Adrenergic Receptor Beta Receptor

Adrenergic receptors are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine and epinephrine. Many cells possess these receptors, and the binding of a catecholamine to the receptor will generally stimulate the sympathetic nervous system. The sympathetic nervous system is responsible for the fight-or-flight response, which includes widening the pupils of the eye, mobilizing energy, and diverting blood flow from non-essential organs to skeletal muscle. There are two main groups of adrenergic receptors, α and β, with several subtypes. α receptors have the subtypes α1 and α2. β receptors have the subtypes β1, β2 and β3. All three are linked to Gs proteins, which in turn are linked to adenylate cyclase. Agonist binding thus causes a rise in the intracellular concentration of the second messenger cAMP. Downstream effectors of cAMP include cAMP-dependent protein kinase (PKA), which mediates some of the intracellular events following hormone binding.

www.MedChemExpress.com 1 Adrenergic Receptor Antagonists, Agonists, Inhibitors, Activators & Modulators

(+)-Penbutolol (4E)-SUN9221 ((R)-Penbutolol; (+)-Isopenbutolol) Cat. No.: HY-116790A Cat. No.: HY-U00367

(+)-Penbutolol is a β-adrenoceptor antagonist, (4E)-SUN9221 is a potent antagonist of

with an IC50 of 0.74 μM. (+)-Penbutolol is an α1-adrenergic receptor and 5-HT2 receptor, with optical isomer of l-penbutolol with Na+ antihypertensive and anti-platelet aggregation channel-blocking action. activities.

Purity: ≥95.0% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

(R)-(+)-Atenolol (R)-Carvedilol Cat. No.: HY-B2111 ((R)-BM 14190) Cat. No.: HY-B0006C

(R)-(+)-Atenolol is the less active enantiomer of (R)-Carvedilol ((R)-BM 14190), the R-enantiomer of the (R,S)-atenolol. (R,S)-atenolol is a Carvedilol, is a non-selective β/α-1 blocker. β-adrenergic receptor antagonist. (R)-Carvedilol exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).

Purity: ≥99.0% Purity: 99.05% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 5 mg, 10 mg

(R)-Propranolol hydrochloride (R)-Terazosin Cat. No.: HY-A0295 Cat. No.: HY-B0371B

(R)-Propranolol hydrochloride is a less active (R)-Terazosin is an active R-enantiomer of enantiomer of the β-adrenoceptor Terazosin. (R)-Terazosin is a potent

antagonist propranolol (HY-B0573). α1-adrenoceptor antagonist with Ki values of 6.51 nM, 1.01 nM and 1.97 nM for α1a, α1b and α1d-adrenoceptor, respectively.

Purity: >98% Purity: 99.77% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

(Rac)-Rotigotine hydrochloride (RS)-Butyryltimolol Cat. No.: HY-15394 Cat. No.: HY-102032A

(Rac)-Rotigotine hydrochloride is a racemate of (RS)-Butyryltimolol is the racemate of Rotigotine. Butyryltimolol. Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol. Butyryltimolol is a β-adrenergic blocker.

Purity: 97.76% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

(S)-(-)-Propranolol hydrochloride (S)-Carvedilol Cat. No.: HY-B0573A ((S)-BM 14190) Cat. No.: HY-B0006B

(S)-(-)-Propranolol hydrochloride is a β-adrenergic (S)-Carvedilol, the S-enantiomer of Carvedilol, is

receptor antagonist with log Kd values of a non-selective β/α-1 blocker. (S)-Carvedilol

-8.16, -9.08, and -6.93 for β1, β2, and β3, exerts protection against the vascular or cardiac respectively. toxicity of Doxorubicin (DOX).

Purity: ≥97.0% Purity: 99.25% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, Size: 5 mg, 10 mg

2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

(S)-Terazosin (S)-Timolol Maleate Cat. No.: HY-B0371D (L-714,465 Maleate; MK 950) Cat. No.: HY-17380

(S)-Terazosin is an active S-enantiomer of (S)-Timolol Maleate (L-714,465 Maleate) is a Terazosin. (S)-Terazosin is a potent and non-cardioselective hydrophilic β-adrenoceptor high-affinity α-adrenoceptor antagonist with Ki blocker. (S)-Timolol Maleate is widely used as values of 3.91 nM, 0.79 nM and 1.16 nM for α1a, standard medication for intraocular pressure α1b and α1d-adrenoceptor, respectively. (glaucoma) by preventing the production of aqueous humor. Purity: 99.77% Purity: 99.85% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 100 mg, 200 mg

(±)-Befunolol (±)-Bisoprolol hemifumarate Cat. No.: HY-101752 (Bisoprolol hemifumarate salt) Cat. No.: HY-B0076

(±)-Befunolol is a β-adrenoceptor blocking agent. (±)-Bisoprolol (hemifumarate) is a selective type β1 adrenergic receptor blocker. Target: Adrenergic Receptor Approved: July 31, 1992 Bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage.

Purity: >98% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg

2',5'-Dideoxyadenosine 4-Hydroxypropranolol D7 hydrochloride Cat. No.: HY-135878 ((±)-4-hydroxy Propranolol D7 hydrochloride) Cat. No.: HY-100634S

2',5'-Dideoxyadenosine is a potent and 4-Hydroxypropranolol D7 hydrochloride non-competitive adenylyl cyclase inhibitor via ((±)-4-hydroxy Propranolol D7 hydrochloride) is a binding the P-site with an IC50 of 3 µM . deuterium labeled 4-Hydroxypropranolol 2',5'-Dideoxyadenosine is a nucleoside analog and hydrochloride. exerts a potent antiadrenergic action in heart.

Purity: 99.86% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg, 250 mg Size: 1 mg, 5 mg

4-Hydroxypropranolol hydrochloride 5-HT2 antagonist 1 ((±)-4-hydroxy Propranolol hydrochloride) Cat. No.: HY-100634 Cat. No.: HY-U00365

4-Hydroxypropranolol hydrochlorid is an active 5-HT2 antagonist 1 is a potent antagonist of metabolite of Propranolol. 4-Hydroxypropranolol 5-HT2 receptor, with weak α1 adrenoceptor hydrochlorid is of comparable potency to blocking activity. Propranolol.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 1 mg, 5 mg

Aaptamine Acebutolol D7 Cat. No.: HY-N4225 Cat. No.: HY-17497S

Aaptamine, a spongean alkaloid isolated from a sea Acebutolol D7 is a deuterium labeled Acebutolol. sponge Aaptos aaptos, is a competitive antagonist Acebutolol is a selective β1 adrenergic receptor of α-adrenoceptor and activates the p21 promoter antagonist used in the treatment of hypertension, in a p53-independent manner. angina pectoris and cardiac arrhythmias.

Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg

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Acebutolol hydrochloride ACTH (1-14) Cat. No.: HY-17497A (Adrenocorticotropic Hormone Fragment 1-14) Cat. No.: HY-P1582

Acebutolol hydrochloride is a β1 adrenergic ACTH (1-14) is a fragment of adrenocorticotrophin, receptor (β1AR) antagonist. Acebutolol which regulates cortisol and androgen production. hydrochloride is used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.

Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 5 g, 10 g Size: 1 mg, 5 mg

ACTH (1-14) (TFA) ADRA1D receptor agonist 1 (Adrenocorticotropic Hormone Fragment 1-14 TFA) Cat. No.: HY-P1582A Cat. No.: HY-135270

ACTH (1-14) (TFA) is a fragment of ADRA1D receptor agonist 1 (compound (R)-9S) is a

adrenocorticotrophin, which regulates cortisol and potent, selective and orally active α1D

androgen production. adrenoceptor antagonist, with a Ki of 1.6 nM.

Purity: 98.55% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg

AGN 192836 Ajmalicine Cat. No.: HY-100300 (Raubasine) Cat. No.: HY-N1919

AGN 192836 is a potent and selective α2 adrenergic Ajmalicine (Raubasine) is found in herbs of

agonist with EC50s of 8.7, 41 and 6.6 nM for Catharanthus roseus, is an antihypertensive drug α2A, α2B and α2C receptor, respectively. used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Alfuzosin Alfuzosin hydrochloride (SL 77499) Cat. No.: HY-B0192 (SL 77499-10) Cat. No.: HY-B0192A

Alfuzosin is an α1 adrenergic receptor antagonist Alfuzosin hydrochloride is an α1 adrenergic used to treat benign prostatic hyperplasia (BPH). receptor antagonist used to treat benign prostatic hyperplasia (BPH).

Purity: 99.67% Purity: 98.73% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Amezinium methylsulfate Amibegron hydrochloride (Amezinium metilsulfate; Lu-1631) Cat. No.: HY-A0275 (SR 58611A) Cat. No.: HY-103207

Amezinium metilsulfate has multiple mechanisms, Amibegron hydrochloride is a selective

including stimulation of alpha and beta-1 β3-adrenoceptor agonist, with an EC50 of 3.5 nM receptors and inhibition ofnoradrenaline and for β-adrenoceptor in rat colon; Amibegron tyramine uptake. hydrochloride has anxiolytic and antidepressant activity.

Purity: 99.51% Purity: ≥99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g Size: 10 mM × 1 mL, 5 mg

4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Amitraz Amitriptyline hydrochloride (BTS-27419) Cat. No.: HY-B1111 Cat. No.: HY-B0527A

Amitraz is a non-systemic acaricide and Amitriptyline hydrochloride is an inhibitor of insecticide, with alpha-adrenergic agonist serotonin reuptake transporter (SERT) and activity, interaction with octopamine receptors of noradrenaline reuptake transporter (NET), with Kis the central nervous system and inhibition of of 3.45 nM and 13.3 nM for human SERT and NET, monoamine oxidases and prostaglandin synthesis. respectively.

Purity: ≥98.0% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Ancarolol AR-08 Cat. No.: HY-100141 Cat. No.: HY-U00371

Ancarolol is a beta-adrenergic blocking agent. AR-​08 is an agonist of α2-adrenergic receptor, used for the treatment of attention deficit hyperactivety disorder (ADHD).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Arbutamine Arotinolol Cat. No.: HY-16056 Cat. No.: HY-122537A

Arbutamine is a short-acting, potent and Arotinolol is a nonselective α/β-adrenergic nonselective β-adrenoceptor agonist that receptor blocker and a vasodilating β-blocker. increases heart rate, cardiac contractility, and Arotinolol also shows potency for inhibiting the systolic blood pressure. Arbutamine is a binding of the radioligand 125I-ICYP to catecholamine for a pharmacological cardiac stress 5HT1B-serotonergic receptor sites. agen. Purity: ≥98.0% Purity: 98.23% Clinical Data: Launched Clinical Data: Launched Size: 1 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg

Asenapine Atenolol (Org 5222) Cat. No.: HY-10121 ((RS)-Atenolol) Cat. No.: HY-17498

Asenapine (Org 5222), an atypical antipsychotic, Atenolol ((RS)-Atenolol) is a cardioselective is an antagonist of serotonin receptors (pKi: β1-adrenergic receptor blocker, with a Ki of 697

8.4-10.5), adrenoceptors (pKi: 8.9-9.5), nM atβ1-adrenoceptor in guine pig left ventricle dopamine receptors (pKi: 8.9-9.4) and membrane. Atenolol can be used for the research of histamine receptors (pKi: 8.2-9.0). hypertension and angina pectoris.

Purity: 98.81% Purity: 99.61% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Atipamezole Atipamezole hydrochloride (MPV 1248) Cat. No.: HY-12380A (MPV-1248 hydrochloride) Cat. No.: HY-12380

Atipamezole (MPV 1248) is a potent Atipamezole (MPV-1248) hydrochloride is a potent

α2-adrenoceptor antagonist with a Ki of 1.6 nM. α2-adrenoceptor antagonist with a Ki of 1.6 nM.

Purity: 99.48% Purity: 99.41% Clinical Data: Phase 1 Clinical Data: Phase 1 Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

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Bambuterol Bambuterol hydrochloride ((±)-Bambuterol; KWD-2183) Cat. No.: HY-17501 ((±)-Bambuterol hydrochloride; KWD-2183 hydrochloride) Cat. No.: HY-17501A

Bambuterol ((±)-Bambuterol; KWD-2183) is a long Bambuterol hydrochloride ((±)-Bambuterol acting beta-adrenoceptor agonist (LABA) used in hydrochloride; KWD-2183 hydrochloride) is a long the treatment of asthma; it also is a prodrug of acting beta-adrenoceptor agonist (LABA) used in terbutaline. the treatment of asthma; it also is a prodrug of terbutaline.

Purity: >98% Purity: 99.64% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Batefenterol Benzquinamide (GSK961081; TD-5959) Cat. No.: HY-12980 (P2647; BZQ; Benzoquinamide) Cat. No.: HY-U00244

Batefenterol (GSK961081;TD-5959) is a novel Benzquinamide (P2647) is an antiemetic which can

muscarinic receptor antagonist and bind to the α2A, α2B, and α2C adrenergic

β2-adrenoceptor agonist; displays high affinity receptors (α2-AR) with Ki values of 1,365, 691,

for hM2, hM3 muscarinic and hβ2-adrenoceptor with and 545 nM, respectively.

Ki values of 1.4, 1.3 and 3.7 nM, respectively.

Purity: 98.17% Purity: >98% Clinical Data: Phase 2 Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Betaxolol Betaxolol hydrochloride Cat. No.: HY-B0381 (SL75212) Cat. No.: HY-B0381A

Betaxolol is a selective beta1 adrenergic Betaxolol Hydrochloride is a selective beta1 receptor blocker that can be used for the adrenergic receptor blocker that can be used for research of hypertension and glaucoma. the research of hypertension and glaucoma.

Purity: 95.06% Purity: 98.69% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Bevantolol hydrochloride BI-167107 Cat. No.: HY-121186 Cat. No.: HY-121251

Bevantolol hydrochloride is a selective β1 and BI-167107 is a high affinity, full agonist that

α1-adrenergic receptor antagonist with pKi values binds to the β2 adrenergic receptor (β2AR) with a

of 7.83, 6.9 in rat cerebral cortex, respectively. dissociation constant Kd of 84 pM. Bevantolol hydrochloride is a potent Ca2+ antagonist.

Purity: ≥98.0% Purity: 99.81% Clinical Data: Launched Clinical Data: Size: 10 mM × 1 mL, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Bisoprolol Blonanserin Cat. No.: HY-129029 (AD-5423) Cat. No.: HY-13575

Bisoprolol is a potent, selective and orally Blonanserin (AD-5423) is a potent and orally

active β1-adrenergic receptor blocker. Bisoprolol active 5-HT2A (Ki=0.812 nM)

has little activity on β2-receptor and has the and dopamine D2 receptor (Ki potential for hypertension, coronary artery =0.142 nM) antagonist. disease and stable ventricular dysfunction research. Purity: >98% Purity: 99.77% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 25 mg, 100 mg

6 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Bometolol Hydrochloride Brimonidine Cat. No.: HY-U00386 (UK 14304; AGN190342) Cat. No.: HY-B0659

Bometolol Hydrochloride is a beta-adrenergic Brimonidine (UK 14304) is a full α2-adrenergic blocking agent, used for the research of receptor (α2-AR) agonist. cardiovascular disease.

Purity: >98% Purity: 99.65% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Brimonidine tartrate BRL 37344 sodium (UK 14304 tartrate; AGN190342 tartrate) Cat. No.: HY-B0659A (BRL 37344A) Cat. No.: HY-101325

Brimonidine tartrate (UK 14304 tartrate) is a full BRL 37344 sodium (BRL 37344A) is a specific α2-adrenergic receptor (α2-AR) agonist. β3-adrenergic receptor agonist. BRL 37344 sodium treatment significantly lowers the body weight of obese mice.

Purity: 99.19% Purity: ≥99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg

Brombuterol D9 Brombuterol D9 hydrochloride (Bromobuterol D9) Cat. No.: HY-131104S (Bromobuterol D9 hydrochloride) Cat. No.: HY-131104AS

Brombuterol D9 (Bromobuterol D9) is a deuterium Brombuterol D9 hydrochloride (Bromobuterol D9 labeled Brombuterol. Brombuterol is a β-adrenergic hydrochloride) is a deuterium labeled Brombuterol receptor agonist. hydrochloride. Brombuterol hydrochloride is a β-adrenergic receptor agonist.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Brombuterol hydrochloride Bromchlorbuterol hydrochloride (Bromobuterol hydrochloride) Cat. No.: HY-131145 Cat. No.: HY-136449

Brombuterol hydrochloride (Bromobuterol Bromchlorbuterol hydrochloride is an active hydrochloride) is a β-adrenergic receptor agonist. β-adrenergic agonist (β-agonist) and can be used for the research of pulmonary disease and asthma.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Bucindolol Bufuralol hydrochloride Cat. No.: HY-103214 (Ro 3-4787 hydrochloride) Cat. No.: HY-105124A

Bucindolol is a β1-adrenergic receptor blocker, Bufuralol hydrochloride (Ro 3-4787 hydrochloride) with intrinsic sympathomimetic activity, used in is a potent non-selective, orally active the research of heart failure. β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.

Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg Size: 5 mg

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Carteolol hydrochloride Carvedilol (OPC-1085 hydrochloride) Cat. No.: HY-17495A (BM 14190) Cat. No.: HY-B0006

Carteolol hydrochloride (OPC-1085 hydrochloride) Carvedilol (BM 14190) is a non-selective β/α-1 is a non-selective beta blocker used to treat blocker. Carvedilol inhibits lipid peroxidation in

glaucoma. a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Purity: 99.96% Purity: 99.85% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Carvedilol phosphate hemihydrate Celiprolol hydrochloride (BM 14190 phosphate hemihydrate) Cat. No.: HY-B0006A Cat. No.: HY-B1264

Carvedilol phosphate hemihydrate (BM 14190 Celiprolol hydrochloride is a potent, selective phosphate hemihydrate) is a non-selective β/α-1 and orally active antagonist of β1-andrenoceptor blocker. Carvedilol phosphate hemihydrate inhibits with partial β2 agonist activity, therefore it is

lipid peroxidation with an IC50 of 5 μM. a selective adrenoreceptor modulator (SAM). Celiprolol hydrochloride demonstrates antihypertensive and antianginal activity. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Centanafadine Centanafadine hydrochloride (EB-1020) Cat. No.: HY-16736 (EB-1020 hydrochloride) Cat. No.: HY-16736A

Centanafadine is dual norepinephrine (NE)/dopamine Centanafadine (hydrochloride) is dual (DA) transporter inhibitor, also inhibits norepinephrine (NE)/dopamine (DA) transporter

serotonin transporter, with IC50s of 6 nM, 38 nM inhibitor, also inhibits serotonin transporter,

and 83 nM for human NE, DA and serotonin with IC50s of 6 nM, 38 nM and 83 nM for human NE, transporter , respectively. DA and serotonin transporter , respectively.

Purity: >98% Purity: 99.93% Clinical Data: Phase 3 Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

CGP 20712 A Cicloprolol hydrochloride (CGP 20712 mesylate) Cat. No.: HY-101355B Cat. No.: HY-U00066

CGP 20712 A (CGP 20712 mesylate) is a highly Cicloprolol is a partial β 1-adrenoceptor selective β1-adrenoceptor agonist .

antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.

Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 5 mg, 10 mg Size: 1 mg, 5 mg

Cimaterol-D7 Cimbuterol-D9 Cat. No.: HY-100935S Cat. No.: HY-131105S

Cimaterol-D7 is the deuterium labeled Cimaterol. Cimbuterol-D9 is the deuterium labeled Cimbuterol. Cimaterol is a potent agonist of β-adrenergic Cimbuterol is aβ-adrenergic agonist.

receptors (pEC50s=8.13, 8.78, and 6.62 for human β1, β2, and β3, respectively). Cimaterol has been used in farmed animals to increase carcass mass and to alter muscle and fat deposition. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

8 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

CL 316243 Clenproperol Cat. No.: HY-116771A Cat. No.: HY-100699

CL316243 is a highly potent selective Clenproperol is a β2-adrenergic agonist.

β3-adrenoceptor agonist with a EC50 of 3 nM, but is an extremely poor to β1/2- receptors.

Purity: 96.13% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 1 mg, 5 mg

Clenproperol-D7 Clonidine Cat. No.: HY-100699S Cat. No.: HY-12721

Clenproperol-D7 is the deuterium labeled Clonidine is an alpha 2-adrenergic agonist which is Clenproperol. Clenproperol is a β2-adrenergic used extensively in anesthesia research. agonist.

Purity: >98% Purity: 98.79% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Clonidine hydrochloride Clorprenaline D7 Cat. No.: HY-B0409A Cat. No.: HY-131106S

Clonidine hydrochloride is an agonist of Clorprenaline D7 is a deuterium labeled α2-adrenoceptor and potent antihypertensive Clorprenaline. Clorprenaline is a β2-adrenergic agent. receptor agonist that is implicated in bronchial expansion. Clorprenaline has the potential for asthma research.

Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Clorprenaline hydrochloride D2343 Cat. No.: HY-B1347 Cat. No.: HY-U00206

Clorprenaline hydrochloride is a β2-adrenergic D2343 is a β2-adrenoceptor agonist and also is an receptor agonist that is implicated in bronchial α1- adrenoceptor inhibitor. expansion. Clorprenaline has the potential for asthma research.

Purity: 99.59% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg Size: 1 mg, 5 mg

Dabuzalgron Dapiprazole hydrochloride (Ro 115-1240) Cat. No.: HY-117071 Cat. No.: HY-A0142A

Dabuzalgron (Ro 115-1240) is an orally active and Dapiprazole hydrochloride is a potent α-adrenergic selective α-1A adrenergic receptor agonist for blocking drug, which is used to reverse mydriasis the treatment of urinary incontinence. Dabuzalgron after eye examination. protects against Doxorubicin-induced cardiotoxicity by preserving mitochondrial function. Purity: 98.72% Purity: 99.97% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

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Deriglidole Detomidine (SL 86-0715) Cat. No.: HY-101683 Cat. No.: HY-B0163

Deriglidole is a peripheral adrenoceptor Detomidine, an imidazole derivative, is a potent antagonist with a high affinity for α2-adrenergic agonist. Detomidine produces

α2-adrenoceptors. dose-dependent sedative and analgesic effects.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Detomidine carboxylic acid Detomidine hydrochloride Cat. No.: HY-135895 Cat. No.: HY-B0163A

Detomidine carboxylic acid is the major urinary Detomidine hydrochloride, an imidazole derivative, metabolite of Detomidine. Detomidine is a is a potent α2-adrenergic agonist. Detomidine synthetic α2-adrenergic agonist and an animal hydrochloride produces dose-dependent sedative and analgesic sedative. Detomidine also has cardiac analgesic effects. and respiratory effects and an antidiuretic action. Purity: >98% Purity: 99.82% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Dexmedetomidine hydrochloride ((+)-Medetomidine Diacetolol D7 hydrochloride; (S)-Medetomidine hydrochloride) Cat. No.: HY-17034A Cat. No.: HY-100635S

Dexmedetomidine hydrochloride ((+)-Medetomidine Diacetolol D7 is a deuterium labeled Diacetolol. hydrochloride) is a potent, selective and orally Diacetolol is the major metabolite of Acebutolol.

active agonist of α2-adrenoceptor, with a Ki of Diacetolol is a β-adrenoceptor blocking and 1.08 nM. Dexmedetomidine hydrochloride shows anti-arrhythmic agent. 1620-fold selectivity against α1-adrenoceptor.

Purity: 98.54% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 1 mg

Dibenamine hydrochloride Dicentrine (N-​(2-​Chloroethyl)​dibenzylamine hydrochloride) Cat. No.: HY-128380 Cat. No.: HY-N6969

Dibenamine hydrochloride is a competitive and Dicentrine is a natural product isolated from the irreversible adrenergic blocking agent plant Lindera megaphylla with antihypertensive

and is known to modify the pharmacological effect. Dicentrine is an α1-adrenoceptor effects of epinephrine. Dibenamine hydrochloride antagonist which has effective against human cause a significant increase in the rate of hyperplastic prostates. destruction of I-epinephrine in the mouse. Purity: ≥98.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 250 mg Size: 1 mg, 5 mg

DL-Norepinephrine hydrochloride Dobutamine hydrochloride Cat. No.: HY-N7142 Cat. No.: HY-15746

DL-Norepinephrine hydrochloride is a synthetic Dobutamine hydrochloride is a synthetic phenylethylamine that mimics the sympathomimetic catecholamine that acts on α1-AR, β1-AR, β2-AR actions of the endogenous (α-1, β-1 andβ-2 adrenoceptors). Dobutamine norepinephrineDL-Norepinephrine hydrochloride is hydrochloride is a selective β1-AR agonist, a neurotransmitter targets α1 and β1 relatively weak activity at α1-AR and β2-AR. adrenoceptors, has an increasing effect… Purity: 99.53% Purity: 98.86% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 100 mg

10 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Dopexamine hydrochloride Doxazosin (FPL60278AR) Cat. No.: HY-U00205 (UK 33274) Cat. No.: HY-B0098

Dopexamine hydrochloride is a β2 adrenergic Doxazosin (UK 33274) is a quinazoline-derivative receptor agonist. that selectively antagonizes postsynaptic α1-adrenergic receptors.

Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Doxazosin D8 Doxazosin mesylate (UK 33274 D8) Cat. No.: HY-B0098S (UK 33274 mesylate) Cat. No.: HY-B0098A

Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin mesylate (UK 33274) is a Doxazosin (UK 33274). Doxazosin is a quinazoline-derivative that selectively quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. antagonizes postsynaptic α1 adrenergic receptors.

Purity: >98% Purity: 99.72% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g

Dronedarone Ecastolol (SR 33589) Cat. No.: HY-A0016 Cat. No.: HY-101691

Dronedarone (SR 33589), a derivative of amiodarone Ecastolol is a beta adrenergic receptor (HY-14187), is a class III antiarrhythmic antagonist, with antianginal activities. agent for the study of atrial fibrillation (AF) and atrial flutter.

Purity: 99.81% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 1 mg, 5 mg

Efaroxan hydrochloride Epanolol Cat. No.: HY-B1416A (Visacor; ICI141292) Cat. No.: HY-U00183

Efaroxan hydrochloride is a potent, selective and Epanolol (Visacor; ICI141292) is a potent orally active α2-adrenoceptor antagonist, with β-adrenoceptor partial agonist with a greater antidiabetic activity. Efaroxan hydrochloride is a affinity for β1- than β2-adrenoceptors. selective I1-Imidazoline receptor antagonist. Efaroxan hydrochloride can be used for the research of cardiovascular disease. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Esmolol hydrochloride Falintolol, (Z)- Cat. No.: HY-B1392 Cat. No.: HY-U00283

Esmolol hydrochloride is a beta adrenergic Falintolol, (Z)-, a new β-adrenergic antagonist, is receptor blocker. characterized by the presence of an oxime function.

Purity: 99.34% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 11

Fenmetozole Tosylate Fenoterol Cat. No.: HY-U00402 (Th-1165; Phenoterol) Cat. No.: HY-B0976

Fenmetozole Tosylate is an antagonist of the Fenoterol (Th-1165), a sympathomimetic agent, is a actions of ethanol, also antagonizes α2-adrenergic selective and orally active β2-adrenoceptor receptor, and acts as an antidepressant drug. agonist. Fenoterol is an effective bronchodilator and can be used for bronchospasm associated with asthma, bronchitis and other obstructive airway diseases research. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Fenoterol hydrobromide Fenspiride Hydrochloride (Th-1165a; Phenoterol hydrobromide) Cat. No.: HY-B0976A Cat. No.: HY-A0027

Fenoterol hydrobromide (Th-1165a), a Fenspiride Hcl is an α adrenergic and H1 histamine sympathomimetic agent, is a selective and orally receptor antagonist. IC50 value: Target: active β2-adrenoceptor agonist. Adrenergic receptor; H1 receptor Fenspiride hydrochloride is a bronchodilator with anti-inflammatory properties.

Purity: 99.71% Purity: 99.11% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 100 mg

FFN270 hydrochloride Fiduxosin Cat. No.: HY-131007 Cat. No.: HY-U00399

FFN270 hydrochloride, a fluorescent tracer of Fiduxosin is a potent α1-adrenoceptor antagonist,

norepinephrine, is a fluorescent substrate of the with Ki of 0.160 nM, 24.9 nM, and 0.920 nM for norepinephrine and vesicular monoamine α1a-, α1b-, and α1d-adrenoceptors, respectively. transporters.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg

G-Protein antagonist peptide G-Protein antagonist peptide TFA Cat. No.: HY-P1376 Cat. No.: HY-P1376A

G-Protein antagonist peptide is the substance G-Protein antagonist peptide TFA is the substance P-related peptide that inhibits binding of G P-related peptide that inhibits binding of G proteins to their receptors. G-Protein antagonist proteins to their receptors. G-Protein antagonist peptide competitively and reversibly inhibits peptide TFA competitively and reversibly inhibits M2 muscarinic receptor activation of Gi or Go M2 muscarinic receptor activation of Gi or Go and inhibits Gs activation by β-adrenoceptors. and inhibits Gs activation by β-adrenoceptors. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Glaucine Gramine (O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396) Cat. No.: HY-N3945 (Donaxine) Cat. No.: HY-N0166

Glaucine (O,O-Dimethylisoboldine) is an alkaloid Gramine (Donaxine) is a natural alkaloid isolated isolated from Glaucium flavum Crantz with from giant reed, acts as an active adiponectin

antitussive, bronchodilation and anti-inflammatory receptor (AdipoR) agonist, with IC50s of 3.2 and properties. 4.2 µM for AdipoR2 and AdipoR1, respectively. Gramine is also a human and mouse β2-Adrenergic receptor (β2-AR) agonist. Purity: >98% Purity: 99.45% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 50 mg

12 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Guanabenz Acetate Guanfacine (BR-750; Wy8678 acetate) Cat. No.: HY-B0566 Cat. No.: HY-17416A

Guanabenz (Acetate) (BR-750) is an alpha-2 Guanfacine is a selective α2A receptor agonist. selective adrenergic agonist used as an Target: α2A Receptor Guanfacine is a antihypertensive agent. sympatholytic. It is a selective α2A receptor agonist.

Purity: 98.39% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg, 500 mg Size: 1 mg, 5 mg

Guanfacine hydrochloride Guanoxabenz Cat. No.: HY-17416 (Hydroxyguanabenz) Cat. No.: HY-U00123

Guanfacine hydrochloride, an anti-hypertensive Guanoxabenz is an α2 adrenergic receptor agent, is a selective α2A-adrenoceptor agonist agonist, with a Ki of 4000 nM and the fully with Kd of 31 nM and displays 60-fold selectivity activated form 40 nM for an α2A adrenoceptor. over α2B-adrenoceptors. IC50 Value: 31 nM(Kd) Target: Adrenergic Receptor Guanfacine is a sympatholytic. Purity: 99.96% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Guanoxabenz hydrochloride Harmane (Hydroxyguanabenz hydrochloride) Cat. No.: HY-U00123A Cat. No.: HY-101392

Guanoxabenz (Hydroxyguanabenz) hydrochloride is an Harmane, a β-Carboline alkaloid (BCA), is a potent

α2 adrenergic receptor agonist, with a Ki of neurotoxin that causes severe action tremors and 4000 nM and the fully activated form 40 nM for an psychiatric manifestations. Harmane shows α2A adrenoceptor. 1000-fold selectivity for I1-Imidazoline

receptor (IC50=30 nM) over α2-adrenoceptor

(IC50=18 μM). Purity: 99.72% Purity: 99.73% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 100 mg

Higenamine Higenamine hydrochloride (Norcoclaurine) Cat. No.: HY-N2037 (Norcoclaurine hydrochloride) Cat. No.: HY-N2037A

Higenamine (Norcoclaurine), a β2-AR agonist, is a Higenamine hydrochloride (Norcoclaurine key component of the Chinese herb aconite root hydrochloride), a β2-AR agonist, is a key that prescribes for treating symptoms of heart component of the Chinese herb aconite root that failure in the oriental Asian countries. prescribes for treating symptoms of heart failure Higenamine (Norcoclaurine) has anti-apoptotic in the oriental Asian countries. effects. Purity: >98% Purity: 99.04% Clinical Data: Phase 1 Clinical Data: No Development Reported Size: 5 mg, 10 mg, 20 mg Size: 10 mM × 1 mL, 100 mg

HOKU-81 Hydrocortisone 17-butyrate (4-Hydroxytulobuterol) Cat. No.: HY-50291 (Cortisol 17-butyrate; Hydrocortisone butyrate) Cat. No.: HY-B0983

HOKU-81 (4-Hydroxytulobuterol) is one of the Hydrocortisone 17-butyrate is an adrenocortico metabolites of Tulobuterol (HY-B1810). HOKU-81 is hormone. a potent and selective β2-adrenoceptor stimulant. HOKU-81 has bronchodilating effect.

Purity: ≥95.0% Purity: 99.93% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 25 mg Size: 100 mg

www.MedChemExpress.com 13

Hydroxybupropion ICI 118,551 hydrochloride Cat. No.: HY-100637 (ICI 118551 hydrochloride) Cat. No.: HY-13951

Hydroxybupropion is the major active metabolite of ICI 118,551 (hydrochloride) is a highly selective

Bupropion. Hydroxybupropion is metabolized by β2 adrenergic receptor antagonist, with Kis of CYP2B6. Bupropion is an atypical antidepressant 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, and smoking-cessation agent. Hydroxybupropion respectively.

inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Purity: 99.91% Purity: 99.64% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

ICI 89406 Idazoxan hydrochloride Cat. No.: HY-15726 (RX 781094 hydrochloride) Cat. No.: HY-14561A

ICI 89406 is a selective β1 adrenergic receptor Idazoxan hydrochloride (RX 781094 hydrochloride)

antagonist amenable to labelling with positron is an α2-adrenoceptor antagonist and is also a emitters, for PET. imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like drugs (IMs). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Imoxiterol Indacaterol (RP 58802B) Cat. No.: HY-101585 Cat. No.: HY-14299

Imoxiterol (RP 58802B) is a β-adrenergic agonist. Indacaterol(Onbrez; Arcapta) is an ultra-long-acting β-adrenoceptor agonist. IC50 value: Target: β-adrenoceptor Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Purity: 93.86% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Indacaterol maleate Indanidine (QAB149) Cat. No.: HY-14299A Cat. No.: HY-101717

Indacaterol (QAB149) maleate is an Indanidine is an alpha-adrenergic agonist. ultra-long-acting β-adrenoceptor agonist.

Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Indoramin D5 Isamoltane hemifumarate (Indoramine D5; Wy-21901 D5) Cat. No.: HY-12760S Cat. No.: HY-19578B

Indoramin D5 is deuterium labeled Indoramin, which Isamoltane hemifumarate is a selective antagonist

is a piperidine antiadrenergic agent. of 5-HT1B receptor, with an IC50 of 39 nM for 125 inhibits the binding of [ I]ICYP to 5-HT1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor

ligand, with an IC50 of 8.4 nM. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

14 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Isoferulic acid Isoprenaline hydrochloride (3-Hydroxy-4-methoxycinnamic acid) Cat. No.: HY-N0761 (Isoproterenol hydrochloride) Cat. No.: HY-B0468

Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) Isoprenaline hydrochloride is a non-selective is a cinnamic acid derivative that has β-adrenergic receptor agonist with potent antidiabetic activity. Isoferulic acid binds to peripheral vasodilator, bronchodilator, and and activates α1-adrenergic receptors (IC50=1.4 µM) cardiac stimulating activities. to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Purity: 99.92% Purity: 98.61% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 200 mg, 1 g

Isoxsuprine hydrochloride Ivabradine D3 Hydrochloride Cat. No.: HY-B1270 Cat. No.: HY-B0162AS1

Isoxsuprine hydrochloride is a beta-adrenergic Ivabradine D3 Hydrochloride is the deuterium receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ labeled Ivabradine hydrochloride. Ivabradine for myometrial and placcntal beta-adrenergic hydrochloride is a new If inhibitor with IC50 of 2.9 receptor, respectively. Isoxsuprine hydrochloride μM, and used as a pure heart rate lowering agent. is also a NMDA receptor antagonist.

Purity: 99.87% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 200 mg Size: 1 mg, 5 mg

Ivabradine D6 hydrochloride Ivabradine hydrochloride Cat. No.: HY-B0162AS Cat. No.: HY-B0162A

Ivabradine D6 hydrochloride is the deuterium Ivabradine hydrochloride is an orally labeled Ivabradine hydrochloride. Ivabradine bioavailable, hyperpolarization-activated, cyclic hydrochloride is a new If inhibitor with IC50 of 2.9 nucleotide-gated (HCN) channel blocker. μM, and used as a pure heart rate lowering agent.

Purity: >98% Purity: 99.87% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg

JP1302 dihydrochloride Ko-3290 Cat. No.: HY-103213 Cat. No.: HY-101721

JP1302 dihydrochloride is a selective, high Ko-3290 is an antagonist of β-adrenoceptor, with affinity antagonist of the alpha2C-adrenoceptor cardioselectivity and antilipolytic effects in

(α2C-adrenoceptor), with a Kb value animals.

(antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM.

Purity: 99.83% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

KUL-7211 racemate L-765314 Cat. No.: HY-19673A Cat. No.: HY-101385

KUL-7211 racemate is the racemate of KUL-7211. L-765314 is a potent and selective α1b adrenergic

KUL-7211 is a selective β-adrenoceptor agonist. receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.

Purity: >98% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 15

L-771688 L755507 Cat. No.: HY-U00237 Cat. No.: HY-19334

L-771688 is a highly selective α1A-Adrenoceptor L755507 is a potent, selective agonist of β3-AR

antagonist with a Ki of 0.43±0.02 nM. with an IC50 of 35 nM.

Purity: >98% Purity: 98.33% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg

Labetalol hydrochloride Landiolol hydrochloride (AH-5158 hydrochloride; Sch-15719W) Cat. No.: HY-B1108 (ONO1101 hydrochloride) Cat. No.: HY-100607A

Labetalol hydrochloride is a mixed alpha/beta Landiolol hydrochloride (ONO1101 hydrochloride) is adrenergic antagonist that is used to treat high a highly beta1 selective ultra-short acting blood pressure. beta-blocker (β1/β2 selectivity=255:1, a half-life of 4min) acts as an adrenoceptor antagonist.

Purity: ≥98.0% Purity: 99.96% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg

Latrepirdine dihydrochloride Levalbuterol (Dimebolin dihydrochloride) Cat. No.: HY-14537 ((R)-Albuterol; (R)-Salbutamol; Levosalbutamol) Cat. No.: HY-B1675

Latrepirdine dihydrochloride is a neuroactive Levalbuterol ((R)-Albuterol; (R)-Salbutamol) is a compound with antagonist activity at short-acting β2-adrenergic receptor agonist histaminergic, α-adrenergic, and serotonergic and the active (R)-enantiomer of Salbutamol. receptors. Latrepirdine stimulates amyloid Levalbuterol is a more potent bronchodilator than precursor protein (APP) catabolism and Salbutamol and has the potential for the treatment amyloid-β (Aβ) secretion. of COPD.
. Purity: 99.75% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg Size: 1 mg, 5 mg

Levalbuterol tartrate Levobetaxolol hydrochloride (Levosalbutamol tartrate) Cat. No.: HY-17457 ((S)-Betaxolol hydrochloride; AL-1577A) Cat. No.: HY-B0381B

Levosalbutamol tartrate(levalbuterol) is the Levobetaxolol hydrochloride is a beta-adrenergic R-enantiomer of the short-acting β2-adrenergic receptor inhibitor (beta blocker) that can lower receptor agonist salbutamol. IC50 Value: Target: the pressure in the eye. Levobetaxolol β2-adrenergic receptor Levosalbutamol and hydrochloride can be used for the research of salbutamol produced significantly better glaucoma. bronchodilator responses than placebo. Purity: >98% Purity: 98.53% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Lidanserin Lofexidine (ZK-33839) Cat. No.: HY-101815 Cat. No.: HY-B1052A

Lidanserin (ZK-33839) acts as a 5-HT2A and Lofexidine is a selective α2-receptor agonist,

α1-adrenergic receptor antagonist. commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.

Purity: ≥98.0% Purity: 99.08% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg Size: 10 mM × 1 mL, 50 mg

16 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Lofexidine hydrochloride Lusaperidone (Baq-168; MDL-14042) Cat. No.: HY-B1052 (R107474) Cat. No.: HY-U00117

Lofexidine (hydrochloride) is a selective Lusaperidone (R107474) is an α2 adrenergic

α2-receptor agonist, commonly used to alleviate receptor antagonist with Kis of 0.13 and 0.15 nM the physical symptoms of heroin and other types of for α2A and α2C, respectively. opioid withdrawal.

Purity: 99.94% Purity: 97.74% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg Size: 5 mg, 10 mg, 20 mg

LY377604 Mabuterol-D9 Cat. No.: HY-13713 Cat. No.: HY-13338S

LY377604 is a human β3-adrenergic receptor Mabuterol-D9 is a deuterium labeled Mabuterol. agonist with an EC50 of 2.4 nM and also a β1- Mabuterol is an agonist of the β2-adrenergic and β2-adrenergic receptor antagonist. receptor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Mapenterol hydrochloride Mebeverine D6 Hydrochloride Cat. No.: HY-136435 Cat. No.: HY-A0078S

Mapenterol hydrochloride is a type of Mebeverine D6 Hydrochloride is the deuterium β2-adrenoceptor agonist. labeled Mebeverine, which is an antimuscarinic.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Medetomidine Medetomidine hydrochloride Cat. No.: HY-17034 (MPV785) Cat. No.: HY-17034B

Medetomidine(Domtor) is a potent, highly selective Medetomidine hydrochloride is an agonist of α2-adrenoceptor agonist (Ki values are 1.08 and adrenergic alpha-2 receptor, which is used in 1750 nM for α2- and α1-adrenoceptors veterinary medicine for its analgesic and sedative respectively). properties.

Purity: 99.97% Purity: 99.88% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Meranzin Metaproterenol Cat. No.: HY-N3298 (Orciprenaline) Cat. No.: HY-B1276A

Meranzin is an absorbed bioactive compound from Metaproterenol (Orciprenaline) is a direct-acting the Traditional Chinese Medicine (TCM) sympathomimetic and a β2-adrenergic receptor (β2AR)

Chaihu-Shugan-San (CSS). Meranzin, isolated from agonist with an IC50 of 68 nM. Metaproterenol leaves of Murraya exotica L., regulates the also has anti-inflammatory activity. shared alpha 2-adrenoceptor and involves the AMPA-ERK1/2–BDNF signaling pathway. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 17

Metaproterenol hemisulfate Methyldopa (Orciprenaline hemisulfate) Cat. No.: HY-B1276 (L-(-)-α-Methyldopa; MK-351) Cat. No.: HY-B0225

Metaproterenol hemisulfate (Orciprenaline Methyldopa (L-(-)-α-Methyldopa), a potent hemisulfate) is a direct-acting sympathomimetic antihyoertensive agent, is an alpha-adrenergic and a β2-adrenergic receptor (β2AR) agonist with agonist (selective for α2-adrenergic receptors).

an IC50 of 68 nM. Metaproterenol hemisulfate also Methyldopa is a prodrug and is metabolized has anti-inflammatory activity. (α-Methylepinephrine) in the central nervous system. Purity: 99.86% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 500 mg

Methyldopa hydrate Methyldopa hydrochloride (L-(-)-α-Methyldopa hydrate; MK-351 hydrate) Cat. No.: HY-B0225B (L-(-)-α-Methyldopa hydrochloride; MK-351 hydrochloride) Cat. No.: HY-B0225A

Methyldopa hydrate (L-(-)-α-Methyldopa hydrate), a Methyldopa hydrochloride (L-(-)-α-Methyldopa potent antihyoertensive agent, is an hydrochloride) hydrochloride, a potent alpha-adrenergic agonist (selective for antihyoertensive agent, is an alpha-adrenergic α2-adrenergic receptors). Methyldopa hydrate is a agonist (selective for α2-adrenergic receptors). prodrug and is metabolized (α-Methylepinephrine) in the central nervous system. Purity: ≥98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g Size: 500 mg

Methyldopate hydrochloride Metipranolol Cat. No.: HY-B1696A Cat. No.: HY-121567

Methyldopate hydrochloride is an ethyl ester Metipranolol is a nonselective and orally active hydrochloride prodrug of α-Methyldopa (α-MD; β-adrenergic receptor antagonist. Metipranolol can HY-B0225). Methyldopa (L-(-)-α-Methyldopa) is an be used for hypertension and glaucoma research. α-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopate hydrochloride has the potential for severe hypertension research. Purity: >98% Purity: 98.36% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg

Metipranolol hydrochloride Metoprolol Cat. No.: HY-16316 Cat. No.: HY-17503

Metipranolol hydrochloride is a non-selective β Metoprolol (Toprol) is a selective β1 receptor adrenergic receptor blocking agent. blocker used in treatment of several diseases of the cardiovascular system, especially hypertension. IC50 value: Target: β1 receptor.

Purity: 99.92% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Metoprolol Succinate Metoprolol Tartrate Cat. No.: HY-17503A Cat. No.: HY-17503B

Metoprolol Succinate (Toprol XL) is a selective β1 Metoprolol is a cardioselective β1-adrenergic receptor blocker used in treatment of several blocking agent. Target: β1- adrenergic Receptor diseases of the cardiovascular system, especially Patients took 50 mg metoprolol twice daily with hypertension. IC50 value: Target: β1 receptor. weekly titration to response or 200 mg twice daily.

Purity: 99.54% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg Size: 1 mg, 5 mg

18 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

MG 1 Midaglizole hydrochloride Cat. No.: HY-U00110 ((±)-DG5128; DG5128) Cat. No.: HY-U00165

MG 1 is an α1 adrenergic receptor antagonist. Midaglizole hydrochloride (DG5128) is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4

times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Mirabegron Mirtazapine (YM178) Cat. No.: HY-14773 (Org3770; 6-Azamianserin) Cat. No.: HY-B0352

Mirabegron is a selective β3-adrenoceptor Mirtazapine (Org3770) is a potent and orally agonist with EC50 of 22.4 nM. active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also

a 5-HT2, 5-HT3, histamine H1 receptor and

α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively. Purity: 99.79% Purity: 99.97% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg

Moxisylyte hydrochloride Nadolol (Thymoxamine hydrochloride) Cat. No.: HY-B1435 (SQ-11725) Cat. No.: HY-B0804

Moxisylyte (hydrochloride) is (alpha 1-blocker) Nadolol (SQ-11725) is a non-selective and orally antagonist, it can vasodilates cerebral vessels active β-adrenergic receptors blocker and is a without reducing blood pressure. It is also used substrate of organic anion transporting locally in the eye to reverse the mydriasis caused polypeptide 1A2 (OATP1A2). Nadolol has the the by phenylephrine and other sympathomimetic agents. potential for high blood pressure, angina pectoris and vascular headaches research. Purity: 99.96% Purity: 98.58% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 1 g Size: 100 mg, 250 mg, 500 mg

Nadolol D9 Naftopidil (SQ-11725 D9) Cat. No.: HY-B0804S (KT-611; BM-15275) Cat. No.: HY-B0391

Nadolol D9 (SQ-11725 D9) is the deuterium labeled Naftopidil (KT-611) is is a selective

Nadolol. Nadolol is a non-selective and orally alpha1-adrenoceptor antagonist, with Kis of 3.7 nM, active β-adrenergic receptors blocker. 20 nM and 1.2 nM for the cloned human α1a-, α1b-

and α1d-adrenoceptor subtypes, respectively. Naftopidil has antiproliferative effects.

Purity: >98% Purity: 98.97% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g, 10 g

Naftopidil dihydrochloride Naftopidil hydrochloride (KT-611 dihydrochloride; BM-15275 dihydrochloride) Cat. No.: HY-B0391A (KT-611 hydrochloride; BM-15275 hydrochloride) Cat. No.: HY-B0391B

Naftopidil dihydrochloride (KT-611 Naftopidil hydrochloride (KT-611 hydrochloride) is dihydrochloride) is a selective alpha1-adrenoceptor a selective alpha1-adrenoceptor antagonist, with antagonist, with Kis of 3.7 nM, 20 nM and 1.2 nM Kis of 3.7 nM, 20 nM and 1.2 nM for the cloned for the cloned human α1a-, α1b- and human α1a-, α1b- and α1d-adrenoceptor subtypes,

α1d-adrenoceptor subtypes, respectively. respectively. Naftopidil hydrochloride has antiproliferative effects. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: Phase 4 Size: 1 mg, 5 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 19

Naminterol Naphazoline hydrochloride Cat. No.: HY-101822 Cat. No.: HY-B0446

Naminterol is a phenethanolamine derivative, is a Naphazoline hydrochloride is an ocular

β2 adrenoceptor agonist with bronchodilatory vasoconstrictor and imidazoline derivative properties. Naminterol is used for treatment of sympathomimetic amine. Target: Adrenergic Receptor asthma. Naphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride.

Purity: >98% Purity: 98.56% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g, 10 g

Nebivolol Nebivolol hydrochloride (R 065824) Cat. No.: HY-B0203 (R 065824 hydrochloride) Cat. No.: HY-B0203A

Nebivolol selectively inhibits β1- adrenergic Nebivolol hydrochloride selectively inhibits β1- receptor with IC50 of 0.8 nM. Target: β1- adrenergic receptor with IC50 of 0.8 nM. Target: adrenergic receptor Nebivolol reduces cell β1- adrenergic receptor Nebivolol reduces cell proliferation of human coronary smooth muscle proliferation of human coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent maner. concentration- and time-dependent maner. Purity: >98% Purity: 99.76% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 500 mg

Nefazodone hydrochloride Nicergoline (BMY-13754; MJ-13754-1) Cat. No.: HY-B1396 Cat. No.: HY-B0702

Nefazodone hydrochloride (BMY-13754) is a potent Nicergoline, an ergoline derivative ester of

and selective 5HT2A (Ki=5.8 nM) antagonist with bromonicotinic acid, is a potent, selective and

moderate inhibition of 5-HT and noradrenaline orally active antagonist of α1A-adrenoceptor.

uptake (IC50 of 290 and 300 nM, respectively). Nicergoline has vasodilator effects. Nicergoline also has ameliorative effects on cognitive function in mouse models of Alzheimer's disease. Purity: 99.02% Purity: 99.62% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Noradrenaline tartrate Norepinephrine (Levarterenol tartrate; L-Noradrenaline tartrate) Cat. No.: HY-13715C (Levarterenol; L-Noradrenaline) Cat. No.: HY-13715

Norepinephrine tartrate (Levarterenol tartrate), a Norepinephrine (Levarterenol; L-Noradrenaline) is

naturally occurring chemical in the body that acts a β1-selective adrenergic receptor agonist with

as both a stress hormone and neurotransmitter, is EC50 of 5.37 μM.

a β1-selective adrenergic receptor agonist with

EC50 of 5.37 μM.

Purity: >98% Purity: 98.08% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 500 mg

Norepinephrine bitartrate monohydrate (Levarterenol Norepinephrine hydrochloride (Levarterenol hydrochloride; bitartrate monohydrate; …) Cat. No.: HY-13715B L-Noradrenaline hydrochloride) Cat. No.: HY-13715A

Norepinephrine bitartrate monohydrate Norepinephrine hydrochloride (Levarterenol

(Levarterenol bitartrate monohydrate; hydrochloride) is a β1-selective adrenergic

L-Noradrenaline bitartrate monohydrate) is a receptor agonist with EC50 of 5.37 μM.

β1-selective adrenergic receptor agonist with

EC50 of 5.37 μM.

Purity: 99.75% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 500 mg, 1 g, 5 g Size: 500 mg

20 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

NRA-0160 O-Desmethyl Mebeverine alcohol Cat. No.: HY-101641 (Mebeverine metabolite O-desmethyl Mebeverine alcohol) Cat. No.: HY-G0008

NRA-0160 is a selective dopamine D4 receptor O-Desmethyl Mebeverine alcohol is a metabolite of antagonist, with a Ki value of 0.48 nM and with Mebeverine, which is a potent α1 repector negligible affinity for dopamine D2 receptor inhibitor, causing relaxation of the

(Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat gastrointestinal tract.

5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

O-Desmethyl Mebeverine alcohol hydrochloride (Mebeverine Octopamine hydrochloride metabolite O-desmethyl Mebeverine alcohol hydrochloride) Cat. No.: HY-G0008A ((±)-p-Octopamine hydrochlorid) Cat. No.: HY-B0528A

O-Desmethyl Mebeverine alcohol hydrochloride is a Octopamine ((±)-p-Octopamine) hydrochloride, a metabolite of Mebeverine, which is a potent α1 biogenic monoamine structurally related to repector inhibitor, causing relaxation of the noradrenaline, acts as a neurohormone, a gastrointestinal tract. neuromodulator and a neurotransmitter in invertebrates.

Purity: 98.00% Purity: 99.28% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 2 mg, 5 mg, 10 mg, 50 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Olanzapine Olanzapine D3 (LY170053) Cat. No.: HY-14541 (LY170053 D3) Cat. No.: HY-14541S

Olanzapine (LY170053) is a selective monoaminergic Olanzapine D3 (LY170053 D3) is the deuterium antagonist with high affinity binding to serotonin labeled Olanzapine.

H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Purity: 99.89% Purity: 99.09% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg, 500 mg Size: 5 mg

OPC-28326 Oxprenolol hydrochloride Cat. No.: HY-101610 (Ba 39089) Cat. No.: HY-B1486

OPC-28326 is a selective peripheral vasodilator Oxprenolol hydrochloride (Ba 39089) is an orally and an angatonist of α2-adrenergic receptor, with bioavailable β-adrenergic receptor (β-AR)

Ki of 2040, 285, and 55nM for α2A-, α2B- and antagonist with a Ki of 7.10 nM in a radioligand α2C-adrenoceptors, respectively. binding assay using rat heart muscle.

Purity: >98% Purity: 99.86% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Paliperidone Pamatolol (9-Hydroxyrisperidone) Cat. No.: HY-A0019 Cat. No.: HY-U00019

Paliperidone (9-Hydroxyrisperidone), the major Pamatolol is a cardioselective beta-adrenoceptor active metabolite of Risperidone, is a dopamine antagonist without sympathomimetic activity. D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Purity: 99.87% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 21

Pardoprunox Pardoprunox hydrochloride (SLV-308; DU-126891) Cat. No.: HY-14958 (SLV-308 hydrochloride; DU-126891 hydrochloride) Cat. No.: HY-14958A

Pardoprunox (SLV-308) is a partial dopamine D2 Pardoprunox (SLV-308) hydrochloride is a partial and D3 receptor partial agonist and a serotonin dopamine D2 and D3 receptor partial agonist

5-HT1A receptor agonist, with pEC50s of 8, 9.2, and a serotonin 5-HT1A receptor agonist, with

and 6.3, respectively. pEC50s of 8, 9.2, and 6.3, respectively.

Purity: >98% Purity: 98.24% Clinical Data: Phase 3 Clinical Data: Phase 3 Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Pargolol hydrochloride Penbutolol sulfate (Ko 1400 hydrochloride) Cat. No.: HY-101658 ((-)-Terbuclomine) Cat. No.: HY-B1154

Pargolol hydrochloride is a β adrenergic Penbutolol sulfate is able to bind to both beta-1 receptor antagonist. adrenergic receptors and beta-2 adrenergic receptors (the two subtypes), thus making it a non-selective β blocker. Penbutolol is a sympathomimetic drugused in the treatment of high blood pressure. Purity: >98% Purity: 99.62% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Perphenazine Perphenazine D8 Dihydrochloride Cat. No.: HY-A0077 Cat. No.: HY-A0077AS

Perphenazine is a typical antipsychotic drug, Perphenazine D8 Dihydrochloride is the deuterium

inhibits 5-HT2Areceptor, Alpha-1A adrenergic labeled Perphenazine, which is a typical receptor, Dopamine receptor D2/D3, D2L receptor, antipsychotic drug(5-HT, Dopamine receptor

and Histamine H1 receptor, with Ki values of ligand). 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.

Purity: 99.72% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 1 mg, 5 mg

PF-610355 Phenoxybenzamine hydrochloride Cat. No.: HY-14296 Cat. No.: HY-B0431A

PF-610355 is a long-acting inhaled Phenoxybenzamine hydrochloride is a selective

β2-adrenoreceptor agonist, with an EC50 of antagonist of both α-adrenoceptor and 0.26 nM. PF-610355 has the potential for the study calmodulin that is commonly used for the of asthma and COPD. treatment of hypertension, specifically caused by pheochromocytoma.

Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 200 mg, 500 mg, 1 g

Phentolamine mesylate Phenylephrine (Phentolamine methanesulfonate) Cat. No.: HY-B0362A ((R)-(-)-Phenylephrine; L-Phenylephrine) Cat. No.: HY-B0769

Phentolamine mesylate (Phentolamine (R)-(-)-Phenylephrine is a selective

methanesulfonate) is a reversible, non-selective, α1-adrenoceptor agonist primarily used as a and orally active blocker of α1 and α2 decongestant. adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance.

Purity: 99.90% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 10 mM × 1 mL, 500 mg

22 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Phenylephrine hydrochloride ((R)-(-)-Phenylephrine Phenylethanolamine A hydrochloride; L-Phenylephrine hydrochloride) Cat. No.: HY-B0471 Cat. No.: HY-131103

(R)-(-)-Phenylephrine hydrochloride is a selective Phenylethanolamine A acts as a β-adrenergic

α1-adrenoceptor agonist with pKis of 5.86, 4.87 agonist. Phenylethanolamine A is a byproduct and 4.70 for α1D, α1B and α1A receptors during the Ractopamine synthesis process. respectively.

Purity: 99.95% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Phenylethanolamine A-D3 Pimozide Cat. No.: HY-131103S (R6238) Cat. No.: HY-12987

Phenylethanolamine A-D3 is a deuterium labeled Pimozide is a dopamine receptor antagonist,

Phenylethanolamine A. Phenylethanolamine A acts as with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine a β-adrenergic agonist. Phenylethanolamine A is a D2, D3 and D1 receptors, respectively, and also byproduct during the Ractopamine synthesis has affinity at α1-adrenoceptor, with a Ki of 39 process. nM; Pimozide also inhibits STAT3 and STAT5.

Purity: >98% Purity: 99.88% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 50 mg

Pimozide D4 Pindolol (R6238 D4) Cat. No.: HY-12987S (LB-46) Cat. No.: HY-B0982

Pimozide D4 (R6238 D4) is a deuterium labeled Pindolol (LB-46) is a nonselective β-blocker with Pimozide. partial beta-adrenergic receptor agonist activity, also functions as a 5-HT1A receptor weak partial antagonist (Ki=33nM).

Purity: >98% Purity: 99.91% Clinical Data: Phase 4 Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

Piperoxan hydrochloride Piribedil (Benodaine hydrochloride) Cat. No.: HY-100850 Cat. No.: HY-12707

Piperoxan (Benodaine) hydrochloride is an α2 Piribedil is a dopamine D2 receptor (D2R) adrenoceptor antagonist. Piperoxan hydrochloride agonist which also displays antagonist property at is the first-generation antihistamine. hα1A-adrenoceptor (hα1A-AR).

Purity: 99.39% Purity: 99.77% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg, 200 mg, 500 mg

Piribedil D8 Practolol (ET-495 D8) Cat. No.: HY-12707S Cat. No.: HY-119802

Piribedil D8 (ET-495 D8) is the deuterium labeled Practolol is a potent and selective β1-adrenergic Piribedil, which is an antiparkinsonian agent. receptor antagonist. Practolol can be used for the research of cardiac arrhythmias.

Purity: >98% Purity: 99.86% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mg, 25 mg, 50 mg, 100 mg

www.MedChemExpress.com 23

Prazosin Prazosin hydrochloride Cat. No.: HY-B0193 Cat. No.: HY-B0193A

Prazosin is an alpha-adrenergic blocker and is a Prazosin hydrochloride is an alpha-adrenergic sympatholytic drug used to treat high blood blocker and is a sympatholytic drug used to treat pressure and anxiety, PTSD, and panic disorder. high blood pressure and anxiety, PTSD, and panic Target: Adrenergic Receptor Prazosin, is a disorder. sympatholytic drug used to treat high blood pressure and anxiety, PTSD, andpanic disorder. Purity: >98% Purity: 99.93% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 200 mg, 500 mg

Pronethalol Pronethalol hydrochloride ((±)-Pronethalo) Cat. No.: HY-B1238 ((±)-Pronethalo hydrochloride) Cat. No.: HY-B1238A

Pronethalol ((±)-Pronethalo) is a non-selective Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs). arteriovenous malformation (AVMs). Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 100 mg, 250 mg, 500 mg

Propranolol Propranolol D7 hydrochloride Cat. No.: HY-B0573B Cat. No.: HY-B0573S

Propranolol is a nonselective β-adrenergic receptor Propranolol D7 hydrochloride is a deuterium (βAR) antagonist, has high affinity for the β1AR labeled Propranolol hydrochloride. Propranolol

and β2AR with Ki values of 1.8 nM and 0.8 nM, hydrochloride is a nonselective β-adrenergic respectively. Propranolol inhibits [3H]-DHA receptor (βAR) antagonist, has high affinity for

binding to rat brain membrane preparation with an the β1AR and β2AR with Ki values of 1.8 nM and 0.8

IC50 of 12 nM. nM, respectively. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Propranolol hydrochloride QF0301B Cat. No.: HY-B0573 Cat. No.: HY-101690

Propranolol hydrochloride is a nonselective QF0301B is an α1 adrenergic receptor antagonist β-adrenergic receptor (βAR) antagonist, has high and a low α2 adrenoceptor, 5-HT2A, and histamine

affinity for the β1AR and β2AR with Ki values of H1 receptor blocker. 1.8 nM and 0.8 nM, respectively.

Purity: 99.79% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg, 1 g Size: 1 mg, 5 mg

Rauwolscine hydrochloride (α-Yohimbine hydrochloride; Reboxetine mesylate Corynanthidine hydrochloride; Isoyohimbine hydrochloride) Cat. No.: HY-12710A (FCE20124 mesylate; PNU155950E mesylate) Cat. No.: HY-14560C

Rauwolscine hydrochloride is a potent and specific Reboxetine mesylate (FCE20124 mesylate) is a

α2 adrenergic receptor antagonist with a Ki of 12 potent, selective, and specific noradrenaline nM. reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the

uptake of norepinephrine, with a Ki of 8 nM.

Purity: 99.95% Purity: 99.87% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 50 mg, 100 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg

24 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Rilmenidine Rilmenidine hemifumarate Cat. No.: HY-100490 Cat. No.: HY-100490A

Rilmenidine, an innovative antihypertensive agent, Rilmenidine hemifumarate, an innovative is an orally active, selective I1 imidazoline antihypertensive agent, is an orally active, receptor agonist. Rilmenidine is an alpha selective I1 imidazoline receptor agonist. 2-adrenoceptor agonist. Rilmenidine induces Rilmenidine hemifumarate is an alpha autophagy. 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Purity: >98% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 5 mg, 10 mg

Rilmenidine phosphate Ritanserin Cat. No.: HY-100490B (R 55667) Cat. No.: HY-10791

Rilmenidine phosphate, an innovative Ritanserin (R 55667) is a highly potent, antihypertensive agent, is an orally active, relatively selective, orally active, long acting selective I1 imidazoline receptor agonist. antagonist of 5-HT2 receptor, with an IC50 of

Rilmenidine phosphate is an alpha 2-adrenoceptor 0.9 nM, less active on Histamine H1, Dopamine agonist. Rilmenidine phosphate induces autophagy. D2, Adrenergic α1, Adrenergic α2 receptors.

Purity: ≥98.0% Purity: 99.78% Clinical Data: Launched Clinical Data: Phase 2 Size: 50 mg, 100 mg, 250 mg Size: 10 mM × 1 mL, 5 mg

Ritodrine hydrochloride Ro 363 (DU21220 hydrochloride) Cat. No.: HY-B0452 Cat. No.: HY-123268

Ritodrine hydrochloride (DU21220 hydrochloride) is Ro 363, an effective inotropic stimulant, is a a β-2 adrenergic receptor agonist. Target: β-2 potent and highly selective β1-adrenoceptor Adrenergic Receptor Ritodrine is a tocolytic drug, agonist. RO 363 is a cardiovascular modulator that used to stop premature labor. reduces diastolic blood pressure and pronounces increases in myocardial contractility.

Purity: 99.90% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

Ro 363 hydrochloride Rotigotine Cat. No.: HY-123268A (N-0437; N-0923) Cat. No.: HY-75502

Ro 363 hydrochloride, an effective inotropic Rotigotine (N-0437; N-0923) is a full agonist of stimulant, is a potent and highly selective dopamine receptor, a partial agonist of the β1-adrenoceptor agonist. Ro 363 hydrochloride is 5-HT1A receptor, and an antagonist of the a cardiovascular modulator that reduces diastolic α2B-adrenergic receptor, with Kis of 0.71nM, blood pressure and pronounces increases in 4-15nM, and 83nM for the dopamine D3 receptor myocardial contractility. and D2, D5, D4 receptors, and dopamine… Purity: 95.88% Purity: 99.98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Rotigotine Hydrochloride RS 17053 hydrochloride (N-0923 Hydrochloride) Cat. No.: HY-A0007 (RS-17053) Cat. No.: HY-101336

Rotigotine Hydrochloride (N-0923 Hydrochloride) is RS 17053 hydrochloride is a potent and selective a full agonist of dopamine receptor, a partial α1A adrenoceptor antagonist, with a pKi value agonist of the 5-HT1A receptor, and an of 9.1 in native cell membrane and a pA2 value antagonist of the α2B-adrenergic receptor, with Ki of 9.8 in functional assays. of 0.71nM, 4-15nM, and 83nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine… Purity: 99.47% Purity: 99.25% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 25

Salbutamol Salbutamol hemisulfate (Albuterol; AH-3365) Cat. No.: HY-B1037 (Albuterol hemisulfate; AH-3365 hemisulfate) Cat. No.: HY-B0436

Salbutamol is a short-acting β2-adrenergic Salbutamol Hemisulfate (Albuterol hemisulfate) is receptor agonist used for the relief of a short-acting β2 adrenergic receptor agonist bronchospasm in conditions such as asthma and Target: β2 Adrenergic Receptor Salbutamol chronic obstructive pulmonary disease (COPD). Hemisulfate (Albuterol hemisulfate) is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and… Purity: >98% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg, 500 mg

Salmeterol Salmeterol xinafoate (GR33343X) Cat. No.: HY-14302 (GR 33343X xinafoate) Cat. No.: HY-17453

Salmeterol (GR33343X) is a potent and selective Salmeterol (GR 33343X) xinafoate is a potent and human β2 adrenoceptor agonist. Salmeterol shows selective human β2 adrenoceptor agonist. potent stimulation of cAMP accumulation in CHO Salmeterol shows potent stimulation of cAMP cells expressing human β2, β1 and β3 accumulation in CHO cells expressing human β2, β1

adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, and β3 adrenoceptors with pEC50s of 9.6, 6.1, respectively. and 5.9, respectively. Purity: 99.88% Purity: 99.88% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Salmeterol-D3 Scopine Cat. No.: HY-135119 (6,7-Epoxytropine) Cat. No.: HY-B0459

Salmeterol-D3 is a deuterium labeled Salmeterol. Scopine is the metabolite of anisodine, which is a Salmeterol is a potent and selective human β2 α1-adrenergic receptor agonist and used in the adrenoceptor agonist. Salmeterol shows potent treatment of acute circulatory shock. stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors

with pEC50s of 9.6, 6.1, and 5.9, respectively. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Scopine hydrochloride Sertindole (6,7-Epoxytropine hydrochloride) Cat. No.: HY-B0459A (Lu 23-174) Cat. No.: HY-14543

Scopine hydrochloride (6,7-Epoxytropine Sertindole, a neuroleptic, is one of the newer hydrochloride) is the metabolite of anisodine, antipsychotic medications available. Target: which is a α1-adrenergic receptor agonist and used Multi-target In vitro studies showed that in the treatment of acute circulatory shock. sertindole exerts a potent antagonism at serotonin 5-HT2A, 5-HT2C, dopamine D2, and αl adrenergic receptors. Purity: ≥98.0% Purity: 99.76% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Setiptiline Silodosin (Org-8282) Cat. No.: HY-32329 (KAD 3213; KMD 3213) Cat. No.: HY-10122

Setiptiline (Org-8282) is a serotonin receptor Silodosin (KAD 3213; KMD 3213) is a potent, antagonist. Setiptiline is a tetracyclic selective and orally active α1A-adrenergic receptor antidepressant (TeCA) which acts as a (α1A-AR) blocker. noradrenergic and specific serotonergic antidepressant (NaSSA).

Purity: 96.54% Purity: 99.96% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

26 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Solabegron Sotalol D6 hydrochloride (GW 427353) Cat. No.: HY-19436 Cat. No.: HY-B0437AS

Solabegron (GW 427353) is a selective Sotalol D6 hydrochloride is a deuterium labeled

β3-adrenergic receptor agonist, stimulating cAMP Sotalol hydrochloride. Sotalol hydrochloride is a accumulation in Chinese hamster ovary cells non-selective competitive β-adrenergic receptor expressing the human β3-AR, with an EC50 value antagonist that also exhibits Class III of 22 nM. antiarrhythmic properties by its inhibition of potassium channels. Purity: 99.91% Purity: >98% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg Size: 5 mg, 10 mg

Sotalol hydrochloride Spiperone hydrochloride (MJ 1999) Cat. No.: HY-B0437 (Spiroperidol hydrochloride) Cat. No.: HY-B1371A

Sotalol hydrochloride (MJ 1999) is a non-selective Spiperone hydrochloride (Spiroperidol competitive β-adrenergic receptor antagonist that hydrochloride) is a selective dopamine D2 also exhibits Class III antiarrhythmic properties receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, by its inhibition of potassium channels. ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5

receptors, respectively) and 5-HT2A/5-HT1A

receptor (Kis of 1 nM/49 nM)… Purity: 99.04% Purity: ≥99.0% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg, 100 mg, 200 mg, 500 mg, 1 g Size: 10 mg

Spirendolol SR59230A (Li 32-468; S 32-468; Substance 32468) Cat. No.: HY-101817 Cat. No.: HY-100672

Spirendolol is a β adrenergic receptor SR59230A is a potent, selective, and blood-brain antagonist. barrier penetrating β3-adrenergic receptor

antagonist with IC50s of 40, 408, and 648 nM for β3, β1, and β2 receptors, respectively.

Purity: >98% Purity: ≥98.0% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg

SR59230A hydrochloride Synephrine Cat. No.: HY-103200 (Oxedrine) Cat. No.: HY-N0132

SR59230A hydrochloride is a potent, selective, and Synephrine (Oxedrine) is an α-adrenergic and blood-brain barrier penetrating β3-adrenergic β-adrenergic agonist derived from the Citrus receptor antagonist with IC50s of 40, 408, and aurantium, it has sympathomimetic and 648 nM for β3, β1, and β2 receptors, respectively. structural similarities to ephedra and ephedrine alkaloids.

Purity: 99.88% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 5 mg

Synephrine hydrochloride Talibegron hydrochloride (Oxedrine hydrochloride) Cat. No.: HY-N0132A (ZD2079 hydrochloride) Cat. No.: HY-15378

Synephrine hydrochloride (Oxedrine hydrochloride) Talibegron hydrochloride (ZD2079 hydrochloride) is is an α-adrenergic and β-adrenergic agonist derived a potent β3-adrenoceptor agonist with a pD2 of from the Citrus aurantium, it has 3.72 on phenylephrine-preconstricted rat sympathomimetic and structural similarities to mesenteric artery. Talibegron hydrochloride has ephedra and ephedrine alkaloids. potent vasorelaxant effect.

Purity: 99.57% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 100 mg, 500 mg Size: 1 mg, 5 mg

www.MedChemExpress.com 27

Talipexole dihydrochloride Tamsulosin (B-HT 920 dihydrochloride) Cat. No.: HY-A0008 ((R)-(-)-YM12617 free base; LY253351 free base) Cat. No.: HY-B0661

Talipexole dihydrochloride (B-HT 920 Tamsulosin ((R)-(-)-YM12617 free base) is an

dihydrochloride) is a dopamine D2 receptor inhibitor of α1-adrenergic receptor. Tamsulosin agonist, α2-adrenoceptor agonist and 5-HT3 is used for the research of prostatic hyperplasia. receptor antagonist, which displays Tamsulosin attenuates abdominal aortic aneurysm antiParkinsonian activity. growth in animal models.

Purity: 99.88% Purity: 99.62% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Tamsulosin hydrochloride TD-5471 hydrochloride ((R)-(-)-YM12617; LY253351) Cat. No.: HY-B0661A Cat. No.: HY-19942A

Tamsulosin hydrochloride ((R)-(-)-YM12617) is an TD-5471 hydrochloride is a potent and selective

inhibitor of α1-adrenergic receptor. Tamsulosin full agonist of the human β2-adrenoceptor. hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth in animal models. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Tedatioxetine hydrobromide Teoprolol (Lu AA24530 hydrobromide) Cat. No.: HY-101755 Cat. No.: HY-U00016

Tedatioxetine (Lu AA24530) hydrobromide acts as a Teoprolol is a β-adrenergic receptor blocker. serotonin and norepinephrine (NE)-preferring

triple reuptake inhibitor (TRI) and 5-HT2A,

5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist
. ,.

Purity: 99.98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg Size: 1 mg, 5 mg

Terazosin Terazosin dimer impurity dihydrochloride Cat. No.: HY-B0371 Cat. No.: HY-131449

Terazosin is a quinazoline derivative and a Terazosin dimer impurity dihydrochloride, a dimer competitive and orally active α1-adrenoceptor of Terazosin, is an impurity of Terazosin. antagonist. Terazosin works by relaxing blood Terazosin is a quinazoline derivative and a vessels and the opening of the bladder. Terazosin competitive and orally active α1-adrenoceptor has the potential for benign prostatic hyperplasia antagonist. (BPH) and high blood pressure treatment. Purity: >98% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 5 mg, 10 mg

Terazosin hydrochloride Terazosin hydrochloride dihydrate Cat. No.: HY-B0371F Cat. No.: HY-B0371A

Terazosin hydrochloride is a quinazoline Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and hydrochloride dihydrate works by relaxing blood the opening of the bladder. vessels and the opening of the bladder.

Purity: >98% Purity: 99.80% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 100 mg

28 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Terbutaline sulfate Tertatolol (Terbutaline hemisulfate) Cat. No.: HY-B0802 ((±)​-​Tertatolol; Racemic Tertatolol; dl-​Tertatolol) Cat. No.: HY-U00356

Terbutaline sulfate is a β2-adrenergic receptor Tertatolol is a potent antagonist of agonist; a fast-acting bronchodilator and a beta-adrenoceptor and 5-HT receptor, with tocolytic to delay premature labor. unique renal vasodilatatory effects.

Purity: ≥98.0% Purity: >98% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g Size: 1 mg, 5 mg

Tetrahydroalstonine Tetrahydrozoline Cat. No.: HY-N1163 (Tetryzoline) Cat. No.: HY-B0556

Tetrahydroalstonine, a indole alkaloid isolated Tetrahydrozoline (Tetryzoline), a derivative of from the fruits of Rhazya stricta, is a selective imidazoline, is an α-adrenergic agonist that causes alpha 2-adrenoceptor antagonist. vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion.

Purity: 99.95% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 10 mM × 1 mL, 1 mg, 5 mg Size: 1 mg, 5 mg

Tetrahydrozoline hydrochloride Tiodazosin (Tetryzoline hydrochloride) Cat. No.: HY-B0556A (BL-5111) Cat. No.: HY-100255

Tetrahydrozoline hydrochloride (Tetryzoline Tiodazosin is a potent competitive postsynaptic hydrochloride), a derivative of imidazoline, is an alpha adrenergic receptor antagonist. α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion. Purity: 99.90% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 500 mg Size: 1 mg, 5 mg

Tizanidine Tizanidine hydrochloride Cat. No.: HY-B0194 Cat. No.: HY-B0194A

Tizanidine is an α2-adrenergic receptor agonist Tizanidine hydrochloride is an α2-adrenergic and inhibits neurotransmitter release from CNS receptor agonist and inhibits neurotransmitter noradrenergic neurons. Target: α2-adrenergic release from CNS noradrenergic neurons. Target: receptor Tizanidine is a drug that is used as a α2-adrenergic receptor Tizanidine is a drug that muscle relaxant. It is a centrally acting α2 is used as a muscle relaxant. It is a centrally adrenergic agonist. acting α2 adrenergic agonist. Purity: >98% Purity: 99.67% Clinical Data: Launched Clinical Data: Launched Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

Todralazine Todralazine hydrochloride (Ecarazine) Cat. No.: HY-B1001 (Ecarazine hydrochloride) Cat. No.: HY-B1001A

Todralazine (Ecarazine) is an anti-hypertensive Todralazine hydrochloride (Ecarazine agent, acts as a β2AR blocker, with antioxidant hydrochloride) is an anti-hypertensive agent, acts and free radical scavenging activity. as a β2AR blocker, with antioxidant and free radical scavenging activity.

Purity: >98% Purity: 98.17% Clinical Data: Launched Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 10 mg, 50 mg, 100 mg

www.MedChemExpress.com 29

Tolazoline Tolazoline hydrochloride (Imidaline; NSC35110) Cat. No.: HY-A0066 (Imidaline hydrochloride; NSC35110 hydrochloride) Cat. No.: HY-A0066A

Tolazoline(Imidaline) is a non-selective Tolazoline (hydrochloride)(Imidaline competitive α-adrenergic receptor antagonist. (hydrochloride)) Hcl is a non-selective competitive α-adrenergic receptor antagonist.

Purity: >98% Purity: ≥98.0% Clinical Data: Launched Clinical Data: Launched Size: 500 mg Size: 10 mM × 1 mL, 500 mg, 1 g, 5 g

Tropodifene Tulobuterol (Tropaphen) Cat. No.: HY-U00313 (C-78 free base) Cat. No.: HY-B1810

Tropodifene (Tropaphen) is an α-Adrenergic receptor Tulobuterol (C-78 free base) is a long-acting

inhibitor. β2-adrenoceptor agonist, which reduces the frequency of exacerbations of chronic obstructive pulmonary disease and bronchial asthma.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: Launched Size: 1 mg, 5 mg Size: 1 mg, 5 mg

Tulobuterol hydrochloride Ulimorelin (C-78) Cat. No.: HY-W011733 (TZP-101) Cat. No.: HY-14903

Tulobuterol hydrochloride (C-78) is a long-acting Ulimorelin (TZP-101) is a ghrelin receptor (GRLN)

β2-adrenoceptor agonist, which reduces the agonist with an EC50 of 29 nM and a Ki of 16 nM. frequency of exacerbations of chronic obstructive Ulimorelin is a prokinetic agent and causes pulmonary disease and bronchial asthma.. vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition. Purity: 99.82% Purity: >98% Clinical Data: Launched Clinical Data: Phase 3 Size: 10 mM × 1 mL, 50 mg, 100 mg, 500 mg Size: 1 mg, 5 mg

Urapidil Urapidil D6 Cat. No.: HY-B0716 Cat. No.: HY-B0716S

Urapidil is an α1 adrenoreceptor antagonist and Urapidil D6 is a deuterium labeled Urapidil.

a 5-HT1A receptor agonist. Urapidil is an α1-adrenoreceptor antagonist and a

5-HT1A receptor agonist.

Purity: 99.94% Purity: >98% Clinical Data: Launched Clinical Data: No Development Reported Size: 10 mM × 1 mL, 50 mg Size: 1 mg, 5 mg

Urapidil hydrochloride Vanilpyruvic acid Cat. No.: HY-B0354A (Vanylpyruvic acid) Cat. No.: HY-101416

Urapidil HCl is an α1-adrenoceptor antagonist and Vanilpyruvic acid is a catecholamine metabolite 5-HT1A receptor agonist. and precursor to vanillactic acid.

Purity: ≥99.0% Purity: 98.28% Clinical Data: Launched Clinical Data: No Development Reported Size: 5 mg, 10 mg, 25 mg Size: 10 mM × 1 mL, 10 mg

30 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]

Vatinoxan hydrochloride Vilanterol (MK-467 hydrochloride; L-659066 hydrochloride) Cat. No.: HY-19057A (GW642444) Cat. No.: HY-14300

Vatinoxan hydrochloride (MK-467 Vilanterol (GW642444) is a long-acting hydrochloride;L-659066 hydrochloride) is a β2-adrenoceptor (β2-AR) agonist with 24 h peripheral α2 adrenergic receptor antagonist. activity. The pEC50s for β2-AR,β1-AR and

β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.

Purity: 99.86% Purity: 96.66% Clinical Data: No Development Reported Clinical Data: Launched Size: 5 mg, 10 mg, 25 mg Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg

Vilanterol trifenatate Xylometazoline hydrochloride (GW642444 trifenatate) Cat. No.: HY-14300A Cat. No.: HY-B0475

Vilanterol trifenatate (GW642444 trifenatate) is a Xylometazoline hydrochloride is an α-adrenoceptor long-acting β2-adrenoceptor (β2-AR) agonist agonist commonly used as nasal decongestant. with inherent 24-hour activity. The pEC50s for

β2-AR, β1-AR and β3-AR are 10.37, 6.98 and 7.36, respectively.

Purity: 99.20% Purity: 99.88% Clinical Data: Launched Clinical Data: Launched Size: 10 mM × 1 mL, 5 mg, 10 mg, 50 mg, 100 mg Size: 10 mM × 1 mL, 500 mg, 1 g

Yohimbine Yohimbine Hydrochloride Cat. No.: HY-12715 Cat. No.: HY-N0127

Yohimbine is a potent and relatively nonselective Yohimbine Hydrochloride is an alpha alpha 2-adrenergic receptor (AR) antagonist, with 2-adrenoreceptor antagonist, blocking the pre- and IC50 of 0.6 μM. postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.

Purity: 98.10% Purity: 99.69% Clinical Data: Launched Clinical Data: Launched Size: 500 mg Size: 10 mM × 1 mL, 500 mg, 1 g

YS-49 YS-49 monohydrate Cat. No.: HY-15477 Cat. No.: HY-15477A

YS-49 is a PI3K/Akt (a downstream target of RhoA) YS-49 (monohydrate) is a PI3K/Akt (a downstream activator, to reduce RhoA/PTEN activation in the target of RhoA) activator, to reduce RhoA/PTEN 3-methylcholanthrene-treated cells. YS-49 inhibits activation in the 3-methylcholanthrene-treated angiotensin II (Ang II)-stimulated proliferation cells. YS-49 inhibits angiotensin II (Ang of VSMCs via induction of heme oxygenase (HO)-1. II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. Purity: 95.38% Purity: 99.56% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 10 mg, 50 mg Size: 10 mM × 1 mL, 10 mg, 50 mg

Zilpaterol-d7 Zinterol Cat. No.: HY-A0072S (MJ 9184) Cat. No.: HY-14304

Zilpaterol-d7 is a deuterium labeled Zilpaterol. Zinterol (MJ 9184) is a potent and selective

β2-adrenoceptor agonist. Zinterol increases ICa in

a concentration-dependent manner with an EC50 of 2.2 nM.

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg

www.MedChemExpress.com 31

Zinterol hydrochloride ZK-90055 hydrochloride (MJ 9184 hydrochloride) Cat. No.: HY-14304A Cat. No.: HY-U00293

Zinterol hydrochloride (MJ 9184 hydrochloride) is ZK-90055 hydrochloride is a β2 adrenergic a potent and selective β2-adrenoceptor agonist. receptor agonist.

Zinterol hydrochloride increases ICa in a

concentration-dependent manner with an EC50 of 2.2 nM. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits. Purity: ≥99.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10 mM × 1 mL, 1 mg, 5 mg, 10 mg Size: 1 mg, 5 mg

α1 adrenoceptor-MO-1 β3-AR agonist 1 Cat. No.: HY-U00333 Cat. No.: HY-101514

α1 adrenoceptor-MO-1, an S enantiomer, has β3-AR agonist 1 (compound 15) is a highly potent, affinity at alpha 1 adrenergic receptor, shows selective, and orally available β3-adrenergic

alphalytic activity, and possesses analgesic receptor (β3-AR) agonist (EC50=18 nM), being action; more active than R enantiomer. inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold).

Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg

β3-AR agonist 2 Cat. No.: HY-U00391

β3-AR agonist 2 is a potent and selective

β3-adrenergic receptor (β3-AR) agonist with an

EC50 of 8 nM.

Purity: >98% Clinical Data: No Development Reported Size: 1 mg, 5 mg

32 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected]