Søgeprotokol for Nationale Kliniske Retningslinjer

Projekttitel/aspekt NKR Demens - Medicin - Primærlitteratur (RCT) Fagkonsulent Anne Mette Skov Sørensen / Elisabeth Bandak Projektleder Casper Larsen Søgespecialist Kirsten Birkefoss Senest opdateret 18.04.2018

Fokuserede spørgsmål PICO 1: Bør behandling med demenslægemidler seponeres hos personer med meget svær demens?

PICO 2: Bør personer med demens i langvarig behandling med antipsykotisk medicin revurderes med henblik på om behandlingen skal fortsætte eller seponeres?

PICO 3: Bør personer med demens og søvnbesvær og/eller døgnrytmeforstyrrelse behandles med melatonin?

PICO 4: Bør personer med demens og søvnbesvær og/eller døgnrytmeforstyrrelse behandles med mirtazapin eller mianserin?

PICO 5: Bør personer med demens i behandling med antidepressiva (> 6 måneder) revurderes med henblik på om behandlingen skal fortsætte eller seponeres?

PICO 6: Bør behandling med urologiske spasmolytika med antikolinerg virkning undlades hos personer med demens?

PICO 7: Bør man forsøge seponering af paracetamol ved usikker indikation hos personer med demens?

PICO 8: Bør man forsøge seponering af opioider ved usikker indikation hos personer med demens?

PICO 9: Bør behandlingsmålet for blodtryk være højere hos personer med moderat til svær demens > 80år? Søgetermer Se søgestrategierne under de enkelte PICOs/PIROs

Inklusions- og Sprog: Engelsk, tysk, dansk, norsk og svensk eksklusionskriterier År: Se de enkelte PICOs Population: Voksne fra og med 18 år Publikationstyper: RCT

Informationskilder

DATABASE INTERFACE DATO FOR SØGNING Medline OVID 26.01.2018 - 18.04.2018 EMBASE OVID 26.01.2018 - 18.04.2018 PsycINFO OVID 26.01.2018 - 09.03.2018 CINAHL EBSCO 26.01.2018 - 14.03.2018

Note

• Søgetermer og inklusions- og eksklusionskriterier er tilpasset de enkelte databaser. • Dubletter er så vidt muligt frasorteret ved hjælp af RefWorks. De fundne referencer overføres til Covidence (referenceværktøj) • Fuldtekster præsenteres i Covidence i pdf-format • Søgestrategi for hver enkelt database præsenteres – hvis muligt vises det eksplicit hvor mange referencer den enkelte søgestreng genererer

SØGESTRATEGI

Søgning efter primærlitteratur (RCT)

PICO 1: Bør behandling med demenslægemidler seponeres hos personer med meget svær demens?

Søgt 05.03.2018

Medline

21 exp Withholding treatment/ 14037 22 Substance Withdrawal Syndrome/ 20348 23 Deprescriptions/ 126 24 (discontinu* or deprescrib* or deprescrip* or withdraw* or with-draw* or taper* or 293448 cessat*).ti,ab,kw,kf. 25 ((withhold* or with-hold* or withheld* or with-held* or stop* or pause* or end*3) adj4 65369 (treat* or therap* or prescrib* or prescription* or drug* or medication* or medicine)).ti,ab,kw,kf. 26 or/21-25 366052 27 11 and 20 and 26 544 28 limit 27 to (randomized controlled trial or controlled clinical trial) 125 29 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 586309 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 30 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 252245 31 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155727 32 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 125306 33 or/29-32 714010 34 27 and 33 224 35 28 or 34 238 36 limit 35 to (danish or english or german or norwegian or swedish) 231 37 limit 36 to (systematic reviews or meta analysis) 53 38 36 not 37 177

Embase

Database(s): Embase 1974 to 2018 March 02 Search Strategy: # Searches Results 1 Dementia/ 102210 2 exp Alzheimer Disease/ 167894 3 exp primary progressive aphasia/ 2968 4 exp Primary Progressive Nonfluent Aphasia/ 660 5 exp frontotemporal dementia/ 14224 6 exp Multiinfarct Dementia/ 10848 7 exp Frontotemporal Lobar Degeneration/ 14224 8 exp pick presenile dementia/ 1264 9 exp diffuse lewy body disease/ 6930 10 mental deterioration/ 5124 11 exp presenile dementia/ 656 12 exp senile dementia/ 3459

13 exp "mixed depression and dementia"/ 120 14 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 265089 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw. 15 14 and (2016* or 2017* or 2018*).em. 59828 16 or/1-13,15 275853 17 exp cholinesterase inhibitor/ 82646 18 (Acetylcholinesterase* or Acetylcholine Hydrolase or Acetylthiocholinesterase* or AChEI or 39563 cholinesterase block* or choline esterase inhibitor* or ((acetylcholinesteras* or cholinesteras*) adj2 inhibit*) or (anti adj cholinesteras*) or anticholinesteras* or CHEI).ti,ab,kw. 19 (NMDA adj2 antagonist*).ti,ab,kw. 14183 20 (Donepezil* or Memantin* or Rivastigmin* or Galantamin*).ti,ab,kw. 10775 21 or/17-20 117769 22 exp withdrawal syndrome/ or exp treatment withdrawal/ or drug withdrawal/ 32455 23 exp Deprescription/ 128 24 (discontinu* or deprescrib* or deprescrip* or withdraw* or with-draw* or taper* or 410919 cessat*).ti,ab,kw. 25 ((withhold* or with-hold* or withheld or with-held* or stop* or pause* or end*3) adj4 103269 (treat* or therap* or prescrib* or prescription* or drug* or medication* or medicine)).ti,ab,kw. 26 or/22-25 513283 27 16 and 21 and 26 1095 28 limit 27 to (randomized controlled trial or controlled clinical trial) 212 29 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 803980 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 30 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 348569 31 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 211217 32 ((patient* or person* or participant* or population) adj3 (random* or blind* or 184992 mask*)).ti,ab. 33 or/29-32 983501 34 27 and 33 403 35 28 or 34 445 36 limit 35 to (danish or english or german or norwegian or swedish) 434 37 limit 36 to ("systematic review" or meta analysis or letter or note) 61 38 36 not 37 373

PsycINFO

Database(s): PsycINFO 1806 to February Week 4 2018 Search Strategy: # Searches Results 1 exp Dementia/ 68719 2 exp Neurodegenerative Diseases/ 69745 3 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 118181 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id. 4 or/1-3 139923 5 exp Cholinesterase Inhibitors/ 2389 6 (AChEI or cholinesterase block* or choline esterase inhibitor* or acetylcholinesterase 3129 inhibit* or cholinesterase inhibit* or anti cholinesterase* or anticholinesteras* or CHEI).ti,ab,id. 7 (NMDA adj2 antagonist*).ti,ab,id. 3913 8 (Donepezil* or Memantin* or Rivastigmin* or Galantamin*).ti,ab,id. 3199 9 or/5-8 9183 10 (discontinu* or deprescrib* or deprescrip* or withdraw* or with-draw* or taper* or 72555 cessat*).ti,ab,id. 11 ((withhold* or with-hold* or withheld* or with-held* or stop* or pause* or end*3) adj4 10197 (treat* or therap* or prescrib* or prescription* or drug* or medication* or medicine)).ti,ab,id. 12 or/10-11 81396 13 4 and 9 and 12 342 14 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 90603 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,id. 15 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) 45200 adj2 (blind* or mask*))).ti,ab,id. 16 ((patient* or person* or participant* or population) adj3 (random* or blind* or 19985 mask*)).ti,ab. 17 or/14-16 122066 18 13 and 17 122 19 limit 18 to (danish or english or german or norwegian or swedish) 121 20 limit 19 to ("0830 systematic review" or 1200 meta analysis) 14 21 19 not 20 107

PICO 2: Bør personer med demens i langvarig behandling med antipsykotisk medicin revurderes med henblik på om behandlingen skal fortsætte eller seponeres?

Søgt 12.02.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to February 07, 2018 Search Strategy: # Searches Results 1 Dementia/ 43949 2 exp Alzheimer Disease/ 81147 3 exp Aphasia, Primary Progressive/ 639 4 exp Primary Progressive Nonfluent Aphasia/ 94 5 exp Dementia, Vascular/ 6067 6 exp Dementia, Multi-Infarct/ 1082 7 exp Frontotemporal Lobar Degeneration/ 3318 8 exp Frontotemporal Dementia/ 2374 9 exp Lewy Body Disease/ 2684 10 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 186863 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/1-10 205369 12 exp Antipsychotic Agents/ 114444 13 (anti-psychotic* or antipsychotic* or anti psychotic* or ((major adj2 (tranquilizer* or 42477 tranquiliser*)) or Neuroleptics)).ti,ab,kw,kf. 14 ((Tranquiliz* or tranquilis* or Neuroleptic) adj2 (drug* or agent* or pill*1 or medication* or 8193 medicine)).ti,ab,kw,kf. 15 Risperidone/ 5759 16 Aripiprazole/ 1980 17 Quetiapine Fumarate/ 2483 18 Clozapine/ 7549 19 Sulpiride/ 3856 20 Haloperidol/ 15309 21 (Risperidon* or Aripiprazol* or Olanzapin* or Quetiapin* or Clozapin* or Amisulprid* or 70973 Sulpirid* or halperidol* or haloperidol* or Chlorpromazin* or levomepromazin* or promazin* or acepromazin* or triflupromazin* or cyamemazin* or chlorproethazin* or dixyrazin* or fluphenazin* or perphenazin* or prochlorperazin* or thiopropazat* or trifluoperazin* or acetophenazin* or thioproperazin* or butaperazin* or perazin* or periciazin* or thioridazin* or mesoridazin* or pipotiazin* or trifluperidol* or melperon* or moperon* or pipamperon* or bromperidol* or benperidol* or droperidol* or fluanison* or

oxypertin* or molindon* or sertindol* or ziprasidon* or lurasidon* or flupentixol* or clopenthixol* or chlorprothixen* or tiotixen* or zuclopenthixol* or fluspirilen* or pimozid* or penfluridol* or loxapin* or asenapin* or clotiapin* or sultoprid* or tiaprid* or remoxiprid* or veraliprid* or levosulpirid* or prothipendyl* or mosapramin* or zotepin* or paliperidon* or iloperidon*).ti,ab,kw,kf. 22 or/12-21 146460 23 11 and 22 4223 24 limit 23 to randomized controlled trial 213 25 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 583412 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 26 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 251502 27 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155294 28 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 124707 29 or/25-28 710792 30 23 and 29 629 31 24 or 30 664 32 limit 31 to (yr="2012-2018" and (danish or english or german or norwegian or swedish)) 181 33 limit 32 to (systematic reviews or guideline or practice guideline) 52 34 32 not 33 129

Embase

Database(s): Embase 1974 to 2018 February 12 Search Strategy: # Searches Results 1 Dementia/ 101350 2 exp Alzheimer Disease/ 165232 3 exp primary progressive aphasia/ 2913 4 exp Primary Progressive Nonfluent Aphasia/ 646 5 exp frontotemporal dementia/ 14003 6 exp Dementia, Multi-Infarct/ 10771 7 exp Frontotemporal Lobar Degeneration/ 14003 8 exp pick presenile dementia/ 1258 9 exp diffuse lewy body disease/ 6801 10 mental deterioration/ 5082 11 exp presenile dementia/ 655 12 exp senile dementia/ 3455 13 exp "mixed depression and dementia"/ 120 14 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 260904 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw.

15 or/1-14 311723 16 exp Neuroleptic Agent/ 255094 17 (anti-psychotic* or antipsychotic* or anti psychotic* or ((major adj2 (tranquilizer* or 65473 tranquiliser*)) or Neuroleptics)).ti,ab,kw. 18 ((Tranquiliz* or tranquilis* or Neuroleptic) adj2 (drug* or agent* or pill*1 or medication* or 6585 medicine)).ti,ab,kw. 19 Risperidone/ 33296 20 Aripiprazole/ 12943 21 Olanzapine/ 30654 22 Quetiapine/ 20859 23 Clozapine/ 30211 24 Amisulpride/ 5105 25 Haloperidol/ 55633 26 (Risperidon* or Aripiprazol* or Olanzapin* or Quetiapin* or Clozapin* or Amisulprid* or 88071 Sulpirid* or halperidol* or haloperidol* or Chlorpromazin* or levomepromazin* or promazin* or acepromazin* or triflupromazin* or cyamemazin* or chlorproethazin* or dixyrazin* or fluphenazin* or perphenazin* or prochlorperazin* or thiopropazat* or trifluoperazin* or acetophenazin* or thioproperazin* or butaperazin* or perazin* or periciazin* or thioridazin* or mesoridazin* or pipotiazin* or trifluperidol* or melperon* or moperon* or pipamperon* or bromperidol* or benperidol* or droperidol* or fluanison* or oxypertin* or molindon* or sertindol* or ziprasidon* or lurasidon* or flupentixol* or clopenthixol* or chlorprothixen* or tiotixen* or zuclopenthixol* or fluspirilen* or pimozid* or penfluridol* or loxapin* or asenapin* or clotiapin* or sultoprid* or tiaprid* or remoxiprid* or veraliprid* or levosulpirid* or prothipendyl* or mosapramin* or zotepin* or paliperidon* or iloperidon*).ti,ab,kw. 27 or/16-26 270806 28 15 and 27 12346 29 limit 28 to randomized controlled trial 437 30 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 796737 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 31 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 345820 32 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 210199 33 ((patient* or person* or participant* or population) adj3 (random* or blind* or 183576 mask*)).ti,ab. 34 or/30-33 975338 35 28 and 34 1273 36 29 or 35 1393 37 limit 36 to (yr="2012-2018" and (danish or english or german or norwegian or swedish)) 420 38 limit 37 to ("systematic review" or letter or note) 66 39 37 not 38 354

PsycINFO

Database(s): PsycINFO 1806 to February Week 1 2018 Search Strategy: # Searches Results 1 exp Dementia/ 68508 2 exp Neurodegenerative Diseases/ 69506 3 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 91401 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id. 4 or/1-3 114481 5 exp Neuroleptic Drugs/ 29300 6 (anti-psychotic* or antipsychotic* or anti psychotic* or ((major adj2 (tranquilizer* or 31884 tranquiliser*)) or Neuroleptics)).ti,ab,id. 7 ((Tranquiliz* or tranquilis* or Neuroleptic) adj2 (drug* or agent* or pill*1 or medication* or 3664 medicine)).ti,ab,id. 8 (Risperidon* or Aripiprazol* or Olanzapin* or Quetiapin* or Clozapin* or Amisulprid* or 31216 Sulpirid* or halperidol* or haloperidol* or Chlorpromazin* or levomepromazin* or promazin* or acepromazin* or triflupromazin* or cyamemazin* or chlorproethazin* or dixyrazin* or fluphenazin* or perphenazin* or prochlorperazin* or thiopropazat* or trifluoperazin* or acetophenazin* or thioproperazin* or butaperazin* or perazin* or periciazin* or thioridazin* or mesoridazin* or pipotiazin* or trifluperidol* or melperon* or moperon* or pipamperon* or bromperidol* or benperidol* or droperidol* or fluanison* or oxypertin* or molindon* or sertindol* or ziprasidon* or lurasidon* or flupentixol* or clopenthixol* or chlorprothixen* or tiotixen* or zuclopenthixol* or fluspirilen* or pimozid* or penfluridol* or loxapin* or asenapin* or clotiapin* or sultoprid* or tiaprid* or remoxiprid* or veraliprid* or levosulpirid* or prothipendyl* or mosapramin* or zotepin* or paliperidon* or iloperidon*).ti,ab,id. 9 or/5-8 52440 10 4 and 9 2783 11 (((random* or cluster-random* or crossover or cross-over or blind* or mask*) adj4 (trial*1 73717 or study or studies or analy*)) or rct).ti,ab,id. 12 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) 45042 adj (blind* or mask*))).ti,ab,id. 13 ((patient* or person* or participant* or population) adj3 (random* or blind* or 19901 mask*)).ti,ab. 14 or/11-13 108286 15 10 and 14 439 16 limit 15 to (yr="2012-2018" and (danish or english or german or norwegian or swedish)) 101

PICO 3: Bør personer med demens og søvnbesvær og/eller døgnrytmeforstyrrelse behandles med melatonin?

Søgt 12.03.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March 07 2018 Search Strategy:

# Searches Results 1 Dementia/ 44279 2 exp Alzheimer Disease/ 81748 3 exp Aphasia, Primary Progressive/ 649 4 exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ 6084 6 exp Dementia, Multi-Infarct/ 1083 7 exp Frontotemporal Lobar Degeneration/ 3379 8 exp Frontotemporal Dementia/ 2425 9 exp Lewy Body Disease/ 2712 10 exp Cognitive Dysfunction/ 7732 11 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 232434 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw,kf. 12 or/1-11 250677 13 Sleep/ 46147 14 exp Sleep deprivation/ 8652 15 exp Sleep Hygiene/ 66 16 exp Sleep Latency/ 10 17 exp Sleep Wake Disorders/ 77089 18 exp Sleep Apnea Syndromes/ 30477 19 Wakefulness/ 16294 20 (sleep* or Insomnia* or dyssomnia* or somnambul* or wakeful* or 167460 somnolence).ti,ab,kw,kf. 21 ((circadian or biological clock) adj6 (disturb* or deprivation or disorder* or difficult* or 5595 disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea)).ti,ab,kw,kf. 22 ((circadian or biological clock) adj6 (treatment* or therap* or intervention* or plan* or 11210

program* or structur* or strateg* or protocol* or hygiene or pattern* or regulation or cycle* or syndrome or quality)).ti,ab,kw,kf. 23 or/13-22 203443 24 "Sleep Initiation and Maintenance Disorders"/dt 3281 25 Sleep disorders/dt 2236 26 Sleep/dt, de 9076 27 ((sleep* or sedation or sedate) adj1 (medicine or medication* or drug* or agent* or 3232 pill*)).ti,ab,kw,kf. 28 Melatonin/ 17642 29 melatonin*.mp. 23287 30 or/24-29 38911 31 12 and 23 and 30 612 32 limit 31 to (randomized controlled trial or controlled clinical trial) 67 33 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or 586880 mask*) adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 34 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 252411 35 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155839 36 ((patient* or person* or participant* or population) adj3 (random* or blind* or 125429 mask*)).ti,ab. 37 or/33-36 714648 38 31 and 37 126 39 32 or 38 136 40 limit 39 to (yr="2016-2018" and (danish or english or german or norwegian or swedish)) 20 41 limit 40 to (systematic reviews or review) 10 42 40 not 41 10

Embase

Database(s): Embase 1974 to 2018 March 09 Search Strategy: # Searches Results 1 Dementia/ 102336 2 exp Alzheimer Disease/ 168144 3 exp primary progressive aphasia/ 2971 4 exp Primary Progressive Nonfluent Aphasia/ 661 5 exp frontotemporal dementia/ 14248 6 exp Multiinfarct dementia/ 10864 7 exp Frontotemporal Lobar Degeneration/ 14248 8 exp pick presenile dementia/ 1266 9 exp diffuse lewy body disease/ 6939

10 mental deterioration/ 5145 11 exp presenile dementia/ 656 12 exp senile dementia/ 3463 13 exp "mixed depression and dementia"/ 120 14 exp Cognitive Defect/ 412096 15 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 332538 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw. 16 or/1-15 478213 17 Sleep/ 90929 18 exp Sleep deprivation/ 13927 19 exp Sleep Hygiene/ 420 20 exp Sleep Disorder/ 195869 21 exp Sleep Wake Disorders/ 195869 22 exp sleep disordered breathing/ 35863 23 exp Wakefulness/ 27281 24 (sleep* or Insomnia* or dyssomnia* or somnambul* or wakeful* or somnolence).ti,ab,kw. 250395 25 ((circadian or biological clock) adj6 (disturb* or deprivation or disorder* or difficult* or 8024 disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea)).ti,ab,kw. 26 ((circadian or biological clock) adj6 (treatment* or therap* or intervention* or plan* or 14177 program* or structur* or strateg* or protocol* or hygiene or pattern* or regulation or cycle* or syndrome or quality)).ti,ab,kw. 27 or/17-26 368995 28 exp Sleep medicine/ 3473 29 Sleep/dt 4 30 Sleep Disorder/dt 5125 31 exp sedative agent/ 15932 32 ((sleep* or sedative) adj1 (medicine or medication* or drug* or agent* or pill*)).ti,ab,kw. 8122 33 exp melatonin/ 30308 34 melatonin*.mp. 34071 35 or/28-34 61813 36 16 and 27 and 35 2274 37 limit 36 to (randomized controlled trial or controlled clinical trial) 128 38 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 805527 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 39 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 348967 40 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 211437 41 ((patient* or person* or participant* or population) adj3 (random* or blind* or 185350 mask*)).ti,ab.

42 or/38-41 985247 43 36 and 42 248 44 37 or 43 286 45 limit 44 to (yr="2016-2018" and (danish or english or german or norwegian or swedish)) 45 46 limit 45 to ("systematic review" or review or letter or note) 16 47 45 not 46 29

PICO 4: Bør personer med demens og søvnbesvær og/eller døgnrytmeforstyrrelse behandles med mirtazapin eller mianserin?

Søgt 26.01.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to January 24, 2018 Search Strategy: # Searches Results 1 Dementia/ 43787 2 exp Alzheimer Disease/ 80797 3 exp Aphasia, Primary Progressive/ 633 4 exp Primary Progressive Nonfluent Aphasia/ 94 5 exp Dementia, Vascular/ 6052 6 exp Dementia, Multi-Infarct/ 1082 7 exp Frontotemporal Lobar Degeneration/ 3276 8 exp Frontotemporal Dementia/ 2340 9 exp Lewy Body Disease/ 2664 10 exp Cognitive Dysfunction/ 7049 11 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 229811 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw,kf. 12 or/1-11 247915 13 exp Sleep/ 70554 14 exp Sleep deprivation/ 8584 15 exp Sleep Hygiene/ 62 16 exp Sleep Latency/ 7 17 exp Sleep Wake Disorders/ 76352 18 exp Sleep Apnea Syndromes/ 30207 19 Wakefulness/ 16196 20 (Insomnia or somnambul* or wakeful* or somnolence).ti,ab,kw,kf. 31930 21 ((Sleep* or circadian or biological clock) adj10 (disturb* or deprivation or disorder* or 116792 difficult* or disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea or latency or hygiene or hygiene or pattern* or regulation or cycle* or syndrome or quality or treatment* or therap* or intervention* or plan* or program* or structur* or strateg* or protocol* or guid* or advic* or advis* or support* or diary or diaries)).ti,ab,kw,kf.

22 or/13-21 186522 23 Sleep disorders/dt 2224 24 Sleep/dt, de 9034 25 ((sleep* or sedation or sedate) adj1 (medicine or medication* or drug* or agent* or 3182 pill*)).ti,ab,kw,kf. 26 nassa.ti,ab,kw. 92 27 mianserin/ 2442 28 (mianserin* or mirtazapin*).mp. 4175 29 or/23-28 18128 30 12 and 22 and 29 302 31 limit 30 to (randomized controlled trial or controlled clinical trial) 55 32 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study 556204 or studies or analy*)) or rct).ti,ab,kw,kf. 33 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw. 251460 34 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 154831 35 ((patient* or person*) adj3 (random* or blind* or mask*)).ti,ab. 97691 36 or/32-35 678462 37 30 and 36 73 38 31 or 37 82 39 (systematic reviews or meta analysis).pt. 83922 40 38 not 39 77 41 limit 40 to (danish or english or german or norwegian or swedish) 76

Embase

Database(s): Embase 1974 to 2018 January 25 Search Strategy: # Searches Results 1 Dementia/ 101064 2 exp Alzheimer Disease/ 164505 3 exp primary progressive aphasia/ 2901 4 exp Primary Progressive Nonfluent Aphasia/ 643 5 exp frontotemporal dementia/ 13930 6 exp Dementia, Multi-Infarct/ 10732 7 exp Frontotemporal Lobar Degeneration/ 13930 8 exp pick presenile dementia/ 1256 9 exp diffuse lewy body disease/ 6753 10 mental deterioration/ 5052 11 exp presenile dementia/ 654

12 exp senile dementia/ 3454 13 exp "mixed depression and dementia"/ 119 14 exp Cognitive Defect/ 404853 15 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 325741 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw. 16 15 and (2016* or 2017* or 2018*).em. 73065 17 or/1-14,16 422011 18 exp Sleep/ 202624 19 exp Sleep deprivation/ 13715 20 exp Sleep Hygiene/ 368 21 exp Sleep Disorder/ 192788 22 exp Sleep Wake Disorders/ 192788 23 (Insomnia or somnambul* or wakeful* or somnolence).ti,ab,kw,kf. 51373 24 ((Sleep* or circadian or biological clock) adj10 (disturb* or deprivation or disorder* or 176014 difficult* or disorder* or dysfunction* or disrupt* or abrupt* or reduc* or latency or problem* or apnea or latency or hygiene or hygiene or pattern* or regulation or cycle* or syndrome or quality or treatment* or therap* or intervention* or plan* or program* or structur* or strateg* or protocol* or guid* or advic* or advis* or support* or diary or diaries)).ti,ab,kw. 25 or/18-24 350016 26 nassa.ti,ab,kw. 157 27 exp Sleep medicine/ 3432 28 Sleep/dt 4 29 Sleep Disorder/dt 5089 30 exp sedative agent/ 15820 31 ((sleep* or sedative or sedate) adj1 (medicine or medication* or drug* or agent* or 7982 pill*)).ti,ab,kw. 32 mianserin/ 7536 33 (mianserin* or mirtazapin*).mp. 17678 34 or/26-33 46241 35 17 and 25 and 34 1936 36 limit 35 to (randomized controlled trial or controlled clinical trial) 96 37 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study 757578 or studies or analy*)) or rct).ti,ab,kw. 38 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 344827 39 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 209627 40 ((patient* or person*) adj3 (random* or blind* or mask*)).ti,ab,kw. 148379 41 or/37-40 931519 42 35 and 41 205

43 36 or 42 240 44 limit 43 to ("systematic review" or meta analysis) 42 45 43 not 44 198 46 limit 45 to (danish or english or german or norwegian or swedish) 193

PICO 5: Bør personer med demens i behandling med antidepressiva (> 6 måneder) revurderes med henblik på om behandlingen skal fortsætte eller seponeres?

Søgt 09.03.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March 07 2018 Search Strategy: # Searches Results 1 Dementia/ 44271 2 exp Alzheimer Disease/ 81742 3 exp Aphasia, Primary Progressive/ 649 4 exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ 6084 6 exp Dementia, Multi-Infarct/ 1083 7 exp Frontotemporal Lobar Degeneration/ 3378 8 exp Frontotemporal Dementia/ 2424 9 exp Lewy Body Disease/ 2712 10 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 187925 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/1-10 206466 12 exp Antidepressive Agents/ 134285 13 (anti-depressants or antidepressants or anti depressants).ti,ab,kw,kf. 31140 14 ((anti-depressive or antidepressive or anti-depressant or antidepressant) adj3 (drug* or agent* 14827 or pill*1 or medication* or medicine)).ti,ab,kw,kf. 15 (Noradrenergic adj Specific adj Serotonergic adj Antidepressant*).ti,ab,kw. 1 16 nassa.ti,ab,kw,kf. 92 17 mianserin/ 2451 18 (mianserin* or mirtazapin*).mp. 4189 19 Serotonin Uptake Inhibitors/ 18101 20 (Selective Serotonin Reuptake Inhibitor* or SSRI* or 5-Hydroxytryptamine Uptake Inhibitor* or 16259 5 Hydroxytryptamine Uptake Inhibitor* or 5-HT Uptake Inhibitor* or 5 HT Uptake Inhibitor* or Serotonin Reuptake Inhibitor* or Serotonin Uptake Inhibitor*).ti,ab,kw,kf. 21 (citalopram* or escitalopram* or fluoxetin* or fluvoxamin* or paroxetin* or sertralin*).mp. 26849 22 exp "Serotonin and Noradrenaline Reuptake Inhibitors"/ 3843 23 (serotonin and (noradrenalin or norepinephrine)).ti,ab,kw,kf. 8920 24 (serotonin-norepinephrine or serotonin-noradrenalin).ti,ab,kw,kf. 1438 25 (SNRI* or NSRI*).ti,ab,kw,kf. 1161

26 (duloxetin* or milnacipram* or venlafaxin*).mp. 5853 27 Antidepressive Agents, Tricyclic/ 10060 28 (tca or Amitriptylin* or Imipramin* or Nortriptylin* or Clomipramin* or desipramin* or 42163 Maprotilin* or dosulepin* or Dothiepin* or Doxepin* or lofepramin* or protriptylin* or trimipramin* or amoxapin* or desvenlafaxin* or levomilnacipran* or vortioxetin*).mp. 29 (tricyclic or tri-cyclic).ti,ab,kw,kf. 14845 30 (MAOI* or izocarboxazid* or phenelzin* or tranylcipromin* or brofaramin* or moclobemid* or 3349 tyrima).mp. 31 (NARI or NARIs or reboxetin* or NDRI* or amineptin* or buproprion*).mp. 1794 32 (SARI or SARIs or trazodon* or agomelatin* or vilazodon*).mp. 3255 33 or/12-32 184976 34 exp Withholding Treatment/ 14038 35 Substance Withdrawal Syndrome/ 20348 36 Deprescriptions/ 126 37 (discontinu* or deprescrib* or deprescrip* or withdraw* or with-draw* or taper* or 293562 cessat*).ti,ab,kw,kf. 38 ((withhold* or with-hold* or withheld* or with-held* or stop* or pause* or end*3) adj4 (treat* 65479 or therap* or prescrib* or prescription* or drug* or medication* or medicine or antidepressant* or anti-depressant*)).ti,ab,kw,kf. 39 or/34-38 366248 40 11 and 33 and 39 190 41 limit 40 to (randomized controlled trial or controlled clinical trial) 18 42 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 586575 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 43 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 252305 44 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155766 45 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 125371 46 or/42-45 714309 47 40 and 46 47 48 41 or 47 50 49 limit 48 to (danish or english or german or norwegian or swedish) 46 50 (systematic reviews or review).pt. 2351807 51 49 not 50 25

Embase

Database(s): Embase 1974 to 2018 March 08 Search Strategy: # Searches Results 1 Dementia/ 102257 2 exp Alzheimer Disease/ 168037 3 exp primary progressive aphasia/ 2969 4 exp Primary Progressive Nonfluent Aphasia/ 660 5 exp frontotemporal dementia/ 14235 6 exp multiinfarct dementia/ 10857 7 exp Frontotemporal Lobar Degeneration/ 14235 8 exp mental deterioration/ 5126 9 exp diffuse Lewy body disease/ 6933 10 exp "mixed depression and dementia"/ 120 11 exp Pick presenile dementia/ 1264 12 presenile dementia/ 656 13 exp senile dementia/ 3461 14 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 265339 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw. 15 or/1-14 316400 16 exp antidepressant agent/ 403195 17 (anti-depressants or antidepressants or anti depressants).ti,ab,kw. 47502 18 ((anti-depressive or antidepressive or anti-depressant or antidepressant) adj3 (drug* or agent* 20187 or pill*1 or medication* or medicine)).ti,ab,kw. 19 (Noradrenergic adj Specific adj Serotonergic adj Antidepressant*).ti,ab,kw. 3 20 nassa.ti,ab,kw. 157 21 mianserin/ 7555 22 (mianserin* or mirtazapin*).mp. 17797 23 exp serotonin uptake inhibitor/ 235021 24 (Selective Serotonin Reuptake Inhibitor* or SSRI* or 5-Hydroxytryptamine Uptake Inhibitor* or 25002 5 Hydroxytryptamine Uptake Inhibitor* or 5-HT Uptake Inhibitor* or 5 HT Uptake Inhibitor* or Serotonin Reuptake Inhibitor* or Serotonin Uptake Inhibitor*).ti,ab,kw. 25 (citalopram* or escitalopram* or fluoxetin* or fluvoxamin* or paroxetin* or sertralin*).mp. 80238 26 exp serotonin noradrenalin reuptake inhibitor/ 158178 27 (serotonin and (noradrenalin or norepinephrine)).ti,ab,kw. 11413 28 (serotonin-norepinephrine or serotonin-noradrenalin).ti,ab,kw. 2050 29 (SNRI* or NSRI*).ti,ab,kw. 2310 30 (duloxetin* or milnacipram* or venlafaxin*).mp. 25373 31 exp tricyclic antidepressant agent/ 108223

32 (tca or Amitriptylin* or Imipramin* or Nortriptylin* or Clomipramin* or desipramin* or 103675 Maprotilin* or dosulepin* or Dothiepin* or Doxepin* or lofepramin* or protriptylin* or trimipramin* or amoxapin* or desvenlafaxin* or levomilnacipran* or vortioxetin*).mp. 33 (tricyclic or tri-cyclic).ti,ab,kw. 20753 34 (MAOI* or izocarboxazid* or phenelzin* or tranylcipromin* or brofaramin* or moclobemid* or 10066 tyrima).mp. 35 (NARI or NARIs or reboxetin* or NDRI* or amineptin* or buproprion*).mp. 5090 36 (SARI or SARIs or trazodon* or agomelatin* or vilazodon*).mp. 14605 37 or/16-36 437912 38 exp treatment withdrawal/ 169157 39 drug withdrawal/ 155378 40 exp Deprescription/ 130 41 exp withdrawal syndrome/ 31050 42 (discontinu* or deprescrib* or deprescrip* or withdraw* or with-draw* or taper* or 411733 cessat*).ti,ab,kw. 43 ((withhold* or with-hold* or withheld or with-held* or stop* or pause* or end*3) adj4 (treat* 104722 or therap* or prescrib* or prescription* or drug* or medication* or medicine or antidepressant* or anti-depressant*)).ti,ab,kw. 44 or/38-43 625841 45 15 and 37 and 44 1488 46 limit 45 to (randomized controlled trial or controlled clinical trial) 129 47 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 805142 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 48 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 348890 49 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 211396 50 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 185271 51 or/47-50 984811 52 45 and 51 265 53 46 or 52 302 54 limit 53 to (danish or english or german or norwegian or swedish) 296 55 limit 54 to ("systematic review" or review or letter or note) 125 56 54 not 55 171

PsycINFO

Database(s): PsycINFO 1806 to March Week 1 2018 Search Strategy: # Searches Results 1 exp Dementia/ 68788 2 exp Neurodegenerative Diseases/ 69825 3 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 91821

(Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,id. 4 or/1-3 115011 5 exp Antidepressant Drugs/ 36326 6 (anti-depressants or antidepressants or anti depressants).ti,ab,id. 20067 7 ((anti-depressive or antidepressive or anti-depressant or antidepressant) adj3 (drug* or agent* 9584 or pill*1 or medication* or medicine)).ti,ab,id. 8 (Noradrenergic adj Specific adj Serotonergic adj Antidepressant*).ti,ab,id. 0 9 nassa.ti,ab,id. 43 10 mianserin/ 347 11 (mianserin* or mirtazapin*).mp. 1861 12 exp Serotonin Reuptake Inhibitors/ 11749 13 (Selective Serotonin Reuptake Inhibitor* or SSRI* or 5-Hydroxytryptamine Uptake Inhibitor* or 10547 5 Hydroxytryptamine Uptake Inhibitor* or 5-HT Uptake Inhibitor* or 5 HT Uptake Inhibitor* or Serotonin Reuptake Inhibitor* or Serotonin Uptake Inhibitor*).ti,ab,id. 14 (citalopram* or escitalopram* or fluoxetin* or fluvoxamin* or paroxetin* or sertralin*).mp. 14291 15 exp Serotonin Norepinephrine Reuptake Inhibitors/ 1562 16 (serotonin and (noradrenalin or norepinephrine)).ti,ab,id. 3179 17 (serotonin-norepinephrine or serotonin-noradrenalin).ti,ab,id. 801 18 (SNRI* or NSRI*).ti,ab,id. 674 19 (duloxetin* or milnacipram* or venlafaxin*).mp. 3049 20 exp Tricyclic Antidepressant Drugs/ 6301 21 (tca or Amitriptylin* or Imipramin* or Nortriptylin* or Clomipramin* or desipramin* or 11411 Maprotilin* or dosulepin* or Dothiepin* or Doxepin* or lofepramin* or protriptylin* or trimipramin* or amoxapin* or desvenlafaxin* or levomilnacipran* or vortioxetin*).mp. 22 (tricyclic or tri-cyclic).ti,ab,id. 5067 23 (MAOI* or izocarboxazid* or phenelzin* or tranylcipromin* or brofaramin* or moclobemid* or 1602 tyrima).mp. 24 (NARI or NARIs or reboxetin* or NDRI* or amineptin* or buproprion*).mp. 808 25 (SARI or SARIs or trazodon* or agomelatin* or vilazodon*).mp. 1452 26 or/5-25 58321 27 Drug Withdrawal/ 5563 28 Treatment Withholding/ 458 29 Treatment Termination/ 1978 30 (discontinu* or deprescrib* or deprescrip* or withdraw* or with-draw* or taper* or 72914 cessat*).ti,ab,id. 31 ((withhold* or with-hold* or withheld or with-held* or stop* or pause* or end*3) adj4 (treat* 11046 or therap* or prescrib* or prescription* or drug* or medication* or medicine or antidepressant* or anti-depressant*)).ti,ab,id. 32 or/27-31 84082 33 4 and 26 and 32 153 34 (((random* or cluster-random* or crossover or cross-over or blind* or mask*) adj4 (trial*1 or 74094

study or studies or analy*)) or rct).ti,ab,id. 35 (placebo* or single-blind* or double-blind* or triple-blind* or ((single or double or triple) adj 45149 (blind* or mask*))).ti,ab,id. 36 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 20012 37 or/34-36 108742 38 33 and 37 27 39 limit 38 to (danish or english or german or norwegian or swedish) 26

PICO 6: Bør behandling med urologiske spasmolytika med antikolinerg virkning undlades hos personer med demens?

Søgt 13.03.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March 07 2018 Search Strategy: # Searches Results 1 Dementia/ 44287 2 exp Alzheimer Disease/ 81768 3 exp Aphasia, Primary Progressive/ 649 4 exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ 6086 6 exp Dementia, Multi-Infarct/ 1083 7 exp Frontotemporal Lobar Degeneration/ 3381 8 exp Frontotemporal Dementia/ 2427 9 exp Lewy Body Disease/ 2712 10 exp Cognitive Dysfunction/ 7749 11 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 232645 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw,kf. 12 or/1-11 250890 13 exp Urinary Incontinence/dt 2037 14 exp Urinary Bladder, Overactive/dt 1704 15 (Antimuscarinic* or anti-muscarinic* or (anti adj muscarinic*) or (muscarinic* adj3 3028 blocking)).ti,ab,kw,kf. 16 (urin* adj6 spasmolyt*).ti,ab,kw,kf. 18 17 exp Urological Agents/ 27410 18 solifenacin/ 332 19 tolterodine/ 620 20 (darifenacin* or fesoterodin* or oxybutynin* or solifenacin* or tolterodin* or trospium or 4425 trospiumchlorid* or trospium chlorid* or trospium-chlorid* or tamsulosin*).mp. 21 or/13-20 35035

22 (incontinence or bladder or pelvic* or urin* or luts).mp. 691623 23 (drug* or agent* or medication* or medicine or pill*).mp. 4888322 24 (21 and 22) or (22 and 23) 145544 25 or/13-20,24 173429 26 12 and 25 1160 27 limit 26 to (randomized controlled trial or controlled clinical trial) 95 28 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 587344 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 29 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 252539 30 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155902 31 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 125519 32 or/28-31 715173 33 26 and 32 172 34 27 or 33 184 35 limit 34 to (yr="2015-2018" and (danish or english or german or norwegian or swedish)) 30 36 limit 35 to (systematic reviews or review) 8 37 35 not 36 22

Embase

Database(s): Embase 1974 to 2018 March 12 Search Strategy: # Searches Results 1 Dementia/ 102354 2 exp Alzheimer Disease/ 168185 3 exp primary progressive aphasia/ 2971 4 exp Primary Progressive Nonfluent Aphasia/ 661 5 exp frontotemporal dementia/ 14251 6 exp Multiinfarct Dementia/ 10865 7 exp Frontotemporal Lobar Degeneration/ 14251 8 exp pick presenile dementia/ 1266 9 exp diffuse lewy body disease/ 6939 10 mental deterioration/ 5145 11 exp presenile dementia/ 656

12 exp senile dementia/ 3463 13 exp "mixed depression and dementia"/ 120 14 exp Cognitive Defect/ 412183 15 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 332628 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw. 16 or/1-15 478316 17 exp Urine Incontinence/dt, si 7386 18 exp Overactive Bladder/dt, si 3707 19 exp urinary tract disease/dt, si 222129 20 exp muscarinic receptor blocking agent/ 109481 21 exp urinary tract spasmolytic agent/ 102231 22 (urin* adj6 spasmolyt*).ti,ab,kw. 27 23 (Antimuscarinic* or anti-muscarinic* or (anti adj muscarinic*) or (muscarinic* adj3 4480 blocking)).ti,ab,kw. 24 darifenacin/ 1305 25 fesoterodine/ 789 26 oxybutynin/ 5461 27 solifenacin/ 2003 28 tolterodine/ 3532 29 tamsulosin/ 5433 30 trospium chloride/ 1379 31 (darifenacin* or fesoterodin* or oxybutynin* or solifenacin* or tolterodin* or trospium or 13815 trospiumchlorid* or trospium chlorid* or trospium-chlorid* or tamsulosin*).mp. 32 or/17-31 395733 33 (incontinence or bladder or urinary or luts).ti,ab,kw. 519342 34 (drug* or agent* or medication* or medicine or pill*).ti,ab,kw. 3677625 35 (33 and 32) or (33 and 34) 107107 36 or/17-31,35 452870 37 16 and 36 11723 38 limit 37 to (randomized controlled trial or controlled clinical trial) 783 39 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 805761 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 40 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 349063 41 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 211490

42 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 185412 43 or/39-42 985529 44 37 and 43 1305 45 38 or 44 1583 46 limit 45 to (yr="2015-2018" and (danish or english or german or norwegian or swedish)) 253 47 limit 46 to ("systematic review" or review or letter or note) 53 48 46 not 47 200

Supplerende søgning på observationelle studier

Søgt 18.04.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to April 11 2018 Search Strategy: # Searches Results 1 Dementia/ 44685 2 exp Alzheimer Disease/ 82437 3 exp Aphasia, Primary Progressive/ 657 4 exp Primary Progressive Nonfluent Aphasia/ 96 5 exp Dementia, Vascular/ 6108 6 exp Dementia, Multi-Infarct/ 1083 7 exp Frontotemporal Lobar Degeneration/ 3435 8 exp Frontotemporal Dementia/ 2473 9 exp Lewy Body Disease/ 2743 10 exp Cognitive Dysfunction/ 8218 11 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 235191 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw,kf. 12 or/1-11 253544 13 exp Urinary Incontinence/dt 2043 14 exp Urinary Bladder, Overactive/dt 1717 15 (Antimuscarinic* or anti-muscarinic* or (anti adj muscarinic*) or (muscarinic* adj3 3049 blocking)).ti,ab,kw,kf. 16 (urin* adj6 spasmolyt*).ti,ab,kw,kf. 18 17 exp Urological Agents/ 27478 18 solifenacin/ 334 19 tolterodine/ 622 20 (darifenacin* or fesoterodin* or oxybutynin* or solifenacin* or tolterodin* or trospium or 4455 trospiumchlorid* or trospium chlorid* or trospium-chlorid* or tamsulosin*).mp. 21 or/13-20 35142 22 (incontinence or bladder or pelvic* or urin* or luts).mp. 694967 23 (drug* or agent* or medication* or medicine or pill*).mp. 4915580 24 (21 and 22) or (22 and 23) 146320 25 or/13-20,24 174272 26 12 and 25 1173

27 limit 26 to (comparative study or evaluation studies or multicenter study or observational 150 study or twin study or validation studies) 28 exp Epidemiologic studies/ 2146587 29 ((Epidemiolog* or cohort* or perspective or prospective or longitud* or follow-up or follow 1489707 up or followup or retro-spective or retrospective or case-control* or case control* or observational or cross-section* or cross section* or multi-cent* or multicent* or evaluation or comparative or intervention or provoca* or validation) adj3 (study or studies or trial*1 or analys*)).ti,ab,kw,kf. 30 or/28-29 2850215 31 26 and 30 292 32 27 or 31 367 33 limit 32 to (yr="2015-2018" and (danish or english or german or norwegian or swedish)) 92 34 limit 33 to (systematic reviews or review or randomized controlled trial) 10 35 33 not 34 82

Embase

Database(s): Embase 1974 to 2018 April 17 Search Strategy: # Searches Results 47 Dementia/ 104361 48 exp Alzheimer Disease/ 174298 49 exp primary progressive aphasia/ 3079 50 exp Primary Progressive Nonfluent Aphasia/ 694 51 exp frontotemporal dementia/ 14739 52 exp Multiinfarct Dementia/ 11196 53 exp Frontotemporal Lobar Degeneration/ 14739 54 exp pick presenile dementia/ 1309 55 exp diffuse lewy body disease/ 7153 56 mental deterioration/ 5289 57 exp presenile dementia/ 662 58 exp senile dementia/ 3514 59 exp "mixed depression and dementia"/ 125 60 exp Cognitive Defect/ 422028 61 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 342105 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw. 62 or/47-61 489524

63 exp Urine Incontinence/dt, si 7431 64 exp Overactive Bladder/dt, si 3752 65 exp muscarinic receptor blocking agent/ 110184 66 exp urinary tract spasmolytic agent/ 102699 67 (urin* adj6 spasmolyt*).ti,ab,kw. 27 68 (Antimuscarinic* or anti-muscarinic* or (anti adj muscarinic*) or (muscarinic* adj3 4516 blocking)).ti,ab,kw. 69 darifenacin/ 1311 70 fesoterodine/ 801 71 oxybutynin/ 5494 72 solifenacin/ 2031 73 tolterodine/ 3554 74 tamsulosin/ 5490 75 trospium chloride/ 1381 76 (darifenacin* or fesoterodin* or oxybutynin* or solifenacin* or tolterodin* or trospium or 13944 trospiumchlorid* or trospium chlorid* or trospium-chlorid* or tamsulosin*).mp. 77 or/63-76 190201 78 (incontinence or bladder or urinary or luts).ti,ab,kw. 524550 79 (drug* or agent* or medication* or medicine or pill*).ti,ab,kw. 3718108 80 (78 and 77) or (78 and 79) 82820 81 or/63-76,80 257841 82 62 and 81 8331 83 limit 82 to multicenter study 99 84 Observational study/ or Multicenter study/ or Evaluation study/ or exp comparative study/ 4004646 or exp case control study/ or intervention study/ or exp longitudinal study/ or prospective study/ or retrospective study/ or Follow up/ or validation study/ or cohort analysis/ or cross-sectional study/ or crossover procedure/ 85 ((Epidemiologic or cohort* or perspective or prospective or longitud* or follow-up or follow 2029560 up or followup or retro-spective or retrospective or case-control* or case control* or observational or cross-section* or cross section* or multi-cent* or multicent* or evaluation or comparative or intervention or provoca* or validation) adj3 (study or studies or trial*1 or analys*)).ti,ab,kw. 86 or/84-85 4699364 87 82 and 86 1569 88 83 or 87 1569 89 limit 88 to (yr="2015-2018" and (danish or english or german or norwegian or swedish)) 412 90 limit 89 to ("systematic review" or review or letter or note or randomized controlled trial) 69 91 89 not 90 343

PICO 7: Bør man forsøge seponering af paracetamol ved usikker indikation hos personer med demens?

Søgt 14.03.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March 07 2018 Search Strategy: # Searches Results 1 Dementia/ 44305 2 exp Alzheimer Disease/ 81778 3 exp Aphasia, Primary Progressive/ 650 4 exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ 6086 6 exp Dementia, Multi-Infarct/ 1083 7 exp Frontotemporal Lobar Degeneration/ 3387 8 exp Frontotemporal Dementia/ 2433 9 exp Lewy Body Disease/ 2712 10 exp Cognitive Dysfunction/ 7760 11 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 232777 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder).ti,ab,kw,kf. 12 or/1-11 251027 13 exp Acetaminophen/ 16424 14 (Paracetamol or Acetaminophen).mp. 25213 15 or/13-14 25213 16 12 and 15 128 17 limit 16 to (randomized controlled trial or controlled clinical trial) 13 18 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 587713 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 19 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 252625 20 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155958 21 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 125606 22 or/18-21 715579 23 16 and 22 29 24 17 or 23 30 25 limit 24 to (danish or english or german or norwegian or swedish) 30

Embase

Database(s): Embase 1974 to 2018 March 13 Search Strategy: # Searches Results 1 Dementia/ 102371 2 exp Alzheimer Disease/ 168266 3 exp primary progressive aphasia/ 2973 4 exp Primary Progressive Nonfluent Aphasia/ 662 5 exp frontotemporal dementia/ 14257 6 exp Multiinfarct Dementia/ 10866 7 exp Frontotemporal Lobar Degeneration/ 14257 8 exp pick presenile dementia/ 1266 9 exp diffuse lewy body disease/ 6942 10 mental deterioration/ 5145 11 exp presenile dementia/ 656 12 exp senile dementia/ 3463 13 exp "mixed depression and dementia"/ 120 14 exp Cognitive Defect/ 412344 15 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 333899 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder*).ti,ab,kw. 16 or/1-15 479047 17 exp paracetamol/ 80012 18 (Paracetamol or Acetaminophen).mp. 85183 19 or/17-18 85187 20 16 and 19 1557 21 limit 20 to (randomized controlled trial or controlled clinical trial) 97 22 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 806400 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 23 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 349274 24 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 211611 25 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 185592 26 or/22-25 986270 27 20 and 26 156 28 21 or 27 189 29 limit 28 to (danish or english or german or norwegian or swedish) 185

Cinahl

# Query Limiters/Expanders Results

S11 S3 AND S6 AND S10 Limiters - Language: Danish, 10 English, German, Norwegian, Swedish

S10 S7 OR S8 OR S9 163,346

S9 (placebo* or single-blind* or double-blind* or triple- 75,523 blind* or ((single or double or triple) N1 (blind* or mask*)) OR ((patient* or person* or participant* or population) N3 (random* or blind* or mask*))

S8 (((random* or cluster-random* or control#ed or 145,678 crossover or cross-over or blind* or mask*) N4 (trial* or study or studies or analy*)) or rct)

S7 PT (Randomized Controlled Trial) 43,154

S6 S4 OR S5 4,290

S5 (Paracetamol or Acetaminophen) 4,290

S4 (MH "Acetaminophen+") 3,150

S3 S1 OR S2 51,563

S2 (dementia* or alzheimer* or (Primary N3 Progressi* 50,674 N3 aphasia) or (Frontotemporal N3 (Degeneration or neurodegeneration)) or lewy-body or lewy- bodies or (lewy N2 (body or bodies)) or (Parkinson* N4 dementia) or BPSD or PDD or FTD or DLB or Mental Deterioration* or (cognitive adj2 (impairment* or dysfunction* or decline)) or Neurocognitive Disorder*)

S1 (MH "Dementia+") OR (MH "Cognitive 43,068 Dysfunction+")

PICO 8: Bør man forsøge seponering af opioider ved usikker indikation hos personer med demens?

Søgt 30.01.2018

Medline

27 H8A007M585.rn. 248 28 (opioid* or opiat* or morphin* or codein* or Pethidin* or Meperidine or Ketobemidon* or 152142 hydromorphon* or oxycodon* or fentanyl or buprenorphin* or tramadol or tapentadol or Alfentanil* or methadon* or Remifentanil* or Sufentanil* or Nalbuphin*).ti,ab,kw,kf. 29 or/13-28 177164 30 12 and 29 1060 31 limit 30 to randomized controlled trial 78 32 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or 557619 studies or analy*)) or rct).ti,ab,kw,kf. 33 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw,kf. 251927 34 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 155086 35 ((patient* or person* or participant*) adj3 (random* or blind* or mask*)).ti,ab. 118581 36 or/32-35 688068 37 30 and 36 130 38 31 or 37 153 39 limit 38 to (danish or english or german or norwegian or swedish) 145

Embase

Database(s): Embase 1974 to 2018 February 07 Search Strategy: # Searches Results 1 Dementia/ 101273 2 exp Alzheimer Disease/ 165005 3 exp primary progressive aphasia/ 2907 4 exp Primary Progressive Nonfluent Aphasia/ 645 5 exp multiinfarct dementia/ 10758 6 exp Frontotemporal Lobar Degeneration/ 13985 7 exp Frontotemporal Dementia/ 13985 8 exp pick presenile dementia/ 1258 9 exp presenile dementia/ 654 10 exp senile dementia/ 3454 11 mental deterioration/ 5071 12 exp diffuse lewy body disease/ 6791 13 exp "mixed depression and dementia"/ 120 14 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 261693 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB or mental deterioration).ti,ab,kw. 15 or/1-14 312037

16 exp opiate agonist/ 326708 17 exp narcotic analgesic agent/ 298454 18 Morphine/ 96239 19 Alfentanil/ 6454 20 Codeine/ 19447 21 Fentanyl/ 56093 22 Meperidine/ 22473 23 hydromorphone/ 8354 24 Oxycodone/ 14403 25 Buprenorphine/ 14530 26 Tramadol/ 17473 27 Methadone/ 29321 28 Sufentanil/ 8148 29 Nalbuphine/ 2861 30 Remifentanil/ 11452 31 Tapentadol/ 1155 32 (opioid* or opiat* or morphin* or codein* or Pethidin* or Meperidine or Ketobemidon* or 202995 hydromorphon* or oxycodon* or fentanyl or buprenorphin* or tramadol or tapentadol or Alfentanil* or methadon* or Remifentanil* or Sufentanil* or Nalbuphin*).ti,ab,kw. 33 or/16-32 429699 34 15 and 33 3790 35 limit 34 to randomized controlled trial 60 36 (((random* or control?ed or crossover or cross-over or blind* or mask*) adj3 (trial*1 or study or 760033 studies or analy*)) or rct).ti,ab,kw. 37 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab,kw. 346204 38 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 210099 39 ((patient* or person* or participant*) adj3 (random* or blind* or mask*)).ti,ab. 175655 40 or/36-39 944838 41 34 and 40 171 42 35 or 41 189 43 limit 42 to (danish or english or german or norwegian or swedish) 185

PICO 9: Bør behandlingsmålet for blodtryk være højere hos personer med moderat til svær demens > 80år?

Søgt 21.03.2018

Medline

Database(s): Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE and Versions(R) 1946 to March 14 2018 Search Strategy: # Searches Results 1 Dementia/ 44331 2 exp Alzheimer Disease/ 81781 3 exp Aphasia, Primary Progressive/ 649 4 exp Primary Progressive Nonfluent Aphasia/ 95 5 exp Dementia, Vascular/ 6090 6 exp Dementia, Multi-Infarct/ 1083 7 exp Frontotemporal Lobar Degeneration/ 3387 8 exp Frontotemporal Dementia/ 2435 9 exp Lewy Body Disease/ 2712 10 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal adj3 188363 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw,kf. 11 or/1-10 206919 12 exp Blood Pressure/ 274266 13 exp Hypertension/ 237789 14 (hypertentive or hypertension or hypertensic or (blood adj2 pressure) or antihyperten* or 546709 anti-hyperten*).ti,ab,kw,kf. 15 or/12-14 710497 16 exp Antihypertensive Agents/ 243192 17 exp Hypertension/dt 62272 18 exp Angiotensin-Converting Enzyme Inhibitors/ 41452 19 exp Angiotensin II Type 1 Receptor Blockers/ 15544 20 exp Angiotensin Receptor Antagonists/ 20806 21 Angiotensin II/ai 2810 22 exp Adrenergic beta-Antagonists/ 80702 23 exp Adrenergic alpha-Antagonists/ 48614 24 exp Diuretics/ 76484 25 exp Calcium Channel Blockers/ 77977 26 ((angiotensin adj2 receptor antagonist*) or (angiotensin adj2 receptor block*) or "AT 2 342431 receptor block*" or "AT 2 receptor antagon*" or ARB or ARBs or acei or ace-I or (ace adj2

inhibitor*) or "adrenergic beta antagonist*" or "adrenergic alpha antagonist*" or "beta block*" or "alpha block*" or diuretic* or "calcium channel blocker*" or CCB or CCBs or chlorothiazide or chlorthalidone or hydralazine or hydrochlorothiazide or minoxidil or captopril or enalapril or fosinopril or lisinopril or ramipril or losartan or irbesartan or candesartan or eprosartan or valsartan or olmesartan or telmisartan or amlodipine or diltiazem or felodipine or nicardipine or nifedipine or nimodipine or verapamil or alprenolol or atenolol or metoprolol or nadolol or oxprenolol or pindolol or propranolol or labetalol or prazosin or spironolactone or triamterene or bumetanide or furosemide or indapamide or frusemide or diazoxide or eplerenone or amiloride or clonidine or methyldopa or isradipine or xipamide or barnidipine or lacidipine or aranidipine or azelnidipine or benidipine or clevidipine or darodipine or efonidipine or manidipine or niguldipine or nilvadipine or nisoldipine or nitrendipine or oxodipine or pranidipine or zofenopril or imidapril or cilazapril or azilsartan or fimasartan or bisoprolol or acebutolol or celiprolol or esmolol or sotalol or ketanserin or urapidil or fentolamin or minoxidil or "magnesium sulphate" or Doxazosin*).mp. 27 ((antihyperten* or anti hyperten* or anti-hyperten* or hypoten* or antihypertonic or anti 47095 hypertonic or anti-hypertonic or "angiotensin converting enzyme inhibitor*") adj6 (treat* or manage* or drug* or pill* or agent* or medication* or medicine or propert* or qualit* or attribute* or plan*)).ti,ab,kw,kf. 28 ((treat* adj3 (target* or goal* or measure* or plan*)) or treat-to-target*).ti,ab,kw,kf. 151682 29 or/16-28 655815 30 11 and 15 and 29 1105 31 limit 30 to (randomized controlled trial or controlled clinical trial) 93 32 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 588188 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw,kf. 33 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 252742 34 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 156010 35 ((patient* or person* or participant* or population) adj3 (random* or blind* or mask*)).ti,ab. 125692 36 or/32-35 716150 37 30 and 36 215 38 31 or 37 238 39 limit 38 to (danish or english or german or norwegian or swedish) 221

Embase

Database(s): Embase 1974 to 2018 March 20 Search Strategy: # Searches Results 1 Dementia/ 102612 2 exp Alzheimer Disease/ 168772 3 exp primary progressive aphasia/ 2982 4 exp Primary Progressive Nonfluent Aphasia/ 663 5 exp frontotemporal dementia/ 14311 6 exp Multiinfarct Dementia/ 10899 7 exp Frontotemporal Lobar Degeneration/ 14311 8 exp pick presenile dementia/ 1275 9 exp diffuse lewy body disease/ 6978 10 mental deterioration/ 5168 11 exp presenile dementia/ 657 12 exp senile dementia/ 3466 13 exp "mixed depression and dementia"/ 120 14 (dementia* or alzheimer* or (Primary adj3 Progressi* adj3 aphasia) or (Frontotemporal 266579 adj3 (Degeneration or neurodegeneration)) or lewy-body or lewy-bodies or (lewy adj2 (body or bodies)) or (Parkinson* adj4 dementia) or BPSD or PDD or FTD or DLB).ti,ab,kw. 15 or/1-14 317856 16 exp Blood Pressure/ 513696 17 exp Hypertension/ 644739 18 (hypertentive or hypertension or hypertensic or (blood adj2 pressure) or antihyperten* or 780579 anti-hyperten*).ti,ab,kw. 19 or/16-18 1197678 20 exp antihypertensive agent/ 652164 21 exp Hypertension/dt 112939 22 exp dipeptidyl carboxypeptidase inhibitor/ 160020 23 exp Angiotensin Receptor Antagonist/ 79860 24 angiotensin II/ 27642 25 alpha adrenergic receptor blocking agent/ 16780 26 beta adrenergic receptor blocking agent/ 120768 27 diuretic agent/ 75770 28 calcium channel blocking agent/ 56321 29 ("angiotensin converting enzyme inhibitor*" or (angiotensin adj2 receptor antagonist*) or 636448 (angiotensin adj2 receptor block*) or "AT 2 receptor block*" or "AT 2 receptor antagon*" or ARB or ARBs or acei or ace-I or (ace adj2 inhibitor*) or "adrenergic beta antagonist*" or "adrenergic alpha antagonist*" or "beta block*" or "alpha block*" or diuretic* or "calcium channel blocker*" or CCB or CCBs or chlorothiazide or chlorthalidone or hydralazine or hydrochlorothiazide or minoxidil or captopril or enalapril or fosinopril or lisinopril or

ramipril or losartan or irbesartan or candesartan or eprosartan or valsartan or olmesartan or telmisartan or amlodipine or diltiazem or felodipine or nicardipine or nifedipine or nimodipine or verapamil or alprenolol or atenolol or metoprolol or nadolol or oxprenolol or pindolol or propranolol or labetalol or prazosin or spironolactone or triamterene or bumetanide or furosemide or indapamide or frusemide or diazoxide or eplerenone or amiloride or clonidine or methyldopa or isradipine or xipamide or barnidipine or lacidipine or aranidipine or azelnidipine or benidipine or clevidipine or darodipine or efonidipine or manidipine or niguldipine or nilvadipine or nisoldipine or nitrendipine or oxodipine or pranidipine or zofenopril or imidapril or cilazapril or azilsartan or fimasartan or bisoprolol or acebutolol or celiprolol or esmolol or sotalol or ketanserin or urapidil or fentolamin or minoxidil or "magnesium sulphate").mp. 30 ((antihyperten* or anti hyperten* or anti-hyperten* or hypoten* or antihypertonic or anti 62370 hypertonic or anti-hypertonic) adj6 (treat* or manage* or drug* or pill* or agent* or medication* or medicine or propert* or qualit* or attribute* or plan*)).ti,ab,kw. 31 ((treat* adj3 (target* or goal* or measure* or plan*)) or treat-to-target*).ti,ab,kw. 227628 32 or/20-31 1124706 33 15 and 19 and 32 3959 34 limit 33 to (randomized controlled trial or controlled clinical trial) 235 35 (((random* or cluster-random* or control?ed or crossover or cross-over or blind* or mask*) 809669 adj4 (trial*1 or study or studies or analy*)) or rct).ti,ab,kw. 36 (placebo* or single-blind* or double-blind* or triple-blind*).ti,ab. 350253 37 ((single or double or triple) adj2 (blind* or mask*)).ti,ab. 212169 38 ((patient* or person* or participant* or population) adj3 (random* or blind* or 186390 mask*)).ti,ab. 39 or/35-38 990023 40 33 and 39 451 41 34 or 40 544 42 limit 41 to (danish or english or german or norwegian or swedish) 516 43 limit 42 to ("systematic review" or review or letter or note) 215 44 42 not 43 301