STING Products
The latest buzz in innate immunity...
STING (stimulator of interferon genes), alternatively known as MPYS, TMEM173, MITA and ERIS, is a key sensor of cytosolic nucleic acids. STING, initially thought to serve solely as an adaptor protein for mediating signaling by cytosolic DNA sensors (CDS), was recently found to be a direct sensor of cyclic dinucleotides (CDNs). Interestingly, a variety of natural variants of human STING (hSTING) have been identified. The presence of nonsynonymous variants of hSTING, some in high frequencies, is indicative of its implicit role in disease. It is important to be aware that variant hSTING alleles differentially respond to CDNs.
InvivoGen is the most cited source of tools to study the STING signaling pathway, providing:
STING Ligands
STING Variants MRP
STING Reporter Cells
More at invivogen.com/sting-products
www.invivogen.com 888.457.5873 INNOVATION WITHIN REACH New From Garland Science JANEWAY’S IMMUNOBIOLOGY NINTH EDITION Kenneth Murphy, Washington University School of Medicine Casey Weaver, hŶŝǀĞƌƐŝƚLJŽĨůĂďĂŵĂĂƚŝƌŵŝŶŐŚĂŵ^ĐŚŽŽůŽĨDĞĚŝĐŝŶĞ Janeway’s Immunobiology is a textbook for students studying immunology at the undergraduate, graduate, and medical school levels. As an introduc- ƚŽƌLJƚĞdžƚ͕ƐƚƵĚĞŶƚƐǁŝůůĂƉƉƌĞĐŝĂƚĞƚŚĞŬ͛ƐĐůĞĂƌǁƌŝƟŶŐĂŶĚŝŶĨŽƌŵĂƟǀĞ ŝůůƵƐƚƌĂƟŽŶƐ͕ǁŚŝůĞĂĚǀĂŶĐĞĚƐƚƵĚĞŶƚƐĂŶĚǁŽƌŬŝŶŐŝŵŵƵŶŽůŽŐŝƐƚƐǁŝůůǀĂůƵĞ its comprehensive scope and depth. Janeway’s Immunobiology presents immunology from a consistent point of view throughout—that of the host’s ŝŶƚĞƌĂĐƟŽŶǁŝƚŚĂŶĞŶǀŝƌŽŶŵĞŶƚĨƵůůŽĨŵŝĐƌŽďĞƐĂŶĚƉĂƚŚŽŐĞŶƐ͘dŚĞEŝŶƚŚ ĚŝƟŽŶŚĂƐďĞĞŶƚŚŽƌŽƵŐŚůLJƌĞǀŝƐĞĚďƌŝŶŐŝŶŐƚŚĞĐŽŶƚĞŶƚƵƉͲƚŽͲĚĂƚĞǁŝƚŚ ƐŝŐŶŝĮĐĂŶƚĚĞǀĞůŽƉŵĞŶƚƐŝŶƚŚĞĮĞůĚ͕ĞƐƉĞĐŝĂůůLJŽŶƚŚĞƚŽƉŝĐŽĨŝŶŶĂƚĞ immunity.
ůƐŽŶĞǁƚŽƚŚĞEŝŶƚŚ ĚŝƟŽŶŝƐĂYƵĞƐƟŽŶĂŶŬĂǀĂŝůĂďůĞƚŽĂĚŽƉƟŶŐ instructors, and the Garland Science Learning System which allows ŝŶƐƚƌƵĐƚŽƌƐƚŽĂƐƐŝŐŶŽŶůŝŶĞƚƵƚŽƌŝĂůƐǁŝƚŚĂƐƐĞƐƐŵĞŶƚƐŽŶƐƉĞĐŝĮĐ ŝŵŵƵŶŽůŽŐLJƚŽƉŝĐƐĂŶĚƌĞǀŝĞǁƚŚĞƉĞƌĨŽƌŵĂŶĐĞŽĨƚŚĞĞŶƟƌĞĐůĂƐƐ͕ĂƐǁĞůů ƉƌŝůϮϬϭϲͻϵϮϴƉƉͻϲϮϭŝůůƵƐ as individual students, via the instructor dashboard. >ŽŽƐĞͲ>ĞĂĨͻϵϳϴͲϬͲϴϭϱϯͲϰϱϱϬͲϯͻΨϵϱ WĂƉĞƌďĂĐŬͻϵϳϴͲϬͲϴϭϱϯͲϰϱϬϱͲϯͻΨϭϵϬ To download a detailed table of contents and a chapter sample, ͲŽŽŬƐĂǀĂŝůĂďůĞĨŽƌƉƵƌĐŚĂƐĞĂŶĚƌĞŶƚĂů please visit www.garlandscience.com/product/isbn/9780815345053 CASE STUDIES IN IMMUNOLOGY SEVENTH EDITION Raif Geha, Harvard Medical School Luigi Notarangelo, Harvard Medical School ĂƐĞ^ƚƵĚŝĞƐŝŶ/ŵŵƵŶŽůŽŐLJ͕^ĞǀĞŶƚŚ ĚŝƟŽŶ is intended for medical students and undergraduate and graduate students in immunology. It ƉƌĞƐĞŶƚƐŵĂũŽƌƚŽƉŝĐƐŽĨŝŵŵƵŶŽůŽŐLJƚŚƌŽƵŐŚĂƐĞůĞĐƟŽŶŽĨĐůŝŶŝĐĂůĐĂƐĞƐ that reinforce and extend the basic science. Each case history is preceded ďLJĞƐƐĞŶƟĂůƐĐŝĞŶƟĮĐĨĂĐƚƐĂďŽƵƚƚŚĞŝŵŵƵŶŽůŽŐŝĐĂůŵĞĐŚĂŶŝƐŵƐŽĨƚŚĂƚ ƐƉĞĐŝĮĐĚŝƐŽƌĚĞƌ͘dŚĞĐĂƐĞƐĚĞŵŽŶƐƚƌĂƚĞŚŽǁŝŵŵƵŶŽůŽŐŝĐĂůƉƌŽďůĞŵƐĂƌĞ deconstructed in the clinic and each one is followed by a concise summary ŽĨƚŚĞĐůŝŶŝĐĂůĮŶĚŝŶŐĂŶĚƋƵĞƐƟŽŶƐǁŚŝĐŚĐĂŶƐĞƌǀĞĂƐĚŝƐĐƵƐƐŝŽŶƉŽŝŶƚƐ͘
dŚĞŬŝŶĐůƵĚĞƐĂƚŽƚĂůŽĨϱϱĐĂƐĞƐĂŶĚĐĂŶďĞƵƐĞĚĂƐĞŝƚŚĞƌĂƐƚĂŶĚͲ alone text, review aid, or as a companion to Janeway’s Immunobiology, EŝŶƚŚ ĚŝƟŽŶ and dŚĞ/ŵŵƵŶĞ^LJƐƚĞŵ͕&ŽƵƌƚŚ ĚŝƟŽŶ. Six new cases have ďĞĞŶĂĚĚĞĚƚŽƚŚŝƐĞĚŝƟŽŶ͗K<ϴĚĞĮĐŝĞŶĐLJ͕ĂĐƟǀĂƚĞĚW/ϯ<ĚĞůƚĂƐLJŶ- ĚƌŽŵĞ͕ŝŶĐƌĞĂƐĞĚƐƵƐĐĞƉƟďŝůŝƚLJƚŽĐĂŶĚŝĚĂŝŶĨĞĐƟŽŶƐ͕>ZĚĞĮĐŝĞŶĐLJ͕dĐĞůů signaling defects, and channelopathies. February 2016 • ϯϱϴƉƉͻϮϱϱŝůůƵƐ WĂƉĞƌďĂĐŬͻϵϳϴͲϬͲϴϭϱϯͲϰϱϭϮͲϭͻΨϱϵ ͲŽŽŬƐĂǀĂŝůĂďůĞĨŽƌƉƵƌĐŚĂƐĞĂŶĚƌĞŶƚĂů To view a list of all the cases and a sample case, please visit Individual e-cases available for purchase www.garlandscience.com/product/isbn/9780815345121 sŝƐŝƚƵƐĂƚƚŚĞŵĞƌŝĐĂŶƐƐŽĐŝĂƟŽŶŽĨ/ŵŵƵŶŽůŽŐŝƐƚƐDĞĞƟŶŐŝŶDĂLJ cellen
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ANNUAL REVIEWS | Connect With Our Experts [email protected] The New BD Accuri™ C6 Plus Flow Cytometer The best of personal flow cytometry just got better.
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