University of Massachusetts Lowell), Chair of the NESACS Education Committee and Chair of the Connections to Chemistry program and by Mukund Chorghade, Chair of NESACS. Terri Taylor from the ACS Office of High School Chemistry, Education Division, was at the opening session to welcome the participants to the program, to encourage them to utilize the ACS CHED resources, to consider affiliate membership in the Division of Chemical Education via the new Chemistry Teacher Connection (CTC) program, and of course, to become active in starting a high school chemistry club affiliated with the ACS. In addition to the welcome, Terri Taylor also presented one of the workshops (noted below) for the program.

Following the opening, five simultaneous workshops were offered in two sessions to showcase the ACS Resources for high school chemistry teachers and students. The Chemistry of Discrepant Events, Steve Lantos, Brookline High School; Chair. High School Education Committee, NESACS Fuels from Renewable Sources John Duffy, Mechanical Engineer, University of Massachusetts Lowell The Chemistry is Right, NCW, Mukund Chorghade, Chorghade Enterprise/THINQ Pharma Chemistry Beyond the Classroom, Terri Taylor, Office of High School Chemistry, ACS Team Science, David Cunningham, Webmaster for NESACS (a two-session workshop) 89 The evening program included dinner and a keynote address Drug Design: From Benchtop to Bedside by Dr, Lori Krim Gavin, Research Scientist, Chemical and Screening Sciences, Wyeth Research. Following her address, several items were raffled, including American Chemical Society items (mugs and laser pen pointers), subscriptions to the Journal of Chemical Education (2 of which, were donated by the Journal) memberships in CHED (donated by CHED), and memberships in CTC (Chemistry Teacher Connection). To conclude the program, participants were given a certificate awarding professional development credits, a year’s subscription to ChemMatters, and a year’s associate membership in the Northeastern Section of the ACS.

David Cunningham, Webmaster, NESACS Workshop Leader for Team Science

Mukund Chorghade, Chorghade Enterprise/THINQ Pharma Workshop Leader, The Chemistry is Right, NCW

90 Terri Taylor, Office of High School Chemistry, ACS Workshop Leader - Chemistry Beyond the Classroom

Ruth Tanner, Chair - Education Committee Lori Gavrin, Wyeth Research - Keynote Speaker Steve Lantos, Chair - H.S. Education Committee

Registration Grants For High School Chemistry Teachers

The Northeastern Section of the American Chemical Society (NESACS) via the Education Committee offered grants for registration reimbursement for the August, 2007 national meeting of the ACS in Boston, MA. High School Chemistry Teachers who lived or worked within the region represented by NESACS (i.e., New Hampshire and eastern Massachusetts) were eligible. The reimbursement was for the $78.00 registration fee; transportation, lodging, and food was not reimbursed. Registration for the meeting entitled them to access to all workshops, any session in any division, all presentations, exhibitions, and non-ticketed events throughout the meeting. Thirteen (13) grants were awarded to area high school chemistry teachers.

ACS SCHOLARS PROGRAM (Robert Lichter, Chair)

ACS Scholars: 2007 calendar year.

This is the seventh year for the involvement of the NESACS in the ACS Scholars Program. The NESACS sponsored one student, Jose Barcena, a chemical engineering major at MIT.

In the 2007 calendar year, 32 Scholars are studying within NESACS: First Last College Major Tasha L. Drake Amherst College Chemistry 91

Hector J. Lefbad Franklin W. Olin College of Engineering Chemical Engineering

Beatriz A. Brando Harvard University Chemistry Chikezie I. Eseonu Harvard University Biochemistry & Biomed. Eng. Shirley Lemus Hufstedler Harvard University Biochemistry Melissa Q. McCreery Harvard University Chemistry & Physics Jennifer N. Obiaya Harvard University Chemistry & Environmental Sci. Geneva M. Trotter Harvard University Materials Engineering James J. Watts Harvard University Biochemistry

Silvana R. Arevalo Massachusetts Institute of Technology Chemical Engineering Jose R. Barcena Massachusetts Institute of Technology Chemical Engineering Nia S. Beckley Massachusetts Institute of Technology Chemical & Biological Eng. Richard V. Burgess, II Massachusetts Institute of Technology Chemical Engineering Yamicia D. Connor Massachusetts Institute of Technology Chemical Engineering & Biology Hanzel D. Corella Massachusetts Institute of Technology Chemical Engineering Jamira V. Cotton Massachusetts Institute of Technology Chemical Engineering Fanny Frausto Massachusetts Institute of Technology Chemistry Ismael J. Gomez Massachusetts Institute of Technology Chemical Engineering Doris M. Grillo Gonzalez Massachusetts Institute of Technology Chemical Engineering Robert D. Jackson Massachusetts Institute of Technology Chemical-Biological Eng. Phillip N. Laker-Ojok Massachusetts Institute of Technology Chemical Engineering Lunet E. Luna Massachusetts Institute of Technology Chemical Engineering Kristen T. Martinez Massachusetts Institute of Technology Chemical Engineering Nicholas A. Pearce Massachusetts Institute of Technology Chemical Engineering Willie M. Reese Massachusetts Institute of Technology Materials Science & Engineer. Star A. Simpson Massachusetts Institute of Technology Materials Science Jillian A. Smith Massachusetts Institute of Technology Chemical Engineering Aline Thomas Massachusetts Institute of Technology Chemical Engineering Gabriel A. Tobon Massachusetts Institute of Technology Chemical Engineering Roberto Velazquez Massachusetts Institute of Technology Chemistry

Mark V. Michelman Northeastern University Chemical Engineering

Camille I. Petersen Tufts University Chemistry & Biochemistry

In continuing efforts to build connections with the ACS Scholars in the NESACS area, the Section invited the 32 current Scholars to a lunch on 8 February 2007 in the Department of Chemical Engineering at MIT, where the largest single number of Scholars is enrolled. Also invited were their mentors, representatives of SA chapters, YCC officers, one Scholar alumna, and a few others. The centerpiece of the lunch was the opportunity to meet and speak with that evening's meeting speaker, Ms. Jeannette Brown. The larger purpose was to allow the Scholars to meet each other, and to encourage them to think about ways for the Section to help them achieve their academic and career goals.

Ultimately, because of classroom conflicts--some at the last minute--only a small number of Scholars were able to attend. Those present were Scholars Fanny Frausto (MIT) and Beatriz Brando (Harvard); alumna Shanadeen Begay (BU); NESACS YCC Chair Laila Dafik; and YCC member Deniz Yuksel. Ms.

92 Dafik and Ms. Wuksel are graduate students at Tufts University. The other three Scholars who had planned to attend did send emails stating that unexpected class conflicts had arisen. NESACS members included Mukund Chorghade, Mort Hoffman, Robert Lichter, Dorothy Phillips, and the evening speaker, Jeannette Brown. A lively discussion ensued, in which both the YCC and the Scholars were encouraged to think about programming for meetings or about other activities that would appeal to their constituencies. The Scholars who were present are going to keep in touch with each other to develop ideas for strengthening linkages among their cohort. Ms. Frausto is interested in starting a SA chapter at MIT. I will stay in touch with them.

Several Scholars were at the evening presentation: Beatriz Brando (Harvard, Chemistry), Shirley Lemus Hufstedler (Harvard, Biochemistry), Geneva Trotter (Harvard, Materials Engineering), and James Watts (Harvard, Molecular and Cellular Biology), as well as alumna Shanadeen Begay. Brando and Watts are freshmen, Trotter a sophomore, and Lemus Hufstedler a senior. None of them had known each other, even though Brando and Watts discovered they were taking the same course.

The turnout, although small, is encouraging nonetheless, because we've at least identified a few from whom we can start to build some connections. These students are all highly articulate and engaged. They represent a long-term resource that can strengthen the Section.

All of these Scholars are contacted by e-mail monthly from September to May, and informed of NESACS activities of interest to undergraduates. In particular, they were invited to attend the monthly meetings of the Section, and to be its guests at the social hours and dinners that preceded the invited speakers. They also were put on the mailing list to receive THE NUCLEUS.

YCC/NESACS–JCF/GDCh German Exchange (Michael Strem, Strem Chemicals, Chair, Ruth Tanner, Morton Hoffman, and YCC Members.

The Younger Chemists Committee (YCC) of the Northeastern Section and the NESACS Education Committee co-sponsored an exchange of students from Germany August 18-25, 2007. This was a continuation of the German Exchange program of the NESACS.

The German delegation attended the national ACS meeting in Boston, MA. They displayed research posters in the relevant technical divisions and at Sci-Mix (Monday, 8-10 p.m.), and participated in a reception in their honor (Sunday 5:30-7 p.m.). At the reception, the research posters of the German students and posters from JCF, YCC, and other sponsors were on display, which provided an opportunity for attendees to speak to the presenters in the informal setting. In addition, tables for the display of materials by the sponsors of the reception were available. Some short welcoming remarks were made, and Salutes to Excellence awards were presented

A symposium with CHED as the sponsoring technical division was organized by Hoffman, and was cosponsored by the German Chemical Society, ACS International Activities Committee, CHED International Activities Committee, ACS Northeastern Section, Graduate Student Symposium Planning Committee, Society Committee on Education, Women’s Chemist Committee, and Younger Chemists Committee. In addition, thanks to an Innovative Projects Grant from the ACS Divisional Activities Committee to CHED, Dr. Marianne Sgoff, a high school teacher of chemistry in Germany, came to Boston for the ACS meeting. She spoke in the CHED High School Program (The High School-College Interface) on Sunday morning at 9:10 a.m. on “Challenges of Teaching High School Chemistry in Germany.” Four of the students presented oral contributions in a symposium in the Division of Chemical Education (CHED), Connections to Germany: Research and Education Opportunities, on Sunday afternoon, 1:30-5 p.m. 93

NESACS organized excursions, laboratory visits, and other events of a scientific and cultural nature.

Plans are underway for the next Exchange in March, 2008 when a delegation of chemistry undergraduate and graduate students from NESACS will travel to Rostock, Germany for the JCF Frühjahrssymposium. We hope that the Exchange will continue with another visit by undergraduates and graduate students from NESACS to Germany in 2009. We look forward to the opportunity to welcome JCF to Boston in August 2010 on the occasion of the next ACS National Meeting in Beantown.

(Most of the information reported above for the Exchange Program appeared in the group’s report to THE NUCLEUS, the NESACS monthly publication, written by Mort Hoffman.)

94 95

EDUCATION COMMITTEE High School Subcommittee Stephen Lantos, Subcommittee Chair

High School Subcommittee Members Stephen Lantos, Chair Peter Nassiff Avery A. Ashdown Examination Ruth Tanner Lyman C. Newell Grants David Olney Aula Laudis Society Stephen Lantos Theodore William Richards Award

Avery A. Ashdown High School Chemistry Examination Contest & U.S. Chemistry Olympiad Team (Ashdown Committee: Peter Nassiff, Chair; Steve Lantos (Olympiad Section Coordinator: Steve Lantos)

The HS Education Committee continues to sponsor and run the annual Avery Ashdown High School Examination Contest. Since the early 1970s, the exam seeks participation from nearly 40 schools across the section with over 100 students sitting annually for the exam each spring. Cash prizes are awarded to the top five scorers; honorable mention certificates are given to the students earning the top five scores at each of the two levels--first and second year. Peter Nassif will continue to head the exam writing and administration of the Ashdown Exam. Top scorers from the exam are eligible to participate in the United States National Chemistry Olympiad. We hope that increased participation and awareness of these competitive chemistry exams will allow NESACS to send one of our students to the 2008 International Chemistry Olympiad, held this summer in Budapest, Hungary.

The Northeastern Section continues to pilot the new ACS High School Chemistry Clubs program, now in its third year. We encourage interested teachers across the section to consider starting an ACS-sponsored Chemistry Club in their school. For details, please contact Steve Lantos. We’re in the midst of advertising and initiating these programs within our section and have received a positive response from the Section’s high school chemistry teachers.

The Education Committee helped to plan and coordinate the successful High School Day Program, held Aug. 19th at the 2007 National ACS Meeting here in Boston. In attendance were some familiar faces from across the section, and many new participating high school educators. We look forward to Boston 2010!

2007 Ashdown Examination Awards: First Place / Simmons College Prize Dianne J. Xiao Acton-Boxborough H.S. Second Place (tie) Matthew J. Curtis Acton-Boxborough H.S. Second Place (tie) Alvin Kerber Sharon High School Fourth Place Sway Chen Lexington High School Fifth Place (tie) Logan W. Clark Acton-Boxborough H.S. Fifth Place (tie) Charles J. Lee Acton-Boxborough H.S. Fifth Place (tie) Stephen Xu Lexington High School

Honorable Mention - 1st-year Students Ethan Cecchhetti Lexington High School Anji Tang Belmont High School 96 Adhvait M. Shah Burlington High School Kwon-Yong Jin Phillips Academy (Andover) John Kye Cambridge Rindge & Latin H.S.

Honorable Mention - 2nd-year Students Jake X. Wang Wayland High School Brittany Fay Concord-Carlisle H.S. Daphne Y. Xiao Acton-Boxborough H.S. Jennifer Schloss Concord-Carlisle H.S. Kenneth Schumacher Andover High School James R. Foster Phillips Academy (Andover)

Lyman C. Newell Grants Ruth Tanner, Chair

The Lyman C. Newell Grants provide financial assistance to high school teachers in the geographical area of the Northeastern Section of the ACS to subsidize the cost of attending the annual summer conference sponsored by NEACT, the New England Association of Chemistry Teachers. The grants are administered by the Newell Grants Committee. The Committee administers the grant process starting with the publicity to the awarding of the grants. The Committee coordinates its activities with the Chair of the Education Committee and the President of NEACT.

The Northeastern Section of the American Chemical Society awarded four Lyman C. Newell Grants for the 68th Annual Summer Conference of the New England Association of Chemistry on Green Chemistry at Bridgewater State College, in Bridgewater, MA, August 7-10, 2006. Grants of $225.00 each to partially cover the cost of the conference have been awarded to the following high school teachers:

Esther Hines at Lexington High School in Lexington, MA Nancy Jean Ward at East Bridgewater High School in East Bridgewater, MA Kimberly Rebello at Bristol Plymouth Technical High School in Taunton, MA Marcia Boccuzzi at Fairfield Ludlowe High School in Trumbull, CT

The four-day conference will give participants opportunities to work in the lab and to design new activities, to view demonstrations and to discuss a broad variety of applications of Green Chemistry in academia and in industry. The program is co-sponsored by NEACT and the Department of Chemical Sciences at Bridgewater State College.

The Lyman C. Newell Grants commemorate a former chair of the Northeastern Section who was a distinguished chemist, teacher, and historian of chemistry. For many years he was chair of the Chemistry Department at Boston University. Lyman Newell served as the first president of NEACT from 1889 to 1900 and expressed a continuing interest in training chemistry students throughout his long career. His efforts are continued by grants that bear his name.

Aula Laudis Society (Committee: Dave Olney, Chair; Kathy Skelly, Helen O’Keefe)

The Section recognizes outstanding secondary school teachers of chemistry by naming them to the Aula Laudis Society at the Annual Education Awards Night conducted in May. In 2007, four area teachers were inducted into the Society; i.e., Gina Bergskaug Hollis-Brookline H.S., Hollis, NH Kevin Cardozo Phillips Academy, Andover, MA James Miller Bishop Brady H.S., Concord, NH 97 Judith Kelley University of Massachusetts Lowell / retired Special Recognition / Honorary

Theodore William Richards Award (Committee: Steve Lantos, Chair, Emily Dudek, Christopher Doona, Martin Idelson) The Theodore William Richards Award for Excellence in Teaching of Secondary School Chemistry was awarded to James Fabiano from Newmarket, NH, Jr-Sr High School..

From the Nucleus

James Fabiano (Newmarket (NH) Junior-Senior High School), recipient of the Theodore William Richards Award for Excellence in Teaching of Secondary School Chemistry; Kristin Kiefaber (Newmarket (NH) Jtounior-Senior High School); Scott Weber (Newmarket (NH) Junior-Senior High School); teve Lantos (Brookline (MA) High School), NESACS High School Education ommittee Chair. (Photo by Morton Z. Hoffman)

98 99 100

SAMPLE FORMS USED IN HIGH SCHOOL AND COLLEGE MAILINGS / WEB POSTINGS

Call for Papers – Grant-in-Aid Program

Call for Papers Undergraduate Research Poster Session

at the

235th National Meeting of the American Chemical Society New Orleans, Louisiana April 6 – 10, 2008 The ACS invites undergraduate students to submit abstracts of their research papers for presentation at the Undergraduate Research Poster Session (URPS), which will be part of the extensive programming for undergraduates at this national meeting. Submit your abstract electronically by October 28, 2007 (11:59 pm EST) to . Click on the CHED division and then select the URPS site that is appropriate to the subject of your paper. Please follow the directions carefully.

For further information, contact: Nancy Bakowski ACS Student Affiliates Program 1155 Sixteenth Street, NW Washington, DC 20036 Tel: (800) 227-5558, ext. 6166 e–mail: [email protected] 101

Grant-in-Aid Letter to Winners NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

October 23, 2007

Line 1 Line 2 Line 3 Line 4 Line 5

Salutation:

On behalf of the Northeastern Section of the American Chemical Society (NESACS), I want to take this opportunity to congratulate you as a recipient of a Grant-in-Aid of $350 to enable you to attend the 235th National Meeting of the American Chemical Society in New Orleans, Louisiana, and to present a paper at the Undergraduate Research Poster Session in the Division of Chemical Education. It will be your responsibility to arrange for your own transportation and housing at the meeting; details about the meeting will be given in Chemical & Engineering News in the course of the next several months.

A check from NESACS will be sent to you at your campus address after the presentation of your poster at the ACS meeting that will take place from April 6-10, 2008. If your address changes before then, please notify me. At least $350 has been committed for your travel by your institution; you should consult with the chairperson of your department about this portion of your travel funds.

As a recipient of this award, you are also required to present your poster at the Northeast Student Chemistry Research Conference (NSCRC) to be held on Saturday, April 19, 2008. You will receive more information about this event in due course. To honor your award further, you and your research advisor will be invited to be guests of the Section at the NESACS Education Night in May.

I congratulate you on your achievement, and look forward to seeing you and your poster in New Orleans. I wish you good luck on your research project, and in your continued study of chemistry.

Sincerely yours, Dr. Ruth Tanner, Chair NESACS Education Committee c: Advisor

102 Call for Applications The James Flack Norris and Theodore William Richards

Undergraduate Summer Research Scholarships

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards by promoting research interactions between undergraduate students and faculty.

Research awards of $3250 will be given for the summer of 2007. The student stipend is $2750 for a minimum commitment of ten weeks of full-time research work. The remaining $500 of the award can be spent on supplies, travel, and other items relevant to the student project.

Institutions whose student/faculty team receives a Norris/Richards Undergraduate Summer Research Scholarship are expected to contribute toward the support of the faculty members and to waive any student fees for summer research. Academic credit may be granted to the students at the discretion of the institutions.

Award winners are required to submit a report (~5-7 double-spaced pages including figures, tables, and bibliography) of their summer projects to the NESACS Education Committee by November 2, 2007 for publication in THE Nucleus. They are also required to participate in the Northeast Student Chemistry Research Conference (NSCRC) in April 2008.

Eligibility: Applications will be accepted from student/faculty teams at colleges and universities within the Northeastern Section. The undergraduate student must be a chemistry, biochemistry, chemical engineering, or molecular biology major in good standing, and have completed at least two full years of college-level chemistry by summer, 2007.

Application: Application forms are available on the NESACS web site at http://www.nesacs.org. Completed applications are to be submitted no later than April 6, 2007 to the Chair of the Selection Committee:

Professor Edwin Jahngen University of Massachusetts Lowell Chemistry Department, Room 520, Olney Hall 1 University Avenue Lowell, MA 01854-5047

Notification: Applicants will be notified of the results by e-mail on April 25, 2007 with written confirmation to follow. 103 Informational Letter – Summer Research Scholarships NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

February 16, 2007

To: Chairpersons of Departments of Chemistry, Chemical Engineering, and Biochemistry (Colleges and Universities in the Northeastern Section of the American Chemical Society)

From: Professor Ruth Tanner (University of Massachusetts Lowell), Chair Education Committee of the Northeastern Section of the American Chemical Society

Subject: Applications for Norris/Richards 2007 Undergraduate Summer Research Scholarships

The Northeastern Section of the American Chemical Society (NESACS) established the James Flack Norris and Theodore William Richards Undergraduate Summer Scholarships to honor the memories of Professors Norris and Richards through the promotion of research interactions between undergraduate students and faculty. Research awards of $3,250 will be given for the Summer of 2007, which include a stipend to the student of $2,750 for a minimum of ten weeks of full-time research work; the remaining $500 can be spent on supplies, travel, and other items related to the student project. I am asking for your help to make sure that all those student/faculty pairs who might be interested in applying for support are informed of this program. The deadline for receipt of the completed applications (with two supporting letters) is April 6, 2007. Applicants will be notified of the results on April 25, 2007. Completed applications must be submitted to the Chair of the Selection Committee: Professor Edwin Jahngen University of Massachusetts Lowell Chemistry Department, Room 520 1 University Avenue, Olney Hall Lowell, MA 01854-5047

Enclosed is an announcement of the program. I ask you to distribute and post it where students and faculty will see it. I would also appreciate your help in making sure that students who might qualify for the scholarships, but who are majors in departments not covered by this mailing, have an opportunity to obtain the information.

Institutions whose student/faculty team receives a Norris/Richards Fellowship are expected to contribute toward the support of the faculty member and to waive any student fees for summer research. Academic credit may be granted to the students at the discretion of the institutions. Award winners are required to submit a report of their summer projects by November 2, 2007, for publication in The Nucleus, and to participate in the NESACS Northeast Student Chemistry Research Conference in April 2008.

Application forms are available on the NESACS web site at http://www.nesacs.org. If you, your students, or your faculty have any questions about the program or the application, call me at (978) 934-3662 (e-mail: [email protected]), or contact Professor Edwin Jahngen, Chair of the Selection Committee at (978) 934-3693 (e-mail: [email protected]).

Thank you for helping to make this program known and for promoting undergraduate research as a vital part of chemical education. 104

NORRIS-RICHARDS NOTIFICATION LETTER NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

April 26, 2007

Line 1 Line 2 Line 3

Salutation:

CONGRATULATIONS!

I am pleased to inform you that you have been selected to receive a 2007 James Flack Norris / Theodore William Richards Summer Research Scholarship. This award carries a stipend of $2750 for a minimum commitment of ten weeks of full-time summer research. Another $500, to be spent at the discretion of your research advisor, is available for faculty support, supplies, travel, and other items relevant to the project.

You will receive one-half of the stipend at the award ceremony on May 10. The second half will be sent to your research advisor around July 1. You are required to submit a report of your summer work to me (Chemistry Department, Olney Hall, 265 Riverside Street, Room 520, University of Massachusetts Lowell, Lowell, MA 01854- 5047) by November 2, 2007 for publication in The Nucleus. This report should be ~5-7 double-spaced typed pages, including figures, tables, and bibliography. Upon my receipt of your report, the $500 for the support of your research will be released to your advisor. In addition, the student is to present his/her work at the Northeast Student Chemistry Research Conference (NSCRC) on Saturday, April 19, 2008. The student will receive reminders of these obligations.

The presentation of the award to you will be made at the 879th meeting of the Northeastern Section on Thursday, May 10, at Northeastern University. A flyer is enclosed providing additional information. You are cordially invited to be the guest of the Northeastern Section for the social hour and dinner starting at 5:15 p.m. The award presentations will be preceded by a talk by Dr. Steve Jones of Sepracor in Marlborough, MA, whose talk is entitled “The Interplay of Chemistry and Biology.” Your research advisor has also been invited to the dinner as a guest of the Northeastern Section.

Should your parents or friends desire to attend, the cost of the dinner is $30.00 ($10.00 for students). Please respond by e-mail, phone or fax to the Section Office by noon on May 3 to confirm your attendance and make any additional reservations. If you prefer a vegetarian meal, please indicate so when making your reservation(s). A message may be left on the tape if no one is in the office when you call.

I extend my congratulations to you and look forward to seeing you on May 10. I wish you a very productive summer of research.

Sincerely yours,

Dr. Ruth Tanner, Chair NESACS Education Committee 105

Call for Nominations – Richards Teaching Award

Northeastern Section AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

THEODORE WILLIAM RICHARDS AWARD FOR EXCELLENCE IN TEACHING SECONDARY SCHOOL CHEMISTRY

ANNOUNCEMENT OF AN AWARD PROGRAM

April 2007

Dear Science Department:

Do you know an excellent Chemistry teacher to nominate for the 2007 Theodore William Richards Award for Excellence in Teaching Secondary School Chemistry sponsored by the Northeastern Section of the American Chemical Society? We feel that there are many outstanding and exceptional Chemistry teachers in the Northeastern Section, so please take the time to nominate one of the deserving faculty members from your school.

The prestigious Theodore William Richards Award for Excellence in Teaching Secondary School Chemistry is presented annually to a teacher who demonstrates exceptional innovation and dedication in inspiring students (majors and non-majors alike), communication in the principles of chemistry in and out of the classroom, and leadership in influencing and mentoring other chemistry teachers. Sound like someone you know or work with? Then use the attached nomination form and recognize that teacher’s talents.

Nominations by STUDENTS (current or former), COLLEAGUES, DEPARTMENT HEADS, or INDIVIDUALS who choose to self-nominate are eligible for consideration. The deserving recipient will be honored at the Education Night ceremony in May and presented with a $1,500 cash prize and Certificate of Recognition.

Thank you for your attention in bringing recognition to the talented Chemistry teachers of the Northeastern Section, and hopefully the next deserving recipient of the prestigious Theodore William Richards Award will be from your school. Please send nomination forms by April 20, 2007 to: Steve Lantos Brookline High School 115 Greenough Street Brookline, MA 02445 e-mail: [email protected]

This information can be found on the website of the Northeastern Section, ACS: http://www.nesacs.org 106

Informational Letter – Ashdown Exam

Northeastern Section AMERICAN CHEMICAL SOCIETY

ADMINISTRATIVE SECRETARY PHONE OR FAX 23 COTTAGE STREET (508) 653-6329 NATICK, MA 01760 MA AND NH ONLY E-MAIL: [email protected] (800) 872-2054

TO: High School Chemistry Teachers FROM: Steve Lantos, Chair, High School Education Committee DATE: February 2007

NOTE: Please refer to the website of the Northeastern Section for Ashdown Examination information and registration forms. The URL is http://www.nesacs.org

This year's Avery Ashdown High School Chemistry Examination Contest of the Northeastern Section of the American Chemical Society will take place on SATURDAY, MARCH 31, 2007, starting at 9:00 a.m. at

SIMMONS COLLEGE 300 The Fenway Boston, MA 02115

At Simmons, we will be using rooms in the Science Building which is directly behind the Main College Building. Free parking will be available in the college parking lot located off Avenue Louis Pasteur. Parking permits will be issued at Simmons.

Each high school in the Northeastern Section may be represented by a maximum of five (5) participants selected by their school or teachers for each exam.. (One alternate may be named on the registration form, but only five students will be tested.) Winners of cash awards in previous years are not eligible to compete for Ashdown recognition; however, they may compete to become eligible for the Olympiad Examination. Cash awards will be given to the students with the top five (5) scores. Honorable mention awards will be given to five (5) first-year and five (5) second-year students with the next highest scores. In addition, each winning student will be invited, along with his/her teacher, to be guests of the Northeastern Section at its May 10, 2007, dinner meeting and will be given appropriate recognition. SCORES WILL BE REPORTED TO TEACHERS VIA E-MAIL IF ADDRESSES ARE PROVIDED ON THE TEACHER REGISTRATION FORM.

Top scorers in the Ashdown Examination will be eligible to take the qualifying exam for the Unites States Chemistry Olympiad Team on April 21. PLEASE SEE THE GUIDELINES ON THE REVERSE SIDE OF THIS MEMO FOR MORE INFORMATION ABOUT THE ASHDOWN EXAMINATION AND THE INTERNATIONAL CHEMISTRY OLYMPIAD.

Please return the enclosed STUDENT and TEACHER REGISTRATION FORMS by Tuesday, March 27, 2007, to register your students for the Ashdown Exam. Each student should bring #2 pencils to the examination. Students may use programmable or graphing calculators provided the memory is erased from the programs. This will be verified by proctors before the exam.

107 Along with the enclosed form for registration of students, it is requested that each school send $5.00 per student ($25 maximum) in order to help defray the cost of prizes and awards. The check should be made out to NESACS - Ashdown Exam. (Please DO NOT SEND PURCHASE ORDERS.)

Please be certain that your students make careful note of the exact information about the examination since this is not an official function of the college involved and few on campus will be aware of essential details. Any questions about the details of the examination should be directed, preferably by e-mail, to: Dr. Peter Nassiff Burlington High School Burlington, MA 01803 781-270-2923 e-mail: [email protected]

Questions relating to registrations for the exam should be directed to: Marilou Cashman (508) 653-6329 or (800) 872-2054 e-mail: [email protected] NOTE: The Northeastern Section office WILL BE CLOSED from MARCH 14 through MARCH 24. E- mails that come in during those dates will be responded to after March 25.

Note: This information, with the Guidelines and Registration Forms, can be found on the internet at http://www.nesacs.org

2007 AVERY A. ASHDOWN EXAMINATION GUIDELINES

1. Entrants. The Ashdown Examination has traditionally divided students into two categories: first- year and second-year/AP level. In the past, problems have arisen in defining those students who are taking chemistry as a second-year course but do not follow the AP curriculum and those who are taking a first-year course but do follow the AP curriculum. The Examination Committee’s goal is to test for chemical knowledge rather than to define the academic guidelines of entrants. Thus, students will be classified as first-year (first exposure to chemistry) and second-year (a second-year of chemistry), regardless of a course name, curriculum, or an individual's background. We feel this will most fairly include as many as possible in taking the examination

2. Scoring and Prizes. Five cash prizes will be given for the top scores of ALL entrants. Duplicate scores in the top five will be considered as two of the five scores. Scoring is determined by raw score. The next five scores for both first and second year will be awarded an Honorable Mention and certificate, regardless of duplicate scores. Recognition will also be given to each teacher.

3. The Exam. The examination will be 100 multiple-choice questions. No penalty will be deducted for wrong answers.

4. U. S. National Chemistry Olympiad (USNCO). Those students wishing to compete in the International Chemistry Olympiad (IChO) qualifying examination will be selected from the top scorers. Should there be a duplicate score, both entrants may be considered. Students must be U. S. Citizens by the date of the USNCO. Only two students from any school may compete.

5. Other. Students may use programmable or graphing calculators provided the memory is erased from the programs. Proctors will verify this. Within one week of the exam date, student scores will be

108 mailed or e-mailed to the participating schools notifying teachers of the winners. A breakdown of the range of scores and high scorers will be included along with a distribution of the types of chemistry questions included on this year's examination.

No cellular telephones will be permitted in the examination room. A secure room will be made available at the test site to store phones and bookbags.

Should there be questions about the examination, please contact Dr. Peter Nassiff at (781) 270-2923 or by e-mail to [email protected]. Questions about registrations for the exam should be addressed to the Administrative Secretary by e-mail to [email protected]

NOTE: The Northeastern Section office WILL BE CLOSED from MARCH 14 through MARCH 24. E- mails that come in during those dates will be responded to after March 25.

Dates

Registration Deadline for Ashdown Examination Tuesday, March 27, 2007 The Ashdown Examination Contest Saturday, March 31 at 9:00 a.m. at Simmons College The Qualifying Olympiad Exam Saturday, April 21 at 9:00 a.m. at Simmons College. The exam will be administered only to the top scorers on the Ashdown Exam. These students will be notified by telephone within a day or two after the Ashdown Exam. NESACS Education Night Awards Dinner Thursday, May 10, 2007 at Northeastern University. (Ashdown Award prizewinners and their teachers will be honored. Note: This information may also be found on the internet at http://www.nesacs.org

109 Sample Education Committee Items from The Nucleus 2007 bibliography) of their summer projects Announcement to the NESACS Education Committee The James Flack Norris by November 2, 2007 for publication and Theodore William Richards in The Nucleus. They are also required Undergraduate Summer Research Scholarships to participate in the Northeast Student The Northeastern Section of the American Chemistry Research Conference Chemical Society (NESACS) (NSCRC) in April 2008. established the James Flack Norris and Eligibility: Applications will be Theodore William Richards Undergraduate accepted from student/faculty teams at Summer Scholarships to colleges and universities within the honor the memories of Professors Norris Northeastern Section. The undergraduate and Richards by promoting research student must be a chemistry, biochemistry, interactions between undergraduate chemical engineering, or students and faculty. molecular biology major in good Research awards of $3250 will be standing, and have completed at least given for the summer of 2007. The two full years of college-level chemistry student stipend is $2750 for a minimum by summer, 2007. commitment of ten weeks of fulltime Application: Application forms are research work. The remaining available on the NESACS web site at $500 of the award can be spent on supplies, http://www.nesacs.org. Completed travel, and other items relevant applications are to be submitted no to the student project. later than April 6, 2007 to the Chair of Institutions whose student/faculty the Selection Committee: team receives a Norris/Richards Professor Edwin Jahngen Undergraduate Summer Research University of Massachusetts Lowell Scholarship are expected to contribute Chemistry Department, toward the support of the faculty members Room 520, Olney Hall and to waive any student fees for 1 University Avenue summer research. Academic credit Lowell, MA 01854-5047 may be granted to the students at the Notification: Applicants will be notified discretion of the institutions. of the results by e-mail on April Award winners are required to 25, 2007 with written confirmation to submit a report (~5-7 double-spaced follow pages including figures, tables, and

REPORT OF THE ESSELEN AWARD COMMITTEE – 2007 Robert Langer, Chair

The 21st Gustavus John Esselen Award for Chemistry in the Public Interest was presented on April 12, 2007 to Dr. Michael A. Marletta, Aldo DeBenedictus Chair in Chemistry and Chair of the Department of Chemistry, University of California, Berkeley. Dr. Marletta was recognized for his contributions to nitric oxide biochemistry. His pioneering work provided the required information for the isolation and characterization of NO synthase, a complex redox protein whose structural features he elucidated, demonstrating that the synthase contained a cytochrome P-450 type heme component.

The award reception and dinner were held at the Harvard Faculty Club with approximately 80 people in attendance. The award ceremony and recipient’s address, “Nitric Oxide in Biology: From Discovery to Therapeutics." were held in the Pfizer Lecture Hall in Mallinckrodt Chemistry Building. The award recipient was introduced by Dr Robert Langer. The award, consisting of a medal and a check for $5000, was presented to Dr. Marletta by Mr. Gustavus John Esselen, IV.

110 The members of the 2007 Award Committee were: Rudi Baum, C&E News; Roy Gordon, Harvard University; William Klemperer, Harvard University, Robert Langer, MIT; Joseph Lima, Houghton Chemical Company; John Neumeyer, McLean Hospital; and Thomas Verhoeven, Eli Lilly, Corp.

?? (Mr. Joseph Lima will succeed Robert Langer as Chair of the Esselen Award Committee for 2008, with duties to commence after the Esselen Award events for 2007.)

Submitted by, Robert Langer, Chair Esselen Award Committee, 2007

Dr. Michael Marletta Esselen Award Recipient 2007

Invitation to Esselen Award Dinner

The Board of Directors of the Northeastern Section of the American Chemical Society requests the honor of your presence on the occasion of the twenty-first presentation of The Gustavus John Esselen Award for Chemistry in the Public Interest to Michael A. Marletta on Thursday, April 12, 2007

5:30 o’clock 8:15 o’clock Preprandial hour and dinner Award ceremonies Harvard Faculty Club Pfizer Lecture Hall 20 Quincy Street Mallinckrodt Chemistry Laboratories Cambridge, Massachusetts 12 Oxford Street Cambridge, Massachusetts Black Tie Optional

111 Esselen Award Dinner Program

Presentation of the

Twenty-first

GUSTAVUS JOHN ESSELEN AWARD

for

CHEMISTRY IN THE PUBLIC INTEREST

to

MICHAEL A. MARLETTA

Thursday, April Twelfth Two Thousand Seven Harvard University Cambridge, Massachusetts

112

MICHAEL A. MARLETTA Aldo DeBenedictus Distinguished Chair in Chemistry and Chair of the Chemistry Department University of California, Berkeley

Michael Marletta received his baccalaureate degree in Chemistry and Biology from SUNY, College at Fredonia in 1973 and his Ph.D. from the University of California, San Francisco in 1978 with Prof. George L. Kenyon. After a postdoctoral fellowship with Christopher Walsh at M.I.T., he joined the faculty at M.I.T. as Assistant Professor of Toxicology. In 1978 he joined the faculty at the University of Michigan as an Associate Professor with joint appointments in the College of Pharmacy and School of Medicine. He moved to the University of California, Berkeley in 2001.

Dr. Marletta is the author of more than 140 research papers and has produced over 25 Ph.D. graduates from his research group. He is one of the few chemists ever elected to the Institute of Medicine of the National Academy of Sciences. Among his recent awards are his election to the National Academy of Sciences, receipt of the Harrison Howe Award of the Rochester ACS Section and receipt of the 2007 Repligen Award of the ACS Division of Biological Chemistry

Dr. Marletta is widely known for his contributions to nitric oxide biochemistry. His pioneering work provided the required information for the isolation and characterization of NO synthase, a complex redox protein whose structural features he elucidated, demonstrating that the synthase contained a cytochrome P-450 type heme. It is now known that NO plays a critical role in signal transduction and in the immune response to infection. Applications of these findings include the ability to manipulate the NO signaling pathway as utilized in Viagra®, the ability to inhibit NO biosynthesis for the treatment of septic shock, and an understanding of the clinical tolerance that develops with continued use of vasodilators such as nitroglycerin. The finding that heme is a NO binding site has led to questions of oxygen versus NO binding. One of Dr. Marletta's current research problems is the development of proteins that can circulate in the blood and carry out its oxygen carrying functions without interfering with the critical role of NO. Such proteins would be candidates for the production of a blood substitute that could be stored as a package of dry chemicals which, upon addition of water, could be infused in the same manner as standard IV fluids.

The NO story with highly visible endpoints in medicine is a great vehicle to teach the positive values of chemistry. Dr. Marletta is an outstanding teacher who has parlayed that ability into communicating the value of fundamental chemical research to non-science audiences, including commencement addresses, the University of Michigan alumni lectures, and the Chautauqua Institution in New York. The latter talk, entitled “Disease and the Power of Discovery in the New Millenium”, was given to an audience of 4000. In addition, he has appeared on Horizon, the BBC equivalent of Nova, and continues speaking to general audiences in California

113 GUSTAVUS JOHN ESSELEN 1888-1952

Born in Roxbury, Massachusetts, Gustavus J. Esselen received his higher education at Harvard, where he was awarded the A.B. (magna cum laude) in chemistry in 1909 and the doctorate in 1912. In that same year he married Henrietta W. Locke, a chemistry graduate at Radcliffe. Their three children are Mrs. Bradford K. Bachrach, Mrs. George B. Hanson and Gustavus John III.

His professional career was devoted to chemical research, first with General Electric Co. in Lynn, Arthur D. Little, Inc. in Cambridge, and Skinner, Sherman and Esselen, in Boston. In 1930 he founded Gustavus J. Esselen, Inc., later known as Esselen Research Corporation. Over the years he successfully solved a variety of problems for industrial clients in such fields as plastics, synthetic fibers, paper, rubber, and glass. Among these was the development of anhydride curing agents for epoxy resins and polyvinyl butyral as an improved material for safety glass, both of which enjoyed considerable commercial success. More than 40 U.S. patents were issued as a result of his research efforts.

Esselen was an active member of the American Chemical Society for 43 years. He served two terms as chairman of the Northeastern Section (1922 and 1923) and was Councilor and Director at the National level. In 1948 he received the James Flack Norris Honor Scroll as "the person who has done most to advance the interests of the Northeastern Section."

He was the recipient of The Modern Pioneer Award from the National Association of Manufacturers in 1940, and in 1950 he was made an honorary member of the American Institute of Chemists in recognition of his services to the professions of chemistry and chemical engineering. He was Chairman of the American Section of The Society of the Chemical Industry of Great Britain, President of the American Council of Commercial Laboratories, Director of the Boston Chamber of Commerce and President of the Rotary Club of Boston.

Esselen's distinguished contributions to chemistry and chemical engineering were in accordance with the highest ethics of these professions; his recognition of the duties of a professional led to his exertion of a wise and beneficent influence on all the professional societies to which he gave so generously of his time and led to his active participation in church and civic activities in the Boston area.

Esselen was a very sensitive person, devoted throughout his life to the fine arts and music. His motto, contained on a tapestry in his office, was a quotation of Richard Wilstatter, "It is our destiny, not to create, but to unveil."

114

Program

Preprandial Hour and Dinner Harvard Faculty Club

Esselen Award Ceremonies Pfizer Lecture Hall Mallinckrodt Chemistry Laboratories

Chair, Northeastern Section Mukund Chorghade Welcome Robert S. Langer The Esselen Award Myron S. Simon Introduction of Michael Marletta Robert S. Langer Presentation of the Award Gustavus J. Esselen, IV Esselen Award Address Michael A. Marletta

“Nitric Oxide in Biology: From Discovery to Therapeutics."

The Esselen Award is made possible through an endowment by the Esselen Family in memory of Dr. Gustavus J. Esselen

PRIOR RECIPIENTS OF THE ESSELEN AWARD FOR CHEMISTRY IN THE PUBLIC INTEREST

F. Sherwood Rowland and Mario J. Molina ...... 1987 Discovery of the effect of chlorofluorocarbons on the ozone layer

Alfred P. Wolf and Joanna S. Fowler ...... 1988 Chemical methods used in positron emission tomography for medical diagnostics

Carl Djerassi ...... 1989 Contraception and the synthesis of the first birth control drug

Thomas J. Dougherty ...... 1990 Photodynamic therapy for treatment of malignant disease

Jerrold Meinwald and Thomas Eisner ...... 1991 Insect Chemistry and Human Welfare

Bruce N. Ames ...... 1992 Understanding the Causes of Aging and Cancer

James G. Anderson ...... 1993 Global Ozone Loss and its Prediction

Kary B. Mullis ...... 1994 The Polymerase Chain Reaction

Howard J. Schaeffer ...... 1995 Nucleosides with Antiviral Activity: Discovery of Acyclovir (Zovirax®)

Roy G. Gordon ...... 1996 Low-Emissivity Glass: Energy Conserving Windows

Rangaswamy Srinivasan ...... 1997 115 Ablative Photo Decomposition for Micromachining of Polymers and Biological Tissue

Kyriacos C. Nicolaou ...... 1998 Chemical Synthesis and Chemical Biology of Natural Substances

Robert S. Langer ...... 1999 The Development of Unique Polymers for Medical Applications

William A. Pryor ...... 2000 Vitamin E and the Prevention of Heart Disease

Joseph M. DeSimone ...... 2001 Green Chemistry for Sustainable Economic Development

Ronald Breslow ...... 2002 Chemistry Lessons from Biology and vice versa

Bruce D. Roth ...... 2003 The Discovery and Development of Lipitor®

James W. Jorgenson...... 2004 The Magic of Capillaries in Chemical Separations and Analysis

Jean M. J. Fréchet ...... 2005 Functional Macromolecules: From Design and Synthesis to Application

Richard D. DiMarchi ...... 2006 Chemical Biotechnology as a Means to Optimal Protein Therapeutics

116 NOMINATIONS SOUGHT

GUSTAVUS JOHN ESSELEN AWARD FOR CHEMISTRY IN THE PUBLIC INTEREST

The Esselen Award for Chemistry in the public interest is one of the most prestigious honors provided by the Northeastern Section of the American Chemical Society. The award annually recognizes a chemist whose scientific and technical work has contributed to the public well-being, and has thereby communicated positive values of the chemical profession. The Awardee should be a living resident of the United States or Canada at the time of nomination, and the significance of this work should have become apparent within the five years preceding nomination.

The Esselen Award has no limitations with respect to the chemical field in which the nominees are active. Since its inception, the award has been given to the following chemists (see over for subjects):

1987: F. Sherwood Rowland 1996: Roy G. Gordon Mario J. Molina 1997: Rangaswamy Srinivasan 1988: Alfred P. Wolf Joanna S. Fowler 1998: Kyriacos C. Nicolaou

1989: Carl Djerassi 1999: Robert S. Langer

1990: Thomas J. Dougherty 2000: William A. Pryor

1991: Jerrold Meinwald 2001: Joseph M. DeSimone Thomas Eisner 2002: 1992: Bruce N. Ames 2003: Bruce D. Roth 1993: James G. Anderson 2004: James W. Jorgenson 1994: Kary B. Mullis 2005: Jean M. J. Fréchet 1995: Howard J. Schaeffer 2006: Richard D. DiMarchi

THE AWARD CONSISTS OF A MEDAL AND A CHECK FOR $5,000. Travel expenses incidental to the conferring of this award will be reimbursed. The award will usually be held in Cambridge, Massachusetts at the April meeting of the Northeastern Section. The Awardee will deliver an address on the subject of the work for which the honor is being conferred, or for work in progress which is also directed to chemistry in the public interest.

TO NOMINATE a candidate please provide statements from two co-sponsors as well as a brief biography of the candidate, a description of the work which has been recognized as communicating the positive values of the chemistry profession, and copies of selected, pertinent articles. Popular news and feature articles should be included as an indication of public interest. Nominations and inquiries should be directed to Dr. Robert S. Langer, c/o Karen Piper, 19 Mill Road, Harvard, MA 01451. NOMINATIONS SHOULD BE POSTED NO LATER THAN OCTOBER 15, 2006. Joint nominations are acceptable. The Committee will review the nominations and the award recipient will be notified by the first of February.

117

PAST-AWARDEES AND TITLES OF AWARD ADDRESSES

1987: F. Sherwood Rowland, University of California at Irvine, and Mario J. Molina, now at the Massachusetts Institute of Technology. Discovery of the Influence of Chlorofluorocarbons on the Ozone Layer.

1988: Alfred P. Wolf and Joanna S. Fowler, Brookhaven National Laboratories, Chemical

Procedures to Make Positron Emission Tomography a Practical Method in Medical Diagnosis.

1989: Carl Djerassi, Stanford University. Synthesis and Promotion of the First and Most

Common Birth Control Hormone.

1990: Thomas J. Dougherty, Roswell Park Cancer Institute. The Development of Photodynamic

Therapy for the Treatment of Malignant Disease

1991: Jerrold Meinwald and Thomas Eisner, Cornell University. Chemical Responses in the

Insect and Plant World.

1992: Bruce N. Ames, University of California at Berkeley. Methods for Detection of

Carcinogens and Causes of Aging and Cancer.

1993: James G. Anderson, Harvard University. Experimental Methods for Measuring Global

Ozone Loss.

1994: Kary B. Mullis. The Discovery of Polymerase Chain Reactions (PCR) for the

Replication of DNA Molecules.

1995: Howard J. Schaeffer, Burroughs Wellcome Company. Nucleosides with Antiviral

Activity - The Discovery of Acyclovir (Zovirax®).

1996: Roy G. Gordon, Harvard University, Low Emissivity Glass; Energy Conserving

Windows.

1997: Rangaswamy Srinivasan, UVTech Associates, The Widely Used Laser Methodology of

Tiny Focused Ablative Photodecomposition.

1998: Kyriacos C. Nicolaou, Scripps Research Institute, Chemical Synthesis and Chemical

Biology of Natural Substances

1999: Robert S. Langer, Massachusetts Institute of Technology, The Development of Unique

Polymers for Medical Applications.

2000: William A. Pryor, Louisiana State University, Vitamin E and the Prevention of Heart

Disease.

2001: Joseph M. DeSimone, University of North Carolina and North Carolina State University,

Green Chemistry for Sustainable Economic Development.

2002: Ronald Breslow, Columbia University, Chemistry Lessons from Biology and vice versa.

2003: Bruce D. Roth, Pfizer Global Research & Development, The Discovery and

Development of Lipitor® (Atorvastatin Calcium).

118

2004: James W. Jorgenson, University of North Carolina, The Magic of Capillaries in Chemical Separations and Analysis

. 2005: Jean M. J. Fréchet, University of California at Berkeley, Functional Macromolecules: From Design and Synthesis to Applications.

. 2006: Richard D. DiMarchi, University of Indiana, Chemical Biotechnology as a Means to Optimal Protein Therapeutics

.

7068 Dr. Mukund Chorghade, 2007 NESACS Chair, with Mrs. Veena Chorghade, Dr. Laura Langer and Dr. Robert Langer, MIT, 2007 Chair of the Esselen Award Committee and 1999 Esselen Awardee.

07111 Dr. Robert Langer and Dr. Michael Marletta before the award ceremony.

119

07110 (l to r) Dr. Robert Langer, Dr. Michael Marletta, and Dr. Mukund Chorghade before the award ceremony at Mallinckrodt Laboratories, Harvard University.

07160 Gustavus J. Esselen IV presents the 2007 Award to Professor Michael Marletta, Aldo de Benedictus Distinguished Professor of Chemistry and Chair of the Chemistry Department, University of California, Berkeley

120

07166 Professor Marletta introduces his award address “Nitric Oxide in Biology: From Discovery to Therapeutics”

All Esselen Award pictures are by Fritzsche Photography

121

122

Fund-Raising Committee Dorothy J. Phillips, Chair

2007 Northeastern Section of ACS (NESACS) Fund-Raising Activities

Summary: $25,957 raised (details in Table 1)

6. Third Annual Golf-Tournament was held during ACS national meeting in Boston, August 2007. Funds came from the contributions made by companies as sponsors of holes. Each golfer paid a fee to play. ACS Women Chemist Committee was also a sponsor. 7. NESACS Vendor Fair was held March 30, 2007 at the Advances in Chemical Science Symposium in Cambridge, MA. 8. Corporate solicitation was made from current contributors (see list in Nucleus) and new scientific companies in geographical proximity to the Section. 9. NESACS YCC raised funds to support the German Exchange program. 10. Merck made a contribution to NESACS National Chemistry week program.

Dorothy J. Phillips, Chair, Fundraising Committee, thanks all organizers of the above activities.

Table 1: Contributions March 30 Adv in Chemical Science Symposium Pfizer $2,000.00 Ziopharm Oncology Inc $1,000.00 Vertex Pharmaceuticals $1,000.00 AstraZeneca $1,000.00 Royal Soc of Chemistry $750.00 Millennium Pharmaceutical $1,000.00 Novartis $2,000.00 Wyeth $500.00 Serono Repro Inst $885.00 Abbott Laboratories $2,000.00 YCC Career Day and Research Symposium Vertex Pharma $900.00 AstraZeneca $500.00 Golf Sponsors Wm Carroll $500.00 Lyophilization of NE $7,500.00 Strem Chemicals $1,000.00 PCI Synthesis $300.00 Cambridge Major Labs $500.00 Vertex Pharma $500.00 Irix Pharmaceuticals $1,000.00 Zink, Inc. $1,000.00 123

ACS Women Chemist Committee $3,695.00 National Chemistry Week Merck $2,000.00 German Exchange Program Strem Chemicals $5,000.00 Total $36,530.00 Fundraising expenses Golf Outing $10,573.07 Net $25,956.93

From the Nucleus

Fund Raising - Golf Tournament

The first place team! (L-R) Paul Delfino, Jim Bannister, Stu Needleman receiving their award from Harry Mandeville.

Second place team: (L-R) Damon Abernathy,Aimee Hodge and Matt Halvorsen with Harry Mandeville

124

Third place team: (L-R) Geoff Tapper, Amy Tapper, Panos Kalaritis, and Harry Mandeville.

Signage for one of the sponsors of the tournament: Occidental Petroleum. Represented at the tournament by past-ACS President, Bill Carroll

Closest to the pin- Perry Catchings of Closest to the pin- Amy Tapper of Prime Momenta Organics of Woburn. Pharmaceuticals, Inc.

125

Corporate contributors as listed in the Nucleus, December, 2007, Vol. LXXXVI, No. 4

Corporate Patrons ($2,000+) Abbott Laboratories Lyophilization Service of New England Merck National ACS Novartis Pfizer Sepracor Vertex Pharmaceuticals

Patrons ($1,000 - $1,999) Astra Zeneca R&D Boston IRIX Pharmaceuticals Millennium Pharmaceuticals Shasun Pharmaceuticals Strem Chemicals, Inc. ZINK Imaging Ziopharm Oncology, Inc.

Donors ($300 - $999) Cambridge Major Laboratories Occidental PCI Synthesis Royal Society of Chemistry Serono Research Institute Wyeth Pharmaceuticals

126

REPORT OF THE GOVERNMENT RELATIONS COMMITTEE - 2007 Doris I. Lewis, Chair

Members: Michael Hearn, Tim Rose, Michael Strem, Doris Lewis, Peter Jacobi, , Chris Moreton, Liming Shao, Pamela Nagafuji, Don Rickter, Michael Singer.

In 2007 our Section had four active participants in the ACS Joint Board-Council Committee on Chemistry and Public Affairs, Dr. Michael J.Hearn, Timothy L. Rose, Peter Jacobi and Doris Lewis. All are members of the Legislative Action Network which send letters to Congress in support of ACS positions, as are many other members of the Northeastern Section. Additionally, Mike Strem has been active in contacting his congressman, Rep. Tierney.

Dr. Rose, Dr. Jacobi, and Dr. Lewis attended the CCPA meeting April 23 and 24 in Washington, and also attended the 4th annual ACS Legislative Summit March 25-26. All were members of a team advised by ACS OLGA Staff member Ray Garant. Congressional offices visited were: Rep. Barney Frank (constituent, Doris Lewis); Marty Meehan (constituent Tim Rose); Nita Lowey(D-NY), constituent Anne O’Brien; Senator Gregg, constituent Peter Jacobi; Senator Hillary Clinton, constituent Ron Breslow; Rep. Paul Hodes, constituent Peter Jacobi. The theme for the visit was innovation and competitiveness, specifically advocating an increase in funding for basic physical science at NSF, DOE Office of Science, and NIST core; funding increase for math and science education programs proposed under the American Competitiveness Initiative at NSF and the Department of Education; and the Math and Science Partnership programs at NSF and the Department of Education. Shortly after these meetings, we were delighted to learn that The House approved H.R. 362, the 10,000 Teachers, 10 Million Minds Science and Math Scholarship Act, and by a vote of 88 to 8 the Senate passed the America Competes Act. The House Committee on Science & Technology also approved their bill to reauthorize programs at the National Science Foundation..

Dr. Hearn, Dr. Lewis, Dr. Rose, and Dr. Jacobi attended the September 10 meeting in San Francisco of CCPA and of its work groups. Dr. Rose is a member of the Policy Work Group, Dr. Lewis is a member of the Grassroots Work Group, which Dr. Hearn is chair, and Dr. Jacobi is a member of the Fellowships Work Group. In addition to the work group activities, and reports on the presidential task force and the state advocacy program, the committee was addressed by speaker Luis Echegoyen, Director, NSF Chemistry Division.

In keeping with the OLGA state advocacy program, NESACS has increased activity with the state legislature. Doris Lewis and Susan Brauner, member of the Brauner Lecture Committee, met with Casey Rose Shevin, legislative aide to Senator Robert O’Leary, Chair of the Senate Committee on Higher Education and member, Senate Committee on Environment, Natural Resources, and Agriculture. Ms. Shevin was very helpful in giving guidance on effective ways of dealing with the state legislature, giving us a number of contact names, and pleased to be made aware of the resources that NESACS could offer. We gave her current ACS fact sheets regarding science funding and outcomes in Massachusetts for the Senator’s use in supporting current innovation and competitiveness legislation in Massachusetts.

Committee member Tim Rose and NESACS Councilor Don Rickter have been active in following The Safer Alternatives Bill (An Act for a Healthy Massachusetts: Safer Alternatives to Toxic Chemicals, passed by the Massachusetts Senate on February 8). Led by Senator Steven Tolman (D-Brighton) and Senator Pam Resor (D- Acton), efforts to move the bill forward in the Senate gained momentum in the wake of last year's product recalls over hazardous ingredients such as lead in children's toys and lipstick. It is supported by the Alliance for a Healthy Tomorrow (AHT), a coalition of over 160 organizations -health, labor, scientific, environmental, faith and community groups - working to promote the use of safer alternatives to toxic chemicals where feasible. ACS does not have an official position on the bill, but Dr. Rickter has kept in close touch with Bob Ross, Chief Policy Advisor for the Senate President and with his state rep, Jim Marzilli, who was elected to the state Senate in

127

December, and has kept this committee and the NESACS board up-to-date on the progress of the bill. We have also made Caroline Trupp Gill of OLGA aware of the legislation.

Respectfully submitted, Doris Lewis

REPORT OF THE LOCAL ARRANGEMENTS COMMITTEE – 2007 Mary Burgess, Chair

The following is data for the meetings held during 2006:

Date Location No. Program / Speaker Notes

1/18 Harvard University 66 Dr. Yvonne Connolly Martin Joint with BAGIM Abbott Laboratories (retired) Boston Area Group for Informatics & Modeling 2/8 Harvard University 46 Jeannette Elizabeth Brown Educational Consultant

3/9 Univ. of Mass. Boston 33 Prof. Michael R. Wasielewski Norris Awardee in Northwestern University Organic Chemistry (ACS)

4/12 Harvard University 77 Dr. Michael A. Marletta Esselen Award University of California Berkeley

5/10 Northeastern University 89 Dr. Steve Jones Education Awards Sepracor, Inc.

5/17 Emmanuel College 34 Lead Optimization Strategies MCG Symposium

9/20 Holiday Inn / Woburn 36 Building Bridges between the Joint with MCG Pharmaceutical Industry & Academia -- A New Paradigm for Drug Discovery

10/18 Univ. of Mass. Boston 40 Dr.Mukund Chorghade Hill Award / Chorghade Enterprises / 50-Yr. Members THINQ Pharma

11/8 Harvard University 73 Prof. Diane M. Bunce Norris Award The Catholic University of America Heyn Book Prize

12/12 Holiday Inn / Woburn 66 Signal Transduction Targets and Joint with MCG Drug Discovery

Note: The numbers shown in column three represent the number of people who registered to attend the dinner. Additional people were present to hear the speakers but are not included in these counts.

128

2007 Annual Report from Medicinal Chemistry Group Dr. Raj (SB) Rajur, Program Chair for Medicinal Chemistry Division, NESACS.

The medicinal chemistry division is one of the active divisions of NESACS that conducted three excellent symposia during the year 2007. The first symposium was held on May 17, 2007 at Emmanuel College, Boston MA. The symposium topic was Lead Optimization Strategies. The meeting started with the welcome speech from the program chair Dr. Raj (SB) Rajur followed by introductory remarks by Dr. Norton Peet. Prof. L.V. G Nargund of Nargund Research Foundation, & Nargund College of Pharmacy, Bangalore, India, spoke on Green Chemistry and use of microwave technologies in small molecule synthesis. Dr. Neal Green from Wyeth Research, Cambridge, MA, spoke on Inhibitors of Tpl2 Kinase and TNF Production: Selectivity and In Vivo Antiinflammatory Activity of Novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles. The third speaker for the day was Dr. Horst Hemmerle, from Eli Lilly and Co. Indianapolis, who spoke on Use of relevant Chemical Diversity in Drug Discovery.

The keynote speaker for the symposium was Dr. Mark T. Goulet from Merck Research Laboratories, Boston, MA. Dr. Goulet’s talk was focused on Lead Optimization of Orally Bioavailable Drugs. The meeting was well attended and there were more than 100 participants present at this symposium.

The second symposium titled, Building Bridges between the Pharmaceutical Industry and Academia – A New Paradigm for Drug Discovery, was held on September 20, 2007 at Holiday Inn Hotel in Woburn MA. There were 100 participants who enjoyed cutting edge research results that were presented by four well-known speakers from the pharmaceutical industry. Dr. David Weaver, director of new leads discovery, Vanderbilt University spoke on New Frontiers in Exploratory and Early Drug Discovery Research. Dr. Greg Cuny, Director of Laboratory for Drug Discovery in Neurodegeneration at Harvard Medical School spoke on Opportunities and Challenges for Medicinal Chemistry in Academic Drug Discovery. Dr. Perry F. Renshaw, Principal Investigator and Program Director at McLean Hospital Brain Imaging Center, spoke on In Vivo Magnetic Resonance Spectroscopy in Drug Discovery and Development. The social hour, networking and dinner were part of the program. The keynote speaker for the evening was Dr. Iwao Ojima, distinguished Professor and Director of Institute of Chemical Biology & Drug Discovery at State University of New York at Stony Brook, spoke on Opportunities for Translational Research in Chemical Biology and Drug Discovery. The program chair, Dr. Liming Shao of Sepracor welcomed the guests and participants. Dr. Tom Large, VP of Drug Discovery, Sepracor Inc. moderated the symposium. The symposium was concluded with the token of respect to the speakers by the program Chair, Dr. Shao.

The third and the last symposium for the year 2007, was held on December 12, 2007 at Holiday Inn Hotel in Woburn, MA. This meeting was a big success. There were more than 100 participants who enjoyed cutting edge research results that were presented by four well-known speakers. The topic of the symposium was on Signal Transduction Targets and Drug Discovery. Dr. Hariprasad, V, Director of Medicinal Chemistry, SuperGen, Inc. Salt Lake City, UT, spoke on Discovery of MP-529: A Selective Inhibitor of Aurora 2 Kinase in Development for the Treatment of Cancer. Dr. Adrian D Hobson, Group Leader, Global Pharmaceutical Discovery, Abbott Bioresearch Center, Worcester, MA Spoke on Hit To Lead Case Studies. Dr. Vinod F. Patel, Director of Medicinal Chemistry, Amgen Inc., Cambridge, MA spoke on the Discovery of Motesanib (AMG 706), a Multi- Kinase Angiogensis Inhibitor for Treatment of Human Cancers: From Crystal to Clinic. The social hour, networking and dinners were part of the program.

The keynote speaker for the evening was Dr. Tomi Sawyer, Chief Scientific Officer and Senior VP of drug discovery, Aileron Therapeutics, Cambridge, MA. Dr. Sawyer spoke on Exploring Chemical Space in Protein- Protein Interaction Drug Discovery: Bridging Nature to Breakthrough Medicines. Dr. Raj (SB) Rajur, Chairman

129

and CEO of CreaGen Biosciences, Inc. Woburn, the Program Chair for the division, welcomed the guests and gave an introductory presentation and moderated the symposium.

The symposium was concluded with the token of respect to the speakers by the program Chair, Dr. Rajur.

May 2007 Meeting

Meeting of the Medicinal Chemistry Group Northeastern Section

Of the American Chemical Society Northeastern Section of the American Chemical Society

Symposium LEAD OPTIMIZATION STRATEGIES

Organized by the Medicinal Chemistry Group Thursday - May 17, 2007 Emmanuel College, 400 The Fenway Boston, MA 02115

3.00 Refreshments 3.15 pm Welcome Raj (SB) Rajur, Program Chair, CreaGen Biosciences, Inc, Woburn, MA 3.20 pm Introductory Remarks Norton Peet, International R&D Consultant, North Andover, MA 3.30 pm Green Chemistry: Synthesis of Small Molecules by Microwave Technique Prof. L.V. G Nargund, Nargund Research Foundation, Nargund College of Pharmacy, Bangalore, India 4:15 pm Inhibitors of Tpl2 Kinase and TNF Production: Selectivity and In Vivo Antiinflammatory Activity of Novel 8-substituted-4-anilino-6- aminoquinoline-3- carbonitriles Neal Green, Wyeth Research, Cambridge, MA 5:00 pm Use of relevant Chemical Diversity in Drug Discovery Horst Hemmerle, Discovery Chemistry, Eli Lilly and Co. Indiana Polish, IN 5.45 pm Social Hour 6.30 pm Dinner 7.45 pm Lead Optimization of Orally Bioavailable Drugs Mark T. Goulet, Merck Research Laboratories, Boston, MA

Dinner reservations should be made no later than 12:00 noon on Thursday, May 10, 2007. Please contact Marilou Cashman

THE PUBLIC IS INVITED

130

Prof. L. V. G. Naragund Green Chemistry: Synthesis of Small Molecules by Microwave Technique Microwave assisted synthesis in Lead optimization studies will be presented ______

Dr. Nargund is the founder of Nargund Research Foundation and now serving as the principal of Nargund College of Pharmacy. He received his Ph.D from Karnataka University Dharwad, India in synthetic organic chemistry. Dr. Nargund has published over 50 peer reviewed articles in national and international journals.

______

Neal Green Inhibitors of Tpl2 Kinase and TNF Production: Selectivity and In Vivo Antiinflammatory Activity of Novel 8- substituted-4-anilino-6-aminoquinoline-3-carbonitriles

Tpl2 (Cot/MAP3K8) is a serine/threonine kinase in the MAP3K family directly upstream of MEK. Recent studies using Tpl2 knockout mice have indicated an important role for Tpl2 in the LPS-induced production of TNF and other pro- inflammatory cytokines involved in such diseases as rheumatoid arthritis. Initial 4-anilino-6-aminoquinoline-3-carbonitrile leads showed poor selectivity for Tpl2 over EGFR kinase. Using molecular modeling and crystallographic data of the EGFR kinase domain of with and without an EGFR kinase-specific 4-anilinoquinazoline inhibitor (Erlotinib, TarcevaTM), we hypothesized that we could diminish the inhibition of EGFR kinase by substitution at the C-8 position of our 4-anilino- 6-aminoquinoline-3-carbonitrile leads. The 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles were prepared from the appropriate 2-substituted-4-nitroanilines. Modifications to the C-6 and C-8 positions led to the identification of compounds with increased inhibition of TNF release from LPS-stimulated rat and human blood and these analogs were also highly selective for Tpl2 kinase over EGFR kinase. Further structure-activity based modifications led to the identification of 8-bromo-4-(3-chloro-4-fluorophenylamino)-6-[(1-methyl-1H-imidazol-4-yl)methylamino]quinoline-3-carbonitrile which demonstrated in vitro as well as in vivo efficacy in inhibition of LPS-induced TNF production

Neal Green, Senior Scientist at Wyeth Pharmaceuticals, received a B.S. in medicinal chemistry and graduated cum laude from SUNY Buffalo, and earned his Ph.D. from Rensselaer Polytechnic Institute. In 1993, he was awarded a fellowship from the NIH to study Novel Lactonization Methodologies and Total Synthesis of Rhizoxin. In 1994 Dr.Green joined Genetics Institute as staff scientist. Currently he is leading a chemistry team at Wyeth Research in Cambridge MA. Dr. Green’s research interests are in the areas of TNF signal transduction pathways and inhibition of T-cell co-stimulation. ______Horst Hemmerle Use of relevant Chemical Diversity in Drug Discovery Lilly developed a number of strategies to address Lead Generation for Drug Discovery. Knowledge based enrichment of the compound collection combined with target family focused informatics allowed to dramatically increase screening efficiencies. ------Horst Hemmerle studied Bioorganic Chemistry in Germany and joined the pharma division of Hoechst AG (later part of Aventis) in 1990 as a research scientist in the metabolic disorders group. In 1996 he continued his career as a head of medicinal chemistry at Hoechst-Marion-Roussel in Frankfurt. Dr. Hemmerle joined Lilly in 2001 as a head of medicinal chemistry. He played a critical role in fostering lead generation as a critical step in the drug discovery process. During the first 3 years he had completely re-engineered Lilly’s strategy for rebuilding the Lilly compound collection with a focus on knowledge-based design and quality. Under his leadership and vision, the Platform Library Sciences has grown to be a global activity involving the coordination of internal science as well as an extended network of external collaborators and vendors. The impact of this initiative is being realized across multiple new target discovery efforts. Dr. Hemmerle has also been instrumental in bringing new paradigms for medicinal chemistry automation and computational drug discovery to Lilly. Since 2003 he is leading as a Director the broader discovery technology function first for the lead generation phase and since 2005 throughout the entire Discovery phase to clinical candidate. ______

131

Mark T. Goulet Lead Optimization of Orally Bioavailable Drugs Lead optimization is fundamentally an application of the scientific method within the realm of compound design-for- function. In addition to synthetic chemists, this process involves scientists who can measure relevant compound properties and an informatics system in which to store data and aid in the assimilation of new SAR knowledge. Most of the properties being optimized in this process relate to the individual drug molecule and its interaction with protein targets and off-targets. Understanding the metabolic fate of compounds within the liver is often vital to the discovery of an orally bioavailable and safe drug. This presentation describes two recent drug discovery programs at Merck Research Laboratories and the key role that understanding metabolic fate played in their success.

Mark Goulet, Executive Director of Drug Design & Optimization at Merck Research Laboratories in Boston, Massachusetts, received a B.S. degree in Chemistry from the University of Michigan and a Ph.D. in Chemistry from Yale University. He joined Merck at the Rahway, New Jersey, site in 1987 and in 2004 moved to Boston at the opening of this research facility. During his career, Dr. Goulet has headed medicinal chemistry teams working to develop new therapies for organ transplant rejection, endometriosis, obesity and atherosclerosis. Current interests include the discovery of breakthrough medicines for the treatment of cancer and Alzheimer's disease.

September 2007 Meeting

th 880 Meeting

of the Northeastern Section

Northeastern Section American Chemical Society

of the

American Chemical Society

Symposium BUILDING BRIDGES BETWEEN THE PHARMACEUTICAL INDUSTRY AND ACADEMIA -- A NEW PARADIGM FOR DRUG DISCOVERY Organized by the Medicinal Chemistry Group, NESACS

Thursday - September 20, 2007 Holiday Inn 15 Middlesex Canal Park Road - Woburn, MA

2:45 pm Refreshments 3.00 pm Welcome Liming Shao, Ph.D. - Chair, Medicinal Chemistry Group, NESACS 3.05 pm Introductory Remarks & Moderator Tom Large, Ph.D., - VP, Drug Discovery, Sepracor, Inc. 3.20 pm New Frontiers in Exploratory & Early Drug Discovery Research: A Hybrid Academic/ Industrial Approach -- David Weaver, Ph.D., Director, New Leads Discovery, Vanderbilt Program in Drug Discovery, Vanderbilt University 4:05 pm Opportunities & Challenges for Medicinal Chemistry in Academic Drug Discovery -- Greg Cuny, Ph.D., Director, Laboratory for Drug Discovery in Neurodegeneration, Harvard Medical School 4:50 pm In Vivo Magnetic Resonance Spectroscopy in Drug Discovery & Development -- Perry F. Renshaw, M.D., Ph.D., Principal Investigator/Program Director, McLean Hospital Brain Imaging Center, Harvard University 5.40 pm Social Hour 6.30 pm Dinner

132

7.45 pm Opportunities for Translational Research in Chemical Biology & Drug Discovery -- Iwao Ojima, Ph.D., Distinguished Professor and Director, Institute of Chemical Biology & Drug Discovery, State University of New York at Stony Brook Dinner reservations should be made no later than 12:00 noon on Thursday, September 13, 2007. Please contact Marilou Cashman at (800) 872-2054 or (508) 653-6329 or [email protected] to make dinner reservations. Reservations not canceled at least 24 hours in advance must be paid. Members, $28.00; Non- members, $30.00; Retirees, $15.00; Students, $10.00. Anyone who needs handicapped services/transportation, please call a few days in advance so that suitable arrangements can be made.

Please use the following link for directions to Holiday Inn: http://www.ichotelsgroup.com/h/d/sl/1/en/hotel/BOSMS/transportation

THE PUBLIC IS INVITED

December Meeting

The 883rd Meeting Northeastern Section

of the American Chemical Society

Northeastern Section

of the

American Chemical Society

JOINT MEETING: NORTHEASTERN SECTION, ACS AND MEDICINAL CHEMISTRY GROUP

Symposium Signal Transduction Targets and Drug Discovery Organized by the Medicinal Chemistry Section of the Northeastern Section, American Chemical Society

Wednesday - December 12th, 2007 Holiday Inn, 15 Middlesex Canal Park Road, Woburn, MA

3.00 pm Refreshments 3.15 pm Welcome Raj (SB) Rajur, Program Chair, CreaGen Biosciences, Inc. Woburn, MA 3.20 pm Introductory Remarks Norton Peet, International R&D consultant, North Andover, MA 3.30 pm Discovery of MP-529: A Selective Inhibitor of Aurora 2 Kinase in Development for the Treatment of Cancer. Hariprasad, V, Director of Medicinal Chemistry, SuperGen, Inc. Salt Lake City, UT 4:15 pm Hit To Lead Case Studies Adrian D Hobson, Group Leader, Global Pharmaceutical Discovery, Abbott Bioresearch Center, Worcester, MA 5:00 pm The Discovery of Motesanib (AMG 706), a Multi-Kinase Angiogensis Inhibitor for

133

Treatment of Human Cancers: From Crystal to Clinic Vinod F. Patel, Director of Medicinal Chemistry, Amgen Inc., Cambridge, MA 5:45 pm Social Hour 6:30 pm Dinner 7:45 pm Exploring Chemical Space in Protein-Protein Interaction Drug Discovery: Bridging Nature to Breakthrough Medicines Tomi Sawyer, Chief Scientific Officer and Senior VP of drug discovery, Aileron Therapeutics, Cambridge, MA Dinner reservations should be made no later than 12:00 noon on Thursday, December 6th, 2007. To, please contact Marilou Cashman at (800) 872-2054 or (508) 653-6329 or [email protected]. Reservations not canceled at least 24 hours in advance must be paid. Members. Anyone who needs handicapped services/transportation, please call a few days in advance so that suitable arrangements can be made. Reservations not canceled at least 24 hours in advance must be paid. Payment is made at the door by cash or check (no credit cards.) Members, $28.00; Non-members, $30.00; Retirees, $18.00;Students, $10.00. Directions to Holiday Inn Hotel A. From Boston - Cambridge - Points North: Take Route I-93 to Route 95/128 West. After 1 mile, take Exit 35 South to Route 38 (Main Street). *After about 500 feet at the traffic light, turn right into Middlesex Canal Street to the hotel entrance. B. From the West: Take Route 95/128 North to Exit 35 South (Route 38 - Main Street. Follow directions from * above.

THE PUBLIC IS INVITED Hariprasad V Discovery of MP-529: A Selective Inhibitor of Aurora 2 Kinase in Development for the Treatment of Cancer.

One of the important targets for discovering new therapeutics for treating various cancer disease is represented by Aurora kinases, a family composed of three Ser/Thr protein kinases such as Aurora-A, B, and C. Aurora kinases play a crucial role in proper spindle formation at mitosis. Overexpression of Aurora-A leads to dysregulation of the centrosome cycle resulting in the formation of multipolar mitotic spindles. The resulting abnormal mitotic events lead to genomic instability which is an underlying process in tumorigenesis. Inhibition of the Aurora kinase activity in tumor cell lines typically leads to the accumulation of polyploidy cells, apoptosis, and block of proliferation. As a part of our oncology drug development program to identify small molecule kinase inhibitors, we have initially identified a very selective sub-nanomolar inhibitor of the pyrimido[4,5-b]indole class of Aurora A kinase using a de novo fragment-based design strategy by utilizing X-ray crystal structure of an Aurora-A kinase. To further validate the inhibitory effect of this initial lead molecule, it was subjected to several cell-based assays in which it exhibited activity in the mid- to high-micromolar range. These results suggest that the lead compound is effectively hitting the intended cellular target and that lead optimization will likely be required to produce greater cellular potency. Therefore, we have employed lead optimization and successfully synthesized several compounds that led to the identification of MP-529 potent and selective Aurora A kinase inhibitor that belong to pyrimido[4,5-b]indoles series. Based on its high Aurora-A selectivity and antiproliferative activity on different cancer cell lines, favorable chemicophysical and pharmacokinetic properties, and high efficacy in in-vivo tumor models, the compound MP-529 was ultimately selected for further development. ______Dr. Hariprasad V received PhD degree in Pharmaceutical sciences UDCT, University of Bombay, India. He moved to US as a post- doctoral fellow in the labs of Professor Hurley, at College of Pharmacy, Arizona cancer center, Tucson AZ. Presently, he serves as Director of Medicinal Chemistry at SuperGen Inc. Salt lake city, UT. His research interest is in Synthesis of small Molecule Heterocyclics as Kinase Inhibitors and Topoisomerase-II and G-quadruplex interactive agents. Dr. Hariprasad has published over 50 peer reviewed articles in national and international journals and holds several patents. ______

Adrian Hobson "Hit To Lead Case Studies".

The talk covers the formalization of the Hit to Lead process. Using case studies, with and without structural information, it demonstrates how parallel synthesis can be leveraged to expedite the HTL process."

134

______Adrian Hobson received his PhD in organic chemistry from University of Sheffield (UK) under the supervision of Dr. C.M. Marson. He then joined Knoll Ltd as a principle scientist where he was responsible for the all the medicinal chemistry activities. In early 2000, Dr. Hobson accepted a team leader position at Abbott Bioresearch Center, Worcester where, over the next 5 years, he was mainly involved in the hit to lead generation program. Presently, he serves as group leader and manages Hit to Lead team. ______

Vinod F. Patel The Discovery of Motesanib (AMG 706), a Multi-Kinase Angiogensis Inhibitor for Treatment of Human Cancers: From Crystal to Clinic

Structure-guided approach to the discovery of a potent and highly selective VEGF-R2 inhibitor, AMG 706 will be presented. The preclinical properties that led to its selection as a development candidate and the subsequent initial Phase I experience with AMG 706 will also be discussed. ______

Vinod Patel received a B.Sc. degree (First Class Honors) in Applied Chemistry from Leicester Polytechnic (UK) and a Ph.D. in Organic Chemistry from Nottingham University (UK) under the supervision of Professor Gerry Pattenden. He moved to the US as a postdoctoral fellow in the labs of the late Professor Dick Schlessinger at University of Rochester (NY), where he was engaged in the Total Synthesis of Natural Products. In 1990, Dr. Patel accepted a position at Eli Lilly & Co. (Indianapolis) where, over the next 9 years, he was principally involved in discovering and developing oncolytics. In early 1999, he returned to the east coast to join Kinetix Pharmaceuticals (Medford, MA), a start-up firm specializing in Kinase Research. In late 1999, Amgen acquired Kinetix and Vinod accepted the role of Head of Medicinal Chemistry at the newlyopened Amgen Cambridge Research Center (CRC). Over the past 7 years at AMA, he has contributed to the growth of the site, especially the medicinal chemistry group, and has had the privilege of leading the KDR program that discovered AMG 706. Presently, he serves as Director of Medicinal Chemistry and manages a group of medicinal chemists with interests in Neuroscience and Oncology drug discovery programs. ______

Tomi Sawyer Exploring Chemical Space in Protein-Protein Interaction Drug Discovery: Bridging Nature to Breakthrough Medicines

Protein-protein interactions have incredible scope in the modulaton of biological activities and disease mechanisms. Inhibition or mimicry of such protein-protein interactions with small-molecules or natural products has been incredibly challenging, whereas peptide/protein strategies have been limited by cell penetration and in vivo pharmacological properties. Nevertheless, there exists a significant potential to develop a new class of drugs that are capable of modulating proteinprotein interactions to switch "off" or "on", for example, signal transduction pathways in many disease states. Examples of therapeutic targets as well as pioneering research to advance drug discovery will be described. Exploring known proteinprotein interactions has revealed that alpha-helical protein ligand/receptor type binding mechanisms are key to such molecular recognition processes. Noteworthy has been recent investigations providing proof-of-concept that synthetic alphahelical peptides are capable to bind and modulate specific therapeutic targets utilizing protein-protein interaction. Furthermore, hydrocarbon bridging of key alpha-helical peptides has advanced a first-generation series of promising class of biologics possessing unique cell-penetrating and in vivo pharmacological efficacies. Examples of such "stapled" alpha-helical peptides that mimic the BH3 domain alpha-helix of BID, a pro-apoptotic BCL-2 family member will be highlighted with respect to their effective in vitro and in vivo anti-cancer activities for leukemias. The significance of this concept and technology platform to exploit chemical space in protein-protein interaction drug discovery suggests an extraordinary opportunity for bridging nature to breakthrough medicines. ______

135

Tomi Sawyer recently joined AILERON Therapeutics (Cambridge) as Chief Scientific Officer and Senior Vice-President of Drug Discovery and Innovative Technologies. He will lead AILERON's development of a first-generation of breakthrough medicines directed at intracellular protein-protein interaction targets by leveraging a proprietary "stapled peptide" technology platform with application for the treatment of cancer and other diseases. Tomi was previously Senior Director, Pfizer Research Technology Center (Cambridge) and concurrently served on Pfizer’s Global Chemistry Leadership Team. Prior to Pfizer, Dr. Sawyer held several leadership positions in drug discovery at ARIAD Pharmaceuticals including Senior Vice-President, Drug Discovery, where he led chemistry campaigns which successfully advanced the mTOR inhibitor AP23573 (recently partnered with Merck) and the second-generation Src/Abl kinase inhibitor AP24534 (a clinical candidate). He began his career at The Upjohn Company as a peptide chemistry and drug design scientist before moving on to a position at Parke-Davis/Warner-Lambert Company where he last served as Head, Structure- Based Design Chemistry. Dr. Sawyer is the recipient of several international academic and corporate awards for outstanding drug discovery and innovative technologies. He is an inventor of more than 60 issued or filed scientific patents and is an author of more than 200 scientific publications including books, reviews, commentaries and research articles. Dr. Sawyer currently holds academic and research advisory appointments at the University of Massachusetts Medical School and the University of Massachusetts-Amherst. He is the Founding Editor-in-Chief of Chemical Biology & Drug Design. Dr. Sawyer received a B.Sci. with Honors in chemistry from Moorhead State University and a Ph.D. with Distinction in organic chemistry from the University of Arizona.

Membership Committee Michaeline Chen, Chair 2007 NESACS Annual Report

A total of 1182 “Welcome New Member” letters were sent during 2007.

Month Date New Transferred Totals Members Members January 4 36 32 68 February 17 96 44 140 March April May August 21 134 28 162 September 22 99 67 166 October 14 368 96 464 November 16 73 33 106 December 18 41 35 76 847 335 1182

Totals 847 335 1182

There were about 40 new members who attended our Local Section Dinner Meetings during 2007

The purpose of the membership committee is to welcome new members, assist and support our members in need and refer them to the appropriate resources; monitor membership in our section and recommend chemists and chemical scientists for membership. I have always provided Membership Applications to non-members who attended our Monthly Dinner Meetings.

136

More new members are interested in employment opportunities and job information. Some are interested in the National Chemistry Week, others are interested in Government Relations, Hospitality and other functions. New members are integrated by assigning them specific functions. We try to assist and support our new members and refer them to the appropriate resources.

The committee works very closely with Mrs. Karen Piper, Business Manager of The Nucleus. She supplies the labels for the new members’ roster. Our Editor of The Nucleus, Dr. Michael Filosa, places a short note in the monthly issues of The Nucleus to invite New Members to our monthly meeting and dinner. Our section secretary, Marilou Cashman, in charge the reservation of the monthly dinner-meeting. Mary Burgess, our Hospitality Chair.

A copy of my “welcome letter” to new members is attached.

October 14, 2007

Dear Colleague,

Congratulations on joining the American Chemical Society and its Northeastern Section. Welcome aboard! We intend to make sure your decision to join was a wise one. We also provide you with a broad range of services and opportunities to help you personally and professionally.

I would like to invite you to be a guest of our section at one of our monthly dinner-lecture meetings of your choice. Our dinner-lecture meetings are usually held on the second Thursday of each month (September through May). Social hour is at 5:30 pm. A table of Career Services Aids and literature will be available. Dinner is at 6:30 pm., with a guest speaker to follow. The lectures are on a drop-in basis; reservations are necessary for dinner.

Our next monthly Dinner Meeting is Norris Award on Thursday, November 8, 2007 at Harvard Faculty Club, 21 Quincy St. Cambridge, MA.5:30pmSocialhour,6:15pmDinner.

At 8:00pm James Flack Norris Award Ceremony is at Mallinckrodt Building, Pfizer Lecture Hall, 12 Oxford Street, Cambridge, MA Our Norris Award recipient is Diane M. Bunce, Professor of Chemistry, at the Catholic University of America. Topic: “ Teaching Is More than Lecturing and Learning Is More than Memorizing”

For dinner reservations please contact our section secretary, Marilou Cashman at 1-800-872-2054 or 1-508-653-6329, or E-mail: [email protected], on or before Thursday, November 1st, a week before the Dinner Meeting and let her know that you are a new member. We welcome your participation and look forward to meeting you.

Information about our monthly meetings will be provided through the Nucleus, our monthly publication. Have you received a copy of the Nucleus? If not, please contact the Business Manager of the Nucleus, Karen Piper at 1-978-456-8622 or e- mail: [email protected]

Once again, welcome to ACS and the Northeastern Section!

Sincerely yours, Michaeline F. Chen - Chair, Membership Committee Northeastern Section, ACS e-mail: [email protected] [email protected] Tel: 781-235-5201

137

National Chemistry Week Report - 2007 Christine Jaworek-Lopes, Chair

In preparation for National Chemistry Week 2007, a volunteer preparation day was held at Emmanuel College on Saturday, October 13, 2007. More than 50 individuals attended this event, which allowed volunteers to practice the hands-on activities and demonstrations in advance of the October celebration. A member of the Boston Children’s Museum staff was on hand to choose which activities worked best for her audience.

On Sunday, October 21, 2007, the Northeastern Section of the American Chemical Society sponsored a National Chemistry Week 2007 Kick-Off Event at Museum of Science-Boston (MoS). More than 50 volunteers (from ACS, Boston Latin High School, the Brauner Committee, Emmanuel College, Malden High School, Merck Research Laboratories – Boston, Stonehill College, Suffolk University, Tufts University) ensured that the more than 1000 visitors to the daylong event enjoyed a number of hands-on activities.

Hands-on activities included: isolating iron from Total cereal, making play putty, studying the chemistry of different types of nails, making UV detector bracelets, making marker butterflies, assessing sugar content in cereals and beverages, and learning how mood lipsticks work.

Among the highlights of the day were the two lecture demonstrations, as part of the Phyllis A. Brauner Memorial lectures, presented by Dr. Bassam Shakhashiri, Professor of Chemistry at the University of Wisconsin-Madison. These captivating lectures were enjoyed by children and adults alike. Approximately 300 individuals attended these lectures which were free with admission to the MoS. In addition, Dr. Shakhashiri was presented with a Salute to Excellence Award for his continued involvement with the NESACS NCW events.

On October 22, 2007, a diverse audience of 225 area high school students participated in a daylong program at the Museum of Science-Boston highlighting the variety of careers impacted by chemistry. This program was funded by receipt of a Local Section Innovative Grant, local section funds, and a donation from Merck Research Laboratory – Boston. Each student received free admission to the museum as well as a bag containing a notebook, a pen, the current issue of Chem Matters, the current issue of Celebrating Chemistry, a periodic table of elephants, a nanomole, and a bag of UV-sensitive beads. Each teacher received in addition to the student bags a mug and the ACS pamphlet entitled,” I Know You are a Chemist But What Do You Do?”

The day commenced with the students participating in an interactive a lecture-demonstration given by Dr. Bassam Shakhashiri. The students then had the opportunity to meet and talk at informal conversation stations with the scientists from a variety of organizations. Each scientist brought a hands-on activity or demonstration to encourage conversation. The scientists that participated in this event were:

 Marta Biarnes – a former cosmetic chemist from L’Oreal USA, now a member of the MoS staff  Jennifer Chute – Criminalist, Boston Police Department Crime Lab  Raksmey Derival – Program Manager, Beyond Benign  Pamela Hatchfield –Head of Objects Conservation, Museum of Fine Arts, Boston  Peter Jepson – Materials Scientist, H.C. Starck  Christian Krahforst – Staff Scientist, Massachusetts Bays National Estuary Program  Mimi Leveque – Art Conservator, Peabody Essex Museum  Jacqueline Massua – Forensic Laboratory Technician, Boston Police Department Crime Lab  James Waters – Technical Support, Waters Corporation  Bassam Shakhashiri – Professor of Chemistry, University of Wisconsin-Madison

The students also had the opportunity to participate in two hands-on activities related to nutrition and tour the MoS. Finally, students had the option of interviewing a scientist and submitting the interview to the NCW committee. Four students participated in this.

138

In addition, an NCW event was held at the Boston Children’s on Saturday, October 27, 2007. Approximately 1300 individuals participated in NCW hands-on activities and demonstrations. A particular favorite at the Boston Children’s Museum was making marker butterflies. More than 40 volunteers from Boston Latin High School, Bridgewater State College, Emmanuel College, Gordon College, Merck Research Laboratories- Boston, Simmons College, Suffolk University, and Tufts University were available to assist visitors throughout the day.

Children grades K-12 were able to participate in the national poster competition. Seventeen posters were submitted for the NCW poster competition. These posters were judged by the scientists who participated in the Monday program. The winners from the NESACS were: K-2: Adam Canfield and Jordyn Cooper (joint entry from the Young Scientists Club, Littleton MA); grades 9-12: Marina Kem from Malden High School. Children grades K-12 had the option of participating in a puzzle contest. The puzzle was designed by Dr. Christopher Morse. Upon solving the criss-cross puzzle, the participants learned they needed to write an essay that is fewer than two hundred words, about a Nobel prize winning chemist. Five students participated in the puzzle contest. The winning essay was submitted by Jeffrey Yu. The NCW events were posted in the Nucleus (local section newsletter), as a flyer (at the Connections to Chemistry workshop), on websites (including www.nesacs.org), in the Wellesley Townsman, via email to my NCW teacher list, and on local radio stations.

Merck Research Laboratory-Boston donated $2000 to support NCW events. Also, NESACS received a $3000 Local Section Innovative Grant to defray the cost of the Monday program.

Public Relations 2007

NESACS had no formal public relations committee this year. The NCW and Brauner Committees had substantial public relations outreach to advertise their activities. The Suffolk University student affiliate chapter produced a television show entitled “Bubbles and Beakers” featuring chemical demonstrations.

This year for the first time NESACS NCW was advertised on television. Doris Lewis, chair of the Brauner Committee, was featured on a news broadcast on NewTV (Newton cable television) describing the Brauner Lecture and other NCW activities, and NewTV aired the NCW promotional video numerous times. Shakashiri’s Once Upon a Christmas Cheery in the Lab of Shakhashiri was aired several times during National Chemistry Week, and was so well-received that it continues to be aired regularly. Dr. Lewis and her Suffolk University student affiliate chapter members in emulation of the Shakhashiri lectures produced a chemical demonstration show that has been aired regularly on NewTV. Additionally, Susan Brauner arranged radio advertising on WBUR in conjunction with the NPR Science Friday show.. With the aid of Cathy Brauner the Brauner Lectures were also featured in the Wellesley Townsman.

Respectfully submitted,

Christine H. Jaworek-Lopes NCW Chair

139

Report of National Meeting Planning Committee - Boston 2007 Robert L. Lichter, Chair

The Planning Committee had five primary undertakings:

• Staffing the hospitality booth at the Boston Convention and Exhibition Center (BCEC) • Obtaining and distributing give-aways at the booth • Providing student assistants to work for the ACS Operations Office • Distributing 10,000 copies of the Summer issue of the Nucleus • Arranging for a trumpet player to open the Council meeting

The Committee carried out all its activities by email and occasional telephone calls. No in-person meetings were held.

Hospitality Booth

ACS provided a large booth surrounded on three sides by a counter. While the booth was supposed to be located directly inside the BCEC entrance, in fact it was off to one side. Consequently, ACS at our request made and placed a sign at the entrance directing attendees to the booth. This seemed to have been effective.

Volunteers Through the diligence of Mary Burgess, more than 60 volunteers were identified to staff the booth over the course of the meeting from Saturday afternoon through Thursday morning. Each volunteer received a nametag that Mary had generated, and a T-shirt. However, judging from the number of unused nametags and remaining T-shirts, perhaps half that number

140

actually appeared. This was not a problem because both ACS and the Boston Convention and Visitors Bureau (CVB) provided full-time staff to be at the booth. For future planning (the 2010 meeting), assuming the same conditions apply, the number of volunteers needed could be substantially smaller.

Give-aways After considering a number of possibilities (thanks to Michaeline Chen), we ordered from Cravings Gifts, Topsfield, MA, 1,500 refrigerator magnets depicting the Boston skyline, and 1,500 1-oz boxes of “Boston Baked Beans,” peanuts with a red sugar-coating. Each was imprinted with “Boston ACS Meeting 2007, Northeastern Section.” The items had a high vapor pressure and disappeared within three days. In future, perhaps 2,000 of each might be ordered, but more than that are not recommended.

Cravings Gifts was identified through the Boston CVB. It was selected because it was the most responsive of the four to five vendors who replied to a request for bid, and had the best prices. For future reference, the contact and owner is Heidi Bond, [email protected].

T-shirts. Several committee members explored sources for T-shirts (thanks to Amy Tapper, Doris Lewis, and Don Rickter). In the end, Mike Filosa obtained from Pisano Designs 70 bright yellow T- shirts imprinted with a NESACS logo in front and the inscription, Volunteer/American Chemical Society/National Meeting/Boston/2007 (each component on separate lines) on the back. Thanks are owed to Harvey Steiner for sending the logo to Pisano and to Mary Mahaney for getting the T-shirts to the BCEC. Mike Filosa is storing remaining shirts for further distribution.

Distribution of the Nucleus

Ten thousand copies of the Nucleus were delivered to the hospitality booth for distribution. Through the energetic efforts of Mary Mahaney and Mary Burgess, these were dispersed to multiple locations throughout the BCEC, including a table reserved for the Section at the Expo, and were handed out to individuals as they arrived at the BCEC. Copies were also distributed at every meeting hotel. Some were taken to individual sessions, committee meetings, and social events. However, there is no way of knowing how many were actually picked up. In the end, somewhat more than 1,000 copies remained undistributed, so the actual print run required for the next meeting needs to be revisited. Mike Filosa notes that the content remains useful beyond the meeting, and copies could be distributed in other venues.

Mike also observed that preparing the issue was a demanding undertaking that was facilitated by the contributions of many people. Indeed, the varied content of the issue generated many favorable comments from meeting attendees. Mike invites suggestions from everyone about how to improve the issue for the next ACS meeting. Thanks are owed to Mike for his leadership and to all who submitted copy.

Student Assistants

Amy Kallmerten was able to identify 15 undergraduates and graduate students who were interested in working as student assistants for the ACS Operations Office and submitted their contact information to ACS. They were to be paid $10 an hour. In the event, however, not all the students appeared. Some changed their plans at the last

141

minute, others could not be contacted, and a number indicated that they could work only certain limited hours. The problem was especially acute for covering the evening hours. A last-minute effort was made at the meeting to unearth more students, but the results of that effort are not known. As of this writing, the final outcome has yet to be determined, including whether the ACS office had a sufficient number of student workers.

Note: some confusion existed between the roles of student assistants, who were paid to work for ACS, and volunteers, who were devoting time to the Section’s hospitality booth activities. This occasionally led to people offering to serve as one when they meant the other, and names being directed to the wrong coordinator. This should be made clearer.

Council meeting

Michaeline Chen reminded the committee of the erstwhile custom of opening the Council meeting with a trumpet fanfare played by then-Councilor John Verkade. Suggesting that we try to revive this tradition, Michaeline identified a Boston University music student, Patrick Doyle, who was available to perform, and at a very reasonable rate. The ACS leadership approved this activity and agreed to keep it secret. At the beginning of the Council meeting, Mr. Doyle performed a fanfare of his own composition, which was greeted by enthusiastic applause and cheering. Appropriately, Michaeline was publicly thanked in the Council meeting.

A short time after the end of the ACS meeting, ACS President Katie Hunt sent the following email:

Bob,

I just have to tell you that Patrick and his trumpet fanfare started Council off on a magnificent note!

This is a Council meeting that I will not soon forget! Thank you again for your part and your section's part in "making this so"!

p.s. I do owe you an official THANK YOU but I wanted to get at least an 'unofficial' thank you ....ON THE RECORD!

very best regards, Katie

Many thanks to Michaeline for conceiving of the idea and carrying it out.

Other activities

The Section engaged in, organized, or co-organized a number of other activities that did not come under the purview of the Meeting Planning Committee. These included:

WCC Golf Tournament (Amy Tapper and Harry Mandeville) Reception jointly with the Division of Chemical Education and in honor of the German Exchange Program participants (Mort Hoffman) High school day (Steve Lantos, Ruth Tanner) Several symposia organized by Section members (Pam Mabrouk, Mukund Chorghade)

142

Reports from the principals will presumably be submitted separately.

In addition, the speaker at the Committee on Minority Affairs luncheon was Shanadeen Begay, a graduate student at Boston University and a former ACS Scholar. She gave a very moving talk about her experiences as Native American in a scientific world. That talk would be worth publishing in the Nucleus.

ACS Support

Staff support ACS Meetings Office staff was of great help in the planning efforts. Special thanks go to Peggy Smith and Beverly Johnson at ACS, and Michelle Stevenson and her inadequate number of overworked staff in the ACS Operations Center at the BCEC.

Hotel room ACS provided a complimentary hotel room in the Intercontinental Hotel for relaxation by hospitality booth volunteers.

Financial support ACS reimburses the Section for meeting planning expenses in two forms: a one-time $500 payment that requires no accounting, and a $0.50 per paid registrant reimbursement paid on submission of eligible receipts. The final reimbursement, based on 12,409 paid registrants, was therefore $6,204.50, which was deposited electronically in the Section’s account.

Other

The Committee considered several additional activities but did not pursue them. These included: • A list of restaurants off the beaten track, comprising favorite restaurants of individual NESACS members • Information about Boston entertainment and social activities directed to younger attendees, particularly students. Most information provided by the CVB is intended for adults. Given the large number of younger attendees, such information could have a good market. Perhaps Student Affiliate chapters and YCC could prepare these. • A costumed “greeter” at the BCEC on the first full meeting day. This would have been costly.

Considerations for the future

The experience with the 2007 Boston meeting led to some notions that could be considered for the 2010 meeting. These are embedded in the text above and are rearticulated here, along with a few additional items:

Revisit the number of volunteers actually needed in the hospitality booth in light of the staffing by ACS and the CVB.

Improve the yield of student assistants who eventually report for work. Make the distinction between paid student assistants and Section volunteers clearer.

Optimize the numbers of giveaways purchased with respect to cost vs. expected distribution.

Optimize the print run of the Nucleus. Consider ways to increase the actual reading of the newsletter. Make better use of the NESACS Web site for informing meeting attendees.

143

Consider ways to engage highly accomplished NESACS-region high school students in the national meeting.

Acknowledgments

In addition to the people mentioned explicitly above, thanks are owed to the planning committee and to substantial numbers of anonymous Section members and their friends and family for contributing to the meeting’s success. All credit for accomplishments at the meeting goes to all the named and unnamed participants, and to Marilou Cashman for her continued expertise in NESACS matters. Errors, oversights, and deficiencies are the responsibility of the putative chair of the planning committee.

ACS meeting planning committee: Mary Burgess Michaeline Chen Michael.Filosa Patrick Gordon Mort Hoffman Amy Kallmerten Pam Mabrouk Mary Mahaney Harry.Mandeville John.Podobinski Marietta.Schwartz Amy Tapper National Meeting - Boston 2007

NESACS Receives Three ChemLuminary Awards Section Is Finalist in Six Categories

Christine Jaworek-Lopes receiving ChemLuminary Award from Will Lynch (L) with Dan Eustace, ChemLuminary, and Immediate Ingrid Past Montes (L) and Ann Nalley ( R). Photos by R. Lichter ACS President Ann Nalley ( R)

144 The awards were in the following categories: Outstanding Local Section Younger Chemists Outstanding Local Section Career Program Award from Committee, Outstanding Community Involvement in the Committee on Economic and Professional Affairs; National Chemistry Week, Outstanding Performance by Most Original Hands-on Activity of Chemical a Local section, Very large Size category Demonstration in National Chemistry Week Award from the Committee on Community Affairs; Most Innovative In addition, the address for the 2007 Volunteer Service to New Activity or Program in a Local Section Award from the American Chemical Society Award was given at the the Local Section Activities Committee. ceremony by MortonHoffman, Professor Emeritus at NESACS was also a runner-up for the following awards Boston University, entitled, “The Time of Your Life.”

Morton Z. Hoffman receiving 2007 ACS Award for Volunteer Service from ACS President Katie Hunt. All photos by R. Lichter

German Program at National Meeting Boston 2007

Laila Dafik, NESACS YCC Chair Mike Strem presents an ACS speaking at the German Exchange Salute to Excellence to Dr. Kurt Symposium Begitt, Deputy Director of the GDCh.

145

German Exchange participants with NESACS YCC Chair, Laila Dafik

New Red Sox Fans!!

146

REPORT OF THE NOMINATING COMMITTEE - 2007 Patricia A. Mabrouk, Chair

The Nominating Committee was chaired by Dr. Patricia A. Mabrouk, immediate Past-Chair of the Northeastern Section. The following are the results of the balloting for the 2008 ACS officers of the Northeastern Section. There were a total of 451 ballots counted..

NESACS ELECTION RESULTS - 2007 BALLOT

Name Votes Result Position Term

E. Joseph Billo 405 Elected Chair-Elect 1 year

Michael Singer 405 Elected Secretaryr 2 years

Esther A. H. Hopkins 399 Elected Trustee 3 years

Thomas R. Gilbert 364 Elected Councilor 3 years Pamela M. Nagafuji 328 Elected Councilor 3 years Michael Singer 323 Elected Councilor 3 years Robert L. Lichter 321 Elected Councilor 3 years Timothy B. Frigo 312 Elected Alternate Councilor 3 years. David Cunningham 312 Elected Alternate Councilor 3 years Mark Froimowitz 272 Elected Alternate Councilor 3 years Eriks Rozners 263 Elected Alternate Councilor 3 years Mukund S. Chorghade 259

Stephen Lantos 379 Elected Director-at-Large 3 years

Dorothy J. Phillips 295 Elected Nominating Committee 1 year Jerry P. Jasinski 200 Elected Nominating Committee 1 year David Cunningham 170 Pamela M. Nagafuji 157

Arthur S. Obermayer 234 Elected Esselen Award Comm. 4 years Charles E. Kolb 230 Elected Esselen Award Comm. 4 years Alfred Viola 223 Sean Lu 122

Daniel G. Nocera 246 Elected Richards Medal Comm. 4 years Dagmar Ringe 238 Elected Richards Medal Comm. 4 years Barry L. Krger 223 Peter Jacobi 124

147

NORRIS AWARD COMMITTEE ANNUAL REPORT 2007 J. Donald Smith, Chair

Committee members for 2007 Professor Mort Hoffman, Boston University Professor Mary Jane Shultz, Tufts University Professor Donald Smith, University of Massachusetts Dartmouth, Chair Professor Barry Snider, Brandeis University Professor Jerry Mohrig, Professor Mary Virginia Orna, College of New Rochelle Professor John W. Moore, University of Wisconsin, Editor, Journal of Chemical Education

Committee Charge The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry is presented annually by the Northeastern Section to an educator who is both an excellent classroom teacher and whose professional activities have had a wide-ranging effect on chemical education. The award consists of an honorarium for $3000 and an award certificate.

Committee Activities A total of 8 nominations were considered. All were updated re-submissions of materials received in previous years. Copies of the files were circulated to the committee. A conference call was held by the committee in May 2006. At this virtual meeting the awardee was decided. The 2007 honoree was Professor Diane Bunce of the Catholic University of America.

Barry Snider, who was Assistant Chair in 2007, becomes Chair of the Committee for 2008.

Preliminary notifications of the award were sent to The Nucleus and the Journal of Chemical Education, and appeared in their summer editions.

The Norris Awards Dinner was held in the Theatre Room of the Harvard University Faculty Club on November 8, 2007. The attendance was 78 including a number of Committee Members and previous Norris Awardees. The award presentation and talk took place in the Pfizer Lecture Room of the Harvard Chemistry Department.

A Call for Nomination was written and submitted to The Journal of Chemical Education and the Nucleus. The Norris Award Section of the NESACS Web Site was also updated to include the call for nominations and information on submission. Inquiries about one potential new nominee have already been received for 2008 as have several resubmissions for current nominees.

Respectfully submitted, J. Donald Smith, Chair

148

Norris Award Committee 2007, and Affiliations

Term Expires Dr. Barry Snider 12/31/08 Northeastern Section Dr. J. Donald Smith 12/31/08 Northeastern Section Dr. Mort Hoffman 12/31/10 Northeastern Section Dr. Mary Jane Shultz 12/31/10 Northeastern Section

Dr. Jerry Mohrig 12/31/10 Dr. Mary Virginia Orna 12/31/08 Dr. John W. Moore n.a. ex officio member as editor of JChemEd

Comments Four members of the committee must be from the Northeastern Section, and are elected by the Section. The term is four years. The chair is selected by the committee, and must be from the Northeastern Section. The Editor of the Journal of Chemical Education is an ex officio member of the committee. The remaining two committee members must be ACS members, but not from the Northeastern Section. The term is four years. The committee is responsible for selecting outside members.

Call for Nominations James Flack Norris Award for life in chemistry and/or related sciences, Outstanding Achievement in or may attest to the influence of the nominee’s other activities in chemical the Teaching of Chemistry education, such as textbooks, journal Nominations are invited for the 2008 articles, or other professional James Flack Norris Award for Outstanding activity at the local or national level. Achievement in the Teaching The committee looks for impact of the of Chemistry. The Norris Award, one candidate’s activities at the National of the oldest awards given by a Section and International level. of the American Chemical Society, is The nomination materials should presented annually by the Northeastern consist of a primary nomination letter, Section. The Award consists of a certificate supporting letters, the candidates curriculum and an honorarium of $3,000. vitae. Reprints or other publications Nominees must have served with should NOT be included. Ther special distinction as teachers of chemistry material should not exceed thrity at any level: secondary school, pages. college, and/or graduate school. Since Please direct questions about the 1951, awardees have included eminent content of a nomination to the and less widely-known but equally Chairperson effective teachers at all levels. of the Norris Award Committee. The awardee for 2007 was Professor For 2008 the Committee Chairperson Diane M. Bunce of the Department is Professor Barry Snider, of Chemistry of the Catholic University Department of Chemistry, Brandeis of America University. email: Nominations should focus on the snider(at)Brandeis.edu . candidate’s contributions to and effectiveness Send nomination packets electronically in teaching chemistry. The in Adobe PDF format to Ms. nominee’s curriculum vitae should be Marilou Cashman, Administrative Secretary included. Seconding letters are also an of NESACS. email: important part of a nominating packet. mcash0953(at)aol.com. These may show the impact of the The deadline for nominations is nominee’s teaching in inspiring colleagues April 15, 2008. _ and students toward an active

149

James Flack Norris Awardee for Outstanding Achievement in TeachingChemistry, Professor Diane M. Bunce, Catholic University of America, Washington, DC

150

PROGRAM Harvard Faculty Club Harvard University Cambridge, MA

5:30 P.M. Social Hour 6:15 P.M. Dinner 8:00 P.M. Award Ceremonies

Marietta Schwartz Chair-elect, Northeastern Section, presiding

Presentation of Arno Heyn Memorial Book Award to Myron S. Simon by Vivian Walworth Chair, Board of Publications

James Flack Norris Myron S. Simon Archivist, Northeastern Section, ACS

Introduction of Norris Award Recipient Michael P. Doyle University of Maryland

Presentation of Norris Award J. Donald Smith Chair, Norris Award Committee

Norris Award Address “Teaching Is More than Lecturing and Learning Is More than Memorizing”

Diane M. Bunce Professor of Chemistry The Catholic University of America

151

PRIOR RECIPIENTS OF THE JAMES FLACK NORRIS AWARD FOR OUTSTANDING ACHIEVEMENT IN THE TEACHING OF CHEMISTRY

George Shannon Forbes ...... 1951 John Xan ...... 1953 Harry Nicholls Holmes ...... 1955 Norris Watson Rakestraw ...... 1956 Emma Perry Carr-Mary Lura Sherrill...... Spring, 1957 ...... Fall, 1957 Herman Irving Schlesinger ...... Spring, 1959 Louis Frederick Fieser ...... Fall, 1959 Louis Plack Hammett ...... 1960 ...... 1961 Ralph Lloyd Shriner ...... 1962 Avery Allen Ashdown...... 1963 James Arthur Campbell - Lawrence Edward Strong ...... 1964 Walter John Moore...... 1965 John Arrend Timm - Edgar Bright Wilson...... 1966 Edward Lauth Haenisch...... 1967 Samuel Edward Kamerling - William Campbell Root ...... 1968 Joseph Edward Mayer ...... 1969 Hubert Newcombe Alyea...... 1970 Charles Lester Bickel ...... 1971 Saul Gerald Cohen ...... 1972 Eugene George Rochow ...... 1973 Grant Hopkins Harnest ...... 1974 Leonard Kollender Nash...... 1975 Malcolm Mackenzie Renfrew...... 1976 Anna Jane Harrison ...... 1977 Paul Doughty Bartlett - Henry C. McBay...... 1978 Harry Hall Sisler ...... 1979 Robert C. Brasted...... 1980 ...... 1981 William Thomas Lippincott...... 1982 Bassam Z. Shakhashiri ...... 1983

152

Henry A. Bent...... 1984 Derek A. Davenport ...... 1985 Glenn A. Crosby ...... 1986 Joseph B. Lambert...... 1987 Dana W. Mayo - Ronald M. Pike...... 1988 Jerry R. Mohrig...... 1989 Joseph A. Schwarcz...... 1990 John W. Moore...... 1991 Jerry A. Bell...... 1992 Arthur C. Breyer...... 1993 Samuel P. Massie ...... 1994 Michael P. Doyle...... 1995 Mary Virginia Orna...... 1996 A. Truman Schwartz...... 1997 Angelica M. Stacy...... 1998 Joseph J. Lagowski...... 1999 Billy Joe Evans ...... 2000 Dennis G. Peters...... 2001 Zafra Lerman ...... 2002 David N. Harpp...... 2003 Richard N. Zare...... 2004 Morton Z. Hoffman...... 2005 Brian P. Coppola...... 2006

JAMES FLACK NORRIS: THE MAN AND THE AWARD*

The James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry pays tribute to outstanding contributions to the field of chemical education and in so doing honors the memory of a distinguished teacher of chemistry: James Flack Norris.

The Award The Norris Award is one of the oldest national awards of the American Chemical Society and is presented annually by the Northeastern Section. The recipient is selected from an international list of nominees who have served with special distinction as teachers of chemistry at any level and whose efforts have had a wide-ranging effect on chemical education. The award has been given for a wide variety of achievements: for outstandingly effective textbooks, lecture demonstrations, or laboratory experiments, for editing the Journal of Chemical Education, for developing the Chemical Educational Material Study Project, or for new ways to teach laboratory courses in chemistry. Always, and this is of the utmost importance, the specific achievement must be coupled with dedicated teaching of chemistry at the graduate, undergraduate, or high school level. The award consists of a citation and an honorarium.

The Man James Norris was born in 1871 in Baltimore. He was the fifth of nine children and attended schools in that city and in Washington, D.C. His collegiate career started at Johns Hopkins University, from which

153

he graduated with an A.B. degree, Phi Beta Kappa, in 1892. He was strongly attracted by the great and consequently decided to carry out his graduate studies at Johns Hopkins where he investigated complex compounds of selenium and tellurium. In 1895 he obtained his Ph.D. After graduation, Professor Norris served in the Chemistry Department of M.I.T. In 1904 he then moved to the newly founded Simmons College to become its first Professor of Chemistry and to head its School of Science. He remained at Simmons until 1915 except for 1910-11 when, feeling the need for more physical chemistry, he spent a sabbatical with Fritz Haber at Karlsruhe. After one year at Vanderbilt University, Norris returned to M.I.T. where he remained for the next 24 years as an enthusiastic and successful teacher of chemistry. On February 4, 1902 he was married in Washington, D.C. to Anne Bent Chamberlin, daughter of an Army Captain. They had no children. Professor Norris died in Cambridge, Massachusetts on August 4, 1940.

In 1916 Norris was a member of the Naval Consulting Board and during World War I he served as a Lt. Colonel in the Chemical Warfare Service. After the war, he served for ten years as vice chairman and chairman of the Division of Chemistry and Chemical Technology of the National Research Council.

Although serious when the occasion called for it, the debonair Norris was known as "Sunny Jim" to a host of friends who found him a jovial companion.

His activities in the ACS were many: Chairman of the Northeastern Section in 1904 and President of the National Society in 1925 and 1926. As President of the Society, he did much to improve and clarify the finances of the society. He was also active in the National Research Council and in IUPAC, serving as vice president of the latter from 1925-28. He was an honorary member of the Rumanian Chemical Society and of the Royal Institute of Chemistry in Great Britain. In 1937, he received the gold medal of the American Institute of Chemists for "outstanding service as a teacher and as an investigator." Norris was one of the first chemists to study the structure- reactivity relationship of organic compounds on a systematic basis. Between 1912 and 1922 he authored four influential textbooks in inorganic and organic chemistry. The income from those texts, at least in part, formed the foundation of the bequest from Mrs. Norris to the Northeastern Section in 1948. The purpose of this bequest, to quote the will of Mrs. Norris, is "to keep green the memory of James Flack Norris."

The Norris Fund has grown over the years with judicious management by the Trustees of the Northeastern Section. From its income the Section sponsors two James Flack Norris Awards: the James Flack Norris Award in Physical Organic Chemistry, administered by the National ACS, and the James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry. Tonight's recipient joins a distinguished group of predecessors.

*Taken from the biographical memoir of James Flack Norris by John D. Roberts and from the biography of James Flack Norris given by Joseph Bornstein at the presentation of the James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry.

154

NORTHEASTERN SECTION

of the

AMERICAN CHEMICAL SOCIETY

Presentation of the Fifty-sixth

JAMES FLACK NORRIS AWARD

for

Outstanding Achievement in the Teaching of Chemistry

to

PROFESSOR DIANE M. BUNCE

Thursday, November eighth Two thousand seven

Harvard Faculty Club Harvard University Cambridge, MA

155

The Northeastern Section of the American Chemical Society confers the fifty-forth

James Flack Norris Award for Outstanding Achievement in the Teaching of Chemistry on Diane M. Bunce Catholic University of America – Washington, D.C.

In recognition of a career exemplifying excellence in chemical education

You are honored for your contributions to understanding student learning, effective assessment, and communication of chemistry. Your passion for chemistry and education manifests itself in the classroom, as advisor and mentor, in your writing, in interactions with colleagues at many levels, and in your public service. Your knowledge and infectious enthusiasm for chemistry and your extraordinary ability to communicate this to others have generated a host of intellectually excited students and teachers. You have notably enriched the heritage and future of chemical education.

J. Donald Smith November 8, 2007 Mukund Chorkade Chair, Norris Award Committee Chair, Northeastern Section

156

REPORT OF THE PROFESSIONAL RELATIONS COMMITTEE - 2007 Submitted by Mukund S. Chorghade

The NESACS Professional Career Services Committee is dedicated to providing ACS Members with the best and latest tools to manage careers: we offer career guidance and focus on the components of targeting the job market, personal assessment, identifying market trends, credentials, research and networking. We have a comprehensive (lecture, demo and review) program that provides assistance in writing winning resumes and cover letters, learning various techniques and skills needed for a successful job interview and negotiating an attractive job offer.

Mukund Chorghade, as Chair of this committee attended both National Meetings and actively participated in the work of the ACS Department of Career Services and Professional Development in reviewing resumes and conducting mock interviews. Dr. Daniel Eustace has been a most welcome and effective contributor to these. Special accolades are due to him for helping in redesigning and participating in several innovative ACS presentations and personally leading highly and superbly interactive and novel workshops on interviewing, career development etc. There has been considerable audience participation from employers and interviewees. Both Dan Eustace and Mukund Chorghade have been selected to participate in the ACS National “Train the Trainer’s Program”

Dan Eustace also presented at the afternoon Career Services Employment Seminars that were held preceding the regular meeting of the Northeastern Section. We introduced this as a regular feature in all the monthly meetings (January-June). Typically, a lecture on resume presentations was presented and publications of the ACS National Employment Services were distributed. These publications were also distributed at each of the monthly meetings in the evening. Also, at the monthly meetings assistance with employment was available. This year as an innovative attempt to network employment-seekers with professional recruiters, we co-opted two highly respected industry professionals Megan Driscoll and Jennifer Sass, Pharmalogics recruiting, to our team. These two reviewed resumes and provided guidance on careers. As an added bonus, they assisted some job-seekers get interviews and eventually placements within the pharmaceutical and biotech industries even in locations such as Kansas. Mukund also presented workshops at the Mass College of Pharmacy, University of Wisconsin, Madison, and University of Toledo. Requests have now come in from India and from the Royal Society of Chemistry to do so in London

I am also grateful to the Northeastern YCC for organizing a highly successful Career Fair For their innovative efforts with such large attendance and benefits to local area members. The YCC has been an extraordinarily active and proficient group; the officers and membership have to be complimented for their innovative contributions.

We assisted in planning the annual October Professional Relations meeting which included presentations of 50-year pins and the Henry Hill Award for Outstanding Local Services. In August, our distinguished members, Ted and Arlene Light, who have rendered such yeomen service to our section, were honored with the Henry Hill Award. A special symposium honoring Ted and Arlene Light was organized. Distinguished speakers included John Sophos (from the ACS), James Burke and Dan Eustace The program was described as a “love fest” by one speaker: the outpouring of love, affection and admiration for Ted and Arlene was worth going miles to see. I felt honored to organize a symposium in their honor. It was also a singular pleasure to participate in the many ceremonial events during the meeting.

157

Mukund Chorghade was privileged to join the Division of Professional Relations (PROF) Three standing symposia have been added: these will be presented in conjunction with CEPA, IUPAC and Department of Career Services at all future National meetings

1) What does it take to succeed in the pharmaceutical / biopharmaceutical industry?"

The pharmaceutical sector has traditionally been a vibrant, innovation-driven and highly successful component of industry at large. In recent years, a confluence of spectacular advances in chemistry, molecular biology, genomic and chemical technology and the cognate fields of spectroscopy, chromatography and crystallography have led to the discovery and development of numerous novel therapeutic agents for the treatment of a wide spectrum of diseases. In order to facilitate this process, there has been a significant and noticeable effort aimed at improving the integration of discovery technologies, chemical outsourcing for route selection / delivery of active pharmaceutical ingredients, drug product formulations, clinical trials and refined deployment of information technologies. Multi-disciplinary and multi-functional teams focusing on lead generation and optimization have replaced the traditional, specialized research groups. To develop a drug from conception to commercialization, the biotechnology / biopharmaceutical industry (which has been highly entrepreneurial) has reached out and established global strategic partnerships with numerous companies.

Four distinguished speakers from the pharmaceutical / biopharmaceutical industries will explain how the work has changed and how project conception and management has evolved over the past 20 years. They will explain how the innovation process / management of projects and the progress from conception to commercialization has changed over the years

2) "Careers in Chemistry-Are there alternatives to working at a laboratory bench?"

Several professionals who have made a successful transition from bench chemistry to alternate professional work in which their own training in Chemistry has been of inestimable value will enlighten audiences about the satisfying and stimulating aspects of their career choices and careers.

3) To Ph. D. or not to Ph. D-A guide to the perplexed student

Experts will discuss job prospects and career success for chemists at various degree levels and various professional levels.

In general our members have provided positive feedback. Reproduced below are comments from one of our members who benefited from our programs:

“My career counseling session with Dr. Chorghade began with some basic questions designed to engage me and focus me on clearly stating my objectives. The process of reviewing my CV began with an examination of its overall structure and an assessment of the impression of prospective screeners. This overview was followed by a detailed review focused on content, wording and vocabulary. I have read several books on resume writing and attended many workshops. The assistance that I received through ACS career services has been the most knowledgeable and helpful that I have experienced. While the improvements to my CV are significant, the feedback I received on my qualifications and search strategies were profound. The best part of the process is the quality of assistance and sincere caring of the counselor.”

158

Professional Relations Sass of PharmaLogics Recruiting, will join me in offering valuable perspectives and 1:1 career counseling to NESACS members. These sessions will typically be held between 2:30 pm and 4:30 pm. Members will be able to benefit from Career such networking: this will be a regular feature of Section Meetings in 2007. In general our members have provided Services at positive feedback. Reproduced below are comments from one member who benefited from our programs: Monthly “My career counseling session with Dr. Chorghade began with some basic questions designed to engage me and Meetings focus me on clearly stating my objectives. The NESACS Career Services Committee The process of reviewing my CV is dedicated to providing ACS began with an examination of its overall Members with the best tools to manage structure and an assessment of the careers. We offer career guidance and impression of prospective screeners. focus on the components needed for This overview was followed by a targeting the job market: personal detailed review focused on content, assessment, identifying market trends, wording and vocabulary. I have read credentials, research and networking. several books on resume writing and We have a comprehensive (lecture, attended many workshops. The assistance demo and review) program that provides that I received through ACS assistance in writing winning career services has been the most resumes and cover letters as well as knowledgeable and helpful that I have various techniques and skills needed experienced. While the improvements for a successful interview. to my CV are significant, the feedback In collaboration with the Speaker’s I received on my qualifications and Bureau, we will organize a program of search strategies was profound. The resume reviews and short lectures best part of the process is the quality of focusing on current topics at Section assistance and sincere caring of the Meetings. Two distinguished recruiters counselor.” in our area, Megan Driscoll and Jennifer

from industry professionals. Topics and services which we will Career cover: how to put together an eyecatching resume, best interviewing strategies, and how to find the most Services appropriate opportunities Are you interested in changing jobs? Do you wonder whether your interviewing abilities could be enhanced? Could your resume use some work? If yes, please join us at the January meeting, where you can receive advice

159

Ted and Arlene Light Presented at the ACS Henry Hill Award, Tuesday, August 21, 2007

REPORT OF THE CHAIR–ELECT / PROGRAMS - 2007 Mukund Cborghade

As Program Chair, the Chair–Elect organized those monthly meetings of the Section (speakers, venues, etc.) that were not otherwise within the purview of the special awards committees (Esselen Award, Norris Award) and the Medicinal Chemistry Group.

Date Program

January 18 Monthly Meeting - Harvard Faculty Club Joint meeting with Boston Area Group for Informatics and Modeling (BAGIM) Dr. Yvonne Connolly Martin, Sr. Research Fellow (retired), Volwiler Societty. Abbott Laboratories Topic: Lessons from 41 Years as a Computational Chemist February 8 Monthly Meeting – Harvard Faculty Club, Cambridge, MA Jeannette Elizabeth Brown, Educational Consultant Topic: African-American Women Chemists Who Made a Difference March 8 Monthly Meeting - University of Massachusetts Boston Prof. Michael R. Wasielewski, Northwestern University (Recipient of ACS Norris Organic Chemistry Award) Topic: Charge and Spin Transport Dynamics in Bio-inspired Molecules: From Photosynthesis to Organic Electronics April 12 Monthly Meeting - Harvard University Gustavus John Esselen Award Dr. Michael A. Marletta, University of California, Berkeley Topic: Nitric Oxide in Biology: From Discovery to Therapeutics May 10 Monthly Meetng / Education Awards - Northeastern University Dr, Steve Jones, Sepracor, Inc. Topic: The Interplay of Chemistry and Biology Presentation of Awards: Philip L. Levins Memorial Prize Norris/Richards Undergraduate Research Fellowships Undergraduate Grants-in-Aid Project SEED Certificates Richards Secondary Teaching Awards Aula Laudis Society - Induction of Members Ashdown Examination Prizes Simmons College Prize Phyllis A. Brauner Memorial Book Award

May 17 Medicinal Chemistry Symposium Topic: Lead Optimization Strategies

160

Speakers: Norton Peet, International Consultant, No. Andover, MA Introductory Remarks Prof. L.V.G. Nargund, Nargund Research Foundation Nargund College of Pharmacy, Bangalore, India, Green Chenistry: Synthesis of Small Molecules by Microwave Technique Neal Green, Wyeth Research, Cambridge, MA Inhibitors of Tp12 Kinase and TNF Production: Selectivity and In Vivo Anti- inflammatory Activity of Novel 8-Substituted-4-anilino-6-aminoquinoline-3-carbonitriles Mark T. Goulet, Merck Research Laboratories, Boston, MA Lead Optimization of Orally Bioavailable Drugs Horst Hemmerle, Discovery Chemistry, Eli Lilly and Co., Indianapolis, IN Use of Rllevant Chenical Diversity in Drug Discovery September 20 Monthly Meeting – Joint meeting with Medicinal Chemistry Group Medicinal Chemistry Group Symposium – Holiday Inn Select Hotel, Woburn, MA Topic: Building Bridges between the Pharmaceutical Industry and Academia -- A New Paradigm for Drug Discovery Moderator: Dr. Tom Large, VP-Drug Discovery, Sepracor, Inc. Speakers : David Weaver, Director, New Leads Discovery, Vanderbilt University New Frontiers in Exploratory and Early Drug Discovery Research: A Hybrid Academic/Industrial Approach Greg Cuny, Director, Laboratory for Drug Discovery in Neurodegeneration, Harvard Medical School Opportunities and Challenges for Medicinal Chemistry in Academic Drug Discovery Perry F. Renshaw, M.D., McLean Hospital Brain Imaging Center, Harvard University In Vivo Magnetic Resonance Spectroscopy in Drug Discovery and Development Iwao Ojima, Professor & Director, Institute of Chemical Biology & Drug Discovery, SUNY at Stony Brook Opportunities for Translational Research in Chemical Biology and Drug Discovery October 18 Monthly Meeting – University of Massachusetts Boston Henry A. Hill Award for Outstanding Service to the Northeastern Section to Dr. Ruth Tanner 50-Year Members of ACS presented certificates of recognition Dr. Mukund S. Chorghade, President, Chorghade Enterprises / THINQ Pharma Topic: Progression of a Drug from Test Tube to Clinic: A Personal Adventure November 8 Monthly Meeting / Harvard University James Flack Norris Award Dinner & Program Prof. Diane M. Bunce, The Catholic University of America, Award Recipient and Speaker Topic: “Teaching Is More than Lecturing and Learning Is More than Memorizing” December 12 Monthly Meeting – Joint meeting with Medicinal Chemistry Group Medicinal Chemistry Group Symposium – Holiday Inn Select Hotel, Woburn, MA Topic: Signal Transduction Targets and Drug Discovery Moderator: Dr. Norton Peet, International Consultant, No. Andover, MA Speakers: Hariprasad Vankayalapati, Director of Medicinal Chemistry, SuperGen, Inc., Salt Lake City, UT Discovery of MP-529: A Selective Inhibitor of Aurora 2 Kinase in Development for the Treatment of Cancer Adrian D. Hobson, Group Leader, Hit-to-Lead Medicinal Chemistry, Abbott Bioresearch Ctr., Worcester, MA Applications of Parallel Synthesis in Hit-to-Lead Vinod F. Patel, Director of Medicinal Chemistry, Amgen, Inc., Cambridge, MA The Discovery of Motesanib (AMG 706), a Multi-Kinase Angiogensis Inhibitor for Treatment of Human Cancers: From Crystal to Clinic Tomi Sawyer, Chief Scientific Officer & Sr. VP of Drug Discovery, Aileron Therapeutics, Cambridge, MA Exploring Chemical Space in Protein-Protein Interaction Drug Discovery: Bridging Nature to Breakthrough Medicines

161

Photos from Sample Monthly Meetings

The 2007 Henry A. Hill Award will be 2007 Henry A. Hill Award presented at the October meeting to Dr. To Ruth Tanner Ruth Tanner, Professor Emeritus at UMASS Lowell. The Hill Award is presented annually to a member of the Northeastern Section of ACS for meritorious service to the NESACS and to the profession of Chemistry.

162

BOARD OF PUBLICATIONS REPORT FOR 2007 Vivian K. Walworth, Chair

The Board of Publications (BOP) is responsible for oversight and management of both the Nucleus and the NESACS website. The Chair of the BOP also serves as the Chair of the Arno Heyn Memorial Committee.

The Board of Publications of the Northeastern Section of the American Chemical Society (NESACS) for the year 2007 comprised voting members Vivian Walworth, Chair; Mary Mahaney, Secretary, and David Cunningham, who was appointed to the BOP in February by NESACS Chair Mukund Chorghade. Non- voting BOP meeting participants included Nucleus Editor Mike Filosa, Associate Nucleus Editor Myron Simon; Advertising Manager Vince Gale, and Business Manager Karen Piper. During 2007 we instituted a conference call plan, whereby NESACS members not present at meetings could call in during BOP meetings.

In early spring, David Cunningham, who had served on the website team in 2006, agreed to replace Sathish Rangarajan as NESACS webmaster. In February the NESACS Board of Directors voted to provide $3500. for professional services to the website. We subsequently engaged Roy Hagan as website consultant. The two are an effective team. Our 2008 budget includes continued funding for consultant services.

As of January 1, 2008, Mary Mahaney will become BOP Chair and David Cunningham will serve as Secretary. Vivian will continue as a member of the BOP. Vince Gale will continue as Advertising Manager and Karen Piper as Business Manager of The Nucleus. David Cunningham will continue to serve as the NESACS webmaster.

163

In June we asked the Board of Directors to consider adding two more voting members to the BOP. This action would require a Bylaws change, and we referred the matter to the Bylaws Committee Chair, Cathy Costello.

Myron Simon, who has served for many years as an outstanding Associate Editor of the Nucleus, was given the Arno Heyn Memorial Book Prize, a book he had specified as his choice. Inside the book we had affixed a NESACS commemorative bookplate. The presentation took place at the November NESACS meeting. Arno Heyn’s son Robert and his wife, Janice, attended that meeting as guests of the Section.

The following sections of this report comprise detailed material provided by Nucleus Editor Mike Filosa and Webmaster David Cunningham.

(Mike Filosa) The Nucleus published 208 pages in 2007. This was up from 192 in 2006. The major reason for the increase in pages was the publication of a 40-page Summer Edition for the National ACS Meeting’ which was held in Boston in August. An extra 10,000 copies were printed and distributed at the meeting.

Advertising revenues ended a steady decline and increased significantly in 2007, which helped the Nucleus finish the year under budget by $3000. Business Manager Karen Piper and Advertising Manager Vince Gale continued to provide sound financial planning support.

The high point of the year was the Summer Edition, which featured a wide range of articles, including "Getting Ahead" by Megan Driscoll of Pharmalogics Recruiting, an account by Anne McNeil, an MIT postdoctoral fellow, about the trials and tribulations encountered while seeking her first academic position, and an article by a Suffolk University student, Karla Schallies, "Why I Love Organic Chemistry."

Morton Hoffman, James Phillips, and Bob Lichter each submitted a variety of excellent photos to the Nucleus throughout the year, greatly enhancing both the appearance and the interest level of the Nucleus. The editorial team included Associate Editors Sheila Rodman, Nancy Simons and Myke Simon. Sheila coordinated the Calendar. Morton Hoffman and Dennis Sardella continued to make significant contributions as feature editors. Proofreading was performed by Vivian Walworth, Myke Simon, and Don Rickter. Harvey Steiner continued to serve well by putting content into final form for printing. Bob Kuchniki of Saltus Press continued as our main contact at Saltus for proofing the Nucleus, printing and mailing. With their professional support we published the Nucleus and mailed it to our readers on time each month.

(David Cunningham) David and our web consultant, Roy Hagan, worked diligently to revamp the web site and bring it up to date prior to the 2007 ACS National Meeting in Boston. The web site was completely redesigned to current standards a month before the meeting, and it has been kept up to date since that time. Typically, new information has been posted on the day that it was received by the webmaster.

An analysis of site usage shows that the most popular files viewed / downloaded are the Nucleus, followed closely by annual reports, the Ashdown exams, Career Opportunities and Awards.

New and archived issues of the Nucleus were downloaded and viewed a median of 704 times per issue during 2007. Interestingly, archived issues were as popular as current issues. Ranked among the 18 most downloaded issues, the October issues were 2.5 times more likely to be viewed than by equal chance, followed by the March, May and September issues (1.5 times more than equal chance). The single most

164

popular issue was October, 2002, with 3491 downloads, and the most popular 2007 issue was the February one, with 1046 downloads. It appears that archived issues continue to be of interest, giving newer issues relatively fewer downloads than more current issues due to their shorted posting durations. The popularity of the Nucleus on the web, particularly older archived editions, needs to be considered carefully with respect to advertising and content.

The future of our web presence will include continued growth into new technologies, such as podcasts, video and audio streaming, and efforts to integrate more section members into meetings and activities.

165

November meeting Heyn Book Prize

REPORT OF THE 2008 RICHARDS MEDAL AWARD COMMITTEE Gary R. Weisman, Chair

The 2008 Richards Medal will be presented to Professor Robert G. Bergman at the March 13, 2008 meeting of the Northeastern Section of the American Chemical Society (NES/ACS). Professor Bergman is the Gerald E. K. Branch Distinguished Professor at UC Berkeley and a member of the Chemical Sciences Division, Lawrence Berkeley National Laboratory. A reception and banquet honoring the awardee will be held at the Harvard Faculty Club. The award presentation will take place at the Pfizer Lecture Hall at Harvard University followed by the award address titled “Selective Organic and Organometallic Transformations Mediated by Molecular and Supramolecular Environments.”

The Richards Medal Committee consists of members elected by the Northeastern Section, plus the editor of the Journal of the American Chemical Society (JACS) and two ACS members from outside the Northeastern Section selected by the Richards Medal Committee Chair. The committee selecting the 2008 medalist consisted of elected NES/ACS members Prof. Gary R. Weisman of the University of New Hampshire (Chair), Prof. Paul Davidovits of Boston College, Prof. Roy G. Gordon of Harvard University, Prof. Stephen J. Lippard of the Massachusetts Institute of Technology, Prof. Daniel G. Nocera of the Massachusetts Institute of Technology, Prof. Dagmar Ringe of Brandeis University, ACS members Prof. Brian P. Coppola of the University of Michigan and Prof. Mary J. Wirth of the University of Arizona, and Prof. Peter Stang of the University of Utah (JACS Editor).

Profs. Davidovits, Gordon, Nocera, and Ringe are the continuing NES/ACS members of the Committee. Prof Gordon has agreed to serve as Chair through the 2010 Richards Medal award cycle.

166

NORTHEASTERN SECTION AMERICAN CHEMICAL SOCIETY RICHARDS MEDAL AWARD COMMITTEE GARY R. WEISMAN, CHAIR

DEPARTMENT OF CHEMISTRY UNIVERSITY OF NEW HAMPSHIRE DURHAM, NH 03824-3598 TEL: 603-862-2304 EMAIL: [email protected]

PRESS RELEASE NORTHEASTERN SECTION OF THE AMERICAN CHEMICAL SOCIETY

January 10, 2008

ROBERT G. BERGMAN SELECTED 2008 RICHARDS MEDALIST

Professor Robert G. Bergman of the Department of Chemistry of the University of California at Berkeley has been selected to receive the 2008 Richards Medal by the Northeastern Section of the American Chemical Society (ACS). The Richards Medal is awarded every two years for conspicuous achievement in chemistry. It is the section’s oldest and most prestigious award, honoring the first U.S. Nobel laureate in Chemistry.

Robert Bergman is the Gerald E. K. Branch Distinguished Professor at UC Berkeley and a member of the Chemical Sciences Division, Lawrence Berkeley National Laboratory. He spent the first part of his career investigating the mechanisms of organic reactions and the generation and study of unusually reactive molecules. In the mid-1970's his research broadened to include . He has made contributions to the synthesis and chemistry of several types of organotransition metal complexes and to improving our understanding of the mechanisms of their reactions. Most recently he has been involved in the application of C-H activation reactions to problems in organic synthesis. He has previously received the ACS Award in Organometallic Chemistry (1986), an ACS Arthur C. Cope Scholar Award (1987), the ACS Arthur C. Cope Award (1996), and the ACS James Flack Norris Award in Physical Organic Chemistry (2003).

He has been honored with numerous other awards and is an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences (both in 1984). In 2007 he was chosen by the National Academy of Sciences to receive the NAS Award in Chemical Sciences.

After completing his undergraduate studies in chemistry at Carleton College in 1963, he received his Ph.D. at the University of Wisconsin in 1966. After a postdoctoral fellowship at Columbia University, he joined the faculty of the California Institute of Technology, rising through the professorial ranks before moving his research group to UC Berkeley in 1978.

Prof. Bergman will be honored at an award dinner and medal presentation in conjunction with the NESACS meeting scheduled for March 13, 2008 at Harvard University. He will present an award address titled “Selective Organic and Organometallic Transformations Mediated by Molecular and Supramolecular Environments.”

167

168

Report of the SPEAKERS BUREAU Committee - 2007 Mukund S. Chorghade, Chair

As discussed, we embarked on a mission to revitalize the speaker’s bureau. We assembled the best talent in our section and have got a list of refined presentations of broad general interest. We have circulated this list to many schools and community organizations.

A major event that we organized was a “Science-Café” in collaboration with Professor Kathi Browne of Natick High School: we organized this two-hour “in-house field trip for 150 of the best students at Natick High and also for some faculty colleagues.

The program, on October 26 was as follows:

1) Kathi Browne: General introduction 2) Steve Lantos: Ashdown and other scholarship exams, Chemistry Olympiad 3) Mukund Chorghade: The use of chemistry, setting up a Science Club 4) Dan Eustace: Show and Tells regarding the excitement of chemistry and Science 5) John Amedio: Careers, internships etc

Based on the feedback received, the speakers were well appreciated. Students are interested in internships and hearing about additional career opportunities in science. Some have also expressed an interest in joining a science club and in taking part in the various science competitions. Two of the biology teachers present at the assembly asked about the possibility of arranging another assembly where we bring in speakers from the biotech industry. We were able to organize this second event and have Dr. David Pizzi, Sr. Director, Shire Therapeutics and his colleagues visit the school for individual classroom discussions and Q & A.

A delightful spin-off of this event was the organization of a Science Club at Natick High School. for helping the students of NHS in promoting the study of science. Kathy Brown of Natick High School was successful in securing a grant to obtain materials to organize a science club, the goal being to encourage students to participate in and compete in local science competitions such as the Science Bowl and the Women in Science Competition. Our local section helped organize this and provided adult support. The school now has a time and location where students can compete in a friendly sort of way and learn additional science concepts as they do.

We were able to help Amrita Karambelkar secure an internship at Tufts Medical School. She was very excited about this, did a project and is now a co-author of a published paper. She was the first high school senior (accepted at Harvard and MIT) to write a special article for the Nucleus (copied below):

My Research Experience

I peered down at my sample of bacteria calmly sitting in the ice bath. Examining the small test tubes, I measured out exact proportions of DNA solutions with a microliter pipette. Lab was one of my favorite activities in my AP classes; I always wanted a front row seat. At times, I remember being disappointed when working on labs with the whole class and everyone could not actively participate. I enjoyed immersing myself in the numerous handouts and calculations for assignments ranging from bacteria transformation to gel electrophoresis. My passion for science and research led me to look for a summer internship during the summer before my senior year of high school.

I secured a volunteer internship in Professor Athan Kouliopoulos group at the Tufts-NEMC MORI laboratory in Boston for six weeks in the summer of 2006. This was an invaluable experience because my previous knowledge of working in a lab setting was rudimentary. I was soon taught basic procedures, such as labeling tools correctly and autoclaving instruments. I learned several new protocols through my work which will help me in the future,

169

particularly in college lab work. In addition, I had the opportunity to work with sophisticated instruments which I had never seen before, including a massive centrifuge and spectrophotometer. I had the chance to work under a hood, culturing and splitting cell plates. My lab experience enabled me to learn by osmosis through my surroundings.

The work I did at the MORI lab was part of a large effort by many researchers to develop a new method to combat cancer. My two supervisors at the lab, who guided me in my work, told me that the lab hoped to create a lentivirus vector carrying anti-cancer genes that could provide a new way of fighting the disease. My tasks included incorporating the genes into E. coli DNA, or plasmids, and retrieving the plasmids for use in a lentiviral vector. In the process, the plasmids were replicated in the bacteria, grown in culture for days, and purified. I performed several tests, such as gel electrophoresis, to confirm that the correct genes were incorporated in the plasmids. Researchers hope that, in the future, the lentivirus, with the anti-cancer genes, could be injected into a patient with cancer and cure the disease.

My volunteer work in the lab taught me a few important lessons. First, I learned that scientific research of any kind is a slow process, requiring careful observation and patience. I sometimes had to allow hours to pass for culture to grow. Also, I quickly realized that obtaining perfect results was nearly impossible; I dealt with failure in some of my tests. Through the process of failure and correction, I learned how to troubleshoot. I understood that science is not a string of successes, but often a hit-or-miss process, and I would sometimes cross my fingers to see whether a certain experiment had worked. From a scientific standpoint, I learned that chemistry was especially important to the understanding of basic biology. Thus, my research work was valuable not only in enhancing my knowledge of biology and cancer, but also in teaching me basic procedures of lab work and the scientific process.

I will be attending MIT this fall and hope to continue work in all fields of science. My work at the lab only made me more enthusiastic about research, and I hope to do internships in college. I am interested in the biomedical and biochemical fields at MIT, and I am optimistic about my academic dreams for the future.

170

171

The Speakers Bureau - American Chemical Society, Northeastern Section

Speaks up and Speak Out!!

What is the Speakers Bureau?

The Speakers Bureau of the American Chemical Society, Northeastern Section acts as a bridge between the public and science. We are a group of qualified volunteer speakers who have in depth knowledge in chemistry and related sciences and are passionate about sharing our profession with the public. We use intrigue, analogies and humor to inform the public about new strides in sciences, build awareness of science and confront the misconceptions about our profession with knowledgeable answers.

How does our volunteer, free-of-charge program work?

Step 1. We find out what the public wants to know by communicating with various organizations such as museums, schools, and neighborhood groups. Step 2. We set up speaking events through these public venues at no charge to your organization or your audience. Step 3. One of our knowledgeable speakers presents a scientific topic of interest and engages in a healthy discussion.

Call us if :

YOU ARE CONSIDERING having a speaker to engage your group in a lively and healthy discussion on a scientific topic of current interest.

YOU ARE knowledgeable in chemistry or related sciences and passionate about sharing your valuable knowledge with curious audiences

Contact:

Jin Ji, PhD Chairperson, The Speakers Bureau American Chemistry Society, Northeastern Section [email protected]

\

172

From the Nucleus Contact Jin Ji, Ph.D., Chair of the Speaker’s Bureau, at jin(at)jinji.us for Speak Up & more information. U

Speak Out The Northeastern Section of the American Chemical Society (NESACS) is looking for good speakers. In a new effort to build awareness about the benefits of Chemistry in our schools, towns and other industries we are seeking willing and able speakers. The James Flack Norris Speaker’s Bureau of the NESACS is in the midst of a recruitment drive. Qualified volunteers will be asked to appear in front of audiences around the New England area and present a wide variety of subjects ranging from bioterrorism to bubble gum – whatever your area of knowledge may be.

We’ll help you sharpen your presentation skills and assist in setting up speaking appointments. You choose the speaking frequency and location.

173

REPORT OF THE SUMMERTHING COMMITTEE - 2007 Doris I. Lewis, Chair

174

REPORT OF THE TREASURER AND AUDITOR - 2007 James U. Piper, Treasurer

Page 1 of the financial report reflects the transactions in the operating account of the Section. In addition to the operating account, the Trust Funds operate under the supervision of the Board of Trustees. The operating account generally pays all bills and then requests reimbursement of Trust-related expenses from the Trustees. In 2007, those reimbursements totaled $99,672.99 (line 10). Since the Trust funds are separately maintained, the calculation of the Public Support ratio on page 2 of the Financial Report is incorrect. The correct calculation is on the attachment to the Financial Report that is not included in SOLAR.

The Section operating account ran an operating surplus in 2007 only because of the large draw on the Trust Funds. At the end of 2006, $44,149 was owed to the Operating Account by the Trust accounts for expenses incurred during the year. At the end of 2007 the amount due had decreased to $16,779.

A separate set of books is kept for the Nucleus, and these are maintained on an accrual basis. The financial results presented by the Board of Publications differ from those in the Treasurer’s report because the latter is presented on a cash basis. On an accrual basis, the Nucleus had advertising revenue of $52,938 and expenses of $72,120. The deficiency is funded by Section general funds, the Publications Trust and the Norris Trust.

The Attorney General of the Commonwealth of Massachusetts requires nonprofit organizations to file annual reports accompanied, in our case, by a review by a CPA. The review of the 2006 financial statements was completed in August, and the report was filed. Copies of forms 990 and 990T for 2006 were sent to the National ACS office.

James U. Piper Treasurer

175

176

REPORT OF THE BOARD OF TRUSTEES - 2007 Esther A. H. Hopkins, Joseph A. Lima, Michael E. Strem

The Trustees of the Section for the year 2007 were Esther A. H. Hopkins, Michael Strem and Joseph Lima. We met with our financial consultant, Robert M. Sarly, Senior Vice President at Smith Barney, Inc., held informal meetings, received reports from Smith Barney and from Piper Enterprises and discussed recommendations for the Board as to uses for the Funds in our care in keeping with the wishes of the donors of the funds.

The Trust Funds of the Northeastern Section are in three Trust Accounts and six income accounts. The Trust Accounts are (one)—the Consolidated, comprising the principal amounts of the Richards, the Norris, the Publication, the Permanent, the Hill and a portion of the Brauner trusts, (two)—the Esselen Trust, and (three)—the Levins Trust. To keep the capital ratios constant in the Consolidated Trust, capital amounts withdrawn from it are distributed to the Income accounts in the ratio of their ownership.

The Consolidated Account for 2007 had an opening portfolio value of $1,978,325.10. During the year, the account was divided into three parts, one of which became an actively managed account, the second a comparable Trustee-managed account, with the remainder of the assets in the parent account. It was believed that active management would protect the assets from any drastic drop in the markets. Withdrawals from the Consolidated Account made over the year totaled $107,204.94. The adjusted opening balance was, therefore, $1,871,120.16. The closing balance was $2,039,626.68 for an increase of $168,506.52. This represents a gain of 9%. The Consolidated Trust contains money funds, common stocks, closed end funds, mutual funds, and corporate bonds. The current yield at year-end was 4.48% and the annualized anticipated income was $86,137.64.

The Esselen Fund, comprising money funds, mutual funds and government bonds, had an opening balance of $501,578.31. $17,940.58 was withdrawn for the expense of the award this year. The adjusted opening value was $483,637.81 and the closing value was $536,662.13. The Levins Fund, comprising money funds, closed end funds, and mutual funds had an opening portfolio balance of $10,704.78. Expenses of $640 were withdrawn during the year giving an adjusted opening balance of 10,064.78. The closing portfolio value was $11,066.81. The Brauner Trust “income account” comprised of money funds, common stock and closed end funds had an opening balance of $26,328.32. $200 of gifts and $2077.10 of distributions were deposited to the Fund and $2,000 was withdrawn for the previous year’s lectures, giving an adjusted opening balance of $22,605.42. The closing value was $27,617.97 of which $5204.99 was income and the remainder was Trust principal.

The Hill income account comprising money funds and closed end funds had an opening portfolio value of $15,015.67, received $4,994.10 from the prorated distribution from the Consolidated Account and distributed $2,441.89 to the Section for expenses, for an adjusted value of $17,567.88. The closing value was $18,969.64. The Norris Award income account, comprising only money funds had an opening portfolio value of $4,431.68 and an adjusted value of $1,662.86 after receiving 58,339.40 from the prorated distribution and withdrawing $61,209.22 for expenses. The closing portfolio value was $1,847.94. The Permanent income account, comprising money funds, common stocks and closed end funds had an opening portfolio value of $56,088.65, received $14,443.30 from the prorated distribution and withdrew $12,809.65 in expenses for an adjusted value of $57,722.30. The closing value of the portfolio was $62,967.33. The Publication income account, comprising money funds, common stocks and closed end funds had an opening portfolio value of $50,672.95, received $8,164.20 from the prorated distribution and withdrew $9,000 in expenses for an adjusted value of $49,837.15. The closing value was

177

$56,655.20. The Richards income account, comprising money funds and closed end funds had an opening value of $34,931.06, received $11,981.90 from the capital distribution, withdrew expenses of $9,528.65 for an adjusted value of $37,384.31. The closing value was $39,431.59.

Respectfully submitted, The Trustees Esther A.H. Hopkins Michael Strem Joe Lima

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 5-A

SPECIAL PROGRAMS (Web Pages)

Northeastern Section Chemistry Research Conference Undergraduate Research Symposium / BSC

http://www.nesacs.org

178

NSCRC 2007

Saturday, April 21, 2007

MIT The Ray and Maria Stata Center Building 32 32 Vassar Street Cambridge, MA {click here for map and directions}

LATE REGISTRATION HERE

Please note: Posters must fit inside 4' width

Program Schedule:

8:30am - 9:00am Poster Set-Up and Registration, Breakfast

9:00am - 9:15am Welcoming Remarks Laila Dafik

9:15am - 9:30am German Exchange Update--Boston, August, 2007 NSYCC Executive Committee

"Selective Palladium-Catalyzed Arylation of Ammonia" 9:30am - 9:50am David S. Surry (MIT)

"Towards the Chemical Synthesis of an Arm-Chair Carbon Nanotube" 9:50am - 10:10am Richard K. Hughes, Jr. (Boston College)

179

"Scanning Tunneling Microscopy Study of the Dramatic Surface Activity of 10:10am - 10:30am Au{111} at Low Temperatures Due to the Effect of Styrene Adsorption" Ashleigh E. Baber (Tufts University)

10:30am - 10:45am Coffee Break One

"An Isolable and Monomeric Phosphorus Radical that is Stabilized by the 10:45am - 11:05am Vanadium (IV/V) Redox Couple" Paresh Agarwal (MIT)

"Development of an Undergraduate Green Organic Chemistry Laboratory 11:05am - 11:25am Experiment: Reduction Chemistry Involving Polymethylhydrosiloxane (PMHS)" Kathryn O'Brien (Suffolk University)

"Artificial enzymes: In Silico Design and QM/MM Characterization" 11:25am - 11:45am Anastassia N. Alexandrova (Yale University)

11:45am - 12:30pm Lunch

"Total Synthesis of the Marine Metabolite Bistramide A" 12:30pm - 12:50pm Jason T. Lowe (Boston University)

"Genetic Design, Expression, and Properties of Spider Silk-Like Block 12:50pm - 1:10pm Copolymers" Olena S. Rabotyagova (Tufts University)

1:10pm - 2:15pm Poster Session

2:15pm - 2:30pm Break

Keynote Lecture- "Drugging the Undruggable" 2:30pm - 3:30pm by Professor Gregory L. Verdine, Harvard University

3:30pm - 3:50pm Awards Presentation

3:50pm - 4:00pm Closing Remarks, Poster Take-Down

Generous Corporate Sponsors of the 2007 Chemistry Research Conference

180

UNDERGRADUATE ENVIRONMENTAL RESEARCH SYMPOSIUM BRIDGEWATER STATE COLLEGE NOVEMBER 10, 2007

Report on the 6th Annual Undergraduate Environmental Research Symposium Bridgewater State College November 10, 2007 Moakley Center

On Saturday, November 10, 2007, the 6th Annual Undergraduate Environmental Research Symposium was held in the John Joseph Moakley Center at Bridgewater State College. The Symposium ran from 9:00 AM to 2:30 PM and featured 42 poster presentations from under-graduate researchers representing 13 colleges and universities from the New England region. Over 100 students, faculty and mentors were in attendance.

The Symposium was officially opened by Matt Moreau, senior biology major at Bridgewater State College. The welcoming remarks were given by BSC President, Dr. Dana Mohler- Faria. President Mohler-Faria spoke of the critical importance that undergraduate research plays in training students to understand and solve the growing problems in our society related to sustainability, global warming and climate change.

The formal program began at 9:30 AM with a panel discussion moderated by BSC students Todd Miller (senior physics major) and Theresa Peterson (senior biology/chemistry major). The panel discussion focused on the topic: “The Environmental Impact of Global Warming and Climate Change,” and featured: • Senator Marc Pacheco, Chair of the Senate Committee on Global Warming and Climate Change • Dr. Robert Bertin, Biology Department, College of the Holy Cross: "Ecological Effects of Climate Change" • Dr. Rob Hellstrom, Geography Department, BSC, "Processes of Climate Change in New England: Past, Present and Future" • Dr. Deniz Leuenberger, Political Science Department, BSC, “Heating Up: The Rising Politics of Climate Change in the United States and European Union” The poster sessions began immediately following the panel discussion, running from 11:00 – 2:30.

Attendees were treated to a continental breakfast and a deli platter for lunch. The complete program with all presenters, titles and abstracts can be accessed from the symposium web page: http://www.bridgew.edu/Environmental/

SPONSORS  Bridgewater State College  Office of Undergraduate Research and Center for Sustainability  Northeastern Section of the American Chemical Society

181

ANNUAL REPORT Northeastern Section, ACS

APPENDIX 6

YOUNGER CHEMISTS COMMITTEE

http://www.nesacs.org

182

Younger Chemists Committee Report 2007 Submitted by Laila Dafik, Chair NSYCC 2007

I. Overall Evaluation Followed by the events in 2006, the Norheastern Section Younger Chemists Committee (NSYCC) had organized two events during 2007, the NSCRC and the NSCCF in the spring. Furthermore, the local section hosted the 2007 German Exchange Program in August 2007.

II. Officers and Members

The annual report is submitted by the NSYCC chair each year.

NSYCC Officers

Laila Dafik-Chair Department of Chemistry Tufts University 62 Talbot Ave., Medford , MA 02155 Laila[dot]Dafik[at]Tufts[dot]edu 617-627-2558

Deniz Yüksel Department of Chemistry Tufts University 62 Talbot Ave., Medford , MA 02155 Deniz[dot]Yuksel[at]tufts[dot]edu 617-627-3545

Subrahmanian Tarakkad Krishnaji-Webmaster Department of Chemistry Tufts University 62 Talbot Ave., Medford , MA 02155 subbu[dot]tk[at]gmail[dot]com 617-627-2558

Leland L. Johnson, Jr. Chemlee[at]bu[dot]edu Career Chair, NSYCC 617.304.6474

YCC Mentors

Dr. Mukund Chorghade 14 Carlson Circle, Natick, MA 01360 508-651-7809 Chorghade[at]Comcast[dot]net

Dr. Michael Strem-Chair of German Exchange Steering Committee Strem Chemical, Inc.

183

mstrem[at]strem.com

Dr. Ruth Tanner-Chair of NESACS Education Committee University of Massachusetts-Lowell Ruth_Tanner[at]uml.edu

Dr. Morton Z. Hoffman Councilor, Northeastern Section, American Chemical Society Department of Chemistry Tel: 617-353-2494 Boston University

Northeast Student Chemistry Research Conference (NSCRC) 2007 Subcommittee

Chair Laila Dafik, Tufts University

Vice Chairs

Deniz Yüksel, Tufts University

Subrahmanian Tarakkad Krishnaji, Tufts University

Webmasters:

Subrahmanian Tarakkad Krishnaji Leland L. Johnson, Jr.

Program and Printing: Subrahmanian Tarakkad Krishnaji Laila Dafik

Gifts and Journals: Deniz Yüksel Subrahmanian Tarakkad Krishnaji

Arrangements and promotion:

Leland L. Johnson, Jr., Boston University Yulia Ivanova, Tufts University

184

III. Activities Schedules, photographs, and detailed information about each of this year activities are available on the NSYCC website: www.nsycc.org

The NSYCC organized a student conference on Saturday April 21st at the Maria Stata Center, MIT. The keynote speaker was professor Gregory L. Verdine from Harvard University. This year, we had young chemists from all over the Northeastern region: UMass Boston, MIT, Harvard, Tufts, Boston College, Boston University, Suffolk University, Northeastern University, UMass Lowell, University of Hartford, University of Iowa, the Pratt Institute and Bridgewater State College. It was also our pleasure to welcome participants from institutions outside the region including Yale University (New Heaven, CT) and Concordia University (Qc, Canada). Scientists from pharmaceutical companies were also attending our annual Conference, including Dr. Mike Strem from Strem Chemicals inc. and six attendees from Vertex Pharmaceuticals Incorporated. The schedule this year included 8 talks given by postdocs, grad students and undergrads. At the end of the day Prof. Verdine gave a lecture about "Drugging the Undruggable". Eight superb awards were given to the best oral and poster presentations.

Award-Winning---Oral Presentation

"Genetic Design, Expression, and Properties of Spider Silk-Like Block Copolymers" Olena S. Rabotyagova, PhD Candidate, Tufts University Winner, AstraZeneca "Excellent Oral Presentation," 500 dollar, top award

"Selective Palladium-Catalyzed Arylation of Ammonia" David S. Surry, Post Doctoral Fellow, MIT Winner Vertex Pharmaceuticals and Strem Chemicals "Excellent Oral Presentation," 500 dollar, top award

Award-Winning---Poster Presentation Poster Presentations "Synthetic Studies Towards Polyprenylated Phloroglucin Natural Products"

Ji Qi , PhD Candidate, Boston University Winner, Vertex Pharmaceuticals Award for "Excellence in Graduate Research," Poster Presentation 200 dollars

"Fiber Optic Single Cell Drug Screening"

Ragnhlid Whitaker, Ph D Candidate, Tufts University Winner, Vertex Pharmaceuticals Award for "Excellence in Graduate Research," Poster Presentation 200 dollars

"A Novel One-Pot Synthesis of N-Acylindoles by Successive Cycloalkylation/Annelation of Primary Aromatic Amides"

185

Omar De Paolis , UMass, Boston Winner, Vertex Pharmaceuticals Award for "Excellence in Undergraduate Research," Poster Presentation 200 dollars

"Engineering a Monovalent Avidin"

Jessica Lynch , MIT Winner, Vertex Pharmaceuticals Award for "Excellence in Undergraduate Research," Poster Presentation 200 dollars

"Interactions of Rh(I) and Rh(III) Cationic Complexes with Simple Monosaccharides"

Sarah Lane , Bridgewater State College Winner, Graduate Women in Science Award for "Excellence in Undergraduate Research," Poster Presentation 200 dollars

"An Isolable and Monomeric Phosphorus Radical that is Stabilized by the Vanadium(IV/V) Redox Couple"

Paresh Agarwal , MIT

Winner, Brauner Book Award for "Excellent Undergraduate Research," Oral Presentation 200 dollars

Judge Committee consisted of: • Dr. Mike Strem (Strem Chemical Incorporated) • Dr. Ruth Tanner (UMass Lowell) • Dr. Anne-Laure Grillot (Vertex Pharmaceuticals Incorporated) • Dr. Penny Beuning (Department of Chemistry and Chemical Biology Northeastern University, www.gwisboston.org) • Dr. Kathryn Jones, Massachusetts Institute of Technology (www.gwisboston.org)

4th Annual Northeast Student Chemistry Career Fair (April 19th, 2007)

During last year, the NSCCF was held on Thursday, April 19th, 2007 from 3PM - 7PM, at the Brookline Holiday Inn, Brookline, MA. We have had 110 registered job seekers and 10 corporate recruiters on-site. Dr. Dan Eustace gave a workshop session focused on the Preparation for Life After Graduate School program. The session consisted of four-33 minute segments and one-70 minute segment, covering finding jobs (33 min), critical skills- communications (33 min), resume writing (33 min), interviewing (33 min), and mock interview demonstration (70 min). The resume reviewers who helped during ACS career fair were:

Gary Lavine Sheila Rodmann

186

Barry Mahoney Patrick Gordon Louie Kirschenbaum

The career Fair was a success!!

Corporate recruiters present on the career fair day were :

Seventh annual NESACS-YCC/GDCh-JCF Exchange Program (August 18th-25 th)

The Northeastern Section of the ACS (NESACS), its Younger Chemists Committee (YCC), and its Education Committee welcomed to Boston this past summer 14 representatives of Young Chemists Forum (Jung- Chemikerforum, JCF), who had been selected by the German Chemical Society (Gesellschaft Deutscher Chemiker, GDCh), accompanied by Dr. Kurt Begitt, Deputy Excutive Director and Director of Education and Professional Affairs of the GDCh and Dr. Marianne Sgoff, a high school teacher of chemistry in Germany. The visit came as the seventh annual exchange program between the NESACS-YCC and GDCh-JCF, which spotlights the close connection between the ACS and the GDCh.

The one weeklong program of the German delegation visit began on Sunday, August 19th, with the first day of the ACS National meeting. On Sunday morning, Dr. Marianne Sgoff spoke in the CHED High School Program (The High School-College Interface). In addition, on Sunday afternoon four students and Dr. Begitt contributed with oral presentations in a symposium in the Division of Chemical Education (CHED), titled Connections to Germany: Research and Education Opportunities. At the end of the day, NESACS hosted a reception in their honor where the German contingents had the opportunity to experience their first social event in the program. On Monday evening, the German delegation attended the ACS and Board staff reception upon an extended invitation from Madeleine Jacobs, Executive Director and CEO of ACS, followed by Sci-Mix poster session where the German Graduate students displayed their research posters and discussed their scientific progress.

In additions to the scientific talks, the program included an excursion to the Woods Hole Oceanographic Institute, visits to local universities and laboratories. At the farewell dinner, Dr. Kurt Begitt was awarded the Golden ACS plaque, which recognizes his outstanding service to chemistry and the chemical society, for his work in promoting the JCF-YCC exchange program.

The 2007 German Exchange program gave the German delegation the opportunity to present their research, network with the other graduate students including NSYCC including experience the social events associated with the national meeting. In addition, the ACS meeting was a forum to discuss career opportunities such as possible postdoctoral positions for the German graduate students.

Looking ahead to the 2008 exchange program, the application is now available. A delegation from NESACS will travel to Rostock, March 27-29 for the Frühjahrssymposium. The deadline for the submission of applications is November 8th. We hope that NESACS-YCC and GDCh- JCF exchange continues and we look forward to greet JCF to Boston in August 2010.

IV. Budget The Northeast Student Chemistry Career Fair and the 9th annual NSCRC (co-spponsored by Education Committee)

187

Budget Expenses $ 10920.00 Income $ 5000.00 Net section expense $ 5920.00

The YCC has charged the companies participating in the career Fair $500 each for their booth space. The remainder of all funds was received from the Northeastern Section of the American Chemical Society (NESACS).

V. Future Plans The NSYCC is now in the process of organizing the 2008 career fair and the NSCRC which will be held in April 2008. Looking ahead at the German Exchange Program, students were chosen from different schools by the German Exchange Program Steering Committee in the section to travel to Germany and participate in the spring Frühjahrssymposium symposium in Rostock.

Pictures from the NSCRC Day

Olga Makhlynets (Tufts University) explaining her research to Dr. Anne-Laure Grillot

(Judge) Thinking

Poster Session-Place II

188

Poster session

Victoria L. Campbell explaining her research.

Dr. Penny Beuning during the poster session.

189

Dr. Anne-Laure Grillot before the award presentation

Prof. Verdine during the poster session

Poster session-Place II

190

NSCRC Awardees, Dr. Ruth Tanner, Dr. Anne-Laure Grillot, Dr. Penny Beuning Dr. Kathryn Jones, Laila Dafik, Lee Johnson, and Prof.Greg Verdine

.

191

Dr. Anne-Laure Grillot before the award presentation

Prof. Verdine during the poster session

Poster session-Place II

192

NSCRC Awardees, Dr. Ruth Tanner, Dr. Anne-Laure Grillot, Dr. Penny Beuning Dr. Kathryn Jones, Laila Dafik, Lee Johnson, and Prof.Greg Verdine

193

ANNUAL REPORT Northeastern Section, ACS

PART III

ANNUAL FINANCIAL REPORTS

Financial Reports are included below and uploaded into S.O.L.A.R.

http://www.nesacs.org

194

PART III - 2007 ANNUAL FINANCIAL REPORT Section Northeastern ACS Group Exemption number is 0945

A -- Statement of Revenues and Expenses Operating Funds Maps to IRS Form 990E-Z Line # Amount for Line

(1) Annual ACS allotment (1) $31,813.00 3 Subtotals

(2) New member commissions (2) $60.00 1 (3) Donations, contributions (3) $40,180.00 1

(3a) Bequests and/or trusts (list amount separately from line 3) (3a) $0.00 1

(4) Rebate from ACS for Councilor travel expenses (4) $14,656.25 1 $54,896.25 (5) Program revenue (includes newsletters, short courses, lecture series, (5) $66,660.12 2 $66,660.12 national or regional meetings, etc.)

(6) Local Section dues, affiliate dues (6) $57,073.99 3 $88,886.99

(7) Interest, dividends (7) $131.29 4 $131.29

(8) Special Events and activities (describe and itemize in an attachment; the purpose of these is to raise funds that are other than contributions to finance exempt activities. Include events such as dinner dances, raffles, bingo games, etc.)

(8a) Gross revenue (not including $______of contributions reported on line 3) (8a) $0.00 6a $0.00

(8b) Less: direct expenses other than fundraising expenses (8b) $0.00 6b $0.00

(8c) Net income (or loss) from special events and activities (line 8a less line 8b) (8c) $0.00 6c $0.00 (9) Meals (include total meals revenue) (9) $6,220.00 8

(10) Other revenue (describe and itemize) (10) $99,729.79 8 $105,949.79

(11) Total Revenues (add lines 1 through 7 and 8c through 10) (11) $316,524.44 will equal line 9 excluding realized Expenses capital gains(losses) (12) Subsidies to subsections, topical groups, or affiliate groups (12) $3,781.19 10

(13) Awards, scholarships, grants, etc. (13) $33,186.00 10 $36,967.19

(14) Administrative expenses (not including postage, printing, and shipping) (14a) Salaries, other compensation (14a) $0.00 12 $0.00

(14b) Professional fees and payments to independent contractors (14b) $46,664.50 13 $46,664.50

(14c) Occupancy, rent, utilities, and maintenance (14c) $1,885.24 14 $1,885.24

(14d) Total administrative expenses (add lines 14a through 14c) (14d) $48,549.74

(15) Printing, publications, newsletters, meeting announcements, postage, (15) $62,548.12 15 $62,548.12 and shipping

(16) Local meetings (include speakers’ expenses) (16) $72,129.59 16

(17) Meals (include total meal expenses) (17) $50,916.92 16

(18) Travel subsidies to Councilors (18) $20,266.02 16

(19) Travel subsidy and fee for Local Section Leadership Conference (19) $516.20 16

(20) Other expenses (describe and itemize) (20) $10,573.07 16 $154,401.80

(21) Total Expenses (add lines 12, 13, and 14d through 20) (21) $302,466.85 will equal line 17

(22) EXCESS (DEFICIT) (Line 11 less line 21) (22) $14,057.59 will equal195 line 18 excluding capital gains (losses)

B – Balance Sheet as of 12/31/07

(23) Investments (estimated current market value of stocks and bonds) (23) $2,605,288.27 22

Of the amount cited in line 23, indicate how much is restricted by external donor stipulation for uses such as awards funds, building funds, etc. List individual accounts, if possible. (23a) attached Fund (23a)

(23b) Fund (23b)

(23c) Fund (23c)

(23d) Fund (23d)

Total Restricted Funds (add lines 23a, 23b, 23c, 23d) $2,731,877.96

(24) CDs, Money Markets (24) $189,557.02 22

(25) Cash on hand (passbook savings and checkbook) (25) $37,531.76 22 $2,832,377.05

(26) Other assets (describe and itemize) (26) $0.00 24 $0.00

(27) Total Assets (add lines 23, 24, 25 and 26) (27) $2,832,377.05 25 $2,832,377.05

(28) Average interest earned on assets (%): 9.16% ______

(29) Liabilities, if any (29) $0.00 26 $0.00

(30) Net assets, 12/31/07 (line 27 less line 29) (30) $2,832,377.05 27 $2,832,377.05

(31) Last Year's Net assets, 12/31/06(line 30, 2006 report) (31) $2,694,727.40 19 $2,694,727.40

(32) EXCESS (DEFICIT) (line 30 less line 31) (32) $137,649.65

(33) EXCESS (DEFICIT) from line 22 (33) $14,057.59 will equal line 13

(On a separate attachment, explain any differences between lines 22 and 32)

Public Support Test or Reason for Non-Private Foundation Status. Local sections must normally receive more than 33 1/3% of its support donations from the general public and not more than 33 1/3% of its support from investment income. NOTE: A section that fails the test for 2 consecutive years loses its public charity status and becomes a private foundation.

Public Support Ratio = 100.0% PASS Gifts, Grants, Contributions, Membership Dues & Exempt Function Revenues = Line (1+2+3+4+5+6+9+10) * Gifts, Grants, Contributions, Membership Dues, Exempt Function Revenues, = Line 11 Interest, Unrelated Business Income, Tax Revenues, Value of Services & Facilities, Other Sources * Exclude any unrelated business income

Gross Investment Income Ratio = 0.0% PASS Gross income from interest & dividends = Line 7 Gifts, Grants, Contributions, Membership Dues, Exempt Function Revenues, = Line 11 Interest, Unrelated Business Income, Tax Revenues, Value of Services & Facilities, Other Sources

Was your section required to file any IRS Tax Forms in 2007? _____ Yes, we filed form(s) ______No

Name: James U. Piper Councilor Name:

Office: Treasurer

Signature: Signature: Date: Date: Please return TWO copies by February 15, 2008 to: American Chemical Society, Office of Executive Director, c/o Office of Local Section Activities, 1155 16th Street, NW, Washington, DC 20036

196

Attachments to 2007 Financial Report

Itemization of Other Income and Expense

Other income, Line 10 Distributions from Trust Funds to Operating Acct 99,672.99 Telephone tax refund 51.94 Reimbursements 4.86 99,729.79 Other expense, Line 20 Fundraising (Golf Tournament) 10,573.07

Attachments to 2007 Financial Report

Line 23 Restricted Funds (including restricted cash) Consolidated Account 2,039,626.68 Esselen Trust 536,662.13 Richards Trust Inc Acct 39,431.59 Norris Trust Inc Acct 1,847.94 Publications Trust Inc Acct 56,655.20 Hill Trust Inc Acct 18,969.64 Levins Award Fund 11,066.81 Brauner Memorial Trust 27,617.97 Total 2,731,877.96

Reconciliation of lines 22 and 32 Opening balance adjustment 0.00 Increase in operating cash (Line 22) 14,057.59 Norris National Award paid from Norris (7,794.00) Trust Div/Int income not used for operations 47,819.65 Realized gain (loss) from sales (396.34) Unrealized gain (loss) 91,652.41 Mgt fees & tax pd in trust accts (7,689.66) - Line 32 137,649.65

Support ratios (calculations on p2 are incorrect) Gifts, grants and contributions 86,709.25 Membership fees 57,073.99 Exempt function revenues 72,880.12 Dividend/interest income 147492.64 Public support ratio 0.59 Investment income ratio 0.41

197

ANNUAL REPORT Northeastern Section, ACS

PART IV

SELF-NOMINATIONS FOR CHEMLUMINARY AWARDS

Outstanding Performance by a Local Section -  Very Large Size Category Local Section Activities Committee Awards  Most Innovative New Activity or Program in a Local Section  Best Activity or Program in a Local Section Stimulating Membership Involvement Local Section Career Program Awards  Outstanding Local Section Career Program Younger Chemists Committee Awards for Local Sections and Divisions  Outstanding or Creative Local Section Younger Chemists Committee Event ChemLuminary Awards for National Chemistry Week  Outstanding Event for a Specific Audience  Best High School Event

http://www.nesacs.org

198

ChemLuminary Award Nomination - 1

Local Section: Northeastern

Award Category: Outstanding Performance Award by Local Section Very Large Size Category Award

Contact Person: Name Mukund S Chorghade Address THINQ Pharma, 14 Carlson Circle, Natick, MA 01760-4205 Phone 508-651-7809 Fax 508-651-7920 E-mail [email protected]

Description of Activity/Program: Please provide a synopsis of the activity/program and state clearly, in 1,000 words or less, why the activity/program merits consideration for this particular award. Only activities/programs that were held in 2007 are eligible for consideration. You may wish to include the following in your description: Name of Activity/Program; Date Conducted; Site/Location; Number of Participants. Please refer to the specific guidelines for each award. Descriptions are limited to 1,000 words or less.

Description of Activity/Program: The Northeastern Section had an outstanding year. A seminal event this year was the inaugural “Advances in Chemical Sciences Symposium” conference: it was a spectacular success. Under the auspices of this conference, eminent scientists from the strategic triad of government and industry and academia delivered plenary lectures. The conference brought together 230 scientists for a scholarly event focusing on medicinal chemistry, organic synthesis and methodology. The topical focus areas – medicinal chemistry, pharmaceutical and organic synthesis are areas where the chemical enterprise in our area has a well deserved reputation for excellence.

A large number of pharmaceutical and biotechnology industry professionals attended, shared ideas and built networks. Attendees were treated to some exhilarating science from the finest practitioners of the discipline. A vendor show was well appreciated. We have significantly and dramatically increased the volunteers and participants in our section We have been extremely successful in fostering greater professional interactions with the chemical societies such as the International Union of Pure and Applied Chemistry and the Royal Society of Chemistry: The annual symposium described above will be routinely co-sponsored (intellectually and financially) by them. We also forged links with other area groups: the Boston Area Group for Informatics and Modeling and NOBCChE, the Boston Regional Inorganic Chemistry group (BRIC), the local Analytical Lab Managers Association (ALMA) group, and the New England Board of Higher Education (NEBHE) to provide programming relevant to our diverse membership. Our active Medicinal Chemistry (MedChem) Group organized three well- attended programs in May, September, and December. MedChem meetings were thematic in nature and were organized around diseases.

We have been extraordinarily efficient and successful in refining the “Career Services” events, co-opting of professional recruiters on our committee and expanding the range of services to outside our section area. We provided ACS Members with the best and latest tools to manage careers: guidance and focus on the components of targeting the job market, personal assessment, identifying market trends, credentials, research and networking. We organized a comprehensive (lecture, demo and review) program that provided assistance in writing winning resumes and cover letters, learning various techniques and skills needed for a successful job interview and negotiating an attractive job offer. We strategically expanded our electronic activities. We updated the section’s

199

website: www.nesacs.org Dan Eustace, set up a section blog, available at URL: blog.nesacs.org, It enjoys 800- 1000 hits per day!

Mukund Chorghade, Chair actively participated in the work of the ACS Department of Career Services and Professional Development. Dr. Daniel Eustace was a most welcome and effective contributor to these. We have helped in redesigning and participating in several innovative ACS presentations and personally leading highly and superbly interactive and novel workshops on interviewing, career development etc. Dan Eustace and Mukund Chorghade were selected to participate in the ACS National “Train the Trainer’s Program” We held regular Career Services Employment Seminars preceding the regular meeting of the Northeastern Section. As an innovative attempt to network employment-seekers with professional recruiters, we co-opted two highly respected industry professionals Megan Driscoll and Jennifer Sass, Pharmalogics recruiting, to our team. They assisted some job- seekers get interviews and eventually placements within the pharmaceutical and biotech industries even in locations such as Kansas.

Science Café’s organized via the speaker’s bureau were outstanding. We revitalized the speaker’s bureau, assembled the best talent in our section and got a list of refined presentations of broad general interest. A major event was a “Science-Café” in collaboration with Professor Kathi Browne of Natick High School: we organized this two-hour “in-house field trip for 150 of the best students and faculty at Natick High. Executives from the Pharma and biotech industry provided insights into: Ashdown and other scholarship exams, Chemistry Olympiad (Steve Lantos) 2) The use of Chemistry, setting up a Science Club (Mukund Chorghade) 3) The excitement of Chemistry and Science (Dan Eustace) 4) Careers, internships (John Amedio). We were able to organize a second event and have Dr. David Pizzi, Sr. Director, Shire Therapeutics visit the school for individual classroom discussions and Q & A. A delightful spin-off was the organization of a Science Club at Natick High School. for promoting the study of Chemistry. Kathy Brown of Natick High School was successful in securing an NSF grant to encourage students to participate in and compete in local science competitions. such as the Science Bowl and the Women in Science Competition.

Education events organized by Ruth Tanner and Steve Lantos were superb. The 2007 Connections to Chemistry program was held at Burlington High School with 112 High School Chemistry teachers from 72 schools from Massachusetts, Maine, New Hampshire and Connecticut. Each received the October issue of the Journal of Chemical Education with a username and password for temporary full access to JCE Online (October 17 – November 17, 2007) and a copy of a recent issue of C&EN. In addition, each participant received a year’s subscription to ChemMatters, and a certificate for three hours of Professional Development. Five workshops were offered: each teacher participated in two of them. Mukund Chorghade presented a workshop on Careers in Chemistry. Terri Taylor presented a workshop at the program on the high school chemistry initiative by the ACS.

Events at the Science Museum-Christine Jaworek were a “celebration of chemistry in the truest” sense of the word. Seventeen posters were submitted for the NCW poster competition. More than 50 volunteers from nine organizations assisted in the running of the hands-on activities and demonstrations. Approximately 300 individuals attended Dr. Bassam Shakhashiri’s lecture demonstrations at the Museum. A “Salutes to Excellence” Award was presented to Dr. Bassam Shakhashiri. Many visitors to the Museum were also able to talk with the scientists in attendance. Over 1300 individuals came to the BCM that day.

We were able to help Amrita Karambelkar secure an internship at Tufts Medical School. She was very excited about this, did a project and is now a co-author of a published paper. She was the first high school senior (accepted at Harvard and MIT) to write a special article for the Nucleus.

Our signature program regarding collaboration with GDCh gained strength There were several technical symposia at which NESACS members presided. Former NEASCS Chair and current Councilor, Mort Hoffman, delivered the keynote address, “Exploring the High School-College Interface,” at the Division of Chemical Education’s High School Program. The Division of Chemical Education, collaborating with many other ACS Divisions and

200

Committees, sponsored the symposium, “Connections to Germany: Research and Education Opportunities”, at which participants in NESACS’s signature German Exchange Program were be featured.

The Division of Professional Relations held a symposium in honor of NESACS’s Arlene and Ted Light, the 2007 recipients of the ACS Henry Hill Award conferred by the Division. The symposium included Elaine Diggs and John Sophos of ACS, Dan Eustace of Multi-Layer Coating Technologies; and James Burke, former Chair of the ACS Board of Directors. The symposium proved to be a fitting tribute to the Lights’ many contributions to ACS.

Michaeline Chen identified a Boston University music student, Patrick Doyle who at the beginning of the Council meeting, performed a fanfare of his own composition, which was greeted by enthusiastic applause and cheering.

Doris Lewis spearheaded the formation of a special Government Affairs Committee to more effectively liaise with our leaders at the local and federal government level.

Networking events provided a fertile forum for NESACS members to meet fellow chemists in a very informal professional setting. Amy Tapper hosted a golf tournament at which several executives from innovator companies and contract research organizations intermingled for “friendly rivalry”, camaraderie and sportsmanship. There were other networking get-togethers designed to afford our members to expand their intellectual and professional horizons.

Abstract: The Northeastern Section had an outstanding year with several innovative programs and selectively adding new ones. Notable activities include: organization of a Life Sciences Symposium that brought 200+ scientists, dynamic career services activities, a novel High School event that led to the establishment of a Science Club, a 3-site National Chemistry Week event utilizing over 100 volunteers from twelve organizations including area high schools, colleges, universities and private industry that reached 3,000 visitors, and a blog, available at URL: blog.nesacs.org, focused on providing career development advice to area chemists.

Professor Robert Grubbs, Mrs. Helen Grubbs and NCW Activity at the Museum of Science Boston Mike Strem judge the fine wines at the symposium reception

201

ChemLuminary Award Nomination - 2

Local Section: Northeastern

Local Section Activities Committee Awards Categpry: Most Innovative New Activity or Program in a Local Section.

Contact Person Name: Dr. Daniel Eustace Address: 5 Doty's Mill Road Dartmouth, MA 02743 Phone: 508-742-3443 Email: [email protected]

Description: NESACS Journal Donation to Argentina Program

This project was the brain-child of Daniel Eustace and fellow members who selflessly donated their personal copies of chemical journals in the Northeastern Section. The idea is to recognize that although we in the US are moving fast to a digital age where all of our technical literature is available online, it is not the same for our colleagues in other nations. In fact, it is difficult to even do routine literature searches because of lack of resources. When the international divisions Book donation program headed by Joyce Torio was discontinued in 2006, we started a journal donation program to the libraries of Argentina, through the Argentine Chemical Society. Initiated in 2006 with a visit, the program picked up in 2007 with over 300 pounds of high quality chemical journals being donated. To date, over 500 pounds of journals worth the libraries of Argentina over $100,000 have been received.

The response in Argentina was incredible. Banner headlines appear in the AQA web-magazine announcing the donations. The AQA invited Dan to author broad interest and focused articles for the one thousand member society to learn about. Cross cultural invitations to exchange ideas and approaches.

The program is supported in New England by announcements and articles in our local section Nucleus. What do we do with our journal collections that we now have available online? There is something more meaningful and lasting to the profession than putting them in recycling—donate them to Argentina!

Abstract: Northeastern Local Section members have coordinated a book and journal donation program to the country of Argentina to share our valuable technical resources with fellow scientists who are most hungry for our help. Through personal initiative and selfless actions our local section has donated over 500 pounds of books and journals worth over $100,000 to the library of Asociacion Quimica Argentina.

Philanthropic Gesture Leads to International Friendship

(L-R) are M. Clelia Garnelo (bibliotecaria), Dr. Maximo Baron (director), Dr. Lydia Galagovsky (Univerisidad de Buenos Aires), Dan Eustace, and Dr. Carlos Durruty (biblioteca).

202

ChemLuminary Award Nomination - 3

Local Section: Northeastern

Local Section Activities Committee Awards Categoru: Best Activity or Program in a Local Section Stimulating Membership Involvement

Contact Person: Name Mukund S Chorghade Address THINQ Pharma, 14 Carlson Circle, Natick, MA 01760-4205 Phone 508-651-7809 Fax 508-651-7920 E-mail [email protected]

Description of Activity/Program: The Northeastern Section wishes to be considered for this outstanding event. We had a new activity that greatly excited the membership, stimulated greater involvement of volunteers and promises to be the forerunner of an annual series of events. A seminal event this year was the inaugural “Advances in Chemical Sciences Symposium” conference, held on March 30, 2007: it was a spectacular success. The symposium was a day-long celebration of Chemistry and was held at the Royal Sonesta Hotel in Cambridge, MA. Under the auspices of this conference, eminent scientists from the strategic triad of government and industry and academia delivered plenary lectures. The conference brought together 230 scientists for a scholarly event focusing on medicinal chemistry, organic synthesis and methodology. This year’s plenary lecturers included, Robert Grubbs (Caltech), Steven Ley (Cambridge)), Eric Jacobsen (Harvard), Tomi Sawyer (Pfizer), William Greenlee (Schering Plough) and Mark Murcko (Vertex). The topical focus areas – medicinal chemistry, pharmaceutical and organic synthesis are areas where the chemical enterprise in our area has a well deserved reputation for excellence.

A large number of pharmaceutical and biotechnology industry professionals from the metropolitan area joined us for this event, shared ideas and built networks. The response was extremely enthusiastic. A sell out symposium crowd was treated to some exhilarating science from some of the finest practitioners of the discipline. A vendor show was well attended and appreciated. All the vendors participated fully in the scientific deliberations and have set up follow-up meetings to stimulate business. The symposium was co- sponsored by the US (East Coast) Section of the RSC, and IUPAC. This helped cement our relationships with our colleagues from other societies. Represented on the organizing committee were scientists from many of the Pharma companies in our area. We thus built a nucleus for the future: there is a lot of enthusiasm for having this as an annual event; the 2008 event is being organized: the scheduled date is April 11

We have significantly and dramatically increased the volunteers and participants in our section We have been extremely successful in fostering greater professional interactions with the chemical societies such as the International Union of Pure and Applied Chemistry and the Royal Society of Chemistry: The annual symposium described above will be routinely co-sponsored (intellectually and financially) by them. We also forged links with other area groups: the Boston Area Group for Informatics and Modeling and NOBCChE, the Boston Regional Inorganic Chemistry group (BRIC), the local Analytical Lab Managers Association (ALMA) group, and the New England Board of Higher Education (NEBHE) to provide programming relevant to our diverse membership. Our active Medicinal Chemistry (MedChem) Group followed up by organizing three well-attended programs in May, September, and December. MedChem meetings were thematic in nature and were organized around diseases.

Please provide a 2-3 sentence abstract that describes your activity.

203

Abstract: The Northeastern Section had an outstanding year with several innovative programs including one to stimulating membership involvement

Notable was the organization of a Life Sciences Symposium that brought 230+ scientists, wherein eminent scientists from the strategic triad of government and industry and academia delivered plenary lectures. A large number of pharmaceutical and biotechnology industry professionals from the metropolitan area joined us for this event, shared ideas and built networks. The response was extremely enthusiastic. A sell out symposium crowd was treated to some exhilarating science from some of the finest practitioners of the discipline. A vendor show was well attended and appreciated. We have significantly and dramatically increased the volunteers and participants in our section We have been extremely successful in fostering greater professional interactions with the chemical societies such as the International Union of Pure and Applied Chemistry and the Royal Society of Chemistry: The annual symposium described above will be routinely co-sponsored (intellectually and financially) by them.

Philanthropic Gesture Leads to International Friendship

(L-R) are M. Clelia Garnelo (bibliotecaria), Dr. Maximo Baron (director), Dr. Lydia Galagovsky(Univerisidad de Buenos Aires), Dan Eustace, and Dr. Carlos Durruty (biblioteca).

Symposium Vendor Fair: Vendors displayed new technologies of current interest to Medicinal Chemists

204

ChemLuminary Award Nomination - 4

Local Section: Northeastern

Local Section Career Program Awards Category: Outstanding Local Section Career Program Award

Contact Person: Name Mukund S Chorghade Address THINQ Pharma, 14 Carlson Circle, Natick, MA 01760-4205 Phone 508-651-7809 Fax 508-651-7920 E-mail [email protected]

Description of Activity/Program: Please provide a synopsis of the activity/program and state clearly, in 1,000 words or less, why the activity/program merits consideration for this particular award. Only activities/programs that were held in 2007 are eligible for consideration. You may wish to include the following in your description: Name of Activity/Program; Date Conducted; Site/Location; Number of Participants. Please refer to the specific guidelines for each award. Descriptions are limited to 1,000 words or less.

The Northeastern Section wishes to be considered for an outstanding contribution and commitment to Career Services We have been extraordinarily efficient and successful in refining the “Career Services” events, co-opting of professional recruiters on our committee and expanding the range of services to outside our section area. We provided ACS Members with the best and latest tools to manage careers: guidance and focus on the components of targeting the job market, personal assessment, identifying market trends, credentials, research and networking. We organized a comprehensive (lecture, demo and review) program that provided assistance in writing winning resumes and cover letters, learning various techniques and skills needed for a successful job interview and negotiating an attractive job offer. We strategically expanded our electronic activities. We updated the section’s website: www.nesacs.org Dan Eustace, set up a section blog, available at URL: blog.nesacs.org, It enjoys 800- 1000 hits per day!

Mukund Chorghade, Chair actively participated in the work of the ACS Department of Career Services and Professional Development. Dr. Daniel Eustace was a most welcome and effective contributor to these. We have helped in redesigning and participating in several innovative ACS presentations and personally leading highly and superbly interactive and novel workshops on interviewing, career development etc. Dan Eustace and Mukund Chorghade were selected to participate in the ACS National “Train the Trainer’s Program” We held regular Career Services Employment Seminars preceding the regular meeting of the Northeastern Section. As an innovative attempt to network employment-seekers with professional recruiters, we co-opted two highly respected industry professionals Megan Driscoll and Jennifer Sass, Pharmalogics recruiting, to our team. They assisted some job- seekers get interviews and eventually placements within the pharmaceutical and biotech industries even in locations such as Kansas.

Science Café’s organized via the speaker’s bureau were outstanding. We revitalized the speaker’s bureau, assembled the best talent in our section and got a list of refined presentations of broad general interest. A major event was a “Science-Café” in collaboration with Professor Kathi Browne of Natick High School: we organized this two-hour “in-house field trip for 150 of the best students and faculty at Natick High. Executives from the Pharma and biotech industry provided insights into: Ashdown and other scholarship exams, Chemistry Olympiad (Steve Lantos) 2) The use of Chemistry, setting up a Science Club (Mukund Chorghade) 3) The excitement of

205

Chemistry and Science (Dan Eustace) 4) Careers, internships (John Amedio). We were able to organize a second event and have Dr. David Pizzi, Sr. Director, Shire Therapeutics visit the school for individual classroom discussions and Q & A. A delightful spin-off was the organization of a Science Club at Natick High School. for promoting the study of Chemistry. Kathy Brown of Natick High School was successful in securing an NSF grant to encourage students to participate in and compete in local science competitions. such as the Science Bowl and the Women in Science Competition.

Education events organized by Ruth Tanner and Steve Lantos were superb. The 2007 Connections to Chemistry program was held at Burlington High School with 112 High School Chemistry teachers from 72 schools from Massachusetts, Maine, New Hampshire and Connecticut. Each received the October issue of the Journal of Chemical Education with a username and password for temporary full access to JCE Online (October 17 – November 17, 2007) and a copy of a recent issue of C&EN. In addition, each participant received a year’s subscription to ChemMatters, and a certificate for three hours of Professional Development. Five workshops were offered: each teacher participated in two of them. Mukund Chorghade presented a workshop on Careers in Chemistry. Terri Taylor presented a workshop at the program on the high school chemistry initiative by the ACS.

Abstract: We have been extraordinarily efficient and successful in refining the “Career Services” events, co-opting of professional recruiters on our committee and expanding the range of services to outside our section area. We provided ACS Members with the best and latest tools to manage careers: guidance and focus on the components of targeting the job market, personal assessment, identifying market trends, credentials, research and networking. We organized a comprehensive (lecture, demo and review) program that provided assistance in writing winning resumes and cover letters, learning various techniques and skills needed for a successful job interview and negotiating an attractive job offer.

206

ChemLuminary Award Nomination - 5

Section: Northeastern

Award Category: Outstanding or Creative Local Section Younger Chemists Committee Event

Contact Person:

Name Laila Dafik

Address: Department of Chemistry 62 Talbot Ave. Medford, MA 02155 Phone: (617) 627-2558 Fax: (617) 627-3443 E-mail: [email protected]

The NESAC-YCC had continued success with their annual career services events, the career symposium and the career fair. Career symposium 2007: The Preparation for Life After Graduate School program (April 19, 2007).

• The NSCCF was held on Thursday, April 19th, 2007 from 3PM - 7PM, at the Brookline Holiday Inn, Brookline, MA. We had 110 registered job seekers and 9 corporate recruiters on-site. Dr. Dan Eustace gave a workshop session focused on the Preparation for Life After Graduate School program. The session consisted of four-33 minute segments and one-70 minute segment, covering finding jobs (33 min), critical skills-communications (33 min), resume writing (33 min), interviewing (33 min), and mock interview demonstration (70 min).

• The NSCCF program consisted of resume reviewers who helped during ACS career fair including Dr. Gary Lavine, Dr. Dr. Sheila Rodmann, Dr. Patrick Gordon, and Dr. Barry Mahoney.

• ACS career services booklets and materials were provided to all attendees during the career fair.

• Company recruiters had access to a digital resume library of all attendees prior the career fair.

• Representative from 9 regional companies made themselves available for employment and career opportunities. With ~110 attending younger chemists. Companies that attended include, Spring Born Smithers, Broad Institute, Sigma-Aldrich, Eisai, ClinLab, Wyeth, Momenta, Waters, and Merck.

• The NESACS-YCC had a continued success with their annual career services events. The local section is now in the process of organization of the 2008 career fair which will held on April 17th 2008.

207

Abstract: The NESAC-YCC had continued success with their annual career services events, the career symposium and the career fair. Career symposium 2007: The Preparation for Life After Graduate School program that attracted 110 registered job-seekers and nine corporate recruiters. The symposium speakers focused on various aspects of job-seeking including finding jobs, resume-writing, critical communication skills, and interviewing.

208

ChemLuminary Award Nomination - 6

2007 National Chemistry Week ChemLuminary Awards Nomination Form

Local Section: Northeastern

Award Category: Outstanding Event for a Specific Audience

Contact Person:

Name Christine Jaworek-Lopes

Address Emmanuel College, 400 The Fenway, Boston, MA 02115

Phone 617-264-7614

Fax 781-335-8598

E-mail [email protected]

Part A: Provide a brief description to each of the following:

1. Estimate the size of the audience reached >400

2. List the ways the event was publicized

The Museum of Science – Boston handled the publicity for this event as the event was designed for high school students. Emails were sent to the teacher listserv informing them of the event. In addition, a portion of the event was open to the general public after the high school students had completed their visits. That was publicized in the daily flyer published by the Museum. In addition, there was signage at the Museum directing visitors to the event.

3. Approximately, how many volunteers assisted prior to and during the event? 25

4. What percentage of volunteers were ACS members? ~30%

5. In the spaces provided, approximately how many volunteers were from each category?

High School Students

4 College Students

3 Academic Professionals

3 Industrial Professionals

209

Government Professionals

15 Other (please categorize) – 10 from museums, 2 Boston Crime Lab, 3 from non-profit organizations

6. In relation to the geographic size of your local section, briefly discuss the number of geographic areas or communities reached during your event.

The majority of attendees in the program were from the greater Boston area (Medford, Boston, Malden, Needham). We did have students from Western MA and Rhode Island participate in the event. We reached a much larger area then originally anticipated.

Part B: In 750 words or less, please provide a synopsis of the activity/event and state clearly why the activity/event merits consideration for this particular award. Only activities held in 2007 for NCW are eligible for consideration. Please refer to the specific guidelines and judging criteria for this award.

On October 22, 2007, a diverse audience of 225 area high school students participated in a daylong program at the Museum of Science-Boston highlighting the variety of careers impacted by chemistry. This program was funded by receipt of a Local Section Innovative Grant, local section funds, and a donation from Merck Research Laboratory – Boston. Each student received free admission to the museum as well as a bag containing a notebook, a pen, the current issue of Chem Matters, the current issue of Celebrating Chemistry, a periodic table of elephants, a nanomole, and a bag of UV-sensitive beads. Each teacher received in addition to the student bags a mug and the ACS pamphlet entitled, ” I Know You are a Chemist But What Do You Do?”

The day commenced with the students being introduced to the scientists that they would later interact with at the informal conversation stations. Dr. Bassam Shakhashiri’s lecture demonstration captivated the students. He began his lecture with a slide show introducing them to a variety of local chemists involved with National Chemistry Week events. The remaining time was spent interactively discussing a variety of demos. A favorite amongst the students was the Briggs-Rauscher oscillating clock reaction in which Dr. Shakhashiri kept asking them if he should look now.

Next, the students proceeded to the Blue Wing in the lower level of the museum. Ten scientists representing nine different organizations were arranged around the room and were available for a two-hour time period. The scientists were:

Marta Biarnes – a former cosmetic chemist from L’Oreal USA, now a member of the MoS staff Jennifer Chute – Criminalist, Boston Police Department Crime Lab Raksmey Derival – Program Manager, Beyond Benign Pamela Hatchfield –Head of Objects Conservation, Museum of Fine Arts, Boston Peter Jepson – Materials Scientist, H.C. Starck Christian Krahforst – Staff Scientist, Massachusetts Bays National Estuary Program Mimi Leveque – Art Conservator, Peabody Essex Museum Jacqueline Massua – Forensic Laboratory Technician, Boston Police Department Crime Lab James Waters – Technical Support, Waters Corporation Bassam Shakhashiri – Professor of Chemistry, University of Wisconsin-Madison

Each scientist was asked to bring a small hands-on activity or demonstration to show the students to encourage conversation. Some examples included bringing samples of different metals for students to look at, preparing a cosmetic, preparing a faience mixture, and performing a fingerprinting activity.

210

Students were provided with biographical sketches of the scientists several days prior to the event to adequately prepare them for the day as students had the option to “interview a scientist” and submit the interviews for potential publication in the local section newsletter, The Nucleus.

In addition to the scientists, four Emmanuel College chemistry majors were present to assist the students with two hands-on activities having a nutrition-based focus. These activities were: Determining the Sugar Content in Cereals and Beverages and Isolating Iron from Total Cereal. Students were amazed by the amount of sugar in a 16 oz can of coke or in a serving of frosted cheerios.

On average students visited three or four scientist stations that were of interest as well as the demonstration stations. Students then had time to tour the museum.

Finally, once the students had finished visiting the scientists, there was still time remaining so we opened up the “conversation stations” to the museum visitors. Many other school groups had the opportunity to talk to the scientists so our reach was even broader than initially anticipated.

This event warrants consideration for the event for a specific audience for the following reasons: 1. The event was tailored for high school students specifically. 2. The section followed the theme of “The Many Faces of Chemistry” and had a wide range of scientists present. 3. Each scientist brought engaging concrete examples of what they do at work on a daily basis to excite the students. 4. The 225 students were from a number of different communities and regions – eastern MA, RI, and western MA.

Part C: Provide a 2-3 sentence (about 50 words) abstract describing the activity/event.

On October 22, 2007, a diverse audience of approximately 225 high school students attended a daylong event entitled “Introducing Students to the Many Faces of Chemistry: at the Museum of Science-Boston. The students participated in the following: 1. watched a lecture-demonstration given by Dr. Bassam Shakhashiri; 2. participated in informal conversation stations with scientists from the Boston Crime Lab, local art museums, local industries such as Waters Corporation, and non-profit organizations such as Beyond Benign and Massachusetss Bay National Estuary Program; 3. participate in hands-on activities celebrating twenty years of NCW; 4. tour the Museum of Science.

Part D: Please provide a 2-3 photographs (digital preferred) that shows the activity/event in action. Photos for winning local sections will be displayed as part of the ChemLuminary Awards audio-visual production.

211

Student interviewing Dr. Bassam Shakhashiri

Overhead view of the Monday program in action.

212

ChemLuminary Award Nomination - 7

Local Section: Northeastern

Award Category: Society Committee on Education Awards: High School Event (s) and Outstanding High School Student Program Award

Contact Person: Name Mukund S Chorghade

Address THINQ Pharma, 14 Carlson Circle, Natick, MA 01760-4205

Phone 508-651-7809

Fax 508-651-7920

E-mail [email protected]

Description of Activity/Program: Please provide a synopsis of the activity/program and state clearly, in 1,000 words or less, why the activity/program merits consideration for this particular award. Only activities/programs that were held in 2007 are eligible for consideration. You may wish to include the following in your description: Name of Activity/Program; Date Conducted; Site/Location; Number of Participants. Please refer to the specific guidelines for each award. Descriptions are limited to 1,000 words or less.

We embarked on a mission to revitalize the speaker’s bureau. We assembled the best talent in our section and have got a list of refined presentations of broad general interest. We have circulated this list to many schools and community organizations.

A major event that we organized was a “Science-Café” in collaboration with Professor Kathi Browne of Natick High School: we organized this two-hour “in-house field trip for 150 of the best students at Natick high and also for some faculty colleagues.

The program, on October 26 was as follows:

1) Kathi Browne: General introduction 2) Steve Lantos: Ashdown and other scholarship exams, Chemistry Olympiad 3) Mukund Chorghade: The use of chemistry, setting up a Science Club 4) Dan Eustace: Show and Tells regarding the excitement of chemistry and Science 5) John Amedio: Careers, internships etc

Based on the feedback received, the speakers were well appreciated. Students are interested in internships and hearing about additional career opportunities in science. Some have also expressed an interest in joining a science club and in taking part in the various science competitions. Two of the biology teachers present at the assembly asked about the possibility of arranging another assembly where we bring in speakers from the biotech industry. We were able to organize this second event and have Dr. David Pizzi, Sr. Director, Shire Therapeutics and his colleagues visit the school for individual classroom discussions and Q & A.

213

A delightful spin-off of this event was the organization of a Science Club at Natick High School for helping the students of NHS in promoting the study of science. Kathy Brown of Natick High School was successful in securing a NSF grant to obtain materials to organize a science club, the goal being to encourage students to participate in and compete in local science competitions such as the Science Bowl and the Women in Science Competition. Our local section helped organize this and provided adult support. The school now has a time and location where students can compete in a friendly sort of way and learn additional science concepts as they do.

We were able to help Amrita Karambelkar secure an internship at Tufts Medical School. She was very excited about this, did a project and is now a co-author of a published paper. She was the first high school senior (accepted at Harvard and MIT) to write a special article for the Nucleus.

Education events at area high schools organized by Ruth Tanner and Steve Lantos were superb and are the pride and joy of the section. The 2007 Connections to Chemistry program was held at Burlington High School with 112 High School Chemistry teachers from 72 schools from Massachusetts, Maine, New Hampshire and Connecticut. Each received the October issue of the Journal of Chemical Education with a username and password for temporary full access to JCE Online (October 17 – November 17, 2007) and a copy of a recent issue of C&EN. In addition, each participant received a year’s subscription to ChemMatters, and a certificate for three hours of Professional Development. Five workshops were offered: each teacher participated in two of them. Mukund Chorghade presented a workshop on Careers in Chemistry. Terri Taylor presented a workshop at the program on the high school chemistry initiative by the ACS.

Abstract: A major event that we organized was a “Science-Café” in collaboration with Professor Kathi Browne of Natick High School: we organized this two-hour “in-house field trip for 150 of the best students at Natick high and also for some faculty colleagues. Several bioterch industry executives discussed career opportunities in Chemistry. We were able to organize a second event and have Dr. David Pizzi, Sr. Director, Shire Therapeutics and his colleagues visit the school for individual classroom discussions and Q & A.

A delightful spin-off of this event was the organization of a Science Club at Natick High School. for helping the students of NHS in promoting the study of science. We were able to help Amrita Karambelkar secure an internship at Tufts Medical School. She was very excited about this, did a project and is now a co-author of a published paper. She was the first high school senior (accepted at Harvard and MIT) to write a special article for the Nucleus.

214