Authors: Pallavi Subhraveti Ron Caspi Peter Midford Peter D Karp An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Ingrid Keseler Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. Gcf_000963905Cyc: Acetobacter aceti NBRC 14818 Cellular Overview Connections between pathways are omitted for legibility. Anamika Kothari a dicarboxylate a metal cation an amino phosphate a sulfonate phosphate acetate glycine betaine an amino an amino acid nitrate ammonium ammonium ammonium ethanolamine acid acid phosphate hydrogencarbonate gly predicted ABC RS00290 RS15790 RS13265 RS09910 Eat ActP RS05195 RS05160 RS12600 RS05170 transporter PstB RS04770 of phosphate

a sulfonate glycine betaine phosphate nitrate ammonium ammonium ammonium ethanolamine acetate an amino an amino an amino phosphate a metal gly hydrogencarbonate acid acid acid cation phosphate a dicarboxylate

Macromolecule Modification Aromatic Compound Biosynthesis Fermentation Amino Acid Degradation gln glutaminyl-tRNA Aminoacyl-tRNA Charging 6 ATP biosynthesis tRNA-uridine 2-thiolation N -(3-methylbut- a peptidoglycan queuosine at an [amino-group biosynthesis via transamidation a sulfurated a purine NADPH NAD + menadione NADH H + a nucleoside an L-asparaginyl- NAD(P) chorismate biosynthesis I pyruvate fermentation L-histidine 2-en-1-yl)- adenosylcobinamide RNA dimer (meso- glu position 34 carrier protein]- H + H + 3-(4-hydroxyphenyl) and selenation (bacteria) L-proline degradation I L-citrulline degradation L-glutamine triphosphate [tRNA Asn ] transhydrogenase to (S)-acetoin degradation II [sulfur carrier] 37 ribonucleoside Asp ADP degradation I adenosine diaminopimelate of a tRNA C-terminal-γ- glu D-erythrose pyruvate biosynthesis 5'-triphosphate F0F1 ATP in tRNA containing) (L-glutamate 5- 4-phosphate cys pyruvate NAD(P)(+) NADH-quinone N-acetyl- 3-deoxy-7- synthase: his pro L-citrulline gln DNA-directed aminoacyl- tRNA semialdehyde-2- tyr biosynthetic-type bifunctional transhydrogenase + F0F1 ATP + bifunctional ornithine tRNA (N6-isopentenyl : RNA polymerase penicillin- yl)-L-glutamategamma- H H phosphoheptulonate bifunctional atpC atpD cysteine acetolactate Asp-tRNA(Asn) adenosylcobinamide (Re/Si-specific): tRNA glutamyl- synthase proline carbamoyltransferase: adenosine(37)-C2)- B7445_RS04235 subunit omega: binding glutamyl- synthase class II: aspartate B7445_RS10660 desulfurase: synthase: ilvB ilvN /Glu-tRNA(Gln) kinase/ B7445_RS00605 : Q(34) gln urocanate dehydrogenase/L- argF methylthiotransferase B7445_RS04240 B7445_RS03140 protein phosphate an L-glutamyl- 3-deoxy- B7445_RS14720 transaminase/ B7445_RS10665 B7445_RS02005 (S)-2-acetolactate carbamoyl amidotransferase: adenosylcobinamide- B7445_RS00610 arfB synthetase an [amino-group glutamate gamma- MiaB: miaB B7445_RS04255 [+ 2 isozymes] 2: mrdA reductase: [tRNA Gln ] D-arabino- aspartate 4- B7445_RS10670 cysteine phosphate gatB gatA gatC phosphate B7445_RS00615 aminoacyl-tRNA GluQRS: carrier protein]- F0F1 ATP semialdehyde succinate nuoH nuoI argC H + H + Asp-tRNA(Asn) heptulosonate decarboxylase: F0F1 ATP desulfurase: [+ 5 isozymes] guanylyltransferase: hydrolase: gluQRS C-terminal-γ- synthase Asp-tRNA(Asn) dehydrogenase glutamine- dehydrogenase, Si-specific NAD(P)(+) B7445_RS04270 /Glu-tRNA(Gln) 7-phosphate 3-(4- B7445_RS13675 synthase: B7445_RS04505 glu cobU a peptidoglycan B7445_RS07925 (5-phospho- /Glu-tRNA(Gln) PutA: putA hydrolyzing hydrophobic transhydrogenase: nuoK nuoN RNA amidotransferase: 3-dehydroquinate hydroxyphenyl) B7445_RS11515 an [L-cysteine 4-imidazolone- (S)-1-pyrroline- with D,D cross- D-ala glutamyl- L-glutamyl)- amidotransferase: diacetyl carbamoyl- membrane anchor adenosyl- sthA NADH-quinone gatB gatA gatC synthase: pyruvate B7445_RS11520 desulfurase]-S- 5-propanoate 5-carboxylate links (meso- queuosine at L-glutamate H + RS04655 H + gatB gatA gatC phosphate protein: sdhD cobinamide oxidoreductase: [+ 5 isozymes] sulfanyl-L-cysteine diaminopimelate Asn a 5-phosphooxy- B7445_RS05855 B7445_RS11525 synthase: phosphate a purine asn tRNA position 34 tRNA charging acetoin reductase: nuoK nuoJ nuoI Asp B7445_RS11530 6 + containing) of a tRNA ammonium L-glutamyl- 3-dehydroquinate B7445_RS14175 carB carA N -(3-methylbut- ribonucleoside NADH NADP nuoH nuoG Gln 5'-deoxyadenosine an unsulfurated [tRNA ] 2-en-1-yl)-2- met 5'-diphosphate nuoE nuoC predicted ATP N-formimino- L-glutamate-5- carbamate [sulfur carrier] glu a tRNA glu type II 3- a [TusA sulfur- (S)-acetoin (methylsulfanyl) ABC Asp-tRNA(Asn) L-glutamate semialdehyde 37 dehydroquinate carrier protein]-S- adenosine urea transporter urea /Glu-tRNA(Gln) : aroQ sulfanyl-L-cysteine in tRNA + ser a tRNA ser a tRNA Ala ala tRNA asp asp gly a tRNA Gly bifunctional NAD menadiol of urea amidotransferase: elongator glutamate-- glycine cleavage val a tRNA Val arg a tRNA Arg leu a tRNA Leu pro a tRNA Pro tyr a tRNA Tyr ile a tRNA Ile met initiator tRNA Met met thr a tRNA Thr his a tRNA His trp a tRNA Trp lys a tRNA Lys cys a tRNA Cys phe a tRNA Phe proline gatB gatA gatC tRNA Met 3-dehydroshikimate tRNA : dehydrogenase/L- CO a [glycine-cleavage predicted Asn Gln N-formyl- 2 serine- alanine- B7445_RS06660 aspartate- glycine-- asn tRNA gln a tRNA a [TusD sulfur- glutamate gamma- 6 UDP-N-acetyl- undecaprenyl- a carboxy- a [bis(guanylyl a peptidoglycan shikimate complex H protein] N glycine cleavage system 3-aci- an L-cysteinyl- an L-cysteinyl- ABC an L-glutaminyl- valine-- -tRNA arginine-- leucine-- proline-- tyrosine-- -tRNA isoleucine-- methionine-- methionine-- glutamate-- threonine- -tRNA histidine-- tryptophan- lysine-- cysteine-- phenylalanine-- tRNA ligase: carrier protein]-S- L-glutamate semialdehyde α-D-glucosamine diphospho-N- adenylated- molybdopterin) a tRNA precursor dimer (E. faeciums) N-acetyl- urea urea dehydrogenase: -[(R)-lipoyl]-L-lysine aminomethyltransferase nitropropanoate cys cys Cys [tRNA Pro ] transporter [tRNA Gln ] sulfanyl-L-cysteine dehydrogenase [tRNA ] L-citrulline tRNA ligase: ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: ligase: tRNA ligase: tRNA ligase: tRNA ligase: tRNA ligase: -tRNA ligase: tRNA ligase: -tRNA tRNA ligase: tRNA ligase: tRNA ligase: pheS B7445_RS01155 B7445_RS08225 N-formylglutamate GcvT: gcvT acetylmuramoyl- [ThiS sulfur- of urea B7445_RS01185 serS B7445_RS02180 B7445_RS02210 B7445_RS04345 B7445_RS04515 alaS B7445_RS06415 B7445_RS06505 B7445_RS06505 B7445_RS08795 ligase: thrS aspS B7445_RS08085 ligase: trpS B7445_RS09450 B7445_RS10025 B7445_RS10860 B7445_RS01160 [+ 2 isozymes] amidohydrolase: PutA: putA glycine cleavage system L-alanyl-γ-D- carrier protein] chaperone]- aminomethyl- nitronate penicillin- B7445_RS07005 aminomethyltransferase glutamyl-L-lysyl- L-cysteine ribonuclease D: binding acetylornithine Cys- predicted an L-methionyl- shikimate glu transferring monooxygenase: aminoacyl- an L-valyl- an L-seryl- an L-arginyl- an L-leucyl- an L-prolyl- an L-tyrosyl- an L-alanyl- an L-isoleucyl- an L-methionyl- an L-glutamyl- an L-threonyl- an L-aspartyl- an L-histidyl- an L-tryptophanyl- an L-lysyl- an L-cysteinyl- an L-phenylalanyl- an L-asparaginyl- an L-glutaminyl- a [TusE sulfur N-formylglutamate GcvT: gcvT D-alanyl-D-alanine B7445_RS15020 protein deacetylase: tRNA(Pro) ABC Gly UDP-N- B7445_RS08070 cysteine tRNA Val ser Arg Leu Pro Tyr Ala Ile [elongator Met Glu Thr asp His Trp Lys Cys Phe a glycyl-[tRNA ] Asn Gln glycine choline choline [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [initiator tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] 34 carrier protein]-S amidohydrolase: [+ 2 isozymes] acetylglucosamine- desulfurase: cysteine ribonuclease 2: mrdA hydrolase: argE deacylase: transporter tRNA Met ] a uridine in tRNA dehydrogenase: nitronate -sulfanylcysteine B7445_RS08705 ybaK of choline gcvP -N-acetylmuramyl- monooxygenase: B7445_RS04505 desulfurase: D: rnd arfB acetylornithine a [glycine-cleavage a [glycine-cleavage (pentapeptide) B7445_RS01335 cysteine B7445_RS04505 a peptidoglycan aminoacyl-tRNA deacetylase: shikimate 3- tRNA 2- glu complex H protein] N 6 - pyrophosphoryl- argE glycine glycine complex H protein] N 6 desulfurase: cysteine tetramer with a D-ala hydrolase: RS00970 thiouridine(34) a nucleoside 5'- Pro betaine betaine phosphate L-methionine degradation aminomethyldihydrolipoyl- undecaprenol N- B7445_RS02005 desulfurase: a tRNA D,D cross-link B7445_RS07925 cys a tRNA synthase -dihydrolipoyl-L-lysine [unspecified monophosphate 3-phosphoshikimate 1- I (to L-homocysteine) L-lysine acetylglucosamine B7445_RS02005 (Enterococcus Carbohydrate Biosynthesis MnmA: mnmA 3-oxopropanoate nitrite degradation carboxyvinyltransferase: : a thiocarboxylated- faecium) acetate L-citrulline met B7445_RS14645 products] predicted B7445_RS07385 ditrans,octacis- ala [ThiS sulfur- a [bis(guanylyl cys a tRNA Cys 5-enolpyruvoyl- a 2-thiouridine 34 UDP AMP O-antigen building blocks biosynthesis (E. coli) β methionine ABC peptidoglycan biosynthesis I (meso-diaminopimelate containing) Cell Structure Biosynthesis ADP-L-glycero- -D-manno CMP-3-deoxy-D- GDP-mannose biosynthesis α in tRNA undecaprenyldiphospho- carrier protein] ala molybdopterin) sulfate sulfate lipid IV biosynthesis (P. putida) UDP- -D-glucose shikimate 3- adenosyltransferase: glycine cleavage system β transporter A lipid IV biosynthesis (E. coli) α -heptose biosynthesis N-acetyl-(N-acetyl- -D- cofactor A UDP- -D- α-D- D-glucopyranose manno-octulosonate biosynthesis phosphate α tRNA uridine-5- B7445_RS14505 aminomethyltransferase glucosaminyl)muramoyl- chaperone]-S- of sulfate UDP-N-acetyl- -D-glucosamine a (3R)-3- galactose glucopyranose 6-phosphate D-sedoheptulose biosynthesis D-glucopyranose chorismate SAM a (3R)-3- UDP- bifunctional D-glucopyranose carboxymethylaminomethyl(34) GcvT: gcvT L-alanyl-γ-D-glutamyl-L- sulfanyl-L-cysteine UDP-N-acetylglucosamine hydroxydecanoyl- 1-phosphate 7-phosphate D-ribulose 6-phosphate synthase: UDP-N-acetyl- hydroxytetradecanoyl- UDP-N-acetyl- galactopyranose glucose-1-phosphate transaldolase/ D-sedoheptulose bifunctional 6-phosphate synthesis GTPase MnmE: mnmE lysyl-D-alanyl-D-alanine sulfate RS09895 sulfate 1-carboxyvinyltransferase: [acp] α 5-phosphate phosphomannomutase/ aroC -D-glucosamine [acp] α-D-glucosamine mutase: glf thymidylyltransferase phosoglucose 7-phosphate D-arabinose transaldolase/ tRNA uridine-5- murA phosphoglucomutase: UDP-Galf α RfbA: rfbA : isomerase: 5-phosphate phosoglucose carboxymethylaminomethyl(34) α acyl-ACP--UDP-N- dTDP- -D-glucose B7445_RS06950 chorismate L-serine degradation a mature peptidoglycan a DNA containing a [protein] N- a [protein]-L- L-alanyl-γ-D- UDP-N-acetyl- -D- acyl-ACP--UDP-N- B7445_RS04075 B7445_RS10600 isomerase: isomerase: α-D-glucopyranose synthesis MnmG: mnmG L-arginine degradation quinoxaline-2- acetylglucosamine O- D-glycero-D- (meso-diaminopimelate aryl-carrier protein an apurinic/ a [glutamine- terminal-formyl- glutamate-O 5 glutamyl-L-lysyl- ser sec sulfite RS13055 sulfite glucosamine-enolpyruvate acetylglucosamine O- dTDP- F6P aldehydo-D-B7445_RS15025 B7445_RS04075 1-phosphate a 5-carboxymethylaminomethyl- SAH VII (arginase 3 pathway) carboxyl adenylate ATP ATP roseoflavin a tRNA acyltransferase: lpxA manno-heptose containing) apyrimidinic site synthetase]- L-methionine -methyl-ester D-alanyl-D-alanine acyltransferase: lpxA glucose 4,6- F6P 34 5'-phosphate UDP-N-acetylmuramate 7-phosphate arabinose 5- UTP--glucose- 2-thiouridine in tRNA ser L-tyrosine dehydratase: glutamine-- arg dehydrogenase: murB UDP-3-O-[(3R)-3- D-glycero- phosphate 1-phosphate adenosylhomocysteinase: L-serine ala UDP-3-O-[(3R)-3- rfbB fructose-6- mannose-1-phosphate lytic murein acyl carrier endonuclease peptide chemotaxis penicillin- serine- sulfite RS11910 sulfite glu UDP-N-acetyl-α-D-muramate hydroxydecanoyl]- beta-D- uridylyltransferase protein S-nitrosylation B7445_RS07370 ammonia-: hydroxymyristoyl]-N- phosphate guanylyltransferase/ transglycosylase: protein: III: nth bifunctional [glutamine deformylase: response regulator binding bifunctional -tRNA N-acetyl-α-D- α dTDP-4-dehydro- manno- GalU: galU and denitrosylation B7445_RS10080 acetyl- -D-glucosamine α transaminase mannose-6- a 5-aminomethyl-2- 2-aminoprop- arginase: rocF B7445_RS06480 B7445_RS06100 synthetase] B7445_RS03790 protein-glutamate protein riboflavin kinase/ ligase: glutamate UDP-N-acetylmuramate- glucosamine UDP-3-O-acyl-N- 6-deoxy- -D- heptose-7- L-homocysteine bifunctional DNA- (isomerizing) D-arabinofuranose phosphate isomerase: UDP-α-D-glucose thiouridine 34 in tRNA a [protein]- 2-enoate [+ 3 isozymes] adenylyltransferase/ methylesterase: 2: mrdA FAD synthetase: serS racemase: murI -L-alanine ligase: UDP-3-O-acyl-N- acetylglucosamine glucopyranose phosphate [+ 7 isozymes] formamidopyrimidine [+ 2 isozymes] sulfite RS08110 sulfite : glmS 5-phosphate B7445_RS03850 L-cysteine [glutamine synthetase]- B7445_RS09965 B7445_RS09405 B7445_RS14650 acetylglucosamine deacetylase: dTDP-4- kinase: rfaE1 urea glycosylase/ dehydrorhamnose D-glucosamine D-glycero-β-D- 3-deoxy-8- D-mannopyranose L-ornithine a mature peptidoglycan DNA-(apurinic adenylyl-L-tyrosine L-alanyl-γ-D- D-glt deacetylase: B7445_RS14680 a mature peptidoglycan a quinoxaline-2- an N-terminal L- an L-seryl- phosphooctulonate 6-phosphate γ phosphorylase: formate glutamyl-L- roseoflavin α B7445_RS14680 UDP-3-O-(3- 3,5-epimerase: rfbC 6-phosphate manno-heptose with (L-alanyl- -D- strand (non- carboxyl-[aryl- or apyrimidinic a [protein]-α- D-ala sec UDP-N-acetyl- -D-muramoyl-L-alanine a 5-methylaminomethyl- AMP methionyl-[protein] [tRNA ] 2+ 2+ UDP-3-O-(3- 1,7-bisphosphate synthase: kdsA phosphomannomutase/ a [protein] 3- 2-iminopropanoate ornithine reducing terminus) site) lyase: mutM B7445_RS03690 MeOH lysyl-D-alanine adenine Zn RS10405 Zn hydroxymyristoyl) dTDP-4- phosphoglucosamine 2-thiouridine 34 in tRNA L-arginine degradation L-aspartate glutamyl-meso-2,6- carrier protein] L-glutamate phosphoglucomutase: nitrosothio- cyclodeaminase: dinucleotide UDP-N-acetylmuramoyl- hydroxydecanoyl) -α-D-glucosamine dehydrorhamnose mutase: KDO-8P III (arginine degradation I diaminopimeloyl-D- α B7445_RS11790 L-alanine--D-glutamate - -D-glucosamine UDP-3-O-(3- 3,5-epimerase: rfbC B7445_RS02435 B7445_RS06950 L-alanine decarboxylase/ alanine) tetrapeptide a [glutamine UDP-3-O-(3- α a 3'-terminal a 5'-phospho- synthetase]-O ligase: B7445_RS14635 hydroxymyristoyl) dTDP-4-dehydro- α-D-glucosamine D-glycero-β-D- -D-mannose agmatinase pathway) Zn 2+ RS01375 Zn 2+ asp pro unsaturated sugar [DNA] 4 hydroxymyristoyl) β 1-phosphate a 5-methylaminomethyl- -(5'-adenylyl) glucosamine N- -L-rhamnose 1-phosphate manno-heptose arg meso-diaminopimelate UDP-N-acetyl-α-D-muramoyl- glucosamine N- 2-(S-geranyl) bifunctional pyruvate -L-tyrosine acyltransferase: dTDP-4- bifunctional UDP-N- 1-phosphate mannose-1-phosphate acyltransferase: thiouridine 34 in tRNA aspartate L-glutamine L-alanyl-D-glutamate lpxD dehydrorhamnose heptose 1-phosphate α-Kdo guanylyltransferase/ a [protein]- lpxD acetylglucosamine S-nitrosoglutathione transaminase/ degradation II UDP-2-N,3-O-bis[(3R)- reductase: rfbD mannose-6- L-cysteine a ring-opened 7- a [glutamine α ε predicted D-ala UDP-2-N-[(3R)-3- diphosphorylase/ adenyltransferase: 3-deoxy-manno- agmatine aspartate 4- sn-glycerol a CDP- phosphoenol N ,N -diacetyl-lysyl- UDP-N-acetylmuramoyl- 3-hydroxytetradecanoyl]- dTDP-β-L- phosphate isomerase: methylguanine glu a (6S)-5- synthetase]-O H O a cytidine 34 lys ABC efflux glucosamine-1- rfaE1 S-(hydroxymethyl) decarboxylase: 3-phosphate diacylglycerol 2 pyruvate D-alanyl-D-alanine L-alanyl-D-glutamate-- hydroxydodecanoyl]- α-D-glucosamine octulosonate gln 4 GTP dGDP ATP Ile2 thiol transporter thiol rhamnose phosphate N- ADP-D-glycero-β- B7445_RS03850 a 5-methylaminomethyl- glutathione agmatinase: in DNA formyltetrahydrofolate -(5'-adenylyl) biotin in tRNA 2, 6-diaminopimelate D-alanine--D-alanine 3-O-[(3R)-3- cytidylyltransferase: B7445_RS13675 glutamate of a thiol UDP-2,3- acetyltransferase D-manno-heptose GDP-α-D- 2-(Se-phospho) dehydrogenase/ speB oxaloacetate -L-tyrosine ligase: B7445_RS14620 hydroxydecanoyl]- B7445_RS12070 34 synthase large penicillin- ligase: B7445_RS14660 diacylglucosamine mannose selenouridine in tRNA class III alcohol group α-D-glucosamine GlmU: glmU ADP- [+ 2 isozymes] subunit: gltB bifunctional DNA- CDP-diacylglycerol-- bifunctional GTPase binding tRNA α diphosphatase: α CMP-Kdo dehydrogenase: glycerol-3-phosphate 3- biotin--[acetyl- UDP-N-acetyl- -D-muramoyl-L-alanyl- D-alanyl-D-alanine UDP-2,3- peptidoglycan maturation (meso-diaminopimelate containing) N-acetyl- -D- glyceromanno- glu formamidopyrimidine folylpolyglutamate bifunctional [glutamine HflX: hflX pyruvate protein lysidine(34) predicted γ B7445_RS15395 B7445_RS10120 putrescine phosphatidyltransferase: CoA-carboxylase] -D-glutamyl-meso-2,6-diaminopimelate diacylglucosamine glucosamine heptose 6- glycosylase/ synthase/ synthetase] [+ 5 isozymes] kinase: pyk 2: mrdA synthetase ABC efflux UDP-2,3- UDP-α-D-galactofuranose pgsA ligase: diphosphatase: lipid II (meso 1-phosphate epimerase: rfaD a 5-methylaminomethyl- S-(hydroxysulfenamide) DNA-(apurinic dihydrofolate adenylyltransferase/ TilS: tilS thiol transporter thiol UDP-N-acetylmuramoyl- diacylglucosamine diaminopimelate containing) biosynthesis ADP-L-glycero-β- 2-selenouridine 34 glutathione or apyrimidinic synthase: [glutamine synthetase]- B7445_RS04290 of a thiol B7445_RS15395 bifunctional UDP-N- + tripeptide--D-alanyl-D- diphosphatase 1-(3-sn- phosphate H Nα,Nε-diacetyl- acetylglucosamine D-manno-heptose in tRNA site) lyase: mutM CMP B7445_RS09065 adenylyl-L-tyrosine 34 group alanine ligase: murF UDP-2,3- LpxI: lpxI UDP-α-D-glucose PRPP biosynthesis GDP pyruvate lysyl-D-alanine D-ala a lysidine phosphatidyl) phosphorylase: dGTP Ile2 diacylglucosamine UDP-glucose 4- diphosphorylase/ biotinyl-5'- in tRNA a sugar RS08570 a sugar -sn-glycerol B7445_RS03690 UDP-N-acetyl-α-D-muramoyl-L- diphosphatase lipid X a nascent peptidoglycan epimerase GalE: galE glucosamine-1- D-ribose 5- a [DNA]- a 5'-phospho- 2,6-diamino-4- a (6S)-5- adenylate γ α phosphate N- hydroxylamine nucleotide- hydroxy-5-(N-methyl) 4-oxo-2-pentenal 3-phosphate alanyl-γ-D-glutamyl-meso-2,6- di-trans,octa-cis-undecaprenyl phosphate LpxI: lpxI with (L-alanyl- -D-glutamyl- UDP- -D-galactose phosphate [DNA] formyltetrahydrofolate lipid-A- acetyltransferase ribose-phosphate tRNA processing 3'-phosphate formamidopyrimidine diaminopimeloyl-D-alanyl-D-alanine meso-2,6-diaminopimeloyl-D- UDP-galactopyranose pyrophosphokinase: a [glutamine- lipid X (P. putida) disaccharide alanyl-D-alanine) pentapeptide GlmU: glmU ADP synthetase]- a sugar RS03705 a sugar synthase: lpxB mutase: glf B7445_RS02255 a polycistronic Amine and Polyamine Degradation phospho-N- UDP-N-acetyl- L-tyrosine lipid-A- PRPP tRNA precursor acetylmuramoyl- lipid A disaccharide penicillin-binding penicillin-binding UDP-Galf α-D-glucosamine disaccharide (E. coli) ammonium ethanolamine utilization pentapeptide- protein 2: mrdA protein 2: creatinine allantoin degradation 4-aminobutanoate a sugar RS08230 a sugar synthase: lpxB a 7,8-dihydro- phosphoenol (S)-1-pyrroline- (E)-4-hydroxy-3- transferase: tetraacyldisaccharide B7445_RS14615 a mature peptidoglycan with Fatty Acid and Lipid Biosynthesis degradation I to ureidoglycolate II degradation I H O an N-modified a RNA-DNA hybrid lipid A a nascent peptidoglycan 8-oxoguanine diphosphate 2 5-carboxylate methylbut-2-en- a protein B7445_RS14630 4'-kinase: penicillin-binding (L-alanyl-γ-D-glutamyl-meso- ethanolamine adenine aminoacyl-[tRNA] dADP pyruvate disaccharide with (L-alanyl-γ-D-glutamyl- (ammonia producing) in DNA PRPP bifunctional 1-yl diphosphate B7445_RS08630 protein 2: mrdA 2,6-diaminopimeloyl-D-alanyl- a tRNA precursor ribonuclease creatinine 4-aminobutanoate flavodoxin- ATP- palmitate biosynthesis (type II fatty acid synthase) proline 2+ 2+ (P. putida) meso-2,6-diaminopimeloyl- D-alanine) pentapeptide octanoyl-[acyl-carrier D: rnd ethanolamine (S)-(+)-allantoin dependent dependent Mg RS09710 Mg undecaprenyldiphospho- lipid IV (E. coli) gondoate biosynthesis long-chain fatty with a 5' creatininase: 4-aminobutyrate- RdgB/HAM1 family non- ribonuclease HII: dehydrogenase/L- tetraacyldisaccharide A D-alanine) tetrapeptide a nascent peptidoglycan protein] biosynthesis ammonia-lyase: allantoinase bifunctional DNA- aminoacyl- (E)-4-hydroxy- Clp protease N-acetylmuramoyl-L-alanyl- (anaerobic) acid activation extension and ribonuclease D: B7445_RS08000 -2-oxoglutarate canonical purine NTP adenine B7445_RS01125 glutamate gamma- γ-D-glutamyl-meso-2,6- 4'-kinase: with D,D cross-links (meso- (mitochondria, yeast) a long 3' trailer B7445_RS15020 B7445_RS08960 PuuE: puuE formamidopyrimidine tRNA pyruvate 3-methylbut- ATP-binding L,D-transpeptidase: L,D-transpeptidase: an acetoacetyl-[acp] a long-chain creatine transaminase: pyrophosphatase: rdgB phosphoribosyltransferase: ribonuclease semialdehyde B7445_RS08630 diaminopimelate containing) eutC allantoate glycosylase/ hydrolase: kinase: pyk 2-enyl- subunit 2+ 2+ diaminopimeloyl-D-alanyl-D-alanine a malonyl-[acp] an oleoyl-[acp] gabT HI: rnhA dehydrogenase Mg RS07265 Mg lipid IV B7445_RS02515 B7445_RS02515 an acetoacetyl-[acp] fatty acid a tRNA precursor ethanolamine succinate DNA-(apurinic inorganic B7445_RS15490 arfB diphosphate ClpA: clpA A 3-oxoacyl-ACP acyl--CoA ligase: UDP-N- a nascent peptidoglycan with a mature peptidoglycan 3-oxoacyl-ACP with a 5' allantoate semialdehyde diphosphatase: ppa PutA: putA (P. putida) reductase B7445_RS11585 ammonia-lyase: or apyrimidinic aminoacyl-tRNA 2-C-methyl-D-synthase: ispG [+ 2 isozymes] acetylglucosamine- a nascent peptidoglycan (L-alanyl-γ-D-glutamyl-meso- a nascent peptidoglycan with (L-alanyl-γ-D-glutamyl- reductase ribonuclease D: extension and a amidohydrolase: γ FabG: fabG beta-ketoacyl- a long-chain ribonuclease B7445_RS11605 NAD-dependent site) lyase: mutM hydrolase: DNA a nucleoside 5'- pyruvate glu erythritol-2,4- -N-acetylmuramyl- with L,D cross links (meso- 2,6-diaminopimelate) tripeptide with (L-alanyl- -D-glutamyl- meso-2,6-diaminopimeloyl- a mature peptidoglycan FabG: fabG short 3' extension B7445_RS13275 a peptide ACP synthase fatty acyl-CoA D: rnd B7445_RS15020 succinate- AMP B7445_RS07925 monophosphate dATP cyclodiphosphate fluoride CrcB fluoride (pentapeptide) diaminopimelate containing) meso-2,6-diaminopimeloyl- with D,D cross-links (meso- 3-oxoacyl-[acyl- + D-alanine) tetrapeptide 3-oxoacyl-[acyl- ribonuclease acetaldehyde sarcosine semialdehyde phosphate H pyrophosphoryl- glycine) tetrapeptide diaminopimelate containing) carrier-protein] II: fabF ribonuclease D: polyribonucleotide ribonuclease (S)-ureidoglycine a [DNA]- a 5'-phospho- 7,8-dihydro- carrier-protein] fatty acid biosynthesis D: rnd dehydrogenase: 4-oxo-2-pentenal undecaprenol N- reductase: fabG B7445_RS15020 nucleotidyltransferase: pnp P protein nucleotide- [DNA] 8-oxoguanine a mature peptidoglycan with reductase: fabG initiation (type II) sarcosine oxidase B7445_RS00595 3'-phosphate an N-modified an uncharged Mg 2+ Mg 2+ acetylglucosamine a (3R)-3- an (11Z)-3-oxo- component: alcohol ApaG a mature peptidoglycan (L-alanyl-γ-D-glutamyl-meso- a (3R)-3- gamma subunit: amino acid tRNA Co 2+ Co 2+ transferase: hydroxybutanoyl-[acp] rnpA dehydrogenase [+ 2 isozymes] with L,D cross-links (meso- 2,6-diaminopimelate) tripeptide a mature peptidoglycan hydroxybutanoyl-[acp] icos-11-enoyl-[acp] acetyl-CoA B7445_RS10075 B7445_RS14645 diaminopimelate containing) γ AdhP: adhP with (L-alanyl- -D-glutamyl- 3-hydroxyacyl- 3-hydroxyacyl- 3-oxoacyl-[acyl- acetyl-CoA a tRNA a tRNA precursor acetyl-CoA (S)-ureidoglycolate succinate meso-2,6-diaminopimeloyl- ACP dehydratase carboxylase with a short gly a reduced an N-formyl-L- an N-terminal- a peptidoglycan a peptide with lipid II (meso diaminopimelate containing) ACP dehydratase carrier-protein] precursor with hydrogen Cd 2+ CadA Cd 2+ a 5,10- a uridine 34 ubiquinone-6 a reduced L-methionyl-L- a DNA segment glycine) tetrapeptide FabZ: fabZ FabZ: fabZ reductase: fabG carboxyltransferase a 5' extension 3' extension ethanol gly electron-transfer methionylaminoacyl- peroxide dimer (S. aureus) an N-terminal asp methylenetetrahydrofolate in tRNA thioredoxin threonyl-[protein] DDE-type 3-oxoacyl-ACP subunit beta: flavoprotein tRNA L-methionine bifunctional a (2E)-but-2-enoyl-[acp] ribonuclease D: integrase/ a (2E)-but-2-enoyl-[acp] reductase B7445_RS09060 ribonuclease penicillin- aspartate malonyl-CoA B7445_RS15020 urea degradation I electron transfer thioredoxin- transposase/ alginate RS02135 alginate acyl-CoA/acyl-ACP FabG: fabG P protein acetyl phosphate tRNA uridine-5- peptide type I methionyl binding type I methionyl transaminase/ enoyl-ACP ribonuclease 4-aminobutanoate flavoprotein- dependent recombinase: dehydrogenase: component: carboxymethylaminomethyl(34) deformylase: aminopeptidase: protein aminopeptidase: aspartate 4- reductase a (3R,11Z)-3-hydroxy- ACP S- D: rnd putrescine degradation I degradation III urea ubiquinone thiol B7445_RS15565 B7445_RS11725 rnpA synthesis GTPase MnmE: mnmE B7445_RS03790 map 2: mrdA map decarboxylase: FabI: fabI icos-11-enoyl-[acp] malonyltransferase: urea oxidoreductase: peroxidase: Amino Acid Biosynthesis tRNA uridine-5- [+ 2 isozymes] recombinase B7445_RS13675 alginate RS10190 alginate superpathway of L- superpathway of L-serine [+ 2 isozymes] fabD putrescine 4-aminobutanoate carboxylase: B7445_RS04130 bcp L-histidine biosynthesis L-arginine biosynthesis I (via L-ornithine) L-lysine biosynthesis I superpathway of branched chain amino acid biosynthesis L-alanine L-tryptophan biosynthesis 3-hydroxyacyl- carboxymethylaminomethyl(34) an N-terminal L- a peptidoglycan a DNA segmentRecA: recA ala isoleucine biosynthesis I and glycine biosynthesis I a butanoyl-[acp] acetate putrescine 4-aminobutyrate- uca biosynthesis III a butanoyl-[acp] ACP dehydratase a malonyl-[acp] synthesis enzyme MnmG: mnmG peroxiredoxin: met threonyl-[protein] with D,D cross- D-ala in reverse met a peptide FabZ: fabZ aminotransferase: -2-oxoglutarate urea-1-carboxylate an oxidized a L-methionylaminoacyl- oxaloacetate H + ubiquinol-6 formate B7445_RS11895 link (S. aureus) orientation PRPP glu asp pyruvate gln 3-phospho-D-glycerate beta-ketoacyl- B7445_RS07135 transaminase: electron-transfer tRNA chloride RS15145 chloride bifunctional thr cys chorismate beta-ketoacyl- a (2E,11Z)-icosa- ketoacyl-ACP allophanate phosphoglycerate ACP synthase 4-aminobutanal gabT a 5-carboxymethylaminomethyluridine 34 flavoprotein aspartate ATP aspartate kinase: biosynthetic-type cysteine II: fabF ACP synthase 2,11-dienoyl-[acp] synthase III: an uncharged succinate hydrolase: a 7,8-dihydrofolate an oxidized H O bifunctional threonine dehydrogenase: serA in tRNA 2 transaminase/ phosphoribosyltransferase B7445_RS08065 acetolactate desulfurase: II: fabF B7445_RS09540 tRNA gamma- semialdehyde atzF thioredoxin glutamate N- ammonia-lyase: anthranilate synthase enoyl-ACP aspartate 4- regulatory subunit: synthase: ilvB ilvN B7445_RS02005 3-phosphooxypyruvate a 3-oxohexanoyl-[acp] aminobutyraldehyde chloride RS11460 chloride acetyltransferase/ L-aspartyl-4-phosphate B7445_RS07950 component I: trpE a 3-oxohexanoyl-[acp] reductase decarboxylase: B7445_RS10865 cysteine an acetoacetyl-[acp] dehydrogenase: carbamate amino-acid (S)-2-acetolactate phosphoserine FabI: fabI methylamine B7445_RS13675 desulfurase: 3-oxoacyl-ACP B7445_RS09110 a purine base a mature an N-terminal- an N-terminal- ATP acetyltransferase aspartate- (2Z)-2-aminobut-2-enoate transaminase: 3-oxoacyl-ACP 37 B7445_RS04505 anthranilate PRPP reductase succinate degradation I β-alanine (R)-4- DMAPP an adenosine peptidoglycan aci-nitroethane L-methionyl-L- L-methionyl-L- γ-L-glutamyl- gly L-canavanine phosphoribosyltransferase: ketol-acid a gondoyl-[acp] lesion in DNA (n) asp ArgJ: argJ semialdehyde B7445_RS06705 reductase phosphatidylcholine queuosine biosynthesis I (de novo) 4-aminobutanoate phosphopantoate in tRNA alanyl-[protein] valyl-[protein] D-alanine heme b CcmA heme b B7445_RS07665 dehydrogenase: reductoisomerase: ala FabG: fabG (meso-DAP N-acetyl-L- FabG: fabG biosynthesis VI methylamine 1-(5-phospho- B7445_RS10705 ilvC anthranilate O-phospho-L-serine 3-oxoacyl-[acyl- CO containing) aspartate kinase: 3-oxoacyl-[acyl- methylamine 2 bifunctional DNA- nitronate glutamate carrier-protein] epoxysqualene a CDP- preQ bifunctional tRNA (adenosine(37)-N6) type I methionyl type I methionyl glutathione arginase: B7445_RS08065 β-D-ribosyl)-ATP (2R)-2,3-dihydroxy- phosphoribosyltransferase: trpD choline 0 dehydrogenase formamidopyrimidine monooxygenase: a metal a metal L-aspartate 4- 2-iminobutanoate carrier-protein] biosynthesis diacylglycerol NADPH-dependent 7- -dimethylallyltransferase aminopeptidase: aminopeptidase: synthase: rocF RS03535 phosphoribosyl-ATP acetylglutamate 3-methylbutanoate phosphoserine reductase: fabG light chain: glycosylase/ phosphopantothenoylcysteine lytic murein B7445_RS08070 cation cation semialdehyde reductase: fabG cyano-7-deazaguanine choline degradation I MiaA: miaA map map gshB L-aspartyl- pyrophosphatase: kinase: argB phosphatase SerB: serB a (3R)-3- CDP-diacylglycerol (2E,6E)-farnesyl allantoin degradation B7445_RS07565 DNA-(apurinic decarboxylase/ transglycosylase: dihydroxy-acid N-(5-phosphoribosyl)-anthranilate a (3R)-3- phosphatidylcholine/ reductase QueF: queF [+ 2 isozymes] 4-phosphate B7445_RS01350 4-hydroxy- hydroxyhexanoyl-[acp] biosynthesis I diphosphate to ureidoglycolate formaldehyde or apyrimidinic phosphopantothenate B7445_RS06480 dehydratase: ilvD L-arginine biosynthesis II (acetyl cycle) hydroxyhexanoyl-[acp] presqualene phosphatidylserine preQ 6 urea N-acetylglutamyl- tetrahydrodipicolinate phosphoribosylanthranilate ser 1 I (urea producing) choline site) lyase: mutM synthase: B7445_RS00305 N -(3-methylbut- [+ 7 isozymes] an N-terminal L- an N-terminal L-canaline a metal a metal aspartate- phosphoribosyl- phosphate synthase: 3-hydroxyacyl- DHAP diphosphate synthase: choline 2-en-1-yl)- norophthalmate RS11465 2-oxobutanoate 3-methyl-2-oxobutanoate isomerase: B7445_RS15765 3-hydroxyacyl- tRNA guanosine(34) acetaldehyde nitrite met alanyl-[protein] met L-valyl-[protein] cation cation semialdehyde ATP B7445_RS12080 N-acetylglutamyl- ACP dehydratase glycerol-3- synthase B7445_RS05045 (S)-(+)-allantoin dehydrogenase: adenosine 37 N-acetyl- serine ACP dehydratase (R)-4'- a mature GlcNAc-1,6- dehydrogenase: diphosphatase: (2S,4S)-4- phosphate 1-(2-carboxyphenylamino)-1- FabZ: fabZ phosphate HpnD: hpnD transglycosylase Tgt: tgt allantoinase betA urea degradation II a [DNA]- a 5'-phospho- a modified in tRNA gamma- biosynthetic-type hydroxymethyltransferase: FabZ: fabZ presqualene 4-oxo-2-pentenal phosphopantothenate peptidoglycan anhMurNAc- B7445_RS10705 B7445_RS13605 hydroxy-2,3,4,5- deoxy-D-ribulose 5-phosphate dehydrogenase: PuuE: puuE betaine aldehyde nucleotide- [DNA] nucleobase (n) glutamyl- acetolactate 2-isopropylmalate branched-chain B7445_RS16215 diphosphate a phosphatidylcholine a 7-aminomethyl-7- (meso-DAP L-Ala-γ-D-Glu- a metal a metal 1-(5-phospho-β- tetrahydrodipicolinate N-acetyl- a (2E)-hex-2-enoyl-[acp] B7445_RS04605 34 3'-phosphate RS11470 L-aspartate 4- phosphate synthase: ilvB ilvN synthase: amino acid indole-3-glycerol phosphate a (2E)-hex-2-enoyl-[acp] deazaguanosine in tRNA allantoate urea containing) DAP-D-Ala cation cation D-ribosyl)-AMP 4-hydroxy- gamma- sn-glycerol presqualene betaine-aldehyde semialdehyde reductase: (S)-2-aceto-2- B7445_RS02590 aminotransferase: synthase TrpC: trpC gly tRNA preQ1(34) S- urease: ureC tetrahydrodipicolinate glutamyl- enoyl-ACP acyl-CoA/acyl-ACP 3-phosphate diphosphate dehydrogenase: phosphoribosyl- argC hydroxybutanoate B7445_RS05615 adenosylmethionine B7445_RS08380 homoserine reductase: phosphate reductase dehydrogenase: glycerol-3- synthase betB a peptide with an N-terminal- an N-terminal- AMP N-acetyl-L- (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate ribosyltransferase- B7445_RS08385 a single a 5-L-glutamyl- a ribonucleoside a single a metal a metal dehydrogenase: B7445_RS14510 ketol-acid (2S)-2-isopropylmalate reductase: FabI: fabI B7445_RS11725 phosphate 1-O- HpnD: hpnD an amino acid an N-terminal L-methionyl-L- L-methionyl- met RS03525 cyclohydrolase: glutamate 5- acetylglutamate isomerase QueA: queA glycine betaine ammonium stranded DNA [peptide] ATP triphosphate stranded DNA dGDP cation cation B7445_RS07070 reductoisomerase: val argC acyltransferase (S)-ureidoglycolate a tRNA precursor L-proline seryl-[protein] glycyl-[protein] hisI semialdehyde (S)-2,3,4,5- 3-isopropylmalate kinase: argB : a hexanoyl-[acp] [+ 2 isozymes] squalene CTP bifunctional ribonucleotide- β ilvC PlsY: plsY acyl-CoA hydrolysis an epoxyqueuosine 34 in tRNA L-homoserine 1-(5-phospho- -D-ribosyl)- tetrahydrodipicolinate dehydratase: gln N-acetyl-L-glutamate trpB B7445_RS02750 exodeoxyribonuclease glutamate N- diphosphate 5-[(5-phosphoribosylamino) (R)-2,3-dihydroxy- glu N-acetyl-L-glutamate a hexanoyl-[acp] a 1-acyl-sn gamma- DNA primase: type I methionyl type I methionyl acetyltransferase/ 2,3,4,5- leuC leuD bifunctional 5-semialdehyde beta-ketoacyl- a 2,3,4-saturated tRNA VII large subunit: prolyl reductase: a metal RS04310 a metal methylideneamino]imidazole- 3-methylpentanoate indole ser -glycerol 3- glutamyltransferase: CCA tRNA B7445_RS08025 aminopeptidase: aminopeptidase: amino-acid homoserine tetrahydropyridine- glutamate N- glutamine- ACP synthase fatty acyl CoA epoxyqueuosine(34) B7445_RS04060 aminopeptidase: pip B7445_RS13325 cation cation 4-carboxamide 2-isopropylmaleate ammonia assimilation cycle III beta-ketoacyl- phosphate acyl-CoA B7445_RS12515 nucleotidyltransferase: bifunctional map map acetyltransferase kinase: N-acetyl-L- 2,6-dicarboxylate N- dihydroxy-acid acetyltransferase/ hydrolyzing II: fabF (3S)-2,3- reductase QueG: queG exodeoxyribonuclease B7445_RS13330 1-(5-phosphoribosyl)-5- hydrogencarbonate bifunctional ACP synthase 1-acyl-sn-glycerol- thioesterase: [+ 2 isozymes] B7445_RS00480 DNA primase/ ArgJ: argJ B7445_RS12530 ornithine succinyltransferase: dehydratase: ilvD 3-isopropylmalate amino-acid carbamoyl- tryptophan synthase: epoxy-2,3- VII small subunit: GDP glutamate N- II: fabF 3-phosphate 34 N-acetyl-L- [(5- phosphoribosylamino) dapD phosphate ammonium a 3-oxooctanoyl-[acp] dihydrosqualene B7445_RS06040 a queuosine in tRNA polymerase: an N-terminal an N-terminal a metal a metal O-phospho- acetylornithine glutamine- (3S)-3-methyl-2- dehydratase: acetyltransferase acetyltransferase/ trpB B7445_RS02750 acyltransferase: B7445_RS01960 a tRNA a peptide pro methionine RS15150 methylideneamino]imidazole-4- N-succinyl-2-amino- synthase: type I acyl-CoA an α-(5-L- B7445_RS12720 met L-seryl-[protein] met glycyl-[protein] cation cation L-homoserine deacetylase: hydrolyzing oxopentanoate leuC leuD ArgJ: argJ amino-acid glu a 3-oxooctanoyl-[acp] B7445_RS00375 containing a carboxamide isomerase: hisA 6-ketopimelate carB carA glutamate- 3-oxoacyl-ACP thioesterase: lipoprotein posttranslational modification glutamyl)- a peptide threonine argE carbamoyl- branched-chain acetyltransferase superpathway Inorganic Nutrient Metabolism 3' CCA end phosphoribulosylformimino- (2R,3S)-3-isopropylmalate trp -ammonia reductase 3-oxoacyl-ACP 1-acyl-sn-glycerol- B7445_RS03810 a ribonucleoside a single-stranded amino acid ssDNA/pppN(pN) synthase: acetylornithine phosphate N-succinyldiaminopimelate amino acid ArgJ: argJ of L-threonine glutamate a 2,3,4-saturated AICAR-phosphate carbamoyl phosphate L-ornithine ligase: glnA FabG: fabG reductase 3-phosphate a [prolipoprotein]- 5'-monophosphate oligodeoxyribonucleotide hybrid a metal a metal aminotransferase: aminotransferase: biosynthesis synthase fatty acid n -1 RS06225 B7445_RS10920 deacetylase: synthase: 3-isopropylmalate 2-oxoglutarate 3-oxoacyl-[acyl- acyltransferase: assimilatory cation cation B7445_RS07135 B7445_RS05615 N-acetyl-L-ornithine large type III FabG: fabG L-cysteine thiosulfate oxidation III (multienzyme complex) argE carB carA dehydrogenase: oxaloacetate carrier-protein] B7445_RS05030 sulfate reduction IV assimilatory thr imidazole subunit: gltB glutamate- 3-oxoacyl-[acyl- a 1,2-diacyl- prolipoprotein N-succinyl-L,L-2,6- leuB bifunctional sulfate reduction III 34 3-benzyl-3,6 - β-D-fructofuranose a [lipoyl-carrier glycerol carbamoyl -ammonia reductase: fabG carrier-protein] diacylglyceryl a 5,10- a 2-thiouridine glutathione shikimate urea-1-carboxylate L-ornithine diaminopimelate ile (2S)-2-isopropyl- aspartate sn-glycerol sulfate a [SoxY protein]-L-cysteine hypoglycin A bis(cysteinylglycine) 1-phosphate protein]-N 6 -[(R) asp a metal a metal phosphate L-methionine biosynthesis III ligase: glnT transferase: methylenetetrahydrofolate in tRNA hypoxanthine RS01075 threonine phosphate succinyl- 3-oxosuccinate transaminase/ a (3R)-3- reductase: fabG 3-phosphate sulfate sulfate - 6-(hydroxymethyl) glucose/quinate/ -dihydrolipoyl]- cation cation B7445_RS03055 PRPP bifunctional ammonia-lyase: synthase: diaminopimelate ornithine aspartate 4- Asp-tRNA(Asn) hydroxyoctanoyl-[acp] a (3R)-3- phosphatidate adenylyltransferase sulfate -diketopiperazine shikimate family L-lysinedihydrolipoyl ornithine a [prolipoprotein]- fructose aspartate allophanate B7445_RS07950 hisF hisH desuccinylase: carbamoyltransferase: decarboxylase: ammonium /Glu-tRNA(Gln) gln 3-hydroxyacyl- hydroxyoctanoyl-[acp] cytidylyltransferase: subunit 2: adenylyltransferase tRNA uridine-5- membrane-bound dehydrogenase: carbamoyltransferase: L-homoserine S-1,2-diacyl-sn- gamma- bisphosphate transaminase/ hydrolase: (2Z)-2-aminobut- dapE argF B7445_RS13675 amidotransferase: ACP dehydratase B7445_RS03185 B7445_RS06890 subunit 2: carboxymethylaminomethyl(34) PQQ-dependent B7445_RS02510 D-erythro-1- argF 3-hydroxyacyl- glyceryl-L-cysteine a [SoxY protein]-S- xanthine glutamyltransferase: membrane aldolase: aspartate 4- atzF nitrate RS02130 nitrate 2-enoate homoserine O- gatB gatA gatC FabZ: fabZ a CDP- APS B7445_RS06890 synthesis GTPase MnmE: mnmE dehydrogenase: AICAR (imidazol-4- L-proline 4-methyl-2-oxopentanoate asp ACP dehydratase sulfosulfanyl-L-cysteine phosphoribosyltransferase: gpt B7445_RS12515 dipeptidase: B7445_RS05155 dihydrolipoyl decarboxylase: L,L-diaminopimelate biosynthesis I acetyltransferase: [+ 5 isozymes] diacylglycerol APS tRNA uridine-5- B7445_RS08585 yl)-glycerol FabZ: fabZ signal adenylyl-sulfate [+ 2 isozymes] B7445_RS10555 dehydrogenase: B7445_RS13675 (from L-glutamate) branched-chain B7445_RS01415 a (2E)-oct-2-enoyl-[acp] cytochrome c: carboxymethylaminomethyl(34) a [lipoyl-carrier 3-phosphate asp L-citrulline aspartate kinase: peptidase kinase: cysC phosphoadenylyl- 3-dehydroshikimate lpdA oxaloacetate ammonium CO diaminopimelate amino acid a (2E)-oct-2-enoyl-[acp] II: lspA B7445_RS07570 synthesis enzyme MnmG: mnmG D-glyceraldehyde protein]-N 6 -[(R 2 imidazoleglycerol- B7445_RS08065 O-acetyl-L- enoyl-ACP sulfate reductase: 3-benzyl-3,6 - DHAP 2-iminobutanoate epimerase: glu aminotransferase: hydrogen sulfide [+ 8 isozymes] IMP hypoglycin B L-cysteinylglycine )-lipoyl]-L-lysine phosphate B7445_RS07795 glutamate homoserine glu reductase PAPS B7445_RS06885 bis(cysteinyl)- 6- gly argininosuccinate B7445_RS05615 L-citrulline acyl-CoA/acyl-ACP an (S-diacyl-sn- a lipoprotein a 5-aminomethyl-2- dehydratase 5-kinase: L-aspartyl- FabI: fabI a [SoxY protein]-S- a [SoxY protein]-S a 7,8-dihydrofolate (hydroxymethyl) HisB: hisB synthase: 4-phosphate dehydrogenase: glyceryl)-L-cysteinyl- signal peptide phosphoadenylyl- sulfite thiouridine 34 in tRNA -diketopiperazine meso-diaminopimelate B7445_RS12785 argininosuccinate O-acetylhomoserine disulfanyl-L-cysteine -sulfanyl-L-cysteine 3-(imidazol-4- B7445_RS08475 γ-L-glutamyl leu B7445_RS11725 [apolipoprotein] signal peptide sulfate reductase: synthase: sulfhydrylase: metZ an octanoyl-[acp] yl)-2-oxopropyl 5-phosphate aspartate- [+ 2 isozymes] apolipoprotein N- peptidase B7445_RS06885 2-oxobutanoate phosphate L-arginino- diaminopimelate L-arginine B7445_RS08475 semialdehyde acyltransferase: lnt a supercoiled decarboxylase: lysA glutamate-5- beta-ketoacyl- SppA: sppA sulfite cob(II)inamide 2-methylbutanoate hop-22(29)-ene SAM a uracil in DNA leukotriene-D4 shikimate D-glycerate carbonic acid histidinol- succinate degradation I dehydrogenase: an octanoyl-[acp] an N-acyl-(S-diacyl- ATP duplex DNA biosynthetic- semialdehyde L-arginino-succinate L-homocysteine ACP synthase hydrogen sulfide glucose/quinate/ D-glycerate ATP- phosphate (arginase pathway) B7445_RS10705 II: fabF sn-glyceryl)-L- a peptide type argininosuccinate L-phenylalanine lys dehydrogenase: a [SoxY protein]-S-(2- shikimate family dehydrogenase: dependent acetolactate transaminase: lyase: argH B7445_RS07935 argininosuccinate L-aspartate 4- methionine methionine cysteinyl-[lipoprotein] urea cycle acetate--CoA uracil-DNA membrane carbonic biosynthesis I arg sulfodisulfanyl)-L-cysteine sulfate activation cob(I)yrinic acid a,c-diamide adenosyl- membrane-bound B7445_RS03900 DNA synthase: B7445_RS08930 lyase: argH semialdehyde synthase: synthase: L-cysteine biosynthesis I a 3-oxodecanoyl-[acp] fatty acid elongation -- saturated ligase: acs glycosylase: dipeptidase: anhydrase: L-glutamate-5- for sulfonation adenosyltransferase: cobO hopene PQQ-dependent glyoxylate/ helicase ilvB ilvN L-histidinol chorismate arginase: homoserine metH metH hydrogen sulfide acetate--CoA transferase B7445_RS13155 B7445_RS10555 B7445_RS05730 arg semialdehyde 3-oxoacyl-ACP cob(I)yrinic acid a,c-diamide dehydrogenase: hydroxypyruvate RecG: recG phosphate chorismate rocF arg dehydrogenase: methionine methionine arg polyphosphate ligase: acs HpnH: hpnH uracil-DNA (S)-2-aceto-2- ser reductase an acetoacetyl-[acp] sulfate adenosyltransferase: B7445_RS08585 reductase A: [+ 2 isozymes] mutase: L-ornithine B7445_RS07070 synthase: synthase: 5-oxo-L-proline metabolism metabolism glycosylase: a single hydroxybutanoate histidinol- L-glutamate FabG: fabG sulfate B7445_RS03075 leukotriene-E4 3-dehydroshikimate B7445_RS12585 CO H O B7445_RS06065 uracil degradation ammonium ung gly 2 2 stranded DNA ketol-acid phosphatase: B7445_RS02155 B7445_RS02155 serine O- a [protein] with a [protein] with adenylyltransferase (2S)-2- prephenate biosynthesis III I (reductive) L-homoserine 3-oxoacyl-[acyl- argininosuccinate long chain diphosphate adenosyl hopane met hydroxypyruvate reductoisomerase: hisN (S)-1-pyrroline- acetyltransferase: cysE an N-terminal an N-terminal arginase: polyphosphate subunit 2: methylbutanoyl-CoA AMP alanine met carrier-protein] lyase: argH glutamine- adenosylcobinamide ilvC prephenate 2-oxoglutarate 5-carboxylate uracil homoserine serine O- reductase: fabG L-glutamine L-glutamate rocF B7445_RS06890 triphosphate an apyrimidinic uracil histidinol racemization dihydropyrimidine hydrolyzing APS (R)-2,3-dihydroxy- dehydratase: glutamate pyrroline-5- L-glutamate-5- kinase: acetyltransferase: cysE site in DNA synthase large dehydrogenase: preA a (3R)-3- a 3-oxoacyl-[acp] 3-oxoacyl- carbamoyl- polyphosphate 3-methylpentanoate histidinol B7445_RS12075 carboxylate semialdehyde B7445_RS12530 L-arginino- L-ornithine phosphate ala subunit: gltB reductase: O-acetyl-L-serine hydrogen sulfide hydroxydecanoyl-[acp] [acyl-carrier- succinate kinase 2: ppk2 adenylyl-sulfate dihydroxy-acid dehydrogenase: 3-phenyl-2- 5,6-dihydrouracil O-phospho- synthase: a 2'- DNA with adenine:7,8- N-acetyl-D- alanine glu B7445_RS03035 bifunctional 3-hydroxyacyl- protein] a [protein] with RNA degradosome kinase: cysC D-glycerate N-ethylglycine acetyl-CoA dehydratase: hisD oxopropanoate L-homoserine L-ornithine degradation γ-L-glutamyl carB carA cob(II)alamin deoxyribonucleoside dihydro-8- galactosamine L-quinate racemase: proline dihydropyrimidinase: ACP dehydratase reductase: an N-terminal 5- polyphosphate ATP dGTP [DNA] ilvD bifunctional glycine I (L-proline biosynthesis) 5-phosphate glutathione PAPS 5'-triphosphate oxoguanine mismatch 6-phosphate glucose/quinate/ glyoxylate/ acetyl-CoA histidinal alr pro dehydrogenase/L- hydA threonine cysteine synthase FabZ: fabZ fabG oxo-L-proline carbamoyl kinase: (3S)-3-methyl-2- D-ala aspartate biosynthesis IV glutamate gamma- A: B7445_RS06715 shikimate family hydroxypyruvate carboxylase synthase: beta- 3-oxoacyl- argininosuccinate ornithine phosphate B7445_RS11175 glycine oxopentanoate histidinol transaminase/ semialdehyde cysteine synthase A: cysK cob(I)yrinic acid a,c-diamide DNA polymerase A/G-specific N-acetylglucosamine- membrane-bound reductase A: biotin carboxyl 3-ureidopropanoate B7445_RS10920 L-ornithine a (2E)-dec-2-enoyl-[acp] ketoacyl- ACP synthase: carbamoyltransferase: oxidase branched-chain dehydrogenase: aspartate 4- thr dehydrogenase ornithine adenosyltransferase: III subunit chi: adenine 6-phosphate PQQ-dependent B7445_RS12585 carrier ACP reductase B7445_RS08475 argF dNTP ThiO: thiO amino acid hisD decarboxylase: PutA: putA thr cyclodeaminase: enoyl-ACP long chain B7445_RS03075 B7445_RS14325 glycosylase: deacetylase: nagA dehydrogenase: D-glycerate protein: accB threonine aldolase: synthase FabG: fabG L-citrulline glyphosate triphosphohydrolase: dgt aminotransferase: B7445_RS13675 B7445_RS11790 cys reductase a (3R)-3- 5-oxo-L-proline polyphosphate [+ 10 isozymes] B7445_RS11680 B7445_RS08585 dehydrogenase: [+ 5 isozymes] B7445_RS01675 a 2,3,4-saturatedII: fabF degradation II cob(I)yrinic acid a,c-diamide B7445_RS05615 his glu pro FabI: fabI hydroxyacyl-[acyl- 3-dehydroquinate B7445_RS03900 malonyl-CoA gly fatty acyl-[acp] 5-oxoprolinase adenosyltransferase: cobO D-galactosamine ethylamine glyoxylate phe β carrier protein] acetate -alanine 3-hydroxyacyl- subunit taurine glyphosate triphosphate an apurinic site 6-phosphate hydroxypyruvate ile a decanoyl-[acyl-carrier protein] 2'-deoxyguanosine [DNA] ACP PxpB: pxpB degradation IV adenosylcobalamin adenine within DNA dehydratase triphosphate beta-ketoacyl- glycine FabZ: fabZ glu ACP synthase taurine oxidase taurine II: fabF ThiO: thiO dioxygenase: UDP-N-acetyl-α-D-muramoyl- a 2'- a double 34 di-trans,octa-cis- pyruvate a protein with glutathione L-quinate D-glycerate an adenosine Nucleoside and Nucleotide Biosynthesis tauD L-alanyl-γ-D-glutamyl-L- deoxyribonucleoside asp O-ureido-L- Arg2 a 3-oxododecanoyl-[acp] (aminomethyl) undecaprenyl phosphate [DNA] a disulfide bond stranded DNA in [tRNA ] 2-aminoacetaldehyde glyoxylate lysyl-D-alanyl-D-alanine 5'-triphosphate homoserine glucose/quinate/ D-glycerate DNA Flp pilus enoyl-ACP a trans-2- phosphonate 3-oxoacyl-ACP a 2,3,4-saturated periplasmic disulfide bond formation shikimate family dehydrogenase: topoisomerase assembly superpathway of pyrimidine pyrimidine deoxyribonucleotides reductase enoyl-[acyl- pyruvate, superpathway of guanosine superpathway of xanthine and xanthosine salvage pyrimidine deoxyribonucleotide reductase fatty acyl-[acp] phospho-N- DNA polymerase argininosuccinate membrane-bound B7445_RS03900 (ATP- complex ribonucleotides de novo biosynthesis de novo biosynthesis III FabI: fabI carrier protein] a [DsbB protein] a [DsbA protein] two reduced phosphate glutaredoxin nucleotides de novo biosynthesis I adenosine nucleotides phosphorylation FabG: fabG an electron- acetylmuramoyl- III subunit chi: synthase: PQQ-dependent glyoxylate/ hydrolyzing) ATPase [+ 2 isozymes] with reduced L- carrying a cysteine residues dikinase: 2: grxB de novo biosynthesis I UDP CTP 3-oxoacyl-[acyl- transfer quinone pentapeptide- B7445_RS14325 B7445_RS08475 dehydrogenase: hydroxypyruvate subunit B: gyrB component gln hydrogencarbonate dTMP dCMP cysteine residues disulfide bond in a protein Secondary Metabolite Degradation B7445_RS14700 glutaredoxin xanthosine ribonucleotide- nucleoside dTMP (d)CMP kinase: carrier-protein] transferase: [+ 9 isozymes] 3: grxC B7445_RS08585 reductase A: [+ 3 isozymes] TadA: tadA IMP a negatively an inosine 34 IMP asp diphosphate triphosphate kinase: tmk B7445_RS11480 reductase: fabG enoyl-ACP B7445_RS14630 3-dehydroquinate B7445_RS12585 reductase: hydrolase: reductase anhydromuropeptides recycling I phosphoenol canavaninosuccinate supercoiled DNA in [tRNA Arg2 ] glutamine- dTDP dCDP H + hydroxypyruvate IMP B7445_RS13325 B7445_RS13305 a (3R)-3- FabI: fabI pyruvate diphosphate a protein with hydrolyzing xanthine CDP-diacylglycerol GlcNAc-1,6- undecaprenyl-diphospho-N- UMP AMP [DNA] GSSG dehydrogenase: B7445_RS13330 CDP nucleoside- nucleoside- hydroxydodecanoyl-[acp] phosphatidylserine and reduced L- carbamoyl- adenylosuccinate biosynthesis II anhMurNAc- Carboxylate Degradation acetylmuramoyl-L-alanyl-γ-D- guaB dUDP diphosphate diphosphate 3-hydroxyacyl- phosphatidylethanolamine cysteine residues phosphate synthase: xanthine ribonucleotide- kinase: ndk kinase: ndk biosynthesis I L-Ala-γ-D-Glu- glutamyl-L-lysyl- D-alanyl-D-alanine B7445_RS10870 phosphoribosyltransferase: gpt ACP dehydratase DHAP synthase: XMP nucleoside- diphosphate DAP-D-Ala dTTP dCTP FabZ: fabZ glycerol-3- a CDP-diacylglycerol pyruvate decarboxylation to acetyl CoA I acetate carB carA diphosphate reductase: UDP-N-acetyl-α-D- a [DNA]-3'- a 5'-phospho- a [DNA]-3'- (R)-S- D-sedoheptulose phosphate phosphatidylcholine/ conversion di-trans,octa-cis- NAD + γ glutamine- adenylo-succinate XMP kinase: ndk B7445_RS13325 a (2E)-dodec-2-enoyl-[acp] pyruvate muramoyl-L-alanyl-γ-D- hydroxyl [DNA] hydroxyl a type IV prepilin -L-glutamyl-(S)- gly lactoylglutathione 1,7-bisphosphate B7445_RS13330 dehydrogenase: phosphatidylserine a [pyruvate dehydrogenasedehydrogenase to acetyl-CoA undecaprenyl phosphate 2-aminobutanoate adenosine dADP carbamoyl hydrolyzing GMP dUTP 6 glutamyl-L-lysyl-D-alanine asp B7445_RS04605 synthase: β γ E2 protein] N -lipoyl-L-lysine phosphate adenylosuccinate enoyl-ACP N-acetyl- -D- L-alanyl- -D- complex E1 acetate ribonucleotide- synthase: guaA dUTP dCDP sn-glycerol B7445_RS05045 DsbA family pyruvate NAD- exodeoxyribonuclease fructose adenosine lyase: CMP reductase a 3-sn-phosphatidyl- oxidoreductase: glucosamine-1,6- glutamyl-meso-2,6- component acetate--CoA phospho-N- glutathione lactoylglutathione deaminase: diphosphate diphosphatase: dut nucleoside- adenine and 3-phosphate dependent III: B7445_RS10560 prepilin peptidase: bisphosphate GMP B7445_RS14570 phosphorylation FabI: fabI L-serine B7445_RS11205 anhydro-N-acetyl- diaminopimeloyl- subunit beta: ligase: acs acetylmuramoyl- synthase: lyase: gloA B7445_RS07100 reductase: aspartate diphosphate adenosine glycerol-3- a [DsbB protein] a [DsbA protein] β DNA ligase B7445_RS01275 aldolase: nucleoside triphosphate phosphatidylserine an electron- an intra- -D-muramate D-alanine B7445_RS11145 acetate--CoA pentapeptide- exodeoxyribonuclease gshB B7445_RS13325 carbamoyltransferase pyrophosphohydrolase: kinase: ndk CMP salvage VI phosphate 1-O- carrying a with reduced L- LigA: ligA III: xth prepilin peptidase: B7445_RS05155 catalytic subunit: AMP a dodecanoyl-[acp] decarboxylase: transfer quinol disulfide bond cysteine residues protein disulfide dihydrolipoyl pyruvate ligase: acs transferase: B7445_RS11240 inosine B7445_RS13330 guanylate mazG (d)CMP kinase: acyltransferase ADP B7445_RS08800 dCTP B7445_RS05040 dehydrogenase: dehydrogenase acetyl-CoA B7445_RS14630 glutathione methylglyoxal kinase: gmk B7445_RS11480 adenosine PlsY: plsY γ a 2'- D-erythrose dUMP a 1-acyl-sn an L-1- 1,6-anhydro-N- L-alanyl- -D- lpdA (acetyl- a [DNA]-3'- ophthalmate DHAP adenylate kinase: CDP beta-ketoacyl- [DNA] NMN deoxyribonucleoside 4-phosphate adenosine kinase: -glycerol 3- phosphatidylethanolamine acetyl-β-muramate glutamyl-meso- transferring) undecaprenyl-diphospho-N AMP hydroxyl a cleaved type N-carbamoyl- B7445_RS09210 FAD-dependent nucleoside- ACP synthase dihydrolipoyl UMP 5'-monophosphate a peptide GDP inosine-5'-phosphate biosynthesis I B7445_RS10620 phosphate Pentose Phosphate Pathways N 6 -L-threonylcarbamoyladenosine 37 diaminopimelate E1 component -acetylmuramoyl-L-alanyl-γ- IV prepilin L-aspartate thymidylate diphosphate II: fabF anhydro-N- dehydrogenase: 1-acyl-sn-glycerol- -modified tRNA biosynthesis subunit D-glutamyl-L-lysyl- D-alanine ADP synthase: kinase: ndk AMP laurate acetylmuramic a [pyruvate dehydrogenaseB7445_RS02510 pyruvate a [pyruvate dehydrogenase dihydroorotase: Amine and Polyamine Biosynthesis 6 alpha: pdhA 6 AIR B7445_RS04545 3-phosphate pentose phosphate pathway acid kinase: E2 protein] N - dehydrogenase E2 protein] N -S- D-gluconate B7445_RS04825 ribonucleotide- CTP acyl--CoA ligase: acyltransferase: dihydrolipoyl-L-lysine acetyldihydrolipoyl-L-lysine 6 nucleoside- ribonucleotide- a 3-oxotetradecanoyl-[acp] thr B7445_RS04920 complex degradation an N -L- (1S,2R)-1- N-acetyl-muramoyl-(L- a ribonucleoside D-sedoheptulose (3R,5S)-3- dihydroorotase: dTMP spermidine biosynthesis III N-acetylglucosamine a sulfurated 37 a proteinogenic diphosphate diphosphate diphosphate 5-(carboxyamino) spermidine biosynthesis I putrescine B7445_RS11585 B7445_RS00375 D-glucopyranose threonylcarbamoyl- N-acetyl-D- dihydrolipoamide threonylcarbamoyladenine leukotriene-C4 ser C-(indol-3- alanyl-γ-D-glutamyl-L- canavaninosuccinate 1-phosphate hydroxy-1- a protein pyrC degradation I [sulfur carrier] amino acid diphosphate kinase: ndk reductase: reductase: imidazole ribonucleotide biosynthesis I 3-oxoacyl-ACP 1-acyl-sn-glycerol- 6-phosphate AMP synthase: muramate 6- acetyltransferase: D-gluconate in tRNA yl)glycerol lysyl-D-alanyl-D-alanine) ribonucleotide- pyrroline-5- dTMP kinase: tmk lauroyl-CoA ATP- B7445_RS13325 B7445_RS13325 synthase: B7445_RS06330 reductase 3-phosphate glucose-6- B7445_RS14350 phosphate N-acetyl-D- B7445_RS12920 gluconokinase: 3-phosphate diphosphate carboxylatepyrroline-5- (S)-dihydroorotate B7445_RS13330 SAM arg (L-threonylcarbamoyl) N-acetylmuramic glucosamine fructose dependent B7445_RS13330 dTDP SAM FabG: fabG acyltransferase: phosphate B7445_RS04100 gamma- penicillin- argininosuccinate reductase: carboxylate N5-CAIR arg adenylate acid 6-phosphate 6-phosphate D-gluconate tRNA (N(6)-L- tryptophan bisphosphate protease quinone- GTP 3-oxoacyl-[acyl- B7445_RS05030 dehydrogenase: N-acetylglucosamine- threonylcarbamoyladenosine(37) glutamyltransferase: binding lyase: argH B7445_RS13325 reductase: subunit nucleoside- adenosylmethionine a 1,2-diacyl- zwf tRNA (adenosine(37)-N6)- etherase: 6-phosphate 6-phosphate synthase: trpB aldolase: dependent dADP 5-(carboxyamino)imidazole adenosylmethionine carrier-protein] -C(2))- methylthiotransferase B7445_RS12515 protein a 2'- B7445_RS13330 B7445_RS03035 HslV: hslV diphosphate decarboxylase: speD sn-glycerol 6-phospho threonylcarbamoyltransferase B7445_RS06300 deacetylase: nagA B7445_RS02750 B7445_RS05155 dihydroorotate dGDP ribonucleotide mutase: purE 5-aminoimidazole ribonucleotide biosynthesis I decarboxylase: speD reductase: fabG D-glucosamine acetyl-CoA MtaB: mtaB [+ 2 isozymes] 2: mrdA deoxyribonucleoside Hyp kinase: ndk agmatine 3-phosphate D-glucono- complex dimerization N-acetyl-D- a peptide dehydrogenase: nucleoside- dAdoMet agmatine 6-phosphate L-canavanine fumarate 5'-diphosphate asp dTTP putrescine dAdoMet a (3R)-3- phosphatidate 1,5-lactone subunit type 1 TsaB: tsaB glucosamine D-glyceraldehyde B7445_RS09160 nucleoside- diphosphate CAIR agmatinase: 6 D-erythrose PRPP hydroxytetradecanoyl-[acp] cytidylyltransferase: [+ 2 isozymes] 6-phosphate a 2-methylsulfanyl-N -L- an α-(γ-L-glutamyl) 3-phosphate trp N-acetyl-muramoyl-(L- DHAP PRPP diphosphate kinase: ndk speB stearate biosynthesis 6-phosphogluconolactonase: 6 37 5'-deoxyadenosine an unsulfurated leukotriene-D4 alanyl-γ-D-glutamyl- orotate polyamine 3-hydroxyacyl- B7445_RS03185 an N -L- N-acetylglucosamine- threonylcarbamoyladenine met -L-amino acid D-ala kinase: ndk [+ 2 isozymes] II (bacteria and plants) pgl 37 [sulfur carrier] phosphoribosylaminoimidazolesuccinocarboxamide amidophosphoribosyltransferase: polyamine ACP dehydratase threonylcarbamoyladenine 6-phosphate α-D-glucosamine in tRNA L-lysyl-D-alanine) dATP aminopropyltransferase: a CDP- orotate synthase: B7445_RS14560 B7445_RS01340 aminopropyltransferase: FabZ: fabZ D-gluconate in tRNA deacetylase: nagA 6-phosphate dGTP speE putrescine diacylglycerol phosphoribosyltransferase: 5-phospho-β- speE a palmitoyl-[acp] 6-phosphate D-glucosamine gly beta-ketoacyl- a nascent peptidoglycan a [protein chain adenine 2030 an organic 6-O-trans- 1 decarboxylating 6- a proteinogenic B7445_RS06125 SAICAR D-ribosylamine N -(3-aminopropyl) a (2E)-tetradec-2-enoyl-[acp] 6-phosphate (meso-DAP containing) glutathione (R)-β-lysine elongation factor hydroperoxide methoxy-mycolyl- 5-MTR-1-P ACP synthase phosphogluconate amino acid ATP in 23S rRNA 2'-deoxyadenosine agmatine spermidine phosphoglucosamine P]-L-lysine 34 23S rRNA thioredoxin- trehalose 6- enoyl-ACP II: fabF N-end rule pathway I (prokaryotic) 4'-phosphopantetheine S-methyl-5- orotidine 5'- adenylosuccinate phosphoribosylamine- a 3-oxooctadecanoyl- dehydrogenase: gnd mutase: F6P (adenine(2030)-N(6) dependent phosphate reductase lytic murein adenosine trehalose- thioribose-1- phosphate lyase: B7445_RS14570 -glycine ligase: purD [acp] D-ribulose B7445_RS02435 )-methyltransferase thiol guanine and guanosine salvage FabI: fabI leucyl/phenylalanyl- transglycosylase: gamma- EF-P lysine deaminase: phosphatase: phosphate superpathway of pyrimidine 5-phosphate α pantetheine-phosphate RlmJ: peroxidase: guanine and guanosine salvage II 3-oxoacyl- tRNA--protein -D-glucosamine B7445_RS06480 glutamyltransferase: aminoacylase B7445_RS07100 otsB isomerase: orotidine-5'- nucleobases salvage AICAR adenylyltransferase: B7445_RS04610 bcp trehalose- GAR spermidine a myristoyl-[acp] ACP transferase: 1-phosphate B7445_RS12515 GenX: genX an N 6 - S-methyl-5-mtnA phosphate ribulose-phosphate ribose-5- a [protein] [+ 7 isozymes] coaD trans-methoxy- guanosine reductase B7445_RS03895 β 2030 2'-deoxyinosine peroxiredoxin: decarboxylase: uracil bifunctional 3-epimerase: an N-terminal N-terminal L- bifunctional UDP-N- oleate -oxidation Fatty Acid and Lipid Degradation [+ 2 isozymes] methyladenine mono-mycolate thio-D-ribulose phosphoribosylglycinamide FabG: fabG phosphate glycerol B7445_RS11895 pyrF uracil phosphoribosylaminoimidazolecarboxamide guanosine beta-ketoacyl- B7445_RS00555 arginyl-[protein] leucyl-L-arginine acetylglucosamine a mature peptidoglycan a nascent peptidoglycan [a protein chain in 23S rRNA 1-phosphate formyltransferase: isomerase degradation I phosphoribosyltransferase: upp formyltransferase/IMP cyclohydrolase: purH ACP synthase 3-oxoacyl- diphosphorylase/ with (L-alanyl-γ-D-glutamyl- (meso-DAP containing) α γ elongation factor an alcohol UMP B7445_RS11160 RpiA: rpiA oleate an -( -L-glutamyl) 3'-dephospho-CoA UMP II: fabF [acyl-carrier- glucosamine-1- meso-2,6-diaminopimeloyl- with GlcNAc terminus L-cysteinylglycine EF-P]-N-(β-L- guanine FAICAR D-xylulose leucyl/phenylalanyl- glycerol -L-amino acid UMP kinase: FGAR protein] phosphate N- lysyl)-L-lysine 34 UMP kinase: 5-phosphate D-ribose 5- tRNA--protein acyl--CoA ligase: D-alanine) tetrapeptide B7445_RS03170 a 3-oxohexadecanoyl-[acp] reductase: acetyltransferase B7445_RS03170 bifunctional guanine phosphate transferase: B7445_RS11585 phosphoribosylformylglycinamidine fabG GlmU: glmU UDP UDP xanthine phosphoribosylaminoimidazolecarboxamide 3-oxoacyl-ACP biotin-carboxyl carrier B7445_RS03895 a [protein] glycerol a [2-oxoglutarate- a 1-acyl-2- a ribonucleoside an [amino-group carrier an unstable synthase: purL purQ purS a (3R)-3- transketolase: an N-terminal N-acetyl-α-D- oleoyl-CoA a sulfurated 2-oxoglutarate N 1 -methyladenine 2-oxoglutarate 1-methyl-dAMP phosphoribosyltransferase: gpt formyltransferase/IMP cyclohydrolase: purH xanthine reductase protein assembly N-terminal L- SAM dehydrogenase arachidonoyl- 2',3'-cyclic protein]-C-terminal-γ- glu ala L-threonine 3- RecA filament- nucleoside- nucleoside- hydroxyoctadecanoyl- B7445_RS02065 L-lysyl-[protein] glucosamine glycerol [sulfur carrier] phosphoribosyltransferase: gpt FabG: fabG a [biotin carboxyl- leucyl-L-lysine E2 protein] N 6 - sn-glycerol phosphate (L-glutamyl)-L-glutamate O-phosphate DNA complex diphosphate diphosphate kinase: ndk FGAM [acp] transketolase: tkt 1-phosphate acyl-CoA/acyl-ACP kinase bifunctional 2',3'- threonine- DNA IMP carrier protein]-L-lysine octanoyl-L-lysine 3-phosphate CTP acetylglutamate kinase: ndk GMP 3-oxoacyl-[acyl- 3-hydroxyacyl- dehydrogenase: GlpK: glpK DNA oxidative DNA oxidative cyclic-nucleotide 2'- phosphate repair gln UTP phosphoribosylformylglycinamidine D-sedoheptulose D-glyceraldehyde bifunctional UDP-N- kinase: argB glutamate-- carrier-protein] ACP biotin--[acetyl- B7445_RS11725 demethylase demethylase phosphodiesterase/ decarboxylase: protein UTP CTP synthase: GMP cyclo-ligase: B7445_RS11165 7-phosphate 3-phosphate acetylglucosamine sn-glycerol lipoyl cysteine ligase: reductase: fabG dehydratase CoA-carboxylase] acyl-CoA/acyl-ACP AlkB: alkB AlkB: alkB phosphatidate 3'-nucleotidase: an [amino-group carrier (R)-1-amino-B7445_RS14395 RecO: B7445_RS04810 diphosphorylase/ 3-phosphate synthase: cytidylyltransferase: B7445_RS10490 recO a (3R)-3- FabZ: fabZ ligase: bifunctional dehydrogenase: B7445_RS10485 protein]-C-terminal- 2-propanol O a stabilized CTP synthase: AIR glucosamine-1- lipA B7445_RS03185 a ribonucleoside γ CTP hydroxyhexadecanoyl-[acp] a (2E)-octadec- B7445_RS04290 transaldolase/ B7445_RS01055 glycerol-3- -(5-phospho-L- -2-phosphate RecA filament- B7445_RS04810 a [biotin carboxyl- phosphate N- 3'-phosphate 2-enoyl-[acp] phosoglucose (2E,9Z)- phosphate a [2-oxoglutarate formaldehyde succinate formaldehyde succinate glutamyl)-L-glutamate γ-L-glutamyl- DNA complex 3-hydroxyacyl- carrier protein]-N acetyltransferase 5'-deoxyadenosine an unsulfurated adenine dAMP CTP isomerase: octadecenoyl-CoA dehydrogenase: met dehydrogenase a CDP-1-acyl- D-alanine ACP dehydratase enoyl-ACP 6 GlmU: glmU [sulfur carrier] -biotinyl-L-lysine glpD E2 protein] N 6 2-arachidonoyl- FabZ: fabZ reductase B7445_RS04075 UDP-N-acetyl- -lipoyl-L-lysine glycerol FabI: fabI α-D-glucosamine DHAP a (2E)-hexadec-2-enoyl-[acp] D-erythrose UDP-N-acetylglucosamine a [biotin carboxyl- F6P (S)-3-hydroxy-(9Z) a stearoyl-[acp] 4-phosphate 2503 adenosine 1-carboxyvinyltransferase: -octadecenoyl-CoA adenine an acyl-[acyl- 3'-dephospho- a [protein]-L- L(or D)-O- a mismatched enoyl-ACP carrier-protein dimer]- transketolase: DL-allothreonine 2',3'-cyclic ω aminomalonate 6 murA in 23S rRNA ATP CoA proline ( = 180) DNA base pair reductase N -biotinyl-L-lysine carrier protein] bifunctional phosphoserine B7445_RS02065 UDP-N-acetyl-α- monophosphatebifunctional 2',3'- FKBP-type DNA FabI: fabI acetyl-CoA (Kdo) -lipid A peptidyl-prolyl cis- aspartate phosphoserine mismatch 2 transketolase: tkt D-glucosamine- cyclic-nucleotide 2'- carboxylase biosynthesis I (E. coli) 23S rRNA trans isomerase: transaminase/ phosphatase repair D-glyceraldehyde enolpyruvate 3-oxo-(9Z)- (adenine(2503)-C(2) phosphate serine phosphodiesterase/ a palmitoyl-[acp] stearate biotin α α dephospho- B7445_RS08470 aspartate 4- SerB: serB protein acetyl-CoA -Kdo-(2->4)- -Kdo- 3-phosphate UDP-N- octadecenoyl-CoA )-methyltransferase acyltransferase hydroxymethyltransferase: 3'-nucleotidase: carboxylase (2->6)-lipid IV (E. coli) PlsX: plsX B7445_RS16215 CoA kinase: [+ 5 isozymes] decarboxylase: MutS: mutS carboxylase A acetylmuramate B7445_RS10485 serine a properly acyl--CoA ligase: subunit: accC lauroyl RlmN: rlmN B7445_RS06995 a [protein]-L- B7445_RS13675 carboxyltransferase acyltransferase: 2-oxoglutarate decarboxylation to succinyl-CoA Respiration dehydrogenase: 3'-AMP ω matched B7445_RS11585 acetyl-CoA proline ( = 0) subunit beta: B7445_RS08625 murB gly DNA base pair carboxylase α-Kdo-(2->4)-α-Kdo-(2-> a [2-oxoglutarate a 2-methyladenine 2503 an acyl phosphate acetaldehyde B7445_RS09060 UDP-N-acetyl- (7Z)-hexadecenoyl-CoA 5'-deoxyadenosine acyl-carrier protein gly + palmitate stearoyl-CoA biotin 6)-(lauroyl)-lipid IV (E. coli) in 23S rRNA met ADP coenzyme A H A dehydrogenase α-D-muramate carboxylase lipid A biosynthesis 6 acyl--CoA ligase: E2 protein] N 2-oxoglutarate acyl-CoA/acyl-ACP a purine RS14125 a purine subunit: accC acyltransferase: UDP-N- B7445_RS11585 -lipoyl-L-lysine dehydrogenase dehydrogenase: acetylmuramate:L- β 4 38- a [carboxyl-carrier B7445_RS03785 2-oxoglutarate E1 component: B7445_RS11725 galactosyl-(glucosyl) ADP-L-glycero- - a [protein]- an O - a peptidoglycan guanosine a uridine a [protein]-L- 6 α α alanyl-γ-D- 2-oxoglutarate 1-methyl-dATP protein dimer]-N - -D-Kdo-(2->4)- -D- dehydrogenase B7445_RS02500 acyl-CoA/acyl-ACP -(heptosyl) -Kdo - D-manno-heptose methylthymine dimer (generic) 2',3'-cyclic 40 in tRNA sarcosine repressor LexA methionine palmitoyl-CoA glutamyl-meso- 3 3 2 L-cysteine 2+ 2+ carboxybiotinyl-L-lysine Kdo-(2->6)-lipid A (E. coli) E1 component: dehydrogenase: lipid A-bisphosphate in DNA monophosphate RluA family peptide- Co Co diaminopimelate bifunctional 2',3'- transcriptional 2+ RS03340 2+ pseudouridine methionine Ni Ni B7445_RS02500 B7445_RS01055 DNA oxidative lytic murein cyclic-nucleotide 2'- ligase: methylated-DNA-- synthase: repressor (S)-S-oxide [+ 2 isozymes]a [2-oxoglutarate a [2-oxoglutarate (2E,7Z)- autotransporter demethylase transglycosylase: phosphodiesterase/ B7445_RS14650 [protein]-cysteine S- B7445_RS08555 glycine oxidase LexA: lexA reductase Cofactor, Carrier, and Vitamin Biosynthesis dehydrogenase dehydrogenase hexadecenoyl-CoA strand-loop-strand O- AlkB: alkB B7445_RS06480 3'-nucleotidase: cob(II)yrinate a,c- superpathway of heme b superpathway of tetrahydrofolate biosynthesis methyltransferase: ThiO: thiO cleaved MsrA: msrA [2Fe-2S] iron-sulfur cob(II)yrinate a,c-diamide ubiquinol-8 biosynthesis flavin biosynthesis I (bacteria and plants) lipoate biosynthesis glutathione E2 protein] N 6 E2 protein] N 6 -S- UDP-N-acetyl- heptosyltransferase: B7445_RS10485 [+ 2 isozymes] a protein-L- diamide biosynthesis I [+ 7 isozymes] a pseudouridine 38- cluster biosynthesis (early decarboxylation) and incorporation I biosynthesis biosynthesis from glutamate α-D-muramoyl- B7445_RS01835 repressor LexA (early cobalt insertion) biosynthesis II (late -dihydrolipoyl- succinyldihydrolipoyl- B7445_RS03835 3'-GMP 40 in tRNA methionine- cobalt incorporation) all-trans- L-lysine L-lysine L-alanyl-γ-D- formaldehyde succinate (S)-S-oxide uroporphyrinogen-III GlcNAc-1,6- glyoxylate methylamine L-cysteine desulfurase octaprenyl GTP an octanoyl-[acp] cys glu glu GTP glutamyl-meso-2,6- (S)-3-hydroxy-(7Z) core oligosaccharide-lipid a [protein]-S- dATP a lipid II uroporphyrinogen-III uroporphyrinogen-III 4-hydroxybenzoate Glycolysis a thymine in DNA anhydro-MurNAc- diphosphate lipoyl(octanoyl) glutamate-- diaminopimelate -hexadecenoyl-CoA ADP A (E. coli K-12 core type) methyl-L-cysteine C-methyltransferase: uroporphyrinogen-III pentapeptide cysteine transferase tRNA ligase: GTP Secondary Metabolite Biosynthesis cobA C-methyltransferase: bifunctional glycolysis III (from glucose) 2-oxoglutarate desulfurase: 4-hydroxybenzoate LipB: lipB glutamate-- B7445_RS06660 cyclohydrolase precorrin-1 cobA 3,4-dihydroxy- a [lipoyl-carrier protein] dehydrogenase 6 B7445_RS02005 octaprenyltransferase: cysteine ligase: I FolE: folE an O - all-trans- 2251 S-methyl-5- 6-O-cis-methoxy- precorrin-1 2-butanone- N 6 -octanoyl-L-lysine glutamate-- methylerythritol phosphate pathway I E1 component: 3-oxo-(7Z)- an N-terminal an L-phenylalanyl- a [protein]- carbamoyl guanosine cysteine ubiA B7445_RS10490 7,8- D-glucopyranose Alcohol Degradation methylguanine hexaprenyl L-ornithine thio-D-ribulose 3'-AMP mycolyl-trehalose 3',5'-ADP uroporphyrinogen-III 4-phosphate tRNA ligase: B7445_RS02500 hexadecenoyl-CoA arginyl-[protein] [tRNA Phe ] L-cysteine 4-aminobenzoate phosphate in 23S rRNA desulfurase: uroporphyrinogen-III lipoyl B7445_RS08795 dihydroneopterin preQ biosynthesis in DNA diphosphate 23S rRNA 1-phosphatemethylthioribulose bifunctional 2',3'- 6-phosphate 3'(2'),5'- C-methyltransferase: synthase/GTP an L-glutamyl- D-glyceraldehyde 0 trehalose- B7445_RS04505 C-methyltransferase: 4-hydroxy-3- synthase: lipA γ-L-glutamyl- 3'-triphosphate pyruvate glucokinase: 2-oxoglutarate ethanol (guanosine(2251) cyclic-nucleotide 2'- bisphosphate cobA cyclohydrolase II: Glu 3-phosphate 1-phosphate a [lipoyl-carrier L-cysteine [tRNA ] B7445_RS01215 dehydrogenase leucyl/phenylalanyl- methylated-DNA-- -2'-O)- phosphatase: cobA octaprenylbenzoate B7445_RS02880 degradation II 4-hydroxybenzoate ornithine dehydratase: phosphodiesterase/ nucleotidase an S-sulfanyl-[L- 6 complex otsB precorrin-2 2,5-diamino-6- protein]-N -[(R)- glutathione GTP D-glucopyranose tRNA--protein [protein]-cysteine S- octaprenyltransferase: carbamoyltransferase: methyltransferase 5-(methylsulfanyl)B7445_RS09390 3'-nucleotidase: trehalose- CysQ: cysQ cysteine desulfurase] precorrin-2 dihydrolipoyl]-L-lysine 1-deoxy-D-xylulose- dihydrolipoyllysine- ethanol (5Z)-tetradecenoyl-CoA transferase: methyltransferase: RlmB: rlmB (5-phospho-D- synthase: 7,8- GTP 6-phosphate ubiA argF 2-O- -2,3-dioxopentyl B7445_RS10485 cis-methoxy- precorrin-2 5-phosphate residue alcohol B7445_RS03895 B7445_RS01835 AMP ribosylamino) gshB dihydroneopterin 2251 mono-mycolate dehydrogenase: precorrin-2 C(20)- (S)-4-amino-5- synthase: cyclohydrolase bifunctional succinyltransferase: acyl-CoA/acyl-ACP methylguanosine 1-phosphate pyrimidin- 3'-phosphate 7,8- dehydrogenase adenosine cobA methyltransferase: 2-octaprenylphenol glutathione oxopentanoate B7445_RS16220 I FolE: folE transaldolase/ odhB dehydrogenase: 3-all trans- in 23S rRNA B7445_RS02565 4(3H)-one dihydroneopterin phosoglucose AdhP: adhP L-phenylalanyl-L- a [protein]-S- hexaprenyl-4- an S-sulfanyl-[cysteine B7445_RS01055 Phe a guanine in DNA L-citrulline 2-octaprenylphenol bifunctional 3'-triphosphate acetaldehyde arginyl-[protein] a tRNA methyl-L-cysteine sirohydrochlorin desulfurase]-[disordered- 1-deoxy-D-xylulose isomerase: acyl-CoA/acyl-ACP aminobenzoate precorrin-3A 6-hydroxylase: ubiM diaminohydroxyphosphoribosylaminopyrimidine 6-carboxytetrahydropterin B7445_RS04075 form scaffold D-erythro-7,8- chorismate 5-phosphate acetaldehyde dehydrogenase: 3-(all-trans deaminase/5-amino-6-(5-phosphoribosylamino) synthase: B7445_RS15735 protein] complex precorrin- dihydroneopterin 1-deoxy-D-xylulose- 2-oxoisovalerate decarboxylation to isobutanoyl-CoA dehydrogenase: B7445_RS11725 [cysteine desulfurase]-S- uracil reductase RibD: ribD 5-aminolevulinate F6P 34 a peptide with 6-O-trans-keto- a protein-L- 3B -octaprenyl) superpathway of thiamine diphosphate biosynthesis II aminodeoxychorismate/ 5-phosphate 6-carboxy-5,6,7,8- adhP an N-terminal an L-phenylalanyl- a [protein]-S- a uridine a ribonucleoside sulfanylcysteine:[acceptor 5-amino-6-(5- dihydroneopterin (2E,5Z)- glycyl-glycine glutathione an N-terminal [DNA] 3'-GMP mycolyl-trehalose methionine- cobalt- benzene-1,2-diol anthranilate synthase an [apo BCAA L-lysyl-[protein] Phe sulfanyl-L-cysteine in tRNA 3'-phosphate synthase: phospho-D- porphobilinogen reductoisomerase: tetrahydropterin tetradecenoyl-CoA [tRNA ] DNA polymerase sirohydrochlorin protein]-cysteine bifunctional 2- aldolase: folB component II: dehydrogenase acetate Xaa-L-proline bifunctional 2',3'- bifunctional 2',3'- 6-phosphate (R)-S-oxidepeptide- cobG D-ribulose ribosylamino)uracil cys synthase: hemB B7445_RS03190 7-carboxy-7- III subunit chi: trehalose- sulfurtransferase: polyprenyl-6- 6-(hydroxymethyl) B7445_RS12895 E2 protein] N 6 cyclic-nucleotide 2'- cyclic-nucleotide 2'- methionine bifunctional deazaguanine β alpha-ketoacid acetate--CoA gamma- tRNA 2- phosphatase: B7445_RS04505 precorrin-3B hydroxyphenol 5-phosphate -D-fructose 1,6- -lipoyl-L-lysine leucyl/phenylalanyl- leucyl phosphodiesterase/ B7445_RS14325 phosphodiesterase/ a [cysteine desulfurase]- diaminohydroxyphosphoribosylaminopyrimidine cysteine porphobilinogen -7,8-dihydropterin 4-amino-4- MEP synthase: queE dehydrogenase ligase: acs glutamyltransferase: thiouridine(34) otsB (R)-S-oxide methylase/3- bifunctional a [ThiS sulfur- bisphosphate dihydrolipoyl tRNA--protein aminopeptidase: 3'-nucleotidase: a 2'- [+ 4 isozymes] 3'-nucleotidase: trehalose- reductase S-sulfanyl-[disordered- precorrin-3B C(17)- deaminase/5-amino-6-(5-phosphoribosylamino) desulfurase: carrier protein] 2-amino-4-hydroxy-6- deoxychorismate 7-carboxy-7- subunit beta: acetate--CoA (3E,5Z)-tetradeca- (S)-3-hydroxy-(5Z) transferase: B7445_RS12515 synthase cobalt-factor III form scaffold demethylubiquinol 3- 3,4-dihydroxy- hydroxymethylbilane hydroxymethyldihydropteridine bifunctional 2-C- dehydrogenase: B7445_RS01650 MnmA: mnmA B7445_RS14330 B7445_RS10485 deoxyribonucleoside B7445_RS10485 trans-keto- MsrB: msrB methyltransferase: uracil reductase RibD: ribD B7445_RS02005 deazaguanine ligase: acs 3,5-dienoyl-CoA -tetradecenoyl-CoA B7445_RS03895 [+ 2 isozymes] a [protein]-L- protein] complex O-methyltransferase 2-butanone- 5-amino-6-(5- synthase: hemC diphosphokinase: folK superpathway of adenosylcobalamin salvage from cobinamide I methyl-D-erythritol fructose lpdA a ribonucleoside 5'-monophosphate mono-mycolate cobJ cysteine 7-cyano-7- guanosine methionine cysteine UbiG: ubiG 4-phosphate phospho-D- (7,8-dihydropterin- 4-phosphate bisphosphate dihydrolipoyl acetyl-CoA acyl-CoA a peptide with desulfurase: deazaguanine γ 34 a proteinogenic desulfurase: 2-methoxy- synthase/GTP preuroporphyrinogen 6-yl)methyl cytidylyltransferase/ aldolase: dehydrogenase: thioesterase: L-phenylalanyl- -L-glutamyl- a [protein]- a 2-thiouridine an N-terminal precorrin-4 ribitylamino)uracil a carboxy- 4-aminobenzoate cob(II)inamide Phe L-cysteinylglycine B7445_RS02005 6-(all-trans- cyclohydrolase II: B7445_RS04505 2-C-methyl-D- synthase B7445_RS05155 B7445_RS02510an [apo BCAA B7445_RS06040 L-lysyl-[protein] a tRNA glycylglycine L-cysteine in tRNA amino acid an [L-cysteine adenylated- uroporphyrinogen- diphosphate an [apo BCAA dehydrogenase 3-oxo-(5Z)- L-proline cobalt-precorrin-3 precorrin-4 C(11)- octaprenyl)phenol B7445_RS02880 erythritol 2,4- QueC: queC dehydrogenase acyl-CoA cysteine desulfurase]-S- [ThiS sulfur- cob(I)yrinic acid a,c-diamide E2 protein] N 6 -S-[2- tetradecenoyl-CoA methyltransferase: 2-octaprenyl-6- 1-deoxy-L- III synthase: dihydropteroate E2 protein] N 6 desulfurase: sulfanyl-L-cysteine carrier protein] adenosyltransferase: cyclodiphosphate preQ triose-phosphate methylpropanoyl]dihydrolipoyl- thioesterase: methoxyphenol 4- B7445_RS09865 0 -dihydrolipoyl- a thiocarboxylated B7445_RS04505 cobM glycero-tetrulose ARP synthase: folP B7445_RS03075 synthase: isomerase: B7445_RS03810 5-methoxy-6- a uridine 34 N-(4-oxoglutaryl)- a [release factor]- an L-aspartyl- a nucleoside cytidine an S-sulfanyl-[cysteine hydroxylase: ubiM L-lysine L-lysine NaMN [SAMP] C- a peptide with a Ins(1)P 4-phosphate uroporphyrinogen-III B7445_RS10480 (3E,5Z)- methylbenzimidazole in tRNA L-cysteinylglycine L-glutamine Asn desulfurase]-S- precorrin-5 2-methoxy-6-all cysteine cob(I)yrinic acid a,c-diamide B7445_RS04795D-glyceraldehyde leader sequence [tRNA ] triphosphate nucleoside D-glyceraldehyde 7,8- 4-(cytidine 5'- DHAP tetradecadienoate (3Z)-dodec- terminal glycine peptide chain Asp-tRNA(Asn) inositol nucleoside cobalt-precorrin-4 sulfanyl-[disordered- trans-octaprenyl- 6,7-dimethyl-8- desulfurase: uroporphyrinogen adenosyltransferase: cobO 3-phosphate release factor deaminase: precorrin- 3-phosphate dihydropteroate diphospho)-2-C- 3-enoyl-CoA /Glu-tRNA(Gln) monophosphatase: triphosphate form scaffold 1,4-benzoquinol ribityllumazine B7445_RS02005 decarboxylase: type I nicotinate-nucleotide-- tRNA 2- deaminated N(5)-glutamine B7445_RS04575 cobalt precorrin- 6A synthase 2-octaprenyl- gly 1-deoxy-D-xylulose- bifunctional [corrinoid adenosyltranferase]-cob(II)inamide methyl-D-erythritol dihydrolipoyllysine- dimethylbenzimidazole glutathione signal amidotransferase: B7445_RS09515 hydrolase: protein] complex synthase: cysteine B7445_RS07245 4-(cytidine 5'- myo-inositol glyceraldehyde- thiouridine(34) peptidase methyltransferase: B7445_RS13305 cytidine 4 (C 11 )- [cysteine desulfurase]-S- (deacetylating): 6-methoxy-1,4- 5-phosphate folylpolyglutamate residue (2- phosphoribosyltransferase: amidase: gatB gatA gatC inositol B7445_RS02885 desulfurase: glycine diphospho)- biosynthesis 3-phosphate synthase I: lepB prmC an L-asparaginyl- a nucleoside deaminase: methyltransferase: sulfanylcysteine:[acceptor B7445_RS02535 benzoquinol synthase: synthase/ methylpropanoyl) cobT B7445_RS15705 5 monophosphatase: B7445_RS04505 coproporphyrinogen III dehydrogenase: (2E)-dodec- MnmA: mnmA a [release factor]-N [tRNA Asn ] diphosphate B7445_RS11400 protein]-cysteine methylase: oxidase dihydrofolate 2-C-methyl-D- D-glucopyranose B7445_RS05640 cobM 6,7-dimethyl-8-(1- B7445_RS16220 gap transferase: 2-enoyl-CoA -methyl-L-glutamine uridine sulfurtransferase: precorrin-6A B7445_RS00310 a thiocarboxylated- ThiO: thiO 1-deoxy-D- oxygen-dependent synthase: erythritol kinase: 6-phosphate B7445_RS02510 myo-inositol cobalt- D-ribityl)lumazine [corrinoid adenosyltranferase]-cob(I)inamide 5-methoxy-6- 34 B7445_RS04505 6-methoxy-3- coproporphyrinogen B7445_RS09065 B7445_RS13195 a [SAMP] C- a 2-thiouridine a leader sequence a peptide precorrin-5A a [cysteine precorrin-6A [ThiS sulfur- 2-iminoacetate xylulose 5- 13-DPG methylbenzimidazole nicotinate 2-oxoglutarate L-cysteinylglycine methyl-2-all- riboflavin synthase: carrier protein] phosphate oxidase: hemF 7,8-dihydrofolate cob(I)yrinic acid a,c-diamide 2-phospho-4-(cytidine terminal glycine in tRNA desulfurase]-(S- reductase: 5'-diphospho)-2-C- Ins(3)P ribotide phosphate sulfanyl) -[disordered- B7445_RS02555 trans-octaprenyl- B7445_RS02875 AIR monoglutamate adenosyltransferase: phosphoglycerate (S)-3- 2 protoporphyrinogen IX methyl-D-erythritol form scaffold 1,4-benzoquinol thiazole synthase: B7445_RS03075 kinase: hydroxydodecanoyl-CoA riboflavin bifunctional 2-C- inositol NADPH repair (prokaryotes) 3 a 3,5,7,9,11,13,15- cobalt- precorrin-6B 5-demethoxyubiquinol- phosphomethylpyrimidine B7445_RS08720 D-glucopyranose ADP-α-D-glucose an N -methyladenine an L-glutamyl- sn-glycerol protein] complex protoporphyrinogen cob(I)yrinic acid a,c-diamide methyl-D-erythritol monophosphatase: B7445_RS02075 5-methoxybenzimidazole NaMN a PII protein hepta-oxo- Ins(2)P a protein precorrin-5B 8 5-hydroxylase synthase ThiC: thiC pyrroloquinoline 6-phosphate in DNA [tRNA Gln ] 3-phosphate 15 bifunctional oxidase HemJ: hemJ adenosyltransferase: cobO B7445_RS09515 3-phospho- UTP precorrin-6B (C ) UbiM: ubiM 2-[(2R,5Z)- 4-phosphate NADPH hexadecanoyl-[PKS-acp]aldo/keto Asp-tRNA(Asn) inositol glycerol-3- ATP- riboflavin kinase/ quinone biosynthesis a 7,8-dihydrofolate D-glycerate methyltransferase: HMP-P 2-carboxy-4- adenosylcobinamide cytidylyltransferase/ inositol reductase: /Glu-tRNA(Gln) monophosphatase: phosphate dependent zinc FAD synthetase: protoporphyrin IX 3-oxododecanoyl-CoA nicotinate-nucleotide-- trehalose-6- DNA-3- a [cysteine desulfurase]- B7445_RS02550 3-demethylubiquinol-8 methylthiazol-5(2H 2-C-methyl-D- monophosphatase: 2,3-bisphosphoglycerate- [protein-PII] B7445_RS14320 amidotransferase: B7445_RS09515 dehydrogenase: metalloprotease B7445_RS09405 a PqqA peptide SAM dimethylbenzimidazole phosphate methyladenine cobalt- [scaffold protein- bifunctional )-ylidene]ethyl bifunctional erythritol 2,4- B7445_RS05640 independent uridylyltransferase: [+ 5 isozymes] gatB gatA gatC inositol glpD FtsH: ftsH precorrin-7 bifunctional 2- ferrochelatase: phosphoribosyltransferase: synthase: glycosylase I: 9-hydroxy-3,5,7,11,13,15- an L-glutaminyl- precorrin-6A (2Fe-2S)] complex FMN hydroxymethylpyrimidine phosphate adenosylcobinamide cyclodiphosphate phosphoglycerate B7445_RS12835 monophosphatase: DHAP polyprenyl-6- B7445_RS11670 myo-inositol cobT B7445_RS14205 B7445_RS15465 hexaoxohexadecanoyl- Gln a peptide cobalt-precorrin- 5 kinase/ γ kinase/adenosylcobinamide- synthase: mutase: [tRNA ] precorrin-7 (C ) hydroxyphenol glutamate C a tetrahydrofolate (R)-NADPHX [PKS-acp] B7445_RS05640 6A reductase: methyltransferase: bifunctional phosphomethylpyrimidine 3 protoheme phosphate B7445_RS10480 B7445_RS06630 bifunctional methylase/3- -tyrosine C decanoyl-CoA α α myo-inositol B7445_RS02555 riboflavin kinase/ kinase: thiD guanylyltransferase: cobU ADP-dependent 5-methoxybenzimidazole , -trehalose an apurinic site a uridylylated a [co-chaperone]- B7445_RS02550 demethylubiquinol 3- 2-(2-carboxy-4- ligase: pqqE 2-C-methyl-D-erythritol- 2-phospho- nicotinate ADP 3-methyladenine FAD synthetase: NAD(P)H-hydrate acyl-CoA/acyl-ACP ribotide phosphate 6-phosphate within DNA PII protein cobalt- [scaffold protein- O-methyltransferase HMP-PP methylthiazol-5- adenosylcobalamin 2,4-cyclodiphosphate D-glycerate precorrin-8x B7445_RS09405 adenosyl-cobinamide phosphate dehydratase/ dehydrogenase: precorrin-6B (2Fe-2S)] complex UbiG: ubiG yl)ethyl phosphate salvage from cobalamin a PqqA peptide with 5,6-dimethylbenzimidazole flavodoxin- phosphopyruvate NAD(P)H-hydrate B7445_RS11725 cobalt-precorrin- SSQ1 precorrin-8X FAD linked Glu-Tyr residues bifunctional dependent hydratase: eno epimerase: a [protein]- a DNA methyl an N-terminal- cytidine 2',3'-cyclic a uracil 1498 6B (C 15 )- chaperone: methylmutase: ubiquinol-8 thiamine cob(I)alamin nicotinate-nucleotide-- acyl-CoA/acyl-ACP 5-hydroxybenzimidazole NaMN O-succinyl-L- L-cysteate long chain adenosylcobinamide (E)-4-hydroxy- B7445_RS04185 L-cysteine phosphotriester L-methionyl-L- monophosphate in 16S rRNA a protein methyltransferase dnaK B7445_RS02570 phosphate dimethylbenzimidazole phosphoenol dehydrogenase: homoserine bifunctional 2',3'- polyphosphate a [chaperone-ATP]- kinase/adenosylcobinamide- 3-methylbut- (S)-NADPHX cysteinyl-[protein] 16S rRNA bifunctional [decarboxylating]: superpathway of heme b synthase: phosphoribosyltransferase: pyruvate B7445_RS01055 cyclic-nucleotide 2'- [co-chaperone]- phosphate 2-enyl- (uracil(1498)-N(3))- aspartate polyphosphate metalloprotease B7445_RS02550 hydrogenobyrinate biosynthesis from glycine B7445_RS08715 2-amino-4-[5-(2-amino- cobT pyruvate nicotinate-nucleotide-- methylated-DNA-- phosphodiesterase/ [scaffold protein- cob(II)alamin guanylyltransferase: cobU diphosphate bifunctional (2E)-dec-2-enoyl-CoA type I methionyl methyltransferase: transaminase/ kinase 2: ppk2 TldD: tldD hydrogenobyrinate thiamine 2-carboxylatoethyl)-2- synthase: ispG kinase: pyk ADP-dependent dimethylbenzimidazole [protein]-cysteine S- O-succinylhomoserine 3'-nucleotidase: B7445_RS10495 aspartate 4- cobalt-precorrin-7 (2Fe-2S)] complex α-ribazole 5'-phosphate aminopeptidase: an N 3 - a,c-diamide synthase: gly phosphate hydroxyphenyl]pentanedioate cob(I)yrinic acid adenosylcobinamide-GDP (E)-4-hydroxy-3- NAD(P)H-hydrate phosphoribosyltransferase: methyltransferase: sulfhydrylase: metZ B7445_RS10485 decarboxylase: long chain pyruvate map methyluracil 1498 a peptide SSQ1 B7445_RS14410 5-aminolevulinate synthase: a,c-diamide methylbut-2-en- dehydratase/ cobT B7445_RS01835 3'-cmp B7445_RS13675 polyphosphate bifunctional cobalt- B7445_RS05715 adenosyltransferase: in 16S rRNA precorrin-7 (C(5))- chaperone hydrogenobyrinate synthase: hemA adenosylcobinamide-GDP 1-yl diphosphate NAD(P)H-hydrate pyridoxal 5'-phosphate biosynthesis I B7445_RS03075 (S)-3- an N-terminal L- 3-sulfopyruvate methyltransferase/ ATPase: dnaK a,c-diamide 5-aminolevulinate 2-amino-4-[3-(2-amino-2- ribazoletransferase: cobS epimerase: 5-hydroxybenzimidazole a [protein]-S- L-homocysteine succinate thiamine cob(I)yrinic acid B7445_RS04185 hydroxydecanoyl-CoA nicotinate [DNA] met cysteinyl-[protein] cobalt-precorrin- carboxylatoethyl)-6-oxocyclohexa- 4-hydroxy- ribotide phosphate methyl-L-cysteine a [chaperone- cobalt chelatase: D-erythrose porphobilinogen phosphate a,c-diamide thiamine diphosphate salvage II 6B (C(15))- an [2Fe-2S] B7445_RS05575 1,4-dien-1-yl]pentanedioate 3-methylbut- ADP]-[disordered- 4-phosphate synthase: hemB NAD de novo biosynthesis adenosyltransferase: adenosylcobalamin 5'-phosphate NADPH methyltransferase: cluster protein [+ 2 isozymes] thiamine- 4-amino-2-methyl-5- 2-enyl form scaffold D-erythrose- I (from aspartate) cobO uridine 2'3'-cyclic B7445_RS02550 phosphate pyrimidinemethanol 4-hydroxy- diphosphate an L-arginyl- a [protein]-L- (2R,3S)-2- protein] complex cob(II)yrinate 4-phosphate porphobilinogen cob(II)alamin- 3-oxodecanoyl-CoA 3-methylbutanoate adenosylcobinamide monophosphate DNA with lesion kinase: thiL 3-methylbut- ala a pimeloyl-[acp] a protein Arg β-isoaspartate methylisocitrate a protein a,c-diamide 6-(2-amino-2-carboxylatoethyl) bifunctional reductase: [tRNA ] bifunctional 2',3'- cobalt-precorrin-8 non- dehydrogenase: asp [corrinoid 2-enyl bifunctional protein-L- excinuclease hydroxymethylbilane thiamine -1,2,3,4-tetrahydroquinoline- hydroxymethylpyrimidine ispH cyclic-nucleotide 2'- chaperonin gap adenosyltranferase] diphosphate adenosylcobinamide isoaspartate O- ABC subunit endopeptidase synthase: hemC diphosphate 2,4-dicarboxylate kinase/ adenosylcobalamin NADH repair (prokaryotes) phosphodiesterase/ molecular 4-phospho- bis(guanylyl molybdopterin) reductase: 8-amino-7- acetate--CoA ligase: acs kinase/ methyltransferase: methylisocitrate UvrB: uvrB La: lon chaperone phosphomethylpyrimidine arginyltransferase: 3'-nucleotidase: D-erythronate cofactor sulfurylation ispH oxononanoate acetate--CoA ligase: acs adenosylcobinamide- βB7445_RS01205 lyase: prpB [+ 3 isozymes] preuroporphyrinogen 2-iminosuccinate kinase: thiD IPP octanoyl-CoA B7445_RS07535 B7445_RS10485 a protein L- - DNA without ATPase: dnaK cob(I)alamin- NADH synthase: bioF phosphate cobyrinate an [Fe-S cluster 6-(2-amino-2-carboxylatoethyl) TCA cycle TCA cycle I (prokaryotic) isoaspartate lesion a peptide uroporphyrinogen- quinolinate [corrinoid HMP-P acyl-CoA/acyl-ACP guanylyltransferase: 3'-UMP α -7-hydroxy-8-oxo-1,2,3,4,7,8- cys -methyl ester biosynthesis III synthase: synthase adenosyltranferase] dehydrogenase: 3-methylbutanoyl-CoA cobU pyruvate succinate cobyrinate A,C- (3R)-3-hydroxy-2-oxo- thioredoxin hexahydroquinoline- (8S)-8-amino-7- diphosphate an N-terminal chaperone]-ATP B7445_RS09865 NadA: nadA cob(I)yrinic acid bifunctional 5-(2-hydroxyethyl) cysteine acetyl-CoA B7445_RS11725 AMP a tRNA Arg adenosyl-cobinamide diamide synthase: 4 phosphooxybutanoate pathway 2,4-dicarboxylate oxononanoate acyl-carrier protein arginyl-[protein] a,c-diamide hydroxymethylpyrimidine -4-methylthiazole desulfurase: acyl-CoA/acyl-ACP phosphate B7445_RS14410 phosphoserine uroporphyrinogen-III an oxidized quinolinate adenosyltransferase: kinase/ B7445_RS02005 DMAPP (R)-NADHX dehydrogenase: cob(II)yrinate transaminase: oxaloacetate D-glyceraldehyde thioredoxin B7445_RS03075 phosphomethylpyrimidine citrate (Si)-synthase: gltA bifunctional B7445_RS01055 a,c-diamide B7445_RS06705 pyruvate uroporphyrinogen carboxylating cysteine NADP 3-phosphate 6-(2-amino-2-carboxyethyl) kinase: thiD 2-methylcitrate ADP-dependent an N 10 - RNase III mRNA a cytidine 1402 5-(methylsulfanyl) dCDP decarboxylase: nicotinate- cob(I)yrinic acid 4-methyl-5-(2- desulfurase: an L-methionyl- isobutanoate ammonium NAD + H O an unfolded biosynthesis 4-phosphooxy- (2E)-oct-2-enoyl-CoA processing 2 cys -2,3-dioxopentyl B7445_RS07245 -7,8-dioxo-1,2,3,4,7,8- a,c-diamide phosphooxyethyl) B7445_RS04505 malate:quinone synthase: prpC NAD(P)H-hydrate [initiator tRNA Met ] formyltetrahydrofolate in 16S rRNA ribonucleotide- protein L-threonine nucleotide HMP-PP 16S rRNA 1-phosphate 1-deoxy-D-xylulose- thioredoxin- hexahydroquinoline adenosyltransferase: thiazole an [L-cysteine oxidoreductase: dehydratase/ diphosphate NAD + diphosphorylase: (cytidine(1402)-2'-O) cysteine 4-hydroxythreonine- 5-phosphate coproporphyrinogen III disulfide 2,4-dicarboxylate cobO desulfurase]-S- B7445_RS00940 NAD(P)H-hydrate acireductone reductase: chaperonin NAD kinase: nadC acetate--CoA ligase: acs nitrite reductase -methyltransferase: dioxygenase: 4-phosphate synthase: reductase: pyrroloquinoline- adenosylcob(III) thiamine sulfanyl-L-cysteine epimerase: methionyl-tRNA ribonuclease synthase: mtnC B7445_RS13325 GroEL: groL B7445_RS16465 oxygen-dependent (S)-malate citrate acetate--CoA ligase: acs small subunit rsmI B7445_RS15335 dehydrogenase B7445_RS16220 trxB NaMN quinone synthase alamin-[corrinoid phosphate cysteine B7445_RS04185 (S)-3- formyltransferase: III: rnc a 2'-O- 1,2-dihydroxy-5- B7445_RS13330 + coproporphyrinogen (S)-NADHX NirD: nirD NADP PdxA: pdxA PqqC: pqqC B7445_RS14780 1402 (methylsulfanyl) adenosyltranferase] synthase: desulfurase: hydroxyoctanoyl-CoA [+ 2 isozymes] methylcytidine 3-sulfino-L-alanine CDP a protein 3-amino-1- 1-deoxy-D- oxidase: hemF nicotinate-nucleotide pent-1-en-3-one cob(I)yrinic acid B7445_RS08715 B7445_RS02005 fumarate hydratase: bifunctional in 16S rRNA hydroxyacetone xylulose 5- a reduced adenylyltransferase: pyrroloquinoline quinone bis(guanylyl Metabolic Regulator Biosynthesis aconitate hydratase an N-formyl- isobutanoyl-CoA diphosphate RNase III protoporphyrinogen IX a,c-diamide thiamine cysteine B7445_RS04530 ADP-dependent AMP an mRNA fragment 1-phosphate phosphate thioredoxin B7445_RS07940 molybdopterin) AcnA: acnA L-methionyl- a tetrahydrofolate processing adenosyltransferase: phosphate desulfurase: class II fumarate NAD(P)H-hydrate nitrite nicotinate adenine cofactor met mRNA protoporphyrinogen B7445_RS03075 synthase: B7445_RS04505 ppGpp metabolism dehydratase/ 3-oxooctanoyl-CoA [initiator tRNA ] pyridoxine 5'- dinucleotide trehalose biosynthesis I fumaratehydratase: fumC cis-aconitate folate transformations III (E. coli) oxidase HemJ: hemJ cob(I)yrinic acid B7445_RS05715 a [bis(guanylyl NAD(P)H-hydrate phosphate NAD + synthetase, molybdopterin) aconitate hydratase a,c-diamide epimerase: a [glycine-cleavage an N-terminal 1402 synthase: protoporphyrin IX pppGpp D-glucopyranose AcnA: acnA an L-arginyl- a cytidine 3'-cmp glutamine NAD(+) synthase: adenosyltransferase: cofactor [bis-MGD cofactor UDP-α-D-glucose B7445_RS04185 a sulfurated [sulfur carrier] SAM complex H protein] 3-sulfino-L- hydrogen selenide O-acetyl-L-serine ala pimeloyl-CoA roseoflavin glyoxylate a tetrahydrofolate B7445_RS04625 thiamine 6-phosphate [tRNA Arg ] in 16S rRNA guanine dependent: B7445_RS09055 cobO chaperone]-S- chaperone]- bifunctional (p)ppGpp N 6 -octanoyl-L-lysine alanyl-[protein] 16S rRNA bifunctional 2',3'- bifunctional glyoxylate ferrochelatase: phosphate hexanoyl-CoA B7445_RS09055 sulfanyl-L-cysteine bis-MGD synthetase/guanosine- NADH (cytosine(1402)-N(4) cyclic-nucleotide 2'- riboflavin kinase/ reductase methionine synthase: metH B7445_RS11670 thiamine- guanosine 3'- trehalose-6- guanine pyridoxine adenosylcobalamin 3',5'-bis(diphosphate) 3'- cysteine )-methyltransferase phosphodiesterase/ FAD synthetase: (NADP(+)): methionine synthase: NAD + phosphate diphosphate 5'- phosphate acyl-CoA/acyl-ACP 8-amino-7- deaminase: bifunctional 5'-phosphate pyrophosphohydrolase: succinate D-threo-isocitrate lipoyl arginyltransferase: synthase RsmH: rsmH 3'-nucleotidase: B7445_RS09405 B7445_RS15325 B7445_RS02155 protoheme kinase: thiL triphosphate 3'- synthase: NADP-dependent dehydrogenase: oxononanoate an N 4 - guaD methylenetetrahydrofolate pyridoxamine B7445_RS03145 synthase: lipA B7445_RS07535 A: cysK B7445_RS10485 roseoflavin diphosphatase: B7445_RS14205 isocitrate B7445_RS11725 synthase: bioF methylcytidine 1402 glycolate xanthine dehydrogenase/ 5'-phosphate 2-methyladeninyl adenosylcobamide thiamine sulfo-bis(guanylyl cytidine 5'-phosphate serine adeninyl adenosylcobamide biosynthesis biosynthesis from adenosylcobinamide-GDP molybdopterin) B7445_RS03145 ADP-forming succinate- dehydrogenase: acyl-CoA/acyl-ACP in 16S rRNA methenyltetrahydrofolate oxidase: pdxH diphosphate α α glycine betaine a [glycine-cleavage an N-terminal L- a 7,8-dihydrofolatehydroxymethyltransferase:a 5-methyltetrahydrofolate from adenosylcobinamide-GDP benzimidazolyl adenosylcobamide cofactor , -trehalose -CoA ligase: sucC sucD B7445_RS12555 dehydrogenase: acetate (8S)-8-amino-7- glycine cleavage system 5'-deoxyadenosine 6 an unsulfurated Arg L-selenocysteine B7445_RS16215 cyclohydrolase FolD: folD biosynthesis from adenosylcobinamide-GDP 6-phosphate biosynthesis I (Gram- B7445_RS01055 met complex H protein] N a tRNA arginiyl-3-sulfino- coenzyme A aminomethyltransferase a (6S)-5-formyltetrahydrofolate PLP 2-methyladenine [sulfur carrier] oxononanoate bifunctional GTP ppGpp trehalose- negative bacteria) -[(R)-lipoyl]-L-lysine L-alanyl-[protein] GcvT: gcvT methylenetetrahydrofolate 5-formyltetrahydrofolate adenine nicotinate-nucleotide-- benzimidazole phosphatase: choline succinyl-CoA 2-oxoglutarate (2E)-hexenoyl-CoA biotin biosynthesis from dimethylbenzimidazole 5-methylbenzimidazolyl adenosylcobamide dehydrogenase/ cyclo-ligase: molybdopterin biosynthesis otsB choline a [pyruvate dehydrogenase E2 an N-terminal dimethyl(3- methylenetetrahydrofolate 8-amino-7-oxononanoate I nicotinate-nucleotide-- phosphoribosyltransferase: nicotinate-nucleotide-- biosynthesis from adenosylcobinamide-GDP nucleoside- an L-arginyl- coenzyme A (S)-2- a holo [PedN acyl- 3'-UMP a dipeptide histidinol methenyltetrahydrofolate B7445_RS05690 dehydrogenase: a sulfurated [sulfur carrier] SAM 6 3-sulfo-L- VibB glu oxopropyl) dimethylbenzimidazole diphosphate GDP α,α-trehalose protein] N -octanoyl-L-lysine Arg reductase: B7445_RS10040 cyclohydrolase FolD: folD (8S)-8-amino-7- dimethylbenzimidazole cobT betA [tRNA ] aminobutanoate carrier protein] bifunctional 2',3'- sulfanium phosphoribosyltransferase: kinase: ndk pyrophosphokinase: bifunctional (p)ppGpp alanyl-[protein] membrane histidinol a 5,10-methylenetetrahydrofolate a 5,10-methenyltetrahydrofolate oxononanoate phosphoribosyltransferase: 5-methylbenzimidazole betaine aldehyde 2-oxoglutarate (S)-3- ACP S- cyclic-nucleotide 2'- betaine-aldehyde adenosylmethionine- cobT GTP B7445_RS03145 synthetase/guanosine- dipeptidase: dehydrogenase: cobT 2-methyladenine dehydrogenase hydroxyhexanoyl-CoA holo-ACP malonyltransferase: phosphodiesterase/ dehydrogenase: bifunctional -8-amino-7- benzimidazole nicotinate-nucleotide-- cys 3',5'-bis(diphosphate) 3'- betaine-aldehyde glutamate-- B7445_RS10555 hisD adenosylcobinamide- ribotide phosphate E1 component: arginyltransferase: synthase: fabD 3'-nucleotidase: betB methylenetetrahydrofolate oxononanoate adenine ribotide adenosylcobinamide- ribotide dimethylbenzimidazole GTP 3',8- pyrophosphohydrolase: dehydrogenase: lipoyl synthase: lipA cysteine ligase: a malonyl[PedN a proteinogenic GDP ATP B7445_RS02500 B7445_RS07535 B7445_RS03150 B7445_RS10485 DMSP his dehydrogenase/ transaminase: adenosylcobinamide- phosphate GDP phosphate phosphoribosyltransferase: cysteine cyclase B7445_RS03145 betB B7445_RS10490 acyl-carrier amino acid thiamine diphosphate methenyltetrahydrofolate B7445_RS10525 GDP cobT desulfurase: MoaA: moaA GDP protein] uridine (7R,8S)- adenosylcobinamide- B7445_RS02005 glycine betaine 3-oxohexanoyl-CoA an N-terminal L- biosynthesis I (E. coli) cyclohydrolase FolD: folD adenosylcobinamide- 5-methylbenzimidazole molybdopterin- GTP 3',8- a [pyruvate dehydrogenase 3',5'-ADP a holo-[VibB aryl- γ-L-glutamyl-(S)- diaminononanoate GDP adenosylcobinamide- 5'-deoxyadenosine Arg GDP cysteine synthase met 6 an unsulfurated [sulfur carrier] a tRNA arginiyl-3-sulfo- carrier protein] 2-[(2R,5Z)- bifunctional adenosylcobinamide- ribazoletransferase: GDP ribotide phosphate cyclase E2 protein] N -lipoyl-L-lysine 2-aminobutanoate dethiobiotin ribazoletransferase: desulfurase: adenylyltransferase L-alanyl-[protein] 2-carboxy-4- methylenetetrahydrofolate GDP cobS MoaA: moaA methylthiazol-5(2H synthase: bioD ribazoletransferase: cobS B7445_RS04505 MoeB: moeB (8S)-3',8-cyclo-7,8- dehydrogenase/ adenosylcobinamide- an [L-cysteine a carboxy-adenylated )-ylidene]ethyl methenyltetrahydrofolate cobS Coα-[α-(2- dihydroguanosine butanoyl-CoA UDP-N-acetyl-α-D-muramoyl-L- all-trans- 6-O-cis-keto- HMP-PP dethiobiotin Coα-[α- GDP desulfurase]-S- [small subunit of coenzyme A an apo [peptidyl- NADP + FMNH a holo [PedD acyl- 3-aminopropanal D-glucopyranose (2E,6E)-farnesyl phosphate cyclohydrolase FolD: folD methyladenin-9-yl)]-Co 5'-triphosphate alanyl-γ-D-glutamyl-meso-2,6- decaprenyl 2 mycolyl-trehalose Coα-[α-(adenin-9-yl)]- (benzimidazolyl)]-Co ribazoletransferase: sulfanyl-L-cysteine molybdopterin synthase] carrier protein] 4-hydroxybenzoate carrier protein] diphosphate biotin β-adenosylcobamide cyclic pyranopterin acyl-CoA/acyl-ACP diaminopimeloyl-D-alanyl-D-alanine diphosphate betaine-aldehyde glucose 1- 6-phosphate presqualene 10 β β-adenosylcobamide cobS thiamine an N -formyltetrahydrofolate Co -adenosylcobamide 5'-phosphate monophosphate dehydrogenase: ACP S- dehydrogenase: trehalose- synthase 5'-phosphate dehydrogenase: diphosphate phosphate dipyrromethane 5'-phosphate tetrahydrofolate salvage from α α synthase B7445_RS11725 holo-ACP flavin reductase: malonyltransferase: B7445_RS01660 phosphatase: BioB: bioB Co -[ -(5- penicillin-binding 4-hydroxybenzoate betB synthase synthase: phosphopantothenate biosynthesis I cofactor biosynthesis 5,10-methenyltetrahydrofolate MoaC: moaC acyl-CoA/acyl-ACP synthase: B7445_RS01320 fabD [+ 2 isozymes] otsB methylbenzimidazolyl)]- a thiocarboxylated protein 2: mrdA octaprenyltransferase: a malonyl- trehalose-cis-keto- HpnD: hpnD B7445_RS08715 9-mercaptodethiobiotin β dehydrogenase: B7445_RS03150 [+ 3 isozymes] β-alanine D-glucono- an apo-[hydroxymethylbilane a 5,10- Coα-[α-(2- Co -adenosylcobamide [small subunit of cyclic pyranopterin ubiA [PedD acyl- mono-mycolate squalene α α Coα-[α- B7445_RS01055 1,5-lactone thiamine 3-methyl-2-oxobutanoate biotin synthase]-L-cysteine Co -[ -(adenin-7-yl)]- methenyltetrahydrofolate methyladenin-7-yl)]-Co 5'-phosphate molybdopterin synthase] phosphate carrier protein] heme a biosynthesis β bifunctional (benzimidazolyl)]-Co UDP-N-acetylmuramoyl-L- phosphate Co -adenosylcobamide β-adenosylcobamide a holo [peptidyl- + synthase methylenetetrahydrofolate β-adenosylcobamide crotonyl-CoA γ 3',5'-ADP 3-decaprenyl-4- FMN NADPH H synthase: 3-methyl-2-oxobutanoate D-ala alanyl- -D-glutamyl-meso-2,6- carrier protein] BioB: bioB a [hydroxymethylbilane dehydrogenase/ S-adenosyl-L- hydroxybenzoate B7445_RS05715 hydroxymethyltransferase: protoheme α α diaminopimeloyl-D-alanine synthase] ES intermediate methenyltetrahydrofolate methionine salvage II Co -[ -(5- panB protoheme IX biotin 2 cyclohydrolase FolD: folD methylbenzimidazolyl)]- di-trans,poly-cis farnesyltransferase: hydroxymethylbilane β molybdopterin thiamine 2-dehydropantoate SAH Co -adenosylcobamide -undecaprenyl an apo-[LYS2 L- all-trans- a [protein]-α- B7445_RS03970 synthase: hemC bifunctional (S)-3- dethiobiotin a sulfurated coenzyme A FMN NADH H + a holo [BryU acyl- D-glucopyranose pyridoxamine phosphate phosphate biosynthesis SAM 2-aminoadipyl- hexaprenyl L-glutamate trp ferroheme o methylenetetrahydrofolate adenosylhomocysteinase: hydroxybutanoyl-CoA [sulfur carrier] 4-hydroxybenzoate carrier protein] 5'-phosphate a [hydroxymethylbilane (2E,6E)-farnesyl carrier-protein] diphosphate protein-glutamate O- glucose 1- thiamine- dehydrogenase/ B7445_RS07370 IPP ACP S- tryptophan 7- pyridoxamine synthase] ES intermediate diphosphate methyltransferase: dehydrogenase: phosphate heme A synthase: 3 methenyltetrahydrofolate flavin reductase: 5'-phosphate L-homocysteine β biotin holo-ACP 4-hydroxybenzoate malonyltransferase: B7445_RS08180 halogenase: kinase: thiL β B7445_RS15510 hydroxymethylbilane cyclohydrolase FolD: folD cytidylyl molybdenum fatty acid -oxidation I (generic) B7445_RS01320 B7445_RS09960 oxidase: pdxH -alanine 10 synthase synthase: fabD a [protein]-L- [+ 2 isozymes] B7445_RS05475 (R)-pantoate synthase: hemC an N - cofactor sulfurylation di-trans,poly-cis- octaprenyltransferase: a malonyl- thiamine methionine synthase: metH acetoacetyl-CoA [+ 3 isozymes] 5 D-glucono- 7-chloro-L- ferroheme i formyltetrahydrofolate decaprenylcistransferase: BioB: bioB B7445_RS03150 ubiA [BryU acyl- glutamate-O PLP diphosphate a [hydroxymethylbilane methionine synthase: cytidylyl molybdenum a (3Z)-alk-3-enoyl-CoA 1,5-lactone tryptophan phosphoribosylglycinamide uppS carrier protein] -methyl-ester pantoate--beta-alanine synthase] ES intermediate B7445_RS02155 cofactor (trioxo) a holo-[LYS2 L- heme A synthase: 4 ligase: B7445_RS04945 formyltransferase: biotin 5'-deoxyadenosine met an unsulfurated 3',5'-ADP 2-aminoadipyl- 3-hexaprenyl-4- FMNH NAD + B7445_RS15510 hydroxymethylbilane B7445_RS11160 di-trans,octa-cis [sulfur carrier] 2 met molybdenum an [MCD cofactor carrier-protein] hydroxybenzoate folate polyglutamylation synthase: hemC cofactor biosynthesis -undecaprenyl acetyl-CoA (R)-pantothenate hydroxyferroheme i a tetrahydrofolate chaperone]-MCD diphosphate a holo-[hydroxymethylbilane methionine NAD a (2E)-2-enoyl-CoA cysteine undecaprenyl- all-trans- a supercoiled UDP synthase] adenosyltransferase: molybdopterin phosphorylation and + type III pantothenate a tetrahydrofolate 5,6-dimethylbenzimidazole molybdate desulfurase: diphosphate Reactive Blue 5 coenzyme A AsbD acyl- nonaprenyl A NADPH H a holo [BryP acyl- (S)-5-hydroxyisourate a D-hexose B7445_RS14505 transhydrogenation 4-hydroxybenzoate duplex DNA ribonucleotide- kinase: B7445_RS04295 biosynthesis I (aerobic) B7445_RS02005 phosphatase: acyl-CoA/acyl-ACP carrier protein diphosphate carrier protein] replicative glutathione- glucokinase: diphosphate glutaredoxin B7445_RS06455 NAD + a 2,3,4-saturated dehydrogenase: ACP S- hydroxyisourate DNA helicase: (R)-4'-phosphopantothenate ferroheme a bifunctional serine SAM cysteine Dyp-type NADPH B7445_RS01215 reductase: redox reactions glutathione- riboflavin di-trans,octa-cis NAD kinase: fatty acid B7445_RS01055 a 2,3,4-saturated (3R holo-ACP malonyltransferase: hydrolase: uraH B7445_RS14370 folylpolyglutamate hydroxymethyltransferase: molybdopterin desulfurase: peroxidase: 4-hydroxybenzoate dehydrogenase B7445_RS13325 peroxide bifunctional riboflavin -undecaprenyl B7445_RS16465 acyl--CoA ligase: acyl-CoA/acyl-ACP )-3-hydroxyacyl-CoA synthase: fabD (S)-2-oxo-4- [+ 3 isozymes] synthase/ B7445_RS16215 an N 10 - glutathione adenine B7445_RS04505 B7445_RS14825 octaprenyltransferase: NamA: namA a malonyl- D-hexose 6- B7445_RS13330 redox reactions kinase/FAD synthetase: molybdate phosphate + B7445_RS11585 dehydrogenase: a single dihydrofolate dinucleotide a [cytidylyl molybdenum NADP a 2,3,4-saturated a 2,3,4-saturated (3S B7445_RS03150 ubiA [BryP acyl- hydroxy-4-carboxy- phosphate formyltetrahydrofolate B7445_RS09405 B7445_RS11725 stranded DNA dUDP synthase: a 5,10- GSSG cofactor chaperone]- fatty acyl CoA )-3-hydroxyacyl-CoA carrier protein] 5-ureidoimidazoline bifunctional FMN NAD(P) 2,2'-disulfonyl 3-[(4-amino-6-chloro- B7445_RS09065 methylenetetrahydrofolate molybdopterin cytidylyl molybdenum a holo-[AsbD acyl- + acyl carrier folylpolyglutamate a reduced transhydrogenase: 1,3,5-triazin-2-yl) phthalate 3',5'-ADP 3-nonaprenyl-4- A(H2) NADP molybdotransferase cofactor (sulfo-dioxo) azobenzene carrier protein] protein activation bifunctional synthase/ glutaredoxin flavin reductase: B7445_RS00610 amino]benzenesulfonate hydroxybenzoate glutathione- MoeA: coenzyme A a tetrahydrofolate folylpolyglutamate dihydrofolate glutaredoxin B7445_RS15305 B7445_RS00615 an apo acyl- disulfide B7445_RS09045 synthase/ synthase: 2: grxB [+ 3 isozymes] carrier protein dihydrofolate reductase: an [HPr]- phosphoenol lysine within all-trans- a guanine 527 holo-ACP B7445_RS09065 glutaredoxin MoO - NADPH dihydrolipoamide N-ethylmaleimide a uridine in tRNA nitric oxide CAIR FMNH 2 a 2,3,4-saturated a 2,3,4-saturated an octanoyl-[acp] heptaprenyl synthase: gorA 2 L-histidine pyruvate gcv protein H 4-hydroxybenzoate in 16S rRNA synthase: an N 10 - 3: grxC molybdopterin B7445_RS09065 fatty acyl CoA 3-oxoacyl-CoA diphosphate pyruvate 16S rRNA alkene reductase: tRNA NO-inducible 5-(carboxyamino) B7445_RS03150 formyltetrahydrofolate a protein with cofactor phospholipases a holo acyl- 5,6-dimethylbenzimidazole dehydrogenase (guanine(527)-N(7) B7445_RS08275 dihydrouridine flavohemoprotein: imidazole carrier protein a 5,10- reduced L- synthase: bluB phosphoenolpyruvate- lipoyl(octanoyl) )-methyltransferase synthase ribonucleotide glutathione a 1,2-diacyl- 4-hydroxybenzoate complex alkene reductase: hmpA methylenetetrahydrofolate cysteine residues -protein transferase RsmG: rsmG DusB: dusB mutase: purE a phosphatidylcholine sn-glycerol octaprenyltransferase: dihydrolipoamide an N 7 - B7445_RS16190 5,6-dimethylbenzimidazole phosphotransferase: ptsP LipB: lipB a 5,6-dihydrouridine nitrate 3-phosphate ubiA acetyltransferase: 527 N-ethylsuccinimide AIR methylguanine in tRNA B7445_RS12920 in 16S rRNA a 1-acyl-sn an [HPr protein]- a [glycine-cleavage acetyl-CoA π pyruvate S-acetyldihydrolipoamide -glycero-3- N -phospho- acyl-carrier protein complex H protein] 3-heptaprenyl-4- a phosphatidylcholine 6 phosphocholine L-histidine N -octanoyl-L-lysine hydroxybenzoate

a 2-acyl-sn an L-1- an (S-diacyl-sn- a 2,3,4-saturated (R)-S- a guanine 966 a negatively an organic 7,8-dihydro- -glycero-3- C1 Compound Utilization and Assimilation coenzyme A an apo-[aryl- squalene a phosphatidylcholine phosphatidylethanolamine glyceryl)-L-cysteinyl- 1,2-diacyl-sn- lactoylglutathione in 16S rRNA supercoiled DNA hydroperoxide 8-oxoguanine phosphocholine carrier protein] [apolipoprotein] glycerol 3-phosphate CTP 16S rRNA DNA alkyl 8-oxoguanine squalene- formaldehyde oxidation (guanine(966)-N(2) topoisomerase hydroperoxide deaminase: -hopene VII (THF pathway) formaldehyde oxidation phospholipase C, II (glutathione-dependent) apolipoprotein N- holo-ACP phosphatidate hydroxyacylglutathione )-methyltransferase IV subunit B: parE reductase: B7445_RS09050 cyclase: synthase: hydrolase: gloB RsmD: rsmD B7445_RS07560 shc phosphocholine- acyltransferase: lnt cytidylyltransferase: an N 2 - [+ 2 isozymes] formaldehyde B7445_RS03150 urate specific: formaldehyde B7445_RS03185 methylguanine 966 a relaxed DNA an alcohol hop-22(29)-ene B7445_RS09680 an N-acyl-(S-diacyl- in 16S rRNA a 2-acyl-1-lyso- (R)-lactate glutathione phospholipase C, a 5,10- sn-glyceryl)-L- 3',5'-ADP a holo-[aryl- a CDP-2,3,4-saturated- S-(hydroxymethyl) phosphatidylethanolamine phosphocholine- methylenetetrahydrofolate cysteinyl-[lipoprotein] carrier protein] diacylglycerol glutathione specific: bifunctional B7445_RS00935 S-(hydroxymethyl) a 1,2-diacyl- methylenetetrahydrofolate 1 a phosphatidylcholine glutathione an N - a 2'- adenine 1518 / a guanine 46 sn-glycerol dehydrogenase/ 2-oxoglutarate coenzyme A [EntB aryl- dihydroxyacetone (S)-malate dehydrogenase/ ethyladenine deoxyribonucleoside adenine 1519 in 16S rRNA in tRNA thr ser methenyltetrahydrofolate carrier protein] [DNA] dihydroxyacetone class III alcohol in DNA 5'-triphosphate 16S rRNA tRNA malate:quinone a 1-phosphatidyl- cyclohydrolase FolD: folD kinase threonine L-serine a 1,2-diacyl- dehydrogenase: (adenine(1518)-N(6)/ (guanosine(46)-N7) oxidoreductase: 1D-myo-inositol subunit DhaK: ammonia-lyase: ammonia-lyase: sn-glycerol bifunctional B7445_RS10120 DNA oxidative holo-ACP RNA-directed adenine(1519)-N(6))- -methyltransferase B7445_RS00940 4,5-bisphosphate B7445_RS01165 B7445_RS07950 B7445_RS10080 methylenetetrahydrofolate demethylase synthase: DNA polymerase: dimethyltransferase 7 TrmB: trmB an N - oxaloacetate dehydrogenase/ S-formylglutathione AlkB: alkB B7445_RS03150 RsmA: rsmA 46 2-oxobutanoate pyruvate B7445_RS07030 N 6 -dimethyladenine 1518 methylguanine DHAP methenyltetrahydrofolate 6 1519 in tRNA S-formylglutathione /N -dimethyladenine cyclohydrolase FolD: folD a holo-[EntB aryl- hydrolase: fghA acetaldehyde an adenine in DNA succinate 3',5'-ADP in 16S rRNA a 5,10- carrier protein] [DNA] methenyltetrahydrofolate formate bifunctional 1 α methylenetetrahydrofolate an N - α-D-glucopyranose guanine 37 L-gulono- 6-O- -mycolyl- 2-oxoglutarate coenzyme A [EntF L-seryl- an isoprenoid coniferaldehyde nicotinamide methyladenine 4-hydroxybenzoate Phe trehalose 6- Carbohydrate Degradation dehydrogenase/ carrier protein] diphosphate CTP 1-phosphate in tRNA 1,4-lactone methenyltetrahydrofolate in DNA tRNA coniferyl aldehyde gluconolactonase: phosphate (guanosine(37)-N1) B7445_RS14895 nicotinamidase: trehalose- cyclohydrolase FolD: folD glucose-1-phosphate dehydrogenase: phosphatase: trehalose degradation II (cytosolic) DNA oxidative holo-ACP 4-hydroxybenzoate -methyltransferase gluconolactonase: B7445_RS13360 bifunctional cytidylyltransferase: B7445_RS02050 otsB demethylase synthase: octaprenyltransferase: 1 TrmD: trmD B7445_RS10915 methylenetetrahydrofolate rfbF an N - ferulate nicotinate α, α'-trehalose α α AlkB: alkB B7445_RS03150 ubiA 37 , -trehalose dehydrogenase/ methylguanine L-gulonate 6-α-mycolate in tRNA Phe methenyltetrahydrofolate a holo-[EntF CDP-α-D-glucose alpha,alpha- trehalose degradation cyclohydrolase FolD: folD an adenine in DNA formaldehyde succinate 3',5'-ADP L-seryl-carrier a 4-hydroxy-3- trehalase TreF: treF VI (periplasmic) polyprenylbenzoate an N 10 - protein] α,α-trehalose formyltetrahydrofolate α-D-glucopyranose β-D-glucopyranose 3 formyltetrahydrofolate an N - an N-terminal L- 37 an N-terminal L- an L-arginyl- a single- a guanine (R)-10- deformylase: 2-oxoglutarate methylcytosine alanyl-[S18 protein oxaloacetate D-glycerate gly alpha,alpha- aspartyl-[protein] [tRNA Arg ] stranded RNA in tRNA Hydroxystearate B7445_RS11590 in DNA of 30S ribosome]ribosomal protein tRNA trehalase TreF: treF 2-methylcitrate oleate hydratase: glycerate kinase: glycine formyltetrahydrofolate S18-alanine N- (guanosine(37)-N1) DNA oxidative polyribonucleotide -methyltransferase synthase: prpC B7445_RS09415 B7445_RS06050 oxidase D-glucopyranose α β deformylase: arginyltransferase: acetyltransferase: -D-glucopyranose -D-glucopyranose demethylase nucleotidyltransferase: pnp TrmD: trmD ThiO: thiO B7445_RS14250 B7445_RS07535 an N-terminal N-acetyl-rimI an N 1 - 1,2-dihydroxypropane- 2-phospho- AlkB: alkB oleate glucokinase: L-alanyl-[S18 protein methylguanine 37 1,2,3-tricarboxylate D-glycerate glyoxylate B7445_RS01215 formate an N-terminal a single- of 30S ribosome] in tRNA Arg a nucleoside a cytosine in DNA formaldehyde succinate a tRNA L-arginiyl-L- stranded RNA D-glucopyranose 6-phosphate aspartyl-[protein] diphosphate

Detoxification a [histone]-N 6 - (S)-2-oxo-4- + an N-terminal L- an L-arginyl- + an insertion sequence adenosyl-cob(III) NAD phylloquinone NAD(P)H H hydroxy-4-carboxy- (R)-lactate formamide D-ala acetyl-L-lysine glutamyl-[protein] [tRNA Arg ] element IS30 yrinate a,c-diamide arsenate arsenate 5-ureidoimidazoline transposase: cobyric acid reactive oxygen species degradation 8-oxo-(d)GTP detoxification I 2-oxo-4-hydroxy- D-lactate formamidase: glycine detoxification detoxification B7445_RS07360 synthase: NAD-dependent NAD(P)H:quinone 4-carboxy-5- dehydrogenase: dld B7445_RS07180 oxidase II (glutaredoxin) III (thioredoxin) arginyltransferase: ureidoimidazoline [+ 23 isozymes] B7445_RS14400 superoxide deacylase: oxidoreductase: ThiO: thiO arsenate arsenate B7445_RS07535 decarboxylase: uraD an insertion dGTP GTP B7445_RS06905 wrbA sequence IS30 with adenosylcobyrate pyruvate formate arsenate arsenate (S)-(+)-allantoin pyruvate superoxide dismutase: integrated transposon reductase reductase B7445_RS03110 2''-O-acetyl- an N-terminal (glutaredoxin) (glutaredoxin) a [histone]-L-lysine nicotinamide a tRNA Arg L-arginiyl-L- NAD(P) + phylloquinol 8-oxo-dGTP 8-oxo-GTP ADP-ribose : arsC : arsC hydrogen peroxide glutamyl-[protein] [+ 2 isozymes] [+ 2 isozymes] 8-oxo-dGTP arsenite arsenite diphosphatase 3-methyl-2- 5,10-methylene- a methylated catalase: MutT: mutT 2-oxoglutarate NAD(P)H a plastoquinone H + hydantoin an adenine in DNA reduced riboflavin wound RNA (R)-lactate citrate B7445_RS11705 oxobutanoate tetrahydromethanopterin nucleobase 8-oxo-GMP within DNA type I restriction- 8-oxo-dGMP flavin reductase: D-2-hydroxyacid aconitate H O hydroxyl radical dihydropyrimidinase: modification RNA helicase: 2 3-methyl-2-oxobutanoate B7445_RS15305 dehydrogenase: hydratase O DNA oxidative NAD(P)H:quinone hydA system subunit M: B7445_RS01875 arsenite arsenite 2 hydroxymethyltransferase: [+ 3 isozymes] B7445_RS11310 AcnA: acnA demethylase oxidoreductase: B7445_RS13645 panB wrbA 6 Aromatic Compound Degradation AlkB: alkB N-carbamoylglycine an N -methyladenine riboflavin an unwound RNA pyruvate D-threo-isocitrate in DNA

quinate degradation I 2-dehydropantoate THMPT formaldehyde a nucleobase succinate a plastoquinol NAD(P) + shikimate degradation I within DNA L-quinate shikimate 6 glucose/quinate/ + a [protein]-N - D-threo-7,8- (2R,3S)-3- glucose/quinate/ NAD a lipid II L,L- 3-oxopropanoate ferroheme o Fe 2+ 7,8-dihydropterin shikimate family acetyl-L-lysine dihydroneopterin diaminopimelate isopropylmalate membrane-bound shikimate family malonic 3-isopropylmalate guanine LL-diaminopimelate heme A synthase: PQQ-dependent membrane-bound semialdehyde dehydrogenase: bacterioferritin: bfr deaminase: NAD-dependent penicillin-binding aminotransferase: B7445_RS15510 dehydrogenase: PQQ-dependent dihydroneopterin reductase: leuB guaD deacylase: protein 2: mrdA B7445_RS07065 B7445_RS08585 dehydrogenase: aldolase: folB B7445_RS07315 4-methyl-2- 7,8- B7445_RS08585 B7445_RS06905 (S)-2,3,4,5- ferroheme a Fe 3+ 3-dehydroquinate tetrahydrodipicolinate 3-hydroxypropanoate oxopentanoate dihydrolumazine 3-dehydroshikimate a N-acetylglucosamine--N- type II 3- 2''-O-acetyl- 6-(hydroxymethyl) glycolaldehyde nicotinamide a [protein]-L-lysine D-ala acetylmuramyl-(tetrapeptide) dehydroquinate ADP-ribose pyrophosphoryl-undecaprenol -7,8-dihydropterin dehydratase: aroQ Nucleoside and Nucleotide Degradation 3-dehydroshikimate protocatechuate 5-amino-4- S-(2-hydroxyacyl) a 5' triphospho- (2R,3S)-3- phosphoenol H + hydrogencarbonate a [protein] Ser/Thr imidazolecarboxyamide PRPP MeOH oxaloacetate 5'-deoxyadenosine glutathione [mRNA] isopropylmalate pyruvate RNA 3-isopropylmalate degradation I thymine degradation HPr kinase: catalase: 2-methylcitrate pyruvate pyrophosphohydrolase: dehydratase: adenine carbonic B7445_RS01565 B7445_RS11705 synthase: prpC kinase: pyk hydroxyacylglutathione B7445_RS06610 leuC leuD 5'-deoxyadenosine thymine protocatechuate phosphoribosyltransferase: anhydrase: dihydrothymine hydrolase: gloB B7445_RS15490 B7445_RS05730 a 5'-phospho- a [protein] (L-serine/L- (2S)-2- formaldehyde (2S,3S)-2- pyruvate S-methyl-5'- dehydrogenase: [mRNA] threonine) phosphate isopropylmalate methylcitrate preA thioadenosine a 2-hydroxy phosphorylase: 5,6-dihydrothymine AICAR CO H O glutathione 2 2 carboxylate B7445_RS03765 dihydropyrimidinase: pyrimidine deoxyribonucleotides 5-deoxy-α-D- hydA dephosphorylation nucleoside triphosphate (R)-4'- ribose 1-phosphate 3-(carbamoylamino)- UDP-N-acetyl-α-D-muramoyl- DNA combined with dCTP pyrophosphohydrolase: D-alanyl-D-alanine phosphopantothenoyl- exogenous DNA to form uroporphyrinogen-III uroporphyrinogen-I 5,6-dihydrouracil ethanol S-methyl-5- 2-methylpropanoate L-alanyl-γ-D-glutamyl-L-lysine mazG L-cysteine a recombinational junctionHolliday junction uroporphyrinogen-III uroporphyrinogen NAD-dependent dCTP deaminase: thioribose-1- dCTP dCMP bifunctional catalase: resolvase RuvX: ruvX C-methyltransferase: decarboxylase: dihydropyrimidine B7445_RS06240 phosphate UDP-N-acetylmuramoyl- phosphopantothenoylcysteine B7445_RS11705 isomerase: mtnA decarboxylase/ crossover junction cobA B7445_RS07245 dehydrogenase dUTP diphosphatase: dut tripeptide--D-alanyl-D- dUTP (R)-3-amino-2- alanine ligase: murF phosphopantothenate endodeoxyribonuclease subunit PreA: preA 5-deoxy-D-ribulose nucleoside triphosphate precorrin-2 coproporphyrinogen I acetaldehyde methylpropanoate synthase: B7445_RS00305 resolution of recombinationalRuvC: ruvC uracil 1-phosphate pyrophosphohydrolase: α 4'-phosphopantetheine junction formation mazG UDP-N-acetyl- -D-muramoyl-L-alanyl- dUTP dUMP γ-D-glutamyl-L-lysyl-D-alanyl-D-alanine of two intact strands

S-methyl-5'- 2,5-diamino-6-(5- 6-[1-hydroxyethyl]-7- a pseudouridine 1915 2'-deoxycytidine a uridine 55 5,6- β-D-fructose 1,6- CTP acetaldehyde DHAP 5-hydroxy-CTP 5-hydroxy-CMP thioadenosine phospho-D-ribitylamino) methyl-7,8-dihydropterin in 23S rRNA in tRNA dihydrothymine bisphosphate nucleoside deaminase: NAD-dependent degradation II pyrimidin-4(3H)-one bifunctional 2-amino-4-hydroxy-6- 23S rRNA tRNA class II fructose- dCTP deaminase: S-methyl-5'- B7445_RS04575 dihydropyrimidine diaminohydroxyphosphoribosylaminopyrimidine hydroxymethyldihydropteridine (pseudouridine(1915)- pseudouridine(55) bisphosphatase: B7445_RS06240 thioadenosine cytidine deaminase: dehydrogenase S-methyl-5'- deaminase/5-amino-6-(5-phosphoribosylamino) diphosphokinase: folK N(3))-methyltransferase synthase TruB: truB glpX [1-(2-amino-7-methyl-4-oxo- RlmH: B7445_RS06650 B7445_RS11400 subunit PreA: preA UTP thioadenosine uracil reductase RibD: ribD an N 3 - a pseudouridine 55 5-amino-6-(5-phospho- 7,8-dihydro-3H-pteridin- 2'-deoxyuridine thymine F6P phosphorylase: methylpseudouridine 1915 in tRNA B7445_RS03765 D-ribitylamino)uracil 6-yl)]ethyl diphosphate in 23S rRNA 5-MTR-1-P

a purine D-glucose 2-dehydro- a C4- a C4- an inorganic an inorganic 3-deoxy-D- an aliphatic D-fructose an nucleoside D-galactose a lipopolysaccharide a polysaccharide a polysaccharide dicarboxylate dicarboxylate anion anion gluconate sulfonate 1-phosphate oligopeptide

RS07105 LptC GluP RS12390 RS06560 RS10895 DctA RS06800 RS10035 RS00620 RS12980 RS01555 RS00265

2-dehydro- a C4- a C4- an inorganic an inorganic an aliphatic D-fructose an a purine a lipopolysaccharide D-galactose a polysaccharide a polysaccharide dicarboxylate dicarboxylate anion anion 3-deoxy-D- sulfonate oligopeptide nucleoside gluconate D-glucose This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.