Behavioral Neuroscience and Psychopharmacology
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Behavioral Neuroscience Uab Graduate Handbook
Behavioral Neuroscience Ph.D. Program Policies, Guidelines, & Procedures Student Handbook 2021-2022 University of Alabama at Birmingham Table of Contents Mission Statement __________________________________________ 3 History of the Program _______________________________________ 3 Policies and Procedures ______________________________________ 4 Overview of Student Career ___________________________________ 5 Typical Courses ____________________________________________ 5 Progress Reports ___________________________________________ 6 2nd Year Research Project __________________________________ 7 Qualifying Examination _______________________________________ 8 Dissertation ________________________________________________ 10 Behavioral Neuroscience Student Checklist _______________________ 13 Master’s Degree ____________________________________________ 15 Policies Regarding Adequate Progress __________________________ 16 Policies on Remunerated Activities _____________________________ 16 Vacation, Leave, Holiday Guidelines ____________________________ 17 Degree Requirements and Associated Procedures ________________ 18 2 BEHAVIORAL NEUROSCIENCE PROGRAM Mission Statement and History of the Program Mission Statement Behavioral neuroscience is represented by scientists with interests in the physiological and neural substrates of behavior. The mission of the Behavioral Neuroscience Ph.D. program is to produce outstanding young scientists capable of pursuing independent research careers in the field of behavioral neuroscience by providing graduate -
Introduction to Psychopharmacology
1 Introduction to Psychopharmacology CHAPTER OUTLINE • Psychopharmacology • Why Read a Book on Psychopharmacology? • Drugs: Administered Substances That Alter Physiological Functions • Psychoactive Drugs: Described by Manner of Use • Generic Names, Trade Names, Chemical Names, and Street Names for Drugs • Drug Effects: Determined by Dose • Pharmacology: Pharmacodynamics, Pharmacokinetics, and Pharmacogenetics • Psychoactive Drugs: Objective and Subjective Effects • Study Designs and the Assessment of Psychoactive Drugs • Validity: Addressing the Quality and Impact of an Experiment • Animals and Advancing Medical Research • Researchers Consider Many Ethical Issues When Conducting Human Research • From Actions to Effects: Therapeutic Drug Development • Chapter Summary sychoactive substances have made an enormous impact on society. Many people regularly drink alcohol or smoke tobacco. Millions of Americans take P prescribed drugs for depression or anxiety. As students, scholars, practitioners, and everyday consumers, we may find that learning about psychoactive substances can be invaluable. The chapters in this book provide a thorough overview of the Domajor not classes of psychoactive copy, drugs, including post, their actions inor the body distributeand their effects on behavior. 1 Copyright ©2018 by SAGE Publications, Inc. This work may not be reproduced or distributed in any form or by any means without express written permission of the publisher. 2 Drugs and the Neuroscience of Behavior Psychopharmacology Psychopharmacology Psychopharmacology is the study of how drugs affect mood, perception, think- Study of how drugs ing, or behavior. Drugs that achieve these effects by acting in the nervous system affect mood, perception, thinking, or behavior are called psychoactive drugs. The term psychopharmacology encompasses two large fields: psychology and pharmacology. Thus, psychopharmacology attempts to Psychoactive drugs Drugs that affect mood, relate the actions and effects of drugs to psychological processes. -
Joan Y. Chiao
JOAN Y. CHIAO Department of Psychology Northwestern University 2029 Sheridan Rd, Evanston, IL 60208 Email: [email protected] Phone: 847.467.0481 ACADEMIC POSITIONS 2006-present Assistant Professor, Department of Psychology, Northwestern University Affiliated Faculty, Neuroscience Institute (NUIN) Affiliated Faculty, Cognitive Science Program Affiliated Faculty, Asian American Studies Program Affiliated Faculty, Cognitive Neurology and Alzheimer’s Disease Center Affiliated Faculty, Multidisciplinary Program in Educational Science Affiliated Faculty, Technology and Social Behavior Program Faculty Associate, Institute for Policy Research EDUCATION Ph.D. Harvard University in Psychology, 2001-2006 B.S. Stanford University in Symbolic Systems with Honors, 1996-2000 RESEARCH INTERESTS • Social affective and cultural neuroscience • Race and its influence on perception, cognition and emotion • Psychological and neural mechanisms underlying social status and dominance • Integration of psychology and neuroscience research to public policy and population health issues HONORS, AWARDS and FELLOWSHIPS 2011 Association for Psychological Science Rising Star Award 2011 NIMH Early Career International Travel Award 2006-07 Japan Society for the Promotion of Science Research Fellow 2003-06 National Science Foundation Graduate Research Fellowship 2005 John Merck Summer Institute: Biology of Developmental Disabilities Allport Travel Funds, Harvard George W. Goethals Teaching Prizes, Harvard Cognitive Neuroscience Society Graduate Student Presenter Award -
From Sacred Plants to Psychotherapy
From Sacred Plants to Psychotherapy: The History and Re-Emergence of Psychedelics in Medicine By Dr. Ben Sessa ‘The rejection of any source of evidence is always treason to that ultimate rationalism which urges forward science and philosophy alike’ - Alfred North Whitehead Introduction: What exactly is it that fascinates people about the psychedelic drugs? And how can we best define them? 1. Most psychiatrists will define psychedelics as those drugs that cause an acute confusional state. They bring about profound alterations in consciousness and may induce perceptual distortions as part of an organic psychosis. 2. Another definition for these substances may come from the cross-cultural dimension. In this context psychedelic drugs may be recognised as ceremonial religious tools, used by some non-Western cultures in order to communicate with the spiritual world. 3. For many lay people the psychedelic drugs are little more than illegal and dangerous drugs of abuse – addictive compounds, not to be distinguished from cocaine and heroin, which are only understood to be destructive - the cause of an individual, if not society’s, destruction. 4. But two final definitions for psychedelic drugs – and those that I would like the reader to have considered by the end of this article – is that the class of drugs defined as psychedelic, can be: a) Useful and safe medical treatments. Tools that as adjuncts to psychotherapy can be used to alleviate the symptoms and course of many mental illnesses, and 1 b) Vital research tools with which to better our understanding of the brain and the nature of consciousness. Classifying psychedelic drugs: 1,2 The drugs that are often described as the ‘classical’ psychedelics include LSD-25 (Lysergic Diethylamide), Mescaline (3,4,5- trimethoxyphenylathylamine), Psilocybin (4-hydroxy-N,N-dimethyltryptamine) and DMT (dimethyltryptamine). -
Social Neuroscience and Psychopathology: Identifying the Relationship Between Neural Function, Social Cognition, and Social Beha
Hooker, C.I. (2014). Social Neuroscience and Psychopathology, Chapter to appear in Social Neuroscience: Mind, Brain, and Society Social Neuroscience and Psychopathology: Identifying the relationship between neural function, social cognition, and social behavior Christine I. Hooker, Ph.D. ***************************** Learning Goals: 1. Identify main categories of social and emotional processing and primary neural regions supporting each process. 2. Identify main methodological challenges of research on the neural basis of social behavior in psychopathology and strategies for addressing these challenges. 3. Identify how research in the three social processes discussed in detail – social learning, self-regulation, and theory of mind – inform our understanding of psychopathology. Summary Points: 1. Several psychiatric disorders, such as schizophrenia and autism, are characterized by social functioning deficits, but there are few interventions that effectively address social problems. 2. Treatment development is hindered by research challenges that limit knowledge about the neural systems that support social behavior, how those neural systems and associated social behaviors are compromised in psychopathology, and how the social environment influences neural function, social behavior, and symptoms of psychopathology. 3. These research challenges can be addressed by tailoring experimental design to optimize sensitivity of both neural and social measures as well as reduce confounds associated with psychopathology. 4. Investigations on the neural mechanisms of social learning, self-regulation, and Theory of Mind provide examples of methodological approaches that can inform our understanding of psychopathology. 5. High-levels of neuroticism, which is a vulnerability for anxiety disorders, is related to hypersensitivity of the amygdala during social fear learning. 6. High-levels of social anhedonia, which is a vulnerability for schizophrenia- spectrum disorders, is related to reduced lateral prefrontal cortex (LPFC) activity 1 Hooker, C.I. -
Dissociating Hippocampal Versus Basal Ganglia Contributions to Learning and Transfer
Dissociating Hippocampal versus Basal Ganglia Contributions to Learning and Transfer Catherine E. Myers1, Daphna Shohamy1, Mark A. Gluck1, Steven Grossman1, Alan Kluger2, Steven Ferris3, James Golomb3, 4 5 Geoffrey Schnirman , and Ronald Schwartz Downloaded from http://mitprc.silverchair.com/jocn/article-pdf/15/2/185/1757757/089892903321208123.pdf by guest on 18 May 2021 Abstract & Based on prior animal and computational models, we Parkinson’s disease, and healthy controls, using an ‘‘acquired propose a double dissociation between the associative learning equivalence’’ associative learning task. As predicted, Parkin- deficits observed in patients with medial temporal (hippo- son’s patients were slower on the initial learning but then campal) damage versus patients with Parkinson’s disease (basal transferred well, while the hippocampal atrophy group showed ganglia dysfunction). Specifically, we expect that basal ganglia the opposite pattern: good initial learning with impaired dysfunction may result in slowed learning, while individuals transfer. To our knowledge, this is the first time that a single with hippocampal damage may learn at normal speed. task has been used to demonstrate a double dissociation However, when challenged with a transfer task where between the associative learning impairments caused by previously learned information is presented in novel recombi- hippocampal versus basal ganglia damage/dysfunction. This nations, we expect that hippocampal damage will impair finding has implications for understanding the distinct -
Behavioral Epigenetics and the Developmental Origins of Child Mental Health Disorders
Journal of Developmental Origins of Health and Disease (2012), 3(6), 395–408. REVIEW & Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 doi:10.1017/S2040174412000426 Behavioral epigenetics and the developmental origins of child mental health disorders B. M. Lester1,2,3,4*, C. J. Marsit5, E. Conradt1,4, C. Bromer6 and J. F. Padbury3,4 1Brown Center for the Study of Children at Risk at Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA 2Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA 3Department of Pediatrics, Warren Alpen Medical School of Brown University, Providence, RI, USA 4Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA 5Departments of Pharmacology & Toxicology and Community & Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA 6Department of Neuroscience, Brown University, Providence, RI, USA Advances in understanding the molecular basis of behavior through epigenetic mechanisms could help explain the developmental origins of child mental health disorders. However, the application of epigenetic principles to the study of human behavior is a relatively new endeavor. In this paper we discuss the ‘Developmental Origins of Health and Disease’ including the role of fetal programming. We then review epigenetic principles related to fetal programming and the recent application of epigenetics to behavior. We focus on the neuroendocrine system and develop a simple heuristic stress-related model to illustrate how epigenetic changes in placental genes could predispose the infant to neurobehavioral profiles that interact with postnatal environmental factors potentially leading to mental health disorders. -
Social Cognitive Neuroscience: a Review of Core Systems
C HAPTER 2 2 SOCIAL COGNITIVE NEUROSCIENCE: A REVIEW OF CORE SYSTEMS Bruce P. Doré, Noam Zerubavel, and Kevin N. Ochsner Descartes famously argued that the mind is both SOCIAL COGNITIVE NEUROSCIENCE everlasting and indivisible (Descartes, 1988). If he APPROACH was right about the first part, he is probably pretty In the past decade, the field of social cognitive neuro- impressed with the advance of human knowledge science (SCN) has attempted to fill this gap, integrat- on the second. Although Descartes’ position on ing the theories and methods of two parent the indivisibility of the mind has been echoed at disciplines: social psychology and cognitive neurosci- times in the history of psychology and neurosci- ence. Stressing the interdependence of brain, mind, ence (Flourens & Meigs, 1846; Lashley, 1929; and social context, SCN seeks to explain psychological Uttal, 2003), the modern field has made steady phenomena at three levels of analysis: the neural level progress in demonstrating that subjective mental of brain systems, the cognitive level of information life can be understood as the product of distinct processing mechanisms, and the social level of the functional systems. Today, largely because of the experiences and actions of social agents (Ochsner & success of cognitive neuroscience models, Lieberman, 2001). In contrast to scientific approaches researchers understand that people’s intellectual that grant near exclusive focus to a single level of anal- faculties emerge from the operation of core ysis (e.g., behaviorism, artificial -
Handbook of Psychopharmacology
Handbook of Psychopharmacology Volume 7 Principles of Behavioral Pharmacology Handbook of Psychopharmacology SECTION I: BASIC NEUROPHARMACOLOGY Volume 1 Biochemical Principles and Techniques in Neuropharmacology Volume 2 Principles of Receptor Research Volume 3 Biochemistry of Biogenic Amines Volume 4 Amino Acid Neurotransmitters Volume 5 Synaptic Modulators Volume 6 Biogenic Amine Receptors SECTION II: BEHAVIORAL PHARMACOLOGY IN ANIMALS Volume 7 Principles of Behavioral Pharmacology Volume 8 Drugs, Neurotransmitters, and Behavior Volume 9 Chemical Pathways in the Brain SECTION III: HUMAN PSYCHOPHARMACOLOGY Volume 10 N euro leptics and Schizophrenia Volume 11 Stimulants Volume 12 Drugs of Abuse Volume 13 Biology of Drug Effects in Affective Disorders Volume 14 Anxiety and Affective Disorders: Drug Actions in Man Volume 7 Principles of Behavioral Pharmacology Edited by Leslie L. Iversen Department of Pharmacology University of Cambridge Susan D. Iversen Department of Psychology University of Cambridge and Solomon H. Snyder Departments of Pharmacology and Psychiatry The Johns Hopkins University School of Medicine PLENUM PRESS • NEW YORK AND LONDON Library of Congress Cataloging in Publication Data Main entry under title: Handbook of psychopharmacology. Includes bibliographies and indexes. CONTENTS: v. 1. Biochemical principles and techniques in neuropharmacology. -v. 2. Principles of receptor research.-v. 3. Biochemistry of biogenic amines.-v. 4. Amino acid neurotransmitters.-v. 5. Synaptic modulators.-v. 6. Biogenic amine receptors.-v. 7. Principles of behavioral pharmacology. 1. Psychopharmacology. I. Iversen, Leslie Lars. II. Iversen, Susan D., 1940- III. Snyder, Solomon H., 1938- [DNLM: 1. Psychopharmacology. QV77 H236j RC483.H36 615.78 75-6851 lSBN-13: 978-1-4613-4216-8 e-lSBN-13: 978-1-4613-4214-4 DOl: 10.1007/978-1-4613-4214-4 © 1977 Plenum Press, New York Softcover reprint of the hardcover 1st edition 1977 A Division of Plenum Publishing Corporation 227 West 17th Street, New York, N.Y. -
Before They Called It Psychopharmacology* Heinz E
NEUROPSYCHOPHARMACOLOGY 1993-VOL. 8, NO. 4 291 SPECIAL LECTURE Before They Called It Psychopharmacology* Heinz E. Lehmann, M.D. BEFORE THEY CALLED IT Johns Hopkins, who called the domain of psychophar PSYCHOPHARMACOLOGY macology "certainly very meager." Macht conducted pharmacologic experiments with opium narcotics and It is a great privilege and honor to be here today, giv coal tar analgesics on reaction time, tapping speed, etc., ing the second annual lecture on the history of psy much as Kraepelin as early as 1883 had done in Wundt's chopharmacology. My friend Frank Ayd did such an laboratory with alcohol and caffeine, calling it then Phar admirable job with his lecture last year, on the early macopsychologie (Macht 1920). history, that I have had a hard problem finding gaps W. Freeman, in 1931, wrote a more general paper to fill. What I have finally chosen to do is to trace for in the Journal of the American Medical Association on you some of the early history, complete with anecdotes, what he called psychochemistry, and in 1935 Thorner which preceded our modern notions of psychology and wrote the fIrst paper resembling our modern concept pharmacology and then to tell you something of my of the term with "Psychopharmacology of Sodium own experiences and findings in the psychiatric world Amytal in Catatonia." I will discuss this paper in more of the 1940s and 1950s, a world that was remarkably detail later . After a careful search of the modern litera different and simplistic compared to today. I also in ture, I came to the conclusion that official general use tend to give you a subjective "oral history" of my own of the term psychopharmacology in publications dates stumbling attempts to make some sense out of the only to 1960, following a paper by Ross and Cole enti vague and somewhat chaotic potpourri of ideas and tled "Psychopharmacology," when also psychophar pharmacologic approaches to psychiatric problems a macology appears for the fIrst time as a free-standing half century ago. -
Psychopharmacology, Neuropharmacology & Toxicology Expertise
Psychopharmacology, Neuropharmacology & Toxicology Expertise October 2013 Dr Ken Gillman MBBS Re: MAOI anti-depressant drugs MRC Psych Dear Doctor and Colleague, Expert in A patient who wishes to consider treatment with MAOI anti- Psycho- depressant drugs (e.g. “Parnate”, “Nardil”) has obtained this letter pharmacology from my website. I am Dr Ken Gillman MRCPsych, a retired Serotonin academic & clinical psychiatrist. I have published many papers about toxicity psycho-pharmacology and am internationally acknowledged as an Neuroleptic expert on serotonin syndrome (aka serotonin toxicity) and drug-drug malignant interactions generally. You may verify my publications via the NLM syndrome at: Drug http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&term=Gillman interactions P MAOIs or at Google scholar (which also shows their high citation frequency) at: TCAs http://scholar.google.com.au/citations?user=ea6KeD0AAAAJ&hl=en SSRIs and you can get the free pdf from the British Journal of Pharmacology website of one of my recent major reviews ‘Tricyclic antidepressant pharmacology and therapeutic drug interactions updated’. http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0707253/pdf I have also recently published a review of the MAOIs, ‘Advances pertaining to the pharmacology and interactions of irreversible nonselective monoamine oxidase inhibitors. J Clin Psychopharmacol, 2011. 31(1): p. 66-74’ I have had extensive experience of using monoamine oxidase inhibitor (MAOI) drugs (Nardil/phenelzine & Parnate/tranylcypromine) for severe and atypical depression and have written about this since these drugs are somewhat maligned and because reduced knowledge and awareness of them makes many doctors shy away from using them when they might be of considerable utility and benefit. -
Social Work and Neurosciences: Speeches and Theoretical Contributions
ISSN 2411-9563 (Print) European Journal of Social Science August 2018 ISSN 2312-8429 (Online) Education and Research Vol 5 No 2 DOI: 10.2478/ejser-2018-0046 Open Access. © 2018 João Cabral Sacadura and Helena Neves Almeida. This is an open access article licensed under the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 License Social Work and Neurosciences: Speeches and Theoretical Contributions M.ª João Cabral Sacadura, PhD Student, Catholic University of Portugal and University of Coimbra, Portugal Helena Neves Almeida, PhD Professor and Researcher. Faculty of Psychology and Education Sciences University of Coimbra, Portugal Abstract The concept of “neuroscience” sometimes referred to as “the last frontier of biology” (Squire et al., 2008, p. 3) was introduced in the mid-1960s and is now recognized as a multidisciplinary field that analyzes the nervous system to understand the biological basis of human behavior. The ongoing developments and the arising production regarding the deepening of the structure, functions and functioning of the brain and its interaction with the environment enabled the identification of key elements reaching an unprecedented level of knowledge in the history of humankind. The multidisciplinary scientific approach, including non-clinical areas such as music, philosophy, education, mathematics, economics and physics, has also contributed to its further deepening. In the light of this scenario of interdependencies and disciplinary alliances, the discipline of the social and human sciences – social work – whose subject is conceived “from and for the practice” (Parton, 1996) in the day-to-day work with challenging social problems of various types and with different publics. Therefore, the present article aims to analyze what has been done to date since 2001, namely the input and contributions of authors and researchers in the field as well as to understand the input of neuroscience developments in their education and research.