Psychedelic Resting-State Neuroimaging: a Review and Perspective on Balancing Replication and Novel Analyses
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Introduction to Neuroimaging
Introduction to Neuroimaging Janaina Mourao-Miranda • Neuroimaging techniques have changed the way neuroscientists address questions about functional anatomy, especially in relation to behavior and clinical disorders. • Neuroimaging includes the use of various techniques to either directly or indirectly image the structure or function of the brain. • Structural neuroimaging deals with the structure of the brain (e.g. shows contrast between different tissues: cerebrospinal fluid, grey matter, white matter). • Functional neuroimaging is used to indirectly measure brain functions (e.g. neural activity) • Example of Neuroimaging techniques: – Computed Tomography (CT), – Positron Emission Tomography (PET), – Single Photon Emission Computed Tomography (SPECT), – Magnetic Resonance Imaging (MRI), – Functional Magnetic Resonance Imaging (fMRI). • Among other imaging modalities MRI/fMRI became largely used due to its low invasiveness, lack of radiation exposure, and relatively wide availability. • Magnetic Resonance Imaging (MRI) was developed by researchers including Peter Mansfield and Paul Lauterbur, who were awarded the Nobel Prize for Physiology or Medicine in 2003. • MRI uses magnetic fields and radio waves to produce high quality 2D or 3D images of brain structures/functions without use of ionizing radiation (X- rays) or radioactive tracers. • By selecting specific MRI sequence parameters different MR signal can be obtained from different tissue types (structural MRI) or from metabolic changes (functional MRI). MRI/fMRI scanner MRI vs. fMRI -
Current Directions in Social Cognitive Neuroscience Kevin N Ochsner
Current directions in social cognitive neuroscience Kevin N Ochsner Social cognitive neuroscience is an emerging discipline that science (SCN) as a distinct interdisciplinary field that seeks to explain the psychological and neural bases of seeks to understand socioemotional phenomena in terms socioemotional experience and behavior. Although research in of relationships among the social (specifying socioemo- some areas is already well developed (e.g. perception of tionally relevant cues, contexts, experiences, and beha- nonverbal social cues) investigation in other areas has only viors), cognitive (information processing mechanisms), just begun (e.g. social interaction). Current studies are and neural (brain bases) levels of analysis. elucidating; the role of the amygdala in a variety of evaluative and social judgment processes, the role of medial prefrontal Here, I provide a brief synthetic review of selected recent cortex in mental state attribution, how frontally mediated findings organized around types or stages of processing controlled processes can regulate perception and experience, rather than topic domains for the following three reasons. and the way in which these and other systems are recruited First, a process orientation might help to highlight emerg- during social interaction. Future progress will depend upon ing functional principles that cut across topics. Second, the development of programmatic lines of research that SCN encompasses numerous topics, and for many of integrate contemporary social cognitive research with them -
Introduction to Psychopharmacology
1 Introduction to Psychopharmacology CHAPTER OUTLINE • Psychopharmacology • Why Read a Book on Psychopharmacology? • Drugs: Administered Substances That Alter Physiological Functions • Psychoactive Drugs: Described by Manner of Use • Generic Names, Trade Names, Chemical Names, and Street Names for Drugs • Drug Effects: Determined by Dose • Pharmacology: Pharmacodynamics, Pharmacokinetics, and Pharmacogenetics • Psychoactive Drugs: Objective and Subjective Effects • Study Designs and the Assessment of Psychoactive Drugs • Validity: Addressing the Quality and Impact of an Experiment • Animals and Advancing Medical Research • Researchers Consider Many Ethical Issues When Conducting Human Research • From Actions to Effects: Therapeutic Drug Development • Chapter Summary sychoactive substances have made an enormous impact on society. Many people regularly drink alcohol or smoke tobacco. Millions of Americans take P prescribed drugs for depression or anxiety. As students, scholars, practitioners, and everyday consumers, we may find that learning about psychoactive substances can be invaluable. The chapters in this book provide a thorough overview of the Domajor not classes of psychoactive copy, drugs, including post, their actions inor the body distributeand their effects on behavior. 1 Copyright ©2018 by SAGE Publications, Inc. This work may not be reproduced or distributed in any form or by any means without express written permission of the publisher. 2 Drugs and the Neuroscience of Behavior Psychopharmacology Psychopharmacology Psychopharmacology is the study of how drugs affect mood, perception, think- Study of how drugs ing, or behavior. Drugs that achieve these effects by acting in the nervous system affect mood, perception, thinking, or behavior are called psychoactive drugs. The term psychopharmacology encompasses two large fields: psychology and pharmacology. Thus, psychopharmacology attempts to Psychoactive drugs Drugs that affect mood, relate the actions and effects of drugs to psychological processes. -
Vascular Factors and Risk for Neuropsychiatric Symptoms in Alzheimer’S Disease: the Cache County Study
International Psychogeriatrics (2008), 20:3, 538–553 C 2008 International Psychogeriatric Association doi:10.1017/S1041610208006704 Printed in the United Kingdom Vascular factors and risk for neuropsychiatric symptoms in Alzheimer’s disease: the Cache County Study .............................................................................................................................................................................................................................................................................. Katherine A. Treiber,1 Constantine G. Lyketsos,2 Chris Corcoran,3 Martin Steinberg,2 Maria Norton,4 Robert C. Green,5 Peter Rabins,2 David M. Stein,1 Kathleen A. Welsh-Bohmer,6 John C. S. Breitner7 and JoAnn T. Tschanz1 1Department of Psychology, Utah State University, Logan, U.S.A. 2Department of Psychiatry, Johns Hopkins Bayview and School of Medicine, Johns Hopkins University, Baltimore, U.S.A. 3Department of Mathematics and Statistics, Utah State University, Logan, U.S.A. 4Department of Family and Human Development, Utah State University, Logan, U.S.A. 5Departments of Neurology and Medicine, Boston University School of Medicine, Boston, U.S.A. 6Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, U.S.A. 7VA Puget Sound Health Care System, and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, U.S.A. ABSTRACT Objective: To examine, in an exploratory analysis, the association between vascular conditions and the occurrence -
From Sacred Plants to Psychotherapy
From Sacred Plants to Psychotherapy: The History and Re-Emergence of Psychedelics in Medicine By Dr. Ben Sessa ‘The rejection of any source of evidence is always treason to that ultimate rationalism which urges forward science and philosophy alike’ - Alfred North Whitehead Introduction: What exactly is it that fascinates people about the psychedelic drugs? And how can we best define them? 1. Most psychiatrists will define psychedelics as those drugs that cause an acute confusional state. They bring about profound alterations in consciousness and may induce perceptual distortions as part of an organic psychosis. 2. Another definition for these substances may come from the cross-cultural dimension. In this context psychedelic drugs may be recognised as ceremonial religious tools, used by some non-Western cultures in order to communicate with the spiritual world. 3. For many lay people the psychedelic drugs are little more than illegal and dangerous drugs of abuse – addictive compounds, not to be distinguished from cocaine and heroin, which are only understood to be destructive - the cause of an individual, if not society’s, destruction. 4. But two final definitions for psychedelic drugs – and those that I would like the reader to have considered by the end of this article – is that the class of drugs defined as psychedelic, can be: a) Useful and safe medical treatments. Tools that as adjuncts to psychotherapy can be used to alleviate the symptoms and course of many mental illnesses, and 1 b) Vital research tools with which to better our understanding of the brain and the nature of consciousness. Classifying psychedelic drugs: 1,2 The drugs that are often described as the ‘classical’ psychedelics include LSD-25 (Lysergic Diethylamide), Mescaline (3,4,5- trimethoxyphenylathylamine), Psilocybin (4-hydroxy-N,N-dimethyltryptamine) and DMT (dimethyltryptamine). -
Effect of Dextromethorphan-Quinidine on Agitation in Patients with Alzheimer Disease Dementia a Randomized Clinical Trial
Research Original Investigation Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia A Randomized Clinical Trial Jeffrey L. Cummings, MD, ScD; Constantine G. Lyketsos, MD, MHS; Elaine R. Peskind, MD; Anton P. Porsteinsson, MD; Jacobo E. Mintzer, MD, MBA; Douglas W. Scharre, MD; Jose E. De La Gandara, MD; Marc Agronin, MD; Charles S. Davis, PhD; Uyen Nguyen, BS; Paul Shin, MS; Pierre N. Tariot, MD; João Siffert, MD Editorial page 1233 IMPORTANCE Agitation is common among patients with Alzheimer disease; safe, effective Author Video Interview and treatments are lacking. JAMA Report Video at jama.com OBJECTIVE To assess the efficacy, safety, and tolerability of dextromethorphan Supplemental content at hydrobromide–quinidine sulfate for Alzheimer disease–related agitation. jama.com DESIGN, SETTING, AND PARTICIPANTS Phase 2 randomized, multicenter, double-blind, CME Quiz at jamanetworkcme.com and placebo-controlled trial using a sequential parallel comparison design with 2 consecutive CME Questions page 1286 5-week treatment stages conducted August 2012–August 2014. Patients with probable Alzheimer disease, clinically significant agitation (Clinical Global Impressions–Severity agitation score Ն4), and a Mini-Mental State Examination score of 8 to 28 participated at 42 US study sites. Stable dosages of antidepressants, antipsychotics, hypnotics, and antidementia medications were allowed. INTERVENTIONS In stage 1, 220 patients were randomized in a 3:4 ratio to receive dextromethorphan-quinidine (n = 93) or placebo (n = 127). In stage 2, patients receiving dextromethorphan-quinidine continued; those receiving placebo were stratified by response and rerandomized in a 1:1 ratio to dextromethorphan-quinidine (n = 59) or placebo (n = 60). -
Brain Imaging Technologies
Updated July 2019 By Carolyn H. Asbury, Ph.D., Dana Foundation Senior Consultant, and John A. Detre, M.D., Professor of Neurology and Radiology, University of Pennsylvania With appreciation to Ulrich von Andrian, M.D., Ph.D., and Michael L. Dustin, Ph.D., for their expert guidance on cellular and molecular imaging in the initial version; to Dana Grantee Investigators for their contributions to this update, and to Celina Sooksatan for monograph preparation. Cover image by Tamily Weissman; Livet et al., Nature 2017 . Table of Contents Section I: Introduction to Clinical and Research Uses..............................................................................................1 • Imaging’s Evolution Using Early Structural Imaging Techniques: X-ray, Angiography, Computer Assisted Tomography and Ultrasound..............................................2 • Magnetic Resonance Imaging.............................................................................................................4 • Physiological and Molecular Imaging: Positron Emission Tomography and Single Photon Emission Computed Tomography...................6 • Functional MRI.....................................................................................................................................7 • Resting-State Functional Connectivity MRI.........................................................................................8 • Arterial Spin Labeled Perfusion MRI...................................................................................................8 -
Neuroimaging and the Functional Neuroanatomy of Psychotherapy
Psychological Medicine, 2005, 35, 1385–1398. f 2005 Cambridge University Press doi:10.1017/S0033291705005064 Printed in the United Kingdom REVIEW ARTICLE Neuroimaging and the functional neuroanatomy of psychotherapy JOSHUA L. ROFFMAN*, CARL D. MARCI, DEBRA M. GLICK, DARIN D. DOUGHERTY AND SCOTT L. RAUCH Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA ABSTRACT Background. Studies measuring the effects of psychotherapy on brain function are under-rep- resented relative to analogous studies of medications, possibly reflecting historical biases. However, psychological constructs relevant to several modalities of psychotherapy have demonstrable neuro- biological correlates, as indicated by functional neuroimaging studies in healthy subjects. This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders. Method. Fourteen published, peer-reviewed functional neuroimaging investigations of psycho- therapy were identified through a MEDLINE search and critically reviewed. Studies were compared for consistency of findings both within specific diagnostic categories, and between specific mod- alities of psychotherapy. Results were also compared to predicted neural models of psychother- apeutic interventions. Results. Behavioral therapy for anxiety disorders was consistently associated with attenuation of brain-imaging abnormalities in regions linked to the pathophysiology of anxiety, and with acti- vation in regions related to positive reappraisal of anxiogenic stimuli. In studies of major depressive disorder, cognitive behavioral therapy and interpersonal therapy were associated with markedly similar changes in cortical–subcortical circuitry, but in unexpected directions. For any given psy- chiatric disorder, there was only partial overlap between the brain-imaging changes associated with pharmacotherapy and those associated with psychotherapy. -
Behavioral Epigenetics and the Developmental Origins of Child Mental Health Disorders
Journal of Developmental Origins of Health and Disease (2012), 3(6), 395–408. REVIEW & Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012 doi:10.1017/S2040174412000426 Behavioral epigenetics and the developmental origins of child mental health disorders B. M. Lester1,2,3,4*, C. J. Marsit5, E. Conradt1,4, C. Bromer6 and J. F. Padbury3,4 1Brown Center for the Study of Children at Risk at Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI, USA 2Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA 3Department of Pediatrics, Warren Alpen Medical School of Brown University, Providence, RI, USA 4Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence, RI, USA 5Departments of Pharmacology & Toxicology and Community & Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA 6Department of Neuroscience, Brown University, Providence, RI, USA Advances in understanding the molecular basis of behavior through epigenetic mechanisms could help explain the developmental origins of child mental health disorders. However, the application of epigenetic principles to the study of human behavior is a relatively new endeavor. In this paper we discuss the ‘Developmental Origins of Health and Disease’ including the role of fetal programming. We then review epigenetic principles related to fetal programming and the recent application of epigenetics to behavior. We focus on the neuroendocrine system and develop a simple heuristic stress-related model to illustrate how epigenetic changes in placental genes could predispose the infant to neurobehavioral profiles that interact with postnatal environmental factors potentially leading to mental health disorders. -
Resting-State Fmri Reveals Network Disintegration During Delirium T ⁎ Simone J.T
NeuroImage: Clinical 20 (2018) 35–41 Contents lists available at ScienceDirect NeuroImage: Clinical journal homepage: www.elsevier.com/locate/ynicl Resting-state fMRI reveals network disintegration during delirium T ⁎ Simone J.T. van Montforta, , Edwin van Dellenb,c, Aletta M.R. van den Boscha,d, Willem M. Ottee,f, Maya J.L. Schutteb, Soo-Hee Choig, Tae-Sub Chungh, Sunghyon Kyeongi, Arjen J.C. Slootera, ⁎⁎ Jae-Jin Kimi, a Department of Intensive Care Medicine, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, The Netherlands b Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, the Netherlands c Melbourne Neuropsychiatry Center, Department of Psychiatry, University of Melbourne, Australia d Faculty of Science, University of Amsterdam, the Netherlands e Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht, Utrecht University, the Netherlands f Department of Pediatric Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, the Netherlands g Department of Psychiatry, Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea h Department of Radiology, Yonsei University Gangnam Severance Hospital, Seoul, Republic of Korea i Department of Psychiatry, Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea. ARTICLE INFO ABSTRACT Keywords: Delirium is characterized by inattention and other cognitive deficits, symptoms that have been associated with Delirium disturbed interactions between remote brain regions. Recent EEG studies confirm that disturbed global network fMRI topology may underlie the syndrome, but lack an anatomical basis. The aim of this study was to increase our Resting-state understanding of the global organization of functional connectivity during delirium and to localize possible Brain networks alterations. -
Electroencephalographic Resting-State Functional Connectivity of Benign Epilepsy with Centrotemporal Spikes
JCN Open Access ORIGINAL ARTICLE pISSN 1738-6586 / eISSN 2005-5013 / J Clin Neurol 2019;15(2):211-220 / https://doi.org/10.3988/jcn.2019.15.2.211 Electroencephalographic Resting-State Functional Connectivity of Benign Epilepsy with Centrotemporal Spikes Hyun-Soo Choia* Background and Purpose We aimed to reveal resting-state functional connectivity char- Yoon Gi Chungb* c acteristics based on the spike-free waking electroencephalogram (EEG) of benign epilepsy Sun Ah Choi with centrotemporal spikes (BECTS) patients, which usually appears normal in routine visual d Soyeon Ahn inspection. c Hunmin Kim Methods Thirty BECTS patients and 30 disease-free and age- and sex-matched controls Sungroh Yoona were included. Eight-second EEG epochs without artifacts were sampled and then bandpass Hee Hwangc filtered into the delta, theta, lower alpha, upper alpha, and beta bands to construct the associa- Ki Joong Kime,f tion matrix. The weighted phase lag index (wPLI) was used as an association measure for EEG signals. The band-specific connectivity, which was represented as a matrix of wPLI values of a Department of Electrical and all edges, was compared for analyzing the connectivity itself. The global wPLI, characteristic Computer Engineering, path length (CPL), and mean clustering coefficient were compared. Seoul National University, Seoul, Korea Results The resting-state functional connectivity itself and the network topology differed in bHealthcare ICT Research Center, the BECTS patients. For the lower-alpha-band and beta-band connectivity, edges that showed Seoul National University significant differences had consistently lower wPLI values compared to the disease-free con- Bundang Hospital, Seongnam, Korea c trols. -
Behavioral Neuroscience and Psychopharmacology
Behavioral Neuroscience and Psychopharmacology The Behavioral Neuroscience and Psychopharmacology area of concentration is designed to train students broadly in the general theoretical principles and technical approaches used to investigate the neurobehavioral mechanisms of alcohol and drug abuse. Psychopharmacological approaches to understanding basic principles of learning are also emphasized. Students receive a concentrated lab experience using either animal models (quail, mice or rats) or human subjects. Faculty in the program use different levels of analysis including cell culture models, neurochemical assays, developmental toxicology, classical conditioning of drug effects, operant conditioning, human behavioral pharmacology, and cognitive approaches to behavior. Students are expected to receive in depth training in at least one level of analysis although training that integrates more than one level of analysis is strongly encouraged. PROGRAM REQUIREMENTS COURSE REQUIREMENTS (1) Statistics sequence: PSY 610 - Experimental design PSY 611 - Correlational design (2) PSY 780 - Directed BNP studies PSY 780A - first year students only PSY 780B - first year and beyond (3) Any three proseminars selected from the following areas: Learning Cognitive processes Developmental Psychology Sensation & Perception Physiological Psychology (4) Four electives (a minimum of one of these must be outside of the Psychology Department) (see listing of some possible options on page **). (5) Additional course work as recommended by the advisory committee RESEARCH REQUIREMENTS It is expected that all students in the BNP area will be involved in research thorough out their course of study towards the Ph.D. The area has two formalized requirements that are designed to train the student in conducting research: (1) Master's thesis (2) Dissertation ALLIED AREA REQUIREMENT Each student is expected to develop an allied area to gain expertise in some area outside of the student's main research specialty.