Profiles, Pathways and Dreams: from Naïveté to the Hist Award
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Cell Circuitry || Science Teaches English || The Chicken Genome Is Hot || Magnets in Medicine SEPTEMBER 2002 www.hhmi.org/bulletin Leading Doublea Life It’s a stretch, but doctors who work bench to bedside say they wouldn’t do it any other way. FEATURES 14 On Human Terms 24 The Evolutionary War A small—some say too small—group of Efforts to undermine evolution education have physician-scientists believes the best science evolved into a 21st-century marketing cam- requires patient contact. paign that relies on legal acumen, manipulation By Marlene Cimons of scientific literature and grassroots tactics. 20 Engineering the Cell By Trisha Gura Adam Arkin sees the cell as a mechanical system. He hopes to transform molecular 28 Call of the Wild biology into a kind of cellular engineering Could quirky, new animal models help scien- and in the process, learn how to move cells tists learn how to regenerate human limbs or from sickness to health. avert the debilitating effects of a stroke? By M. Mitchell Waldrop By Kathryn Brown 24 In front of a crowd of 1,500, Ohio’s Board of Education heard testimony on whether students should learn about intelligent design in science class. DEPARTMENTS 2 NOTA BENE 33 PERSPECTIVE ulletin Intelligent Design Is a Cop-Out 4 LETTERS September 2002 || Volume 15 Number 3 NEWS AND NOTES HHMI TRUSTEES PRESIDENT’S LETTER 5 JAMES A. BAKER, III, ESQ. 34 Senior Partner, Baker & Botts A Creative Influence In from the Fields ALEXANDER G. BEARN, M.D. Executive Officer, American Philosophical Society 35 Lost on the Tip of the Tongue Adjunct Professor, The Rockefeller University UP FRONT Professor Emeritus of Medicine, Cornell University Medical College 36 Biology by Numbers FRANK WILLIAM GAY 6 Follow the Songbird Former President and Chief Executive Officer, SUMMA Corporation JAMES H. -
Non-Traditional Hydrogen Bond Explanation of Asymmetric Catalysis of Mukaiyama Aldol Reactions by Dinuclear Zinc Semi- Crown Ligands
Duquesne University Duquesne Scholarship Collection Undergraduate Research and Scholarship Symposium 2016-04-06 Non-traditional hydrogen bond explanation of asymmetric catalysis of Mukaiyama aldol reactions by dinuclear zinc semi- crown ligands Ayan N. Ahmed Duquesne University Brandon Vernier Duquesne University Jeffrey Rohde Franciscan University of Steubenville Jeffrey D. Evanseck Duquesne University Follow this and additional works at: https://dsc.duq.edu/urss Part of the Chemistry Commons Non-traditional hydrogen bond explanation of asymmetric catalysis of Mukaiyama aldol reactions by dinuclear zinc semi-crown ligands. (2016). Retrieved from https://dsc.duq.edu/urss/2016/proceedings/2 This Paper is brought to you for free and open access by Duquesne Scholarship Collection. It has been accepted for inclusion in Undergraduate Research and Scholarship Symposium by an authorized administrator of Duquesne Scholarship Collection. Non-traditional hydrogen bond explanation of asymmetric catalysis of Mukaiyama aldol reactions by dinuclear zinc semi-crown ligands Ayan N. Ahmed, Brandon Vernier, Jeffrey Rohde, and Jeffrey D. Evanseck Bayer School of Natural and Environmental Sciences Faculty Advisor: Jeffrey Evanseck, Ph.D. Introduction The Pollution Prevention Act of 1990 put green chemistry at the forefront of chemical design and synthesis to ensure the sanctity and sustainability of the environment.1 Yet, a majority of catalysts employed today are metal based and continue to be dangerously toxic. Consequently, the dream of green chemistry is far from reaching its full potential. Our work on metal free catalysis is to first understand the mechanistic and electronic control of metals in catalysis. The foundation of our work has been possible through combining the advances of two renown scientists: E. -
Alumni Newsletter
ALUMNI NEWSLETTER lr II SCHOOL OF CHEMICAL SCIENCES I! UNIVERSITY OF ILLINOIS at Urbana-Champaign NO. 7, WINTER 1972-73 A Busy Week in June Seldom have so many worthy events been crowded into one week as have graced the people of the School of Chemical Sciences this June 9-15, 1972. Dr. H. E. Carter's portrait was hung in the Chemistry Library along with those of Parr, Noyes, and Adams; Dr. Philip Handler was honored at com mencement as a Distinguished Alumnus of the University; East Chemistry was dedicated as the Roger Adams Laboratory; and Alpha Chi Sigma held its Biennial National Conclave on our campus. Individually and in com bination these celebrations brought together in Urbana students, faculty, former faculty, alumni, distinguished guests, family, and friends from far corners. Roger Adams Laboratory Dedicated Several years ago, the Board of Trustees of the University ruled that campus buildings should have names that describe their function rather than names commemorating influential University people. Fortunately, however, the board modified this rule for a very special occasion last summer, and autho rized the changing of the name of East Chemistry Building to the Roger Adams Laboratory. The building was dedicated with this new name on Sun day, June 11, as the opening event of the Biennial National Conclave of the professional chemistry fraternity, Alpha Chi Sigma. Professor Gutowsky presided at the ceremony, introducing first Dr. J. W. Peltason, Chancellor of the Upiversity of Illinois at Urbana-Champaign, who paid tribute to Professor Adams and his work. Dr. Ernest Volwiler (Ph.D. -
The Nakanishi Symposium on Natural Products & Bioorganic Chemistry
The Nakanishi Symposium on Natural Products & Bioorganic Chemistry March 19, 2021 Sponsored by The Chemical Society of Japan & The American Chemical Society ー1ー Yoshito Kishi Professor Emeritus, Harvard University ■EDUCATION Bachelor of Science, Nagoya University 1961 Doctor of Philosophy (Chemistry), Nagoya University (Professors Yoshimasa Hirata and Toshio Goto) 1966 Postdoctoral Research Fellow (Chemistry), Harvard University (Professor R. B. Woodward) 1966-1968 ■ACADEMIC APPOINTMENT Instructor of Chemistry, Nagoya University 1966-1970 Associate Professor of Agricultural Chemistry, Nagoya University 1970-1974 Visiting Professor of Chemistry, Harvard University 1972-1973 Professor of Chemistry, Harvard University 1974-1982 Morris Loeb Professor of Chemistry, Harvard University 1982-2002 Morris Loeb Professor of Chemistry, Emeritus, Harvard University 2002- ー2ー ■RESEARCH TOPICS (chronological order) 1. Chemical studies of bioluminescence: The luminescent substance named luciferin is an unstable compound, making its structural determination extremely difficult. Dr. Kishi, however, determined the structures of luciferins, such as those in Cypridina, Genji fireflies, krill, dinoflagellates, and the luminous shellfish of Latia (1960s–1980s). 2. Total synthesis of complex natural products: The pufferfish toxin tetrodotoxin, the structure of which was determined in 1964, is still known as one of the most difficult natural products to synthesize due to its highly functionalized structural complexity. Dr. Kishi achieved the world’s first total synthesis of this compound in 1972. Later, he achieved total synthesis of the paralytic shellfish toxin saxitoxin, the anticancer drug mitomycin C, the fungus toxin sporidesmin, and the β-lactam antibiotics (1970s–1980s). 3. Development of acyclic stereocontrol in total synthesis of natural products: Until the early 1970s, total synthesis of polyether antibiotics was almost impossible due to the presence of numerous asymmetric centers. -
Date: To: September 22, 1 997 Mr Ian Johnston©
22-SEP-1997 16:36 NOBELSTIFTELSEN 4& 8 6603847 SID 01 NOBELSTIFTELSEN The Nobel Foundation TELEFAX Date: September 22, 1 997 To: Mr Ian Johnston© Company: Executive Office of the Secretary-General Fax no: 0091-2129633511 From: The Nobel Foundation Total number of pages: olO MESSAGE DearMrJohnstone, With reference to your fax and to our telephone conversation, I am enclosing the address list of all Nobel Prize laureates. Yours sincerely, Ingr BergstrSm Mailing address: Bos StU S-102 45 Stockholm. Sweden Strat itddrtSMi Suircfatan 14 Teleptelrtts: (-MB S) 663 » 20 Fsuc (*-«>!) «W Jg 47 22-SEP-1997 16:36 NOBELSTIFTELSEN 46 B S603847 SID 02 22-SEP-1997 16:35 NOBELSTIFTELSEN 46 8 6603847 SID 03 Professor Willis E, Lamb Jr Prof. Aleksandre M. Prokhorov Dr. Leo EsaJki 848 North Norris Avenue Russian Academy of Sciences University of Tsukuba TUCSON, AZ 857 19 Leninskii Prospect 14 Tsukuba USA MSOCOWV71 Ibaraki Ru s s I a 305 Japan 59* c>io Dr. Tsung Dao Lee Professor Hans A. Bethe Professor Antony Hewlsh Department of Physics Cornell University Cavendish Laboratory Columbia University ITHACA, NY 14853 University of Cambridge 538 West I20th Street USA CAMBRIDGE CB3 OHE NEW YORK, NY 10027 England USA S96 014 S ' Dr. Chen Ning Yang Professor Murray Gell-Mann ^ Professor Aage Bohr The Institute for Department of Physics Niels Bohr Institutet Theoretical Physics California Institute of Technology Blegdamsvej 17 State University of New York PASADENA, CA91125 DK-2100 KOPENHAMN 0 STONY BROOK, NY 11794 USA D anni ark USA 595 600 613 Professor Owen Chamberlain Professor Louis Neel ' Professor Ben Mottelson 6068 Margarldo Drive Membre de rinstitute Nordita OAKLAND, CA 946 IS 15 Rue Marcel-Allegot Blegdamsvej 17 USA F-92190 MEUDON-BELLEVUE DK-2100 KOPENHAMN 0 Frankrike D an m ar k 599 615 Professor Donald A. -
Melvin Calvin
M ELVIN C A L V I N The path of carbon in photosynthesis Nobel Lecture, December 11, 1961 Introduction It is almost sixty years since Emil Fischer was describing on a platform such as this one, some of the work which led to the basic knowledge of the struc- ture of glucose and its relatives 1 . Today we will be concerned with a de- scription of the experiments which have led to a knowledge of the principal reactions by which those carbohydrate structures are created by photo- synthetic organisms from carbon dioxide and water, using the energy of light. The speculations on the way in which carbohydrate was built from carbon dioxide began not long after the recognition of the basic reaction and were carried forward first by Justus von Liebig and then by Adolf von Baeyer and, finally, by Richard Willstätter and Arthur Stall into this century. Actually, the route by which animal organisms performed the reverse reaction, that is, the combustion of carbohydrate to carbon dioxide and water with the utili- zation of the energy resulting from this combination, turned out to be the first one to be successfully mapped, primarily by Otto Meyerhof 2 and Hans Krebs 3. Our own interest in the basic process of solar energy conversion by green plants, which is represented by the overall reaction began some time in the years between 1935 and 1937, during my post- doctoral studies with Professor Michael Polanyi at Manchester. It was there I first became conscious of the remarkable properties of coordinated metal compounds, particularly metalloporphyrins as represented by heme and chlorophyll. -
Cv Mlhg 2015
CURRICULUM VITAE Name: GREEN, Malcolm Leslie Hodder Address: St Catherine's College, Oxford or Inorganic Chemistry Laboratory South Parks Road OXFORD, OX1 3QR Date of Birth: 16/4/36, Eastleigh, Hampshire Nationality: British Marital Status: Married. Three children Degrees: B.Sc.(Hons), London; D.I.C., M.A.(Cantab), M.A.(Oxon), C.Chem., F.R.S.C., Ph.D., F.R.S. ACADEMIC CAREER 1953-56 Acton Technical College, University of London, B.Sc Hons. Chemistry 1956-59 Imperial College of Science and Technology, London; D.I.C. Ph.D. in chemistry. Supervisor Professor Sir G. Wilkinson 1959-60 Post-doctoral Research Associates Fellow. Imperial College of Science and Technology 1960-63 Assistant Lecturer in Inorganic Chemistry at Cambridge University 1961 Fellow of Corpus Christi College, Cambridge 1963 Sepcentenary Fellow of Inorganic Chemistry, Balliol College, Oxford and Departmental Demonstrator, University of Oxford 1965 University Lecturer, University of Oxford 1971 Visiting Professor, University of Western Ontario (Spring Term) 1972 Visiting Professor, Ecole de Chimie and Institute des Substances Naturelles, Paris (six months) 1973 A.P. Sloan Visiting Professor, Harvard University, (Spring Semester) 1979-84 Appointed to the British Gas Royal Society Senior Research Fellowship 1981 Sherman Fairchild Visiting Scholar at the California Institute of Technology(4 months) 1984 Re-appointed British Gas Royal Society Senior Research Fellow (1984-6) 1987 Vice-master, Balliol College, Oxford (T.T.) 1989 Appointed Professor of Inorganic Chemistry and Head of Department, Oxford University Fellow of St Catherine's College, Oxford 2004- present Emeritus Research Professor in the Inorganic Chemistry Laboratory, Oxford University Emeritus Fellow of Balliol College and St Catherine’s College Publications Two text books, 646 refereed papers and 8 patents. -
Documenting the Biotechnology Industry in the San Francisco Bay Area
Documenting the Biotechnology Industry In the San Francisco Bay Area Robin L. Chandler Head, Archives and Special Collections UCSF Library and Center for Knowledge Management 1997 1 Table of Contents Project Goals……………………………………………………………………….p. 3 Participants Interviewed………………………………………………………….p. 4 I. Documenting Biotechnology in the San Francisco Bay Area……………..p. 5 The Emergence of An Industry Developments at the University of California since the mid-1970s Developments in Biotech Companies since mid-1970s Collaborations between Universities and Biotech Companies University Training Programs Preparing Students for Careers in the Biotechnology Industry II. Appraisal Guidelines for Records Generated by Scientists in the University and the Biotechnology Industry………………………. p. 33 Why Preserve the Records of Biotechnology? Research Records to Preserve Records Management at the University of California Records Keeping at Biotech Companies III. Collecting and Preserving Records in Biotechnology…………………….p. 48 Potential Users of Biotechnology Archives Approaches to Documenting the Field of Biotechnology Project Recommendations 2 Project Goals The University of California, San Francisco (UCSF) Library & Center for Knowledge Management and the Bancroft Library at the University of California, Berkeley (UCB) are collaborating in a year-long project beginning in December 1996 to document the impact of biotechnology in the Bay Area. The collaborative effort is focused upon the development of an archival collecting model for the field of biotechnology to acquire original papers, manuscripts and records from selected individuals, organizations and corporations as well as coordinating with the effort to capture oral history interviews with many biotechnology pioneers. This project combines the strengths of the existing UCSF Biotechnology Archives and the UCB Program in the History of the Biological Sciences and Biotechnology and will contribute to an overall picture of the growth and impact of biotechnology in the Bay Area. -
THE NINETY-THIRD PRESENTATION of the WILLARD GIBBS MEDAL (Founded by William A
http:/chicagoacs.org MAY• 2004 THE NINETY-THIRD PRESENTATION OF THE WILLARD GIBBS MEDAL (Founded by William A. Converse) to PROFESSOR RONALD BRESLOW sponsored by the CHICAGO SECTION AMERICAN CHEMICAL SOCIETY FRIDAY, MAY 21, 2004 North Shore Lights at The iation for a nametag , and your check. Acceptance of the Award Hotel Moraine Be sure to include your address. 700 North Sheridan Road Tables fo r ten are availab le. If you Highwood, Illinois would like a table for a group, please 847-433-6366 put the ir names on a separate sheet and include it with your registration. DIRECTIONS TO THE MEETING From the North or South: Take 1-294 (continued on page 2) (the TriState Tollway) to Route 22. Exit east, take it to Route 41 (Skokie Hwy). AWARD CEREMONY 8:30 P.M. Turn north to the next exit, Old Elm. Go east on Old Elm to Sheridan Road Oust The Willard Gibbs Medal across some railroad tracks) . Turn right/south for 3/4 mile. The hotel is on Milt Levenberg, Chair the right. Chicago Section, ACS From Downtown: Take the Kennedy Introduction of the Medalist Expressway north. At the split , follow the Edens Expressway , which turns Madeleine Jacobs Executive Director & CEO, ACS into Skokie Highway past Lake Cook Dr. Ronald Breslow Road. Continue north to Old Elm Road. Presentation of the Medal Samuel Latham Mitchill Professor of Turn right/east on Old Elm and follow Chemistry and University Professor the directions above to the hotel. Dr. Charles P. Casey Department of Chemistry President, ACS Columbia University Parking: Free New York, NY RECEPTION 6:00-7:00 P.M. -
THE 101ST PRESENTATION of the WILLARD GIBBS MEDAL (Founded by William A
Chicago Section http://chicagoacs.org MARCH • 2012 THE 101ST PRESENTATION OF THE WILLARD GIBBS MEDAL (Founded by William A. Converse) to PROFESSOR MARK A. RATNER sponsored by the CHICAGO SECTION AMERICAN CHEMCIAL SOCIETY FRIDAY, MAY 18, 2012 Casa Royale Seating will be available after the dinner 783 Lee Street for people not attending the dinner but Des Plaines, IL 60016 interested in hearing the speaker. 847-297-6640 (continued on page 2) Directions to Casa Royale are on page 2. AWARD CEREMONY 8:30 PM RECEPTION 6:00 P.M. Hors-d’oeuvres The Willard Gibbs Medal Two Complimentary Drinks Avrom C. Litin, Chair DINNER 7:00 P.M. Chicago Section, ACS The History of the Willard Gibbs Award Dinner reservations are required. To re- serve your tickets, please call the Chi- Introduction of the Medalist cago Section office at 847-391-9091 or register at http://ChicagoACS.org by Presentation of the Medal Monday, May 14 and pay $40 at the door, or fill out the reservation form on The Citation: Dr. Mark A. Ratner, Dumas University page 5 and mail it with your payment of Professor, Department of Chemistry, $40 by Wednesday, May 9 to the ad- For principal achievements in Northwestern University, Evanston, IL dress given on the form. If you are not • Molecular Electronics a member of the Chicago Local Section, ACCEPTANCE ADDRESS you are not eligible for half price tick- • Single-Molecule Aspects of Molecu- ets for students, unemployed, or retired lar Electronics “From Rectifying to Energy: Some Chicago Section members. Tickets and Reflections” nametags will be available at the door. -
And Silane- Controlled Enantioselective Hydrofunctionali- Zation of Alkenes by TM-HAT and RPC Mechanism
1Catalyst- and silane- controlled Enantioselective Hydrofunctionali- zation of Alkenes by TM-HAT and RPC mechanism Kousuke Ebisawa, Kana Izumi, Yuka Ooka, Hiroaki Kato, Sayori Kanazawa, Sayura Komatsu, Eriko Nishi, Kou Hiroya, and Hiroki Shigehisa* Faculty of Pharmacy, Musashino University, 1-1-20 Shinmachi Nishitokyo-shi, Tokyo 202-8585, Japan Supporting Information Placeholder ABSTRACT: The catalytic enantioselective synthesis of tetrahy- However, there is significant room for improvement in the sub- drofurans, found in the structures of many biologically active strate scope and yield. Lin also recently reported the enantioselec- natural products, via a transition-metal-catalyzed hydrogen atom tive hydrocyanation of conjugated alkenes by dual electrocatalysis transfer (TM-HAT) and radical-polar crossover (RPC) mechanism that include a HAT mechanism.8 is described. Hydroalkoxylation of non-conjugated alkenes pro- ceeded efficiently with excellent enantioselectivity (up to 97:3 er) using a suitable chiral cobalt catalyst, N-fluoro-2,4,6- trimethylpyridinium tetrafluoroborate, and a diethylsilane. Sur- prisingly, absolute configuration of the product was highly de- pendent on the bulkiness of the silane. Mechanistic studies sug- gested a HAT mechanism and multiple enantiodetermining steps via an organocobalt(III) intermediate. DFT calculations suggested the presence of a cationic organocobalt intermediate, and that a critical factor of the enantioselectivity is the thermodynamic sta- bility of the organocobalt(III) intermediate. Transition-metal-catalyzed hydrogen atom transfer (TM-HAT) to alkenes has recently attracted significant attention in synthetic organic chemistry.2 Since Mukaiyama and Isayama reported the Figure 1. Achiral and chiral hydrofunctionalization of alkenes via catalytic hydration of alkenes under aerobic conditions,3 the al- TM-HAT. -
Chicago Section American Chemical
OCTOBER • 2007 CHICAGO SECTION AMERICAN CHEMICAL SOCIETY Joint Meeting of Northwester Unversity Department of Chemistry and the Chicago Section ACS Basolo Medal Award Lecture, Dinner and Presentation FRIDAY, OCTOBER 19, 2007 BASOLO MEDAL LECTURE 2007 Fred Basolo Medalist Dinner Location: Northwestern University Technological Institute Zhivago Restaurant & Banquets 2145 Sheridan Road 9925 Gross Point Road Evanston, IL Skokie, IL Lecture Room 3 847-982-1400 DIRECTIONS TO THE TECH DIRECTIONS TO THE RESTAU- INSTITUTE: RANT:From the Tech Institute in Evanston: Go North on Sheridan Rd. From the city: Take Lake Shore Drive and turn left on Central St. Turn left on North to Sheridan Road into Evanston. Gross Point Rd. and proceed to the Continue on Sheridan Road to the Tech restaurant. Institute at Noyes Street. From Edens Expressway: Take From the west: Take I-88 east to 294 Dempster east to Gross Point Rd. Turn north to Dempster east. Proceed east on left on Gross Point Rd. and proceed to Dempster into Evanston. Turn left onto the restaurant. Chicago Ave. and proceed to Sheridan Dr. Richard R. Schrock, Frederick G. Road. Take Sheridan Road north to the Keyes, Professor of Chemistry, Mas- (FOR DETAILS, SEE SECTION'S Tech Institute. The Technological Insti- sachusetts Institute of Technology WEBSITE) tute is at the intersection of Sheridan Road and Noyes Street in Evanston. Title: "Catalytic Reduction of Dinitro- PARKING: Free in the lot. Parking is gen to Ammonia at Room Tempera- also available at Keeler Avenue and To those attending the Basolo Medal lec- ture and One Atmosphere with Pro- Gross Point Road.