Assay Menu & Statement of Qualifications

Your Global Biomarker Laboratory

ASSAY MENU & STATEMENT OF QUALIFICATIONS

ISSUE DATE AUG 25 , 2017

PREPARED FOR OUR VALUED CLIENTS

EVE TECHNOLOGIES CORP HRIC 3A26 3330 Hospital Dr., N. W. Calgary, AB. Canada T2N 4N1

Eve Technologies 1 Your Global Biomarker Laboratory

General Overview

Eve Technologies offers the most affordable assay services in the world for biomedical and life science researchers, and pharmaceutical companies. Our assay services facilitate protein analysis and drug discovery by providing reproducible, quantitative immunoassay data from a small sample volume. We utilize multiplex assay platforms such as the Bio-Plex Suspension Array System and the Milliplex platform. Our target analyte menu offers hundreds of multiplexing targets under various categories such as Cytokines, Chemokines, Cardio Markers, Cancer Markers, and Neuroscience Markers.

Key Service

• Assay Service and Results • 800+ Targets (See below) • Species include Human, Mouse, Rat, Porcine, Canine, Feline, and Primate • Discovery Assay - Lowest price per analyte in the industry • Custom Multiplex options

Why Eve Technologies?

Experience

With over 15 years of experience providing the world’s leading researchers with assay services and results, Eve Technologies has been instrumental in hundreds of published papers in some of the most respected journals. Eve Tech has become a leader in the industry assisting over 1000 research institutions with the best solutions for their projects. Our Assay service has become an important component in cost control in a research environment where money is hard to come by. Along with cost savings, Eve Technologies maintains high quality services on reputable assays.

Expertise

Specializing in Millipore (Milliplex) and Bio-Rad (Bio-Plex) systems these systems allow for Eve to perform up to 100 bioassays simultaneously on a single sample, these assays are efficient, cost effective and have high accuracy ratings.

People

Enough cannot be said about the employees of Eve Tech. Intelligent and committed, our staff takes pride in both what they do and their contribution to the research community. The team is composed of scientific professionals committed to the success of our client’s projects large or small. Please refer to our “Proposal” document or website for our profiles.

Analyte By Category

• Acute Phase Proteins •Diabetes and Obesity • Adipokine / Adipocyte •Endocrine • Angiogenesis •Gut Hormone • Apoptosis •Inflammation & Immunology • Autoimmune / Immunology •Isotyping • Bone Metabolism •Liver Biomarkers • Cancer Biomarkers •Kidney Biomarkers • Cardiovascular Disease •Metabolic Markers • Cellular Metabolism •Matrix Metallo-Proteinases • Cell Signaling •Neuroscience • Cytokines, Chemokines and Growth Factors •Pituitary and Thyroid

2 Eve Technologies TABLE OF CONTENTS

iscovery D ® DISCOVERY ASSAY 04 A s s a y 07 AP ASSAY PANELS 18 HUMAN 25 RAT 27 MOUSE 30 PRIMATE 31 FELINE 32 PORCINE 33 CANINE 34 CONTACT

Eve Technologies 3 ROUTINE DISCOVERY ASSAYS

EGF IL-10 sCD30 sIL-6R Eotaxin-1 IL-12(p40) Human sEGFR sRAGE FGF-2 IL-12(p70) Soluble Cytokine sgp130 sTNFRI Flt-3L IL-13 Receptors sIL-1RI sTNFRII Fractalkine IL-15 14-Plex Array Discovery Price sIL-1RII sVEGFR1 G-CSF IL-17A $23.99/sample sIL-2Ra sVEGFR2 GM-CSF IL-18 sIL-4R sVEGFR3 GRO(pan) IP-10 IFNα2 MCP-1 Human { IFN MCP-3 MMP-1 MMP-12 Cytokine / Ɣ Chemokine IL-1α MDC MMP-2 MMP-13 42-Plex Array IL-1β MIP-1α Human MMP-3 TIMP-1 Discovery Price IL-1ra MIP-1β MMP & TIMP Array MMP-7 TIMP-2 $46.95/sample IL-2 PDGF-AA 13-Plex Array MMP-8 TIMP-3 Discovery Price IL-3 PDGF-AB/BB $23.95/sample MMP-9 TIMP-4 IL-4 RANTES MMP-10 IL-5 sCD40L IL-6 TGFα { IL-7 TNFα

IL-8 TNFβ BDNF PDGF-AA IL-9 VEGF-A Human Cathepsin D PDGF-AB/BB Supplemental MPO RANTES Array NCAM sICAM-1 6Ckine IL-33 10-Plex PAI-1(total) sVCAM-1 BCA-1 LIF Discovery Price $21.59/sample {CTACK MCP-2 Human ENA-78 MCP-4 Secondary 23 Eotaxin-2 MIP-1d { Plex Array Angiopoietin-2 HB-EGF Combine with a Eotaxin-3 SDF-1α+β 41-Plex to make a I-309 SCF BMP-9 HGF 64-Plex EGF IL-8 Discovery Price IL-16 TARC Endoglin Leptin $26.95/sample IL-20 TPO Human IL-21 TRAIL Angiogenesis Endothelin-1 PlGF IL-23 TSLP 17-Plex Array FGF-1 VEGF-A Discovery Price FGF-2 VEGF-C IL-28A $25.19/sample Follistatin VEGF-D { { G-CSF GM-CSF IL-8 Human Adiponectin Lipocalin-2 /NGAL Human IFN฀ IL-10 Adipokine Cytokine Adipsin Resistin IL-1β IL-12(p70) (Serum/Plasma) Proinﬂammatory IL-2 IL-13 5-Plex Array PAI-1(total) 13-Plex Array Discovery Price Discovery Price IL-4 MCP-1 $17.39/sample $23.99/sample IL-5 TNF-α { { IL-6 4 Eve Technologies Eotaxin IL-13 G-CSF IL-15 GM-CSF IL-17A C-Peptide Insulin Human IFNƔ IP-10 Ghrelin Leptin Metabolic IL-1α KC 9-Plex Array GIP MCP-1 IL-1β LIF Discovery Price GLP-1 (active) PYY (total) Mouse $20.79/sample IL-2 LIX (unvalidated) Glucagon Cytokine / Chemokine IL-3 MCP-1 31-Plex Array IL-4 M-CSF Discovery Price IL-5 MIG $35.95/sample { IL-6 MIP-1α IL-7 MIP-1β GM-CSF IL-8 IL-9 MIP-2 Human IFNy IL-10 IL-10 RANTES High Sensitivity IL-1B IL-12p70 IL-12(p40) TNFα T-Cell Discovery IL-2 IL-13 Array 14-plex IL-12(p70) VEGF Discovery Price IL-4 IL-17A $24.69/sample IL-5 IL-23 IL-6 TNF-a { { EPO MDC 6Ckine MCP-5 Mouse Fractalkine MIP-3a TGF-β1 Cytokine Array / TGF-beta 3-Plex IFNB1 MIP-3B (Multi-Species) TGF-β2 Chemokine Array 13-plex Secondary IL-11 TARC 3-Plex Array TGF-β3 Discovery Price Panel IL-16 TIMP-1 Discovery Price $16.39/sample IL-20 { $23.99/sample {

Steroid/Thyroid IL-17A IL-27 for non-blood IL-17E IL-28B based samples Mouse Cortisol IL-17F IL-31 (STTD-Cell/ Mouse Th17 Tissue) Estradiol 11-Plex IL-21 IL-33 (Multi-Species) Progester- Discovery Price IL-22 MIP-3a 5-Plex Array $22.19/sample IL-23 Discovery Price T3 $19.99/sample { T4 { GM-CSF IL-6 Steroid/ Thyroid for IFNy IL-10 Cortisol Serum, Plasma, Mouse IL-1B IL-12p70 Whole blood Estradiol Cytokine Array Proin- flammatory Focused IL-2 MCP-1 (STTHD-Serum/ Progester- Plasma) 10-plex IL-4 TNF-a (Multi-Species) T3 Discovery Price 5-Plex Array T4 $21.99/sample Discovery Price Price includes special $31.99/sample { extraction step. { Eve Technologies 5 MMP-2 MMP-2 Mouse MMP-3 Mouse MMP-3 MMP Discovery Array MMP-8 MMP Discovery Array MMP-8 5-plex 5-plex (Serum & Plasma) proMMP-9 (Cell Culture and non- proMMP-9 Discovery Price MMP-12 blood samples) MMP-12 $17.39/sample Discovery Price { $17.39/sample {

Eotaxin IL-12(p70) EGF IL-13

Fractalkine IL-17A Amylin (active)* Insulin G-CSF IL-18 C-Peptide 2 Leptin GM-CSF IP-10 GIP(total) PP Mouse and Rat Rat GRO/KC Leptin GLP-1(active)* PYY Metabolic Array Cytokine / IFN LIX Ɣ Resistin Chemokine 11-Plex Array Ghrelin(active)* (Mouse Only) 27-Plex Array IL-1α MCP-1 Discovery Price Discovery Price IL-1β MIP-1α $22.19/sample Glucagon* $31.95/sample IL-2 MIP-2 * Inhibitors Recommended IL-4 RANTES { IL-5 TNF-α IL-6 VEGF {IL-10 GM-CSF IL-6

IFNƔ IL-8 Porcine IL-1α IL-10 Cytokine IL-1β IL-12 13-Plex Array Discovery Price IL-1ra IL-18 $23.99/sample IL-2 TNF-α { IL-4

For a full list of our Discovery Assay’s please see our website No Minimum Sample Order

6 Eve Technologies Choose your Assay Send your Sample Get Results! HUMAN

Human Cytokine/Chemokine Human Th17 Immunology Panel IV GM-CSF IL-17E / IL-25 Human Cytokine/Chemokine APRIL / TNFSF13 IL-28B / IFNλ3 IFNγ IL-17F Panel I BAFF / Blys IL-32α IL-1β IL-21 BRAK / CXCL14 IL-34 IL-2 IL-22 CCL28 IL-35 IL-4 IL-23 sCD40L IL-9 CXCL16 IL-36β / IL-1F8 IL-5 IL-27 EGF ♦ IL-10 ♦ HCC-4 / CCL16 IL-37 / IL-1F7 IL-6 IL-28A / IFNλ2 Eotaxin / CCL11 ♦ IL-12 (p40) ♦ HMGB1 ● IL-38 / IL-1F10 IL-9 IL-31 FGF-2 / FGF-basic IL-12 (p70) ♦ IL-10 IL-33 / NF-HEV ♦ IFNβ MIP-4 / PARC / CCL18 Flt3 Ligand IL-13 (mature) IL-14 / α-Taxilin MPIF / CCL23 IL-12 (p70) Fractalkine / CX3CL1 IL-15 ♦ IL-13 MIP-3α / CCL20 ♦ ♦ IL-19 YKL40/CHI3L1 G-CSF IL-17A / CTLA8 TNFα IL-24 IL-15 GM-CSF ♦ IP-10 / CXCL10 ♦ IL-17A / CTLA8 TNFβ/Lymphotoxinα GRO MCP-1 / CCL2 ♦ (LTA) IFNα2 ♦ MCP-3 / CCL7 Human High Sensitivity IFNγ ♦ MDC / CCL22 Human CD8+ T Cell IL-1α ♦ MIP-1α / CCL3 ♦ T Cell IL-1β ♦ MIP-1β / CCL4 ♦ IL-1Ra ♦ PDGF-AA ▲ Fractalkine / CX3CL1 IL-12 (p70) ♦ sCD137/4-1BB/ IL-4 IL-2 ♦ PDGF-AB / BB ▲ TNFRSF9 GM-CSF ♦ IL-13 ♦ IL-5 IL-3 ♦ RANTES / CCL5 ♦▲ sFAS / TNFRSF6 IFNγ ♦ IL-17A / CTLA8 IL-6 IL-4 ♦ TGFα sFasL IL-1β ♦ IL-21 IL-10 IL-5 ♦ TNFα ♦ GM-CSF IL-2 ♦ IL-23 IL-13 IL-6 ♦ TNFβ / Lymphotoxin-A Granzyme A IL-4 ♦ I-TAC / CXCL11 MIP-1α / CCL3 IL-7 ♦ (LTA) ♦ Granzyme B MIP-1β / CCL4 VEGF-A ♦ IL-5 ♦ MIP-1α / CCL3 IL-8 / CXCL8 ♦ IFNγ IL-6 ♦ MIP-1β / CCL4 Perforin IL-2 IL-7 ♦ MIP-3α / CCL20 TNFα IL-8 / CXCL8 ♦ TNFα ♦ IL-10 ♦ Human Cytokine/Chemokine Human Complement Panel 1 Panel II Human Soluble Cytokine Receptor Adipsin/Factor D C5a C2 C9 6Ckine/CCL21/ IL-28A/IFNλ2 C4b Factor I Exodus-2 IL-33/NF-HEV C5 Mannose-binding BCA-1/CXCL13 (mature) sCD30 sIL-6R CTACK/CCL27 LIF sEGFR sRAGE Lectin (MBL) ENA-78/CXCL5 MCP-2/CCL8 sgp130 sTNF RI Eotaxin-2/CCL24/ MCP-4/CCL13 sIL-1RI sTNF RII Human Complement Panel 2 MPIF-2 MIP-1δ/MIP-5/CCL15 sIL-1RII sVEGFR1 / sFlt-1 Eotaxin-3/CCL26 sVEGFR2 / sKDR / sFlk-1 SCF sIL-2Rα I-309/CCL1 SDF-1/CXCL12 sVEGFR3 / sFlt-4 sIL-4R C1q Factor B IL-16 TARC/CCL17 C3 Factor H IL-20 TPO C3b / iC3b Factor P/Properdin IL-21 TRAIL/TNFSF10 C4 IL-23 TSLP Human MMP Panel 1 Human Cytokine/Chemokine Panel III MMP-3 MMP-13 MMP-12

HCC-1 / CCL14 ▲ M-CSF/CSF-1 Human MMP Panel 2 IL-11 MIG / CXCL9 IL-29 / IFNλ1 MIP-3α / CCL20 I-TAC / CXCL11 MIP-3β / CCL19 MMP-1 MMP-9 LIX / CXCL6 / GCP-2 NAP-2 / CXCL7 ▲ MMP-2 MMP-10 Lymphotactin / XCL1 MMP-7

Eve Technologies 7 Human TIMP Panel 1 Human Skin (Serum/Plasma samples) (Skin extracts only) Human Diabetes ▼

NON-CONFIGURABLE KIT TIMP-1 TIMP-2 Cortisol ^ Involucrin Fibronectin Keratin-1,10 C-Peptide Insulin Human Serum Keratin-6 GLP-1 (active) ◗ Leptin Albumin (HSA) Glucagon ◗ Human TIMP Panel 2 (Cell culture samples)

TIMP-1 TIMP-3 Human Immunoglobulin Human Metabolic Hormone TIMP-2 TIMP-4 Isotyping Amylin (active) † ◗ IL-6 IgA IgG3 Amylin (total) † ◗ Insulin IgG1 IgG4 C-Peptide Leptin ◗ Multi-Species TGFβ – IgG2 IgM Ghrelin (active) MCP-1/CCL2 GIP (total) Pancreatic Singleplex GLP-1 (active) † ◗ Polypeptide (PP) GLP-1 (total) † ◗ PYY (total) TGFβ1 Human IgE – Singleplex Glucagon ◗ TNFα

IgE

Multi-Species TGFβ – 3 Plex Human Myokine ▼ Metabolism/ Apelin IL-15 TGFβ1 TGFβ3 BDNF Irisin TGFβ2 Endocrinology Erythropoietin (EPO) LIF FABP3 Myostatin/GDF8 Human Adipokine Panel FGF21 Oncostatin-M (OSM) 1 (Serum/Plasma samples) Fractalkine/CX3CL1 Osteocrin/Musclin Immune Response FSTL1 Osteonectin/SPARC Adiponectin PAI-1 (total) IL-6 Adipsin/Factor D Resistin Human Sepsis Panel 1 NGAL/Lipocalin-2

sFAS / TNFRSF6 MIF Human Liver Protein sFasL PAI-1 (total) Human Adipokine Panel sICAM-1 sVCAM-1 α-Fetoprotein (AFP) FGF-19 2 (Serum/Plasma samples) ANGPTL3 FGF-21 ANGPTL4 FGF-23 HGF Leptin ANGPTL6 HGF Human Sepsis Panel 2 IL-1β MCP-1/CCL2 FABP1 IL-6 NGF Granzyme B MIP-1α / CCL3 IL-8/CXCL8 TNFα HSP70 MIP-1β / CCL4 Insulin IL-1α MMP-8 Human IGF Binding Protein IL-8 / CXCL8

IGFBP1 IGFBP5 Human Adipocyte IGFBP2 IGFBP6 (Cell culture samples) Human Sepsis Panel 3 IGFBP3 IGFBP7 IGFBP4 Adiponectin MCP-1/CCL2 Lactotransferrin (LTF) Resistin HGF NGF Neutrophil Elastase-2 Thrombospondin-1 IL-1β PAI-1 (total) (ELA2) (TSP-1) IL-6 Resistin Human IGF ■ NGAL/Lipocalin-2 IL-8/CXCL8 TNFα Leptin IGF-1 IGF-2

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† Analytes which cannot be plexed together: ◗ Requires a protease inhibitor during Available for custom premix – Active and total sample collection ●● Can be plexed with other 2 Plexes – Free and total ■ Requires sample extraction H Human ♦ Available in Cat. No. listed ● Serum/Plasma only M Mouse ▲ These analytes cannot be plexed with other ★ Tissue Culture samples only R Rat analytes in this panel in serum/plasma ^ Competitive assay format ▼ Premix panel only

8 Eve Technologies Human Pituitary Panel 1 Human CVD Panel 5 Human Circulating Cancer Biomarker Panel 2 ACTH FSH ADAM15 Leptin Receptor (LEPR) Agouti-Related GH Cadherin 13 (CDH13) MR-ProADM Antithrombin III Extracellular Matrix Protein (AgRP) LH sCD163 Notch1 Complement Factor Protein 1 (ECM1) CNTF TSH Chromogranin-A PLA2G7 H (CFH) Vitamin D Binding (CHGA/CGA) PTGDS Protein HSP60 sST2/IL1RL1 IGF1R Syndecan 4 (SYND4) Multi-Species Steroid/ LDLR Human Circulating Cancer Thyroid Hormone ■ ^ Biomarker Panel 3

Cortisol T3 Estradiol T4 Human Apolipoprotein Cathepsin D Melanoma Inhibitory Activity (MIA) Progesterone Ferritin Apo AI Apo CII Fibroblast Activation Myeloperoxidase (MPO) Apo AII Apo CIII Protein (FAP) Galectin 3 Sex Hormone Binding Apo B Apo E Globulin (SHBG) IGFBP3 Cardiovascular

Human CVD Panel 1 Bone Human Circulating Cancer

BNP LIX/CXCL6/GCP-2 Biomarker Panel 4 Human Bone CK-MB NT proBNP ALDH1A1 Kallikrein-6 CXCL16 Oncostatin (OSM) Carbonic Anhydrase Mesothelin Endocan-1 (ESM-1) Placental Growth ACTH Osteocalcin (OC) 9 (CA9) Midkine FABP3 Factor (PLGF) DKK1 Osteopontin (OPN) CD44 NCAML1/L1CAM/ FABP4 Troponin I (TnI) FGF-23 Osteoprotegerin (OPG) EpCAM CD171 LIGHT IL-1β PTH Hepsin Transglutaminase 2 IL-6 Sclerostin (SOST) (TGM2) Insulin TNFα Leptin Human CVD Panel 2 Human Cancer/Metastasis ADAMTS13 Myoglobin Biomarker Panel 1 Human RANKL – Singleplex D-dimer NGAL/Lipocalin-2 GDF-15 sP-Selectin DKK1 Osteoprotegerin RANKL sICAM-1 Serum Amyloid A GDF15 (OPG) Myeloperoxidase sVCAM-1 Neuron-specific Periostin (MPO) Enolase (NSE) TRAP5 Osteonectin (SPARC) TWEAK Cancer YKL40/1CHI3L1 Human CVD Panel 3 (Acute Phase) Human Circulating Cancer Biomarker Panel 1 Human Angiogenesis/Growth α1-Acid Glycoprotein Haptoglobin Factor Panel 1 (AGP) sL-Selectin α-Fetoprotein (AFP) IL-8/CXCL8 α-2-Macroglobulin Platelet Factor 4 CA125 Leptin Angiopoietin-2 HB-EGF Adipsin/Factor D (PF4/CXCL4) CA15-3 MIF BMP-9 HGF CRP Serum Amyloid P CA19-9 Osteopontin (OPN) EGF IL-8/CXCL8 Fetuin A von Willebrand Factor CEA Prolactin Endoglin Leptin Fibrinogen (vWF) CYFRA21-1 PSA (free)† Endothelin-1 Placental Growth sFas PSA (total)† FGF-1/FGF-acidic Factor (PLGF) sFasL/TNFRSF6 SCF FGF-2/FGF-basic VEGF-A Human CVD Panel 4 FGF-2/FGF-basic TGFα Follistatin (FST) VEGF-C HCGβ TNFα G-CSF VEGF-D HE4 TRAIL/TNFSF10 sCD31/sPECAM-1 sE-Selectin HGF VEGF-A dPAPP-A Thrombomodulin IL-6 Follistatin (FST) Tissue Factor (TF) Pentraxin-3 (PTX3) Troponin T (TnT)

Eve Technologies 9 Human Angiogenesis Panel 2 Human Neurodegenerative Human Kidney Injury Panel Disease Panel 3 2 (Urine samples) Angiostatin/Kringle sIL-6Rα sAXL sNeuropilin-1 (sNRP-1) BDNF PAI-1 (total) α-1-Microglobulin EGF sCD31/sPECAM-1 Osteopontin (OPN) Cathepsin D PDGF-AA Albumin NGAL/Lipocalin-2 sc-Kit/sStem Cell PDGF-AB/BB sICAM-1 PDGF-AB/BB Clusterin Osteopontin (OPN) Factor Receptor Tenascin C (TN-C) Myeloperoxidase RANTES/CCL5 Cystatin C (SCFR) Thrombospondin-2 (MPO) sVCAM-1 sE-Selectin (TSP-2) sNCAM sEGFR/sHER1/sErbB1 sTIE-2 sHER2/sEGFR2/ suPAR Human Kidney Injury Panel sErbB2 sVEGFR1/sFlt1 3 (Urine samples) sHER3/sEGFR3/ Human Neurodegenerative sErbB3 sVEGFR2/sKDR/sFlk-1 Disease Panel 4 β-2-Microglobulin Uromodulin sHGFR/sc-Met sVEGFR3/sFlt-4 (CSF samples) RBP4

Amyloid beta 1-40 sRAGE Amyloid beta 1-42 S100B Human Kidney Injury Panel 4 Neuroscience GDNF (Serum/Plasma samples)

Human Amyloid Beta and Tau EGF Osteopontin (OPN) (CSF samples) Human Neurological FABP1 PTH Disorders Panel 3 IP-10/CXCL10 Renin Amyloid beta 1-40 pTau (Thr181) KIM-1 Amyloid beta 1-42 Tau (total) Angiotensinogen Osteopontin (OPN) (AGT) Soluble Superoxide Contactin-1 Dismutase 1 (sSOD1) Human Kidney Injury Panel Human Neuroscience Panel Fetuin A Soluble Superoxide 5 (Serum/Plasma samples) Kallikrein-6 Dismutase 2 (sSOD2) 1 (CSF samples) α-1-Microglobulin Osteoactivin α-Synuclein PARK5/UCHL1 Collagen IV TIMP-1 Glial Fibrillary Acidic PARK7/DJ1 Human Neuropeptide ■ ^ NGAL/Lipocalin-2 Uromodulin Protein (GFAP) Transglutaminase 2 Neuron-Specific (TGM2) Enolase (NSE) α-MSH Orexin A β-Endorphin Oxytocin Human Kidney Injury Panel 6 Neurotensin Substance P (Serum/Plasma samples) Human Neurodegenerative Disease Panel 1 β-2-Microglobulin Cystatin C Human Circadian Stress ■ ^ Clusterin RBP4

α-2-Macroglobulin Apo E Apo AI Complement C3 Cortisol Melatonin Apo CIII Complement Factor H Human Liver Injury

5'NT/CD73 MDH1 Human Neurodegenerative Toxicity ARG1 SDH Disease Panel 2 GSTα Human Kidney Injury Panel 1 α-1-Antitrypsin (A1AT) MIP-4/PARC/CCL18 (Urine samples) C4 PEDF Calbindin KIM-1 CRP Serum Amyloid P (SAP) Collagen IV Osteoactivin FABP1 Renin GSTα TFF-3 IP-10/CXCL10 TIMP-1

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10 Eve Technologies PRIMATE Metabolism Mouse Cytokine/Chemokine Immunology Non-Human Primate Panel 2 Metabolic Hormone

Non-Human Primate Erythropoietin (EPO) IL-17A/F Amylin (active) ◗ Insulin Cytokine/Chemokine Panel 1 Exodus-2/ IL-20 C-Peptide Leptin CCL21/6Ckine MDC/CCL22 Ghrelin (active) ◗ MCP-1/CCL2 Fractalkine/CX3CL1 MCP-5/CCL12 sCD40L IL-12/23 (p40) GIP (total) Pancreatic IFNβ1 MIP-3α/CCL20 GLP-1 (active) ◗ Polypeptide (PP) G-CSF IL-13 IFNγ PYY (total) MIP-3β/CCL19 GM-CSF IL-15 Glucagon ◗ IL-11 TARC/CCL17 IFNγ IL-17A/CTLA8 IL-6 IL-16 TIMP-1 IL-1β IL-18 IL-1Ra MCP-1/CCL2 Non-Human Primate Pituitary Mouse High Sensitivity T Cell IL-2 MIP-1α/CCL3 Panel 1 IL-4 MIP-1β/CCL4 IL-5 TGFα GM-CSF IL-10 ACTH FSH IL-6 TNFα IFNγ IL-12 (p70) Agouti-Related GH IL-8/CXCL8 VEGF-A IL-1α IL-13 Protein (AgRP) LH IL-10 IL-1β IL17A/CTLA8 CNTF TSH IL-2 KC/GROα/CXCL1 Non-Human Primate IL-4 LIX Cytokine/Chemokine Panel 2 Multi-Species Steroid/Thyroid IL-5 MCP-1/CCL2 Hormone ■ ^ IL-6 MIP-2/CXCL2 IL-7 TNFα

sCD137/4-1BB/ IL-17E/IL-25 Cortisol T3 TNFRSF9 Mouse Soluble Cytokine IL-21 Estradiol T4 Eotaxin/CCL11 Receptor IL-22 Progesterone sFasL/TNFRSF6 IL-23 FGF-2/FGF-basic IL-28A/IFNλ2 sCD30 sRAGE Fractalkine/CX3CL1 MOUSE IL-31 sGP130 sTNF RI Granzyme A IL-33/NF-HEV sIL-1RI sTNF RII Granzyme B (mature) sIL-1RII sVEGFR1/sFlt-1 IL-1α IP-10/CXCL10 Immunology sIL-2Rα sVEGFR2/sKDR/sFlk-1 IL-2 MIP-3α/CCL20 sIL-4R sVEGFR3/sFlt-4 IL-4 Perforin Mouse Cytokine/Chemokine sIL-6R IL-6 RANTES/CCL5 ▲ Panel I IL-16 TNFβ/Lymphotoxinα IL-17A/CTLA8 Mouse Th17 (LTA) Eotaxin/CCL11 IL-13 ♦ ♦ ♦ Multi-Species TGFβ – G-CSF IL-15 GM-CSF ♦ IL-17A/CTLA8 ♦ sCD40L IL-17E/IL-25 Singleplex IFNγ ♦ IP-10/CXCL10 ♦ GM-CSF IL-17F IL-1α ♦ KC/GROα/CXCL1 ♦ IFNγ IL-21 IL-1β IL-22 TGFβ1 IL-1β ♦ LIF IL-2 ♦ LIX IL-2 IL-23 IL-3 MCP-1/CCL2 ♦ IL-4 IL-27 ♦ M-CSF IL-5 IL-28B/IFNλ3 Multi-Species TGFβ – 3 Plex ▼ IL-4 /CSF-1 IL-5 ♦ MIG/CXCL9 IL-6 IL-31 NON-CONFIGURABLE KIT IL-6 ♦ MIP-1α/CCL3 ♦ IL-10 IL-33/NF-HEV (mature) IL-7 ♦ MIP-1β/CCL4 ♦ IL-12 (p70) TGFβ1 TGFβ3 MIP-3α/CCL20 IL-9 ♦ MIP-2/CXCL2 ♦ IL-13 TGFβ2 TNFα IL-10 ♦ RANTES/CCL5 ♦ IL-15 TNFβ/Lymphotoxinα IL-12 (p40) ♦ TNFα ♦ IL-17A/CTLA8 (LTA) IL-12 (p70) ♦ VEGF-A

Eve Technologies 11 Metabolism/ Mouse Myokine Endocrinology Mouse CD8+ T Cell BDNF Irisin Mouse Adipokine Erythropoietin (EPO) ★ LIF sCD137/4-1BB/ IL-4 (Serum/Plasma samples) FGF-21 Myostatin/GDF8 TNFRSF9 IL-5 Fractalkine/CX3CL1 Oncostatin-M (OSM) sFas/TNFRSF6 Osteocrin/Musclin IL-6 IL-6 PAI-1 (total) Follistatin-like sFasL (OSTN) IL-10 Insulin Resistin Protein 1 (FSTL-1) GM-CSF IL-6 IL-13 Leptin TNFα Osteonectin/SPARC Granzyme B MIP-1β/CCL4 MCP-1/CCL2 IL-15 IFNγ RANTES/CCL5 IL-2 Mouse Pituitary TNFα Mouse Adipocyte (Cell culture samples) Multi-Species TGFβ – ACTH LH Singleplex Adiponectin PAI-1 (total) BDNF Prolactin IL-6 Resistin FSH TSH Leptin TNFα GH TGFβ1 MCP-1/CCL2 Multi-Species Multi-Species TGFβ – 3 Plex ▼ Mouse Adiponectin – Steroid/Thyroid Hormone ■ ^ Singleplex NON-CONFIGURABLE KIT (Serum/Plasma samples) Cortisol T3 TGFβ1 TGFβ3 Estradiol T4 TGFβ2 Adiponectin Progesterone

Mouse MMP Panel 3 Mouse Gut Hormone (Cell culture samples) Cardiovascular

Amylin (active) ◗ Leptin Mouse CVD1 MMP-2 proMMP-9 Ghrelin (active) ◗ Pancreatic MMP-3 MMP-12 GIP (total) Polypeptide (PP) sCD31/sPECAM-1 PAI-1 (total) MMP-8 GLP-1 (active) ◗ PYY (total) sE-Selectin sP-Selectin Insulin Immune Response sICAM-1 Thombomodulin Mouse Metabolic Hormone proMMP-9 Mouse Immunoglobulin Mouse CVD2 Isotyping Amylin (active) ◗ Leptin C-Peptide 2 MCP-1/CCL2 IgA IgG2b sCD40L Oncostatin M Ghrelin (active) ◗ Pancreatic IgG1 IgG3 Polypeptide (PP) CXCL16 PLGF-2 GIP (total) IgG2a IgM PYY (total) Endocan-1 Troponin I GLP-1 (active) ◗ Resistin Follistatin Troponin T Glucagon ◗ TNFα LIGHT Mouse IgE – Singleplex IL-6 Insulin

IgE Mouse Acute Phase Panel 2

Adipsin/Factor D CRP α-1-Acid Glycoprotein Haptoglobin (AGP) Serum Amyloid P α-2-Macroglobulin

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12 Eve Technologies Rat Pituitary Bone Metabolism

Mouse Bone RAT ACTH LH BDNF Prolactin FSH TSH ACTH Leptin Immunology GH DKK1 Osteoprotegerin FGF-23 (OPG) IL-6 Sclerostin (SOST) Rat Cytokine/Chemokine Rat Stress Hormone ■ Insulin TNFα EGF IL-10 ACTH Melatonin^ Mouse Osteocalcin – Eotaxin / CCL11 IL-12 (p70) Corticosterone^ Singleplex Fractalkine / CX3CL1 IL-13 G-CSF IL-17A/CTLA8 GM-CSF IL-18 Multi-Species Osteocalcin (OC) GROα / KC / CINC- IP-10/CXCL10 Steroid / Thyroid Hormone ■ ^ 1 / CXCL1 Leptin Mouse RANKL – Singleplex IFNγ LIX Cortisol T3^ (Cat. No. MRNKLMAG-41K-01) IL-1α MCP-1/CCL2 Estradiol T4^ IL-1β MIP-1α/CCL3 RANKL Progesterone IL-2 MIP-2/CXCL2 IL-4 RANTES/CCL5 Rat Thyroid Cancer IL-5 TNFα IL-6 VEGF-A Mouse Angiogenesis / Growth T3^ TSH T4^ Factor Panel 1 Multi-Species TGFβ – Singleplex Cardiovascular sALK-1 IL-6 Amphiregulin IL-17A/CTLA8 TGFβ1 Rat Cardiac Injury Panel 1 Angiopoietin-2 ▲ KC/CXCL1 Betacellulin ▲ Leptin Multi-Species TGFβ – 3 Plex ▼ sCD31/sPECAM-1 ▲ MCP-1/CCL2 Cardiac Troponin I FABP3 (cTnI) EGF MIP-1α/CCL3 Follistatin-like Protein NON-CONFIGURABLE KIT Cardiac Troponin T 1 (FSTL1) Endoglin Placental Growth (cTnT) Factor (PLGF-2) TGFβ1 TGFβ3 Myosin Light Chain 3 Endothelin-1 Creatine Kinase (MYL3) Prolactin TGFβ2 sFasL/TNFRSF6 Muscle (CKM) TIMP-1 FGF-2/FGF-basic SDF-1/CXCL12 Follistatin (FST) TNFα Metabolism/ Rat Vascular Injury Panel VEGF-A G-CSF Endocrinology 1 (Serum/Plasma samples) HGF VEGF-C IL-1β VEGF-D Rat Adipokine Caveolin-1 IL-6 Neuroscience (Serum/Plasma samples) Connective Tissue MCP-1 / CCL2 Growth Factor PAI-1 (total) (CTGF) IL-1β MCP-1 / CCL2 TIMP-1 Mouse Neuropeptide ■ ^ GROα / KC / CINC- IL-6 PAI-1 (total) 1 / CXCL1 TNFα Insulin TNFα VEGF α-MSH Orexin A Leptin Rat Vascular Injury Panel β-Endorphin Oxytocin Neurotensin Substance P Rat Adipocyte 2 (Serum/Plasma samples) (Cell culture samples)

Toxicity Adiponectin sICAM-1 Adiponectin MCP-1/CCL2 sE-Selectin von Willebrand Factor (vWF) Mouse Kidney Injury Panel 1 IL-1β PAI-1 (total) IL-6 TNFα Leptin Rat Vascular Injury Panel β-2-Microglobulin Renin 3 (Serum/Plasma samples) IP-10/CXCL10 TIMP-1 Rat Metabolic Hormone KIM-1 VEGF-A α-1-Acid Glycoprotein Fibrinogen ▲ (AGP) Mouse Kidney Injury Panel 2 Amylin (active) ◗ Insulin Haptoglobin α-2-Macroglobulin C-Peptide 2 Leptin (A2M) Ghrelin (active) ◗ MCP-1/CCL2 Clusterin NGAL/Lipocalin-2 GIP (total) Pancreatic Cystatin C Osteopontin (OPN) GLP-1 (active) ◗ Polypeptide (PP) EGF Glucagon ◗ PYY (total) IL-6 TNFα

Eve Technologies 13 Bone Metabolism Multi-Species OTHER SPECIES Steroid/Thyroid Hormone ■ ^ Rat Bone Panel 1 (Serum/Plasma samples) Immunology Cortisol T3 Estradiol T4 Canine Cytokine/Chemokine Progesterone ACTH Leptin DKK1 Osteoprotegerin (OPG) FGF-23 PTH GM-CSF IL-15 Toxicity Insulin Sclerostin (SOST) IFNγ IL-18 IL-2 IP-10 / CXCL10 Canine Kidney Toxicity Neuroscience IL-6 KC-like Expanded Panel 1 IL-7 MCP-1 / CCL2 (Urine samples) Rat Neuropeptide ■ ^ IL-8 / CXCL8 TNFα IL-10 Clusterin MCP-1 / CCL2 α-MSH Orexin A Multi-Species TGFβ – Cystatin C NGAL / Lipocalin-2 β-Endorphin Oxytocin Singleplex IL-8 / CXCL8 Osteopontin (OPN) Neurotensin Substance P KIM-1 Toxicity TGFβ1 Canine Kidney Toxicity Panel 2 (Urine samples) Multi-Species TGFβ – 3 Plex ▼ Rat Kidney Toxicity Panel Albumin RBP4 1 (Urine samples) NON-CONFIGURABLE KIT β-2-Microglobulin TFF-3 TGFβ1 TGFβ3 Calbindin KIM-1 TGFβ2 Immunology Clusterin Osteopontin (OPN) GSTα^ TIMP-1 Metabolism/ Feline Cytokine/Chemokine IP-10 / CXCL10 VEGF-A Endocrinology NON-CONFIGURABLE KIT Rat Kidney Toxicity Panel 2 Canine Gut Hormone sFas IL-13 (Urine samples) Flt3 Ligand IL-18 GM-CSF KC/GRO IFNγ MCP-1 / CCL2 α-1-Acid Glycoprotein Cystatin C Amylin (total) ◗ Insulin IL-1β PDGF-BB (AGP) EGF Ghrelin (active) ◗ Leptin Albumin^ IL-2 RANTES / CCL5 NGAL / Lipocalin-2 GIP (total) Pancreatic β-2-Microglobulin GLP-1 (active) ◗ Polypeptide (PP) IL-4 SCF Glucagon PYY (total) IL-6 SDF-1 / CXCL12 Rat Liver Injury IL-8 / CXCL8 TNFα IL-12 (p40) Canine Pituitary 5'NT/CD73 GSTα ARG1 SDH ACTH GH GOT1 BDNF TSH FSH

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14 Eve Technologies Metabolism/ Multi-Species TGFβ – 3 Plex ▼ Multi-Species TGFβ – NON-CONFIGURABLE KIT Endocrinology Singleplex TGFβ1 TGFβ3 Feline Metabolic Hormone TGFβ2 TGFβ1

Amylin (active) ◗ Insulin Metabolism/ Multi-Species TGFβ - 3 Plex ▼ Ghrelin (active) ◗ Leptin

GIP (total) Pancreatic Endocrinology NON-CONFIGURABLE KIT GLP-1 (active) ◗ Polypeptide (PP) TGFβ1 TGFβ3 Glucagon ◗ PYY (total) Multi-Species Steroid/Thyroid TGFβ2 Hormone ■ ^ Multi-Species Steroid/Thyroid Metabolism/ Hormone ■ ^ Cortisol T3 Endocrinology Estradiol T4 Progesterone Cortisol T3 Multi-species Steroid/Thyroid Estradiol T4 Hormone ■ ^ Progesterone Immunology

Immunology Equine Cytokine/Chemokine Cortisol T3 Panel Estradiol T4 Progesterone Porcine Cytokine/Chemokine Eotaxin/CCL11 IL-6 FGF-2/FGF-basic IL-8/CXCL8 GM-CSF IL-6 Fractalkine/CX3CL1 IL-10 IFNγ IL-8/CXCL8 G-CSF IL-12 (p70) IL-1α IL-10 GM-CSF IL-13 IL-1β IL-12 GRO IL-17A/CTLA8 IL-1Ra IL-18 IFNγ IL-18 IL-2 TNFα IL-1α IP-10/CXCL10 IL-4 IL-1β MCP-1/CCL22 Multi-Species TGFβ - IL-2 RANTES/CCL5 IL-4 TNFα Singleplex IL-5

TGFβ1

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Eve Technologies 15 Cell Signaling

Akt/mTOR (Phosphoprotein) – 11 Plex Human DNA Damage/Genotoxicity – 7 Plex ▼ NON-CONFIGURABLE KIT ▼ NON-CONFIGURABLE KIT

Analyte Total Phosphorylated Analyte Total Phosphorylated Akt/PKB 3 (Ser473) H, M, R ATR 3 H GSK3α 3 (Ser21) H, M, R Chk1 3 (Ser345) H, M, R GSK3β 3 (Ser9) H, M, R Chk2 3 (Thr68) H IGF1R 3 (Tyr1135/1136) H, M H2A.X 3 (Ser139) H, M, R IR 3 (Tyr1162/1163) H MDM2 3 H, M, R IRS1 3 (Ser636) H, R p21 3 H mTOR 3 (Ser2448) H, M p53 3 (Ser15) H p70S6 Kinase 3 (Thr389/412) H, M, R PTEN 3 (Ser380) H, M, R MAPK/SAPK (Phosphoprotein) – 10 Plex RPS6 3 (Ser235/236) H, M, R ▼ NON-CONFIGURABLE KIT TSC2 3 (Ser939) H, M, R Analyte Total Phosphorylated ATF2 3 (Thr71) H, M Akt/mTOR (Total) – 11 Plex c-Jun 3 (Ser73) H, M, R ▼ NON-CONFIGURABLE KIT ErK/MAPK 1/2 3 (Thr185/Tyr187) H, M, R Analyte Total Phosphorylated HSP27 3 (Ser78) H Akt/PKB 3 H, M, R JNK/SAPK1 3 (Thr183/Tyr185) H, M, R GSK3α 3 H, M, R MEK1 3 (Ser222) H, M, R GSK3β 3 H, M, R MSK1 3 (Ser212) H, M IGF1R 3 H, M, R p38/SAPK2A/B 3 (Thr180/Tyr182) H, M, R IR 3 H, R p53 3 (Ser15) H IRS1 3 H, M, R STAT1 3 (Tyr701) H, M mTOR 3 H, M, R p70S6 Kinase 3 H, M, R Human RTK (Phosphoprotein) PTEN 3 H, M, R (Choose Analytes that Meet your Needs) RPS6 3 H, M, R TSC2 3 H, M, R Analyte Total Phosphorylated c-Kit (pan Tyr) H c-Met/HGFR (pan Tyr) H Early Apoptosis – 7 Plex EGFR (pan Tyr) H ▼ NON-CONFIGURABLE KIT ErbB2/HER2 (pan Tyr) H Analyte Total Phosphorylated ErbB3/HER3 (pan Tyr) H Akt/PKB 3 (Ser473) H, M, R ErbB4/HER4 (pan Tyr) H BAD 3 (Ser112) H FGFR1 (pan Tyr) H Bcl-2 3 (Ser70) H Flt3 (pan Tyr) H Active Caspase 8 3 H IGF1R (pan Tyr) H Active Caspase 9 3 H IR (pan Tyr) H JNK/SAPK1 3 (Thr183/Tyr185) H, M, R MSCFR (pan Tyr) H p53 3 (Ser46) H PDGFRα (pan Tyr) H, M, R PDGFRβ (pan Tyr) H TIE1 (pan Tyr) H TIE2 (pan Tyr) H VEGFR1/Flt-1 (pan Tyr) H VEGFR2/KDR/Flk-1 (pan Tyr) H VEGFR3/Flt-4 (pan Tyr) H, M, R

16 Eve Technologies Cell Signaling (continued)

Multi-Pathway (Phosphoprotein) — 9 Plex Src Family Kinase Active Site ▼ NON-CONFIGURABLE KIT (Phosphoprotein) — 8 Plex ▼ NON-CONFIGURABLE KIT Analyte Total Phosphorylated Akt/PKB 3 (Ser473) H, M, R Analyte Total Phosphorylated 3 CREB 3 (Ser133) H, M, R BLK (Tyr389) H 3 Erk/MAPK 1/2 3 (Thr185/Tyr187) H, M, R Fgr (Tyr412) H, R 3 JNK/SAPK1 3 (Thr183/Tyr185) H, M, R Fyn (Tyr420) H, M, R 3 NFκB 3 (Ser536) H HcK (Tyr411) H, M 3 p38/SAPK2A/B 3 (Thr180/Tyr182) H, M, R Lck (Tyr394) H, M, R 3 p70S6 Kinase 3 (Thr389/412) H, M, R Lyn (Tyr397) H, R 3 STAT3 3 (Ser727) H, M, R Src (Tyr419) H, M, R 3 STAT5A/B 3 (Tyr694/699) H, M, R Yes (Tyr421) H, M, R

Multi-Pathway (Total) — 9 Plex STAT (Phosphoprotein) — 5 Plex ▼ NON-CONFIGURABLE KIT NON-CONFIGURABLE KIT

Analyte Total Phosphorylated Analyte Total Phosphorylated 3 Akt/PKB 3 H, M, R STAT1 (Tyr701) H, M 3 CREB 3 H, M, R STAT2 (Tyr690) H 3 Erk/MAPK 1/2 3 H, M, R STAT3 (Tyr705) H, M, R 3 JNK/SAPK1 3 H, M, R STAT5A/B (Tyr694/699) H, M, R 3 NFκB 3 H, M, R STAT6 (Tyr641) H p38/SAPK2A/B 3 H, M, R T-Cell Receptor (Phosphoprotein) — 7 Plex p70S6 Kinase 3 H, M, R ▼ NON-CONFIGURABLE KIT STAT3 3 H, M, R Analyte Total Phosphorylated STAT5A/B 3 H, M, R CD3ε 3 (pan Tyr) H NFκB — 6 Plex CREB 3 (Ser133) H, M, R ▼ NON-CONFIGURABLE KIT Erk/MAPK 1/2 3 (Thr185/Tyr187) H, M, R 3 Analyte Total Phosphorylated LAT (pan Tyr) H 3 c-Myc 3 H Lck (pan Tyr) H, M, R 3 FADD 3 (Ser194) H Syk (pan Tyr) H 3 IκBα 3 (Ser32) H ZAP-70 (pan Tyr) H IKKα/β 3 (Ser177/181) H TGFβ — 6 Plex NFκB 3 (Ser536) H, M ▼ NON-CONFIGURABLE KIT TNFRI 3 H Analyte Total Phosphorylated Protein Translation — 6 Plex Akt/PKB 3 (Ser473) H ▼ NON-CONFIGURABLE KIT Erk/MAPK 1/2 3 (Thr185/Tyr187) H, M, R

Analyte Total Phosphorylated SMAD2 3 (Ser465/467) H, M, R elF2a 3 (Ser51) H, M, R SMAD3 3 (Ser423/425) H, M, R 3 elF-4B 3 (Ser422) H, M, R SMAD4 H, M, R 3 elF-4E 3 (Ser209) H, M, R TGFβRII H elF-4G 3 (Ser1108) H, M, R 4E-BP1 3 3 (Thr37/46) H, M, R

Eve Technologies 17 SPECIES HUMAN

18All targets listed in alphabetical order Eve Technologies Eve Tech provides the greatest number of human bio-markers in the industry. Below is a list of currently available targets. Don’t see your target on the list? Contact us.

• 2,4-dienoyl-CoA reductase (DECR1) • Bet v 1 • 3BP2 (Tyr) • Bla g 1 • 6Ckine / CCL21 / Exodus-2 • Bla g 2 • ABL2 (Tyr) • Blk (Tyr389) • ACC1 (Ser79) • BMP 2 • Acetyl-CoA acyltransferase 2 (ACAA2) • BMP 4 • Active Caspase 3 • BMP-9 • Active Caspase 8 • BNP • Active Caspase 9 • BRAK / CXCL14 • ADAMTS13 / VWFCP • BTK (Tyr) • Adiponectin / Acrp30 • c-AbI (Tyr245) • Adipsin / Complement Factor D • c-AbI (Tyr412) • AFP (Alpha-Fetal Protein) • c-Jun (Ser63) • Aggrecan • c-Jun (Ser73) • Aggregated Aβ (β-amyloid) / Aggregated AB • c-Kit (pan Tyr) • Agouti-related protein (AgRP) • c-Met / HGFR (pan Tyr) • Akt (Ser473) • c-Myc • Akt / PKB (Ser473) • C-Peptide • Akt / PKB (Thr308) • C1q • AKT1 substrate 1 (Thr246) • C2 • Albumin (Alb) • C3b • ALDH4A1 • C4b • alpha-Fetoprotein • C5 • Alternaria (Mold) • C9 • Amylin (active) / IAPP • CA 125 / MUC16 • Amylin (total) / IAPP • CA 15-3 • Amyloid β40 / AB1-40 / Amyloid B40 • CA 19-9 • Amyloid β42 / AB1-42 / Amyloid B42 • Calbindin • Angiogenin • CAM kinase 1α (ThrT177) • Angiopoietin-1 • CAMKKα (Thr108) • Angiopoietin-2 / ANGPT2 • Can f 1 • Angiostatin / Kringle • Cat Dander • Angiotensinogen (AGT) • Catalase • ANGPTL3 / ANGPT5 • Cathepsin D / CTSD • ANGPTL4 / ANGPTL2 / ARP • CCL28 • ANGPTL6 / AGF • CCP • Antithrombin III / Serpin C1 • CD 14 • Apelin • CD 163 • Apo AI • CD 27 • Apo AII • CD 30 • Apo B • CD 40 • Apo CII • CD3ε (pan Tyr) • Apo CIII • CD40L / CD154 • Apo E • CEA (Carcinoembryonic antigen) • APP • Centromere Protein B • April / TNFSF13 • Ceruloplasmin (CP) • ASCA • CES1 • Asp f 1 • Chemerin • ATF2 (Thr71) • Chromatin • AXL (Tyr772) • CK-MB (Creatinine Kinase) • AXL (Tyr859) • Cleaved PARP • B7-H1 / PD-L1 • Clusterin / CP-40 • BAD (Ser112) • CNTF (Ciliary neurotrophic factor) • BAFF / Blys / CD257 • Coagulation factor XIII • BCA-1 / BLC / CXCL13 • Collagen IV • Bcl-2 (Ser 70) • Complement C3 • BCMA • Complement C4 • Bcr-AbI (Tyr245) • Complement Component C5a • BDNF (plasma not recommended) • Complement Factor B • Bermuda Grass • Complement Factor H (CFH)

Eve Technologies 19 • Complement Factor I • Eotaxin / CCL11 / Eotaxin-1 • Complex I (NADH-Ubiquinone Oxidoreductase) • Eotaxin-2 / CCL24 • Complex II (Succinate Ubiquinone • Eotaxin-3 / CCL26 / MIP-4alpha Oxidoreductase) • EpCam • Complex III (Ubiquinone Cytochrome C • EPHX1 Oxidoreductase) • EPO (Erythropoietin) • Complex IV (Cytochrome C Oxidase) • ErbB2/Her2 (pan Tyr) • Complex V (ATP Synthase) • ErbB3 (pan Tyr) • Contactin-1 • ErbB4 (pan Tyr) • Cortisol (hydrocortisone) • Erk/MAPK 1/2 (Thr185/Tyr187) • CPT2 • ERK1 (Thr202/Tyr204) • CREB (Ser133) • ERK2 (Thr185/Tyr187) • Cripto-1 • Estradiol • CRK (Tyr) • ETF • CRKL (Tyr) • Extracellular matrix protein 1 (ECM1) • CRP (C-Reactive Protein) • FABP1 / L-FABP / FABPL • CSK (Tyr) • FABP3 / FABP11 • CTACK / CCL27 / SCYA27 • FABP4 / A-FABP • CXCL16 / SCYB16 • Factor V *Coming soon • CXCL6 / GCP-2 • Factor VII *Coming soon • CYFRA21-1 / Cytokeratin 19 Fragment • Factor VIII *Coming soon • CYP1A2 • Factor X *Coming soon • CYP2B6 • FAK (Tyr397) • CYP3A4 • Fas / APO-1 / CD95 • Cystatin C • FAS Ligand / CD95L • D-Dimer *not measured in Plasma • Fel d 1 (Cat allergen) • DAPP1 (Tyr) • Ferritin • DcR3 • Fetuin A / FETU-A • Der f 1 • FGF-1 / FGF-alpha / HBGF-1 • Der f 2 • FGF-13 • Der p 1 • FGF-19 • Der p 2 • FGF-2 (basic) • DGP • FGF-21 • DKK1 (Dickkopf-related protein 1) • FGF-23 • dPAPP-A / PAPP-A • Fgr (Tyr412) • DPPIV / CD26 • Fibrinogen / FGA • DR3 • Fibroblast activation Protein (FAP) / FAPA • DR5 / TNFRSF10B • Fibronectin / FN1 • ds-DNA • FLRG • E-cadherin • Flt-3 ligand / CD137 ligand • E-selectin / LECAM2 • Flt3 (pan Tyr) • EGF (Epidermal Growth Factor) / URG • Follistatin (FST) • EGFR (Ser1047) • Follistatin-like Protein 1 (FSTL1) • EGFR (Thr654) • Fractalkine / CX3CL1 • EGFR (Thr669) • Fractalkine High Sensitivity • EGFR (Tyr1045) • FSH (Follicle stimulating hormone) • EGFR (Tyr1068) • Fyn (pan Tyr) • EGFR (Tyr1086) • Fyn (Tyr) • EGFR (Tyr845) • FYN (Tyr420) • EGFR / HER1 • G-CSF / CSF3 • EGFR Total • G6PI • Egg White • Galectin 3 • EMMPRIN / CD147 • GAPDH • ENA-78 / CXCL5 • GBM • Endocan-1 (ESM-1) • GCP2 / CXCL6 • Endoglin • GDF-15 / PDF • Endostatin • GDNF • Endothelin-1 • GFAP (Glial Fibrillary Acidic Protein • ENO1 • GH (Growth Hormone) / hGH • ENPP-2 / Autotaxin • Ghrelin (active)

20 Eve Technologies • GIP (total) (Gastric inhibitory polypeptide) • IFN-β / IFN-beta • Gliadin A • IFNg High Sensitivity • Gliadin G • IFNω / IFN-omega 1 • GLP-1 (active) / Glucagon like peptide 1 • IgA • Glucagon / GCG • IgE (Total) Immunoglobulin E • Glycogen Synthase-1 (Ser641/Ser645) GS-1 • IGF-1 (single-plex) • GM-CSF / CSF2 • IGF1R (pan Tyr) • GM-CSF High Sensitivity • IGF1R (Tyr1131) • Granzyme B / Granzyme 2 • IGF1R (Tyr1135/1136) • GRAP (Tyr) • IGFBP1 • GRB10 (Tyr) • IGFBP2 • GRB14 (Tyr) • IGFBP3 • GRB2 (Tyr) • IGFBP4 • GRO / CINC-1 / KC / CXCL 1 • IGFBP5 • GSK-3α (Ser21) / GSK-3a • IGFBP6 • GSK-3α/β (Ser21/Ser9) / GSK-3a/b • IGFBP7 • GSK-3β (Ser9) / GSK-3b • IgG1 • GSTp / GSTπ • IgG2 • GSTα / GSTa • IgG3 • h-tTG • IgG4 • Haptoglobin / HP • IgM • HB-EGF • IkBα (Ser32/Ser36) / IkBa • HCC-1 / CCL14 • IL-1 RI • HCC-4 / CCL16 • IL-1 RII • HCGβ / HCGB • IL-10 / CSIF • Hck (pan Tyr411) • IL-10 High Sensitivity • HE4 (Human epididymis protein 4) • IL-11 / AGIF • Hemopexin (HX) • IL-12 (p40) • HER2 / ErbB2 • IL-12 (p70) • HGF (Hepatocyte Growth Factor) • IL-12 (p70) High Sensitivity • HIF-1a / HIF-1α • IL-13 • Histone • IL-13 High Sensitivity • Histone H1 • IL-14 / a-Taxilin • Histone H2A • IL-15 • Histone H2A.X (Ser139) • IL-16 / LCF • Histone H2B • IL-17 / IL-17A • Histone H3 (Ser10) • IL-17A High Sensitivity • Histone H4 • IL-17E / IL-25 • HLA Class 2 Single Ag Ab • IL-17F / ML-1 • HLA Class I and II • IL-18 / IL-1γ • HLA Class I Single Ag Ab • IL-18 BPa • HMGB1 • IL-19 • HSP-27 (Ser78) • IL-1b High Sensitivity • HSP-27 pS82 • IL-1ra / IL-1rα • HSP-27 Total • IL-1α / IL-1a • HSP-32 • IL-1β / IL-1b • HSP-60 • IL-2 / TCGF • HSP-65 • IL-2 High Sensitivity • HSP-70 (70 kilodalton heat shock proteins) • IL-20 / IL10D • HSP-71 • IL-21 • HSP-90 b • IL-21 High Sensitivity • HSP-90 α / HSP-90 a • IL-22 • Human Serum Albumin (HSA) • IL-23 / IL23 (p19) / IL-23A • I-309 / CCL1 • IL-23 High Sensitivity • I-TAC / CXCL11 / IP-9 • IL-24 • ICAM-1 / CD-54 • IL-25 / IL-17E • IFN-gamma R1 / IFNy R1 • IL-27 / IL27p28 / IL30 • IFN-y / IFN-g / IFNgamma • IL-28A / IFN lambda-2 • IFN-α / IFN-a • IL-28B / IFN lambda-3 • IFN-α2 / IFN-a2 • IL-29 / IFN lambda-1

Eve Technologies 21 • IL-2Rα / CD25 / IL2R • MAO-B • IL-3 / MCGF • MATK (Tyr) • IL-31 • MCAD • IL-32a • MCP-1 / CCL2 • IL-33 / NF-HEV (mature) • MCP-2 / CCL8 • IL-34 • MCP-3 / CCL7 • IL-35 • MCP-4 / CCL13 • IL-36 / IL-1F8 • MDC (macrophage-derived chemokine) / CCL22 • IL-37 / IL-1F7 • MEK1 (Ser217/Ser221) • IL-38 / IL-1F10 • MEK1 (Ser222) • IL-4 / BCGF-1 • MEK2 (Serr222/Ser226) • IL-4 High Sensitivity • Melanoma inhibitory activity (MIA) / CD-RAP • IL-5 • Melatonin • IL-5 High Sensitivity • MFG-E8 • IL-6 / HSF • MICA • IL-6 High Sensitivity • MICB • IL-6R (soluble) / CD126 • MIF • IL-7 • MIG / CXCL9 • IL-7 High Sensitivity • Milk • IL-8 / CXCL8 • MIP-1α / MIP-1a High Sensitivity • IL-8 High Sensitivity • MIP-1α / CCL3 / MIP-1a • IL-9 / HP40 • MIP-1β / CCL4 / MIP-1B • Insulin / INS • MIP-1β / MIP-1b High Sensitivity • Involucrin / IVL • MIP-1δ / MIP-5 / CCL15 • IP-10 / CXCL10 • MIP-3α / CCL20 / MIP-3a • IR (pan Tyr) • MIP-3α / CCL20 / MIP-3a High Sensitivity • IR (Tyr1162/Tyr1163) • MIP-3β / CCL19 / MIP-3b • IR-β (Tyr1146) / IR-B (Tyr1146) • MIP-4 / CCL18 / PARC • Irisin • Mite Pternoyssinus • IRS-1 (Ser312) • Mitochondrial trifunctional protein (TFP) • IRS-1 (Ser636/Ser639) • MMP-1 • IRS1 (Tyr) • MMP-10 • ITAC High Sensitivity • MMP-12 • IκBα (Thr291) (Ser32) / IkBa • MMP-13 • JNK/SAPK1 (Thr183/Tyr185) • MMP-2 • Jo-1 • MMP-3 • Kallikrein 6 • MMP-7 • Keratin-1, 10 / K10 • MMP-8 • Keratin-6 / KRT6A • MMP-9 • KIM-1 / HAVCR1 / TIM-1 • Mountain Cedar • KLF4 • MPIF / CCL23 • Lactotransferrin (LTF) / Lactoferrin • MPO (Myeloperoxidase) • LAT (pan Tyr) • MSK1 (Ser212) • Lck (Tyr394) • mTOR (Ser2448) • LCP2 (Tyr) • Mus m 1 • LDHA • Myoglobin • LDHB • Myostatin/GDF8 • Leptin / OB • NAGLU • LH (Luteinizing hormone) / lutropin • Nanog • LIF (Leukemia inhibitory factor) • NAP-2 / CXCL7 • LIGHT / TNFSF14 • Nephrin • LIN-28 • Neurotensin (NTS) • Lipocalin-1 • Neutrophil Elastase-2 (ELA2) • Lipocalin-2 / NGAL • NF-kB (Ser536) • LIX • NF-kB p65 (Ser536) • LPS (Lipopolysaccharides) • NGF / Beta-NGF / NGFβ • Lymphotactin / XCL1 • NNT • Lyn (pan Tyr397) • NRG1 beta 1 • M-CSF / CSF-1 • NSE (Neuron-Specific Enolase) / ENO2 • M-CSFR (pan Tyr) • NSP1 (Tyr) • Mannose-binding lectin / MBL • NT-Pro-ANP • MAO-A • NT-proBNP

22 Eve Technologies • Oct 3/4 • Prealbumin / PALB / TTR Transthyretin • Olfactomedin-4 (OLFM-4) • Procalcitonin • Omentin-1 • Progesterone / P4 • OPG (Osteoprotegerin) / TNFRSF11B • Progranulin • Orexin A • Proinsulin • OSM / Oncostatin M • Prolactin (PRL) / luteotropic hormone (LTH) • Osteoactivin • Protein C / Factor XIV • Osteocalcin (OC) • Protein S • Osteocrin/Musclin • Proteinase-3 (PRTN-3) • Osteonectin / SPARC / ON • PRX2 (PRDX2) • Osteopontin (OPN) / BSP-1 • PSA free / KLK3 • Oxytocin (Oxt) • PSA Total / KLK3 • P-Selectin / LECAM-3 • PTEN (Ser380) • p21 (CDKN1A) • PTH (Parathyroid hormone) • p38 (SAPK2A/B) (Thr180/Tyr182) • PTPN11-D2 (Tyr) • p38 (Thr180/Tyr182) • PTPN6-D2 (Tyr) • p38 MAPK (Thr180/Tyr182) • PYY (total) / Pancreatic Peptide • p53 (Ser15) • RANKL / TNFSF11 • p53 (Ser37) • RANTES / CCL5 • p53 (Ser46) • Rat n 1 • P55G-D1 (Tyr) • RBP4 • p70 S6 Kinase (Thr412) • Renin • p70 S6 kinase (Thr421/Ser424) • Resistin / ADSF • P85A-D1 (Tyr) • Retinoblastoma (Rb) (Ser249/Thr252) • P85A-D2 (Tyr) • Retinoblastoma (Rb) (Thr821) • P85B-D1 (Tyr) • RF • P85B-D2 (Tyr) • Ribosomal P • p90RSK (Thr359/Ser363) • RNP • PAI-1 (total)/Serpin E1 / tPAI-1 • RNP-A • Pancreatic Polypeptide (PP) • RNP-C • PARC / CCL18 • Ro 52/SSA 52 • PARK5/UCHL1 • ROBO4 • PARK7/DJ1 • RPS6 (Ser235/236) • PCNA • S100B (S100 calcium binding protein B) • PCSK9 • S6 ribosomal protein (Ser235/Ser236) • PDGF receptor-β (Tyr751, general) / PDGFRb • sAXL • PDGF-AA • sCD30 • PDGF-AB/BB • sCD40L / sTNFSF5 • PDGF-BB • SCF (Stem Cell Factor) / MGF • PDGFRα (pan Tyr & Total) / PDGFRa • SCFR (sStem Cell Factor Receptor) / sc-Kit • PDGFRβ (pan Tyr & Total) / PDGFRb • SCGF-β / CLEC11A / SCGF-b • PDH (Ser232) • SCHAD • PDH (Ser293) • Scl-70 • PDH (Ser300) • SDF-1α+β / CXCL12 / SDF-1a+b • PDH Total • sE-Selectin • PECAM-1 (soluble) / sCD31 / sPECAM-1 • sEGFR / sHER1 / • PEDF ( Pigment epithelium-derived factor) • Serum Amyloid A (SAA) • Pentraxin-3 (PTX3) • Serum Amyloid P / SAP / Pentraxin 2 • Perforin • Sex hormone binding globulin (SHBG) / SSBG • Periostin / OSF-2 • sFas • Peroxisomal bifunctional enzyme (LPBE/ECHD) • sFas-Ligand / CD95L / TNFRSF6 • Peroxisomal multifunctional enzyme 2 (MFE2) • sgp130 • Phl p 5 • SHC1 (Tyr) • Phospho Hsp27 (Ser78/82) • sHER2 / sEGFR2 • PKM 2 • sHGFR / sc-MET • PLGF (placental growth factor) / PLGF-2 • Short Ragweed • PMScl • sICAM-1 / CD54 • PON-1 • sIL-1RI • PRA Class I • sIL-1RII • PRA Class I and II • sIL-2Rα / sIL-2Ra • PRA Class II • sIL-4R • PRAS40(Thr246) • sIL-6R

Eve Technologies 23 • sIL-6Ra / sIL-6Rα • Tau (total) • sL-Selectin • Tenascin C (TN-C) • sLeptin R • TFF-3 (Trefoil factor 3) • SLPI • TFPI • Sm/Smith • TG • SmRNP • TGF-α / TGF-a • sNCAM • TGFß1 / TGFb1 • sNeuropilin-1 (sNRP-1) • TGFß2 / TGFb2 • SOCS2 (Tyr) • TGFß3 / TGFb3 • SOD1 • Thrombomodulin / CD141 • SOD2 • Thrombospondin-1 (TSP-1) / THBS1 • SOST (Sclerostin) • Thrombospondin-2 (TSP-2) • Sox2 • Tie1 (pan Tyr) • sP-selectin • Tie2 (pan Tyr) • sRAGE • Timothy Grass • Src (Tyr416) • TIMP-1 • Src (Tyr419) • TIMP-2 • SSA • TIMP-3 • SSA 60 • TIMP-4 • SSB/La • Tissue Factor (TF) / factor III • SSEA1 • Tissue plasminogen activator / tPA • SSO Class I HLA-A • TKT • SSO Class I HLA-B • TNF-R1 / CD120a / TNFRSF1A • SSO Class I HLA-C • TNF-R2 / TNFRSF1AB • SSO Class II DPB • TNFRI • SSO Class II DQA • TNFRII • SSO Class II DQB1 • TNFα / TNFa • SSO Class II DRB1 • TNFα / TNFa High Sensitivity • SSO Class II DRB3,4,5 • TNFβ / TNFb / LTA • SSO Cytokine SNPs • Total Cathepsin S • SSO KIR Human • TPO (Thrombopoietin) • ST2 • TRA-1-60 • STAP2 (Tyr) • TRA-1-81 • STAT 2 (Tyr689) • TRAIL / TNFSF10 • STAT1 (Tyr701) • Transferrin • STAT3 (Ser727) • Transglutaminase 2 • STAT3 (Tyr705) • Transglutaminase G • STAT5A/B (Tyr694/Tyr699) • TRAP • STAT6 (Tyr641) • TrkA (Tyr490) • sTIE-2 • Troponin I (Tnl) • sTNF-RI • Troponin T (TnT) • sTNF-RII • TRX1 • Streptolysin O • TSC2 (Ser939) • Substance P / TAC1 • TSH (Thyroid-stimulating hormone, thyrotropin) • (sample extraction required prior to sending • TSLP (Thymic stromal lymphopoietin) samples) • TWEAK • suPAR • Tyk2 (Tyr1054/Tyr1055) • sVCAM-1 / CD106 • ULBP-1 • sVEGF R2 • ULBP-2/5/6 • sVEGF R3 • ULBP-3 • sVEGF RI • ULBP-4 • sVEGFR-1 • uPA • sVEGFR-2 • Uromodulin • sVEGFR-3 • Uteroglobin • Syk (pan Tyr) • VAP-1 • SYK-D2 (Tyr) • Vaspin / Serpin A12 • T3 • VAV3 (Tyr) • T4 • VCAM-1 / CD106 • TACI • VEGF / VEGF-A • TARC / CCL17 • VEGF R1 (pan Tyr) • Tau (Ser199) • VEGF R2 (pan Tyr) • Tau (Thr181) • VEGF R3 (pan Tyr) • Tau (Thr231) / MAPT • VEGF-C

24 Eve Technologies • VEGF-D • α-1-Microglobulin / a-1-Microgloblin • Visfatin/PBEF • α-2 macroglobulin (α2-M) / A2M • Vitamin D Binding Protein / Gc-globulin • α-MSH (melanocyte-stimulating hormones) • Vitronectin / VTN • α-Synuclein /NAC / a-synuclein • von Willebrand Factor / VWF / FBVWF / VWD • α-Synuclein Aggregated / a-Synuclein Aggregated • Wheat (food) • α1-Antitrypsin / A1AT / AAT • Yes (Tyr421) • β-2-Microglobulin (B2M) / B-2-Microglobulin • YKL40 / CHI3L1 • β-Endorphin / B-Endorphin • ZAP-70 (pan Tyr) • α-1 acid glycoprotein (AGP) / Orosomucoid (ORM)

SPECIES RAT

All targets listed in alphabetical order

• 5’NT / CD73 • FABP3 / FABP11 • Adiponectin / Acrp30 • FGF-2 (basic) • Albumin (Alb) • Follistatin-like Protein 1 (FSTL1) • Amylin (active) / IAPP • Fractalkine / CX3CL1 • ARG1 • FSH (Follicle stimulating hormone) • BDNF (plasma not recommended) • G-CSF / CSF3 • C-Peptide 2 • GH (Growth Hormone) / hGH • Calbindin • Ghrelin (active) • Cardiac Troponin I / cTnl • GIP (total) (Gastric inhibitory polypeptide) • Cardiac Troponin T / cTnT • GLP-1 (active) / Glucagon like peptide 1 • Caveolin-1 • Glucagon / GCG • CINC-2 α/β / CXCL3 • GM-CSF / CSF2 • Clusterin / CP-40 • GOT1 • Complex I (NADH-Ubiquinone Oxidoreductase) • GRO / CINC-1 / KC / CXCL 1 • Complex III (Ubiquinone Cytochrome C • GSTp / GSTπ Oxidoreductase) • GSTα / GSTa • Complex V (ATP Synthase) • ICAM-1 / CD-54 • Connective Tissue Growth Factor (CTGF) • IFN-y / IFN-g / IFNgamma • Corticosterone • IgA • Creatinase Kinase Muscle / CKM • IgE (Total) Immunoglobulin E • CRP (C-Reactive Protein) • IgG1 • Cystatin C • IgG2a • DKK1 (Dickkopf-related protein 1) • IgG2b • EGF (Epidermal Growth Factor) / URG • IgG2c • Eotaxin / CCL11 / Eotaxin-1 • IgM • EPO (Erythropoietin) • IL-10 / CSIF

Eve Technologies 25 • IL-12 (p40) • PAI-1 (active) • IL-12 (p70) • PAI-1 (total)/Serpin E1 / tPAI-1 • IL-13 • Pancreatic Polypeptide (PP) • IL-17 / IL-17A • Prolactin (PRL) / luteotropic hormone (LTH) • IL-18 / IL-1γ • PTH (Parathyroid hormone) • IL-1α / IL-1a • PYY (total) / Pancreatic Peptide • IL-1β / IL-1b • RANKL / TNFSF11 • IL-2 / TCGF • RANTES / CCL5 • IL-4 / BCGF-1 • RBP4 • IL-5 • sE-Selectin • IL-6 / HSF • SHD • IL-7 • sICAM-1 / CD54 • Insulin / INS • SOST (Sclerostin) • IP-10 / CXCL10 • Substance P / TAC1 • KIM-1 / HAVCR1 / TIM-1 • (sample extraction required prior to sending • L-Selectin / CD62L samples) • Leptin / OB • sVCAM-1 / CD106 • LH (Luteinizing hormone) / lutropin • TFF-3 (Trefoil factor 3) • Lipocalin-2 / NGAL • TGFß1 / TGFb1 • LIX • TGFß2 / TGFb2 • M-CSF / CSF-1 • TGFß3 / TGFb3 • MCP-1 / CCL2 • TIMP-1 • MCP-3 / CCL7 • TNFα / TNFa • Melatonin • TSH • MIP-1α / CCL3 / MIP-1a • (Thyroid-stimulating hormone, thyrotropin) • MIP-2 / CXCL2 • VEGF / VEGF-A • MIP-3α / CCL20 / MIP-3a • von Willebrand Factor / VWF / FBVWF / VWD • Myosin Light Chain 3 / MYL3 • α-1 acid glycoprotein (AGP) / Orosomucoid (ORM) • Neurotensin (NTS) • α-1-Microglobulin / a-1-Microgloblin • OPG (Osteoprotegerin) / TNFRSF11B • α-MSH (melanocyte-stimulating hormones) • Orexin A • β-2-Microglobulin (B2M) / B-2-Microglobulin • Osteoactivin • β-Endorphin / B-Endorphin • Osteocalcin (OC) • Osteopontin (OPN) / BSP-1 • Oxytocin (Oxt)

26 Eve Technologies SPECIES MOUSE

All targets listed in alphabetical order

• 6Ckine / CCL21 / Exodus-2 • HGF (Hepatocyte Growth Factor) • Adiponectin / Acrp30 • IFN-y / IFN-g / IFNgamma • Adipsin / Complement Factor D • IFN-α / IFN-a • Amphiregulin • IFN-β / IFN-beta • Amylin (active) / IAPP • IgA • Angiopoietin-2 / ANGPT2 • IgE (Total) Immunoglobulin E • BDNF (plasma not recommended) • IGFBP1 • Betacellulin / BTC • IGFBP2 • C-Peptide 2 • IGFBP3 • CD40L / CD154 • IGFBP5 • CD93 / C1q R1 • IGFBP6 • Clusterin / CP-40 • IGFBP7 • Complex I (NADH-Ubiquinone Oxidoreductase) • IgG1 • Complex III (Ubiquinone Cytochrome C • IgG2a Oxidoreductase) • IgG2b • Complex V (ATP Synthase) • IgG3 • CRP (C-Reactive Protein) • IgM • Cystatin C • IL-10 / CSIF • DKK1 (Dickkopf-related protein 1) • IL-12 (p40) • EGF (Epidermal Growth Factor) / URG • IL-12 (p70) • EMMPRIN / CD147 • IL-13 • Endoglin • IL-15 • Endothelin-1 • IL-16 / LCF • Eotaxin / CCL11 / Eotaxin-1 • IL-17 / IL-17A • EPO (Erythropoietin) • IL-17E / IL-25 • FGF-2 (basic) • IL-17F / ML-1 • Follistatin (FST) • IL-18 / IL-1γ • Fractalkine / CX3CL1 • IL-1α / IL-1a • FSH (Follicle stimulating hormone) • IL-1β / IL-1b • G-CSF / CSF3 • IL-2 / TCGF • GH (Growth Hormone) / hGH • IL-20 / IL10D • Ghrelin (active) • IL-21 • GIP (total) (Gastric inhibitory polypeptide) • IL-22 • GLP-1 (active) / Glucagon like peptide 1 • IL-23 / IL23 (p19) / IL-23A • Glucagon / GCG • IL-25 / IL-17E • GM-CSF / CSF2 • IL-27 / IL27p28 / IL30 • GRO / CINC-1 / KC / CXCL 1 • IL-28B / IFN lambda-3 • Haptoglobin / HP • IL-3 / MCGF

Eve Technologies 27 • IL-31 • Resistin / ADSF • IL-33 / NF-HEV (mature) • RNP • IL-4 / BCGF-1 • S100A8 • IL-5 • S100A9 • IL-6 / HSF • sALK-1 • IL-7 • sCD30 • IL-9 / HP40 • SDF-1 / CXCL12 • Insulin / INS • sE-Selectin • IP-10 / CXCL10 • Serum Amyloid A-3 (SAA-3) • KIM-1 / HAVCR1 / TIM-1 • Serum Amyloid P / SAP / Pentraxin 2 • Leptin / OB • sFas • LH (Luteinizing hormone) / lutropin • sFas-Ligand / CD95L / TNFRSF6 • LIF (Leukemia inhibitory factor) • sgp130 • Lipocalin-2 / NGAL • sICAM-1 / CD54 • LIX • sIL-1RI • M-CSF / CSF-1 • sIL-1RII • MCP-1 / CCL2 • sIL-2Rα / sIL-2Ra • MCP-3 / CCL7 • sIL-4R • MCP-5 / CCL12 • sIL-6R • MDC (macrophage-derived chemokine) / CCL22 • SOST (Sclerostin) • MIG / CXCL9 • sP-selectin • MIP-1α / CCL3 / MIP-1a • sRAGE • MIP-1β / CCL4 / MIP-1B • sTNF-RI • MIP-2 / CXCL2 • sTNF-RII • MIP-3α / CCL20 / MIP-3a • Substance P / TAC1 • MIP-3β / CCL19 / MIP-3b • (sample extraction required prior to sending • MMP-12 samples) • MMP-2 • sVEGF R2 • MMP-3 • sVEGF R3 • MMP-8 • sVEGF RI • Neurotensin (NTS) • TARC / CCL17 • OPG (Osteoprotegerin) / TNFRSF11B • TGFß1 / TGFb1 • Orexin A • TGFß2 / TGFb2 • Osteocalcin (OC) • TGFß3 / TGFb3 • Osteopontin (OPN) / BSP-1 • Thrombomodulin / CD141 • Oxytocin (Oxt) • Thrombospondin-4 • PAI-1 (total)/Serpin E1 / tPAI-1 • TIMP-1 • Pancreatic Polypeptide (PP) • TNFα / TNFa • PCSK9 • Troponin I (Tnl) • PECAM-1 (soluble) / sCD31 / sPECAM-1 • Troponin T (TnT) • Pentraxin-3 (PTX3) • TSH • Periostin / OSF-2 • (Thyroid-stimulating hormone, thyrotropin) • PLGF (placental growth factor) / PLGF-2 • VEGF / VEGF-A • PR3 (cANCA) • VEGF-C • pro MMP-9 • VEGF-D • Prolactin (PRL) / luteotropic hormone (LTH) • α-1 acid glycoprotein (AGP) / Orosomucoid (ORM) • PYY (total) / Pancreatic Peptide • α-2 macroglobulin (α2-M) / A2M • RANKL / TNFSF11 • α-MSH (melanocyte-stimulating hormones) • RANTES / CCL5 • β-2-Microglobulin (B2M) / B-2-Microglobulin • Renin • β-Endorphin / B-Endorphin

28 Eve Technologies SPECIES PRIMATE

AllEve targets Technologies listed in alphabetical order 29 • ACTH • IL-31 • Adiponectin / Acrp30 • IL-33 / NF-HEV (mature) • Agouti-related protein (AgRP) • IL-4 / BCGF-1 • Amylin (active) / IAPP • IL-5 • BCA-1 / BLC / CXCL13 • IL-6 / HSF • BDNF (plasma not recommended) • IL-8 / CXCL8 • C-Peptide • Insulin / INS • CD40L / CD154 • IP-10 / CXCL10 • CNTF (Ciliary neurotrophic factor) • Leptin / OB • Eotaxin / CCL11 / Eotaxin-1 • LH (Luteinizing hormone) / lutropin • FGF-2 (basic) • MCP-1 / CCL2 • Fractalkine / CX3CL1 • MCP-3 / CCL7 • FSH (Follicle stimulating hormone) • MIF • G-CSF / CSF3 • MIG / CXCL9 • GH (Growth Hormone) / hGH • MIP-1α / CCL3 / MIP-1a • Ghrelin (active) • MIP-1β / CCL4 / MIP-1B • GIP (total) (Gastric inhibitory polypeptide) • MIP-3α / CCL20 / MIP-3a • GLP-1 (active) / Glucagon like peptide 1 • NGF / Beta-NGF / NGFβ • Glucagon / GCG • PAI-1 (total)/Serpin E1 / tPAI-1 • GM-CSF / CSF2 • Pancreatic Polypeptide (PP) • Granzyme A • PDGF-BB • Granzyme B / Granzyme 2 • Perforin • I-TAC / CXCL11 / IP-9 • Prolactin (PRL) / luteotropic hormone (LTH) • IFN-y / IFN-g / IFNgamma • PYY (total) / Pancreatic Peptide • IFN-α / IFN-a • RANTES / CCL5 • IL-10 / CSIF • Resistin / ADSF • IL-12 (p70) • sCD137 • IL-12 / IL23 (p40) • sCD40L / sTNFSF5 • IL-13 • SCF (Stem Cell Factor) / MGF • IL-15 • sFas-Ligand / CD95L / TNFRSF6 • IL-16 / LCF • sICAM-1 / CD54 • IL-17 / IL-17A • sVCAM-1 / CD106 • IL-17E / IL-25 • TGF-α / TGF-a • IL-17F / ML-1 • TGFß1 / TGFb1 • IL-18 / IL-1γ • TGFß2 / TGFb2 • IL-1ra / IL-1rα • TGFß3 / TGFb3 • IL-1α / IL-1a • TNFα / TNFa • IL-1β / IL-1b • TNFβ / TNFb / LTA • IL-2 / TCGF • TRAIL / TNFSF10 • IL-21 • TSH (Thyroid-stimulating hormone, thyrotropin) • IL-22 • VEGF / VEGF-A • IL-23 / IL23 (p19) / IL-23A • VEGF-D • IL-28A / IFN lambda-2

30 Eve Technologies SPECIES FELINE

All targets listed in alphabetical order

• Flt-3 ligand / CD137 ligand • MCP-1 / CCL2 • GM-CSF / CSF2 • PDGF-BB • GRO / CINC-1 / KC / CXCL 1 • RANTES / CCL5 • IFN-y / IFN-g / IFNgamma • SCF (Stem Cell Factor) / MGF • IL-12 (p40) • SDF-1 / CXCL12 • IL-1β / IL-1b • sFas • IL-2 / TCGF • TGFß1 / TGFb1 • IL-4 / BCGF-1 • TGFß2 / TGFb2 • IL-6 / HSF • TGFß3 / TGFb3 • IL-8 / CXCL8 • TNFα / TNFa

Eve Technologies 31 SPECIES PORCINE

All targets listed in alphabetical order

• GM-CSF / CSF2 • IL-2 / TCGF • IFN-y / IFN-g / IFNgamma • IL-4 / BCGF-1 • IFN-α / IFN-a • IL-6 / HSF • IL-10 / CSIF • IL-8 / CXCL8 • IL-12 / IL23 (p40) • TGFß1 / TGFb1 • IL-18 / IL-1γ • TGFß2 / TGFb2 • IL-1ra / IL-1rα • TGFß3 / TGFb3 • IL-1α / IL-1a • TNFα / TNFa • IL-1β / IL-1b

32 Eve Technologies SPECIES CANINE

All targets listed in alphabetical order

• ACTH • IL-7 • Albumin (Alb) • IL-8 / CXCL8 • Amylin (total) / IAPP • Insulin / INS • BDNF (plasma not recommended) • IP-10 / CXCL10 • Clusterin / CP-40 • KIM-1 / HAVCR1 / TIM-1 • Cortisol (hydrocortisone) • Leptin / OB • CRP (C-Reactive Protein) • LH (Luteinizing hormone) / lutropin • Estradiol • MCP-1 / CCL2 • FSH (Follicle stimulating hormone) • NGF / Beta-NGF / NGFβ • GH (Growth Hormone) / hGH • Pancreatic Polypeptide (PP) • Ghrelin (active) • Progesterone / P4 • GIP (total) (Gastric inhibitory polypeptide) • Prolactin (PRL) / luteotropic hormone (LTH) • GLP-1 (active) / Glucagon like peptide 1 • PYY (total) / Pancreatic Peptide • Glucagon / GCG • SCF (Stem Cell Factor) / MGF • GM-CSF / CSF2 • T3 • IFN-y / IFN-g / IFNgamma • T4 • IL-10 / CSIF • TGFß1 / TGFb1 • IL-12 / IL23 (p40) • TGFß2 / TGFb2 • IL-15 • TGFß3 / TGFb3 • IL-18 / IL-1γ • TNFα / TNFa • IL-2 / TCGF • TSH (Thyroid-stimulating hormone, thyrotropin) • IL-6 / HSF

Eve Technologies 33 Details

GSIN Code H3, AN11, BO GSIN Description Commercial Testing and Laboratory Services GSIN Category Services GSIN Group Description Quality Control, Testing, Inspection and Technical Representative Services GSIN Code Status Not applicable

GSIN direct descendent’s

H300 - Inspection and Testing Services Code AN11 - Biomedical B000 - Chemical or Biological Studies and Analysis

NAICS - 541711 - Biotechnology research and development laboratories or services in health sciences NAICS - 541711 - Biotechnology research and development laboratories or services in chemical sciences NAICS - 541711 - Biotechnology research and development laboratories or services in the medical sciences NAICS - 541380 - Assaying services NAICS -621511 - Testing laboratories, medical

CONTACT

Ship your Samples to Eve at the below address Eve’s laboratory is located at the below

Eve Technologies Corporation Eve Technologies Corporation Deliver Direct Deliver Direct HRIC 3A26 HRIC 3A26 3330 Hospital Dr., N. W. 3330 Hospital Dr., N. W. Calgary, AB. Canada T2N 4N1 Calgary, AB. Canada T2N 4N1

Mail & Web M: [email protected] W: www.evetechnologies.com

34 Eve Technologies