MILLIPLEX Human Cytokine/Chemokine Human Cytokine/Chemokine HUMAN Panel I Panel III (Cat. No. HCYTOMAG-60K) (Cat. No. HCYP3MAG-63K)

Immunology 29 ®

(Cat. No. HCYTMAG-60K-PX29) IMMUNOLOGY HCC-1 / CCL14 ▲ M-CSF 29 (Bulk Cat. No. HCYTMAG60PMX29BK) Human Cytokine/Chemokine/ IL-11 MIG / CXCL9 30 (Cat. No. HCYTMAG-60K-PX30) ♦ Growth Factor Panel A NEW IL-29 / IFNλ1 MIP-3α / CCL20 30 (Bulk Cat. No. HCYTMAG60PMX30BK) ♦ (Cat. No. HCYTA-60K) I-TAC / CXCL11 MIP-3β / CCL19 38 (Cat. No. HCYTMAG-60K-PX38) ♦ LIX / CXCL6 / GCP-2 NAP-2 / CXCL7 ▲ 38 (Cat. No. HCYTA-60K-PX38) 38 (Bulk Cat. No. HCYTMAG60PMX38BK) ♦ Lymphotactin / XCL1 38 (Cat. No. HCYTA-60K-PXBK38) 41 (Cat. No. HCYTMAG-60K-PX41) 48 (Cat. No. HCYTA-60K-PX48) 41 (Bulk Cat. No. HCYTMAG60PMX41BK) 48 (Cat. No. HCYTA-60K-PXBK48) Human Cytokine/Chemokine sCD40L IL-9 ♦ Panel IV sCD40L IL-13 EGF ♦ IL-10 ♦ ♦ ♦ (Cat. No. HCYP4MAG-64K) EGF IL-15 Eotaxin / CCL11 ♦ IL-12 (p40) ♦ ♦ ♦ 20

(Cat. No. HCY4MG-64K-PX20) HUMAN Eotaxin/CCL11 IL-17A/CTLA8 FGF-2 / FGF-basic IL-12 (p70) ♦ ♦ 20 (Bulk Cat. No. HCP4MG64KPX20BK) FGF-2/FGF-basic IL-17E/IL-25 Flt3 Ligand IL-13 ♦ Flt3 Ligand IL-17F ♦ Fractalkine / CX3CL1 IL-15 ♦ BAFF / Blys IL-28B / IFNλ3 Fractalkine/CX3CL1 IL-18 ♦ G-CSF ♦ IL-17A / CTLA8 ♦ BRAK / CXCL14 IL-32α G-CSF ♦ IL-22 ♦ GM-CSF ♦ IP-10 / CXCL10 ♦ CCL28 IL-34 GM-CSF ♦ IL-27 GRO MCP-1 / CCL2 ♦ CXCL16 IL-35 GROα IP-10/CXCL10 ♦ IFNα2 ♦ MCP-3 / CCL7 HCC-4 / CCL16 IL-36β / IL-1F8 IFNα2 ♦ MCP-1/CCL2 ♦ IFNγ ♦ MDC / CCL22 HMGB1 ● IL-37 / IL-1F7 IFNγ ♦ MCP-3/CCL7 IL-1α ♦ MIP-1α / CCL3 ♦ IFNβ IL-38 / IL-1F10 IL-1α ♦ M-CSF ♦ IL-1β ♦ MIP-1β / CCL4 ♦ IL-14 / α-Taxilin MIP-4 / PARC / CCL18 IL-1β ♦ MDC/CCL22 IL-1Ra ♦ PDGF-AA ▲ IL-19 MPIF / CCL23 IL-1RA ♦ MIG/CXCL9 ♦ IL-2 ♦ PDGF-AB / BB ▲ IL-24 YKL40/CHI3L1 ♦ ♦ IL-2 MIP-1α/CCL3 IL-3 ♦ RANTES / CCL5 ♦▲ ♦ ♦ IL-3 MIP-1β/CCL4 IL-4 ♦ TGFα ♦ ♦ Human IL-18 Singleplex IL-4 PDGF-AA IL-5 ♦ TNFα ♦ ♦ ♦ IL-5 PDGF-AB/BB IL-6 ♦ TNFβ / Lymphotoxin-α (Cat. No. HIL18MAG-66K) ♦ ♦▲ ♦ IL-6 RANTES/CCL5 IL-7 ♦ (LTA) ♦ ♦ IL-18 IL-7 TGFα IL-8 / CXCL8 ♦ VEGF-A IL-8/CXCL8 ♦ TNFα ♦ IL-9 TNFβ/Lymphotoxin-α Human High Sensitivity ♦ IL-10 ♦ (LTA) Human Cytokine/Chemokine ♦ T Cell IL-12 (p40) ♦ VEGF-A Panel II (Cat. No. HSTCMAG-28SK) IL-12 (p70) ♦ (Cat. No. HCYP2MAG-62K) 13 (Cat. No. HSTCMAG28SPMX13) ♦ 23 (Cat. No. HCP2MAG-62K-PX23) 13 (Bulk Cat. No. HSTCMAG28PMX13BK) ♦ 23 (Bulk Cat. No. HCP2MAG62KPX23BK) 21 (Cat. No. HSTCMAG28SPMX21) 6Ckine/CCL21/ IL-28A/IFNλ2 21 (Bulk Cat. No. HSTCMAG28PMX21BK) Exodus-2 IL-33/NF-HEV ♦ BCA-1/CXCL13 (mature) Fractalkine / CX3CL1 IL-12 (p70) ♦ ♦ CTACK/CCL27 LIF GM-CSF IL-13 ♦ ENA-78/CXCL5 MCP-2/CCL8 IFNγ IL-17A / CTLA8 ♦ FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. Eotaxin-2/CCL24/ MCP-4/CCL13 IL-1β IL-21 ♦ MPIF-2 MIP-1δ/MIP-5/CCL15 IL-2 IL-23 ♦ Eotaxin-3/CCL26 SCF IL-4 I-TAC / CXCL11 ♦ I-309/CCL1 SDF-1/CXCL12 IL-5 MIP-1α / CCL3 ♦ IL-16 TARC/CCL17 IL-6 MIP-1β / CCL4 ♦ IL-20 TPO IL-7 MIP-3α / CCL20 ♦ ♦ IL-21 TRAIL/TNFSF10 IL-8 / CXCL8 TNFα ♦ IL-23 TSLP IL-10

New! Human Cytokine Panel: Larger and Customizable The MILLIPLEX® Human Cytokine/Chemokine/Growth Factor Panel A combines tests for 48 individual immune factors that previously have not been together in a single panel. For more information, see our Application Note.

Legend key for MILLIPLEX® kits

† Analytes which cannot be plexed ▲ These analytes cannot be plexed with ● Serum/Plasma only together: other analytes in this panel in serum/ ★ Tissue Culture samples only – Active and total plasma ^ Competitive assay format – Free and total ◗ Requires a protease inhibitor during Available for custom premix ♦ Available in Cat. No. listed sample collection ◦ Analyte requires a different sample ▼ ■ Premix panel only Requires sample extraction dilution from others in panel Bulk indicates Space Saver Packaging ** No standard/QC; autoantibody levels  Analyte not detectable in serum are reported as MFIs

sigmaaldrich.com/milliplex | 21 FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® IMMUNOLOGY / IMMUNE RESPONSE

HUMAN 22 |sigmaaldrich.com/milliplex (Cat. No.(Cat. HSTC384-28K) TCell Sensitivity 384-well HumanHigh (Cat. No.(Cat. HSCRMAG-32K) Receptor Human SolubleCytokine Human CD8+TCell No.(Cat. HTH17MAG-14K) Human Th17 17 25 25 21 21 17 14 14 sIL-4R sIL-2Rα sIL-1RII sIL-1RI sGP130 sEGFR/sHER1/ErbB1 sCD30 IL-2 IFNγ Granzyme B Granzyme A GM-CSF sFasL sFAS /TNFRSF6 sCD137/4-1BB/ IL-17A /CTLA8 IL-15 IL-13 IL-12 (p70) IL-10 IL-9 IL-6 IL-5 IL-4 IL-2 IL-1β IFNγ GM-CSF IL-10 IL-8 /CXCL8 IL-7 IL-6 IL-5 IL-4 IL-2 IL-1β IFNγ GM-CSF Fractalkine /CX3CL1

TNFRSF9

(Bulk Cat. No.(Bulk Cat. HSCRMAG32PMX14BK) No.(Cat. HSCRMAG32KPX14) No.(Bulk Cat. HCD8MAG15KPX17BK) No.(Cat. HCD8MAG15K17PMX) No.(Bulk Cat. HT17MAG14PMX25BK) No.(Cat. HT17MG-14K-PX25) No.(Bulk Cat. HSTCMAG384PX21BK) No.(Cat HSTCMAG384-PX21) (Cat. No.(Cat. HCD8MAG-15K) sVEGFR3 /sFlt-4 sVEGFR2 /sKDRsFlk-1 sVEGFR1 /sFlt-1 sTNF RII sTNF RI sRAGE sIL-6R TNFα Perforin MIP-1β /CCL4 MIP-1α /CCL3 IL-13 IL-10 IL-6 IL-5 IL-4 TNFβ/Lymphotoxin-α TNFα MIP-3α /CCL20 IL-33 /NF-HEV IL-31 IL-28A /IFNλ2 IL-27 IL-23 IL-22 IL-21 IL-17F IL-17E /IL-25 TNFα MIP-3α /CCL20 MIP-1β /CCL4 MIP-1α /CCL3 I-TAC /CXCL11 IL-23 IL-21 IL-17A /CTLA8 IL-13 IL-12 (p70) (LTA) (mature) (Cat. No.(Cat. HMMP2MAG-55K) Human MMPPanel 2 No.(Cat. HMMP1MAG-55K) Human MMPPanel 1 No.(Cat. HCMP2MAG-19K) PanelHuman Complement 2 No.(Cat. HCMP1MAG-19K) PanelHuman Complement 1 (Cat. No.(Cat. TGFBMAG-64K-03) Multi-Species TGFβ –3Plex No.(Bulk Cat. TGFBMAG-64K-01BK) No.(Cat. TGFBMAG-64K-01) Singleplex Multi-Species TGFβ – No.(Cat. HTMP2MAG-54K) culture(Cell samples) Human TIMPPanel 2 No.(Cat. HTMP1MAG-54K) (Serum/Plasma samples) Human TIMPPanel 1 NON-CONFIGURABLE KIT MMP-7 MMP-2 MMP-1 MMP-12 MMP-3 C3b C3 C1q C5 C4b C2 Adipsin/Factor D TGFβ2 TGFβ1 TGFβ1 TIMP-2 TIMP-1 TIMP-1 MMP-10 MMP-9 MMP-13 Factor H Factor B C4 Mannose-binding Factor I C9 C5a TGFβ3 TIMP-4 TIMP-3 TIMP-2 Lectin (MBL) ▼ (Cat. No.(Cat. HCYTAAB-17K) Autoantibody Human Cytokine No.(Cat. HAIAB-10K) Autoantibody** Human Autoimmune Immune Response (Cat. No.(Cat. SKINMAG-50K) only) (Skin extracts Human Skin No.(Cat. HSP3MAG-63K) Human SepsisPanel 3 No.(Cat. HSP2MAG-63K) Human SepsisPanel 2 No.(Cat. HSP1MAG-63K) Human SepsisPanel 1 CENP-A (Centromere C1q β2-Glycoprotein CENP-B (Centromere Myeloperoxidase Mi-2 Ku Jo-1 PCNA (Proliferating PL-12 (Alanyl-tRNA Proteinase 3 PM/Sci 100 IL-8/CXCL8 IL-6 IL-1α IFNγ IFNβ G-CSF BAFF/Blys Human Serum ^ Cortisol NGAL/Lipocalin-2 Neutrophil Elastase-2 Lactotransferrin (LTF) IL-8 /CXCL8 IL-1α HSP70 Granzyme B sICAM-1 sFasL sFAS /TNFRSF6 Protein A) Protein B) (MPO) Antigen A) Cell Nuclear Synthetase) Albumin (HSA) (ELA2)

NEW SB/La (Sjögren’s SSA/Ro60 SSA/Ro52 (Sjögren’s Sm Scl-70 RNP/Smith (RNP/ RNP Ribosomal P TNFα IL-22 IL-17F IL-17A/CTLA8 IL-15 IL-12 (p40) IL-10 Thrombospondin-1 Resistin MMP-8 MIP-1β /CCL4 MIP-1α /CCL3 sVCAM-1 PAI-1 (total) MIF Keratin-6 Keratin-1,10 Involucrin antigen B/La) Syndrome-related kDa) antigen A/Ro60 Syndrome-related (Sjögren’s kDa) antigen A/Ro52 Syndrome-related Sm) (Ribonucleoprotein) (TSP-1)

** MILLIPLEX® IMMUNE RESPONSE / METABOLISM / ENDOCRINOLOGY / CVD FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

HUMAN ^

■ (PF4)/CXCL4 (SAP) Factor (PLGF) Factor Myoglobin NGAL/Lipocalin-2 sP-Selectin A Serum Amyloid sVCAM-1 Haptoglobin sL-Selectin 4 Platelet Factor P Serum Amyloid (PTX3) Pentraxin-3 Thrombomodulin (TF) Tissue Factor T (TnT) Troponin FSH GH LH TSH Testosterone T3 T4 LIGHT NT proBNP Oncostatin-M (OSM) Placental Growth I (TnI) Troponin sigmaaldrich.com/milliplex | 23 sigmaaldrich.com/milliplex (MPO) (AGP) Protein (AgRP) Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel Analyte not detectable in serum ADAMTS13 D-dimer GDF15 sICAM-1 Myeloperoxidase Glycoprotein α-1-Acid α-2-Macroglobulin D Adipsin/Factor CRP A Fetuin Fibrinogen  sCD31/sPECAM-1 dPAPP-A sE-Selectin (FST) Follistatin ACTH Agouti-Related CNTF Cortisol Estradiol Progesterone BNP CK-MB CXCL6/GCP-2 CXCL16 Endocan-1 (ESM-1) FABP3 FABP4 Human CVD Panel 2 Human CVD Panel HCVD2MAG-67K) (Cat. No. 3 Human CVD Panel (Acute Phase) HCVD3MAG-67K) (Cat. No. 4 Human CVD Panel HCVD4MAG-67K) (Cat. No. Human PituitaryHuman 1 Panel HPTP1MAG-66K) (Cat.No. Hormone Multi-Species MSHMAG-21K) (Cat. No. Cardiovascular 1 Human CVD Panel HCVD1MAG-67K) (Cat. No.

● ★ ^ ◦  ◗ ★ Polypeptide (PP) Polypeptide Musclin IGFBP5 IGFBP6 IGFBP7 IGF-2 FGF-19 FGF-21 FGF-23 HGF IL-6 Insulin Leptin MCP-1/CCL2 Pancreatic (total)PYY TNFα IL-15 Irisin LIF Myostatin/GDF8 Oncostatin-M (OSM) Osteocrin (OSTN)/ Osteonectin/SPARC IL-18 Jag1 Leptin IL-6 IL-10 ■ ◗ ◗ These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are IGFBP1 IGFBP2 IGFBP3◦ IGFBP4 IGF-1 α-Fetoprotein (AFP) α-Fetoprotein ANGPTL3 ANGPTL4 ANGPTL6 FABP1 Apelin BDNF Erythropoietin (EPO) FABP3 FGF-21 Fractalkine/CX3CL1 FSTL1 IL-6 Amylin Amylin ◗ † (active) Amylin (total) † ◗ C-Peptide (active) Ghrelin GIP (total) GLP-1 † ◗ (active) GLP-1 (total) † ◗ Glucagon CTACK/CCL27 FGF-21 GDF-11 GDF15 GnRH ▲  ◗ ■ ** Human IGF Binding Protein HIGFBMAG-53K) (Cat. No. Human IGF HIGFMAG-52K) (Cat. No. Human Aging Panel 1 Human Aging Panel HAGE1MAG-20K) (Cat. No. Protein Human Liver HLPPMAG-57K) (Cat. No. Human Myokine HMYOMAG-56K) (Cat. No. Human MetabolicHuman Hormone HMHEMAG-34K) (Cat.No. kits ® ▼ Insulin Leptin PAI-1 (total) PAI-1 Resistin Leptin MCP-1/CCL2 NGF TNFα MCP-1/CCL2 NGF (total) PAI-1 Resistin TNFα IgG3 IgG4 IgM

◗ ◗ Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (Cat. No. HGAMMAG-301K) (Cat.No. (Bulk Cat. No. HDIAB34KPMX5BK) (Bulk Cat. No.

(Cat.No. HDIAB-34K-PMX5)

Glucagon C-Peptide (active) GLP-1 Adiponectin HGF IL-1β IL-6 IL-8/CXCL8 Leptin IL-1β IL-6 IL-8/CXCL8 Insulin Adiponectin D Adipsin/Factor NGAL/Lipocalin-2 IgE IgA IgG1 IgG2 NON-CONFIGURABLE KIT 5 5 Human Diabetes (Cell samples) culture HADCYMAG-61K) (Cat. No. Human Adipocyte (Serum/Plasma samples) HADK2MAG-61K) (Cat. No. Human Adipokine Panel 2 Human Adipokine Panel (Serum/Plasma samples) HADK1MAG-61K) (Cat. No. Metabolism/ Endocrinology 1 Panel Human Adipokine Human IgE – Singleplex Human IgE HGAMMAG-303E) (Cat. No. Human Immunoglobulin Immunoglobulin Human Isotyping FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® CVD / BONE / CANCER / NEUROSCIENCE

HUMAN 24 |sigmaaldrich.com/milliplex Bone No.(Cat. APOMAG-62K) Human Apolipoprotein No.(Cat. HCVD6MAG-67K) PanelHuman CVD 6 (Cat. No.(Cat. HCKP2-11K) Checkpoint ProteinPanel 2 Human Immuno-Oncology No.(Cat. HCKP1-11K) Checkpoint ProteinPanel 1 Human Immuno-Oncology Cancer No.(Cat. HRNKLMAG-51K-01) Human RANKL–Singleplex No.(Cat. HBNMAG-51K) Human Bone 17 17 E-Cadherin CD226/DNAM-1 CD137/4-1BB CD40L CD30/TNFRSF8 CD25/IL-2Rα BAFF/BLyS B7-H6 B7-H5/VISTA B7-H4/VTCN1 B7-H3/CD276 B7-H2/ICOSL Arginase-1 APRIL 5’-NT/CD73 4-1BBL/TNFSF9 GITRL GITR CTLA-4/CD152 CD86/B7-2 CD80/B7-1 CD40 CD28 CD27 BTLA RANKL Leptin Insulin IL-6 IL-1β FGF-23 DKK1 ACTH Apo B Apo AII Apo AI LRG1 Endostatin DPP4 sCD14

(Bulk Cat. No.(Bulk Cat. HCKP1-11K-PXBK17) No.(Cat. HCKP1-11K-PX17) Siglec-9 Siglec-7 PVR/CD155 Perforin OX40/CD134 Nectin-4 Nectin-2 MICB MICA IDO1 Granzyme B Granulysin Galectin-3 Galectin-1 FGL1/Hepassocin TLR-2 TIM-3 PD-L2 PD-L1 PD-1 LAG-3 ICOS HVEM TNFα Sclerostin (SOST) PTH Osteoprotegerin (OPG) Osteopontin (OPN) Osteocalcin (OC) Apo E Apo CIII Apo CII ucMGP Progranulin (pGRN) MCAM/MUC18 NEW (Cat. No.(Cat. HCCBP1MAG-58K) Biomarker Panel 1 Human CirculatingCancer No.(Cat. HCABMAG-13K) Autoantibody** Human Cancer (Cat. No.(Cat. HCMBMAG-22K) Biomarker Panel 1 Human Cancer/Metastasis No.(Cat. HCCB4MAG-58K) Biomarker Panel 4 Human CirculatingCancer No.(Cat. HCCBP3MAG-58K) Biomarker Panel 3 Human CirculatingCancer No.(Cat. HCCBP2MAG-58K) Biomarker Panel 2 Human CirculatingCancer IL-6 HGF HE4 HCGβ FGF-2/FGF-basic sFasL sFAS/TNFRSF6 CYFRA21-1 CEA CA19-9 CA15-3 CA125 α-Fetoprotein (AFP) HSP60 HIF-1α HER2/ErbB2 Galectin-3 (GAL3) Galectin-1 (GAL1) ENO1 CTAG1B/NY-ESO-1 CCNB1/Cyclin B1 Osteonectin/SPARC Neuron-specific GDF15 DKK1 Hepsin EpCAM CD44 AnhydraseCarbonic ALDH1A1 IGFBP3 Galectin-3 Fibroblast Activation Ferritin D Cathepsin Complement Factor Antithrombin III Enolase (NSE) 9 (CA9) Protein (FAP) H (CFH) VEGF-A TRAIL/TNFSF10 TNFα TGFα SCF PSA (total)† PSA (free)† Prolactin Osteopontin (OPN) MIF Leptin IL-8/CXCL8 Survivin/BIRC5 SOX2 p53 P16-INK4a Mucin-1 (MUC1) IGF2BP3/IMP3 IGF2BP2/IMP2 YKL40/CHI3L1 TWEAK TRAP5 Periostin Osteoprotegerin Transglutaminase 2 NCAML1/L1CAM/ Midkine Mesothelin Kallikrein-6 Sex HormoneBinding Myeloperoxidase Melanoma Inhibitory DBinding Vitamin Matrix Extracellular (OPG) (TGM2) CD171 Globulin (SHBG) (MPO) (MIA) Activity Protein Protein 1(ECM1) (Cat. No.(Cat. HANG2MAG-12K) Human AngiogenesisPanel 2 No.(Cat. HAGP1MAG-12K) Factor Panel 1 Human Angiogenesis/Growth (Cat. No.(Cat. HNDG1MAG-36K) Disease Panel 1 Human Neurodegenerative No.(Cat. HNS2MAG-95K) Human NeurosciencePanel 2 No.(Cat. HNS1MAG-95K) samples) (CSF Human NeurosciencePanel 1 No.(Cat. HNABTMAG-68K) samples) (CSF Human Amyloid andTau Beta Neuroscience sHGFR/sc-Met sHER3/sEGFR3/ sHER2/sEGFR2/ sEGFR/sHER1/sErbB1 sE-Selectin sc-Kit/sStem Cell sCD31/sPECAM-1 sAXL Angiostatin/Kringle G-CSF Follistatin (FST) FGF-2/FGF-basic FGF-1/FGF-acidic Endothelin-1 Endoglin EGF BMP-9 Angiopoietin-2 Apo E Apo CIII Apo AI α-2-Macroglobulin Ferritin FABP3 ApoE4 Angiogenin (ANG) Neuron-specific Acidic Glial Fibrillary α-Synuclein Amyloid 1-42 beta Amyloid 1-40 beta sErbB3 sErbB2 (SCFR) Factor Receptor Enolase (NSE) Protein (GFAP) ◦ ◦ sVEGFR3/sFlt-4 sVEGFR2/sKDR/sFlk-1 sVEGFR1/sFlt-1 suPAR sTIE-2 Thrombospondin-2 Tenascin-C (TN-C) PDGF-AB/BB Osteopontin (OPN) sNeuropilin-1 (sNRP-1) sIL-6Rα VEGF-D VEGF-C VEGF-A Growth Placental Leptin IL-8/CXCL8 HGF HB-EGF Complement Factor Complement Factor TREM2 PRNP (PrionProtein) Neurogranin (NRGN) Tau (total) pTau (Thr181) Transglutaminase 2 PARK7/DJ1 PARK5/UCHL1 (TSP-2) Factor (PLGF) H (CFH) C3 (TGM2)

MILLIPLEX® NEUROSCIENCE / TOXICITY / IMMUNOLOGY FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

HUMAN / NHP ▼ A) (mature) (LT IL-17E/IL-25 IL-21 IL-22 IL-23 IL-28A/IFNλ2 IL-31 IL-33/NF-HEV IP-10/CXCL10 MIP-3α/CCL20 Perforin RANTES/CCL5 ▲ TNFβ/Lymphotoxin-α TGFβ3 IL-12/23 (p40) IL-12/23 IL-13 IL-15 IL-17A/CTLA8 IL-18 MCP-1/CCL2 MIP-1α/CCL3 MIP-1β/CCL4 TGFα TNFα VEGF-A sigmaaldrich.com/milliplex | 25 sigmaaldrich.com/milliplex β1 (Cat. No. PRCYTOMAG-40K) (Cat.No. (Cat. No. PRCYT2MAG40K) (Cat. No. (Bulk Cat. No. PRCY2MG40PMX25BK) (Bulk Cat. No. (Cat. No. PCYTMG-40K-PX23) (Cat. No. PRCYMAG40PMX23BK) (Bulk Cat. No. PRCYTMAG40K-PX24) (Cat. No. PRCY2MG40PMX24BK) (Bulk Cat. No. PRCYTMAG40K-PX25) (Cat. No.

TNFRSF9 Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel Analyte not detectable in serum

sCD137/4-1BB/ Eotaxin/CCL11 sFasL FGF-2/FGF-basic Fractalkine/CX3CL1 Granzyme A Granzyme B IL-1α IL-2 IL-4 IL-6 IL-16 IL-17A/CTLA8 TGFβ1 TGF TGFβ2 sCD40L G-CSF GM-CSF IFNγ IL-1β IL-1Ra IL-2 IL-4 IL-5 IL-6 IL-8/CXCL8 IL-10 NON-CONFIGURABLE KIT 23 23 25 24 24 25 Multi-Species TGFβ – TGFβ Multi-Species Singleplex TGFBMAG-64K-01) (Cat. No. TGFBMAG-64K-01BK) (Bulk Cat. No. – 3 Plex TGFβ Multi-Species TGFBMAG-64K-03) (Cat. No. PRIMATE Immunology Primate Non-Human Cytokine/Chemokine 1 Panel Non-Human Primate Cytokine/Chemokine 2 Panel

● ★ ^ ◦  Osteoactivin TIMP-1 Uromodulin C Cystatin RBP4 MDH1 SDH Uromodulin Osteopontin (OPN) PTH Renin KIM-1 Osteoactivin Renin TFF-3 TIMP-1 EGF NGAL/Lipocalin-2 Osteopontin (OPN) These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are 5'NT/CD73 ARG1 GSTα α-1-Microglobulin Collagen IV NGAL/Lipocalin-2 β-2-Microglobulin Clusterin β-2-Microglobulin RBP4 EGF FABP1 IP-10/CXCL10 KIM-1 Calbindin Collagen IV FABP1 GSTα IP-10/CXCL10 α-1-Microglobulin Albumin Clusterin C Cystatin ▲  ◗ ■ ** (Cat. No. HLINJMAG-75K) HLINJMAG-75K) (Cat. No. Human Kidney Injury Panel 5 InjuryHuman Kidney Panel (Serum/Plasma samples) HKI5MAG-99K) (Cat. No. 6 InjuryHuman Kidney Panel (Serum/Plasma samples) HKI6MAG-99K) (Cat. No. InjuryHuman Liver Human Kidney Injury Panel 3 InjuryHuman Kidney Panel (Urine samples) HKI3MAG-99K) (Cat. No. 4 InjuryHuman Kidney Panel (Serum/Plasma samples) HKI4MAG-99K) (Cat. No. Human Kidney Injury Panel 2 InjuryHuman Kidney Panel (Urine samples) HKI2MAG-99K) (Cat. No. Toxicity 1 InjuryHuman Kidney Panel (Urine samples) HKI1MAG-99K) (Cat.No. kits ® ^

■ ^

■ Dismutase 1 (sSOD1) Dismutase 2 (sSOD2) (SAP) Melatonin Osteopontin (OPN) Soluble Superoxide Soluble Superoxide Oxytocin Substance P sRAGE S100B MIP-4/PARC/CCL18 PEDF P Serum Amyloid (total) PAI-1 PDGF-AA PDGF-AB/BB RANTES/CCL5 sVCAM-1

◦ Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (AGT) (MPO) Cortisol α-MSH β-Endorphin Neurotensin Kallikrein-6 Angiotensinogen Contactin-1 A Fetuin Amyloid beta 1-40 Amyloid beta 1-42 Amyloid GDNF sNCAM BDNF Cathepsin D sICAM-1 Myeloperoxidase α-1-Antitrypsin (A1AT) α-1-Antitrypsin C4 CRP (Cat. No. HNCSMAG-35K) HNCSMAG-35K) (Cat. No. Human Circadian Stress Human Neuropeptide HNPMAG-35K) (Cat. No. (Cat. No. HND3MAG-39K) (Cat. No. Human Neurological 3 Disorders Panel (Cat. No. HNDG4MAG-36K) (Cat. No. Human Neurodegenerative Human Neurodegenerative 4 Disease Panel (CSF samples) (Cat. No. HNDG3MAG-36K) (Cat. No. Human Neurodegenerative Human Neurodegenerative 3 Disease Panel (Cat. No. HNDG2MAG-36K) (Cat.No. Human Neurodegenerative Neurodegenerative Human 2 Panel Disease FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® METABOLISM / ENDOCRINOLOGY / IMMUNOLOGY

NHP / MOUSE 26 |sigmaaldrich.com/milliplex Panel 1 Non-Human PrimatePituitary No.(Cat. NHPMHMAG-45K) Hormone Metabolic Non-Human Primate Endocrinology Metabolism/ (Cat. No.(Cat. MSHMAG-21K) Multi-Species Hormone■ ^ No.(Cat. NHPPT1MG-46K) Progesterone Estradiol Cortisol CNTF Agouti-Related ACTH IL-6 Glucagon GLP-1 (active) GIP (total) Ghrelin (active) C-Peptide Amylin (active) Protein (AgRP) ◗ ◗ ◗ ◗ T4 T3 Testosterone TSH LH GH FSH PYY (total) Pancreatic MCP-1/CCL2 Leptin Insulin Polypeptide (PP) Panel 1 Mouse Cytokine/Chemokine Immunology MOUSE Mouse High Sensitivity T Cell TCell Mouse HighSensitivity Chemokine Panel 2 Mouse Cytokine/ 32 32 25 25 18 18 15 15 IL-12 (p70) IL-12 (p40) IL-10 IL-9 IL-7 IL-6 IL-5 IL-4 IL-3 IL-2 IL-1β IL-1α IFNγ GM-CSF G-CSF Eotaxin/CCL11 IL-7 IL-6 IL-5 IL-4 IL-2 IL-1β IL-1α IFNγ GM-CSF IL-16 IL-11 IFNγ IFNβ1 Fractalkine/CX3CL1 Exodus-2/ (EPO) Erythropoietin

CCL21/6Ckine (Bulk Cat. No. (BulkCat. MCYTMAG70PMX32BK) No. (Cat. MCYTMAG-70K-PX32)

(Bulk Cat. No.(Bulk Cat. MCYTMAG70PMX25BK) No.(Cat. MCYTOMAG-70K-PMX) (Bulk Cat. No.(Bulk Cat. MHSTCMAG-70KPXBK) No.(Cat. MHSTCMAG-70KPMX) No.(Bulk Cat. MECY2MAG73KPXBK) No.(Cat. MECY2MAG-73KPX) (Cat. No.(Cat. MHSTCMAG-70K) No.(Cat. MECY2MAG-73K) (Cat. No.(Cat. MCYTOMAG-70K) ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ VEGF-A TNFα RANTES/CCL5 MIP-2/CXCL2 MIP-1β/CCL4 MIP-1α/CCL3 MIG/CXCL9 M-CSF MCP-1/CCL2 LIX LIF KC/GRO/CINC-1/ IP-10/CXCL10 IL-17A/CTLA8 IL-15 IL-13 TNFα MIP-2/CXCL2 MCP-1/CCL2 LIX KC/GRO/CINC-1/ IL-17A/CTLA8 IL-13 IL-12 (p70) IL-10 TIMP-1 TARC/CCL17 MIP-3β/CCL19 MIP-3α/CCL20 MDC/CCL22 MCP-5/CCL12 IL-20 IL-17A/F CXCL1 CXCL1 ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ Mouse CD8+TCell Mouse Th17 (Cat. No.(Cat. MMMP3MAG-79K) culture(Cell samples) Mouse MMPPanel 3 No.(Cat. MMMP2MAG-79K) (Serum/Plasma samples) Mouse MMPPanel 2 No.(Cat. MMMP1MAG-79K) (Serum/Plasma samples) Mouse MMPPanel 1 Receptor Mouse SolubleCytokine 15 15 25 25 IL-2 IFNγ Granzyme B GM-CSF sFasL sFas/TNFRSF6 sCD137/4-1BB/ IL-17A/CTLA8 IL-15 IL-13 IL-12 (p70) IL-10 IL-6 IL-5 IL-4 IL-2 IL-1β IFNγ GM-CSF sCD40L MMP-8 MMP-3 MMP-2 proMMP-9 MMP-3 MMP-2 sIL-6R sIL-4R sIL-2Rα sIL-1RII sIL-1RI sGP130 sCD30

TNFRSF9

(Bulk Cat. No.(Bulk Cat. MCD8MAG48KPX15BK) No.(Cat. MCD8MAG48K-PX15) No.(Bulk Cat. MT17MAG47PMX25BK) No.(Cat. MT17MAG47K-PX25) (Cat. No.(Cat. MCD8MAG-48K) No.(Cat. MTH17MAG-47K) (Cat. No.(Cat. MSCRMAG-42K) TNFα RANTES/CCL5 MIP-1β/CCL4 IL-13 IL-10 IL-6 IL-5 IL-4 TNFβ/Lymphotoxin-α TNFα MIP-3α/CCL20 IL-33/NF-HEV IL-31 IL-28B/IFNλ3 IL-27 IL-23 IL-22 IL-21 IL-17F IL-17E/IL-25 MMP-12 proMMP-9 MMP-12 MMP-8 sVEGFR3/sFlt-4 sVEGFR2/sKDR/sFlk-1 sVEGFR1/sFlt-1 sTNF RII sTNF RI sRAGE (LTA) (mature) MILLIPLEX® IMMUNOLOGY / IMMUNE RESPONSE / METABOLISM / ENDOCRINOLOGY / CVD / BONE / CANCER FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

MOUSE (OPG) CXCL1 2 Factor Factor 2 Factor (SAP) Leptin Osteoprotegerin Sclerostin (SOST) TNFα IL-6 IL-17A/CTLA8 KC/GRO/CINC-1/ Leptin MCP-1/CCL2 MIP-1α/CCL3 Placental Growth Prolactin SDF-1/CXCL12 TNFα VEGF-A VEGF-C VEGF-D ProMMP-9 sP-Selectin Thrombomodulin Oncostatin M (OSM) Placental Growth I (TnI) Troponin T (TnT) Troponin CRP Haptoglobin P Serum Amyloid sigmaaldrich.com/milliplex | 27 sigmaaldrich.com/milliplex (AGP) Serum/Plasma only samples only Tissue Culture format assay Competitive Available for custom premix Available sample a different Analyte requires dilution from others in panel Analyte not detectable in serum ACTH DKK1 FGF-23 IL-6 Insulin sALK-1 Amphiregulin Angiopoietin-2 ▲ Betacellulin ▲ sCD31/sPECAM-1 ▲ EGF Endoglin Endothelin-1 sFasL FGF-2/FGF-basic (FST) Follistatin G-CSF HGF IL-1β sCD31/sPECAM-1 sE-Selectin sICAM-1 (total) PAI-1 sCD40L CXCL16 Endocan-1 (ESM-1) (FST) Follistatin LIGHT Glycoprotein α-1-Acid α-2-Macroglobulin D Adipsin/Factor Mouse Bone MBNMAG-41K) (Cat. No. Cancer Mouse Angiogenesis / Growth 1 Panel Factor MAGPMAG-24K) (Cat. No. Cardiovascular 1 Mouse CVD Panel MCVD1MAG-77K) (Cat.No. 2 Mouse CVD Panel MCVD2MAG-77K) (Cat. No. 2 Panel Mouse Acute Phase MAP2MAG-76K) (Cat. No. Bone

● ★ ^ ◦  NEW

Musclin Polypeptide (PP) Polypeptide (PP) Polypeptide NEW Jag1 Leptin Notch1 TNFα LH Prolactin TSH Testosterone T3 T4 Irisin LIF Myostatin/GDF8 Oncostatin-M (OSM) Osteocrin (OSTN)/ Osteonectin/SPARC Leptin MCP-1/CCL2 Pancreatic (total)PYY Resistin TNFα Leptin MCP-1/CCL2 Pancreatic (total)PYY Resistin Secretin TNFα

◗ ◗ ◗ ◗ These analytes cannot be plexed withThese analytes cannot be plexed other analytes in this panel in serum/ plasma a protease inhibitor during Requires sample collection sample extraction Requires No standard/QC; autoantibody levels as MFIs reported are Protein 1 (FSTL1) Cortisol Estradiol Progesterone CTACK/CCL27 FGF-21 GnRH IL-6 ACTH BDNF FSH GH BDNF Erythropoietin (EPO) ★ FGF-21 Follistatin-like Fractalkine/CX3CL1 IL-6 IL-15 Amylin (active) ◗ (active) Amylin 2 C-Peptide ◗ (active) Ghrelin GIP (total) †◗ (active) GLP-1 (total) †◗ GLP-1 Glucagon ◗ IL-6 Insulin (active) Amylin 2 C-Peptide (active) Ghrelin GIP (total) (active) GLP-1 Glucagon IL-6 Insulin ▲  ◗ ■ ** Multi-Species Hormone ■ ^ Multi-Species MSHMAG-21K) (Cat. No. Mouse Aging Panel 1 Mouse Aging Panel MAGE1MAG-25K) (Cat. No. Mouse Pituitary MPTMAG-49K) (Cat. No. Mouse Myokine MMYOMAG-74K) (Cat. No. Mouse Metabolic Hormone Expanded MMHE-44K) (Cat. No. Mouse MetabolicMouse Hormone MMHMAG-44K) (Cat.No. kits ▼ ® PAI-1 (total) PAI-1 Resistin TNFα PAI-1 (total) PAI-1 Resistin TNFα IgG2b IgG3 IgM TGFβ3

Analytes which cannot be plexed together: and total – Active and total – Free listed in Cat. No. Available Premix panel only Premix

♦ ▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (Cat. No. MGAMMAG-300K) (Cat. No.

Adiponectin Adiponectin IL-6 Leptin MCP-1/CCL2 IL-6 Insulin Leptin MCP-1/CCL2 IgE IgA IgG1 IgG2a TGFβ1 TGFβ2 TGFβ1 NON-CONFIGURABLE KIT (Serum/Plasma samples) MADPNMAG-70K-01) (Cat. No. Mouse Adiponectin – Singleplex (Cat. No. MADCYMAG-72K) (Cat. No. Mouse Adipocyte (Cell samples) culture Mouse Adipokine (Serum/Plasma samples) MADKMAG-71K) (Cat. No. Metabolism/ Endocrinology Mouse IgE – Singleplex Mouse IgE MGAMMAG-300E) (Cat. No. Immune Response Mouse Immunoglobulin Isotyping – 3 Plex TGFβ Multi-Species TGFBMAG-64K-03) (Cat. No. (Cat. No. TGFBMAG-64K-01) (Cat.No. TGFBMAG-64K-01BK) (Bulk Cat. No. Multi-Species TGFβ – TGFβ Multi-Species Singleplex FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® NEUROSCIENCE / TOXICITY / IMMUNOLOGY / METABOLISM / ENDOCRINOLOGY / CVD

MOUSE / RAT 28 |sigmaaldrich.com/milliplex Toxicity No.(Cat. RMNPMAG-83K) Mouse Neuropeptide No.(Cat. MABMAG-83K) Mouse Amyloid Beta Neuroscience (Cat. No.(Cat. MKI2MAG-94K) PanelMouse Kidney Injury 2 No.(Cat. MKI1MAG-94K) PanelMouse Kidney Injury 1 EGF Cystatin C Clusterin KIM-1 IP-10/CXCL10 β-2-Microglobulin Neurotensin β-Endorphin α-MSH Amyloid 1-40 beta Osteopontin (OPN) NGAL/Lipocalin-2 VEGF-A TIMP-1 Renin P Substance Oxytocin Amyloid 1-42 beta ■ ^ (Bulk Cat. No.(Bulk Cat. TGFBMAG-64K-01BK) No.(Cat. TGFBMAG-64K-01) Singleplex Multi-Species TGFβ – Rat Cytokine/Chemokine Immunology RAT (Cat. No.(Cat. RADPCMAG-82K) culture(Cell samples) Rat Adipocyte No.(Cat. RADPKMAG-80K) (Serum/Plasma samples) Rat Adipokine Endocrinology Metabolism/ No.(Cat. TGFBMAG-64K-03) Multi-Species TGFβ –3Plex 27 27 27 NON-CONFIGURABLE KIT IL-6 IL-5 IL-4 IL-2 IL-1β IL-1α IFNγ KC/GRO/CINC-1/ GM-CSF G-CSF Fractalkine /CX3CL1 /CCL11 Eotaxin EGF Leptin IL-6 IL-1β Adiponectin Leptin Insulin IL-6 IL-1β TGFβ2 TGFβ1 TGFβ1

CXCL1

(Bulk Cat. No.(Bulk Cat. RECYMAG65PMX27BK) No.(Cat. RECYMAG65K27PMX) (Cat. No.(Cat. RECYTMAG-65K) VEGF TNFα RANTES/CCL5 MIP-2/CXCL2 MIP-1α/CCL3 MCP-1/CCL2 LIX Leptin IP-10/CXCL10 IL-18 IL-17A/CTLA8 IL-13 IL-12 (p70) IL-10 TNFα PAI-1 (total) MCP-1/CCL2 TNFα PAI-1 (total) MCP-1 /CCL2 TGFβ3 ▼ (Cat. No.(Cat. RCI1MAG-87K) Panel Injury 1 Rat Cardiac Cardiovascular No.(Cat. RTHYMAG-30K) Rat Thyroid No.(Cat. MSHMAG-21K) (Cat. No.(Cat. RPTMAG-86K) Rat Pituitary No.(Cat. RMYOMAG-88K) Rat Myokine No.(Cat. RMHMAG-84K) Hormone Rat Metabolic Multi-Species Hormone■ ^ No.(Cat. RSHMAG-69K) Rat Stress Hormone Creatine Kinase TroponinCardiac T TroponinCardiac I T4^ T3^ Progesterone Estradiol Cortisol GH FSH BDNF ACTH IL-6 Fractalkine/CX3CL1 Follistatin-like Protein FGF-21 (EPO) Erythropoietin BDNF IL-6 Glucagon GLP-1 (active) GIP (total) Ghrelin (active) C-Peptide 2 Amylin (active) Corticosterone^ ACTH Muscle (CKM) (cTnT) (cTnI) 1 (FSTL1) ◗ ◗ ◗ ◗ TSH T4 T3 Testosterone TIMP-1 Myosin LightChain3 Follistatin-like Protein FABP3 TSH Prolactin LH Osteonectin/SPARC Osteocrin (OSTN)/ Myostatin/GDF8 LIF Irisin IL-15 TNFα PYY (total) Pancreatic MCP-1/CCL2 Leptin Insulin Melatonin^ (MYL3) 1 (FSTL1) Musclin Polypeptide (PP) ■ MILLIPLEX® CVD / BONE / NEUROSCIENCE / TOXICITY / IMMUNOLOGY FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

RAT / OTHER IL-6 IL-8/CXCL8 IL-10 (p70) IL-12 IL-13 IL-17A/CTLA8 IL-18 IP-10/CXCL10 MCP-1/CCL2 RANTES/CCL5 TNFα IL-36RA/IL-1F5 IP-10/CXCL10 MCP-1/CCL2 MIP-1α/CCL3 MIP-1β/CCL4 TNFα VEGF-A IL-15 IL-18 / CXCL10 IP-10 KC-like / CCL2 MCP-1 TNFα sigmaaldrich.com/milliplex | 29 sigmaaldrich.com/milliplex (Cat. No. BCYT1-33K) (Cat.No. (Cat. No. EQCYTMAG-93K) (Cat. No. (Cat. No. CCYTOMAG-90K) (Cat. No. (Cat. No. EQCYTMG-93KPX23) (Cat. No. EQCTMG93KPX23BK) (Cat. No. (Cat. No. BCYT1-33K-PX15) (Cat. No. BCYT1-33K-PXBK15) (Bulk Cat. No. CCYTMG-90K-PX13) (Cat. No. CCYTMAG90KPX13BK) (Bulk Cat. No.

Eotaxin/CCL11 FGF-2/FGF-basic Fractalkine/CX3CL1 G-CSF GM-CSF GRO IFNγ IL-1α IL-1β IL-2 IL-4 IL-5 IFNγ IL-1α IL-1β IL-4 IL-6 IL-8/CXCL8 IL-10 IL-17A/CTLA8 GM-CSF IFNγ IL-2 IL-6 IL-7 / CXCL8 IL-8 IL-10 15 15 13 13 23 23 Equine Cytokine/Chemokine OTHER SPECIES OTHER Immunology Cytokine/ChemokineBovine 1 Panel Canine Cytokine/Chemokine GSTα SDH Osteopontin (OPN) TIMP-1 VEGF-A C Cystatin EGF NGAL / Lipocalin-2 Requires a protease inhibitor during Requires sample collection sample extraction Requires format assay Competitive Available for custom premix Available (AGP)

5'NT/CD73 ARG1 GOT1 Clusterin GSTα^ / CXCL10 IP-10 KIM-1 Glycoprotein α-1-Acid Albumin^ β-2-Microglobulin ◗ ■ ^ (Cat. No. RLI1MAG-92K) (Cat. No. (Cat. No. RKTX1MAG-37K) (Cat.No. 2 Panel Toxicity Rat Kidney (Urine samples) RKTX2MAG-37K) (Cat. No. InjuryRat Liver Toxicity 1 Panel Toxicity Rat Kidney (Urine samples) kits ® ■ ^ Oxytocin Substance P Leptin Osteoprotegerin (OPG) PTH Sclerostin (SOST) Haptoglobin sICAM-1 IL-6 / MCP-1 CCL2 (total) PAI-1 TIMP-1 TNFα VEGF

Analytes which cannot be plexed together: and total – Active and total – Free Premix panel only Premix

▼ Legend key for MILLIPLEX key Legend † Bulk indicates Space Saver Packaging Bulk indicates Space Saver (AGP) (A2M) CXCL1 Growth Factor Growth Factor (CTGF) α-MSH β-Endorphin Neurotensin ACTH DKK1 FGF-23 Insulin α-1-Acid Glycoprotein Glycoprotein α-1-Acid α-2-Macroglobulin Adiponectin sE-Selectin KC/GRO/CINC-1/ Caveolin-1 Tissue Connective (Cat. No. RMNPMAG-83K) (Cat. No. Neuroscience Rat Neuropeptide (Serum/Plasma samples) RBN1MAG-31K) (Cat. No. Bone 1 Rat Bone Panel Rat Vascular Injury Panel 3 Injury Panel Rat Vascular (Serum/Plasma samples) RV3MAG-26K) (Cat. No. Rat Vascular Injury Panel 2 Injury Panel Rat Vascular (Serum/Plasma samples) RV2MAG-26K) (Cat. No. (Cat. No. RV1MAG-26K) (Cat.No. Rat Vascular Injury Panel 1 Injury Panel Rat Vascular samples) (Serum/Plasma FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® IMMUNOLOGY / METABOLISM / ENDOCRINOLOGY / TOXICITY

OTHER 30 |sigmaaldrich.com/milliplex Panel 1 Ovine Cytokine/Chemokine Feline Cytokine/Chemokine (Cat. No.(Cat. TGFBMAG-64K-03) Multi-Species TGFβ –3Plex No.(Bulk Cat. TGFBMAG-64K-01BK) No.(Cat. TGFBMAG-64K-01) Singleplex Multi-Species TGFβ – Porcine Cytokine/Chemokine 13 13 14 14 19 19 NON-CONFIGURABLE KIT NON-CONFIGURABLE KIT TGFβ2 TGFβ1 TGFβ1 IL-4 IL-2 IL-1Ra IL-1β IL-1α IFNγ GM-CSF IL-10 IL-8/CXCL8 IL-6 IL-4 IL-1β IL-1α IFNγ IL-12 (p40) IL-8 /CXCL8 IL-6 IL-4 IL-2 IL-1β IFNγ GM-CSF Flt3 Ligand sFAS/TNFRSF6

(Bulk Cat. No.(Bulk Cat. PCYTMAG23PMX13BK) No.(Cat. PCYTMG-23K-13PX) No.(Bulk Cat. SCYT1-91K-PXBK14) No.(Cat. SCYT1-91K-PX14) No.(Bulk Cat. FCYTMAG20KPX19BK) No.(Cat. FCYTMAG-20K-PMX) (Cat. No.(Cat. PCYTMAG-23K) No.(Cat. SCYT1-91K) Bulk indicatesSpace Saver Packaging ▼ † Legend key forMILLIPLEX

Premix panelonly –Free andtotal –Active andtotal together: whichcannotbeplexed Analytes

NEW

TGFβ3 TNFα IL-18 IL-12 IL-10 IL-8/CXCL8 IL-6 VEGF-A TNFα MIP-1β/CCL4 MIP-1α/CCL3 IP-10/CXCL10 IL-36RA/IL-1F5 IL-17A/CTLA8 TNFα SDF-1 /CXCL12 SCF RANTES /CCL5 PDGF-BB MCP-1 /CCL2 KC/GRO/CINC-1/ IL-18 IL-13 CXCL1 ® ▼ ▼ kits (Cat. No.(Cat. MSHMAG-21K) Multi-Species Hormone■ ^ No.(Cat. CANPIT-96K) Panel Expanded Pituitary Canine No.(Cat. CGTMAG-98K) GutHormone Canine Endocrinology Metabolism/ ^ ■ ◗ Progesterone Estradiol Cortisol GH FSH ACTH Glucagon GLP-1 (active) ◗ GIP (total) Ghrelin (active) Amylin ◗ (total)

Available forcustom premix Competitive assay format Requires sampleextraction sample collection Requires aproteaseinhibitorduring ◗ T4 T3 Testosterone TSH Prolactin LH PYY (total) Pancreatic Leptin Insulin Polypeptide (PP) (Cat. No.(Cat. CKT2MAG-97K) (Urine samples) Panel 2 Kidney ToxicityCanine No.(Cat. CKT1MAG-97K) (Urine samples) Expanded Panel 1 Kidney ToxicityCanine Toxicity β-2-Microglobulin Albumin KIM-1 IL-8 /CXCL8 Cystatin C Clusterin TFF-3 RBP4 Osteopontin (OPN) NGAL /Lipocalin-2 MCP-1 /CCL2