US 2005O181077A1 (19) (12) Patent Application Publication (10) Pub. No.: US 2005/0181077 A1 Asiedu et al. (43) Pub. Date: Aug. 18, 2005

(54) COMPOSITION TREATING FOR AIDS AND Publication Classification ASSOCATED CONDITIONS (51) Int. Cl." ...... A61K 35/78 (76) Inventors: William Asiedu, Accra (GH); (52) U.S. Cl...... 424/725; 424/769 Frederick Asiedu, Accra (GH); Manny Ennin, Accra (GH); Michael Nsiah (57) ABSTRACT Doudu, Accra (GH); Charles Antwi An Aids and associated conditions related to Aids treating Boateng. Accra (GH); Kwasi compositions is disclosed. The compositions comprise: a Appiah-Kubi, Accra (GH); Seth medicament Selected from an extract of at least one of the Opoku Ware, Accra (GH); Debrah following families: (PleioScarpa Bicar Boateng. Accra (GH); Kofi Ampim, pellata); Annonaceae (Cleistopholis Patens); Dichapetal Accra (GH); William Owusu, Accra aceae (Dichapetehan Madagasca Riense); Annoceae (GH); Akwete Lex Adjei, Bridgewater, (Uvaristrum Pierreanum); Cynocynaceae (Strophantus Gra NJ (US) tus); Asclepiadaceae (GongrOnema Latifolium); Combreta Correspondence Address: ceae (Combretum Racemosum), Apocynaceae (AloStonia BOOnei); Amaranthaceae (Altemanthera Pungens); Aroceae FROMMER LAWRENCE & HAUG (Anchomanes Differmis); (Seleria Voivinil); 745 FIFTHAVENUE- 10TH FL. (Lannea Acida); ( Afri NEW YORK, NY 10151 (US) cana); (Ceiba Pentanoia); Anarcardiaceae (21) Appl. No.: 10/902,993 ( Micraster); Bombacaceae (Bombax Bounopo zense): Anarcardiaceae (Spondias Mombin); Caricaceae (22) Filed: Jul. 30, 2004 (Carica Papaya); a glyceryl ester of any of the foregoing extracts, a Saponin of any of the foregoing extracts, an Related U.S. Application Data alkaloid of any of the foregoing extracts, a protein of any of the foregoing extracts, a fat of any of the foregoing extracts, (63) Continuation of application No. 10/241,973, filed on a Sugar of any of the foregoing extracts, and any mixture of Sep. 12, 2002, now abandoned. any of the foregoing. US 2005/0181.077 A1 Aug. 18, 2005

COMPOSITION TREATING FOR AIDS AND be reportable in some states and cities but will not be ASSOCATED CONDITIONS nationally reportable. Because perSons with less Specific or milder manifestations of HTLV-III(LAV infection may be BACKGROUND OF THE INVENTION important in transmitting the virus, estimates of the number of Such perSons are of value. These estimates can be 0001) 1. Field of the Invention obtained through epidemiologic Studies or special Surveys in 0002 This invention relates to a composition for treating Specific populations. AIDS and related conditions, and more particular, to a 0007 Issues related to the case definition of AIDS were composition comprising at least one extract of a Selected discussed by the Conference of State and Territorial Epide plant. miologists (CSTE) at its annual meeting in Madison, Wis., Jun. 2-5, 1985. The CSTE approved the following resolu 0003 2. Description of the Prior Art tions: 0004 Patients with illnesses that, in retrospect, were manifestations of acquired immunodeficiency Syndrome 0008 1. that the case definition of AIDS used for (AIDS) were first described in the summer of 1981 CDC national reporting continue to include only the more Pneumocystis pneumonia-Los Angeles. MMWR 1981, severe manifestations of HTLV-III/LAV infection; 30:250-2; CDC-Kaposi's Sarcoma and Pneumocystis and pneumonia among homosexual men-New York City and 0009 2. that the Center For Disease Control (CDC) California. MMWR 1981, 30:305-8). A case definition of develop more inclusive definitions and classifica AIDS for national reporting was first published in the tions of HTLV-III/LAV infection for diagnosis, treat MMWR in September 1982 CDC-Hepatitis B virus vac ment, and prevention, as well as for epidemiologic cine Safety. report of an inter-agency group MMWR 1982, Studies and Special Surveys, and 31:465-67; CDC-Update On acquired immune deficiency syndrome (AIDS)-United States. MMWR 1982, 31:507 0010) 3. that the following refinements be adopted in 14. Since then the definition has undergone minor revisions the case definition of AIDS used for national report in the list of diseases used as indicators of underlying ing: cellular immunodeficiency Jaffe HW, Bregman DJ, Selik 0.011 a. In the absence of the opportunistic dis R M. Acquired immune deficiency Syndrome in the United easeS required by the current case definition, any States: the first 1,000 cases. J Infect Dis 1983, 148:339-45; of the following diseases will be considered Jaffe H W, Selik R. M. Acquired immune deficiency Syn indicative of AIDS if the patient has a positive drome: is disseminated aspergillosis predictive of underly serologic or virologic test for HTLV-III/LAV: ing cellular immune deficiency?, (Reply to letter), J Infect Dis 1984, 149:829; Selik RM, Haverkos H W. Curran J W. 0012 1. disseminated histoplasmosis (not confined Acquired immune deficiency Syndrome (AIDS) trends in the to lungs or lymph nodes), diagnosed by culture, United States, 1978-1982. Am J Med 1984, 76:493-500; histology, or antigen detection; CDC, Update: acquired immunodeficiency Syndrome 0013 2. isosporiasis, causing chronic diarrhea (over (AIDS)–United States. MMWR 1984, 32:688-91) 1 month), diagnosed by histology or stool micros 0005 Since the 1982 definition was published, human copy; T-cell lymphotropic virus type III/lymphadenopathy-associ 0014) 3. bronchial or pulmonary candidiasis, diag ated virus (HTLV-III/LAV) has been recognized as the cause nosed by microScopy or by presence of characteristic of AIDS. The clinical manifestations of (HTLV-III/LAV) white plaques grossly on the bronchial mucosa (not infection may be directly attributable to infection with this Virus or the result of Secondary conditions occurring as a by culture alone); consequence of immune dysfunction caused by the under 0015 4. non-Hodgkins' lymphoma of high-grade lying infection with (HTLV-III/LAV). The range of mani pathologic type (diffuse, undifferentiated) and of festations may include none, nonspecific signs and Symp B-cell unknown immunologic phenotype, diagnosed toms of illness, autoimmune and neurologic disorders, a by biopsy; variety of opportunistic infections, and Several types of 0016 5. histologically confirmed Kaposi's sarcoma malignacy. AIDS was defined for national reporting before in patients who are 60 years old or older when its etiology was known and has encompassed only certain diagnosed. Secondary conditions that reliably reflected the presence of a Sever immune dysfunction. Current laboratory tests to 0017 b. In the absence of the opportunistic dis detect (HTLV-III/LAV) antibody make it possible to include easeS required by the current case definition, a additional Serious conditions in the Syndrome, as well as to histologically confirmed diagnosis of chronic lym further improve the specificity of the definition used for phoidinterstitial pneumonitis in a child (under 13 reporting cases. years of age) will be considered indicative of AIDS unless test(s) for HTLV-III/LAV are nega 0006. The current case definition of AIDS has provided tive. useful data on disease trends, because it is precise, consis tently interpreted, and highly specific. Other manifestations 0.018 c. Patients who have a lymphoreticular of HTLV-III/LAV infections than those currently proposed malignancy diagnosed more than 3 months after to be reported are leSS Specific and less likely to be consis the diagnosis of an opportunistic disease used as a tently reported nationally. Milder disease associated with marker for AIDS will no longer be excluded as HTLV-III/LAV infections and asymptomatic infections may AIDS cases. US 2005/0181.077 A1 Aug. 18, 2005

0019 d. To increase the specificity of the case phellodendron amureause, and Sepia aculeata. The medicine definition, patients will be excluded as AIDS cases is used in Such a manner that the powdered basis part is if they have a negative result on testing for Serum mixed and Stirred with tea water until it becomes plaster antibody to HTLV-III/LAV, have no other type of like, and the adjuvant part is Scattered in dry form onto the HTLV-III/LAV test with a positive result, and do wound or Swollen area caused by the black foot disease not have a low number of T-helper lymphocytes or before the plaster-like basis part is applied to the wound or a low ratio of T-helper to T-SuppreSSor lympho Swollen area about 0.5 cm in thickness. The wound is then cytes. In the absence of test results, patients Sat bandaged and the medicine is renewed once or twice a day isfying all other criteria in the definition will until fresh flesh appears in the wound. Thereafter, the continue to be included. CDC will immediately medicine is continuously applied but in a dry form until the adopt the above amendments to the case definition wound is completely healed. The extract medicament com of AIDS for national reporting. position taught by Chen et al., does not have any impact on AIDS itself as a systemic disease. 0020. This revision, in the case definition will result in the reclassification of less than 1% of cases previously SUMMARY OF THE INVENTION reported to CDC. The number of additional new cases reportable as a result of the revision is expected to be Small. 0023 The present invention is related to a composition Cases included under the revised definition will be distin for treating AIDS and associated conditions related to AIDS guishable from cases included under the old definition So as the composition comprises a medicament which is an extract to provide a consistent basis for interpretation of trends. of at least one plant family. CDC will also develop draft classifications for disease manifestations of HTLV-III/LAV infections other than DETAILED DESCRIPTION AIDS, distribute these widely for comment, and publish the 0024. The present invention relates to a novel extract results. Reported by Conference of State and Territorial medicament for use in treating AIDS, an immune deficiency Epidemiologists; AIDS Br., Div of Viral Diseases, Center for or immunologically compromised disease, as well as a Infectious Disease, CDC. variety of AIDS related ailments, including recurrent and 0021 Han et al. Disclosed a process for preparing an persistent fever, chronic diarrhea, dermatitis, generalized extracted Substance from, a mixture of a non-fat Starch from lymphodenpathy, persistent cough, general pain, tuberculo Ricini Semen and a root of Coptis Sp for therapeutic appli sis, and amenorrhea. The extract is prepared from the bark, cations of AIDS U.S. Pat. No. 5,928,645). The authors , root and stems of at least one plant from within the maintain that the extracted Substance was effective in treat apocynaceae, annonaceae, dichapetalaceae, annoceae, cyno ing AIDS but provided no clinical data as to the effect of this cynaceae, asclepiadaceae, combretaceae, amaranthaceae, Substance in AIDS patients. In continuing work, Han et al., araceae, cyperaceae, anacardiaceae, bignoniaceae, bom demonstrated Significant anti-oxidant capacity of their bacaceae, and caricacea plant families. Ricini Semen extract using a chemiluminescence assay 0025. A suitable plant is selected. Preferably a mixture of Hong, E. K., Kim, Y. K. Lee, W. C., Shin, H. K., and Kim, at least two is Selected. Suitable plants are Selected J. B.; Measurement of antioxidation activity based on from a family of plants including (1) apocynaceae, (2) chemiluminescence reaction. In Bioluminescence and annonaceae, (3) dichapetalaceae, (4) annoceae, (5) cynocyn Chemiluminescence (Status Report), Eds. Szalay, A. A., aceae, (6) asclepiadaceae, (7) combretaceae, (8) amaran Kiicka, L. J., and Stanley, P., John Wiley & Sons Ltd. thaceae, (9)araceae, (10) cyperaceae, (11) anacardiaceae, London, England, pp. 244-246, 1993). Antioxidant activity (12) bignoniaceae, (13) bombacaceae, (14) an arcardiaceae of Ricini Semen extract was compared with t-butylhydroxy and caricaceae plant families. toluene (BHT), a potent antioxidant known to people of ordinary skill in the field of the invention. The authors 0026. These plants are tropical herbs that grow naturally therefore proposed that Ricini Semen extract has anti-HIV and can be thus cultivated in tropical, Savanna, grassland or effect although no clinical data was presented.: Investiga lightly wooded forests of West . These desert plants tions of the Ricini Semen extract in laboratory animals by can also be found in other tropical regions of the World, Sub-cutaneous injection revealed significant tubular necro including Asia, Asia Minor, South America and possibly the sis, glomerulonephritis, and vacuolation in livers of male South-Western, Western and Plains regions of the United and female mice, interstitial nephritis being demonstrated as States. The active medicaments from these plants include, well in female mice. Rats showed similar symptoms in both but are not limited to glyceryl esters, Saponins and Several of the; male and female. Mitosis in the liver was typically derivatives of alkaloids, glycosides, proteins, fats, and Sug found, and extramedullary hematopoiesis in the liver and S. Spleen also were frequently observed. Other organs were not 0027. The plants perse are not employed as the requisite changed compared to controls U.S. Pat. No. 5,928,645). medicament, but rather the extract of Such Selected plant or 0022 Chen et al., U.S. Pat. No. 6,077,512 disclosed a plants. The extraction process for the medicaments from the novel topical treatment method for curing black foot disease respective plants comprises the following: using plant extracts. The extract medicament comprised a 0028 (a) harvesting the barks, stems, and basis part consisting of equal amounts of ground, powdered, roots of each plant, and cutting these into chipS and and mixed clove, frankincense, myrrha, fhizama arisaema tis, pinellia, monkShood (root) or kusneZoff monkShood chunks, (root), and tuber of bamboo-leaved orchid, and an adjuvant 0029 (b) washing and drying the chips and chunks part consisting of equal amounts of round, powdered, and under a controlled temperature condition, typically mixed borneol, powdered Soybean, borax, coptis root and/or about 15° to 68° C. for about 3 days; US 2005/0181.077 A1 Aug. 18, 2005

0030) (c) proportionally mixing the washed and 0035 (h) adding a conventional preservative sys dried materials from each plant to formulate a mix tem, e.g., creSols, parabens, p-chlormoetaXylenol, ture needed for each type of clinical application; benzoates, alcohols, to maintain antimicrobial pre 0031 (d) grinding the resultant mixture of plant Servative efficacy of the mixed plant extract; parts to a powder composition having a particle size 0036 (i) mixing the extracts in a suitable container, typically ranging in size from about 100 microns to and Subjecting the resulting elute repeatedly to fil about 10,000 microns; tration under appropriate pressure and temperature 0032 (e) extracting about one part of the resultant conditions, to yield a pure, clean, preserved plant powdery mixture in about two pails of purified water extract for human consumption; under slow percolation for about 1 to about 5 hours under a temperature in the range of about 760 to 0037 () fill the resultant extract through a stainless about 116 C. and allowing the mixture to cool in Steel Strainer into appropriate containers for distri appropriate containers under ambient temperature bution; and conditions, i.e., about 160 to about 33 C., for 0038 (k) labeling the containers and presenting approximately 1 to 2 days, these for Storage (The resultant concentrate may also 0033 (f) re-extracting the resultant mixture in a be further concentrated into powder under reduced Second percolation process using approximately 2 temperature/pressure conditions, e.g., by tray drying, parts of purified water under slow percolation for Solvent extraction, Solvent exclusion, or Spray dry about 1 to about 5 hours under a temperature in the ing, to result in a yellowish-brown amporphous, range of about 76 to about 116 C. and allowing the powder for use as an injectable or Solid product Such mixture to cool in appropriate containers under as a tablet, or by Subjecting the resultant product to ambient temperature conditions i.e., about 16 to a filtration through a membrane filter and then a about 33 C., for approximately 1 to 2 days; lypohilization to give powders, and then packaging the resulting mixed extracts in appropriate closure 0034 (g) repeating the extraction process a third Systems for clinical use. time using a double portion of purified water under slow percolation for about 1 to about 5 hours under 0039 Typically the resultant concentrated extract con a temperature in the range of about 76 to about 116 tains the following compounds for each plant concentrate C. and allowing the mixture to cool in appropriate obtained: see L. Watson and M. J. Dallwitz (1992) containers tinder ambient temperature conditions onwards). The Families of Flowering Plants: Descriptions, i.e., about 16 to about 33 C., for approximately 1 Illustrations, Identification, and Information Retrieval. Ver to 2 days, sion: 14 Dec. 2000:

TABLE I

PLANT COMPOUNDS (1) Apocynaceae : Subclass Dicotyledonae; Tenuinucelli. cyanogenics, alkaloids Dahlgren's Superorder Gentianiflorae. Species 1500. iridoids verbascosides, Genera 164: AcOkanthera, Adenium, Aganoneirion, proanthocyanidins, cyanidins AganoSna, Alafia, Allananda, Aliomarkgrafia, delphinidins, flavonols, Allowoodsonia, Alstonia, Alyxia, Annocalyx, Anbeiania, kaempferols, quercetins, AmSonia, Ancylobotrys, Anechites, Angadenia, Anodendron, elagic acid, ursolic acid, , Arduina, Artia, ASketanthera, Aspidosperna, Saponins/sapogenins, Baissea, Beaumontia, Bouisigonia, Cabucaia, Callichia, aluminum salts, sucrose, Calocrater, Cameraria, , Carpodinus, Carruthersia, oligosaccharides, and sugar , Catharanthus, Cerbera, Cerberiopsis, alcohols Chamaecilitandra, Chilocarpus, Chonemorpha, Cleghornia, Citandra, Condylocarpon, Couna, Craspidospernum, Crioceras, Cycladenia, Cyclocotyla, Cylindropsis, Delphyodon, Dewevrella, Dictyophleba, Dipladenia, Diplorhynchus, Dyera, Ecdysanthera, Echites, Elytropus, Epigynium, Eucorymbia, Farquharia, Fernaldia, Forsteronia, Funtunia, Galactophora, GeissOSpernum, Gonioma, Grisseea, Hancornia, Haplophyton, Himatanthus, Hollarrhena, Hunteria, Hymenolophus, Ichnocarpus, Sonena, Ixodonerium, Kanettia, Kibatalia, Kopsia, Lacneilea, Landolphia, Laubertia, Laxopiuneria, Lepinia, Lepiniopsis, Leuconotis, Lochnera, Lyonsia, MacOubea, Macropharynx, Macrosiphonia, Malouetia, Mandevilia, Mascarenhasia, Melodinus, Mesechites, Micrechtites, Microplumeria, Molongum, Mortoniella, Motandra, Mucoa, Neobracea, Neocouma, , Nouettea, Ochrosia, Odontadenia, Orthopichonia Oncinotis, Pachypodium, Pachouria, Papuechites, Parahancornia, Parameria, Parepigynum, , Peitastes, Pentalinon, Petchia, Picralina, Piectaneia, US 2005/0181.077 A1 Aug. 18, 2005

TABLE I-continued

PLANT COMPOUNDS Pleiocarpa, Pleioceras, Plumeria, Pottsia, Prestonia, Pycnobotrya, Quiotania, Rauwolfia, Rhabdadenia, Rhazya, Rhigospira, Rhodocalyx, Rhyncodia, Saba, Salpinctes, Schizozygia, Secondatia, Sindechites, Spongiosperma Skytanthus, Spirolobium, Stennadenia, StephanoStegia, StephanoStenna, Stipecona, Strenpeiopsis, Strophanthus, , Tabernanthe, Tennadenia, Thenardia, Thevetia, Tintinnabularia, Trachelospermum, Urceola, Urnularia, Vahadenia, Wallariopsis, Vallaris, Vallesia, Vinca, Voacanga, , Woytkowskia, Wrightia, Xylinabaria, Xylinabariopsis. (2) Annonaceae Taxonomy - Subclass Dicotyledonae; Crassinucelli. cyanogenics, alkaloids, Dahlgren's Superorder Magnoliiflorae; Annonales. iridoids, proanthocyanidins, Cronquist's Subclass Magnoliidae; Magnoliales. APG cyanidin, flavonols, (1998) basal order; Magnoliales. Species 1200. Genera 126; quercetins, elagic acid, Afroguatteria, AlphonSea, Ambavia, Anaxagorea, Ancana, sucrose, oligosaccharides Annickia, Annona, Anonianthus, Anonidium, Artabotrys, A.Simina, Asteranthe, Balonga, Bocagea, Bocageopsis, Boutiquea, Cananga, Cardiopetalun, Chieniodendron, Cleistochlamys, Cleistopholis, Cremastosperma, Cyathocalyx, CyathoStenna, Cynbopetalun, DaSOcienna, DaSynaschalon, Deeringothamnus, Dendrokingstonia, Dennettia, DeSnopsis, DeSnOS, Diciinanona, Dielsiothamnus, Disepalun, Duckeanthus, Duguetia, Ellipeia, Ellipeiopsis, Enicosanthum, Ephedranthus, Exelia, Fissistigma, Fitzalania, FriesOdielsia, Froesiodendron, Fusaea, Gilbertiella, Goniothalamus, Greenwayodendron, Guania, Guatteria, Guatteriella, Guatteriopsis, HaploStichanthus, Heteropetalum, Hexalobus, Horn.Schuchia, Solona, LeteStudioxa, Lettowianthus, Mainea, Marsypopetalun, Meiocarpidium, Meiogyne, Melodorum, Mezzettia, Mezzettiopsis, Miliusa, Mischogyne, Mitrella, Mitrephora, Mkilua, Monanthotaxis, Monocarpia, Monocyclanthus, Monodora, NeoStenanthera, Neo-uvaria, OncodoStigma, Onychopetalun, Ophrypetalum, Oreonitra, Orophea, Oxandra, Pachypodanthium, Papualithia, Petalolophus, Phaeanthus, Phoenicanthus, Piptostigma, Platymitra, Polyaithia, Polyaulax, Polyceratocarpus, Popowia, Porcelia, Pseudartabotrys, Pseudephedranthus, Pseudoxandra, Pseudu varia, Pyramidanthe, Raimondia, Reedrollinsia, Richella, Rollinia, Ruizodendron, Sageraea, Sapranthus, Schefferomitra, Sphaerocoryne, Stelechocarpus, Stenanona, Tetrameranthus, Tetrapetalum, Toussaintia, Tridineris, Trigynaea, Trivalvaria, Unonopsis, Uvaria, Uvariastrum, Uvariodendron, Uvariopsis, Woodiellantha, Xylopia. (3) dichapetalaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. alkaloids, saponins, Dahlgren's Superorder Malviflorae; Euphorbiales. aluminium salts, Cronquist's Subclass Rosidae; Celastrales. APG (1998) oligosaccharides, sucrose Eudicot; core Eudicot; Rosid; Eurosid I; Malpighiales. Species 200. Genera 3: Dichapetalum, Stephanopodium, Tapura, (Gonypetalum, Falya) (4) Annoceae Schefferonitra Subaequalis, Goniothaianus Sesquipedalis Alkaloids, cyanidins, flavonols, eg. kaempferol, quercetin, and myricetin; Saponins/sapogenins Sugars as sucrose, oligosaccharides or sugar alcohols (5) Cynosuraceae Aegilopaceae, Agrostidaceae, Alopecuraceae, alkaloids, arthroquinones, Andropogonaceae, Anonochloaceae, Anthoxanthaceae, proanthocyanidins, Arundinaceae, ArundineliaceaeAspereliaceae, Avenaceae cyanidins, flavonols, Bambusaceae, Chaeturaceae, Chloridaceae, Coleanthaceae kaempferol, quercetin, Cynosuraceae, Echinariaceae, Ehrhartiaceae, myricetin, elagic acid, Eragrostidaceae, Festucaceae, Glyceriaceae, Gramineae aluminium, Sucrose and Hordeaceae, Lepturaceae, Maydaceae, Melicaceae, oligosaccharides Miliaceae, Nardaceae, Oryzaceae, Panicaceae, US 2005/0181.077 A1 Aug. 18, 2005

TABLE I-continued

PLANT COMPOUNDS Pappophoraceae, Paspalaceae, Parianaceae, Phalaridaceae, Pharaceae, Saccharaceae, Spartinaceae, Sporoboiaceae, Stipaceae, Streptochaetaceae, Tristeginaceae, Triticaceae, Zeaceae (6) Asclepiadacea Taxonomy. Subclass Dicotyledonae; Tenuinucelli. alkaloids, hydrocitric acid, Dahlgren's Superorder Gentianiflorae; . L-carnitine, 3B glucuronides Cronquist's Subclass Asteridae; Gentianales. APG (1998) of different acetylated Eudicot; core Eudicot; Asterid; Euasterid I; Gentianales (as gymnemagenins, gymnemic a synonym of Apocynaceae). Species 2000. Genera 250; acid a complex mixture of at Absolnsia, AdeloStenna, Aidomene, Amblyopetalun, least 9 closely related acidic AnbiyStigma, Anatropanthus, Anisopus, Anisotona, glucosides, flavonols Anonotassa, Araujia, , AspidogloSSun, including kaempferol, A.Stephanus, Barionia, Belo.Stenna, Bidaria, Biondia, kaempferol and quercetin, , , Brachysteina, Calotropis, aluminium, Sucrose and Campestigma, Caraliuna, , Cibirhiza, Cioniura, oligosaccharides, iridoids. Clemensiella, Conomitra, Cordylogyne, Corolonema, CoSnoStigma, CoStantina, CyathoSteina, Cynanchun, Dactylostelna, Dalzielia, Decabelone, Decanema, Decanenopsis, Dicarpophora, Diplolepis, DiploStigma, Dischidanthus, Dischidia, Ditassa, Dittoceras, Dolichopetalun, DolichoStegia, Dory.Stephania, Dregea, DrepanoStenna, Duvalia, Duvaliandra, , Edithcotea, Enicocarpus, Enpiectranthus, Eustegia, Fanninia, Fischeria, Fockea, Foiotsia, Frerea, Funastrum, Genianthus, GioSSonena, GioSSOSteina, , Gongronena, Gonioantheina, GonioStenna, Gonolobus, Graphistenna, GunneSSia, Gymnena, Gymnenopsis, Harmandiella, , HeteroStemma, Heynella, Hickenia, HoloStemma, , X-Hoodiopsis, Hoya, Hoyella, Huernia, Huerniopsis, Hypolobus, IschnoStemma, Jacaina, Janakia, Jobinia, Kanahia, Karimboiea, Curb, Labido.Steina, Lagoa, , Leichardtia, , Lhotzkyella, Lugonia, Lygisna, MacroditaSSa, Macropetalum, Macroscepis, Mahafalia, Mahawoa, Manothrix, Margaretta, , Matellea, , Meresaldia, Merrillanthus, Metaplexis, Metastelna, Micholitzea, Microdactylon, Microlonna, Microstelna, Miraglossum, Mitostigma, Morrenia, Nautonia, Nematostemma, NeOSchumannia, Nephradenia, , Odontanthera, Odontostelma, Oncinema, OncoStemma, Ophionella, , Orbeanthus, Orbeopsis, Oreosparte, Orthanthera, Orthosia, , Pachycarpus, Pachycymbium, Papuastelma, Parapodium, Pectinaria, Pentalbothra, Pentacyphus, , PentaSachme, Pentastelma, , Peplonia, , Periglossum, Petalostelna, Petopentia, Pherotrichis, , Platykeleba, Pleurostelna, Podandra, Podostelma, ProSopostelma, , Ptycanthera, Pycnoneurum, Pycnorhachis, Quaqua, Quisumbingia, Raphistemma, , RhynchoStigma, Rhyssolobium, Rhyssostelna, , , Rojasia, Sarcolobus, SarcoStenna, Schistogyne, Schistonema, SchizogioSSun, Schubertia, ScyphoSteina, Secanone, Secanonopsis, SeShagiria, Sisyranthus, SolenoStenna, Sphaerocodon, Spirelia, Stapeia, Stapeianthus, Stapeiopsis, StathmoSteina, SteleoStenna, Steinagonun, Steinatocodon, Stenomeria, Stenosteina, Stigmatorhynchus, Strobopetalum, Stuckertia, Swynnertonia, Tassadia, Tavaresia, Telminostelna, TeloSma, Tenaris, Tetracustelma, Tetraphysa, Thozetia, , Treutlera, Trichocaulon, Trichosacne, TrichoSandra, Tridentea, Tromotriche, Tweedia, , Tylophoropsis, Vailia, Vincetoxicopsis, , Voharanga, Vohenaria, White-Sloanea, Widgrenia, Woodia, (7) Combretaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. alkaloids, arthroquinones, Dahlgren's Superorder Myrtiflorae; Myrtales. Cronquist's proanthocyanidins, Subclass Rosidae; Myrtales. APG (1998) Eudicot; core cyanidins, flavonols, Eudicot; Rosid; Eurosid II; Myrtales. Species 600. Genera kaempferol, quercetin, US 2005/0181.077 A1 Aug. 18, 2005

TABLE I-continued

PLANT COMPOUNDS about 20; Anogeissus, Buchenavia, Bucida, Calopyxis, myricetin, elagic acid, Calycopteris, Combretum, Conocarpus, Dan Siea, Guiera, aluminium, Sucrose and Laguncularia, Lumnitzera, Macropteranthes, MelloStenon, oligosaccharides Pteleopsis, Quisqualis, Strephonema, Terminalia, Terminaliopsis, Thiloa (8) Amaranthaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. Cyanogenics, alkaloids, Dahlgren's Superorder Caryophylliflorae; Caryophyllales. flavonols, quercetin, elagic Cronquist's Subclass Caryophyllidae; Caryophyllales. APG acid, betalains, saponins, (1998) Eudicot; core Eudicot; neither Rosid nor Asterid; Sapogenins, Oxalates Caryophyllales. Species 850. Genera 74: Achyranthes, Achyropsis, Aerva, Aimania, Alternanthera, Anaranthus, Arthraerula, Biutaparon, BoSea, Brayulinea, Caicorena, Celosia, Centenna, Centenopsis, CentroStachys, Chanissoa, Charpentiera, Chionothrix, Cyathula, Dasysphaera, Dasysphaera, Deeringia, Digera, Eriostylos, Froelichia, Gomphrena, Gossypianthus, Guilleminea, Hebanthe, Hemichroa (-Chenopodiaceae), Henonia, Herbstia, Hermbstaedtia, Indobanalia, Irenella, Iresine, Kyphocarpa, Lagrezia, Leucosphaera, Lithophia, Lopriorea, Marcelliopsis, Mechowia, Nelsia, Neocentenna, Nothosaerva, Nototrichium, Nyssanthes, Pandiaka, Pfafia, Philoxerus, Pleuropetalum, Pleuropterantha, Polyrhabda, Pseudogomphrena, Pseudoplantago, PseudoSericocona, Psilotrichopsis, Psilotrichum, Ptilotus, Pupaia, Quaternelia, Rosifax, Saitia, Sericocona, Sericoconopsis, Sericorema, Sericostachys, Sianosia, Stilbanthus, Tidestronia, Trichuriella, Volkensinia, Woehleria, Xerosipho (9) Araceae Taxonomy. Subclass Monocotyledonae. Superorder Cyanogenics, cynogenic Ariflorae; Arales. APG (1998) Monocot; non-commelinoid; constituents tyrosine-derived, Alismatales. Species 2000. Genera 106; Agiaodorum, alkaloids, proanthocyanidins, Agiaonena, Alloschenone, Aiocasia, Ambrosina, cyanidin, flavonols, Amorphophalius, Amydrium, Anadendrum, Anaphyllopsis, kaempferol, quercetin, and Anaphyllum, Anchonanes, Anthurium, Anubias, Aridarun, quercetin Ariopsis, Arisaena, Arisarum, Arophyton, Arun, AsteroStigma, Biarum, Bognera, Bucephalandra, Caladium, Calla, Callopsis, Carlephyton, Cercestis, Chlorospatha, Colletogyne, Colocasia, Cryptocoryne, Cuicasia, Cyrtosperma, Diefenbachia, Dracontioides, Dracontium, Dracunculus, Eminium, Epiprennun, Filarum, FurtOdoa, Gearum, Gonatanthus, Gonatopus, Gorgonidium, Gymnostachys, Hapaline, Helicodiceros, Heteroaridarum, Heteropsis, Holochlamys, Homalomena, Hottarum, Jasarum, Lagenandra, Lasia, LaSimorpha, LySichiton, Mangonia, Monstera, Montrichardia, Nephthytis, Orontium, Pedicellarum, Peitandra, Philodendron, Phymatarum, Pinellia, Piptospatha, Pistia, Podolasia, Pothoidium, Pothos, Protarum, Pseudodracontium, PseudohydroSme, Pycnospatha, Remusatia, Raphidophora, RhodoSpatha, Sauronatun, Scaphispatha, Schismatoglottis, Scindapsus, Spathantheun, Spathicarpa, Spathiphyllum, Stenospernation, Steudinera, Stylochaeton, Synpiocarpus, Synandrospadix, Syngonium, Taccarum, Theriophonium, Typhonium, Typhonodorun, Ulearun, Urospatha, Urospathelia, XanthoSona, Zanicuicas, ZantedeSchia, Zonicarpa, Zonicarpeiia (10) Cyperaceae Taxonomy. Subclass Monocotyledonae. Superorder Alkaloids, Commeliniflorae; Cyperales. APG (1998) Monocot; proanthocyanidins, Commelinoid group: . Species about 5000. Genera cyanidins, delphinidins about 120; Abildgaardia, Acritius, ActinoSchoenus, flavonols, quercetins, Afrotrilepis, Ainula, Androtrichun, Anosporum, aluminium ArthroStylis, ASColepis, AScopholis, Baeothryon, Baumea, Becquerelia, Bisboeckelera, Blysmopsis, Blysmus, BolboSchoenus, Bulbostylis, Calyptrocarya, Capitularina, Carex, Carpha, Caustis, Cephalocarpus, Chorizandra, Chrysitrix, Cladium, Coleochloa, Costularia, Courtoisina, CrOSSiandia, Cyathochaeta, Cyathocona, Cynophyllus, Cyperus, DeSnOSchoenius, Didymiandrum, Dipiacrum, US 2005/0181.077 A1 Aug. 18, 2005

TABLE I-continued

PLANT COMPOUNDS Diplasia, Dulichium, Egleria, Eleocharis, Eleogiton, Epischoenus, Eriophoropsis, Eriophorun, ErioScirpus, Evandra, Everardia, Exocarya, Exochogyne, Ficinia, Fimbristylis, Fuirena, Gahnia, GymnoSchoenus, Hellmuthia, Hemicarpha, Hymenochaeta, Hypolytrium, Solepis, Kobresia, Kyllinga, Kyllingieia, Lagenocarpus, Lepidosperma, Lepironia, Lipocarpha, LophoSchoenus, Machaerina, Mapania, Mapaniopsis, Mariscus, Mesomelaena, Microdracoides, Micropapyrus, Monandrus, Morelotia, Neesenbeckia, Nemum, Nelmesia, Oreobolopsis, Oreobolus, Oxycaryum, Paramapania, Phylloscirpus, Pleurostachys, Principlina, PseudoSchoenus, Ptilanthelium, Pycreus, Queenslandiella, Reedia, Remirea, Rhynchocladium, Rhynchospora, Rikiella, Schoenoplectus, Schoenoxiphium, Schoenoides, Schoenus, Scirpodendron, Scirpoides, Scirpus, Scleria, Sphaerocyperus, SumatroScirpus, Syntrinema, Tetraria, Tetrariopsis, Thoracostachyum, Torulinium, Trachystylis, Trianoptiles, TrichoSchoenus, Tricostularia, Trilepis, Tylocarya, Uncinia, Vesicarex, Voikiella, Websteria. (11) Anacardiaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. Alkaloids, iridoids, Dahlgren's Superorder Rutiflorae, . Cronquist's proanthocyanidins, Subclass Rosidae; Sapindales. APG (1998) Eudicot; core delphinidins, cyanidins, Eudicot; Rosid; Eurosid II; Sapindales. Species 600. Genera flavonols, eg. kaempferol, about 70; Actinocheita, Anacardium, Androtium, quercetin, and myricetin; Antrocaryon, ApterokarpoS, Astronium, Baronia, Saponins/sapogenins Sugars Bonetiella, Boulea, Buchanania, Campnosperna, as sucrose, oligosaccharides Cardena Siodendron, Choerospondias, Conocladia, or sugar alcohols Cotinus, Cyrtocarpa, Dracontonelon, Drinnycarpus, Ebandoua, Euleria, EurOSchinus, Faguetia, Feginnanra, Gluta, Haematostaphis, Haplorhus, Harpephyllum, Heeria, Holigarna, Koordersiodendron, Lannea, Laurophyllus, Lithrea, Loxopterigium, LOxOStylis, Mangifera, Mauria, Melanochyla, Metopium, Micronychia, Montagueia, Mosquitoxylum, Nothopegia, Ochoterenaea, Operculicarya, Ozoroa, Pachycornus, Parishia, Pegia, Pentaspadon, Pleiogynium, Poupartia, Protorhus, Pseudoprotorhus, PseudoSnodingium, Pseudospondias, Rhodosphaera, Rhus, Schinopsis, Schinus, Sclerocarya, Senecarpus, Snodingium, Solenocarpus, Sorindeia, Spondias, Swintonia, Tapirira, Thyrsodium, Toxicodendron, Trichoscypha. (12) Bignoniaceae Taxonomy. Subclass Dicotyledonae; Tenuinucelli. Alkaloids, iridoids Dahlgren's Superorder Lamiiflorae; Scrophulariales. arthroquinones, shikimic Cronquist's Subclass Asteridae; Scrophulariales. APG acid, verbascosides, (1998) Eudicot; core Eudicot; Asterid; Euasterid I; cornosides, flavonols, . Species 650. Genera 110; Adenocalymna, quercetins, ursolic acid, Amphilophium, Amphitecna, Anemopaegna, Argylia, Saponins, Sapogenins Arrabidaea, Astianthus, Barnettia, , Callichlamys, oligosaccharides, sucrose, CampSidium, Campsis, Catalpa, , Sugar Ceratophytum, Chiopsis, Clytostona, Collea, Crescentia, Cuspidaria, Cybistax, DeioStona, Depianchea, Digomphia, Dinklageodoxa, Distictella, Distictis, Dolichandra, , Eccrenocarpus, Ekmanianthe, , Fridericia, Gardnerodoxa, Giaziova, Godmania, Haploiophium, Haplophragma, , Hieris, Incarvillea, Jacaranda, Kigelia, Laniodendron, Leucocailantha, Lundia, Macfadyena, Macranthiisiphon, ManaoSella, Mansoa, Markhania, Martinelia, Melloa, Memora, Millingtonia, Mussatia, Neoiobertia, NeoSepicaea, , Nyctealos, Ophiocolea, Oroxylum, Paianelia, Pandorea, Parabiognonia, Paragonia, Paratecoma, Parmentiera, Pauldopia, Perianthomega, Periarrabidaea, Perichlaena, Phryganocydia, , Phyloctenium, Piriadacus, Pithecoctenium, Pleionotona, Podranea, Potanoganos, Pseudocatalpa, PyroStegia, , , Rhodocolea, Roentgenia, Romeroa, Saritaea, Sparattosperma, Spathicalyx, , Sphingiphia, Spirotecoma, , Stizophyllum, Tabebuia, Tanaecium, Teconna, Teconnanthe, Teconnelia, Tourrettia, US 2005/0181.077 A1 Aug. 18, 2005

TABLE I-continued

PLANT COMPOUNDS Tynanthus, Urbanolophium, Xylophragma, Zeyheria. For discussion of classificatory problems posed by Scrophulariaceae, impinging on Bignoniaceae, Buddleiaceae, Callitrichaceae, Plantaginaceae, Hippuridaceae, Lentibulariaceae, and HydroStachydaceae, and such problem genera as Paulownia and Schlegelia, see Olmstead and Reeves (1995). (13) Bombacaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. Alkaloids, Dahlgren's Superorder Malviflorae; . Cronquist's proanthocyanidins, Subclass Dilleniidae; Malvales. APG (1998) Eudicot; core cyanidins, flavonols e.g. Eudicot; Rosid; Eurosid II; Malvales. Species 180. Genera kaempferol and quercetin; 30; Adansonia, Aguiaria, , Bombacopsis, SCOSC Bombax, Catostenna, Cavaniliesia, Ceiba, Chorisia, Coelostegia, Cullenia, Durio, Eriotheca, Gyranthera, Huberodendron, Kosternansia, Matisia, Neesia, Neobuchia, Ochroma, Pachira, Patinoa, Phragmotheca, Pseudobombax, Quaranibea, Rhodognaphalon, Rhodagnaphaiopsis, Scleronema, Septotheca, Spirotheca. , Bombacaceae, Sterculiaceae and Tiliaceae (14) Anacardiaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. Alkaloids, arthroquinones, Dahlgren's Superorder Rutiflorae, Sapindales. Cronquist's proanthocyanidins, Subclass Rosidae; Sapindales. APG (1998) Eudicot; core delphinidin, cyanidin, Eudicot; Rosid; Eurosid II; Sapindales. Species 600. Genera flavonols, kaempferol, about 70; Actinocheita, Anacardium, Androtium, quercetin, myricetin, elagic Antrocaryon, ApterokarpoS, Astronium, Baronia, acid, saponins, Sapogenins, Bonetiella, Boulea, Buchanania, Campnosperna, sucrose, oligosaccharides, Cardenasiodendron, Choerospondias, Conocladia, sugar alcohols Cotinus, Cyrtocarpa, Dracontoneion, Drinnycarpus, Ebandoua, Euleria, EurOSchinus, Faguetia, Feginnanra, Gluta, Haematostaphis, Haplorhus, Harpephyllum, Heeria, Holigarna, Koordersiodendron, Lannea, Laurophyllus, Lithrea, Loxopterigium, LOxOStylis, Mangifera, Mauria, Melanochyla, Metopium, Micronychia, Montagueia, Mosquitoxylum, Nothopegia, Ochoterenaea, Operculicarya, Ozoroa, Pachycornus, Parishia, Pegia, Pentaspadon, Pleiogynium, Poupartia, Protorhus, Pseudoprotorhus, PseudoSnodingium, Pseudospondias, Rhodosphaera, Rhus, Schinopsis, Schinus, Sclerocarya, Senecarpus, Sorindeia Snodingium, Solenocarpus, , Spondias, Swintonia, Tapirira, Thyrsodium, Toxicodendron, Trichoscypha. (15) Caricaceae Taxonomy. Subclass Dicotyledonae; Crassinucelli. mustard-oils, alkaloids, Dahlgren's Superorder Violiflorae; Violales. Cronquist's saponins/sapogenins Subclass Dilleniidae; Violales. APG (1998) Eudicot; core Eudicot; Rosid; Eurosid II; Brassicales. Species 55. Genera 4; Carica, CylicOnorpha, Jacaratia, Jaria.

0040 Prior to the administration to a patient an extract or potency of the extract(s) the route of administration of the a mixture of extracts are typically diluted by combination formulation, and the mechanical System used to administer with a pharmecologically compatible Solvent, e.g., ethanol the formulation. A therapeutically effective amount of a or water to produce a therapeutic Solution. Typically the particular extract or mixture of extracts can be Selected by amount or concentration of the extract or mixed extracts in those of ordinary skill in the art with due consideration of the therapeutic solution ranges from 0.0001 to 10.0 weight Such factors. Generally a therapeutically effective amount percent of the total weight of the solution. Of course, the will be from about 0.005 parts weight to about 2 parts by extract or mixture of extracts is present in a therapeutically weight based on 100 parts by weight of the therapeutic effective amount, that is, an amount Such that the extract or Solution, or if in Solid form, e.g., tablet or capsule, 0.001 to mixture of extracts can be administered in a therapeutically 10 parts by weight of the weight of the tablet or capsule. effective amount through conventional oral, nasal, aeroSol, topical, intravenous, peritoneal, etc. means. 0042. For oral administration, either solid or fluid unit dosage forms can be prepared. For preparing Solid compo 0041. The term “amount” as used herein refers to a Sitions Such as tablets, the extract or extract mixture is mixed quantity or to a concentration, as appropriate to the context. into formulations with conventional ingredients, Such as The amount of extract(s) that constitutes a therapeutically talc, magnesium Stearate, dicalcium phosphate, magnesium effective amount varies according to factorS Such as the aluminum Silicate, calcium Sulfate, Starch, lactose, acacia, US 2005/0181.077 A1 Aug. 18, 2005

methylcellulose, and functionally similar materials as phar of active material calculated to produce the desired phar maceutical diluents or carriers. Capsules are prepared by maceutical effect in association with the required pharma mixing the extract or extract mixture with an inert pharma ceutical diluent, carrier or vehicle. The Specifications for the ceutical diluent and filling the mixture into a hard gelatin unit dosage forms of this invention are dictated by and capsule of appropriate size. Soft gelatin capsules are pre dependent on (a) the unique characteristics of the active pared by machine encapsulation of a Slurry of the extract or material and the particular effect to be achieved and (b) the extract mixture with an acceptable vegetable oil, light liquid limitations inherent in the art of compounding Such an active petrolatum or other inert oil. material for use in humans and animals. 0.043 Fluid unit dosage forms for oral administration 0048 Examples of unit dosage forms are tablets, cap Such as Syrups, elixirs and Suspensions can be prepared. The Sules, pills, powder packets, wafers, Suppositories, granules, water Soluble forms can be dissolved in an aqueous vehicle cachets, teaspoonfuls, dropperfuls, ampoules, Vials, aerosols together with Sugar, aromatic flavoring agents and preser with metered discharges, Segregated multiples of any of the Vatives to form a Syrup. An elixir is prepared by using a foregoing, and other forms as herein described. hydroalcoholic (e.g., ethanol) vehicle with Suitable Sweet 0049. Thus, a formulation of the invention includes a enerS Such as Sugar and Saccharin, together with an aromatic therapeutic extract(s) which may be formulated with con flavoring agent. Suspensions can be prepared with an aque ventional, pharmaceutically acceptable, vehicles for topical, ous vehicle with the aid of a Suspending agent Such as oral or parenteral administration. Formulations may also acacia, tragacanth, methylcellulose and the like. include Small amounts of adjuvants Such as buffers and 0044) Appropriate formulations for parenteral use are preservatives to maintain isotonicity, physiological and pH apparent to the practitioner of ordinary skill. Usually, the Stability. Means of preparation, formulation and administra therapeutic extract or extract mixture is prepared in an tion are known to those of skill. See generally Remington's queous Solution in a concentration of from about 1 to about Pharmaceutical Science 15" ed., Mack Publishing Co., 10 mg/ml. More typically, the concentration is from about Easton, Pa. (1980). 10 to about 20 mg/ml. The formulation, which is sterile, is 0050 Slow or extended-release delivery systems, includ Suitable for various parenteral routes including intra-dermal, ing any of a number of biopolymers (biological-based intraarticular, intra-muscular, intravascular, and Subcutane Systems), Systems employing liposomes, and polymeric OUIS. delivery Systems, can be utilized with the extracts described 0045. In addition to the therapeutic extract or extract herein to provide a continuous or longterm source of thera mixture the compositions may include, depending on the peutic compound. Such slow release Systems are applicable formulation desired, pharmaceutically-acceptable, non-toxic to formulations for topical, ophthalmic, oral, and parenteral carriers or diluents, which include vehicles commonly used Sc. to form pharmaceutical compositions for animal or human 0051 Delivery of the inventive therapeutic extractor administration. The diluent is Selected So as not to unduly extract mixture is usually by oral administration as a Solu affect the biological activity of the combination. Examples tion. However, where necessary, therapy, e.g., intra-dermal, of Such diluents which are especially useful for injectable intra-articular, intramusular or intravenous, is also formulations are water, the various Saline Solutions, Ringer's employed. Solution, dextrose Solution, and Hank's Solution. In addition, the pharmaceutical composition or formulation may include 0052 AS previously indicated, the resultant medicament additives Such as other carriers, adjuvants, or nontoxic, extract e.g., from a Single plant or a mixture of any of the nontherapeutic, nonimmunogenic Stabilizers and the like. afore-mentioned plants, has been found to be effective in 0046. Furthermore, excipients can be included in the treating AIDS but also in treating associated conditions formulation. Examples include coSolvents, Surfactants, oils, related to AIDS. Such associated conditions include recur humectants, emollients, preservatives, Stabilizers and anti rent and persistent fever, chronic diarrhea, dermatitis, gen oxidants. Any pharmacologically acceptable buffer may be eralized lymphodenpathy, persistent cough, general pain, used, e.g., tris or phosphate buffers. Effective amounts of tuberculosis, and amenorrhea. diluents, additives and excipients are those amounts which EXAMPLES are effective to obtain a pharmaceutically acceptable formu 0053 1. About 105 patients suffering from AIDS were lation in terms of Solubility, biological activity, etc. treated with mixtures of plant extracts, obtained as above 0047 The term “unit dosage form” refers to physically described as approximately 10% weight percent therapeutic discrete units Suitable as unitary dosages for human Subjects solutions with the following results as reported in TABLE II, and animals, each unit containing a predetermined quantity below.

TABLE II

Combinations of Plant Extract Medicaments for Treatment of AIDS Related Ailments Stage of AIDS Disease Typical Symptoms Mixture of Plant Extract Used Stage 1: Critically ill - non Significant weight loss Apocynaceae (17 weight percent) ambulatory patients Frequent and recurrent Fever Annonaceae (10 weight percent) 3-6 months duration of Chronic Diarrhea Dichapetalaceae (14 weight percent) treatment Dermatitis Annoceae (17 weight percent) US 2005/0181.077 A1 Aug. 18, 2005 10

TABLE II-continued

Combinations of Plant Extract Medicaments for Treatment of AIDS Related Ailments Stage of AIDS Disease Typical Symptoms Mixture of Plant Extract Used (Complete 90 to 98%) Generalized Lymphodenpathy, Cynocynaceae (21 weight percent) Cough Asclepiadaceae (14 weight percent) General Pain Combretaceae (7 weight percent) Pneumonia Diluted with Kaposi's sarcoma to give a 0.5 to 25 weigh Herpes zoster percent extracts solution Tuberculosis Amenorrhea Stage 2: Moderately ill - after going Lack of appetite Apoocynaceae (15 weight percent) through stage 1 treatment program Immune dysfunction Amaranthaceae (17 weight percent) 3-6 months duration of treatment Aroceae (17 weight percent) (Complete 95%) Cyperaceae (17 weight percent) Anacardiaceae (17 weight percent) bignoniaceae (17 weight percent) Diluted with water to give a 0.5 to 25% weight percent extract solution Stage 3: Relatively ill Restoration of immune protection Anoceae (17 weight percent) but ambulatory with good vitals Anarcadiaceae (20 weight percent) after stage 2 program Aroceae (20 weight percent) 3-6 months duration of treatment Bombacaceae (20 weight percent) Caricaceae (17 weight percent) Combretaceae (6 weight percent) Diluted with water to give a 0.5 to 25 weight percent extract solution ORAL DOSAGES: Adults 3 tablespoonsfull 3 times daily Pediatric: 2 teaspoonful 3 times daily

0054) II. Treatment of HIV Patients For AIDS Related Ailments TABLE III-continued 0.055 A total of 300 patients presenting moderate to Approximate Recovery Time advanced Stages of AIDS, particularly with respect to debili Symptom (Average) tating ailments, including persistent fever, chronic diarrhea, Tuberculosis 12 Weeks dermatitis, generalized lymphodenapathy, persistent cough, Amenorrhea 1 Week general pain, tuberculosis and amenorrhea, were treated with an extract mixture Solution of the invention. The mixture comprised Anoceae (10 to 20 weight percent), Anarcadi We claim: aceae (15-20 weight percent), Araceae (15 to 20 weight 1. An AIDS and associated conditions related to AIDS percent) Bombacaceae (20 weight percent), Caricaceae (15 treating composition which comprises: to 20 weight percent), and Combretaceae (3 to 10 weight percent). The mixture was then diluted with water to give a medicament Selected from an extract of at lease one of about 10 weight percent extract Solution. The Solution was the following plant families: (1) Apocynaceae (Pleios administered to each patient at a dose of 3 tableSpoons three carpa Bicarpellata), (2) Annonaceae (Cleistopholis times per day. Patens); (3) Dichapetalaceae (Dichapetehan Mada gasca Riense); (4) Annoceae (Uvaristrum Pierre 0056 All treated patients in this group of studies had anum); (5) Cynocynaceae (Strophantus Gratus); (6) none of the debilitating Symptoms in the time periods Asclepiadaceae (Gongronema Latifolium); (7) Com indicated in TABLE III, below: bretaceae (Combretum Racemosum); (8) Apocynaceae (Alsotonia boonei); (9) Amaranthaceae (Alternanthera TABLE III Pungens); (10) Aroceae (Anchomanes Differmis); (11) Cyperaceae (Seleria Voivinil); (12) Anacardiaceae Approximate Recovery Time (Lannea Acida); (13) Bignoniaceae (Kigelia Africana); Symptom (Average) (14) Bombacaceae (Ceiba Pentanoia); (15) Anarcardi R/P Fever 1 Week aceae (); (16) Bombacaceae Chronic Diarrhea 1 Week Dermatitis 3 Weeks (Bombax BounopOzense); (17) Anarcardiaceae (Spon Generalizied Lymphodenpathy 4 Weeks dias Mombin); (18) Caricaceae (Carica Papaya); (19) Cough 2. Weeks a glyceryle of any of the foregoing extracts; (20) a General Pain 4 Weeks Saponin of any of the foregoing extracts; (21) an alkaloid of any of the foregoing extracts; (22) a protein US 2005/0181.077 A1 Aug. 18, 2005

of any of the foregoing extracts; (23) a fat of the 4. The composition of claim 2 where said alkaloid is foregoing extracts; (24) a Sugar of any of the foregoing Selected from a true alkaloid, a proto alkaloid, or a pseudo extracts, and (25) any mixture of any of the foregoing. alkaloid with or without a heterocyclic nitrogen. 2. The composition of claim 1 where the glyceryl ester is 5. The composition of claim 4 where said heterocyclic Selected from the group consisting of a fatty ester derived nitrogen is derived from Ornithine, tyrosine, tryptophane, from Stearic, oleic, lauric, palmitic, myristic, erucic acids, pyrindine or lysine (b) a fatty alcohol ester derived from tridecyl stearate, cetyl palmitate, Stearyl Stearate, ceto Stearyl Stearate (c) a glyceryl 6. A method of treating AIDS and a condition related ester derived from glyceryl mono laurate, glyceryl mono thereto in a patient in need thereof which comprises, treating palmitate, glyceryl mono Stearate, glyceryl mono oleate, the patient with the composition as defined in claim 1. glyceryl mono ricinoleate; (d) a Sorbitan ester derived from 7. The method as defined in claim 6 wherein the related Sorbitan mono laurate, Sorbitan mono palmitate, Sorbitan condition is Selected from the group consisting of R/P fever, mono Stearate, Sorbitan mono oleate, Sorbitan triStearate, chronic diarrhea, dermatitis, generalized lymphodenpathy, Sorbitan trioleate, Sorbitan Sesquioleate; (e) glycerol, (f) cough, general pain, tuberculosis, amenorrhea and a com propylene glycol, (g) polyethylene glycol, (h) pentaerythi bination of any of the foregoing conditions. tol, and (i) a congenser ester Selected from (i) polyethylene glycol laurates/Stearates/oleates (ii) polyethylene glycol 8. The method of claim 6 wherein said composition is mono/distearate, (iii) propylene glycol mono/distearate (iv) administered to the patient by an administration Selected pentaerythritol mono/di/tetra oleate, (1) a trimethylolpro from the group consisting of orally, nasally; rectally, by pane ester Selected from (i) trilaurate/triooleate; and () a injection by internal routes of administration and by a polygycerol ester Selected from Stearates, oleates, and rici combination of the foregoing administration. noleates. 9. A method of treating a patient in need thereof to restore 3. The composition of claim 2 where the Saponins com a compromised immune System which comprises treating prise a glycosidic compound comprising of a steriod (c-27) the patient with the composition as defined in claim 1. or triterpenoid (c-30) Saponin nucleus with one or more carbohydrate branches.