FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® ANALYTE INDEX

MILLIPLEX® 18 |sigmaaldrich.com/milliplex AXL (soluble)AXL (total) ATR ATF2 (Thr71) Arginase-1 (ARG1) APRIL ApoE4 ...... E) E(Apo Apolipoprotein (Apo CIII CIII) Apolipoprotein Apolipoprotein CII (Apo CII) B) B(Apo ...... Apolipoprotein ...... AII) (Apo AII Apolipoprotein ...... AI) (Apo AI Apolipoprotein Apelin III ANGPTL6/AGF Amylin (total) Amylin (active)...... Amylin Amphiregulin ALDH1A1 ANGPTL4 ANGPTL3 Angiotensinogen (AGT) /Kringle Angiopoietin-2 (ANG) Angiogenin 1-42 1-42) (Aβ beta ...... Amyloid 1-40 1-40) (Aβ ...... beta Amyloid Albumin Akt3 (total) Akt3 (Ser472) Akt3 (total) Akt2 Akt2 (Ser474) Akt2 Akt1 (total) Akt1 Akt1 (Ser473) Akt1 (total) Akt/PKB (Ser473) Akt/PKB ALK-1 (soluble) Agouti-Related (AgRP) D Adipsin/Factor Adiponectin ADAMTS13 9(total) Caspase Active 8(total) Caspase Active ACTH α-Synuclein α-MSH α-Fetoprotein (AFP) (A2M)...... α-2 Macroglobulin α-1 Microglobulin α-1-Antitrypsin (A1AT) (AGP) . α 1-Acid A 6Ckine/CCL21/Exodus-2 5’-NT/CD73 4E-BP1 (Thr37/46) (total) 4E-BP1 4-1BBL/TNFSF9 4–6 MILLIPLEX β-2-Microglobulin B B7-H5/VISTA B7-H4/VTCN1 B7-H3/CD276 B7-H2/ICOSL β -Tubulin...... (total) ...... () β2-Glycoprotein β-Endorphin Analyte ...... C,H,M,NHP,R ® ...... H,M,NHP,R Analyte SpeciesIndex Analyte Species C,H,M,R H,NHP H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R C,H,R H,M H,M H,M H,M H,M H,M C,H H,R H,R M M H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H

C1q (autoantibody) Collagen IV CNTF CK-MB Chk2 (Thr68) Chk1 (Ser345) (autoantibody) B) Protein (Centromere CENP-B (autoantibody) A) Protein (Centromere CENP-A CD226/DNAM-1 ...... CD137/4-1BB/TNFRSF9 (soluble) CEA CD86/B7-2 CD80/B7-1 CD44 (soluble)CD40L CD40 CD31/PECAM-1 (soluble) CD30/TNFRSF8 CD30 (soluble) CD28 CD27 CD25/IL-2Rα CD14 (soluble) CD3ε (panTyr) . B1 (autoantibody) CCNB1/Cyclin CCL28 (CAV-1) Caveolin-1 Blk (Tyr389) Blk BIM BTLA BRAK/CXCL14 (Ser446)BRAF BNP BMP-9 Cathepsin D T(cTnT) Troponin Cardiac ...... I(cTnI) Troponin Cardiac 9(CA9). Anhydrase Carbonic Calbindin CA19-9 CA15-3 Betacellulin BDNF (interaction) Bcl-xL/BAD Bcl-xL (total) CA125 (CRP). -Reactive 2 C- C-Peptide ...... (total) c-Myc (panTyr)c-Met/HGFR (soluble)c-Kit/SCFR (panTyr) c-Kit (Ser73) c-Jun C Bcl-2 (Ser70) Bcl-2 Bcl-2 (total) BCA-1/CXCL13 (total) BAX BAFF/Blys (autoantibody) BAFF/Blys BAD (Ser112) BAD (total) B7-H6 Analyte ...... Mul/Multi-Species, NHP/Non-Human Primate, O/Ovine, Por/Porcine, R/Rat ...... B/Bovine, C/Canine, E/Equine, F/Feline, G/Chicken, H/Human, M/Mouse, ...... Species ...... H,M,NHP H,M,NHP C,H,M,R H,NHP H,NHP H,M,R H,M,R H,M,R H,M,R H,M H,M H,M H,M M,R M H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H R R R

Complement C1q Cystatin C YRA21-1 CYFR CXCL16 CXCL6/GCP-2 CTLA-4/CD152 CTAG1B/NY-ESO-1 (autoantibody) CTACK/CCL27 (total)CREB (Ser133) CREB (CKM) ...... Muscle Kinase Creatine (Ser338) CRAF Corticosterone Contactin-1 (CTGF) Factor Growth Tissue Connective Extracellular Matrix Protein 1(ECM1). Protein Matrix Extracellular Estradiol (soluble)E-Selectin ...... (total) 1/2 Erk/MAPK (Thr185/Tyr187) 1/2 Erk/MAPK (panTyr)...... ErbB4/HER4 (panTyr)ErbB3/HER3 ErbB2/HER2 (panTyr) ErbB1/EGFR (panTyr) (EPO) EpCAM Complement Factor I Eotaxin-3/CCL26 Eotaxin-2/CCL24/MPIF-2 Eotaxin/CCL11 ENO1 (autoantibody) Complement Factor H Endothelin-1 Endoglin Endocan-1 (ESM-1) Endocan-1 ENA-78/CXCL5 (Ser51) eIF2a (Ser1108) eIF-4G (Ser209) eIF-4E (Ser422) eIF-4B EGFR3/Her3/ErbB3 (soluble) Complement Factor B C5a Complement Complement C5 EGFR2/Her2/ErbB2 (soluble) EGFR/HER1/ErbB1 (soluble) EGF FADD (Ser194) FADD Complement C4b Complement Complement C4 Complement C3b/iC3b Complement C3 Complement C2 E-Cadherin E DPP4 DKK1 D-dimer D FABP4 FABP1 F FABP3 Analyte ...... E,H,M,NHP,R ...... Species C,H,M,R ...... H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,Mul ... H,M H,M H,M H,M H,M H,R Mul H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H R R R

MILLIPLEX® ANALYTE INDEX FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

MILLIPLEX® C H H H H H H H H H H H H H H H H H H H H H H H H H H H M F,M H,R B,O H,M H,M H,M H,M H,M NHP F,H,M H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,NHP E,H,M,R C,H,M,R G,H,NHP H,M,NHP H,M,NHP H,M,NHP H,M,NHP H,M,NHP Species G,H,M,NHP ...... C,H,M,NHP,R C,H,M,NHP,R C,H,M,NHP,R . E,F,H,M,HNP,R B,E,H,M,NHP,O,R C,E,F,H,NHP,Por,R ...... B,C,E,H,M,NHP,O,R ...... sigmaaldrich.com/milliplex | 19 sigmaaldrich.com/milliplex ...... Analyte L Lactotransferrin (LTF) J Jag1 JNK/SAPK1 (Thr183/Tyr185) K Kallikrein-6 Protein KC-like KC/GRO/CINC-1/CXCL1 ...... 10 Keratin-1, Keratin-6 KIM-1 Ku (autoantibody)...... LAG-3 L AT (panTyr) Lck (panTyr) Lck (Tyr394) Leptin . IL-12 (p40) (p40) (autoantibody)...... IL-12 IL-12 (p70) IL-12/23 (p40) IL-13 ...... -Taxilin IL-14/α IL-15 (autoantibody) IL-15 IL-16 IL-17A /C TL A8 JNK/SAPK1 (total) (autoantibody) Jo-1 IL-17A/CTLA8 (autoantibody) IL-17A/CTLA8 IL-17A /F IL-17E/IL-25 IL-17F (autoantibody) IL-17F IL-18 IL-19 IL-24 IL-20 IL-21 IL-34 IL-22 (autoantibody) IL-22 IL-28B/IFNλ3 IL-29/IFNλ1 IL-23 IL-27 IL-28A/IFNλ2 IR (total) IR (panTyr) IL-36Ra/IL-1F5 IL-37/IL-1F7 IL-38/IL-1F10 Insulin Involucrin IP-10/CXCL10 IR (Tyr1162/1163) Irisin IRS1 (Ser636) IL-32α (mature) IL-33/NF-HEV IL-35 IL-36β/IL-1F8 IRS1 (total) I-TAC/CXCL11 IL-31 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H M M M Por G,H H,M H,M H,M H,M H,M H,M H,M H,M H,M H,M H,M H,M H,M H,M H,M,R H,M,R C,H,M Species H,NHP,Por ...... E,H,M,NHP,R ...... B,C,E,F,H,NHP,O,Por ...... B,E,H,M,NHP,O,Por,R ...... B,E,F,H,M,NHP,O,Por,R B,E,F,H,M,NHP,O,Por,R C,E,F,G,H,M,NHP,Por,R ...... B,C,E,G,H,M,NHP,O,Por,R ...... B,C,E,F,G,H,M,NHP,O,Por,R B,C,E,F,G,H,M,NHP,O,Por,R ...... (autoantibody) ...... Analyte I I-309/CCL1 ICAM-1 (soluble) ICAM-1 ICOS IL-12 HGFR/c-Met (soluble) HGFR/c-Met HIF-1α (autoantibody) HIF-1α HMGB1 HSP27 (Ser78) IFNγ (autoantibody) IFNγ IFNβ IDO1 IFNα2 (autoantibody) IFNβ HSP70 Human Serum Albumin (HSA) HVEM HSP60 (autoantibody) HSP60 IFNγ IgA IgE IGF-1 IGF-2 IGF1R (total) IGF1R (panTyr) IGF1R (Tyr1135/1136) IGFBP1 IFNβ1 IGFBP2 IGF2BP2/IMP2 (autoantibody) IGF2BP2/IMP2 IGFBP3 (autoantibody) IGF2BP3/IMP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 IgG1 IgG2 IgG2a IL-6 (autoantibody) IL-6 IL-2Rα (soluble) IL-2Rα IgG2b IgG3 IgG4 IgM ...... IκBα (Ser32) IKKα/β (Ser177/181) IL-1β (soluble) IL-1RI (soluble) IL-1RII IL-2 IL-1α (autoantibody) IL-1α IL-3 IL-4 (soluble) IL-4R IL-5 IL-6 (soluble) IL-6R (soluble) IL-6Rα IL-1Ra IL-7 IL-9 IL-8/CXCL8 IL-8/CXCL8 IL-10 (autoantibody) IL-10 IL-11

R R H H H H H H H H H H H H H H H H H H H H H H H H H H H H H F,H E,H H,R H,R H,M H,M H,M H,M H,M H,M F,H,M H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,NHP ...... H,M,NHP H,M,NHP Species ..... Analyte (continued) Index Species E,H,M,NHP ® E,H,M,NHP,R E,H,M,NHP,R C,H,M,NHP,R C,H,M,NHP,R C,H,M,NHP,R C,H,M,NHP,R C,H,M,NHP,R C,H,M,NHP,R ...... C,E,F,H,M,NHP,Por,R ...... Analyte B/Bovine, C/Canine, E/Equine, F/Feline, G/Chicken, H/Human, M/Mouse, H/Human, M/Mouse, G/Chicken, F/Feline, E/Equine, C/Canine, B/Bovine, R/Rat Por/Porcine, O/Ovine, Primate, NHP/Non-Human Mul/Multi-Species, H H2A.X (Ser139) HCC-1/CCL14 HB-EGF HCC-4/CCL16 HCGβ Hck (Tyr411) HE4 Galectin-1 G Galectin-1 (GAL1) (autoantibody) (GAL1) Galectin-1 MILLIPLEX ...... (soluble) (sFasL) Fas/TNFRSF6 (soluble) Ferritin Fetuin A...... FGF-1/FGF-acidic Hepsin (autoantibody) HER2/ErbB2 HGF Galectin-3 FGF-2/FGF-basic Galectin-3 (GAL3) (autoantibody) Galectin-3 (GAL3) GAPDH (total) G-CSF G-CSF (autoantibody) FGF-23 (panTyr) FGFR1 (Tyr420) Fyn FGF-19 FGF-21 GITRL Ghrelin...... (active) GIP (total) GITR GLP-1 (total) (Ser21) GSK3α GSK3β (total) (Ser9) GSK3β GSTα GDF-11 GDF15 GDNF GH Glial Fibrillary Acidic Protein...... (GFAP) ...... (active) GLP-1 Glucagon GnRH GOT1 (soluble) GP130 KC/GRO/CINC-1/CXCL1 ...... GSK3α (total) GM-CSF FGL1/Hepassocin Fgr (Tyr412) Flt3 (panTyr) FSH Fractalkine/CX3CL1 Fibrinogen (FAP) Protein Activation Flt3 Ligand (FST) (FSTL1) 1 Protein Follistatin-like Granulysin Granzyme A...... GROα Granzyme B...... FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® ANALYTE INDEX

MILLIPLEX® 20 |sigmaaldrich.com/milliplex ...... /GDF8 ...... 3(MYL3) Chain Light Myosin Myoglobin Myeloperoxidase (MPO) (autoantibody) (MPO) ...... Myeloperoxidase -1 (MUC1) (autoantibody) mTOR (total) (Ser2448) mTOR (Ser212) MSK1 MPIF/CCL23 MMP-13 MMP-12 MMP-10 MMP-9 MMP-8 MMP-7 MMP-3 MMP-2 MMP-1 ...... MIP-4/PARC/CCL18 MIP-3β/CCL19 MIP-3α/CCL20 MIP-2/CXCL2 MIP-1δ/MIP-5/CCL15 MIP-1β/CCL4 MIP-1α/CCL3 MIG/CXCL9 MIF Midkine MICB MICA Mesothelin Melatonin (MIA) Protein Activity Inhibitory Melanoma (Ser222)MEK1 MDM2 (total) Mi-2 (autoantibody) MDH1 MDC/CCL22 (panTyr)M-CSFR ...... M-CSF MCP-5/CCL12 MCP-4/CCL13 MCP-3/CCL7 MCP-2/CCL8 MCP-1/CCL2 Nectin-2 NCAML1/L1CAM/CD171 Mcl-1 (total) Mcl-1/BIM (interaction) MCAM/MUC18/sCD146 (MBL) Lectin Mannose-Binding M (Tyr397) Lyn Lymphotactin/XCL1 L-Selectin (soluble) LIX/CXCL6/GCP-2 LIGHT LH (LIF) Factor Inhibitory Leukemia (LRG1) alpha-2-glycoprotein 1 Leucine-rich MILLIPLEX NCAM (soluble)NCAM NAP-2/CXCL7 N Analyte ...... B,C,E,F,H,M,NHP,R ...... B,G,H,M,NHP,O B,H,M,NHP,O,R C,H,M,NHP,R ® ...... G,H,M,NHP ...... Analyte SpeciesIndex(continued) Analyte Species .... G,H,M H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M H,M H,M H,M H,M H,M H,M H,M H,M M,R H,R H,R . M H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H R

Neurotensin ...... proBNP NT (interaction) NOXA/Mcl-1 NGAL/Lipocalin-2 (Ser536) NFκB NFκB (total) . (ELA2) Elastase-2 PSA (free) Proteinase 3 (autoantibody) ProMMP-9 Prolactin Progesterone (PrionPRNP Protein) PM/Sci 100 (autoantibody) ...... 4(PF4)/CXCL4 Factor ...... (PLGF) Factor Growth Placental 2 ...... Factor Growth Placental (autoantibody) PL-12 Synthetase) (Alanyl-tRNA (pGRN) Progranulin ...... Periostin Perforin Pentraxin-3 (PTX3) ...... PEDF PD-L2 ...... PD-L1 (panTyr) ...... PDGFRβ (panTyr)PDGFRα ...... PDGF-BB PDGF-AB/BB PDGF-AA PD-1 A)Antigen (autoantibody) Nuclear Cell (Proliferating PCNA ...... 7) Protein Disease PARK7/DJ1 (Parkinson’s PARK5/UCHL1 ...... (PP) Polypeptide Pancreatic PAI-1 ...... (total) p70S6 (Thr389/412) Kinase ...... (total) p70S6 Kinase ...... (Ser46) p53 (Ser15) p53 Neuropilin-1 (soluble) Enolase Neuron-specific (NSE) (NRGN) Neurogranin Nectin-4 Notch1 ...... NGF Oxytocin OX40/CD134 (OPG)Osteoprotegerin (OPN) ...... /SPARC (OSTN)/Musclin Osteocrin (OC) ...... Osteocalcin Osteoactivin (OSM) ...... Oncostatin-M O p53 (autoantibody) (total)p38/SAPK2A/B (Thr180/Tyr182) p38/SAPK2A/B (total) p21 P16-INK4a (autoantibody) P Analyte ...... Mul/Multi-Species, NHP/Non-Human Primate, O/Ovine, Por/Porcine, R/Rat ...... B/Bovine, C/Canine, E/Equine, F/Feline, G/Chicken, H/Human, M/Mouse, ...... C,H,M,NHP,R ...... Species C,H,M,R C,H,M,R C,H,M,R H,NHP H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M H,M M,R Mul M M M H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H F

(sSOD1) 1(soluble) Dismutase Superoxide P ...... Substance STAT6 (Tyr641) ...... (Tyr694/699) ...... STAT5A/B STAT5A/B (total) (Tyr705) TAT3 S (Ser727) TAT3 S (total) STAT3 STAT2 (Tyr690)...... (Tyr701) TAT1 S B/La)antigen (autoantibody) Syndrome-related (Sjögren’s SB/La kDa) A/Ro60 antigen (autoantibody) SSA/Ro60 (Sjögren’s Syndrome-related antigen A/Ro52 kDa)antigen (autoantibody) SSA/Ro52 (Sjögren’s Syndrome-related (Tyr419) Src SOX2 (autoantibody) SMAD4 (total) SMAD4 (Ser423/425) SMAD3 SMAD2 (Ser465/467) Sm (autoantibody) Siglec-9 Siglec-7 ...... (SHBG) Globulin Binding Hormone Sex P(SAP) Amyloid Serum ...... A(SAA) Amyloid Serum Secretin SDH SCF ...... S2 Spike SARS-CoV-2 S1...... Spike SARS-CoV-2 SDF-1/CXCL12 ...... (SOST) Sclerostin Scl-70 (autoantibody) SARS-CoV-2 RBD SARS-CoV-2 PTH (Ser380) ...... PTEN (total)PTEN (soluble)P-Selectin . (total) PSA RPS6 (total)RPS6 (Ser235/Ser236) RPS6 RNP/Smith (RNP/Sm) (autoantibody) (autoantibody) RNP (Ribonucleoprotein) P (autoantibody)Ribosomal ...... Resistin Renin ...... RBP4 (total) RasG12V . (total) RasG12D (total) Ras RANTES/CCL5 ...... RANKL (soluble)RAGE R SARS-CoV-2 N SARS-CoV-2 S100B S . (total) PYY PVR/CD155 Analyte ...... E,F,G,H,M,HNP,R ...... C,H,M,NHP,R ...... Species H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R H,M,R F,H,M ...... H,M H,M H,M H,M H,M H,M H,M C,H H,R H,R F,H H H H H H H H H H H H H H H H H H H H H H H H H H H H

MILLIPLEX® ANALYTE INDEX FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES.

MILLIPLEX® H H H H H H H H H G,R H,M H,M H,M H,M H,M H,M,R H,M,R Species ...... B,H,M,NHP,O,R ...... sigmaaldrich.com/milliplex | 21 sigmaaldrich.com/milliplex ...... Analyte VEGF-A VEGF-C U ucMGP . (soluble)/CD87 uPAR V (soluble) VCAM-1 VEGF Y ...... (Tyr421) Yes YKL40/CHI3L1 Z ...... (panTyr) ZAP-70 Uromodulin VEGF-D VEGFR1/Flt-1 (panTyr) VEGFR1/Flt-1 (soluble) VEGFR1/Flt-1 (panTyr) VEGFR2/KDR/Flk-1 (soluble) VEGFR2/KDR/Flk-1 (panTyr) VEGFR3/Flt-4 (soluble) VEGFR3/Flt-4 Vitamin D Binding Protein ...... H H H H H H H H H H H H H H H H,M H,M H,M H,M H,M,R H,M,R H,M,R H,M,NHP Species C,H,M,NHP,R ...... B,C,E,F,H,M,NHP,O,Por,R ......

...... (autoantibody) ...... ? ® Analyte TIM-3 TIMP-1 TIMP-2 TIMP-3 TIMP-4 ...... Tissue Factor (TF) ...... TLR-2 TNFR1 (total) TNFα TNFα TNFβ/-α (LTA) ...... TNF RI (sTNFR1) (soluble) TNF. RII (sTNFR2) (soluble) TPO TRAIL/TNFSF10 (TGM2) 2 Transglutaminase TRAP5 ...... TREM2 Troponin I (TnI) Troponin T (TnT) TSC2 (total) TSC2 ...... (Ser939) TSH ...... TSLP ...... TWEAK ...... H H H H H H H H H H H H Mul Mul Mul Mul C,H H,M H,M Mul,R Mul,R H,NHP Species Analyte (continued) Index Species ...... ® ...... What’s in the MILLIPLEX What’s ...... Analyte B/Bovine, C/Canine, E/Equine, F/Feline, G/Chicken, H/Human, M/Mouse, H/Human, M/Mouse, G/Chicken, F/Feline, E/Equine, C/Canine, B/Bovine, R/Rat Por/Porcine, O/Ovine, Primate, NHP/Non-Human Mul/Multi-Species, 27; Primate p. 27-29; NHP/Non-Human 22-26; M/Mouse pp. H/Human pp. 32-35 31; kitspp. 29-30; All other species p. R/Rat pp...... Syk (panTyr) T3 T4 T Superoxide Dismutase 2 (soluble) (sSOD2) MILLIPLEX Survivin/BIRC5 (autoantibody) Survivin/BIRC5 TARC/CCL17 (Total) Tau ...... (Thr181) Tau (TN-C) Tenascin-C Testosterone TFF-3 TGFα ...... TGFβ2 TGFβ3 ...... (total) TGFβRII Thrombomodulin (TSP-1) Thrombospondin-1 (TSP-2) Thrombospondin-2 TIE1 (panTyr) TIE2 (panTyr) (soluble) Tie-2 TGFβ1 FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® IMMUNOLOGY

HUMAN 22 |sigmaaldrich.com/milliplex Growth FactorGrowth Panel A Human // Immunology HUMAN 48 48 38 38 IL-12 (p70) IL-12 (p40) IL-10 IL-9 IL-8/CXCL8 IL-7 IL-6 IL-5 IL-4 IL-3 IL-2 IL-1RA IL-1β IL-1α IFNγ IFNα2 GROα GM-CSF G-CSF Fractalkine/CX3CL1 Flt3 Ligand FGF-2/FGF-basic Eotaxin/CCL11 EGF sCD40L

(Cat. No. (Cat. HCYTA-60K-PXBK48) No. (Cat. HCYTA-60K-PX48) No. (Cat. HCYTA-60K-PXBK38) No. (Cat. HCYTA-60K-PX38) (Cat. No.(Cat. HCYTA-60K) information, see ourApplicationNote . that previouslyindividual immunefactors have notbeentogetherinasinglepanel. For more The MILLIPLEX andCustomizable! 48-Plex:Larger Human Cytokine ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ TNFβ/Lymphotoxin-α TNFα TGFα RANTES/CCL5 PDGF-AB/BB PDGF-AA MIP-1β/CCL4 MIP-1α/CCL3 MIG/CXCL9 MDC/CCL22 M-CSF MCP-3/CCL7 MCP-1/CCL2 IP-10/CXCL10 IL-27 IL-22 IL-18 IL-17F VEGF-A IL-17E/IL-25 IL-17A/CTLA8 IL-15 IL-13 ® (LTA) Human Cytokine/Chemokine/ HumanCytokine/Chemokine/Growth Panel for48 Acombinestests ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦

♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦▲ Panel I Human Cytokine/Chemokine (Cat. No.(Cat. HCYP3MAG-63K) Panel III Human Cytokine/Chemokine Panel II Human Cytokine/Chemokine 41 41 38 38 30 30 29 29 23 23 IL-8 /CXCL8 ♦ IL-7 IL-6 IL-5 IL-4 IL-3 IL-2 IL-1Ra IL-1β IL-1α IFNγ IFNα2 GRO GM-CSF G-CSF Fractalkine /CX3CL1 Flt3 Ligand FGF-2 /FGF-basic /CCL11♦ Eotaxin EGF sCD40L Lymphotactin /XCL1 LIX /CXCL6 /GCP-2 I-TAC /CXCL11 IL-29 /IFNλ1 IL-11 HCC-1 /CCL14▲ IL-23 IL-21 IL-20 IL-16 I-309/CCL1 Eotaxin-3/CCL26 Eotaxin-2/CCL24/ ENA-78/CXCL5 CTACK/CCL27 BCA-1/CXCL13 6Ckine/CCL21/

MPIF-2 Exodus-2 (Bulk Cat. No. (BulkCat. HCYTMAG60PMX41BK) No. (Cat. HCYTMAG-60K-PX41) No. (BulkCat. HCYTMAG60PMX38BK) No. (Cat. HCYTMAG-60K-PX38) No.(Bulk Cat. HCYTMAG60PMX30BK) No. (Cat. HCYTMAG-60K-PX30)

(Bulk Cat. No.(Bulk Cat. HCYTMAG60PMX29BK) No.(Cat. HCYTMAG-60K-PX29) (Bulk Cat. No.(Bulk Cat. HCP2MAG62KPX23BK) No.(Cat. HCP2MAG-62K-PX23) (Cat. No.(Cat. HCYP2MAG-62K) (Cat. No.(Cat. HCYTOMAG-60K) ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ VEGF-A TNFβ /Lymphotoxin-α TNFα TGFα RANTES /CCL5♦ PDGF-AB /BB PDGF-AA MIP-1β /CCL4♦ MIP-1α /CCL3♦ MDC /CCL22 MCP-3 /CCL7 MCP-1 /CCL2♦ IP-10 /CXCL10 ♦ IL-17A ♦ /CTLA8 IL-15 IL-13 IL-12 (p70) IL-12 (p40) IL-10 IL-9 NAP-2 /CXCL7 ▲ MIP-3β /CCL19 MIP-3α /CCL20 MIG /CXCL9 M-CSF TSLP TRAIL/TNFSF10 TPO TARC/CCL17 SDF-1/CXCL12 SCF MIP-1δ/MIP-5/CCL15 MCP-4/CCL13 MCP-2/CCL8 LIF IL-33/NF-HEV IL-28A/IFNλ2 (LTA) (mature) ♦ ♦ ♦ ♦ ♦ ♦ ▲ ♦ ♦ ♦ ▲ ▲ ♦ T Cell Human HighSensitivity No.(Cat. HIL18MAG-66K) Human IL-18 Singleplex Panel IV Human Cytokine/Chemokine (Cat. No.(Cat. HSTC384-28K) TCell Sensitivity 384-well HumanHigh 21 21 20 20 21 21 13 13 IL-18 IL-24 IL-19 IL-14 /α-Taxilin IFNβ HMGB1 ● HCC-4 /CCL16 CXCL16 CCL28 BRAK /CXCL14 BAFF /Blys IL-10 IL-8 /CXCL8 IL-7 IL-6 IL-5 IL-4 IL-2 IL-1β IFNγ GM-CSF Fractalkine /CX3CL1 IL-10 IL-8 /CXCL8 ♦ IL-7 IL-6 IL-5 IL-4 IL-2 IL-1β IFNγ GM-CSF Fractalkine /CX3CL1

(Cat. No. (Cat. HSTCMAG28SPMX21) No. (BulkCat. HSTCMAG28PMX21BK) (Bulk Cat. No.(Bulk Cat. HSTCMAG28PMX13BK) No.(Cat. HSTCMAG28SPMX13) No.(Bulk Cat. HCP4MG64KPX20BK) No.(Cat. HCY4MG-64K-PX20) (Bulk Cat. No.(Bulk Cat. HSTCMAG384PX21BK) No.(Cat HSTCMAG384-PX21) (Cat. No.(Cat. HSTCMAG-28SK) No.(Cat. HCYP4MAG-64K) ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ ♦ YKL40/CHI3L1 MPIF /CCL23 MIP-4 /PARC /CCL18 IL-38 /IL-1F10 IL-37 /IL-1F7 IL-36β /IL-1F8 IL-35 IL-34 IL-32α IL-28B /IFNλ3 TNFα MIP-3α /CCL20 MIP-1β /CCL4 MIP-1α /CCL3 I-TAC /CXCL11 IL-23 IL-21 IL-17A /CTLA8 IL-13 IL-12 (p70) TNFα MIP-3α /CCL20 MIP-1β /CCL4 MIP-1α /CCL3 I-TAC /CXCL11 IL-23 IL-21 IL-17A /CTLA8 IL-13 IL-12 (p70) ♦ ♦ ♦ ♦ ♦ MILLIPLEX Human Th17 Human Complement Panel 2 Immune Response (Cat. No. HTH17MAG-14K) (Cat. No. HCMP2MAG-19K) Human Autoimmune 25 (Cat. No. HT17MG-14K-PX25) C1q C4 25 (Bulk Cat. No. HT17MAG14PMX25BK) Autoantibody** ® C3 Factor B IMMUNOLOGY / IMMUNE RESPONSE (Cat. No. HAIAB-10K) GM-CSF IL-17E / IL-25 C3b Factor H IFNγ IL-17F β2-Glycoprotein Ribosomal P IL-1β IL-21 C1q RNP Human MMP Panel 1 IL-2 IL-22 CENP-A (Centromere (Ribonucleoprotein) IL-4 IL-23 (Cat. No. HMMP1MAG-55K) Protein A) RNP/Smith (RNP/ IL-5 IL-27 CENP-B (Centromere Sm) MMP-3 MMP-13 IL-6 IL-28A / IFNλ2 Protein B) Scl-70 MMP-12 IL-9 IL-31 Jo-1 Sm IL-10 IL-33 / NF-HEV Ku SSA/Ro52 (Sjögren’s Syndrome-related IL-12 (p70) (mature) Human MMP Panel 2 Mi-2 antigen A/Ro52 MIP-3α / CCL20 Myeloperoxidase IL-13 (Cat. No. HMMP2MAG-55K) kDa) HUMAN TNFα (MPO) IL-15 SSA/Ro60 TNFβ/Lymphotoxin-α MMP-1 MMP-9 PCNA (Proliferating IL-17A / CTLA8 Cell Nuclear (Sjögren’s (LTA) MMP-2 MMP-10 Antigen A) Syndrome-related MMP-7 antigen A/Ro60 PL-12 (Alanyl-tRNA kDa) Human CD8+ T Cell Synthetase) SB/La (Sjögren’s PM/Sci 100 (Cat. No. HCD8MAG-15K) Human TIMP Panel 1 Syndrome-related Proteinase 3 17 (Cat. No. HCD8MAG15K17PMX) (Serum/Plasma samples) antigen B/La) 17 (Bulk Cat. No. HCD8MAG15KPX17BK) (Cat. No. HTMP1MAG-54K) Human Cytokine sCD137/4-1BB/ IL-4 TIMP-1 TIMP-2 Autoantibody ** TNFRSF9 IL-5 sFAS / TNFRSF6 IL-6 (Cat. No. HCYTAAB-17K) sFasL IL-10 Human TIMP Panel 2 BAFF/Blys IL-12 (p40) GM-CSF IL-13 (Cell culture samples) G-CSF IL-15 Granzyme A MIP-1α / CCL3 (Cat. No. HTMP2MAG-54K) IFNβ IL-17A/CTLA8 Granzyme B MIP-1β / CCL4 TIMP-1 TIMP-3 IFNγ IL-17F IFNγ Perforin TIMP-2 TIMP-4 IL-1α IL-18 IL-2 TNFα IL-6 IL-22 IL-8/CXCL8 TNFα Human Soluble Cytokine Multi-Species TGFβ – IL-10 Receptor Singleplex # (Cat. No. HSCRMAG-32K) (Cat. No. TGFBMAG-64K-01) Human Sepsis Panel 1 (Bulk Cat. No. TGFBMAG-64K-01BK) 14 (Cat. No. HSCRMAG32KPX14) (Cat. No. HSP1MAG-63K) 14 (Bulk Cat. No. HSCRMAG32PMX14BK) TGFβ1 sFAS / TNFRSF6 MIF sFasL PAI-1 (total) sCD30 sIL-6R ▼ sEGFR/sHER1/ErbB1 sRAGE Multi-Species TGFβ – 3 Plex sICAM-1 sVCAM-1 sGP130 sTNF RI (Cat. No. TGFBMAG-64K-03) #

sIL-1RI sTNF RII NON-CONFIGURABLE KIT Human Sepsis Panel 2 FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. sIL-1RII sVEGFR1 / sFlt-1 (Cat. No. HSP2MAG-63K) TGFβ1 TGFβ3 sIL-2Rα sVEGFR2 / sKDR / sFlk-1 TGFβ2 sIL-4R sVEGFR3 / sFlt-4 Granzyme B MIP-1α / CCL3 HSP70 MIP-1β / CCL4 IL-1α MMP-8 Human Complement Panel 1 IL-8 / CXCL8 (Cat. No. HCMP1MAG-19K)

Adipsin/Factor D C5a Human Sepsis Panel 3 C2 Factor I (Cat. No. HSP3MAG-63K) C4b Mannose-binding Lactotransferrin (LTF) Resistin C5 Lectin (MBL) Neutrophil Elastase-2 Thrombospondin-1 (ELA2) (TSP-1) NGAL/Lipocalin-2

Legend key for MILLIPLEX® kits

† Analytes which cannot be plexed together: ◗ Requires a protease inhibitor during sample Available for custom premix – Active and total collection ◦ Analyte requires a different sample dilution – Free and total ■ Requires sample extraction from others in panel ♦ Available in Cat. No. listed ** No standard/QC; autoantibody levels are  Analyte cannot be measured in serum ▼ Premix panel only reported as MFIs # Requires sample acidification Bulk indicates Space Saver Packaging ● Serum/Plasma only S Analyte cannot be measured in plasma ▲ These analytes cannot be plexed with other ★ Tissue Culture samples only U Urine only analytes in this panel in serum/plasma ^ Competitive assay format

sigmaaldrich.com/milliplex | 23 FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® IMMUNE RESPONSE / VIROLOGY / METABOLISM / ENDOCRINOLOGY / CVD

HUMAN 24 |sigmaaldrich.com/milliplex Isotyping Isotyping Human Immunoglobulin No.(Cat. SKINMAG-50K) only) (Skin extracts Human Skin (Cat. No.(Cat. HADK2MAG-61K) (Serum/Plasma samples) Human AdipokinePanel 2 No.(Cat. HADK1MAG-61K) (Serum/Plasma samples) Human AdipokinePanel 1 Endocrinology Metabolism/ No.(Cat. HC19SERM1-85K) IgM SARS-CoV-2 AntigenPanel 1 No.(Cat. HC19SERG1-85K) IgG SARS-CoV-2 AntigenPanel 1 No.(Cat. HC19SERA1-85K) IgA SARS-CoV-2 AntigenPanel 1 Virology No.(Cat. HGAMMAG-303E) Human IgE –Singleplex Insulin IL-8/CXCL8 IL-6 IL-1β NGAL/Lipocalin-2 Adipsin/Factor D Adiponectin SARS-CoV-2 RBD SARS-CoV-2 N SARS-CoV-2 RBD SARS-CoV-2 N SARS-CoV-2 RBD SARS-CoV-2 N IgE IgG2 IgG1 IgA Human Serum ^ Cortisol

Albumin (HSA) (Cat. No.(Cat. HGAMMAG-301K)

NEW NEW NEW

** ** ** TNFα NGF MCP-1/CCL2 Leptin Resistin PAI-1 (total) SARS-CoV-2 Spike S2 SARS-CoV-2 Spike S1 SARS-CoV-2 Spike S2 SARS-CoV-2 Spike S1 SARS-CoV-2 Spike S2 SARS-CoV-2 Spike S1 IgM IgG4 IgG3 Keratin-6 Keratin-1,10 Involucrin (Cat. No.(Cat. HMH3-34K) V3 Hormone Human Metabolic (Cat. No.(Cat. HAGE1MAG-20K) Human AgingPanel 1 No.(Cat. HMYOMAG-56K) Human No.(Cat. HMHEMAG-34K) Hormone Human Metabolic Human Diabetes No.(Cat. HADCYMAG-61K) culture(Cell samples) Human Adipocyte 5 5 GnRH GDF15 GDF-11 FGF-21 CTACK/CCL27 NON-CONFIGURABLE KIT IL-6 Glucagon ◗ GLP-1 † (total) GLP-1 (active) † GIP (total) Ghrelin (active) C-Peptide Amylin † (total) Amylin (active) † Glucagon GLP-1 (active) C-Peptide IL-6 FSTL1 Fractalkine/CX3CL1 FGF-21 FABP3 (EPO) Erythropoietin BDNF Apelin Glucagon †◗ (total) GLP-1 (active) †◗ GLP-1 GIP (total) Ghrelin (active) C-Peptide †◗ (total) Amylin (active) †◗ Amylin Leptin IL-8/CXCL8 IL-6 IL-1β HGF Adiponectin HDIAB-34K-PMX5) (Cat.No. (Bulk Cat. No.(Bulk Cat. HDIAB34KPMX5BK)

NEW ◗ ◗ ◗ ◗ ◗ ◗ ◗ ◗ ◗ IL-10 IL-6 Leptin Jag1 IL-18 TNFα Secretin PYY (total) Pancreatic MCP-1/CCL2 Leptin Insulin Leptin Insulin Osteonectin/SPARC Osteocrin (OSTN)/ (OSM) Oncostatin-M Myostatin/GDF8 LIF Irisin IL-15 TNFα PYY (total) Pancreatic MCP-1/CCL2 Leptin Insulin IL-6 TNFα Resistin PAI-1 (total) NGF MCP-1/CCL2 ▼ Polypeptide (PP) Musclin Polypeptide (PP) ★ (Cat. No.(Cat. HPTP1MAG-66K) Panel 1 Human Pituitary No.(Cat. HIGFMAG-52K) Human IGF No.(Cat. HIGFBMAG-53K) Human IGFBindingProtein No.(Cat. HLPPMAG-57K) Human Liver Protein (Cat. No.(Cat. HCVD3MAG-67K) (Acute Phase) PanelHuman CVD 3 No.(Cat. HCVD2MAG-67K) PanelHuman CVD 2 No.(Cat. HCVD1MAG-67K) PanelHuman CVD 1 Cardiovascular No.(Cat. MSHMAG-21K) Multi-Species Hormone CNTF Agouti-Related ACTH IGF-1 IGFBP4 IGFBP3◦ IGFBP2 IGFBP1 FABP1 ANGPTL6 ANGPTL4 ANGPTL3 α-Fetoprotein (AFP) Fibrinogen  Fetuin A CRP Adipsin/Factor D α-2-Macroglobulin α-1-Acid Glycoprotein Myeloperoxidase sICAM-1 GDF15 D-dimer ADAMTS13 FABP4 FABP3 Endocan-1 (ESM-1) CXCL16 CXCL6/GCP-2 CK-MB BNP Progesterone Estradiol Cortisol Protein (AgRP) (AGP) (MPO) S ■ TSH LH GH FSH IGF-2 IGFBP7 IGFBP6 IGFBP5 HGF FGF-23 FGF-21 FGF-19 Serum Amyloid P sL-Selectin Haptoglobin Troponin I(TnI) Growth Placental (OSM) Oncostatin-M NT proBNP LIGHT T4 T3 Testosterone sVCAM-1 Serum Amyloid A sP-Selectin NGAL/Lipocalin-2 Myoglobin (SAP) (PF4)/CXCL4 Factor (PLGF) ■

^ ◗ MILLIPLEX Human CVD Panel 4 Human Immuno-Oncology Human Circulating Cancer (Cat. No. HCVD4MAG-67K) Checkpoint Protein Panel 2 Biomarker Panel 3 (Cat. No. HCKP2-11K) (Cat. No. HCCBP3MAG-58K) sCD31/sPECAM-1 Thrombomodulin ® sE-Selectin Tissue Factor (TF) 4-1BBL/TNFSF9 FGL1/Hepassocin Cathepsin D Melanoma Inhibitory / BONE CANCER CVD Follistatin (FST) Troponin T (TnT) 5’-NT/CD73 Galectin-1 Ferritin Activity (MIA) Pentraxin-3 (PTX3) APRIL Galectin-3 Fibroblast Activation Myeloperoxidase (MPO) Arginase-1 Granulysin Protein (FAP) Galectin-3 Sex Hormone Binding Human CVD Panel 6 B7-H2/ICOSL Granzyme B Globulin (SHBG) B7-H3/CD276 IDO1 IGFBP3 ◦ (Cat. No. HCVD6MAG-67K) B7-H4/VTCN1 MICA sCD14 MCAM/MUC18 B7-H5/VISTA MICB Human Circulating Cancer DPP4 Progranulin (pGRN) B7-H6 Nectin-2 Biomarker Panel 4 BAFF/BLyS Nectin-4 Endostatin ucMGP (Cat. No. HCCB4MAG-58K) LRG1 CD25/IL-2Rα OX40/CD134

CD30/TNFRSF8 Perforin ALDH1A1 Kallikrein-6 HUMAN Human Apolipoprotein CD40L PVR/CD155 Carbonic Anhydrase Mesothelin CD137/4-1BB Siglec-7 9 (CA9) Midkine (Cat. No. APOMAG-62K) CD226/DNAM-1 Siglec-9 CD44 NCAML1/L1CAM/ EpCAM CD171 Apo AI Apo CII E-Cadherin Hepsin Transglutaminase 2 Apo AII Apo CIII (TGM2) Apo B Apo E Human Cancer Autoantibody** (Cat. No. HCABMAG-13K) Human Cancer/Metastasis Biomarker Panel 1 Bone CCNB1/Cyclin B1 IGF2BP2/IMP2 (Cat. No. HCMBMAG-22K) CTAG1B/NY-ESO-1 IGF2BP3/IMP3 Human Bone ENO1 Mucin-1 (MUC1) DKK1 Osteoprotegerin (Cat. No. HBNMAG-51K) Galectin-1 (GAL1) P16-INK4a GDF15 (OPG) Galectin-3 (GAL3) p53 Neuron-specific Periostin ACTH Osteocalcin (OC) HER2/ErbB2 SOX2 Enolase (NSE) TRAP5 DKK1 Osteopontin (OPN) HIF-1α Survivin/BIRC5 Osteonectin/SPARC TWEAK FGF-23 Osteoprotegerin (OPG) HSP60 YKL40/CHI3L1 IL-1β PTH IL-6 Sclerostin (SOST) Human Angiogenesis/Growth Insulin TNFα Human Circulating Cancer Leptin Biomarker Panel 1 Factor Panel 1 (Cat. No. HCCBP1MAG-58K) (Cat. No. HAGP1MAG-12K) Human RANKL – Singleplex α-Fetoprotein (AFP) IL-8/CXCL8 Angiopoietin-2 HB-EGF (Cat. No. HRNKLMAG-51K-01) CA125 Leptin BMP-9 HGF EGF IL-8/CXCL8 RANKL CA15-3 MIF CA19-9 Osteopontin (OPN) Endoglin Leptin CEA Prolactin Endothelin-1 Placental Growth CYFRA21-1 PSA (free)† FGF-1/FGF-acidic Factor (PLGF) Cancer sFAS/TNFRSF6 PSA (total)† FGF-2/FGF-basic VEGF-A

sFasL SCF Follistatin (FST) VEGF-C FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. Human Immuno-Oncology FGF-2/FGF-basic TGFα G-CSF VEGF-D Checkpoint Protein Panel 1 HCGβ TNFα (Cat. No. HCKP1-11K) HE4 TRAIL/TNFSF10 Human Angiogenesis Panel 2 17 (Cat. No. HCKP1-11K-PX17) HGF VEGF-A (Cat. No. HANG2MAG-12K) 17 (Bulk Cat. No. HCKP1-11K-PXBK17) IL-6 Angiostatin/Kringle sIL-6Rα BTLA HVEM sAXL sNeuropilin-1 (sNRP-1) CD27 ICOS Human Circulating Cancer sCD31/sPECAM-1 Osteopontin (OPN) CD28 LAG-3 Biomarker Panel 2 sc-Kit/sStem Cell PDGF-AB/BB CD40 PD-1 (Cat. No. HCCBP2MAG-58K) Factor Receptor Tenascin-C (TN-C) CD80/B7-1 PD-L1 (SCFR) Thrombospondin-2 CD86/B7-2 PD-L2 Antithrombin III Extracellular Matrix sE-Selectin Protein 1 (ECM1) (TSP-2) CTLA-4/CD152 TIM-3 Complement Factor sEGFR/sHER1/sErbB1 H (CFH) Vitamin D Binding sTIE-2 GITR TLR-2 Protein sHER2/sEGFR2/ suPAR sErbB2 GITRL sVEGFR1/sFlt-1 sHER3/sEGFR3/ sErbB3 sVEGFR2/sKDR/sFlk-1 sHGFR/sc-Met sVEGFR3/sFlt-4

Legend key for MILLIPLEX® kits

† Analytes which cannot be plexed together: ◗ Requires a protease inhibitor during sample Available for custom premix – Active and total collection ◦ Analyte requires a different sample dilution – Free and total ■ Requires sample extraction from others in panel ♦ Available in Cat. No. listed ** No standard/QC; autoantibody levels are  Analyte cannot be measured in serum ▼ Premix panel only reported as MFIs # Requires sample acidification Bulk indicates Space Saver Packaging ● Serum/Plasma only S Analyte cannot be measured in plasma ▲ These analytes cannot be plexed with other ★ Tissue Culture samples only U Urine only analytes in this panel in serum/plasma ^ Competitive assay format

sigmaaldrich.com/milliplex | 25 FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES. MILLIPLEX® NEUROSCIENCE / TOXICITY

HUMAN 26 |sigmaaldrich.com/milliplex (Cat. No.(Cat. HNS1MAG-95K) samples) (CSF Human NeurosciencePanel 1 No.(Cat. HNABTMAG-68K) samples) (CSF Human Amyloid andTau Beta Neuroscience (Cat. No.(Cat. HNDG3MAG-36K) Disease Panel 3 Human Neurodegenerative No.(Cat. HNDG2MAG-36K) Disease Panel 2 Human Neurodegenerative No.(Cat. HNDG1MAG-36K) Disease Panel 1 Human Neurodegenerative No.(Cat. HNS2MAG-95K) Human NeurosciencePanel 2 sNCAM Myeloperoxidase sICAM-1 D Cathepsin BDNF CRP C4 α-1-Antitrypsin (A1AT) Apo E Apo CIII Apo AI α-2-Macroglobulin Ferritin FABP3 ApoE4 Angiogenin (ANG) Neuron-specific Acidic Glial Fibrillary α-Synuclein Amyloid 1-42 beta Amyloid 1-40 beta (MPO) Enolase (NSE) Protein (GFAP) Visit ourMILLIPLEX Need SomeAdvice on Running Assays? your methods. ◦ ◦ sVCAM-1 RANTES/CCL5 PDGF-AB/BB PDGF-AA PAI-1 (total) Serum Amyloid P PEDF MIP-4/PARC/CCL18 Complement Factor Complement Factor TREM2 PRNP (PrionProtein) Neurogranin (NRGN) Transglutaminase 2 PARK7/DJ1 PARK5/UCHL1 Tau (total) pTau (Thr181) (SAP) H (CFH) C3 (TGM2) ® FAQs pageanddownloadourTips Tricks brochure toperfect

(Cat. No.(Cat. HNCSMAG-35K) Human CircadianStress No.(Cat. HNPMAG-35K) Human Neuropeptide No.(Cat. HND3MAG-39K) PanelDisorders 3 Human Neurological No.(Cat. HNDG4MAG-36K) samples) (CSF Disease Panel 4 Human Neurodegenerative (Cat. No.(Cat. HKI2MAG-99K) (Urine samples) PanelHuman Kidney Injury 2 No.(Cat. HKI1MAG-99K) (Urine samples) PanelHuman Kidney Injury 1 Toxicity Neurotensin β-Endorphin α-MSH Kallikrein-6 Fetuin A◦ Contactin-1 Angiotensinogen GDNF Amyloid 1-42 beta Amyloid 1-40 beta Cystatin C Clusterin Albumin α-1-Microglobulin IP-10/CXCL10 GSTα FABP1 Collagen IV Calbindin Cortisol (AGT) Substance P Substance Oxytocin Soluble Superoxide Soluble Superoxide Osteopontin (OPN) S100B sRAGE Osteopontin (OPN) NGAL/Lipocalin-2 EGF TIMP-1 TFF-3 Renin Osteoactivin KIM-1 Melatonin Dismutase 2(sSOD2) Dismutase 1(sSOD1) Dismutase ■

^ ■

^ (Cat. No.(Cat. HKI6MAG-99K) (Serum/Plasma samples) PanelHuman Kidney Injury 6 No.(Cat. HKI5MAG-99K) (Serum/Plasma samples) PanelHuman Kidney Injury 5 No.(Cat. HKI4MAG-99K) (Serum/Plasma samples) PanelHuman Kidney Injury 4 No.(Cat. HKI3MAG-99K) (Urine samples) PanelHuman Kidney Injury 3 (Cat. No.(Cat. HLINJMAG-75K) Human Liver Injury Clusterin β-2-Microglobulin NGAL/Lipocalin-2 Collagen IV α-1-Microglobulin KIM-1 IP-10/CXCL10 FABP1 EGF RBP4 β-2-Microglobulin GSTα ARG1 5'NT/CD73 RBP4 Cystatin C Uromodulin TIMP-1 Osteoactivin Renin PTH Osteopontin (OPN) Uromodulin SDH MDH1 Design your own assay with our custom development services

ProcartaPlex assays provide the ultimate in flexibility; you The ProcartaPlex multiplex immunoassays represent the can select your own analytes and mix them yourself, or most flexible system of assays for the Luminex platform on design the panel of your choice with our online Invitrogen™ the market. More than 90% of our ProcartaPlex assays can ProcartaPlex™ Panel Configurator. Select your analytes of be combined with one another. A web-based design tool is interest and immediately receive recommendations for the now available for your made-to-order assays. most effective solutions for your panel needs. To design your own custom assay blend, go to thermofisher.com/customluminex

ProcartaPlex analytes ProcartaPlex analytes ProcartaPlex analytes Human Mouse Rat NHP Canine Porcine Human Mouse Rat NHP Canine Porcine Human Mouse Rat NHP Canine Porcine 4-1BB (CD137) ✓ Endoglin (CD105) ✓ ICAM-1 ✓ ✓ ✓ 4-1BBL (CD137L) ✓ Eotaxin (CCL11) ✓ ✓ ✓ ✓ IFN alpha ✓ ✓ ✓ ✓ Albumin* ✓ Eotaxin-2 (CCL24) ✓ IFN beta ✓ ✓ ✓ Adiponectin ✓ ✓ ✓ Eotaxin-3 (CCL26) ✓ IFN gamma ✓ ✓ ✓ ✓ ✓ ✓ Antithrombin* ✓ E-selectin (CD62E) ✓ IFN omega ✓ ✓ APRIL ✓ Factor V* ✓ IgA* ✓ ✓ ✓ BAFF ✓ ✓ Factor VII* ✓ IgE* ✓ ✓ BLC (CXCL13) ✓ ✓ Factor VIII* ✓ IgG1* ✓ ✓ ✓ BDNF ✓ ✓ Factor IX* ✓ IgG2* ✓ Betacellulin (BTC) ✓ Factor X* ✓ IgG2a* ✓ ✓ BTLA (CD272 ✓ Factor XI* ✓ IgG2b* ✓ ✓ C-peptide ✓ Factor XII* ✓ IgG2c* ✓ ✓ CD27 ✓ Factor XIII* ✓ IgG3* ✓ ✓ CD28 ✓ Fas (APO) ✓ IgG4* ✓ CD80 (B7-1) ✓ Fas-L ✓ IgM* ✓ ✓ ✓ Calcitonin ✓ FGF-2 ✓ ✓ IDO ✓ Caspase-3 (total) ✓ FGF-23 ✓ IL-1 alpha ✓ ✓ ✓ CD30 ✓ Fibrinogen ✓ I L-1 b e t a ✓ ✓ ✓ ✓ ✓ CD30L ✓ Fractalkine (CX3CL1) ✓ I L-1 R A ✓ ✓ CD40 ✓ Galectin-3 ✓ I L-2 ✓ ✓ ✓ ✓ ✓ CD40L ✓ ✓ GAPDH ✓ IL-2RA (CD25) ✓ ✓ CD44var (6var) ✓ G-CSF (CSF-3) ✓ ✓ ✓ ✓ I L- 3 ✓ ✓ CRP ✓ ✓ ✓ GITRL ✓ I L- 4 ✓ ✓ ✓ ✓ ✓ ✓ Clusterin* ✓ GITR (CD357) ✓ I L- 5 ✓ ✓ ✓ ✓ CTACK (CCL27) ✓ GM-CSF ✓ ✓ ✓ ✓ I L- 6 ✓ ✓ ✓ ✓ ✓ ✓ CTLA-4 (CD152) ✓ Granzyme B ✓ ✓ I L-7 ✓ ✓ ✓ Cortisol ✓ GRO alpha (KC/CXCL1) ✓ ✓ ✓ IL-7RA (CD127) ✓ Cysistin C* ✓ GLP-1 ✓ IL-8 (CXCL8) ✓ ✓ ✓ ✓ D-Dimer ✓ Ghrelin ✓ I L- 9 ✓ ✓ DR6 ✓ HER-2 ✓ I L-10 ✓ ✓ ✓ ✓ ✓ ✓ EDA-1 ✓ HGF ✓ I L-12 / I L-23 p 4 0 ✓ ✓ ✓ ✓ ✓ ✓ EGF ✓ HVEM (CD270) ✓ I L-12 p70 ✓ ✓ ✓ ✓ ENA-78 (CXCL5) ✓ ✓ Insulin ✓ I L-13 ✓ ✓ ✓ ✓

* Analytes only available as part of a panel.

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No Luminex instrument available? Sending us your samples Benefits of our custom assay service: can help save you time and money. Our service team • Enables you to obtain reproducible, quantitative data consists of highly skilled and experienced professionals from a small volume who will work with you throughout the stages of your project to help ensure delivery of high-quality data • Receive high-quality assay/data reports created and results. by experienced professionals

• Eliminate the need to buy a Luminex instrument

• Free up time and resources to focus on other projects

ProcartaPlex analytes ProcartaPlex analytes ProcartaPlex analytes Human Mouse Rat NHP Canine Porcine Human Mouse Rat NHP Canine Porcine Human Mouse Rat NHP Canine Porcine I L-15 ✓ ✓ MIG (CXCL9) ✓ ✓ RANTES (CCL5) ✓ ✓ ✓ ✓ I L-15/ I L-15 R ✓ MIP-1 alpha (CCL3) ✓ ✓ ✓ ✓ Resistin (ADSF) ✓ ✓ I L-16 ✓ MIP-1 beta (CCL4) ✓ ✓ ✓ SAA ✓ IL-17A (CTLA-8) ✓ ✓ ✓ ✓ MIP-2 alpha (CXCL2) ✓ ✓ SAP (Pentraxin 2) ✓ I L-17A F ✓ MIP-3 alpha (CCL20) ✓ SCF ✓ ✓ ✓ I L-17F ✓ ✓ ✓ MMP-1 ✓ SCGF beta ✓ I L-18 ✓ ✓ ✓ MMP-2 ✓ SDF-1 alpha (CXCL12a) ✓ ✓ I L-19 ✓ MMP-3 ✓ ST2 (IL-33R) ✓ I L-20 ✓ MMP-7 ✓ Survivin (BIRC5) ✓ I L-21 ✓ ✓ MMP-8 ✓ TGF alpha ✓ ✓ I L-2 2 ✓ ✓ MMP-9 ✓ TGF beta 1 ✓ ✓ ✓ ✓ ✓ ✓ I L-23 ✓ ✓ ✓ MMP-12 ✓ (TPO) ✓ I L-25 ✓ MMP-13 ✓ TIM-3 (CD366) ✓ IL-27 ✓ ✓ Myeloperoxidase (MPO) ✓ TIMP-1 ✓ ✓* IL-29 (IFN lambda 1) ✓ NGAL ✓ ✓* TFF-3* ✓ I L- 31 ✓ ✓ NGF beta ✓ ✓ ✓ ✓ TNF alpha ✓ ✓ ✓ ✓ ✓ ✓ I L- 3 3 ✓ ✓ (OSM) ✓ TNF beta ✓ ✓ I L- 37 ✓ Osteopontin ✓ ✓* TNF R1 ✓ IP-10 (CXCL10) ✓ ✓ ✓ ✓ Osteoprotegerin (OPG) ✓ TNF R2 ✓ I-TAC (CXCL11) ✓ ✓ PAI-1 (Serpin) ✓ ✓ Tissue Plasmon Activator ✓ KIM-1* ✓ PDGF-BB ✓ ✓ TRAIL ✓ ✓ LAG-3 ✓ PD-1 (CD279) ✓ T R A I L- R1 ✓ LAP (TGF beta 1) ✓ PD-L1 (CD274) ✓ TRAIL-R2 ✓ Leptin ✓ ✓ ✓ PD-L2 ✓ TSLP ✓ ✓ Light ✓ PECAM-1 ✓ Tweak ✓ LIF ✓ ✓ PIGF ✓ VCAM-1 ✓ ✓ ✓ L-selectin ✓ Protein C* ✓ VEGF-A ✓ ✓ ✓ ✓ ✓ MCP-1 (CCL2) ✓ ✓ ✓ ✓ ✓ * ✓ VEGF-D ✓ ✓ MCP-2 (CCL8) ✓ Prothrombin* ✓ VEGF-R1 ✓ MCP-3 (CCL7) ✓ ✓ ✓ ✓ P-selectin ✓ VEGF-R2 ✓ M-CSF ✓ ✓ PYY ✓ VEGF-R3 ✓ MDC (CCL22) ✓ RBP4 ✓ vWF* ✓ MIF ✓ ✓ RANKL ✓ ✓ ✓ ZAG ✓

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