Authors: Carol A Fulcher An online version of this diagram is available at BioCyc.org. Biosynthetic pathways are positioned in the left of the cytoplasm, degradative pathways on the right, and reactions not assigned to any pathway are in the far right of the cytoplasm. Transporters and membrane proteins are shown on the membrane. Anamika Kothari Periplasmic (where appropriate) and extracellular reactions and proteins may also be shown. Pathways are colored according to their cellular function. ClostsymbCyc: [Clostridium] symbiosum WAL-14163 Cellular Overview Connections between pathways are omitted for legibility. Peter D Karp phosphate spermidine spermidine spermidine an amino an amino an amino an amino an amino an amino an amino Ni 2+ Ni 2+ ethanolamine phosphate putrescine putrescine putrescine acid acid acid acid acid acid acid a dipeptide a dipeptide

predicted predicted predicted ABC ABC ABC RS01570 RS07160 RS14070 RS21075 RS21150 RS17680 RS18470 RS01565 RS23185 RS20680 RS00845 RS04120 RS17120 RS14725 SecA RS24405 RS13120 RS06800 RS23730 RS17310 RS10020 RS10425 RS11815 RS21960 RS20055 RS07155 RS13880 RS14555 RS06760 RS07585 RS14230 RS09955 RS14405 RS17740 RS20565 RS07930 RS17955 RS09185 RS02520 RS02600 RS05610 RS11750 RS10535 RS02845 RS03005 RS19890 RS19975 RS16570 RS18780 RS12595 transporter RS13600 transporter RS22725 RS13470 RS18615 RS13230 RS01060 RS09515 RS18205 RS20895 RS16480 RS15650 RS05740 RS01485 RS13700 RS12385 RS20770 RS09275 RS19425 RS00225 RS21655 RS14145 RS01410 RS19380 RS18300 RS23425 RS18765 RS10955 RS01040 RS18190 RS20710 RS14825 RS17135 RS16620 RS21940 RS11885 RS00610 RS19325 RS13930 RS20190 RS10740 RS10315 RS05210 RS06635 RS11085 RS15610 RS23090 RS19980 RS11415 RS04745 RS01535 RS04415 RS20235 RS03410 RS08370 RS21230 RS14475 RS17165 RS08545 RS03745 RS06775 RS23165 RS02055 RS14160 RS00160 RS07600 RS05110 RS10050 RS00495 RS15265 RS20830 RS15930 RS18220 RS11845 RS02860 RS19735 RS21820 RS16255 RS16335 transporter of spermidine/ of spermidine/ of phosphate RS22045 putrescine putrescine RS12155 spermidine phosphate Ni 2+ Ni 2+ ethanolamine an amino an amino an amino an amino an amino an amino an amino putrescine acid acid acid acid acid acid acid a dipeptide a dipeptide spermidine spermidine phosphate RS11045 putrescine putrescine RS06820

Amino Acid Degradation RS02765 RS12615 Degradation/Utilization/ Aminoacyl-tRNA Charging glutaminyl-tRNA gln Assimilation - Other UDP-N-acetyl- undecaprenyl- a peptidoglycan dimer (1S,2R)-1- 1-stearoyl- 1-stearoyl- UDP-N-acetylmuramoyl- DNA combined 2-(2-carboxy-4- N-acetyl-α- biosynthesis via transamidation L-histidine degradation III 2503 a lipid II ATP biotin RS20340 α-D-glucosamine adenine in 23S rRNA γ 3',5'-ADP a purine 2'- acetyl-CoA propanoyl-CoA Asx methylthiazol-5- heterolactic fermentation Fermentation L-isoleucine degradation I L-serine degradation L-glutamine degradation I acetoacetate degradation diphospho-N- with pentapeptide ser C-(indol-3- sn-glycerol an oleoyl-[acp] sn-glycerol a palmitoyl-[acp] arg L-alanyl- -D- sulfite 2'-deoxyguanosine a tRNA asp with exogenous HMP-PP D-muramoyl- XMP GTP deoxyribonucleoside yl)ethyl phosphate (to acetyl CoA) acetylmuramoyl- stems (meso- yl)glycerol 3-phosphate 3-phosphate glutamyl-meso-2,6- DNA to form a L-alanine(1-) his RS00880 his Glu L-alanyl-γ-D- 3-phosphate recombinational multifunctional 2',3'- nucleotide RS23380 Gln β diaminopimelate diaminopimeloyl- glutamyl-tRNA -D-fructofuranose his gln 23S rRNA acetyl-CoA D-Ala-D-Ala Holliday junction bifunctional biotin-- cyclic-nucleotide 2'- pyrophosphohydrolase: ile ser glutamyl-L-lysyl- containing) 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- arginase: D-alanine phosphoadenosine aspartate-- junction thiamine phosphate N-acetylmuramoyl- synthetase: L-valine degradation I glutaminase A: acetoacetate methyltransferase: tryptophan synthase acetyltransferase: carboxypeptidase: resolvase RecU: [acetyl-CoA-carboxylase] phosphodiesterase/ HMPREF9474_RS22635 sulfite RS19090 sulfite histidine ammonia-lyase: L-serine dehydratase, acetoacetyl-CoA D-alanyl-D-alanine phosphate acyltransferase: phosphate acyltransferase: HMPREF9474_RS00470 phosphosulfate purine-nucleoside purine-nucleoside tRNA(Asn) ligase: HMPREF9474_RS05600 HMPREF9474_RS09870 synthase: L-alanine amidase: RS13920 HMPREF9474_RS04105 fructokinase: HMPREF9474_RS00485 UDP-N-acetylglucosamine- HMPREF9474_RS15805 subunit beta: HMPREF9474_RS03210 synthetase/biotin 5'-nucleotidase/ nucleotide an L-glutamyl- HMPREF9474_RS01635 branched chain amino iron-sulfur-dependent transferase: N-acetylmuramoyl- HMPREF9474_RS19650 HMPREF9474_RS19650 SpeB arginase/agmatinase/ sulfurtransferase: phosphorylase: phosphorylase: HMPREF9474_RS09635 HMPREF9474_RS15405 HMPREF9474_RS06175 Gln -N-acetylmuramyl- LD-carboxypeptidase: [+ 2 isozymes] crossover junction operon repressor: 3'-nucleotidase: [tRNA ] HMPREF9474_RS21970 acid aminotransferase: subunit alpha: glutaminase A: 23S rRNA HMPREF9474_RS16550 HMPREF9474_RS23240 HMPREF9474_RS07170 acetyl-CoA HMPREF9474_RS07170 pyrophosphohydrolase: RS08245 [+ 2 isozymes] val HMPREF9474_RS17435 (pentapeptide) L-alanine amidase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- formimionoglutamate HMPREF9474_RS01960 endodeoxyribonuclease thiamine phosphate [+ 6 isozymes] HMPREF9474_RS10250 HMPREF9474_RS14750 HMPREF9474_RS22760 HMPREF9474_RS04055 (adenine(2503)-C(2))- tryptophan synthase acetyltransferase: HMPREF9474_RS12460 asparaginyl/glutamyl-tRNA D-glucopyranose HMPREF9474_RS20505 acetoacetyl-CoA pyrophosphoryl- HMPREF9474_RS06175 phosphate acyltransferase: phosphate acyltransferase: hydrolase SpeB: phosphoadenosine RuvA: synthase: urocanate Glu methyltransferase RlmN: subunit beta: α HMPREF9474_RS17465 α an L-aspartyl- a N-acetylglucosamine- resolution of xanthosine RS20305 amidotransferase subunit F6P (S)-3-methyl-2- branched chain amino [+ 2 isozymes] HMPREF9474_RS00085 HMPREF9474_RS00085 HMPREF9474_RS17555 phosphosulfate reductase: 2-deoxy- - 2-deoxy- - HMPREF9474_RS16400 GMP 2-aminoprop- undecaprenol N- [+ 6 isozymes] Asx D-ala -N-acetylmuramyl- recombinationalHMPREF9474_RS04695 N-acetyl-D- RS07350 oxopentanoate acetyl-CoA HMPREF9474_RS21010 HMPREF9474_RS01855 UDP-N-acetyl-α-D- HMPREF9474_RS15750 D-ribose 1- D-ribose 1- [tRNA ] biotinyl-5'- C: HMPREF9474_RS09640 urocanate hydratase: acid aminotransferase: 2-enoate acetylglucosamine a purine base guanine (tetrapeptide) junction ala muramate glucokinase: acetyltransferase: D-ala muramoyl-L-alanyl- phosphate phosphate adenylate [+ 2 isozymes] phosphosugar isomerase: HMPREF9474_RS23550 HMPREF9474_RS22760 transferase: a peptidoglycan dimer L-alanyl-γ-D- D-glyceraldehyde 1-stearoyl-2- 1-stearoyl- β-ketovaleryl-CoA pyrophosphoryl- formation of two HMPREF9474_RS18700 HMPREF9474_RS03210 2503 γ-D-glutamyl-meso- thiamine HMPREF9474_RS03470 ditrans,octacis- HMPREF9474_RS18465 a 2-methyladenine with pentapeptide stem glutamyl-meso-2,6- oleoyl-sn-glycerol 2-palmitoyl- urea undecaprenol an L-glutaminyl- [+ 2 isozymes] 3-methyl-2-oxobutanoate acetyl-CoA UDP 5'-deoxyadenosine met 3-phosphate trp L-ornithine 2,6-diaminopimelate PAPS intact strands phosphate pro RS22475 pro Gln undecaprenyldiphospho- in 23S rRNA (meso-diaminopimelate diaminopimeloyl- 3-phosphate sn-glycerol [tRNA ] tRNA charging [+ 2 isozymes] 4-imidazolone- 2-methylbutanoyl- acetyltransferase: RS06705 N-acetyl-(N-acetyl-β-D- containing) D-alanyl-D-alanine 3-phosphate 5-propanoate CoA 2-iminopropanoate D-serine degradation HMPREF9474_RS17465 met RS09675 met imidazolonepropionase: glucosaminyl)muramoyl- S-2-methylbutryl- reactive intermediate/ γ asp asp acetyl-CoA L-alanyl- -D-glutamyl-L- tRNA D-glucopyranose HMPREF9474_RS01650 CoA:FAD oxidoreductase: Thr imine deaminase: lysyl-D-alanyl-D-alanine thr a tRNA imidazolonepropionase: HMPREF9474_RS17480 isobutanoyl-CoA D-serine met RS19330 met 6-phosphate HMPREF9474_RS18530 RS19025 phe a tRNA Phe HMPREF9474_RS20285 (E)-2- D-serine ammonia-lyase: elongator glucose-6-phosphate isobutyryl-CoA:FAD reactive intermediate/ Asn Val Ile ser Arg Pro Gln Lys aspartate--tRNA ligase: His Tyr Leu glu Gly Cys Trp Met methylcrotonoyl- asn tRNA val a tRNA ile a tRNA ser a tRNA arg a tRNA pro a tRNA gln a tRNA lys a tRNA his a tRNA tyr a tRNA leu a tRNA Glu a tRNA gly a tRNA cys a tRNA trp a tRNA Met met initiator tRNA met HMPREF9474_RS23260 an inactive 10 1-cis- 1-cis- 1-stearoyl- a diacylglycerol (S)-4-hydroxy- β-D-fructofuranose 5'-deoxy-5'- 5'-deoxy-5'- a [protein] N- tRNA Ala dehydrogenase: oxidoreductase: imine deaminase: 2-aminoprop- an L-methionyl- an N - a cis- a nucleoside a ribonucleoside an L-cysteinyl- HMPREF9474_RS15565 threonine--tRNA ligase: a tRNA ala N-formimino- CoA Inorganic Nutrient Metabolism ribonucleoside vaccenoylglycerol- a palmitoleoyl-[acp] vaccenoylglycerol- F6P sn-glycerol a stearoyl-[acp] prolipoprotein formate a protein terminal-formyl- N5-CAIR 3'-AMP SAM Met formyltetrahydrofolate 2-oxopentanoate RNA Cys 1-phosphate chloroadenosine fluoroadenosine RS10365 phenylalanine--tRNA ligase: aspartate-- HMPREF9474_RS07850 HMPREF9474_RS12445 L-glutamate enoyl-CoA hydratase: HMPREF9474_RS17480 HMPREF9474_RS14035 2-enoate [initiator tRNA ] vaccenoyl-[acp] triphosphate triphosphate [tRNA ] 2'-deoxyinosine IMP 6-phospho triphosphate 3-phosphate 3-phosphate 3-phosphate (with signal L-methionine 1-(5-phosphoribosyl)- multifunctional 2',3'- HMPREF9474_RS07970 asparagine--tRNA ligase: valine--tRNA ligase: isoleucine--tRNA ligase: serine--tRNA ligase: arginine--tRNA ligase: proline--tRNA ligase: glutamine--tRNA ligase: lysine--tRNA ligase: tRNA(Asn) ligase: histidine--tRNA ligase: tyrosine--tRNA ligase: threonine--tRNA ligase: leucine--tRNA ligase: glutamate--tRNA ligase: glycine--tRNA ligase: cysteine--tRNA ligase: tryptophan--tRNA ligase: methionine--tRNA ligase: methionine--tRNA ligase: HMPREF9474_RS22015 methylacrylyl-CoA phosphate acquisition reductase peptide) 5-amino-4-imidazole- multifunctional 2',3'- D-glucono- pyruvate fructose-6- 4-hydroxy-2- fructose-bisphosphate purine-nucleoside purine-nucleoside cyclic-nucleotide 2'- pheS HMPREF9474_RS22545 HMPREF9474_RS21155 HMPREF9474_RS21550 HMPREF9474_RS20975 HMPREF9474_RS19630 HMPREF9474_RS17035 HMPREF9474_RS14660 HMPREF9474_RS15170 HMPREF9474_RS09635 HMPREF9474_RS15570 HMPREF9474_RS14140 HMPREF9474_RS23820 HMPREF9474_RS08265 HMPREF9474_RS04105 HMPREF9474_RS04640 HMPREF9474_RS05485 HMPREF9474_RS00815 HMPREF9474_RS03690 HMPREF9474_RS03690 glutamate [+ 2 isozymes] DNA-directed ribonucleoside carboxylate carboxylase: cyclic-nucleotide 2'- RS05010 1,5-lactone (2S,3S)-3- methionyl-tRNA 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- phosphate aldolase: 1-acyl-sn-glycerol-3- oxovalerate aldolase: aminoacyl-tRNA hydrolase: aldolase: ATP-dependent Clp phosphorylase: phosphorylase: peptide deformylase: phosphodiesterase/ formiminotransferase: enoyl-CoA hydratase: RNA polymerase triphosphate reductase: purine-nucleoside HMPREF9474_RS16915 phosphodiesterase/ an L-methionyl- 6-phosphogluconolactonase: hydroxy-2- a phosphate anaerobic ribonucleoside- formyltransferase: phosphate acyltransferase: phosphate acyltransferase: HMPREF9474_RS22415 phosphate acyltransferase: signal peptidase II: HMPREF9474_RS07950 HMPREF9474_RS14095 HMPREF9474_RS01070 protease proteolytic: HMPREF9474_RS07170 HMPREF9474_RS07170 HMPREF9474_RS21030 5'-nucleotidase/ RS09680 an L-phenylalanyl- an L-asparaginyl- an L-valyl- an L-isoleucyl- an L-seryl- an L-arginyl- an L-prolyl- an L-glutaminyl- an L-lysyl- an L-aspartyl- an L-histidyl- an L-tyrosyl- an L-threonyl- an L-leucyl- an L-glutamyl- an L-cysteinyl- an L-tryptophanyl- an L-methionyl- an L-alanyl- HMPREF9474_RS17565 HMPREF9474_RS22015 2-iminopropanoate I subunit RPA12: HMPREF9474_RS19285 phosphorylase: 5'-nucleotidase/ Gly monoester triphosphate reductase HMPREF9474_RS21025 HMPREF9474_RS19650 HMPREF9474_RS19650 HMPREF9474_RS19650 HMPREF9474_RS20520 HMPREF9474_RS09095 peptide deformylase: 5-(carboxyamino)imidazole 3'-nucleotidase: Phe Asn Val Ile ser Arg Pro Gln Lys asp His Tyr Thr Leu Glu a glycyl-[tRNA ] Cys Trp [elongator Met Ala HMPREF9474_RS12455 methylbutanoyl- 3'-nucleotidase: [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [tRNA ] [initiator tRNA ] [tRNA ] [+ 2 isozymes] [+ 2 isozymes] acid phosphatase: fructose-6- 4-hydroxy-2- HMPREF9474_RS11895 [+ 2 isozymes] HMPREF9474_RS07170 [+ 3 isozymes] HMPREF9474_RS15685 ribonucleotide mutase: HMPREF9474_RS14750 tRNA Met ] 6-phosphogluconolactonase: CoA reactive intermediate/ activating protein: methionyl-tRNA 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- signal peptidase II: 5-chloro-5- 5-fluoro-5- HMPREF9474_RS16465 HMPREF9474_RS14750 (S)-3-hydroxy- HMPREF9474_RS13205 phosphate aldolase: oxovalerate aldolase: [+ 4 isozymes] HMPREF9474_RS08115 HMPREF9474_RS23215 HMPREF9474_RS12490 imine deaminase: HMPREF9474_RS22750 formyltransferase: phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: HMPREF9474_RS13875 deoxyribose deoxy-D-ribose isobutanoyl-CoA phosphate HMPREF9474_RS22925 HMPREF9474_RS17375 a 2'- cys a tRNA Cys 2-deoxy-α- adenine adenine adenosine inosine RS15340 D-gluconate 5-formimidoyltetrahydrofolate HMPREF9474_RS18530 [+ 2 isozymes] HMPREF9474_RS01365 HMPREF9474_RS00085 HMPREF9474_RS00085 HMPREF9474_RS00085 DHAP D-glyceraldehyde 1-phosphate 1-phosphate CAIR RS16735 Glu deoxyribonucleoside D-ribose 1- an N-terminal L- 6-phosphate reactive intermediate/ a cleaved an (S-diacyl- hypoxanthine formate formiminotransferase- D-glyceraldehyde RNA 5'-triphosphate phosphate methionyl-[protein] Carbohydrate Biosynthesis 2-methylacetoacetyl- imine deaminase: Aldehyde Degradation an active an N-formyl- 1-cis-vaccenoyl- 1,2-dicis- dihydroxyacetone 1-stearoyl-2- lipoprotein sn-glyceryl) a peptide a peptide cyclodeaminase: 3-phosphate acetaldehyde pyruvate CoA HMPREF9474_RS14035 5'-deoxyadenosine ribonucleoside L-methionyl- a tetrahydrofolate 2-palmitoleoyl vaccenoyl- stearoyl-sn signal peptide -L-cysteinyl- HMPREF9474_RS20280 (S)-3-hydroxy-isobutanoate L-threonine degradation IV met Amino Acid Biosynthesis gluconeogenesis I methylglyoxal degradation I triphosphate [initiator tRNA met ] phosphatidate phosphatidate -glycerol 3- [apolipoprotein] RS22655 RS13815 superpathway of L-tryptophan biosynthesis superpathway of L- UDP-N-acetyl-α-D- dTDP-L-rhamnose UDP-galactofuranose a 5,10- acetyl-CoA pyruvate superpathway of L- L-cysteine biosynthesis I L-histidine biosynthesis L-lysine biosynthesis III D-ribulose 3-hydroxyisobutyrate reductase phosphate isoleucine biosynthesis I mannosaminouronate biosynthesis I biosynthesis CO methenyltetrahydrofolate acetyltransferase: thr D-erythrose tyrosine biosynthesis 2 5-phosphate dehydrogenase: methylglyoxal phosphoenolpyruvate (S)-malate biosynthesis α HMPREF9474_RS03210 4-phosphate PRPP UDP-N-acetyl- -D- α bifunctional 5,10- HMPREF9474_RS19075 oxaloacetate D-erythrose UDP- -D-glucose ribulose-phosphate lactoylglutathione lyase: UDP-N-acetyl- decaprenyl-diphospho-N- 1-stearoyl- a long-chain a cytidine 1402 (S)-3- DNA with G- a (1->4)- ala ala phosphoenolpyruvate ser asp glucopyranose acetyl-CoA a nucleoside a lipopolysaccharide 37 α-D-glucosamine UDP-glucose 4-epimerase: methylene-tetrahydrofolate (S)-methylmalonate- HMPREF9474_RS02700 α-D-glucosamine a 2,3,4-saturated 2- a 2,3,4-saturated 1-palmitoylglycerol a purine L-canavanine a purine CO a cytidine 34 DMAPP an adenosine α 3'-GMP aspartate 4-phosphate serine acetyltransferase: aspartate kinase: UDP-N-acetyl 3-epimerase: acetyltransferase: amino acid lyase: acetylmuramoyl-pentapeptide diphosphocholine a palmitoyl-[acp] sn-glycerol fatty acyl-[acyl- in 16S rRNA lys 2'-deoxyadenosine hydroxyhexanoyl- a protein L-saccharopine A mismatch -D-glucan ITP RS05270 1-phosphate dehydrogenase/5,10- fatty acyl-[acp] 3-phosphate Ile2 in tRNA phospho-2-dehydro-3- aminotransferase: HMPREF9474_RS08905 glucose-1-phosphate HMPREF9474_RS07390 HMPREF9474_RS20990 semialdehyde L-arginine degradation III aldoketomutase: lysophosphatidate ribonucleoside 3-phosphate carrier protein] ribonucleoside 16S rRNA (cytosine(1402) in tRNA CoA glycogen- multifunctional 2',3'- RS05945 HMPREF9474_RS02835 glucosamine 2-epimerase: UDP-α-D-galactose methylene-tetrahydrofolate HMPREF9474_RS17465 HMPREF9474_RS14935 3-hydroxyacyl-CoA non-canonical purine gly gly deoxyheptonate aldolase: HMPREF9474_RS06510 phospho-2-dehydro-3- malate dehydrogenase: thymidylyltransferase: D-xylulose (arginine decarboxylase/ HMPREF9474_RS07915 -N(4))-methyltransferase: branching enzyme: cyclic-nucleotide 2'- RS19445 serine O-acetyltransferase: aspartate kinase: UDP-N-acetyl-αHMPREF9474_RS01285- cyclohydrolase: (R)-S- UDP-N-acetylglucosamine- LPS arginase: carbon monoxide dehydrogenase: A/G-specific adenine NTP pyrophosphatase: HMPREF9474_RS05005 deoxyheptonate aldolase: 1-(5-phospho- HMPREF9474_RS08075 HMPREF9474_RS08475 UDP-galactopyranose 5-phosphate agmatinase pathway) HMPREF9474_RS19480 tRNA(Ile)-lysidine tRNA (adenosine(37)-N6) saccharopine HMPREF9474_RS18375 phosphodiesterase/ [+ 2 isozymes] HMPREF9474_RS02805 HMPREF9474_RS17735 D-mannosamine HMPREF9474_RS23415 acetaldehyde lactoylglutathione -N-acetylmuramyl- cholinephosphotransferase: 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- HMPREF9474_RS00470 dehydrogenase HMPREF9474_RS03205 GPR endopeptidase: glycosylase: HMPREF9474_RS14520 3-deoxy-7- HMPREF9474_RS05005 O-acetyl-L-serine β-D-ribosyl)-ATP L-aspartyl- glucose-1-phosphate mutase: acetyl-CoA propanoyl-CoA gly phosphate acyltransferase: inosine-uridine nucleoside phosphate acyltransferase: purine-nucleoside 16S rRNA (cytosine(1402) synthetase: purine-nucleoside -dimethylallyltransferase dehydrogenase: glycogen- 5'-nucleotidase/ asp UDP-N-acetyl-D- [+ 2 isozymes] arg (pentapeptide) HMPREF9474_RS01920 phosphate acyltransferase: large subunit: 3-hydroxybutyryl- HMPREF9474_RS04880 HMPREF9474_RS10255 phosphoheptulonate 4-phosphate oxaloacetate thymidylyltransferase: HMPREF9474_RS01925 HMPREF9474_RS19650 N-ribohydrolase: HMPREF9474_RS00085 SpeB arginase/agmatinase/ phosphorylase: -N(4))-methyltransferase: HMPREF9474_RS22670 phosphorylase: MiaA: HMPREF9474_RS18850 branching enzyme: 3'-nucleotidase: [+ 2 isozymes] 3-deoxy-7- 10 (S)-3-amino-2- bifunctional pyrophosphoryl- HMPREF9474_RS19650 HMPREF9474_RS07735 synthase: cysteine synthase A: mannosaminuronic HMPREF9474_RS17325 an N - hydrogencarbonate arginine decarboxylase: LPS HMPREF9474_RS14560 formimionoglutamate HMPREF9474_RS07170 HMPREF9474_RS11240 HMPREF9474_RS07170 CoA dehydrogenase: HMPREF9474_RS20615 HMPREF9474_RS02820 IMP RS04090 aspartate kinase: phosphoheptulonate aspartate-semialdehyde α UDP-Galf methylpropanoate acetaldehyde-CoA/ undecaprenol N- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- an N 4 - α HMPREF9474_RS14750 RS15700 HMPREF9474_RS03920 HMPREF9474_RS18755 pyruvate acid dehydrogenase: dTDP- -D-glucose formyltetrahydrofolate HMPREF9474_RS18830 cholinephosphotransferase: hydrolase SpeB: HMPREF9474_RS17475 an apyrimidinic a (1,6)- -D- HMPREF9474_RS02835 synthase: D-glyceraldehyde acetylglucosamine 1402 34 3-oxohexanoyl- 1-(5-phospho-β- dehydrogenase: phosphoenolpyruvate HMPREF9474_RS01340 alcohol dehydrogenase: agmatine (R)-lactate HMPREF9474_RS01540 phosphate acyltransferase: phosphate acyltransferase: phosphate acyltransferase: HMPREF9474_RS17555 a reduced methylcytidine a lysidine glucosyl-(1,4) dTDP-glucose acetyl phosphate α + 2-deoxy-α- 6 a peptide a peptide allysine adenine site in DNA guanosine aspartate kinase: HMPREF9474_RS03920 cysteine synthase A: HMPREF9474_RS07130 carboxykinase: 3-phosphate HMPREF9474_RS11930 transferase: HMPREF9474_RS00085 HMPREF9474_RS00085 HMPREF9474_RS19650 -D-ribose- CO H in 16S rRNA Ile2 CoA N -(3-methylbut- Glu α 3-deoxy-D-arabino- D-ribosyl)-AMP UDP-N-acetyl-α-D- glycine cleavage D-ribofuranose 2 ferredoxin [iron- in tRNA - -glucan HMPREF9474_RS19430 4,6-dehydratase: HMPREF9474_RS18465 1-phosphate D-ribose 1- 2-en-1-yl)- heptulosonate HMPREF9474_RS17735 L-aspartate- HMPREF9474_RS18975 mannosaminuronate type I glyceraldehyde-3- [+ 2 isozymes] agmatinase: a purine base a purine base sulfur] cluster adenine 3-deoxy-D-arabino- HMPREF9474_RS08480 phosphate a [glycine-cleavage a phosphorylcholine- phosphate adenosine 37 7-phosphate semialdehyde phosphate dehydrogenase: HMPREF9474_RS18845 a nucleoside 5'- a 1-stearoyl 2- urea RS12350 RS21910 L-aspartyl- heptulosonate cys dTDP-glucose PRPP biosynthesis I acetyltransferase: complex H protein] N 6 L-citrulline degradation acetyl-CoA 6-O-hexose- a 2,3,4-saturated 1,2-diacyl- dipalmitoyl L-canaline in tRNA phosphoenol HMPREF9474_RS04950 SpeB arginase/agmatinase/ decaprenyl-pyrophosphoryl- UDP monophosphate acyl-sn-glycerol 3-dehydroquinate synthase: 4-phosphate 7-phosphate 1-(5-phospho-β-D-ribosyl)- dihydrodipicolinate 4,6-dehydratase: HMPREF9474_RS06990 -[(R)-lipoyl]-L-lysine glycine dehydrogenase pyruvate lipopolysaccharide sn-glycerol 3-phosphate phosphatidate pyruvate formimionoglutamate (N-acetylglucosamine)-N- 3-phosphate HMPREF9474_RS20525 3-dehydroquinate synthase: 5-[(5-phosphoribosylamino) synthase family protein: HMPREF9474_RS17330 D-ribose 5- 13-DPG subunit 1: aspartate-semialdehyde enolase: acetyl-CoA L-citrulline L-asparagine hydrolase SpeB: acetylmuramyl-(pentapeptide) HMPREF9474_RS20525 methylideneamino]imidazole- HMPREF9474_RS03350 phosphate HMPREF9474_RS02315 3-dehydroquinate dehydrogenase: HMPREF9474_RS18175 dTDP-4-dehydro- phosphoribosylpyrophosphate dihydrolipoyl ornithine degradation I HMPREF9474_RS17555 4-carboxamide α phosphoglycerate RS13490 HMPREF9474_RS07130 [+ 2 isozymes] 6-deoxy- -D- synthetase: bifunctional dehydrogenase: glycine dehydrogenase: carbamoyltransferase: α 3-dehydroquinate (2S,4S)-4- phosphopyruvate kinase: pgk L-glutamate UDP-N-acetyl-α-D-glucosamine undecaprenyl-diphospho-N di-trans,octa-cis UDP- -D- a 1-alkyl-sn 1-oleyl-2-lyso- a (1->4)- a [protein]-L- RS07090 3-dehydroquinase: glucopyranose HMPREF9474_RS22460 acetaldehyde-CoA/ HMPREF9474_RS08970 HMPREF9474_RS02310 putrescine 1-palmitoylglycerol ethylnitronate FMN NAD(P)H H + glycerophosphoserine HMG-CoA a reduced a RNA-DNA hybrid a nucleoside an acetic ester AMP L-aspartate- hydroxy-2,3,4,5- hydratase: eno carbamoylHMPREF9474_RS07420 degradation I asn -acetylmuramoyl-L-alanyl-γ- -undecaprenyl galactose a myristoyl-[acp] pyruvate -glycerol 3- phosphatidate α-D-glucan a protein tRNA Asn asp methionine ser HMPREF9474_RS22435 dTDP-4-dehydrorhamnose phosphoribosylpyrophosphate 3-phospho- alcohol dehydrogenase: L-asparaginase 1: 3-phosphate dGTP rubredoxin superoxide triphosphate semialdehyde 3-dehydroquinase: tetrahydrodipicolinate 2-phospho- phosphate D-glutamyl-L-lysyl- D-alanine phosphate phosphate 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- nucleotide peptide-methionine multifunctional 2',3'- [+ 2 isozymes] 3,5-epimerase: synthetase: D-glycerate HMPREF9474_RS11930 HMPREF9474_RS17795 L-serine dehydratase, homoserine HMPREF9474_RS22435 phosphoribulosylformimino- 4-hydroxy- D-glycerate a [glycine-cleavage Glu phosphate acyltransferase: phosphate acyltransferase: pyrophosphohydrolase: (R)-S-oxide reductase: cyclic-nucleotide 2'- HMPREF9474_RS01875 HMPREF9474_RS20800 [+ 2 isozymes] a [glycine-cleavage UDP-N-acetylglucosamine- 2-nitropropane old Yellow Enzyme glycerophosphoryl diester hydroxymethylglutaryl- alpha-amylase: pectin acetylesterase: iron-sulfur-dependent RS20335 [+ 2 isozymes] AICAR-phosphate tetrahydrodipicolinate 6 L-asparaginase: HMPREF9474_RS19650 ribonuclease HII: HMPREF9474_RS12460 HMPREF9474_RS21170 phosphodiesterase/ 3-dehydroshikimate dehydrogenase: 2,3-bisphosphoglycerate- dTDP-4-dehydro- 6 complex H protein] N - glutamate UDP-phosphate galactose 1-acyl-sn-glycerol-3- HMPREF9474_RS00085 HMPREF9474_RS02480 superoxide reductase: beta-aspartyl-peptidase: aspartate-- subunit alpha: PRPP complex H protein] N HMPREF9474_RS15915 -N-acetylmuramyl- dioxygenase: family NADH:flavin phosphodiesterase: CoA lyase: 1-acyl-sn-glycerol-3- HMPREF9474_RS09790 HMPREF9474_RS19575 peptide-methionine 5'-nucleotidase/ RS23445 HMPREF9474_RS17730 3-dehydroshikimate reductase: independent β-L-rhamnose acetaldehyde aminomethyldihydrolipoyl- dehydrogenase: L-glutamate degradation X phosphotransferase: phosphate acyltransferase: pyruvate kinase: 1-acyl-sn-glycerol-3- alpha-amylase: HMPREF9474_RS08220 HMPREF9474_RS09660 nucleotide tRNA(Asn) ligase: HMPREF9474_RS20505 superpathway of branched chain amino acid biosynthesis -dihydrolipoyl-L-lysine asp (pentapeptide) HMPREF9474_RS03770 oxidoreductase: HMPREF9474_RS17610 HMPREF9474_RS18805 phosphate acyltransferase: acetylhydrolase: (R)-S-oxide reductase: 3'-nucleotidase: shikimate dehydrogenase: HMPREF9474_RS21330 phosphoglycerate mutase: 2-phospho- L-lysine CO gdh HMPREF9474_RS04855 HMPREF9474_RS19650 HMPREF9474_RS05080 phosphate acyltransferase: HMPREF9474_RS18380 desulfoferrodoxin: beta-aspartyl-peptidase: pyrophosphohydrolase: HMPREF9474_RS09635 dTDP-4-dehydrorhamnose alcohol dehydrogenase: 2 pyrophosphoryl- 2-nitropropane HMPREF9474_RS21290 glycerophosphoryl diester 3-hydroxy-3- HMPREF9474_RS23450 [+ 2 isozymes] HMPREF9474_RS18815 L-homoserine (S)-2,3,4,5- HMPREF9474_RS04925 D-glycerate HMPREF9474_RS00085 HMPREF9474_RS22635 HMPREF9474_RS10720 HMPREF9474_RS14750 ala RS04010 ala shikimate dehydrogenase: reductase: Aromatic Compound HMPREF9474_RS03355 [+ 2 isozymes] undecaprenol N- UDP-phosphate galactose 1-acyl-sn-glycerol-3- dioxygenase: [+ 3 isozymes] phosphodiesterase: methylglutaryl-CoA lyase: a 2-acyl-1-alkyl-HMPREF9474_RS19650 dioleoyl HMPREF9474_RS04385 a nucleoside 5'- HMPREF9474_RS02405 a protein-L- pyruvate shikimate dehydrogenase: HMPREF9474_RS18815 pyruvate D-erythro- tetrahydrodipicolinate cofactor-independent glycogen biosynthesis I (from ADP-D-Glucose) enolase: 2-oxoglutarate Glu phosphotransferase: phosphate acyltransferase: DNA a nucleoside 5'- methionine- thr HMPREF9474_RS17335 Biosynthesis [+ 6 isozymes] acetylglucosamine HMPREF9474_RS03810 HMPREF9474_RS03990 HMPREF9474_RS13775 sn-glycerol phosphatidate a (1->4)- monophosphate an L-aspartyl- adenosine HMPREF9474_RS19615 AICAR imidazole-glycerol- phosphoglycerate mutase: HMPREF9474_RS18175 glutamate dehydrogenase: HMPREF9474_RS08490 HMPREF9474_RS00085 maltohexaose monophosphate (R)-S-oxide shikimate dehydrogenase: dTDP-β-L- L-glutamine transferase: phosphoenolpyruvate 3-phosphate α-D-glucan Asn acetate an alcohol acetolactate synthase, phosphate D-glucopyranose HMPREF9474_RS18795 dGDP an oxidized [tRNA ] RS08455 RS17280 HMPREF9474_RS19615 serine/threonine L-arginine biosynthesis I (via L-ornithine) HMPREF9474_RS20965 rhamnose 4-aminobenzoate phosphopyruvate ethanol degradation II L-aspartate degradation I HMPREF9474_RS18465 FMNH NAD(P) + a protein asp shikimate large subunit, 6-phosphate L-alanine degradation IV [unspecified 2 rubredoxin dehydratase: 3-phospho- biosynthesis hydratase: eno glutamate dehydrogenase: α-D-galactosyl- acetaldehyde nitrite sn-glycerol acetoacetate acetyl-CoA O-phospho- biosynthetic type: α ε UMP 1-palmitoyl-2-myristoyl degradation ser shikimate HMPREF9474_RS23520 L- -amino- - phosphoglucomutase: phosphoenol HMPREF9474_RS18585 ditrans,octacis-undecaprenyldiphospho- UDP diphosphoundecaprenol 3-phosphate shikimate kinase: L-homoserine HMPREF9474_RS05390 D-glycerate gln 2-oxoglutarate phosphatidate products] [+ 2 isozymes] Glu keto-pimelate HMPREF9474_RS17085 chorismate pyruvate asp N-acetyl-(N-acetylglucosaminyl)muramoyl- HMPREF9474_RS18745 [+ 6 isozymes] imidazole acetol- phosphoglycerate glutamate ala γ threonine synthase: shikimate kinase: diaminopimelate α-D- aminodeoxychorismate/ aspartate aminotransferase: L-alanyl- -D-glutamyl-L-lysyl-D-alanine RS02075 HMPREF9474_RS18745 (2Z)-2-aminobut- phosphate N-acetylglutamate kinase: pgk anthranilate synthase pyruvate kinase: synthase (NADPH): alanine dehydrogenase: RS21495 HMPREF9474_RS15850 2-enoate (S)-2-acetolactate dehydrogenase: glucopyranose HMPREF9474_RS06510 shikimate 3-phosphate histidinol-phosphate synthase: component II: HMPREF9474_RS05080 HMPREF9474_RS04325 HMPREF9474_RS12750 HMPREF9474_RS21115 1-phosphate Glu [+ 2 isozymes] a [formate C a pentaglycine cross- an N-formyl-L- a single- quinoxaline-2- MoO - a ribonucleoside UTP shikimate 3-phosphate aminotransferase: HMPREF9474_RS07435 13-DPG HMPREF9474_RS01835 oxaloacetate pyruvate a protein with 1-palmitoylglycerol ATP H O glycerophosphoglycerol an acyl-CoA H O 3'-ketolactose a ribonucleoside 2 a ribonucleoside (S)-citramalate NMN α-amylose thr ketol-acid glucose-1-phosphate a reduced flavodoxin SAM a palmitoleoyl-[acp] 2 KDGP methionylaminoacyl- pyruvate 2 molybdopterin 2',3'-cyclic 3-phosphoshikimate 1- meso- 4-amino-4- pyruvate acetyltransferase]-glycine bridge of peptidoglycan dATP stranded RNA carboxyl adenylate 5'-monophosphate ATP 3'-phosphate nucleotide reductoisomerase: HMPREF9474_RS04820 N-acetyl-L- triose- type I glyceraldehyde-3- adenylyltransferase: NXTN motif 3-phosphate tRNA cofactor phosphate multifunctional 2',3'- glycogen- carboxyvinyltransferase: 3-phosphoshikimate 1- diaminopimelate deoxychorismate multifunctional 2',3'- multifunctional 2',3'- multifunctional 2',3'- pyrophosphohydrolase: RS19460 HMPREF9474_RS18885 L-histidinol- glutamate phosphate phosphate dehydrogenase: HMPREF9474_RS22555 UDP-N-acetyl-D- cyclic-nucleotide 2'- branching enzyme: HMPREF9474_RS03930 serine/threonine carboxyvinyltransferase: 2-iminobutanoate polyribonucleotide beta-galactosidase: cyclic-nucleotide 2'- cyclic-nucleotide 2'- cyclic-nucleotide 2'- HMPREF9474_RS22635 (2R)-2,3- phosphate diaminopimelate isomerase: HMPREF9474_RS04950 glucosamine biosynthesis I lactate dehydrogenase: pyruvate formate-lyase class C sortase: nucleotide 2-dehydro-3-deoxy- glycerophosphoryl diester acyl-CoA thioesterase: acyl carrier protein: isopropylmalate/ phosphodiesterase/ HMPREF9474_RS02820 RS07525 5-enolpyruvoyl- dehydratase: HMPREF9474_RS03930 acetyl-L-glutamate 5- glucose-1-phosphate Alcohol Degradation 1-acyl-sn-glycerol-3- peptide deformylase: nucleotidyltransferase: HMPREF9474_RS02900 phosphodiesterase/ MobA/MobL protein: phosphodiesterase/ phosphodiesterase/ dihydroxy-3- decarboxylase: tpiA HMPREF9474_RS06335 1-activating enzyme: HMPREF9474_RS02550 pyrophosphohydrolase: phosphogluconate phosphodiesterase: HMPREF9474_RS01725 HMPREF9474_RS03815 homocitrate/ 5'-nucleotidase/ glycogen- nucleotide shikimate 3-phosphate HMPREF9474_RS23520 reactive intermediate/ phosphotransferase: D-glyceraldehyde adenylyltransferase D-glucopyranose phosphate acyltransferase: HMPREF9474_RS21030 pyruvate kinase: HMPREF9474_RS04135 beta-galactosidase: 5'-nucleotidase/ HMPREF9474_RS14865 5'-nucleotidase/ 5'-nucleotidase/ 5-enolpyruvoyl- methylbutanoate histidinol-phosphatase: HMPREF9474_RS05075 DHAP [+ 2 isozymes] HMPREF9474_RS17755 HMPREF9474_RS12460 aldolase: HMPREF9474_RS03990 acyl carrier protein: citramalate synthase: 3'-nucleotidase: branching enzyme: pyrophosphohydrolase: [+ 2 isozymes] imine deaminase: HMPREF9474_RS18865 3-phosphate subunit GlgD: 6-phosphate 4-aminobenzoate (R)-lactate class B sortase: HMPREF9474_RS19650 peptide deformylase: HMPREF9474_RS05080 HMPREF9474_RS03610 3'-nucleotidase: MobA/MobL family protein: 3'-nucleotidase: 3'-nucleotidase: RS11530 chorismate synthase: shikimate 3-phosphate dihydroxy-acid HMPREF9474_RS12265 phosphosugar isomerase: glycerol and glycerophosphodiester degradation nucleotide HMPREF9474_RS22620 glycerophosphoryl diester HMPREF9474_RS06950 HMPREF9474_RS08430 HMPREF9474_RS14750 HMPREF9474_RS18375 HMPREF9474_RS12460 (2Z)-2-aminobut- HMPREF9474_RS18530 lys HMPREF9474_RS22560 ethanol degradation I pyruvate formate lyase- HMPREF9474_RS02540 1-acyl-sn-glycerol-3- HMPREF9474_RS16465 HMPREF9474_RS14750 HMPREF9474_RS03715 HMPREF9474_RS14750 HMPREF9474_RS14750 β HMPREF9474_RS12485 dehydratase: acetylglutamate kinase: HMPREF9474_RS03470 pyrophosphohydrolase: phosphodiesterase: a single- 1-( -D UMP 2-enoate chorismate synthase: reactive intermediate/ histidinol a (1->4)- (S)-lactate activating protein: phosphate acyltransferase: a nucleoside a carboxylate β a ribonucleoside a ribonucleoside a ribonucleoside amylopectin HMPREF9474_RS13960 HMPREF9474_RS07430 ADP-α-D-glucose [+ 2 isozymes] Amine and Polyamine Degradation a protein with NPXT HMPREF9474_RS22635 HMPREF9474_RS17610 stranded RNA 3-keto- -D- a quinoxaline-2- ribofuranosyl) RS20585 gln HMPREF9474_RS12485 imine deaminase: α-D-glucan a glycerophosphodiester HMPREF9474_RS01085 a peptide with an N- HMPREF9474_RS00085 D-glyceraldehyde diphosphate D-glucopyranose adenylyl 3'-phosphate acetate pyruvate chorismate 3-methyl-2- N-acetylglutamyl- F6P ethanol carboxyl end attached pyruvate a L-methionylaminoacyl- phosphoenolpyruvate galactose AMP carboxyl-[aryl- nicotinamide HMPREF9474_RS14035 histidinol dehydrogenase: fructose-bisphosphate alcohol dehydrogenase: terminal L-asparagine 3-phosphate formate dADP molybdenum chorismate oxobutanoate phosphate aldolase: starch synthase: homolactic fermentation 4-aminobutanoate degradation V to a pentaglycine cross- tRNA carrier protein] RS22525 HMPREF9474_RS15495 glutamine--fructose- a [formate C acetyltransferase]- + sn-glycerol cofactor 2-oxobutanoate HMPREF9474_RS13195 superpathway of N-acetylglucosamine, urea degradation I glycerophosphoryl diester HMPREF9474_RS03355 5'-deoxyadenosine bridge of peptidoglycan 1-palmitoyl-2-palmitoleoyl AMP diphosphate H glycerol anthranilate synthase N-acetyl-gamma-glutamyl- HMPREF9474_RS01070 6-phosphate a flavodoxin semiquinone glycin -2-yl radical met 3-phosphate 2-iminobutanoate bifunctional chorismate isopropylmalate/ branched chain amino superpathway of L- N-acetylmannosamine and N- phosphodiesterase: glycerol [+ 6 isozymes] phosphatidate component I: histidinal phosphate reductase: [+ 4 isozymes] a (1->4)- aminotransferase: D-glucopyranose acetaldehyde mutase/prephenate acetolactate synthase, homocitrate/ acid aminotransferase: threonine biosynthesis 4-aminobutanoate acetylneuraminate degradation urea HMPREF9474_RS17610 RS11430 HMPREF9474_RS01830 reactive intermediate/ HMPREF9474_RS07440 α-D-glucan HMPREF9474_RS09625 dehydratase: large subunit, citramalate synthase: HMPREF9474_RS22760 histidinol dehydrogenase: N-acetyl-L- glycerophosphoryl diester glycerol imine deaminase: glucokinase: N-acetylneuraminate bifunctional 38- RS18325 oxaloacetate glycogen- D-glucosamine a [ribosomal a 2'- sn-glycero-3- (S)-3- a (1->4)- (11Z)-(S)-3- a uridine N 2 - a [protein]-L- a (1->4)- dTTP HMPREF9474_RS00080 biosynthetic type: HMPREF9474_RS08430 HMPREF9474_RS15495 glutamate 5- HMPREF9474_RS18700 N-acetylneuraminate lyase: phosphodiesterase: kinase: a sulfurated a peptidoglycan 1-myristoylglycerol a peptide with a an acyl- palmitoyl-CoA H O lauroyl-CoA H O glycocholate acetylxylan oxaloacetate HMPREF9474_RS18530 acetaldehyde-CoA/ protein S12] deoxyribonucleoside 2 hydroxytetradecanoyl- 2 α-D-glucan hydroxyhexadec- ω α anthranilate HMPREF9474_RS05390 aspartate branching enzyme: 6-phosphate HMPREF9474_RS03990 glpK a myristoyl-[acp] [DNA] phosphoethanolamine coenzyme A 40 in tRNA succinylglutamate proline ( = 180) -D-glucan [+ 2 isozymes] semialdehyde fructose 1,6- HMPREF9474_RS15515 [sulfur carrier] 89 3-phosphate leader sequence carrier protein glycogen- nucleotide reactive intermediate/ prephenate val aminotransferase: HMPREF9474_RS18375 phosphoglucosamine D-glucopyranose N-acetyl-D- urea-1-carboxylate alcohol dehydrogenase: L-aspartate 5'-triphosphate CoA 11-enoyl-CoA tRNA pseudouridine(38- peptidyl-prolyl cis- oxaloacetate [+ 6 isozymes] his acetylornithine bisphosphate 3-hydroxyacyl-CoA 3-hydroxyacyl-CoA branching enzyme: pyrophosphohydrolase: anthranilate imine deaminase: HMPREF9474_RS06510 glycogen- mutase: 6-phosphate succinate mannosamine HMPREF9474_RS11930 glycosyl transferase 40) synthase TruA: trans isomerase: decarboxylase: prephenate (S)-2-aceto-2- (2S)-2- aminotransferase: Glu allophanate hydrolase: sn-glycerol N-acetylmuramoyl- glycerophosphoryl diester acyl-CoA thioester dehydrogenase: dehydrogenase: succinylglutamate acetylxylan esterase: HMPREF9474_RS18375 HMPREF9474_RS22635 RS02945 phosphoribosyltransferase: HMPREF9474_RS14035 fructose-1,6- branching enzyme: HMPREF9474_RS17340 semialdehyde [+ 2 isozymes] 1-acyl-sn-glycerol-3- reverse transcriptase: holo-[acyl-carrier- acyl-CoA thioesterase: family 35: HMPREF9474_RS02080 HMPREF9474_RS09405 choloylglycine hydrolase: HMPREF9474_RS09060 RS03040 dehydrogenase: hydroxybutanoate isopropylmalate HMPREF9474_RS07425 [+ 2 isozymes] phosphosugar isomerase: creatinine degradation I HMPREF9474_RS02045 3-phosphate ribosomal protein S12 L-alanine amidase: signal peptidase I: phosphodiesterase: hydrolase: HMPREF9474_RS03205 HMPREF9474_RS03205 desuccinylase: HMPREF9474_RS23355 nucleotide HMPREF9474_RS01840 hydrogencarbonate bisphosphatase: HMPREF9474_RS02820 D-glucosamine HMPREF9474_RS03470 4-hydroxybutyrate methylthiotransferase HMPREF9474_RS06175 phosphate acyltransferase: HMPREF9474_RS11960 HMPREF9474_RS11380 protein] synthase: HMPREF9474_RS01725 HMPREF9474_RS21555 tRNA pseudouridine(38- peptidyl-prolyl cis- HMPREF9474_RS11225 oxaloacetate glycogen- 2-oxobutanoate HMPREF9474_RS03925 ketol-acid 3-isopropylmalate N-acetyl-L- asp glutamate allophanate hydrolase: acetyl-CoA HMPREF9474_RS17610 HMPREF9474_RS05690 3-hydroxybutyryl- 3-hydroxybutyryl- HMPREF9474_RS09150 acetylxylan esterase: pyrophosphohydrolase: N-(5-phosphoribosyl) HMPREF9474_RS07100 1-phosphate [+ 2 isozymes] dehydrogenase: RimO: HMPREF9474_RS19650 RNA-directed [+ 2 isozymes] HMPREF9474_RS21475 40) synthase TruA: trans isomerase: decarboxylase: branching enzyme: reductoisomerase: dehydratase: carbamoyl phosphate ornithine a glycogen dehydrogenase: N-acetyl-D- creatinine HMPREF9474_RS02050 [+ 6 isozymes] glycerophosphoryl diester acyl-CoA thioesterase: CoA dehydrogenase: CoA dehydrogenase: [+ 3 isozymes] HMPREF9474_RS20950 HMPREF9474_RS02820 HMPREF9474_RS12460 -anthranilate 4-hydroxyphenylpyruvate aspartate kinase: fructose 1,6- HMPREF9474_RS18735 HMPREF9474_RS20870 1-acyl-sn-glycerol-3- DNA polymerase: a (1->4)- α-D- HMPREF9474_RS14815 HMPREF9474_RS01455 HMPREF9474_RS14675 acetolactate synthase, HMPREF9474_RS18885 HMPREF9474_RS18920 L-methionine biosynthesis III synthase large subunit: gdh mannosamine phosphodiesterase: HMPREF9474_RS01725 HMPREF9474_RS17475 HMPREF9474_RS17475 a pseudouridine 38- a [protein]-L- N-(5'-phosphoribosyl) bisphosphatase: F6P 4-hydroxybutyrate creatinine amidohydrolase: ammonium HMPREF9474_RS21875 3-oxo- laurate α (11Z)-3-oxo- cholate pyruvate starch dTMP RS13170 large subunit, leuD HMPREF9474_RS00780 HMPREF9474_RS02835 6-phosphate ditrans,octacis- phosphate acyltransferase: HMPREF9474_RS03990 -D-glucan glucopyranose 40 in tRNA proline (ω = 0) gly RS11100 anthranilate isomerase: (R)-2,3-dihydroxy- HMPREF9474_RS14010 [+ 2 isozymes] dehydrogenase: N-acetylmannosamine-6- HMPREF9474_RS12345 DHAP a peptidoglycan 3',5'-ADP myristoyl-CoA hexadecenoyl-CoA acetate xylan biosynthetic type: aspartate kinase: N-acetyl-α-D- 6-phosphofructokinase: a [ribosomal undecaprenyldiphospho- HMPREF9474_RS00085 a leader sequence a peptide 1-phosphate succinate HMPREF9474_RS01850 3-methylpentanoate [+ 2 isozymes] HMPREF9474_RS04540 phosphate 2-epimerase: 5'-deoxyadenosine an unsulfurated pentapeptide Glu HMPREF9474_RS05390 2-isopropylmaleate L-homoserine HMPREF9474_RS17735 F6P glucosamine HMPREF9474_RS15150 ammonium creatine met protein S12]-3- N-acetyl-(N- palmitate 1-(o- dihydroxy-acid carbamoyl HMPREF9474_RS15555 ethanolamine utilization methylsulfanyl- [sulfur carrier] [DNA] sn-glycerol [+ 6 isozymes] L-ornithine 1-phosphate [+ 4 isozymes] 4-hydroxybutanoate acetylglucosaminyl)muramate dimyristoyl ethanolamine carboxyphenylamino) tyr dehydratase: 3-isopropylmalate phosphate L-aspartyl- N-acetyl-D- 89 (S)-2-aceto-2- phosphosugar isomerase: UDP-N-acetylglucosamine fructose 1,6- L-aspartate phosphatidate 3-phosphate RS21100 -1'-deoxyribulose HMPREF9474_RS13960 dehydratase: 4-phosphate HMPREF9474_RS03470 glucosamine ethanolamine RS06040 hydroxybutanoate pyrophosphorylase: bisphosphate 6-phosphate 5'-phosphate (S)-3-methyl-2- HMPREF9474_RS18920 ornithine aspartate-semialdehyde [+ 2 isozymes] 4-hydroxybutyrate allantoin degradation ethanolamine ketol-acid leuD HMPREF9474_RS07110 N-acetylglucosamine-6- indole-3-glycerol- oxopentanoate O-acetyl-L- carbamoyltransferase: dehydrogenase: D-glucopyranose CoA-transferase: sarcosine to glyoxylate I ammonia-lyase: a peptide with uridine 2'3'-cyclic adenosine N-acetyl-D- a SpoIVB reductoisomerase: UDP-N-acetyl- fructose-bisphosphate phosphate deacetylase: 34 H O 1-myristoylglycerol a peptidoglycan an N-acylated- L,L- a 3-oxoglutaryl- 2-phosphoglycolate citrate tributyrin (R)-NADPHX 3'-cmp phosphate synthase: branched chain amino (2R,3S)-3- homoserine hydrogen sulfide a 5,10-gly a uridine 2 'activated' tRNA phosphate monophosphate 2',3'-cyclic galactosamine HMPREF9474_RS18885 HMPREF9474_RS07420 HMPREF9474_RS07130 6-phosphate α-D-glucosamine aldolase: HMPREF9474_RS04520 HMPREF9474_RS12590 GTP a palmitoleoyl-[acp] cys an N-terminal butanoyl-CoA [acp] methyl ester a protein peptidase HMPREF9474_RS01845 acid aminotransferase: isopropylmalate HMPREF9474_RS12655 (S)-(+)-allantoin acetaldehyde methylenetetrahydrofolate in tRNA 3-phosphate D-amino acid diaminopimelate phosphoglycolate multifunctional 2',3'- monophosphate 6-phosphate multifunctional 2',3'- RS17200 L-proline biosynthesis I L-aspartate- HMPREF9474_RS01070 Xaa-L-proline diaminopimelate 3-oxoacyl-ACP reductase: multifunctional 2',3'- bifunctional ADP- Precursor (R)-2,3-dihydroxy- HMPREF9474_RS22760 D-glucosamine allantoinase: phosphatase: cyclic-nucleotide 2'- cyclic-nucleotide 2'- (1S,2R)-1-C-(indol-3- 3-isopropylmalate O-acetylhomoserine semialdehyde 4-hydroxybutanoyl- glycoside aminotransferase: HMPREF9474_RS17535 cyclic-nucleotide 2'- dependent (S)- SpoIVB peptidase: RS12280 3-methylpentanoate L-citrulline Metabolic Regulator [+ 4 isozymes] acetate 6-phosphate HMPREF9474_RS05050 acetobutylicum HMPREF9474_RS18980 citrate lyase subunit alpha: triacylglycerol lipase: phosphodiesterase/ phosphodiesterase/ yl)glycerol 3-phosphate dehydrogenase: aminocarboxypropyltransferase: CoA tRNA uridine-5- ribosome biogenesis 1-acyl-sn-glycerol-3- tRNA 4-thiouridine(8) hydrolase family 25: leucyl aminopeptidase: HMPREF9474_RS14805 beta-ketoacyl- phosphodiesterase/ N-acetylglucosamine-6- NAD(P)H-hydrate HMPREF9474_RS13185 dihydroxy-acid Glu ile homoserine Biosynthesis phosphotransbutyrylase: D-aminoacylase: HMPREF9474_RS17100 HMPREF9474_RS05785 endopeptidase La: 5'-nucleotidase/ 5'-nucleotidase/ tryptophan synthase HMPREF9474_RS13955 HMPREF9474_RS06870 4-hydroxybutyryl- allantoate carboxymethylaminomethyl(34) GTPase YlqF: phosphate acyltransferase: synthase ThiI: HMPREF9474_RS04625 HMPREF9474_RS05605 ACP reductase: phosphoglycolate 5'-nucleotidase/ phosphate deacetylase: dehydratase/NAD(P) dehydratase: glutamate 5-kinase: dehydrogenase: gly synthesis: HMPREF9474_RS14810 HMPREF9474_RS18525 LL-diaminopimelate phosphatase: [+ 8 isozymes] HMPREF9474_RS08105 3'-nucleotidase: H-hydrate epimerase: 3'-nucleotidase: a SpoIVB RS08580 subunit beta: (2S)-2-isopropyl- argininosuccinate synthase: ppGpp biosynthesis triose- CoA dehydratase: HMPREF9474_RS09785 HMPREF9474_RS19650 HMPREF9474_RS04715 [+ 3 isozymes] [+ 6 isozymes] a (3R)-3- HMPREF9474_RS03800 3'-nucleotidase: HMPREF9474_RS12655 HMPREF9474_RS13960 HMPREF9474_RS20660 HMPREF9474_RS17730 HMPREF9474_RS19745 aminotransferase: HMPREF9474_RS13780 HMPREF9474_RS14750 HMPREF9474_RS21480 HMPREF9474_RS14750 peptidase HMPREF9474_RS01855 γ 3-oxosuccinate HMPREF9474_RS07450 phosphate HMPREF9474_RS04515 α-D-glucosamine [+ 6 isozymes] 1-acyl-sn-glycerol-3- [+ 2 isozymes] HMPREF9474_RS14750 Peptide RS12380 Peptide (S)-3-methyl-2- -L-glutamyl HMPREF9474_RS00770 hydroxyglutaryl- L-homocysteine L-arginino- isomerase: 6-phosphate HMPREF9474_RS19750 phosphate acyltransferase: (S)-2,3,4,5- glycolate butanoate 1,2-dibutyrin 3'-UMP D-galactosamine (S)-NADPHX cytidine [+ 2 isozymes] oxopentanoate 5-phosphate L-homoserine pppGpp crotonyl-CoA N-acetyl-D- a N-acetylmuramoyl- a peptide with butanoyl a carboxylate [acp] methyl ester acetate oxaloacetate 3'-AMP succinate tpiA D-glyceraldehyde HMPREF9474_RS00085 a proteinogenic a D-amino acid tetrahydrodipicolinate a peptide a peptide acetate 6-phosphate (p)ppGpp synthetase: DHAP glucosamine-6- S-ureidoglycolate GDP H + glucosamine pentapeptide- an N-terminal phosphate indole ser branched chain amino gamma- L-serine biosynthesis vitamin B12 dependent homocysteine 3-phosphate phosphate tRNA containing amino acid RS21525 argininosuccinate lyase: Secondary Metabolite Biosynthesis HMPREF9474_RS05665 butanoyl-CoA phosphate deaminase: a 5-carboxymethylaminomethyluridine 34 ser diphosphoundecaprenol L-proline predicted acid aminotransferase: glutamyl- 4-methyl-2- methionine synthase: methyltransferase: guanosine 3'-diphosphate a 7,8-dihydrofolate a thionucleotide HMPREF9474_RS07445 GTP pyrophosphokinase: type I glyceraldehyde-3- dehydrogenase: HMPREF9474_RS22740 ureidoglycolate lyase: in tRNA ABC HMPREF9474_RS22760 phosphate 3-phospho- oxopentanoate HMPREF9474_RS05710 HMPREF9474_RS05705 5'-triphosphate 3'- 1-myristoyl-2-palmitoleoyl Peptide Peptide tryptophan synthase HMPREF9474_RS00590 phosphate dehydrogenase: HMPREF9474_RS17480 glucosamine-6- HMPREF9474_RS00810 transporter reductase: D-glycerate branched chain amino homocysteine vitamin B12 dependent methylerythritol phosphate pathway II diphosphatase: phosphatidate subunit beta: hydroxyacid O-phospho- autoinducer AI-2 biosynthesis I HMPREF9474_RS04950 [+ 2 isozymes] phosphate deaminase: of a peptide ile proA acid aminotransferase: methyltransferase: methionine synthase: arg HMPREF9474_RS15585 HMPREF9474_RS01855 dehydrogenase: L-homoserine D-glyceraldehyde HMPREF9474_RS09925 glyoxylate RS08910 L-glutamate-5- HMPREF9474_RS01700 HMPREF9474_RS22760 HMPREF9474_RS05705 HMPREF9474_RS05710 pyruvate 13-DPG butanoyl-CoA a 2'- (3S)-hydroxy- a (5Z)-3- (S)-3- a (3R,5Z)-3- guanosine predicted tryptophan synthase threonine synthase: 3-phosphate SAM 34 1-palmitoylglycerol a (4Z)-hexadec- a uracil in DNA an L-asparaginyl- ATP 4'-phosphopantetheine a 3-oxoicosanoyl- oleoyl-CoA H O acetyl-CoA H O γ SAICAR 3'-UMP semialdehyde F6P gly a 5,10- a 2-thiouridine arsenate a purine a cis-vaccenoyl-[acp] deoxyribonucleoside a malonyl-[acp] (6Z,9Z,12Z,15Z,18Z,21Z) 2 2 oxododec- hydroxydecanoyl- hydroxy-tetradec- 2',3'-cyclic Glu poly- -D- pro ABC [+ 8 isozymes] GTP ppGpp [DNA] Asn Peptide Peptide subunit beta: 3-phospho- leu met HMPREF9474_RS15850 phosphoglycerate butyryl-CoA:acetate methylenetetrahydrofolate in tRNA ribonucleoside 3-phosphate 5'-triphosphate 4-enoyl-[acp] [tRNA ] [acp] glutamate multifunctional 2',3'- transporter 1-deoxy-D-xylulose-5- -tetracosahexaenoyl-CoA3-hydroxyacyl-CoA 3-oxoacyl-ACP reductase: 5-enoyl-[acp]beta-ketoacyl- CoA 3-hydroxyacyl-CoA 5-enoyl-[acp] monophosphatemultifunctional 2',3'- HMPREF9474_RS16550 hydroxypyruvate kinase: pgk CoA-transferase: beta-hydroxyacyl- cyclic-nucleotide 2'- of a peptide phosphate synthase: dehydrogenase: HMPREF9474_RS17535 ACP reductase: dehydrogenase: cyclic-nucleotide 2'- amino-acid racemase: RS15720 3-phosphoserine/ L-selenocysteine biosynthesis I (bacteria) thr HMPREF9474_RS17405 uracil-DNA glycosylase: pantetheine-phosphate acyl-CoA thioesterase: acetyl-CoA hydrolase: ACP dehydratase: adenylosuccinate lyase: phosphodiesterase/ HMPREF9474_RS10100 SAH 3-phospho- tRNA uridine-5- 1-acyl-sn-glycerol-3- DNA polymerase beta-ketoacyl-[acyl-carrier- HMPREF9474_RS03205 beta-ketoacyl- HMPREF9474_RS03800 HMPREF9474_RS03205 phosphodiesterase/ poly-gamma-glutamate HMPREF9474_RS05530 predicted phosphohydroxythreonine purine-nucleoside HMPREF9474_RS11345 aminoacyl-tRNA hydrolase: adenylyltransferase: coaD HMPREF9474_RS01725 HMPREF9474_RS05245 HMPREF9474_RS03785 HMPREF9474_RS21355 5'-nucleotidase/ trp (S)-1-pyrroline- GTP pyrophosphokinase: D-glycerate butanoate carboxymethylaminomethyl(34) phosphate acyltransferase: III subunit delta: protein] synthase II: 3-hydroxybutyryl- ACP reductase: 3-oxoacyl-ACP reductase: a (2E,5Z)- 5'-nucleotidase/ synthase PgsB: ABC aminotransferase: uracil degradation I (reductive) phosphorylase: uracil-DNA glycosylase: HMPREF9474_RS14095 [+ 2 isozymes] 3-hydroxybutyryl- 3'-nucleotidase: Peptide Peptide ammonia assimilation cycle III 5-carboxylate ser a tRNA sec 1-deoxy-D-xylulose 5'-methylthioadenosine/ HMPREF9474_RS00590 guanosine-3',5'- synthesis: HMPREF9474_RS19650 HMPREF9474_RS04890 HMPREF9474_RS03795 HMPREF9474_RS03800 HMPREF9474_RS17535 tetradeca-2,5- 3'-nucleotidase: HMPREF9474_RS12785 D-proline HMPREF9474_RS13970 Nucleoside and Nucleotide Degradation HMPREF9474_RS07170 HMPREF9474_RS17250 CoA dehydrogenase: a (3R)-3- a (3R,5Z)-3- CoA dehydrogenase: HMPREF9474_RS14750 transporter pyrroline-5- L-glutamate biosynthesis II selenide uracil 5-phosphate S-adenosylhomocysteine bis(diphosphate) HMPREF9474_RS19745 1-acyl-sn-glycerol-3- [+ 10 isozymes] HMPREF9474_RS17475 dienoyl-[acp] HMPREF9474_RS14750 of a peptide 3-oxo- hydroxyicosanoyl- hydroxydodec- HMPREF9474_RS17475 uridine RS10330 carboxylate reductase: 3-phospho- 1-deoxy-D-xylulose- nucleosidase: 3'-diphosphatase: HMPREF9474_RS19750 phosphate acyltransferase: a (6Z)-3- (6Z,9Z,12Z,15Z,18Z,21Z) 3'-dephospho-CoA [acp] oleate acetate 5-enoyl-[acp] 3-oxodecanoyl- 3'-GMP poly-γ-D- AICAR fumarate 2-phospho- superpathway of pyrimidine ribose-1-arsenate Asn ammonium Glu HMPREF9474_RS05145 L-serine serine--tRNA ligase: selenide,water HMPREF9474_RS18575 HMPREF9474_RS15585 HMPREF9474_RS00085 oxooctadec- an apyrimidinic uracil asn tRNA CoA predicted 2-oxoglutarate 5-phosphate GDP D-glycerate deoxyribonucleosides degradation guanosine nucleotides purine ribonucleosides degradation a purine base -tetracosahexaenoyl-CoA glutamate superpathway of L-asparagine biosynthesis glutamate dehydrogenase: HMPREF9474_RS20975 dikinase SelD: reductoisomerase: [DNA] 6-enoyl-[acp] site in DNA ABC L-alanine biosynthesis III pro HMPREF9474_RS02425 5,6-dihydrouracil S-ribosyl-L-homocysteine enolase: degradation III a 5-carboxymethylaminomethyl- a 7,8-dihydrofolate Peptide transporter Peptide HMPREF9474_RS18795 HMPREF9474_RS06895 2'-deoxycytidine 34 type I glutamate- HMPREF9474_RS18175 2-thiouridine in tRNA 1-palmitoyl-2-cis- of a peptide RS02815 glutamate dehydrogenase: an L-seryl- dihydropyrimidinase: ammonia ligase: glnA sec selenophosphate S-ribosylhomocysteine phosphopyruvate adenosine vaccenoyl phosphatidate asp [tRNA ] HMPREF9474_RS18515 MEP cytidine deaminase: GMP cys [+ 3 isozymes] ser HMPREF9474_RS18585 lyase: hydratase: eno Peptide RS18295 Peptide cysteine desulfurase: Glu hydantoinase: HMPREF9474_RS00820 HMPREF9474_RS12700 multifunctional 2',3'- L-glutamate biosynthesis III 2-C-methyl-D- phosphoenol an N 6 -L- a tRNA precursor with 1-cis- a (3R)-3- a (9Z)-3- a (9Z)-3- a (3R,6Z)-3- HMPREF9474_RS02335 L-selenocysteinyl- HMPREF9474_RS03560 cytidine deaminase: thymidine cyclic-nucleotide 2'- (S)-methylmalonyl- (S)-3-hydroxy-(9Z) 2+ CTP a sulfurated 37 a 5-L-glutamyl- 1-palmitoylglycerol a 3-oxohexanoyl- Co precorrin-2 starch AI-2 RS09935 AI-2 L-ornithine degradation asparagine synthetase B: asparagine synthase: erythritol 4-phosphate AI-2 pyruvate phosphodiesterase/ threonylcarbamoyladenine an amino acid pyruvate a 5' extension and a malonyl-[acp] a palmitoleoyl-[acp] a peptide vaccenoylglycerol- hydroxyhexadecanoyl- oxohexadec- -octadecenoyl-CoA oxooctacos- hydroxyoctadec- phe carbonic acid lys cysteine desulfurase NifS: gln tRNA(Sec) synthase: HMPREF9474_RS19015 [sulfur carrier] [peptide] CoA 3-phosphate [acp] nucleotide Peptide RS03980 Peptide I (L-proline biosynthesis) HMPREF9474_RS21510 HMPREF9474_RS16925 2-oxoglutarate 3-ureidopropanoate cytidylyltransferase: pyruvate kinase: 5'-nucleotidase/ in tRNA a short 3' extension 3-phosphate 1-acyl-sn-glycerol-3- [acp] 3-oxoacyl-ACP reductase: 9-enoyl-[acp]3-oxoacyl-ACP reductase: 3-hydroxyacyl-CoA 9-enoyl-[acp]3-oxoacyl-ACP reductase: 6-enoyl-[acp] HMPREF9474_RS14730 HMPREF9474_RS02360 1-acyl-sn-glycerol-3- beta-hydroxyacyl- beta-hydroxyacyl- phenylalanine pyrophosphohydrolase: AI-2 RS19030 AI-2 [+ 2 isozymes] [+ 3 isozymes] glutamate HMPREF9474_RS17835 HMPREF9474_RS05080 2'-deoxyuridine 3'-nucleotidase: phosphate acyltransferase: HMPREF9474_RS17535 HMPREF9474_RS17535 dehydrogenase: HMPREF9474_RS17535 amino-acid racemase: ala glutamate xanthosine adenosine inosine guanosine methylmalonyl-CoA phosphate acyltransferase: ACP dehydratase: sirohydrochlorin ACP dehydratase: ammonia-lyase: alpha-amylase: HMPREF9474_RS22635 L-ornithine an L- synthase (NADPH): 2-C-methyl-D- thymine HMPREF9474_RS14750 gamma-glutamyltransferase: ribonuclease P beta-ketoacyl-[acyl-carrier- HMPREF9474_RS19650 HMPREF9474_RS03205 carbonic anhydrase: HMPREF9474_RS05530 synthase (NADPH): tRNA (N(6)-L- carboxyltransferase: Xaa-Pro aminopeptidase: HMPREF9474_RS19650 HMPREF9474_RS03785 beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- cobaltochelatase: HMPREF9474_RS03785 HMPREF9474_RS03655 HMPREF9474_RS02480 nucleotide Peptide RS05900 Peptide ornithine cyclodeaminase: selenocysteinyl- HMPREF9474_RS04325 erythritol 4-phosphate Cell Structure Biosynthesis pyruvate uracil phosphorylase: guanosine HMPREF9474_RS03095 protein component: protein] synthase II: 3-hydroxybutyryl- HMPREF9474_RS11280 AI-2 RS16965 AI-2 HMPREF9474_RS04325 asn asn (2R,4S)-2-methyl-2,4- threonylcarbamoyladenosine(37) HMPREF9474_RS08540 HMPREF9474_RS08975 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- ACP reductase: ACP reductase: ACP reductase: HMPREF9474_RS05885 a (2E,6Z)- phenylalanine alpha-amylase: pyrophosphohydrolase: HMPREF9474_RS12745 [tRNA sec ] [+ 2 isozymes] cytidylyltransferase: HMPREF9474_RS19020 -C(2))- methylthiotransferase [+ 3 isozymes] HMPREF9474_RS19725 HMPREF9474_RS03795 phosphate acyltransferase: a (2E)-hexadec- HMPREF9474_RS03800 HMPREF9474_RS03800 CoA dehydrogenase: HMPREF9474_RS03800 octadecadienoyl- D-lysine β-alanine dihydroxydihydrofuran-3-one lactate dehydrogenase: purine-nucleoside purine-nucleoside purine-nucleoside purine-nucleoside methylmalonyl-CoA phosphate acyltransferase: a (3R)-3- a (3R,9Z)-3- a cis-delta9-3- ammonia-lyase: HMPREF9474_RS18380 HMPREF9474_RS12460 Glu [+ 3 isozymes] Glu HMPREF9474_RS04815 peptidoglycan biosynthesis I (meso-diaminopimelate containing) purine-nucleoside MtaB: HMPREF9474_RS04705 HMPREF9474_RS00085 2-enoyl-[acp] HMPREF9474_RS17475 [acp] HMPREF9474_RS06335 phosphorylase: phosphorylase: phosphorylase: phosphorylase: carboxyltransferase: 1,2-dicis- HMPREF9474_RS00085 1-palmitoyl-2- hydroxyhexanoyl- hydroxyhexadec- 3-oxo-(9Z)- hydroxyC28:1- HMPREF9474_RS07730 Peptide RS13705 Peptide AI-2 RS09465 AI-2 pro 4-(cytidine 5'- uracil 2-deoxy-α-D- phosphorylase: α CO H O CMP an -(5-L- an (11Z)-3- vaccenoyl- cis-vaccenoyl [acp] 9-enoyl-[acp] [acp] cobalt-precorrin-2 2 2 diphospho)-2-C- UDP-N-acetyl-α-D-glucosamine [+ 2 isozymes] ribose 1-phosphate HMPREF9474_RS07170 HMPREF9474_RS07170 HMPREF9474_RS07170 HMPREF9474_RS07170 HMPREF9474_RS07170 HMPREF9474_RS17010 a tRNA precursor with a proteinogenic a peptide octadecenoyl-CoA trans-cinnamate glucose maltose a 2-methylsulfanyl-N 6 -L- glutamyl)- a peptide a tRNA fragment oxooctadec- phosphatidate phosphatidate methyl-D-erythritol (2R,4S)-2-methyl-2,3,3,4- an unsulfurated a short 3' extension amino acid UDP-N-acetylglucosamine (S)-lactate phosphopentomutase: α threonylcarbamoyladenine 37 5'-deoxyadenosine met amino acid 11-enoyl-[acp] RS03975 4-(cytidine 5'- tetrahydroxytetrahydrofuran guanine -D-ribose- [sulfur carrier] Peptide RS16900 Peptide 1-carboxyvinyltransferase: HMPREF9474_RS19000 1-phosphate in tRNA oxaloacetate propanoyl-CoA diphospho)-2-C-methyl- HMPREF9474_RS02940 D-erythritol kinase: 2-deoxy-D-ribose pyrimidine deoxyribonucleotides phosphopentomutase: HMPREF9474_RS01440 UDP-N-acetylglucosamine 5-phosphate dephosphorylation HMPREF9474_RS19000 Peptide RS15645 Peptide [2Fe-2S] iron-sulfur cluster biosynthesis Cofactor, Carrier, and Vitamin Biosynthesis 2-phospho-4-(cytidine 1-carboxyvinyltransferase: nucleotide N 6 -(3-methylbut- di-trans,octa-cis 1-cis- a (3R)-3- a (7Z)-3- cytidine 2',3'-cyclic an (11Z)-3- a (3R,9Z)-3- flavin biosynthesis I (bacteria and plants) molybdenum cofactor biosynthesis succinate fermentation D-ribose 5- UDP-α-D-glucose RNase III mRNA an N-modified 1-palmitoylglycerol a 3-oxopimeloyl- a cis-delta17-3- 2+ 2+ RS06075 HMPREF9474_RS19515 2-deoxyribose-5- pyrophosphohydrolase: 2-en-1-yl)- -undecaprenyl AICAR a type IV prepilin vaccenoylglycerol- hydroxyhexacosanoyl- oxohexacos- monophosphate oxo-icos-11- hydroxyhexadec- Co sirohydrochlorin Mg protoporphyrin IX methylglyoxal precorrin-6B ala 5'-diphospho)-2-C- to butanoate phosphate a sulfurated [sulfur carrier] processing substrate aminoacyl-[tRNA] 3-phosphate [acp] methyl ester oxo-C36:1-[acp] α phosphate aldolase: xanthine HMPREF9474_RS22635 adenosine 37 in tRNA phosphate 3-phosphate [acp] 7-enoyl-[acp] multifunctional 2',3'- enoyl-[acp] 9-enoyl-[acp] glyoxalase/bleomycin precorrin-6y C5,15- L-cysteine desulfurase methyl-D-erythritol UDP-N-acetyl- -D- 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- 3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: beta-ketoacyl- Peptide RS20450 Peptide 2-C-methyl-D-erythritol glucosamine-enolpyruvate succinate HMPREF9474_RS19005 nucleotide UTP and CTP dephosphorylation I phosphate acyltransferase: beta-hydroxyacyl- HMPREF9474_RS17535 HMPREF9474_RS17535 HMPREF9474_RS17535 cyclic-nucleotide 2'- ACP reductase: beta-hydroxyacyl- resistance/dioxygenase methyltransferase alanine racemase: GTP cys GTP xanthine:NAD+ adenine ribonuclease III: phosphate acyltransferase: ACP dehydratase: phosphodiesterase/ ACP dehydratase: sirohydrochlorin magnesium chelatase HMPREF9474_RS19450 2,4-cyclodiphosphate pyrophosphohydrolase: undecaprenyl- HMPREF9474_RS19650 HMPREF9474_RS03800 family protein: (decarboxylating) cysteine desulfurase: UDP-N- oxidoreductase: tRNA (N6-isopentenyl phosphoribosyltransferase: HMPREF9474_RS05480 aminoacyl-tRNA hydrolase: prepilin peptidase: HMPREF9474_RS19650 HMPREF9474_RS03785 beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- 5'-nucleotidase/ HMPREF9474_RS03785 cobaltochelatase: subunit ChlI: [+ 2 isozymes] RS20040 ATP synthase: D-glyceraldehyde HMPREF9474_RS12460 UTP phosphate glucose HMPREF9474_RS18255 subunit CbiE: HMPREF9474_RS02335 bifunctional 3,4- cysteine desulfurase: cyclic pyranopterin acetylenolpyruvoylglucosamine acetaldehyde HMPREF9474_RS08190 adenosine(37)-C2)- HMPREF9474_RS15605 ribonuclease III: HMPREF9474_RS14095 HMPREF9474_RS17665 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- ACP reductase: ACP reductase: ACP reductase: 3'-nucleotidase: 3-oxoacyl-ACP reductase: a (2E,9Z)- HMPREF9474_RS05885 HMPREF9474_RS09535 Peptide RS19375 Peptide HMPREF9474_RS05490 3-phosphate dCTP dCMP phosphotransferase: a (2E)-hexacos- [+ 3 isozymes] HMPREF9474_RS09365 dihydroxy-2-butanone HMPREF9474_RS02335 phosphate synthase MoaA: reductase: succinyl-CoA methylthiotransferase MiaB: HMPREF9474_RS06945 phosphate acyltransferase: phosphate acyltransferase: a (3R)-3- HMPREF9474_RS03800 a (3R,7Z)-3-HMPREF9474_RS03800 a cis-delta17-3-HMPREF9474_RS03800 HMPREF9474_RS14750 a (3R,11Z)-3-HMPREF9474_RS17535 hexadeca-2,9- D-ala bifunctional urate CTP synthetase: HMPREF9474_RS13825 adenine 2-enoyl-[acp] (R)-lactate precorrin-8x an S-sulfanyl-[L- 4-phosphate synthase/ cysteine desulfurase NifS: HMPREF9474_RS07775 2-C-methyl-D-erythritol- HMPREF9474_RS15125 Glu HMPREF9474_RS20635 1-cis-vaccenoyl-HMPREF9474_RS00085 1-palmitoyl- HMPREF9474_RS00085 hydroxypimeloyl- hydroxyhexacos- hydroxyC36:1- hydroxy-icos- dienoyl-[acp] ala acetaldehyde-CoA/ HMPREF9474_RS00775 phosphoribosyltransferase: an N-terminal 3'-cmp cobalt- Mg- cysteine desulfurase] HMPREF9474_RS14730 (8S)-3',8-cyclo-7,8- 2,4-cyclodiphosphate α deoxyuridine an uncharged 2-palmitoleoyl 2-myristoyl [acp] methyl ester 7-enoyl-[acp] [acp] 11-enoyl-[acp] GTP cyclohydrolase II: an [L-cysteine a carboxy-adenylated UDP-N-acetyl- -D-muramate HMPREF9474_RS11020 RNase III processing an N-modified L-phenylalanyl- a peptide sirohydrochlorin protoporphyrin Peptide RS17515 Peptide RS16890 dihydroguanosine glutamate racemase: alcohol dehydrogenase: 5'-triphosphate UMP 2-methylthio-N 6 - α-D-glucopyranosyl- tRNA HMPREF9474_RS06010 4-hydroxy-3-methylbut-2-en- CTP UMP an mRNA fragment amino acid [type IV prepilin] phosphatidate phosphatidate desulfurase]-S- [small subunit of HMPREF9474_RS11930 nucleotidohydrolase yncF: 5'-deoxyadenosine 37 an unsulfurated product mRNA 5'-triphosphate 1-yl diphosphate synthase: UDP-N-acetylmuramate- HMPREF9474_RS01385 succinate noncanonical pyrimidine dimethylallyladenosine met diphosphoundecaprenol 2,5-diamino-6-(5-phospho-D- sulfanyl-L-cysteine molybdopterin synthase] [+ 2 isozymes] HMPREF9474_RS19270 [sulfur carrier] 5-amino-4- cyclic pyranopterin HMPREF9474_RS06885 -L-alanine ligase: amino-acid racemase: semialdehyde thymine degradation nucleotidase, YjjG family: in tRNA PRPP Peptide RS06580 Peptide an S-sulfanyl-[cysteine ribosylamino)pyrimidin-4(3H)-one monophosphate synthase imidazolecarboxyamide thiamine salvage II (E)-4-hydroxy-3- HMPREF9474_RS22445 HMPREF9474_RS05530 4-hydroxybutyrate acetyl-CoA [+ 2 isozymes] HMPREF9474_RS02690 desulfurase]-[disordered- bifunctional accessory protein: dUTP dUMP RS16785 methylbut-2-en- dehydrogenase: thymine CMP form scaffold diaminohydroxyphosphoribosylaminopyrimidine 4-amino-2-methyl-5- HMPREF9474_RS07770 1-yl diphosphate UDP-N-acetyl-α-D- D-glt multifunctional 2',3'- 4-hydroxy-3- HMPREF9474_RS18735 a 5,10- a 2-thiouridine 34 an α-(γ-L-glutamyl) a (3R)-3- a (7Z)-3-oxo- a (7Z)-3- α-D-glucopyranose a (3R,9Z)-3- an O-acetyl- Mg 2+ RS04435 Mg 2+ protein] complex deaminase/5-amino-6-(5-phosphoribosylamino) a thiocarboxylated cyclic-nucleotide 2'- a [DNA]-3'- + a 5'-phospho- + 1-myristoylglycerol an (S)-2- pyrimidinemethanol cyclic pyranopterin muramoyl-L-alanine multifunctional 2',3'- NAD FAD NADH H a tripeptide hexadec-7- oxotetradec- a cis-delta11-3- NaMN ADP-ribose L-threonine 3- DHAP uracil reductase: HMPREF9474_RS06020 [small subunit of methylbut-2-enyl 4-hydroxybutyrate 5-hydroxy-CTP 5-hydroxy-CMP phosphodiesterase/ methylenetetrahydrofolate in tRNA hydroxyl [DNA] dGTP -L-amino acid 3-phosphate halocarboxylate hydroxytetradecanoyl- phe CTP 1-phosphate hydroxy-octadec- L-ornithine cysteine desulfurase: bifunctional phosphate 5,6-dihydrothymine cyclic-nucleotide 2'- enoyl-[acp] 7-enoyl-[acp] oxo-C30:1-[acp] O-phosphate glycerol-3- molybdopterin synthase] diphosphate reductase: dehydrogenase: 5'-nucleotidase/ 1-acyl-sn-glycerol-3- [acp] beta-ketoacyl- beta-ketoacyl- 3-oxoacyl-ACP reductase: aspartate 9-enoyl-[acp] multifunctional 2',3'- HMPREF9474_RS02335 5-amino-6-(5-phospho- hydroxymethylpyrimidine UDP-N- C1 Compound Utilization phosphodiesterase/ beta-hydroxyacyl- beta-hydroxyacyl- phosphate RS08420 HMPREF9474_RS09310 HMPREF9474_RS04540 dihydropyrimidinase: 3'-nucleotidase: phosphate acyltransferase: ACP reductase: ACP reductase: HMPREF9474_RS17535 cyclic-nucleotide 2'- O-acetyl-ADP- threonine-phosphate amino-acid racemase: Mg 2+ RS14975 Mg 2+ a [cysteine desulfurase]- D-ribosylamino)uracil 4-hydroxy-3- acetylmuramoylalanine- 5'-nucleotidase/ tRNA uridine-5- DNA ligase (NAD(+)) LigA: old Yellow Enzyme gamma- haloacid dehalogenase: ACP dehydratase: aminotransferase: glucose-1-phosphate ACP dehydratase: kinase/ IPP and Assimilation HMPREF9474_RS18515 HMPREF9474_RS14750 peptidase T: HMPREF9474_RS19650 HMPREF9474_RS03800 HMPREF9474_RS03800 beta-ketoacyl- phosphodiesterase/ ribose deacetylase: decarboxylase: HMPREF9474_RS05530 dehydrogenase: S-sulfanyl-[disordered- bifunctional methylbut-2-enyl -D-glutamate ligase: 3'-nucleotidase: carboxymethylaminomethyl(34) HMPREF9474_RS15235 family NADH:flavin glutamylcyclotransferase: HMPREF9474_RS05370 HMPREF9474_RS03785 HMPREF9474_RS06510 cytidylyltransferase: HMPREF9474_RS03785 phosphomethylpyrimidine 4-hydroxybutanoate hydantoinase: deoxyguanosinetriphosphate HMPREF9474_RS09875 1-acyl-sn-glycerol-3- 3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: ACP reductase: a (2E,9Z)- 5'-nucleotidase/ HMPREF9474_RS12420 HMPREF9474_RS09435 gpsA form scaffold diaminohydroxyphosphoribosylaminopyrimidine kinase: diphosphate reductase: HMPREF9474_RS19505 formate assimilation into 5,10- HMPREF9474_RS14750 uridine synthesis: DNA ligase (NAD(+)) LigA: triphosphohydrolase: oxidoreductase: HMPREF9474_RS06310 [+ 8 isozymes] a (2E)-tetradec- [+ 2 isozymes] HMPREF9474_RS01555 (R)-1-amino- sn-glycerol HMPREF9474_RS03560 2-oxo-3- 3'-nucleotidase: 2+ 2+ D-ribulose 5-phosphate HMPREF9474_RS09310 4-hydroxybutyrate methylenetetrahydrofolate HMPREF9474_RS19745 HMPREF9474_RS14310 HMPREF9474_RS21290 phosphate acyltransferase: a (3R,7Z)-3- HMPREF9474_RS17535 a (3R,7Z)-3- HMPREF9474_RS17535 a cis-delta11-3-HMPREF9474_RS03800 octadeca-2,9- 2-propanol O D-ornithine Co RS23170 Co protein] complex deaminase/5-amino-6-(5-phosphoribosylamino) HMPREF9474_RS15410 molybdopterin NAD biosynthesis I (from aspartate) isopentenyl-diphosphate α cytidine HMPREF9474_RS07695 2-enoyl-[acp] phenylpropanoate HMPREF9474_RS14750 3-phosphate RS19100 meso-diaminopimelate UDP-N-acetyl- -D-muramoyl- CoA-transferase: (R)-3-ureido- HMPREF9474_RS19750 1-myristoyl-2- HMPREF9474_RS00085 hydroxy-hexadec- hydroxytetradec- hydroxyC30:1- dienoyl-[acp] β -2-phosphate cysteine desulfurase: bifunctional 3,4- uracil reductase: HMPREF9474_RS06020 Delta-isomerase: a proteinogenic a dipeptide an (R)-2- CDP-α-D-glucose -D- acetate ADP-D-ribose hydroxymethylpyrimidine/ L-alanyl-D-glutamate HMPREF9474_RS04520 formate isobutanoate 5-oxo-L-proline palmitoleoyl a halide anion 7-enoyl-[acp] 7-enoyl-[acp] [acp] HMPREF9474_RS02335 dihydroxy-2-butanone 5-amino-6-(5-phospho- HMPREF9474_RS03765 an L-amino acid amino acid hydroxyacid ribosylnicotinate phosphomethylpyrimidine asp D-ala formate-- AMP [DNA] NMN FADH NAD + phosphatidate K + RS05175 K + 4-phosphate synthase/ D-ribitylamino)uracil UDP-N-acetylmuramyl 4-hydroxybutanoyl- a 5-(aminomethyl)-2- PPP 2 an S-sulfanyl-[cysteine kinase: tetrahydrofolate ligase: a 7,8-dihydrofolate 2'-deoxyguanosine i L-aspartate oxidase: CoA 34 desulfurase]-S- GTP cyclohydrolase II: HMPREF9474_RS16385 molybdopterin DMAPP peptide synthase: D-alanine--D- HMPREF9474_RS17575 thiouridine in tRNA RS13055 sulfanyl-[disordered- HMPREF9474_RS06010 5-(2-hydroxyethyl) adenine dinucleotide HMPREF9474_RS14605 HMPREF9474_RS21045 4-hydroxybutyryl- an N 10 - Carboxylate Degradation alanine ligase A: (R)-3-amino-2- K + RS18785 K + form scaffold -4-methylthiazole HMP-P 2-iminosuccinate CoA dehydratase: formyltetrahydrofolate 1-deoxy-L-glycero- UDP-N-acetyl-α-D-muramoyl- HMPREF9474_RS01390 HMPREF9474_RS04515 methylpropanoate protein] complex ARP hydroxyethylthiazole bifunctional 5,10- L-glutamate degradation V (via hydroxyglutarate) 10 XLLG xyloglucan a (3R)-3- a (5Z)-3- a (3R)-3- an apo-[FeFe] a glucosylated tetrulose 4-phosphate bifunctional quinolinate synthetase: γ acetyl-CoA fermentation to butanoate II an N - a single β 1-palmitoylglycerol a [protein]- a 3-oxodecanoyl- a cis-delta21-3- D-ribose RS08155 D-ribose kinase: L-alanyl- -D-glutamyl- D-alanyl-D-alanine methylene-tetrahydrofolate citrate degradation coproporphyrinogen III SAM AICAR a -D-galactoside oligosaccharide Glu a (6S)-5- an alkylamine hydroxytetracosanoyl- oxotetracos- HAI-1 reduced riboflavin hydroxybutanoyl- hydrogenase glycogenin L-homoserine histidinol cysteine desulfurase: crotonyl-CoA formyltetrahydrofolate stranded DNA L-glutamine + + HMPREF9474_RS16405 hydroxymethylpyrimidine MoO -molybdopterin HMPREF9474_RS14600 meso-2,6-diaminopimelate 3-phosphate [acp] oxo-C40:1-[acp] glycogen- GTP K RS07240 K HMPREF9474_RS02335 2 dehydrogenase/5,10- formyltetrahydrofolate 1-acyl-sn-glycerol-3- [acp] 3-oxoacyl-ACP reductase: 5-enoyl-[acp]3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: N-acyl homoserine old Yellow Enzyme [acp] subunit [FeFe] hydrogenase 6,7-dimethyl-8- kinase/ cofactor Glu acetyl-CoA an acetyl-holo beta-hydroxyacyl- beta-hydroxyacyl- homoserine O- histidinol dehydrogenase: 4-methyl-5(B-hydroxyethyl) quinolinate butanoyl-CoA methylene-tetrahydrofolate phosphate acyltransferase: HMPREF9474_RS17535 HMPREF9474_RS17535 HMPREF9474_RS17535 lactonase family protein: family NADH:flavin H-cluster radical branching enzyme: diguanylate cyclase: chloride RS06925 chloride a [cysteine ribityllumazine phosphomethylpyrimidine UDP-N- citrate [citrate lyase acyl- 5-aminoimidazole-4- exodeoxyribonuclease beta-galactosidase: beta-galactosidase: transglutaminase: ACP dehydratase: ACP dehydratase: succinyltransferase: HMPREF9474_RS15495 -thiazole monophosphate dehydrogenase: cyclohydrolase: coproporphyrinogen HMPREF9474_RS19650 HMPREF9474_RS22480 oxidoreductase: SAM maturase HydG: HMPREF9474_RS18375 HMPREF9474_RS08955 desulfurase]-(S- synthase: ribH kinase: 10 carrier protein] HMPREF9474_RS02900 HMPREF9474_RS02900 beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- biosynthesis protein: N -formyl-tetrahydrofolate biosynthesis nicotinate-nucleotide acetylmuramoylalanyl- HMPREF9474_RS17480 HMPREF9474_RS23415 glutamate III oxidase: carboxamide ribonucleotide VII large subunit: tetrahydrofolate synthase: HMPREF9474_RS18645 HMPREF9474_RS03785 N-(3- HMPREF9474_RS21290 HMPREF9474_RS03785 glycogen- HMPREF9474_RS14325 a drug RS11410 a drug sulfanyl) -[disordered- HMPREF9474_RS15410 phosphate acetyl-CoA beta-galactosidase: beta-galactosidase: 1-acyl-sn-glycerol-3- ACP reductase: ACP reductase: ACP reductase: HMPREF9474_RS12985 [+ 2 isozymes] an anion RS03600 an anion 2 D-glutamyl-2, 6- dehydrogenase: transformylase: HMPREF9474_RS10085 HMPREF9474_RS21225 [+ 2 isozymes] a (2E)-tetracos- a (2E)-but- O-succinyl-L- form scaffold HMPREF9474_RS08125 diphosphorylase Polyprenyl Biosynthesis [+ 2 isozymes] [+ 2 isozymes] acetyltransferase: acetyltransferase: citrate lyase ACP: HMPREF9474_RS06460 phosphate acyltransferase: HMPREF9474_RS03800 HMPREF9474_RS03800 HMPREF9474_RS03800 hydroxybutanoyl) [+ 4 isozymes] [+ 2 isozymes] branching enzyme: his c-di-GMP 6,7-dimethyl-8-(1-D-ribityl)lumazine [+ 2 isozymes] diaminopimelate--D- gdh HMPREF9474_RS07060 exodeoxyribonuclease VII: HMPREF9474_RS03610 HMPREF9474_RS03610 2-enoyl-[acp] a (3R)-3- a (3R,5Z)-3- a cis-delta21-3- 2-enoyl-[acp] an active [FeFe] homoserine protein] complex 4-methyl-5-(2- a tetrahydrofolate (carboxylating): a 5,10- HMPREF9474_RS06990 HMPREF9474_RS03210 HMPREF9474_RS17090 [+ 7 isozymes] HMPREF9474_RS00085 -L-homoserine riboflavin HMPREF9474_RS02820 alanyl-D-alanine ligase: butanoyl-CoA [+ 2 isozymes] HMPREF9474_RS10090 1-palmitoyl-2- 5 hydroxydecanoyl- hydroxytetracos- hydroxyC40:1- hydrogenase a drug RS15335 a drug Cu 2+ RS07330 Cu 2+ phosphooxyethyl) HMP-PP HMPREF9474_RS14610 trans, trans-farnesyl methenyltetrahydrofolate acetyl-CoA [+ 8 isozymes] a (6S)-5- a protein-N - a glycogen riboflavin synthase geranyl diphosphate HMPREF9474_RS21040 a non galactosylated XXXG xyloglucan palmitoleoyl [acp] 5-enoyl-[acp] [acp] subunit thiazole diphosphate biosynthesis di-trans,poly-cis butyryl-CoA:acetate 2-oxoglutarate acetyltransferase: D-galactopyranose D-galactopyranose formyltetrahydrofolate alkylglutamine subunit alpha: vitamin B12 dependent NaMN biosynthesis bifunctional 5,10- acetyl phosphate 5'-deoxyadenosine protoporphyrinogen IX FAICAR a tetrahydrofolate galactose acceptor oligosaccharide phosphatidate -undecaprenyl UDP-N-acetyl-α-D-muramoyl-L- CoA-transferase: HMPREF9474_RS17465 a citryl-holo met a ribonucleoside a single-stranded a [cysteine desulfurase]- HMPREF9474_RS06015 thiamine phosphate dihydrofolate reductase: methionine synthase: methylene-tetrahydrofolate a drug RS07340 a drug RS05160 nicotinate-nicotinamide IPP phosphate biosynthesis alanyl-γ-D-glutamyl-meso-2,6- di-trans,octa-cis- HMPREF9474_RS17405 [citrate lyase acyl- 5'-monophosphate oligodeoxyribonucleotide [scaffold protein- synthase: HMPREF9474_RS04335 HMPREF9474_RS05710 dehydrogenase/5,10- acetate kinase: riboflavin nucleotide isopentenyl-diphosphate (2E,6E)-farnesyl IPP diaminopimeloyl-D-alanyl-D-alanine undecaprenyl phosphate carrier protein] (2Fe-2S)] complex HMPREF9474_RS15405 homocysteine farnesyl-diphosphate methylene-tetrahydrofolate HMPREF9474_RS06985 acetoacetyl-CoA citrate lyase ACP: adenylyltransferase: Delta-isomerase: diphosphatedi-trans,poly-cis- butanoate methyltransferase: synthase: cyclohydrolase: (R)-2- HMPREF9474_RS17090 a drug RS06560 a drug riboflavin kinase: thiamine phosphate HMPREF9474_RS20405 HMPREF9474_RS03765 decaprenylcistransferase: phospho-N-acetylmuramoyl- α-ribazole adenosylcobinamide- a [ThiI sulfur- 4-(γ-L-glutamylamino) XXLG xyloglucan a long-chain a (3R)-3- a (6Z)-3- a guanosine 18 a (3R)-3- a [lipoyl-carrier an N-acyl-L- a [protein]- HMPREF9474_RS05705 HMPREF9474_RS23415 hydroxyglutarate acetate N-acetyl-L- maltotetraose maltohexaose H O a 3-oxooctanoyl- a cis-delta15-3- PAI-1 6 synthase: bifunctional 5,10- HMPREF9474_RS10095 [+ 8 isozymes] 2 oxooctadec- protein]-N -[(R) homoserine HMPREF9474_RS13675 nicotinate adenine DMAPP di-trans,octa-cisHMPREF9474_RS06905 geranyl pentapeptide- transferase: 5'-phosphate GDP Glu cys carrier protein]- butanoate oligosaccharide fatty acyl-CoA hydroxyoctadecanoyl- [acp] oxo-C34:1-[acp] in tRNA hydroxyhexanoyl- repressor LexA L-histidine IMP RS23135 HMPREF9474_RS16400 methylene-tetrahydrofolate bifunctional 5,10- glutaconate CoA- ornithine 6-enoyl-[acp] -dihydrolipoyl]- lactone a [co-chaperone]- dinucleotide -undecaprenyl diphosphate HMPREF9474_RS19500 L-cysteine [acp] 3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: tRNA (Gm18) 2'-O- [acp] N-acyl homoserine histidine kinase: FMN dehydrogenase/5,10- farnesyl-diphosphate NADH repair methylene-tetrahydrofolate transferase: (3R)-3- oxaloacetate beta-hydroxyacyl- beta-hydroxyacyl- L-lysine N-acyl homoserine [scaffold protein- a 7,8-dihydrofolate a 5-methyltetrahydrofolate diphosphate gamma-glutamyl-gamma- beta-galactosidase: glycosyl transferase glycosyl transferase HMPREF9474_RS17535 HMPREF9474_RS17535 HMPREF9474_RS17535 methyltransferase: lactonase family protein: dihydrolipoyl repressor LexA: HMPREF9474_RS04955 inosine monophosphate a drug RS05115 a drug methylene-tetrahydrofolate NAD+ synthetase, synthase: undecaprenyldiphospho- pyruvate fermentation to ethanol I dehydrogenase/5,10- HMPREF9474_RS14695 hydroxybutanoyl- adenosylcobinamide- acyl-CoA thioesterase: ACP dehydratase: ACP dehydratase: lactonase family protein: (2Fe-2S)] complex thiamine NAD(+) synthase: undecaprenyl- aminobutyrate hydrolase: HMPREF9474_RS02900 family 35: family 35: beta-ketoacyl- beta-ketoacyl- beta-ketoacyl- HMPREF9474_RS10225 HMPREF9474_RS22480 dehydrogenase: HMPREF9474_RS20425 [+ 13 isozymes] cyclohydrolase: FMN adenylyltransferase: cyclohydrolase: glutamine dependent: HMPREF9474_RS10095 N-acetylmuramoyl-L-alanyl- methylene-tetrahydrofolate HMPREF9474_RS14700 CoA GDP ribazoletransferase: ornithine acetyltransferase: cysteine desulfurase: HMPREF9474_RS01725 HMPREF9474_RS03785 a 2'-O- HMPREF9474_RS03785 N-(3- HMPREF9474_RS22480 a [protein]- phosphate HMPREF9474_RS10220 diphosphatase: NADH L-malate degradation II HMPREF9474_RS04005 beta-galactosidase: HMPREF9474_RS21555 HMPREF9474_RS21555 ACP reductase: ACP reductase: ACP reductase: HMPREF9474_RS08970 HMPREF9474_RS07065 HMPREF9474_RS13675 HMPREF9474_RS10220 γ (R)-2- HMPREF9474_RS07435 HMPREF9474_RS02335 18 a [lipoyl-carrier RS14540 HMPREF9474_RS23415 geranyl HMPREF9474_RS12335 -D-glutamyl-meso-2,6- pyruvate cyclohydrolase: HMPREF9474_RS09420 a (2E)-octadec- HMPREF9474_RS03800 HMPREF9474_RS03800 HMPREF9474_RS03800 methylguanosine a (2E)-hex- oxododecanoyl) cleaved an N-acyl-L- N-phospho- a drug RS01415 a drug diaminopimeloyl-D-alanyl-D-alanine hydroxyglutaryl- HMPREF9474_RS03610 2-enoyl-[acp] a (3R)-3- a (3R,6Z)-3- a cis-delta15-3- 2-enoyl-[acp] protein]-N 6 -[(R repressor LexA homoserine FAICAR a (6S)-5- NAD + diphosphate HMPREF9474_RS00695 α α in tRNA -L-homoserine L-histidine a [chaperone-ATP]- FAD bifunctional 5,10- undecaprenyl- CoA (S)-malate -D- -D- a long-chain hydroxyoctanoyl- hydroxyoctadec- hydroxyC34:1- )-lipoyl]-L-lysine S-adenosyl-L-methionine cycle I formyltetrahydrofolate UDP-N-acetylglucosamine- a 5,10- a [ThiI sulfur- maltotriose maltopentaose [co-chaperone]- methylene-tetrahydrofolate farnesyl-diphosphate diphosphatase: formate acetyltransferase: 2-hydroxyglutaryl- malate dehydrogenase: adenosylcobalamin N-acetyl-L- 4-aminobutanoate Glu XXXG xyloglucan glucopyranose glucopyranose fatty acid [acp] 6-enoyl-[acp] [acp] phosphopantothenate biosynthesis I crotonyl-CoA L-ornithine ala carrier protein]- D-galactopyranose 2+ 2+ [scaffold protein- thiamine methylenetetrahydrofolate dehydrogenase/5,10-5-formyltetrahydrofolate synthase: HMPREF9474_RS17255 -N-acetylmuramyl- HMPREF9474_RS17750 methylenetetrahydrofolate CoA dehydratase: HMPREF9474_RS08075 5'-phosphate GMP glutamate oligosaccharide 1-phosphate 1-phosphate Fe RS00890 Fe RS03540 diphosphate methylene-tetrahydrofolate di-trans,octa-cis (pentapeptide) S-sulfanyl- (2Fe-2S)] complex reductase [NAD(P)H]: cyclo-ligase: 3-methyl-2- HMPREF9474_RS10095 (R)-NADHX HMPREF9474_RS05090 butanoyl-CoA pyruvate SAM cyclohydrolase:HMPREF9474_RS20650 -undecaprenyl pyrophosphoryl- L-cysteine HMPREF9474_RS05715 oxobutanoate (2E,6E)-farnesyl acetyl-CoA formate bifunctional ADP- [+ 6 isozymes] dehydrogenase: citrate lyase activation HMPREF9474_RS00695 phosphate undecaprenol N- HMPREF9474_RS17480 predicted a 5,10- a 5,10- 3-methyl-2-oxobutanoate diphosphate dependent (S)- (E)-glutaconyl- acetylglucosamine a nascent peptidoglycan with (L- a 2,3,4-saturated XLXG xyloglucan a linear malto- a (3R,5Z)-3- an (11Z)-3- a (3R)-3- 527 4-phospho- ABC methylenetetrahydrofolate methenyltetrahydrofolate bifunctional NAD(P)H-hydrate [+ 2 isozymes] an [HPr]- phosphoenol a [protein] (L-serine/L- a short-chain (2E a guanine long chain a [protein]- 2+ 2+ 3'-dephospho- methionine hydroxymethyltransferase: transferase: CoA 5,6-dimethylbenzimidazole NaMN γ maltopentaose canavaninosuccinate a cis-delta13-3- hydroxy-L- (S)-malate Fe Fe RS03380 a [chaperone- acetaldehyde-CoA/ dehydratase/NAD(P) alanyl- -D-glutamyl-meso-2,6- L-histidine pyruvate 1,2-diacyl-sn- oligosaccharide oligosaccharide threonine) phosphate hydroxy-tetradec- oxooctadec- )-2-enoyl-CoA hydroxypimeloyl- in 16S rRNA polyphosphate asp L-tyrosine transporter an [2Fe-2S] CoA adenosyltransferase: bifunctional 5,10- HMPREF9474_RS00700 HMPREF9474_RS18465 glutaconyl-CoA butanoyl-CoA CTP oxo-C32:1-[acp] 3-hydroxybutyryl- threonine fumarate hydratase: ADP]-[disordered- alcohol dehydrogenase: H-hydrate epimerase: diaminopimeloyl-D-alanine) tetrapeptide glycerol 3-phosphate serine/threonine 5-enoyl-[acp]beta-ketoacyl- 11-enoyl-[acp]3-oxoacyl-ACP reductase: 3-oxoacyl-ACP reductase: [acp] methyl ester 16S rRNA 4-hydroxythreonine- exopolyphosphatase: aspartate tyrosine protein kinase: of Fe2+ cluster protein triphosphoribosyl- HMPREF9474_RS02935 methylene-tetrahydrofolate decarboxylase subunit beta: CoA dehydratase: beta-hydroxyacyl- HMPREF9474_RS19655 form scaffold 2-dehydropantoate lipid II (meso HMPREF9474_RS11930 (S)-NADHX HMPREF9474_RS21480 beta-galactosidase: glycosyl transferase glycosyl transferase phosphatase: ACP reductase: HMPREF9474_RS17535 HMPREF9474_RS17535 methyltransferase G: 4-phosphate HMPREF9474_RS00070 aminotransferase: HMPREF9474_RS08375 dephospho-CoA synthase: dehydrogenase/5,10- HMPREF9474_RS09055 butyryl-CoA:acetate nicotinate-nucleotide-- phosphoenolpyruvate- HMPREF9474_RS17440 ACP dehydratase: predicted protein] complex diaminopimelate containing) [+ 2 isozymes] phosphatidate HMPREF9474_RS02900 family 35: family 35: argininosuccinate lyase: HMPREF9474_RS05330 HMPREF9474_RS03800 beta-ketoacyl- beta-ketoacyl- HMPREF9474_RS19755 dehydrogenase PdxA: exopolyphosphatase: HMPREF9474_RS06510 [+ 2 isozymes] fumarate hydratase: methylene-tetrahydrofolate pyruvate fermentation to acetate IV dimethylbenzimidazole LD-carboxypeptidase: -protein HMPREF9474_RS03785 7 HMPREF9474_RS20955 ATP-dependent NADH- [+ 3 isozymes] CoA-transferase: HMPREF9474_RS07445 [+ 3 isozymes] an N - a [protein]- HMPREF9474_RS19660 2+ ABC 2+ RS04295 met SAH cyclohydrolase: cytidylyltransferase: beta-galactosidase: HMPREF9474_RS21555 HMPREF9474_RS21555 [+ 2 isozymes] 3-oxoacyl-ACP reductase: ACP reductase: ACP reductase: a (2E)- 3-amino-1-HMPREF9474_RS03345 HMPREF9474_RS13665 Fe Fe 2'-(5''-triphospho- HMPREF9474_RS17405 phosphoribosyltransferase: HMPREF9474_RS01960 phosphotransferase: a short-chain (3S)- 527 [+ 2 isozymes] transporter acetaldehyde hydrate dehydratase: HMPREF9474_RS06900 HMPREF9474_RS03800 HMPREF9474_RS03800 methylguanine long chain L-tyrosine fumarate α-D-ribosyl)-3'- HMPREF9474_RS23415 crotonyl-CoA HMPREF9474_RS09410 HMPREF9474_RS06520 HMPREF9474_RS03610 a [protein] Ser/Thr a (5Z)-3-oxo- HMPREF9474_RS17535 a (3R,11Z)-3- a cis-delta13-3- 3-hydroxyacyl-CoA enoylpimeloyl- hydroxyacetone oxaloacetate of Fe2+ biotin biosynthesis from HMPREF9474_RS21480 pyruvate α α in 16S rRNA polyphosphate phosphate dephospho-CoA [+ 2 isozymes] β-alanine alcohol dehydrogenase: butanoate -D- a linear malto- -D- tetradec-5- hydroxyoctadec- hydroxyC32:1- [acp] methyl ester 1-phosphate a [disordered- an [Fe-S cluster homocysteine 5'-methylthioadenosine/ 8-amino-7-oxononanoate I (R)-pantoate a nascent peptidoglycan with maltotetraose L-canavanine fumarate 10 Amine and Polyamine Biosynthesis HMPREF9474_RS03355 NADH an [HPr protein]- a CDP-2,3,4-saturated- XXXG xyloglucan glucopyranose oligosaccharide glucopyranose enoyl-[acp] 11-enoyl-[acp] [acp] a heme RS14545 a heme form [Fe-S] cluster biosynthesis bis(guanylyl molybdenum methyltransferase: S-adenosylhomocysteine an N - butanoyl-CoA 3-hydroxybutyryl- α-ribazole (L-alanyl-γ-D-glutamyl-meso- D-ala D-galactopyranose formate acetyltransferase: nicotinate N π -phospho- pyruvate diacylglycerol oligosaccharide 1-phosphate 1-phosphate RS12230 scaffold protein] chaperone]-ATP cofactor) biosynthesis HMPREF9474_RS05705 nucleosidase: 8-amino-7- formyltetrahydrofolate [+ 6 isozymes] dehydrogenase: CoA dehydratase: 5'-phosphate 2,6-diaminopimelate) tripeptide oxononanoate HMPREF9474_RS17750 L-histidine a holo [citrate MoO -molybdopterin vitamin B12 dependent HMPREF9474_RS18575 adenosylmethionine-8- spermidine biosynthesis I HMPREF9474_RS17480 HMPREF9474_RS17440 molybdopterin 2 putrescine biosynthesis I ethanol a heme RS04130 a heme lyase acyl- cofactor methionine synthase: amino-7-oxononanoate [+ 2 isozymes] [+ 3 isozymes] acetyl-CoA formate carrier protein] HMPREF9474_RS05710L-homocysteine S-ribosyl-L-homocysteine aminotransferase: (R)-pantothenate pyruvate fermentation to acetate I adenosylcobinamide- a guanine 34 1-[18-hydroxyoleyl]- a long-linear (3R,5S)-1-pyrroline-3- a (9Z)-3-oxo- a (1->4)- a (3R)-3- a 1,2-diacyl- a (3R,11Z)-3- a [protein]- a [protein]- 4-amino-2-methyl-5- SAM (S)-3- α-ribazole a proteinogenic leukotriene-C4 queuine glycine betaine a 2-lysophosphatidate α stearoyl-CoA H O a cis-delta19-3- a cytosine in DNA L-tyrosine DNA with lesion RS18420 [citrate (pro-3S) MobA/MobL family protein: HMPREF9474_RS12715 arg GDP in tRNA 2-lyso-phosphatidate -D-glucan 2 hydroxy-5-carboxylate octadec-9- α-D-glucan hydroxyglutaryl- sn-glycerol hydroxyoctadec- thr L-arginine a metal a metal 7,8- tetrahydrofolate salvage from type III pantothenate Glycolysis butanoyl-CoA hydroxybutanoyl- phosphate amino acid oxo-C38:1-[acp] RS05975 diphosphomethylpyrimidine -lyase] ligase: HMPREF9474_RS03715 pyruvate 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- pyrroline-5- enoyl-[acp]beta-ketoacyl- 3-oxoacyl-ACP reductase: DNA (cytosine-5-)- [acp] methyl ester diacylglycerol kinase: 11-enoyl-[acp] ATP--guanido phosphate ABC- cation cation diaminopelargonate 5,10-methenyltetrahydrofolate kinase: arginine decarboxylase: CoA acetyltransferase: beta-hydroxyacyl- beta-hydroxyacyl- serine/threonine protein-tyrosine- biosynthesis HMPREF9474_RS21060 MobA/MobL protein: butyryl-CoA:acetate phosphate acyltransferase: phosphate acyltransferase: glycosyl transferase carboxylate reductase: ACP reductase: HMPREF9474_RS17535 methyltransferase: HMPREF9474_RS10260 phosphotransferase: ATPase HMPREF9474_RS19570 S-adenosylmethionine HMPREF9474_RS18830 3-hydroxyacyl-CoA HMPREF9474_RS06990 adenosylcobinamide- tRNA guanosine(34) glycine/betaine reductase alpha-glucosidase: ACP dehydratase: ACP dehydratase: dehydratase: phosphatase: AIR an acetyl-holo HMPREF9474_RS14865 dethiobiotin synthase: a 5,10- glycolysis I (from glucose 6-phosphate) CoA-transferase: gamma-glutamyltransferase: HMPREF9474_RS00085 HMPREF9474_RS19650 family 35: acyl-CoA thioesterase: HMPREF9474_RS05145 HMPREF9474_RS03800 beta-ketoacyl- HMPREF9474_RS06330 diacylglycerol kinase: HMPREF9474_RS09090 UvrA: uvrA biotin RS04380 biotin decarboxylase: agmatine dehydrogenase: pyruvate:ferredoxin GDP ribazoletransferase: transglycosylase Tgt: C: HMPREF9474_RS02365 HMPREF9474_RS19085 HMPREF9474_RS03785 HMPREF9474_RS03785 HMPREF9474_RS23520 HMPREF9474_RS01710 a metal a metal phosphomethylpyrimidine [citrate lyase acyl- S-ribosylhomocysteine lyase: HMPREF9474_RS12720 methenyltetrahydrofolate (R)-4'- HMPREF9474_RS17405 acetyl phosphate HMPREF9474_RS03095 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- HMPREF9474_RS21555 HMPREF9474_RS01725 ACP reductase: [+ 3 isozymes] HMPREF9474_RS05495 a [protein]- [+ 3 isozymes] RS09685 bifunctional 5,10- HMPREF9474_RS18825 HMPREF9474_RS09420 HMPREF9474_RS13915 trans-4-hydroxy- 3-oxoacyl-ACP reductase: a (2E)- a (2E,11Z)- [+ 2 isozymes] ω a [protein]- carrier protein] HMPREF9474_RS00820 thiamine diphosphate phosphopantothenate D-glucopyranose HMPREF9474_RS03205 oxidoreductase: [+ 2 isozymes] phosphate acyltransferase: phosphate acyltransferase: a 5-methylcytosine N -phospho- DNA without cation cation synthase: bis(molybdenum methylene-tetrahydrofolate agmatinase: [+ 3 isozymes] L-proline a (3R,9Z)-3- HMPREF9474_RS17535 a cis-delta19-3-HMPREF9474_RS03800 enoylglutaryl- a phosphatidate octadeca-2,11- 2-oxobutanoate L-tyrosine biotin RS12725 biotin biosynthesis I (E. coli) dethiobiotin putrescine 6-phosphate butanoate 3-hydroxybutyryl- HMPREF9474_RS09520 HMPREF9474_RS19650 HMPREF9474_RS00085 in DNA L-arginine lesion HMPREF9474_RS12955 cofactor) dehydrogenase/5,10- HMPREF9474_RS18845 acetate kinase: 1-[18-hydroxyoeoyl]-2- α-D- a long-linear hydroxy-octadec- a (1->4)- hydroxyC38:1- [acp] methyl ester dienoyl-[acp] dAdoMet CoA dehydrogenase: a queuosine 34 a 1-acyl-2-palmitoyl-sn α D-glucopyranose HMP-P pyridoxal 5'-phosphate salvage I HMPREF9474_RS06985 α stearate -D-glucan + + MobA/MobL protein: HMP-PP biotin synthase BioB: methylene-tetrahydrofolate SpeB arginase/agmatinase/ phosphosugar isomerase: adenosylcobalamin an α-(γ-L-glutamyl) acetyl phosphate trimethylamine [18-hydroxy-lioleoyl]-sn glucopyranose -D-glucan 9-enoyl-[acp] [acp] Na RS06830 Na HMPREF9474_RS17475 acetyl-CoA CO GMP leukotriene-D4 guanine in tRNA -glycerol 3-phosphate HMPREF9474_RS14865 thiamine phosphate cyclohydrolase: formimionoglutamate 2 -glycerol 3-phosphate 1-phosphate RS03895 bifunctional HMPREF9474_RS12975 HMPREF9474_RS03470 -L-amino acid MobA/MobL family protein: synthase: HMPREF9474_RS23415 spermidine synthase: hydrolase SpeB: acetate hydroxymethylpyrimidine thioredoxin pathway pyridoxine pyridoxamine [+ 2 isozymes] acetoacetyl-CoA phosphate HMPREF9474_RS03715 HMPREF9474_RS15405 biotin [+ 2 isozymes] HMPREF9474_RS18840 HMPREF9474_RS17555 + + kinase/ an N 10 - acetyltransferase: glycolate and Na RS22570 Na bis(guanylyl pyridoxal kinase: pyridoxal kinase: acetyl-CoA phosphomethylpyrimidine an oxidized thiamine phosphate formyltetrahydrofolate putrescine F6P HMPREF9474_RS06990 glyoxylate degradation II a 6-(N-acetyl-α-D-glucosaminyl)- an organic a [protein]- (3S)-hydroxy- a 3- an insertion sequence guanosine 2251 a (3R,7Z)-3- a (3R,5Z)-3- D-gluconate D-sorbitol S-methyl-5'- acetyltransferase: a proteinogenic glutathione H O ATP a glycogen hydantoin a primary alcohol 2-oxoglutarate VAI-1 thiamine RS04915 thiamine molybdopterin cofactor) HMPREF9474_RS23540 HMPREF9474_RS23540 synthase: spermidine 2 asp (6Z,9Z,12Z,15Z,18Z)- oxododecanoyl- hydroxytetradec- hydroxydodec- an L-amino acid D-serine kinase: thioredoxin phosphoribosylglycinamide thioadenosine HMPREF9474_RS03210 1-phosphatidyl-1D-myo-inositol hydroperoxide L-cysteine O-ureidohomoserine element IS30 in 23S rRNA 6-phosphate 6-phosphate HMPREF9474_RS16400 folate polyglutamylation acetyl phosphate amino acid dihydropyrimidinase: NADH-dependent 2+ 2+ HMPREF9474_RS15410 pyridoxine pyridoxamine formyltransferase: fructose-1,6- glycolate tetracosapentaenoyl-CoA3-hydroxyacyl-CoA [acp] 3-oxoacyl-ACP reductase: transposase: 23S rRNA 7-enoyl-[acp] 5-enoyl-[acp] isopropylmalate/ N-acyl homoserine phosphogluconate phosphorylated Ni RS16910 Ni thiamine acetyl-CoA HMPREF9474_RS18515 beta-hydroxyacyl- alcohol dehydrogenase: beta-hydroxyacyl- [+ 2 isozymes] 5'-phosphate 5'-phosphate HMPREF9474_RS23225 bisphosphatase: 2-hydroxy-acid oxidase: dehydrogenase: glycosyl transferase HMPREF9474_RS17535 HMPREF9474_RS14950 (guanosine(2251)-2'-O)- homocitrate/ amino-acid racemase: lactonase family protein: dehydrogenase: carbohydrates D-serine ammonia-lyase: phosphate adenosylcobalamin 6-phosphofructokinase: Secondary Metabolite Degradation acetyltransferase: PIG-L family deacetylase: peroxiredoxin: ATPase AAA: ACP dehydratase: HMPREF9474_RS11090 ACP dehydratase: RS16130 thioredoxin- a tetrahydrofolate HMPREF9474_RS07100 acetate kinase: HMPREF9474_RS19335 gamma-glutamyltransferase: HMPREF9474_RS03205 family 35: beta-ketoacyl- [+ 12 isozymes] methyltransferase RlmB: hydantoinase: citramalate synthase: HMPREF9474_RS05530 HMPREF9474_RS22480 HMPREF9474_RS13395 phosphatase: HMPREF9474_RS23260 HMP-PP salvage from cobalamin a tetrahydrofolate HMPREF9474_RS15150 HMPREF9474_RS17465 HMPREF9474_RS06985 HMPREF9474_RS16690 HMPREF9474_RS09710 HMPREF9474_RS17265 argininosuccinate synthase: an insertion HMPREF9474_RS05475 HMPREF9474_RS03560 HMPREF9474_RS03785 [+ 6 isozymes] HMPREF9474_RS03785 HMPREF9474_RS08430 N-(3- 2-dehydro- HMPREF9474_RS20045 disulfide reductase: pyridoxal pyridoxamine 5'- pyridoxamine 5'- fructose 1,6- glyoxylate HMPREF9474_RS03095 HMPREF9474_RS21555 ACP reductase: 2-O- nitrate RS05360 nitrate N-acetylglucosaminylphosphatidylinositol peroxiredoxin: [+ 23 isozymes] HMPREF9474_RS07450 3-hydroxybutyryl- a trans-∆ 3 -cis-∆ 7 - a (2E,5Z)-dodeca- HMPREF9474_RS06080 phosphate oxidase: [+ 4 isozymes] anhydromuropeptides recycling [+ 3 isozymes] HMPREF9474_RS03800 sequence IS30 with 2251 an aldehyde (2R)-homocitrate oxohexanoyl) 6-phospho- D-sorbitol pyruvate phosphate oxidase: cob(I)alamin tetrahydrofolate synthase: formate-- bisphosphatase: D-sorbitol degradation I acetyl-CoA acetate deacetylase: HMPREF9474_RS01370 HMPREF9474_RS11175 CoA dehydrogenase: a (3R)-3- methylguanosine N-carbamoylglycine a D-amino acid [+ 3 isozymes] HMPREF9474_RS12290 α integrated transposon tetradecenoyl-[acp] 3,5-dienoyl-[acp] -L-homoserine D-gluconate pyridoxal kinase: HMPREF9474_RS12290 thiamine cob(I)yrinic acid a,c-diamide HMPREF9474_RS21225 tetrahydrofolate ligase: HMPREF9474_RS14010 HMPREF9474_RS17475 -D- hydroxydodecanoyl- in 23S rRNA GlcNAc-1,6-anhMurNAc- 3-oxo-(6Z,9Z,12Z,15Z,18Z) maltotetraose RS10500 [+ 2 isozymes] [+ 2 isozymes] diphosphate adenosyltransferase: HMPREF9474_RS17575 ADP H + glucopyranose [acp] nitrate RS08230 nitrate HMPREF9474_RS23540 a 5,10- L-Ala-γ-D-Glu-DAP-D-Ala D-sorbitol α an α-(γ-L-glutamyl) phosphate canavaninosuccinate HMPREF9474_RS21320 fructose 1,6- acetate 6-( -D-glucosaminyl)-1- L-cysteinyl-glycine an alcohol an intra- -tetracosapentaenoyl-CoA 1-phosphate thiamine salvage III a reduced a tetrahydrofolate methylenetetrahydrofolate DHAP Hydrogen Production sorbitol dehydrogenase: (S)-malate phosphatidyl-1D-myo-inositol -L-amino acid protein disulfide an N 10 - bisphosphate cob(I)alamin N-acetylmuramoyl- HMPREF9474_RS20210 acetate thioredoxin PLP formyltetrahydrofolate tetrahydrofolate synthase: fructose-bisphosphate nitrate RS10375 nitrate adenolsyltransferase/ HMPREF9474_RS21225 L-alanine amidase: keto-D-fructose thiamine NAD phosphorylation and dephosphorylation hydrogen production I 1939 RS15305 cobinamide ATP-dependent tetrahydrofolate synthase: triose- aldolase: HMPREF9474_RS06175 RNase R degradation a cytidine 1920 a uracil a ribonucleoside a (3R)-3- thiamine menaquinol-8 biosynthesis methanethiol O-acetyl-L- glutathione NADP + coenzyme A glycochenodeoxycholate a 2-lysophosphatidate maltoheptaose a ribosomal prephenate 2-deoxy-D-ribose PAI-1-2 a D-hexose a double stranded DNA guanylyl molybdenum adenolsyltransferase: HMPREF9474_RS21225 a 5,10- phosphate HMPREF9474_RS01070 [+ 6 isozymes] hypoglycin A substrate RNA an acetoacetyl-[acp] in 23S rRNA in 23S rRNA diphosphate hydroxyicosanoyl- ethylphosphate D-cysteine pyrophosphokinase: a reduced homoserine protein-L-alanine ribokinase: 2+ 2+ NAD + cofactor biosynthesis HMPREF9474_RS04095 methylenetetrahydrofolate isomerase: [+ 4 isozymes] 1-acyl-sn-glycerol-3- 3-oxoacyl-ACP reductase: TlyA family rRNA (cytidine- 23S rRNA (uracil-5-)- ribonucleotide- bifunctional chorismate [acp] alkaline phosphatase N-acyl homoserine DNA gyrase Zn RS07195 Zn an N 10 - ferredoxin [iron- glucokinase: HMPREF9474_RS20985 MoO - demethylmenaquinol-8 adenosylcobalamin tpiA NADH N-acetyl-β-D- γ phosphate acyltransferase: HMPREF9474_RS17535 methyltransferase RumA: diphosphate reductase: ribosomal-protein-alanine mutase/prephenate beta-hydroxyacyl- HMPREF9474_RS00860 lactonase family protein: thiamine 2 L-alanyl- -D-glutamyl-meso- β glycosyl transferase 2'-O)-methyltransferase: family protein: D-cysteine desulfhydrase: subunit B: gyrB formyltetrahydrofolate sulfur] cluster -D-fructofuranose O-acetylhomoserine CoA-disulfide reductase: N-acetyltransferase RimI: ACP dehydratase: HMPREF9474_RS18700 RS10165 diphosphate molybdopterin dimethylmenaquinone glucosamine(anhydrous) 2,6-diaminopimeloyl-D-alanine gamma-glutamyltransferase: choloylglycine hydrolase: ribonuclease R: HMPREF9474_RS00085 family 35: beta-ketoacyl- HMPREF9474_RS10105 HMPREF9474_RS06440 HMPREF9474_RS20805 dehydratase: ribokinase: HMPREF9474_RS03840 HMPREF9474_RS22480 HMPREF9474_RS18655 [+ 2 isozymes] HMPREF9474_RS18210 HMPREF9474_RS17815 HMPREF9474_RS03785 2+ 2+ cofactor MobA/MobL protein: methyltransferase: -N-acetylmuramate fructokinase: aminocarboxypropyltransferase: HMPREF9474_RS03095 HMPREF9474_RS11225 HMPREF9474_RS07925 1-acyl-sn-glycerol-3- HMPREF9474_RS21555 a 2'-O- [+ 2 isozymes] HMPREF9474_RS20810 HMPREF9474_RS00080 HMPREF9474_RS14565 D-hexose 6- Zn RS10305 Zn ATP-NAD kinase: D-glyceraldehyde iron hydrogenase: LD-carboxypeptidase: ACP reductase: 1939 a 2'- a ribosomal [+ 3 isozymes] N-(butyryl)- a negatively acid phosphatase: HMPREF9474_RS12610 Fatty Acid and Lipid Degradation HMPREF9474_RS06870 CoA-disulfide reductase: methylcytidine 1920 a 5-methyluracil 2-oxo-3- a (2E)-icos- 2-deoxy-D-ribose pyruvate HMPREF9474_RS02305 HMPREF9474_RS14865 Fatty Acid and Lipid Biosynthesis 3-phosphate HMPREF9474_RS11355 HMPREF9474_RS01960 HMPREF9474_RS21970 [+ 3 isozymes] phosphate acyltransferase: a (3R)-3- HMPREF9474_RS03800 deoxyribonucleoside protein-N- ethanol L-homoserine phosphate supercoiled DNA HMPREF9474_RS13205 [+ 3 isozymes] HMPREF9474_RS04365 HMPREF9474_RS19650 in 23S rRNA in 23S rRNA phenylpropanoate 2-enoyl-[acp] 5-phosphate NAD(+) kinase: MobA/MobL family protein: α-D- hydroxybutanoyl- 5'-diphosphate acetyl-L-alanine menaquinol-8 L-alanyl-γ-D-glutamyl- fatty acid β-oxidation I a nucleoside 5'- maltohexaose 2+ 2+ [+ 3 isozymes] guanylyl HMPREF9474_RS03715 type I glyceraldehyde-3- F6P acetate chenodeoxycholate a diribonucleotide a phosphatidate glucopyranose Zn RS20080 Zn RS14970 HMPREF9474_RS10110 CDP-diacylglycerol biosynthesis III H 1,6-anhydro-N- meso-diaminopimelate triacylglycerol degradation met gly monophosphate [acp] molybdenum fatty acid elongation -- saturated cardiolipin biosynthesis I fatty acid phosphate dehydrogenase: 2 β hypoglycin B L-cysteinyl-glycine + biotin-carboxyl carrier protein assembly acetyl- -muramate a (3Z)-alk-3- CoA-disulfide NADPH H 1-phosphate cofactor biosynthesis initiation I phosphatidylcholine HMPREF9474_RS04950 enoyl-CoA a triglyceride DHAP sn-glycerol biosynthesis I Zn 2+ RS01655 Zn 2+ NADP + an acyl-[acyl- biotin carboxyl- an acetoacetyl-[acp] a CDP- 3-phosphate acetyl-CoA UDP-N-acetyl-α-D-muramoyl- triacylglycerol lipase: glycerol-3- carrier protein diacylglycerol 13-DPG a [TusE sulfur a [DsrC a 3- 1409 a (3R)-3- (11Z)-(S)-3- a (3R)-3- (S)-1-pyrroline- a (1->4)- RS04895 carrier protein] acetyl-CoA carboxylase HMPREF9474_RS05785 an N-terminal an L-phenylalanyl- 34 1-myristoylglycerol a cytidine α a phosphate choline N-acetyl-β-muramate L-alanyl-γ-D-glutamyl- carrier protein]-S a uridine in tRNA isobutanal [DNA] sulfite a 2-lysophosphatidate oxodocosanoyl- adenosylcobinamide AAI-1 hydroxyhexadec- -D-ribofuranose VAI-1-2 α precorrin-4 phosphate arginyl-[protein] Phe protein]-dithiol in 16S rRNA hydroxydodecanoyl- hydroxydecanoyl- 5-carboxylate -D-glucan bifunctional biotin-- biotin carboxyl carrier choline kinase: meso-2,6-diaminopimelate a 1,2-diglyceride [tRNA ] 3-phosphate ribokinase: monoester alpha-amylase: citrate RS03200 citrate dehydrogenase: acyl phosphate synthase: CDP-diacylglycerol-- 6-phosphate a (2E)-2- -sulfanylcysteine 1-acyl-sn-glycerol-3- 1-acyl-sn-glycerol-3- [acp] 3-oxoacyl-ACP reductase: TlyA family rRNA (cytidine- [acp] N-acyl homoserine 11-enoyl-CoA [acp] 1-pyrroline-5-carboxylate N-acyl homoserine precorrin-4 C(11)- [acetyl-CoA-carboxylase] glycerol-3-phosphate 3- protein subunit: HMPREF9474_RS15870 phosphoglycerate phosphate acyltransferase: cobinamide kinase: beta-hydroxyacyl- enoyl-CoA hydratase: beta-hydroxyacyl- HMPREF9474_RS00860 alkaline phosphatase: HMPREF9474_RS02480 gpsA HMPREF9474_RS06955 enoyl-CoA enoyl-CoA hydratase: phosphate acyltransferase: HMPREF9474_RS17535 2'-O)-methyltransferase: lactonase family protein: dehydrogenase: lactonase family protein: methyltransferase: synthetase/biotin phosphatidyltransferase: HMPREF9474_RS09050 phosphocholine kinase: pgk leucyl/phenylalanyl-tRNA- acetaldehyde anaerobic sulfite reductase: HMPREF9474_RS00085 HMPREF9474_RS09415 ACP dehydratase: HMPREF9474_RS17470 ACP dehydratase: ribokinase: HMPREF9474_RS14260 alpha-amylase: HMPREF9474_RS22015 tRNA 2-thiouridine(34) exodeoxyribonuclease III: HMPREF9474_RS19650 beta-ketoacyl- HMPREF9474_RS10105 HMPREF9474_RS22480 HMPREF9474_RS20655 HMPREF9474_RS22480 cbiF RS06730 sn-glycerol operon repressor: a 3-oxoacyl-[acp] beta-ketoacyl- HMPREF9474_RS20865 [+ 5 isozymes] acyl-CoA dehydrogenase: -protein transferase: dehydrogenase HMPREF9474_RS01210 HMPREF9474_RS03785 [+ 2 isozymes] HMPREF9474_RS03785 HMPREF9474_RS14565 [+ 2 isozymes] HMPREF9474_RS18380 an acyl phosphate synthase MnmA: HMPREF9474_RS02490 1-acyl-sn-glycerol-3- ACP reductase: a 2'-O- adenosyl-cobinamide 3-phosphate HMPREF9474_RS10250 ACP reductase: malonyl-CoA choline-phosphate N-acetyl-D-glucosamine [+ 2 isozymes] (acetylating): HMPREF9474_RS01215 1-acyl-sn-glycerol-3- 1409 N-(3-oxooctanoyl) (2E,11Z)-hexadec- α-D-ribose N-(octanoyl)- a (1->4)- RS14270 3-phospho- fructoselysine and HMPREF9474_RS23570 HMPREF9474_RS15680 HMPREF9474_RS14740 phosphate acyltransferase: methylcytidine a (2E)-dodec- a (2E)-dec- Glu an alcohol precorrin-5 HMPREF9474_RS03800 cytidylyltransferase: 6-phosphate a 2,3,4-saturated a 2-acylglycerol HMPREF9474_RS12580 phosphate acyltransferase: a (3R)-3- HMPREF9474_RS03800 phosphate -L-homoserine 2,11-dienoyl-CoA 5-phosphate L-homoserine α-D-glucan a biotinylated malonyl CoA-acyl carrier D-glycerate psicoselysine degradation acyl-CoA dehydrogenase: a 2,3,4- HMPREF9474_RS19650 in 16S rRNA 2-enoyl-[acp] 2-enoyl-[acp] acyl-phosphate glycerol 3- a phosphatidylglycerophosphate HMPREF9474_RS01905 fatty acid a 2'- HMPREF9474_RS00085 hydroxydocosanoyl- [BCCP monomer] 3-oxoacyl-ACP reductase: protein transacylase: N-acetylglucosamine-6- HMPREF9474_RS17425 saturated (3R)-3- L-phenylalanyl-L- [DNA] dimyristoyl 34 deoxyribonucleoside a [DsrC]-trisulfide a phosphatidate RS13845 phosphate acyltransferase: HMPREF9474_RS17535 2,3-bisphosphoglycerate- phosphate deacetylase: psicoselysine a 2,3,4- hydroxyacyl-CoA a tRNA Phe a 2-thiouridine a [TusE sulfur carrier [acp] HMPREF9474_RS03805 CDP-choline arginyl-[protein] + 5'-monophosphate phosphatidate HMPREF9474_RS20780 independent HMPREF9474_RS12655 a 2,3,4-saturated saturated (3S)-3- in tRNA protein]-L-cysteine isobutanoyl-CoA NADH H fatty acyl CoA a (3R)-3- phosphoglycerate mutase: hydroxyacyl-CoA3-hydroxybutyryl- a 1-monoglyceride RS13025 a 2,3,4-saturated a malonyl-[acp] β hydroxyacyl-[acyl- HMPREF9474_RS04925 D-glucosamine 6-phosphate CoA dehydrogenase: oleate -oxidation a 2-lysophosphatidate a biotinylated fatty acyl-[acp] carrier protein] a phosphatidylglycerol acyl-CoA hydrolysis coenzyme A HMPREF9474_RS17475 an N-terminal an oxidized a 3- (7Z)- a (3R)-3- (2E,7Z)- β-L-galactose type-1 a 2,3,4- (2R,3S)-3- a [protein]-L- D-mannitol RS11270 [BCCP dimer] 3-oxoacyl-ACP synthase: cofactor-independent phosphoglucosamine D-fructosyl- an L-phenylalanyl- NADPH acetyl-CoA (E)-glutaconate NADP + FMNH A ammonium H O a 2-lysophosphatidylcholine nicotinate PRPP adenosylcobinamide α-lactose precorrin-8x (2E,5Z)- ferredoxin [iron- 2 2 oxodocosanoyl- hydroxydocosanoyl- 1-phosphate transmembrane saturated (3S)-3- 1-phosphate 1-acyl-sn-glycerol-3- HMPREF9474_RS08505 a phosphatidylcholine phosphoglycerate mutase: 3-hydroxyacyl-CoA L-lysyl-[protein] [tRNA Phe ] tetradecenoyl-CoA tetradecenoyl-CoA isopropylmalate β-isoaspartate beta-hydroxyacyl- cardiolipin synthase: mutase: L-lysine tetradecenoyl-CoA sulfur] cluster [acp] acyl-CoA dehydrogenase: 3-hydroxyacyl-CoA phosphorylated hydroxyacyl-CoA 3-isopropylmalate phosphorylated beta-galactosidase: phosphate acyltransferase: acetyl-CoA carboxylase 3-oxoacyl-ACP synthase: a 2,3,4-saturated HMPREF9474_RS20965 dehydrogenase: 3-oxoacyl-ACP reductase: [acp] proteins beta-aspartate precorrin-8X acetyl-CoA carboxylase ACP dehydratase: HMPREF9474_RS06860 HMPREF9474_RS17340 glycerol HMPREF9474_RS23570 cobinamide kinase: beta-hydroxyacyl- dehydrogenase: carbohydrates 3-hydroxyacyl-CoA dehydratase: carbohydrates HMPREF9474_RS02900 HMPREF9474_RS00085 carboxyltransferase HMPREF9474_RS03820 fatty acyl CoA fructoselysine 6-kinase: HMPREF9474_RS03205 glutaconate CoA- nicotinate HMPREF9474_RS17535 rhomboid protease GluP: methyltransferase: methylmutase: RS21425 biotin carboxylase subunit: HMPREF9474_RS03785 cardiolipin synthase: acyl-CoA thioesterase: enoyl-CoA hydratase: leucyl/phenylalanyl-tRNA- ferredoxin-NADP+ flavin reductase: hydroxylamine reductase: lysophospholipase: acyl-CoA dehydrogenase: HMPREF9474_RS09415 ACP dehydratase: HMPREF9474_RS03205 phosphatase: dehydrogenase: HMPREF9474_RS18920 phosphatase: beta-galactosidase: 1-acyl-sn-glycerol-3- subunit beta: 2-phospho- D-glucosamine 1-phosphate HMPREF9474_RS03475 a 2,3,4-saturated a 2,3,4-saturated transferase: phosphoribosyltransferase: beta-ketoacyl- HMPREF9474_RS18450 HMPREF9474_RS02400 cbiC RS11005 HMPREF9474_RS03780 HMPREF9474_RS00090 HMPREF9474_RS01725 HMPREF9474_RS22015 -protein transferase: reductase subunit alpha: HMPREF9474_RS23290 HMPREF9474_RS14765 HMPREF9474_RS09530 HMPREF9474_RS17425 HMPREF9474_RS03785 [+ 3 isozymes] HMPREF9474_RS20045 HMPREF9474_RS03205 leuD a protein L-β- HMPREF9474_RS20045 HMPREF9474_RS03610 phosphate acyltransferase: HMPREF9474_RS03775 a trans-2- an acetoacetyl-[acp] a 2,3,4-saturated D-glycerate fructoselysine 6-kinase: fatty acyl CoA 3-oxoacyl-CoA HMPREF9474_RS14695 HMPREF9474_RS21535 ACP reductase: adenosyl-cobinamide cleaved type-1 a 2,3,4-saturated a 2,3,4-saturated [+ 2 isozymes] 3-trans,5-cis- HMPREF9474_RS15680 HMPREF9474_RS04330 [+ 3 isozymes] (2E,7Z)- a (2E)-docos- (S)-3-hydroxy-(7Z) L-galactopyranose (2S)-2- isoaspartate D-mannitol allolactose hydrogenobyrinate HMPREF9474_RS19650 a carboxylated- enoyl-[acyl- Ptd Gro acyl-ACP fatty acid HMPREF9474_RS03570 HMPREF9474_RS14700 a (3R)-3- HMPREF9474_RS03800 phosphate transmembrane 3-oxoacyl-CoA fatty acyl-[acp] 2 enolase: tetradecadienoyl- tetradecenoyl-CoA 2-enoyl-[acp] -tetradecenoyl-CoA isopropylmalate α-methyl ester biotinylated carrier protein] thioesterase pathway fructoselysine hydroxydocosanoyl- proteins HMPREF9474_RS18175 (S)-3- CoA L-phenylalanyl- a reduced sn-glycero-3- a phosphatidate [BCCP dimer] N-acetyl-α-D- 6-phosphate NADP + H + + hydroxylamine a carboxylate NaMN RS01800 an acyl-[acyl- hydroxy-(5Z)- a tRNA Phe ferredoxin [iron- FMN NADPH H phosphocholine [acp] RS21840 phosphopyruvate glucosamine 1-phosphate L-lysyl-[protein] acetate (E)-glutaconyl-CoA phosphatidate carrier protein] hydratase: eno tetradecenoyl-CoA sulfur] cluster cytidylyltransferase: acyl-ACP thioesterase: UDP-N-acetylglucosamine (3E,5Z)- HMPREF9474_RS06900 HMPREF9474_RS14025 phosphoenol pyrophosphorylase: acetyl-CoA a fatty acid pyruvate HMPREF9474_RS07110 β-D-glucose tetradecadienoate cob(I)yrinate N-acetyl-D-glucosaminyl-N- a dietary all- (5Z)- UDP-N-acetyl- α-D-glucopyranose a (3R,7Z)-3- D-glucopyranose cytidine a CDP- ATP NAD + FMNH ammonium NAD + H O a glycogen acetyl phosphate uroporphyrinogen-I α-D-glucosamine an acyl phosphate ribulose DHAP L-tartrate precorrin-2 RS21250 RS10570 UDP-N-acetyl- 6-phosphate lys asp a,c-diamide acetylmuramoyl-L-alanyl-D-glutamyl- 2 2 trans-retinyl ester tetradecenoyl-CoA 1-phosphate hydroxy-hexadec- 6-phosphate diacylglycerol CAIR UDP-N-acetyl- ribulokinase: cytidine deaminase: pyruvate kinase: α-D-glucosamine 6-carboxy-L-lysyl-D-alanine acyl-CoA dehydrogenase: uroporphyrinogen phosphorylated 7-enoyl-[acp] phosphorylated methylglyoxal synthase: precorrin-2 C(20)- glycine/betaine reductase D-glucosamine beta-hydroxyacyl- HMPREF9474_RS09930 tartrate dehydrogenase: HMPREF9474_RS12700 Nucleoside and Nucleotide Biosynthesis HMPREF9474_RS05080 glycosyl transferase HMPREF9474_RS23570 decarboxylase: carbohydrates acylphosphatase: carbohydrates HMPREF9474_RS20560 methyltransferase: cob(I)yrinic acid a,c-diamide flavin reductase: C: HMPREF9474_RS02365 dehydrogenase: ACP dehydratase: HMPREF9474_RS06470 cytidine deaminase: Aromatic Compound nitrite reductase: family 35: triacylglycerol lipase: acyl-CoA dehydrogenase: HMPREF9474_RS03015 phosphatase: HMPREF9474_RS16960 phosphatase: ribulokinase: methylglyoxal synthase: HMPREF9474_RS05955 phosphoribosylaminoimidazolesuccinocarboxamide adenosyltransferase: LD-carboxypeptidase: HMPREF9474_RS23290 [+ 3 isozymes] HMPREF9474_RS16705 HMPREF9474_RS03785 HMPREF9474_RS13540 HMPREF9474_RS19015 UMP biosynthesis III Carbohydrate Degradation Degradation HMPREF9474_RS18750 HMPREF9474_RS21555 HMPREF9474_RS05785 HMPREF9474_RS17425 HMPREF9474_RS20045 a (2E,7Z)- HMPREF9474_RS20045 HMPREF9474_RS01815 2-hydroxy-3- RS02555 superpathway of guanosine nucleotides de novo biosynthesis II superpathway of adenosine nucleotides de novo biosynthesis II pyrimidine deoxyribonucleotides de novo biosynthesis II 5-aminoimidazole synthase: HMPREF9474_RS21350 HMPREF9474_RS21320 HMPREF9474_RS01960 [+ 3 isozymes] (2E,5Z)- coproporphyrinogen I UDP-N-acetyl-α-D- a carboxylate L(or D)-ribulose precorrin-3A uridine pyruvate gly D-glucopyranose hexadeca-2,7- D-glucopyranose methylglyoxal oxosuccinate RS13750 ribonucleotide biosynthesis I gallate degradation tetradecenoyl-CoA glucosaminouronate 5-phosphate superpathway of glucose and xylose degradation α-D-glucopyranose dienoyl-[acp] gln Macromolecule Modification L-arabinose degradation I D-mannose degradation III (anaerobic) adenosyl- N-acetyl-D-glucosaminyl-N- an α-limit dextrin a long-chain hydrogencarbonate formate PPP + nitrite all-trans-retinol IMP IMP PRPP cobyrinate i FMN NADH H 1-phosphate fatty acid asp UTP CTP D-glucopyranose SAICAR acetylmuramoyl-L-alanyl-D- D-ala RS10230 amidophosphoribosyltransferase: a,c-diamide queuosine biosynthesis 6-phosphate L-arabinopyranose D-mannopyranose gallate glutamyl-6-carboxy-L-lysine inosine 5-monophosphate HMPREF9474_RS05235 carbamoyl phosphate anaerobic ribonucleoside- anaerobic ribonucleoside- L-arabinose isomerase: 6-phosphate RS11165 dehydrogenase: amidophosphoribosyltransferase: glucose-6-phosphate mannose-6- synthase large subunit: adenylosuccinate triphosphate reductase: triphosphate reductase: HMPREF9474_RS22910 preQ dehydrogenase: phosphate isomerase: N-acetyl-β- 1915 a (3R)-3- HMPREF9474_RS00780 HMPREF9474_RS05215 synthetase: HMPREF9474_RS23830 HMPREF9474_RS23830 β HMPREF9474_RS09610 0 an acetylated acetyl 1-18:1-2- a pseudouridine (7Z)- (5Z)- dCDP 5-phospho- - HMPREF9474_RS12445 L-ribulose HMPREF9474_RS00985 pyrogallol alginate pyruvate an unsulfurated a 3-oxohexacosanoyl- cis-vaccenoyl-CoA porphobilinogen a sugar phosphate indole-3-acetamide starch [DNA] L-cysteate propionamide precorrin-3B [+ 2 isozymes] IMP dehydrogenase: HMPREF9474_RS21365 acceptor donor cys lysophosphatidylethanolamine neuraminate in 23S rRNA hexadecenoyl-CoA dodecenoyl-CoA hydroxyoctanoyl- ribonucleotide- RS17695 [+ 2 isozymes] [+ 2 isozymes] D-ribosylamine 6-phospho F6P [sulfur carrier] 23S rRNA [acp] acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: phosphorylated alpha-amylase: aspartate HMPREF9474_RS09960 ribulokinase: 3-oxoacyl-ACP reductase: hydroxymethylbilane amidase: [acp] amidase: precorrin-3B C(17)- diphosphate reductase: phosphoribosylamine- D-glucono- (pseudouridine(1915)-N(3) HMPREF9474_RS23570 HMPREF9474_RS23570 HMPREF9474_RS23570 carbohydrates beta-hydroxyacyl- HMPREF9474_RS02480 DNA polymerase IV: aminotransferase: dCTP preQ HMPREF9474_RS13540 HMPREF9474_RS17535 synthase: HMPREF9474_RS05535 HMPREF9474_RS05535 methyltransferase: HMPREF9474_RS20805 carbamoyl asp adenylo-succinate -glycine ligase: 1 1,5-lactone alginate O- pyruvate, lysophospholipase: N-acetylneuraminate lyase: )-methyltransferase RlmH: phosphatase: ACP dehydratase: alpha-amylase: HMPREF9474_RS11060 HMPREF9474_RS06510 RS16590 XMP ribulokinase: beta-ketoacyl- acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: HMPREF9474_RS09485 acyl-CoA dehydrogenase: [+ 2 isozymes] [+ 2 isozymes] HMPREF9474_RS09360 HMPREF9474_RS20810 phosphate HMPREF9474_RS23230 tRNA guanosine(34) acetyltransferase AlgJ: phosphate dikinase: cysteine desulfurase: HMPREF9474_RS09530 HMPREF9474_RS15515 HMPREF9474_RS23455 HMPREF9474_RS20045 HMPREF9474_RS03785 HMPREF9474_RS18380 dCTP deaminase: 6-phosphogluconolactonase: phloroglucinol an N 3 - ACP reductase: HMPREF9474_RS17425 HMPREF9474_RS17425 HMPREF9474_RS17425 a nucleoside 5'- [+ 2 isozymes] adenylosuccinate lyase: HMPREF9474_RS09930 HMPREF9474_RS20330 HMPREF9474_RS04630 HMPREF9474_RS02335 (2E,7Z)- (2E,11Z)- preuroporphyrinogen (2E,5Z)- indole-3-acetate a large- propanoate precorrin-4 CDP RS14795 HMPREF9474_RS20435 transglycosylase Tgt: HMPREF9474_RS12455 1915 a sugar a (2E)-oct- 3-sulfopyruvate aspartate GMP synthase: HMPREF9474_RS21355 GAR methylpseudouridine a (3R)-3- HMPREF9474_RS03800 hexadecenoyl-CoA octadecenoyl-CoA dodecenoyl-CoA branched glucan monophosphate HMPREF9474_RS13915 6-phosphogluconolactonase: L-ribulose 5-phosphate N-acetyl-β-D- in 23S rRNA 2-enoyl-[acp] carbamoyltransferase: HMPREF9474_RS16475 dUTP a 7-aminomethyl-7- phosphoenol sn-glycero-3- pyruvate hydroxyhexacosanoyl- phosphoribosylglycinamide HMPREF9474_RS12490 acetylated alginate a non-acetylated + oleate mannosamine a sugar RS03315 a sugar HMPREF9474_RS07650 [+ 2 isozymes] AMP deazaguanosine 34 L-ribulose-5-phosphate AMP diphosphate H phosphoethanolamine [acp] formyltransferase: D-gluconate acetyl acceptor donor pyruvate ala a sulfurated [sulfur carrier] HMPREF9474_RS07655 deoxyuridine in tRNA 4-epimerase: araD RS23545 HMPREF9474_RS23225 6-phosphate dihydrophloroglucinol GMP adenylate kinase: 5'-triphosphate tRNA preQ1(34) S- L-ribulose-5-phosphate HMPREF9474_RS02190 nucleotidohydrolase yncF: phosphogluconate a sugar RS01125 a sugar N-carbamoyl- FGAR adenosylmethionine 4-epimerase: araD HMPREF9474_RS19270 dehydrogenase: 6 1518 1402 ribosyltransferase- + a [histone]-N - a DNA containing an adenine / a [release factor]- (2E,7Z)- a monocarboxylic a cytidine (R)-10- an organic cobalt- UDP L-aspartate guanylate kinase: ADP NAD glycyl-glycine glutathione diphosphate H O maltohexaose a 3-oxohexadecanoyl- palmitoleoyl-CoA oleoyl-CoA 4-hydroxybenzoate wound RNA a nitrile [+ 2 isozymes] phosphoribosylformylglycinamidine HMPREF9474_RS13395 D-xylulose 5-phosphate acetyl-L-lysine 2 apurinic/apyrimidinic site adenine 1519 in 16S rRNA L-glutamine hexadecenoyl-CoA acid amide in 16S rRNA Hydroxystearate hydroperoxide precorrin-5B HMPREF9474_RS18345 isomerase QueA: [acp] ribonucleotide- a sugar RS08170 a sugar RS06545 [+ 2 isozymes] 3-hydroxy-5- 16S rRNA (adenine(1518) acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: peroxiredoxin: 1 dihydroorotase: dUMP synthase: HMPREF9474_RS09170 HMPREF9474_RS14290 3-oxoacyl-ACP reductase: phenolic acid protein-(glutamine-N5) enoyl-CoA hydratase: acetamidase: rRNA (cytidine-2'-O- nitrilase: cobalt-precorrin-5B (C diphosphate reductase: guanylate kinase: oxohexanoate -N(6)/adenine(1519)-N(6) HMPREF9474_RS23570 HMPREF9474_RS23570 RNA helicase: oleate hydratase: HMPREF9474_RS09710 HMPREF9474_RS02695 34 D-ribulose NAD-dependent HMPREF9474_RS17535 decarboxylase subunit B: methyltransferase: HMPREF9474_RS22015 HMPREF9474_RS19040 )-methyltransferase: HMPREF9474_RS09205 )-methyltransferase: HMPREF9474_RS20805 HMPREF9474_RS20880 FGAM adenine salvage an epoxyqueuosine butyryl-CoA:acetate gamma-glutamyltransferase: inorganic endonuclease III: alpha-glucosidase: )- dimethyltransferase: acyl-CoA dehydrogenase: acyl-CoA dehydrogenase: HMPREF9474_RS02880 HMPREF9474_RS21415 peroxiredoxin: in tRNA 5-phosphate protein deacylase: HMPREF9474_RS03095 HMPREF9474_RS19085 beta-ketoacyl- HMPREF9474_RS11510 HMPREF9474_RS17285 [+ 2 isozymes] [+ 3 isozymes] HMPREF9474_RS18365 [+ 5 isozymes] HMPREF9474_RS09345 HMPREF9474_RS20810 CoA-transferase: pyrophosphatase: HMPREF9474_RS12690 HMPREF9474_RS03675 HMPREF9474_RS17425 HMPREF9474_RS17425 5 a 2'-O- HMPREF9474_RS11175 a sugar RS15535 a sugar (S)-dihydroorotate GDP ribonucleotide- ribonucleotide- ATP synthase F1 HMPREF9474_RS13050 N 6 -dimethyladenine 1518 ACP reductase: a [release factor]-N (S)-3-hydroxy-(7Z) cobalt- superpathway of pyrimidine phosphoribosylformylglycinamidine [+ 3 isozymes] HMPREF9474_RS18715 (2E,9Z)- (2E,9Z)- phenol a monocarboxylate 1402 an unwound RNA oleate a carboxylate dUDP subunit epsilon: dTMP ribulose-phosphate ribose 5-phosphate HMPREF9474_RS17405 6 1519 methylcytidine an alcohol RS06935 diphosphate reductase: diphosphate reductase: nucleobases salvage /N -dimethyladenine a (3R)-3- HMPREF9474_RS03800 hexadecenoyl-CoA octadecenoyl-CoA -methyl-L-glutamine -hexadecenoyl-CoA precorrin-6A dihydroorotate HMPREF9474_RS01140 cyclo-ligase: HMPREF9474_RS23220 adenine 3-epimerase: isomerase B: 3-hydroxy-5- in 16S rRNA HMPREF9474_RS20805 HMPREF9474_RS20805 D-galactose degradation I (Leloir pathway) 3''-O-acetyl- a 3'-terminal D-glucopyranose maltopentaose in 16S rRNA hydroxyhexadecanoyl- ribonucleotide- ribonucleotide- 34 γ a sugar RS10990 a sugar dehydrogenase B HMPREF9474_RS20810 HMPREF9474_RS20810 [+ 17 isozymes] uracil a queuosine HMPREF9474_RS20990 HMPREF9474_RS11490 oxohexanoyl-CoA a [histone]-L-lysine nicotinamide -L-glutamyl- a 5'-phospho-[DNA] diphosphate reductase: diphosphate reductase: AIR D-xylopyranose ADP-ribose L-cysteinyl-glycine H + unsaturated sugar [acp] catalytic subunit: uracil in tRNA glycylglycine phosphate HMPREF9474_RS20805 HMPREF9474_RS20805 β HMPREF9474_RS05630 dTDP phosphoribosyltransferase: adenine adenine deaminase: D-xylulose D-ribose 5- -D-galactose RS19910 HMPREF9474_RS20810 HMPREF9474_RS20810 a sugar RS19215 a sugar [+ 2 isozymes] GTP HMPREF9474_RS07085 phosphoribosyltransferase: HMPREF9474_RS07135 5-phosphate phosphate UMP galactose mutarotase: (S)-3- PRPP HMPREF9474_RS15605 a [protein]-N 6 - an oxidized a (7Z,10Z,13Z,16Z a [2-oxoglutarate 2-deoxy-5-dehydro- a single dCDP orotate ATP HMPREF9474_RS07125 hydroxybutanoyl-CoA + maltotriose a 3-oxotetradecanoyl- (2E,9Z)- (2E,9Z)- dihydroxyacetone 3-(7'-methylthio) 6 37 D-xylulose NAD ATP cobinamide dehydrogenase E2 protein] a [protein] Ser/Thr uroporphyrinogen-III 3-phenylpropionitrile spermidine cobyrinate propan-1-ol dADP dTTP cytidylate kinase: guanine and adenine N -L-threonylcarbamoyladenosine transketolase: acetyl-L-lysine ammonium ferredoxin [iron- H O ,19Z)-3-oxodocosa- D-gluconate hexadecenoyl-CoA octadecenoyl-CoA heptylmalate stranded DNA dGDP α 3-hydroxybutyryl- 2 6 [acp] 5-dehydro-2- dihydroxyacetone ribonucleotide- predicted anaerobic ribonucleoside- HMPREF9474_RS06465 guanosine salvage phosphoribosyltransferase: hypoxanthine -modified tRNA biosynthesis HMPREF9474_RS18695 -D-galactose sulfur] cluster 7,10,13,16,19-pentaenoyl-[acp]3-oxoacyl-ACP reductase: N -dihydrolipoyl-L-lysine 3-oxoacyl-ACP reductase: HPr kinase: uroporphyrinogen-III nitrilase: enoyl-CoA hydratase: enoyl-CoA hydratase: spermine/spermidine 3-isopropylmalate DNA primase: cobyrinic acid a,c- alcohol dehydrogenase: RS01080 orotate adenine and anaerobic ribonucleoside- xylulokinase: CoA dehydratase: dihydrolipoyl deoxygluconokinase: kinase subunit L: diphosphate reductase: ABC triphosphate reductase: [+ 5 isozymes] HMPREF9474_RS11020 [+ 7 isozymes] HMPREF9474_RS17535 HMPREF9474_RS17535 HMPREF9474_RS15140 C-methyltransferase: HMPREF9474_RS14155 HMPREF9474_RS22015 HMPREF9474_RS17470 acetyltransferase: dehydrogenase: HMPREF9474_RS07690 diamide synthase: HMPREF9474_RS03355 a sugar a sugar phosphoribosyltransferase: adenosine salvage I triphosphate reductase: HMPREF9474_RS05845 HMPREF9474_RS17440 NAD-dependent cob(I)yrinic acid a,c-diamide alpha-glucosidase: dehydrogenase: HMPREF9474_RS13035 HMPREF9474_RS14255 HMPREF9474_RS20805 transporter HMPREF9474_RS23830 xanthine thr galactokinase: ferredoxin-- beta-ketoacyl- beta-ketoacyl- [+ 3 isozymes] HMPREF9474_RS09490 [+ 5 isozymes] [+ 2 isozymes] [+ 2 isozymes] HMPREF9474_RS05795 HMPREF9474_RS13955 DNA primase: HMPREF9474_RS09370 [+ 6 isozymes] HMPREF9474_RS05625 HMPREF9474_RS23830 UDP guanosine [+ 2 isozymes] D-sedoheptulose D-glyceraldehyde protein deacylase: adenosyltransferase: HMPREF9474_RS19085 HMPREF9474_RS08970 HMPREF9474_RS20810 of a sugar [+ 2 isozymes] HMPREF9474_RS13290 [+ 3 isozymes] nitrite reductase: [+ 2 isozymes] [+ 4 isozymes] 8 HMPREF9474_RS10625 purine-nucleoside phosphoribosyltransferase: threonylcarbamoyl- D-xylulose HMPREF9474_RS13050 HMPREF9474_RS21320 ACP reductase: a [2-oxoglutarate ACP reductase: 5-dehydro-2-deoxy-D- a [protein] (L-serine/L- (S)-3-hydroxy-(9Z) (S)-3-hydroxy-(9Z) N - 10-(methylthio)- a short RNA cob(II)yrinate CDP adenosine AMP 7-phosphate 3-phosphate HMPREF9474_RS18945 precorrin-2 3-phenylpropanoate 1-propanal orotidine 5'- phosphorylase: HMPREF9474_RS00565 AMP synthase: 5-phosphate α-D-galactose crotonyl-CoA a (3R,7Z,10Z,13ZHMPREF9474_RS03800,16Z dehydrogenase E2 a (3R)-3- HMPREF9474_RS03800 gluconate 6-phosphate threonine) phosphate -hexadecenoyl-CoA -octadecenoyl-CoA DHAP acetylspermidine 2-oxodecanoate segment a,c-diamide predicted xanthine and α 6 RS10135 purine-nucleoside hypoxanthine HMPREF9474_RS12705 UDP- -D-glucose protein] N -lipoyl-L-lysine ABC phosphate xanthosine salvage dATP HMPREF9474_RS07170 1-phosphate 3''-O-acetyl- ,19Z)-3-hydroxydocosa- D-glucopyranose maltose hydroxytetradecanoyl- a sugar a sugar dGTP phosphorylase: UTP phosphoribosyltransferase: L-threonylcarbamoyladenylate transaldolase: butanoyl-CoA nicotinamide a [protein]-L-lysine adenosylcobinamide PPP transporter guanine ADP-ribose i 7,10,13,16,19-pentaenoyl-[acp] [acp] orotidine 5'-phosphate HMPREF9474_RS07170 CTP synthetase: HMPREF9474_RS22675 HMPREF9474_RS19070 dehydrogenase: nitrite of a sugar adenine tRNA (adenosine(37)-N6)- decarboxylase: HMPREF9474_RS00775 HMPREF9474_RS17480 xanthosine pyrimidine deoxyribonucleotide xanthine threonylcarbamoyltransferase D-erythrose a sugar RS03850 a sugar RS12930 HMPREF9474_RS05640 IMP F6P [+ 2 isozymes] purine-nucleoside phosphorylation CTP phosphoribosyltransferase: complex: 4-phosphate an [amino-group carrier protein]- (S)-3- a 2,3,4- adenine 3-methyl-2- 5,10-methylene- a 2,3,4-saturated (2E,6Z,9Z,12Z,15Z,18Z,21Z) adenosyl-cobyrinate (2E,11Z)- 3-(4'-methylthio) an adenosine 34 UDP UMP phosphorylase: HMPREF9474_RS00565 HMPREF9474_RS17805 butanoyl-CoA H + hydrogencarbonate acetate γ maltopentaose a 3-oxotetracosanoyl- 3-hydroxyisovaleryl-CoA an mRNA 2-deoxygluconate spermidine pyruvate D-glycerate phosphoribosyltransferase: dTMP dCMP transketolase: oxobutanoate tetrahydromethanopterin fatty acyl CoA C-terminal- -(L-glutamate 5- hydroxyhexadecanoyl- saturated (3R)-3- Arg2 CMP phosphorylation HMPREF9474_RS07170 hypoxanthine -tetracosaheptaenoyl-CoA [acp] a,c-diamide octadecenoyl-CoA butylmalate in [tRNA ] ribonucleotide- HMPREF9474_RS15605 cytidylate kinase: HMPREF9474_RS17810 HMPREF9474_RS18695 semialdehyde-2-yl)-L-glutamate 3-oxoacyl-ACP reductase: CoA hydroxyacyl-CoA a sugar RS03480 a sugar xanthine phosphoribosyltransferase: butyryl-CoA:acetate N-acetyl-gamma-glutamyl- enoyl-CoA hydratase: enoyl-CoA hydratase: enoyl-CoA hydratase: cobyric acid enoyl-CoA hydratase: 2-deoxy-D-gluconate enoyl-CoA hydratase: spermine/spermidine 3-isopropylmalate tRNA-specific diphosphate reductase: HMPREF9474_RS06465 HMPREF9474_RS17830 [+ 7 isozymes] HMPREF9474_RS17535 mRNA interferase PemK: pyruvate kinase: glycerate kinase: RS01880 CMP adenine 6 CoA-transferase: 3-methyl-2-oxobutanoate butyryl-CoA:acetate HMPREF9474_RS17470 HMPREF9474_RS22015 synthase CobQ: HMPREF9474_RS22015 3-dehydrogenase: acetyltransferase: dehydrogenase: adenosine deaminase: HMPREF9474_RS20805 xanthine dTDP HMPREF9474_RS22675 an N -L- fucose degradation carbonic anhydrase: phosphate reductase: alpha-glucosidase: HMPREF9474_RS22015 HMPREF9474_RS21490 HMPREF9474_RS22015 HMPREF9474_RS05080 HMPREF9474_RS20250 phosphoribosyltransferase: [+ 4 isozymes] 37 D-glyceraldehyde hydroxymethyltransferase: [+ 2 isozymes] beta-ketoacyl- [+ 2 isozymes] HMPREF9474_RS09445 [+ 2 isozymes] HMPREF9474_RS22615 HMPREF9474_RS05795 HMPREF9474_RS13955 HMPREF9474_RS22755 cytidylate kinase: phosphoribosyltransferase: threonylcarbamoyladenine HMPREF9474_RS17405 CoA-transferase: HMPREF9474_RS07440 HMPREF9474_RS19085 [+ 2 isozymes] [+ 2 isozymes] HMPREF9474_RS20810 a sugar RS09945 a sugar dCDP HMPREF9474_RS00700 HMPREF9474_RS11280 an [amino-group carrier protein]- (3S)-hydroxy- ACP reductase: (E)-2- (S)-3-hydroxy-(11Z) 3-dehydro-2- N 1 - 7-(methylthio)-2- an inosine 34 phosphoenol 2-phospho- HMPREF9474_RS06465 HMPREF9474_RS11020 GMP in tRNA 3-phosphate HMPREF9474_RS17405 trans-hexadec- an mRNA fragment adenosylcobyrate dUDP HMPREF9474_RS00565 β-L-fucopyranose acetyl-CoA γ (6Z,9Z,12Z,15Z,18Z,21Z) a cis-2-enoyl-CoA Arg2 [+ 4 isozymes] type I glyceraldehyde-3- C-terminal- -(5-phospho- a (3R)-3- HMPREF9474_RS03800 methylcrotonoyl-CoA 2-enoyl-CoA -octadecenoyl-CoA deoxy-D-gluconate acetylspermidine oxoheptanoate in [tRNA ] pyruvate D-glycerate AMP -tetracosahexaenoyl-CoA CDP dTTP phosphate dehydrogenase: L-glutamyl)-L-glutamate D-glucopyranose maltotetraose hydroxytetracosanoyl- RS03575 phosphate CO H O a 2,3,4-saturated a sugar RS21985 a sugar XMP 2-dehydropantoate THMPT 2 2 acetyl-CoA dCTP HMPREF9474_RS04950 acetyltransferase: fatty acid [acp] N-end rule pathway I (prokaryotic) HMPREF9474_RS06990 13-DPG α-L-fucopyranose CTP leucyl/phenylalanyl-tRNA- a sugar RS22995 a sugar acetyl phosphate a long-linear (S)-3- RS22060 -protein transferase: fucose isomerase: α-D-glucopyranose maltose maltopentaose acetate pentanoyl-CoA an [amino-group carrier protein]-C- maltoheptaose a 3-oxooctadecanoyl- meso- (S)-3-hydroxy-(7Z) (S)-3-hydroxy-(7Z) a negatively 3-(5'-methylthio) an aliphatic phosphoglycerate α-D-glucan γ carboxyphosphinopyruvate 2-hydroxyisobutyramide an mRNA spermine hydroxyhexanoyl- α ω pyrazinamide butan-1-ol HMPREF9474_RS15680 a [protein] HMPREF9474_RS22905 terminal- -(L-ornithyl)-L-glutamate [acp] diaminopimelate -hexadecenoyl-CoA -tetradecenoyl-CoA supercoiled DNA pentylmalate , -diamine an N-terminal kinase: pgk acetate kinase: carboxyvinyl- 3-oxoacyl-ACP reductase: CoA N-terminal L- acetylornithine amidase: 3-hydroxyacyl-CoA 3-hydroxyacyl-CoA spermine/spermidine enoyl-CoA hydratase: DNA topoisomerase I: 3-isopropylmalate spermine/spermidine amidase: alcohol dehydrogenase: a sugar RS23000 a sugar arginyl-[protein] 3-phospho- HMPREF9474_RS06985 carboxyphosphonate HMPREF9474_RS17535 diaminopimelate mRNA interferase PemK: leucyl-L-arginine L-fuculose galactose-1-phosphate 4-alpha-glucanotransferase: 4-alpha-glucanotransferase: butyryl-CoA:acetate aminotransferase: alpha-glucosidase: HMPREF9474_RS05535 dehydrogenase: dehydrogenase: acetyltransferase: HMPREF9474_RS17470 HMPREF9474_RS09545 dehydrogenase: acetyltransferase: HMPREF9474_RS05535 HMPREF9474_RS03355 D-glycerate UDP-glucose 4-epimerase: phosphorylmutase: dehydrogenase: HMPREF9474_RS21490 uridylyltransferase: HMPREF9474_RS02685 HMPREF9474_RS02685 CoA-transferase: HMPREF9474_RS07425 HMPREF9474_RS19085 beta-ketoacyl- [+ 2 isozymes] HMPREF9474_RS03205 HMPREF9474_RS03205 HMPREF9474_RS05795 [+ 6 isozymes] HMPREF9474_RS13955 HMPREF9474_RS05795 [+ 2 isozymes] [+ 6 isozymes] RS02930 HMPREF9474_RS07390 acetate an [amino-group carrier protein]- HMPREF9474_RS18800 HMPREF9474_RS21115 [+ 2 isozymes] leucyl/phenylalanyl-tRNA- 2,3-bisphosphoglycerate- ACP reductase: 2-hydroxy-2- 3-oxo-(7Z)- 3-oxo-(7Z)- 1 8-(methylthio)- an aliphatic N- pyrazine-2- formate formate HMPREF9474_RS05750 HMPREF9474_RS17405 C-terminal-γ-(L-glutamate 5- (S)-2,3,4,5- an mRNA fragment N -acetylspermine trans-hex-2- a relaxed DNA butan-1-al RS17580 -protein transferase: independent phosphinopyruvate a (3R)-3- HMPREF9474_RS03800 methylpropanoate tetrahydrodipicolinate hexadecenoyl-CoA tetradecenoyl-CoA enoyl-CoA 2-oxooctanoate acetyl-diamine carboxylate nitrite nitrite a [protein] semialdehyde-2-yl)-L-glutamate an N-terminal HMPREF9474_RS15680 phosphoglycerate mutase: L-fuculose α-D-glucopyranose a short glucan a short glucan D-glucopyranose maltohexaose D-glucopyranose maltohexaose hydroxyoctadecanoyl- N-terminal L- α L-lysyl-[protein] HMPREF9474_RS04925 1-phosphate 1-phosphate UDP- -D-galactose acetyl-CoA pentanoate [acp] RS10200 leucyl-L-lysine cofactor-independent RS17745 phosphoglycerate mutase: phosphoglucomutase: HMPREF9474_RS20965 HMPREF9474_RS17085 a 3,5,7,9,11,13,15- D-glucopyranose a maltodextrin maltose maltotetraose an [amino-group carrier protein]-C- a single 2-hydroxy-2- (S)-3-hydroxy-(9Z) 3-(6'-methylthio) indole-3- a supercoiled a secondary fumarate asp γ L,L-diaminopimelate hepta-oxo- 4-guanidinobutyramide carboxynorspermidine a DNA segment hydrogenobyrinate benzoyl-CoA acetamide 2-phospho- DHAP (S)-lactaldehyde D-glucopyranose terminal- -(L-glutamyl)-L-glutamate stranded DNA methylpropanenitrile -hexadecenoyl-CoA hexylmalate acetonitrile duplex DNA alcohol RS17505 D-glycerate diaminopimelate epimerase: hexadecanoyl-[PKS-acp]aldo/keto reductase: amidase: carboxynorspermidine nitrilase: 3-hydroxyacyl-CoA recombinase RecD: cobyrinic acid a,c- 4-hydroxybenzoyl- 3-isopropylmalate nitrilase: helicase SNF2: alcohol dehydrogenase: amidase: 6-phosphate acetylglutamate kinase: endonuclease IV: enolase: HMPREF9474_RS06480 HMPREF9474_RS01430 HMPREF9474_RS05535 decarboxylase: HMPREF9474_RS09205 dehydrogenase: HMPREF9474_RS15190 diamide synthase: CoA reductase: dehydrogenase: HMPREF9474_RS09205 HMPREF9474_RS12160 HMPREF9474_RS09570 HMPREF9474_RS05535 4-alpha-glucanotransferase: 4-alpha-glucanotransferase: HMPREF9474_RS07430 HMPREF9474_RS00035 RS23075 HMPREF9474_RS18175 L-aspartate oxidase: diaminopimelate epimerase: aldo/keto reductase: [+ 2 isozymes] HMPREF9474_RS18855 [+ 5 isozymes] HMPREF9474_RS03205 [+ 16 isozymes] HMPREF9474_RS09370 HMPREF9474_RS08200 HMPREF9474_RS13955 [+ 5 isozymes] [+ 8 isozymes] [+ 4 isozymes] [+ 2 isozymes] HMPREF9474_RS02685 HMPREF9474_RS02685 an [amino-group carrier protein]- phosphopyruvate HMPREF9474_RS14605 HMPREF9474_RS06495 9-hydroxy-3,5,7,11,13,15-HMPREF9474_RS04420 2-hydroxy-2- 3-oxo-(9Z)- a DNA segment in hydrogenobyrinate 4-hydroxybenzoyl- 9-(methylthio)- a single C-terminal-γ-(5-phospho- a 5'-phosphooligonucleotide 4-guanidinobutanoate norspermidine indole-3-acetate a ketone acetate RS04930 hydratase: eno meso-diaminopimelate hexaoxohexadecanoyl- methylpropanoate hexadecenoyl-CoA reverse orientation a,c-diamide CoA 2-oxononanoate stranded DNA L-sorbose degradation fructose degradation lactose degradation III L-glutamyl)-L-glutamate phosphoenol a maltodextrin maltose D-glucopyranose maltopentaose [PKS-acp] 2-iminosuccinate succinate pyruvate keto-L-sorbose β-D-fructofuranose lactose RS21300 1-phosphate 1-phosphate beta-galactosidase: pyruvate kinase: L-sorbose 1- 1-phosphofructokinase: RS12820 HMPREF9474_RS05080 phosphate reductase: HMPREF9474_RS02900 HMPREF9474_RS03500 3'-dephospho- (3R)-3-hydroxy-2-oxo-4 (2E,6Z,9Z,12Z,15Z,18Z) (S)-3-hydroxy-(11Z) (S)-3-hydroxy-(5Z) a uridine 55 3-(3'-methylthio) (2R,3S)-3- HMPREF9474_RS10360 beta-galactosidase: D-glucopyranose maltotetraose maltotriose a glucan ATP carboxyphosphonoenolpyruvate 2-trans-tetradecenoyl-CoA uroporphyrinogen-III trans-dec-2-enoyl-CoA D-glycerate putrescine meso-tartrate a kanamycin acrylamide D-sorbitol 1-phosphofructokinase: CoA phosphonooxybutanoate -tetracosahexaenoyl-CoA -octadecenoyl-CoA -dodecenoyl-CoA in tRNA propylmalate isopropylmalate pyruvate HMPREF9474_RS03610 6-phosphate HMPREF9474_RS10275 carboxyvinyl- 3-phosphoserine/ enoyl-CoA hydratase: enoyl-CoA hydratase: uroporphyrinogen enoyl-CoA hydratase: glycerate dehydrogenase: 3-hydroxyacyl-CoA spermine/spermidine 3-hydroxyacyl-CoA tRNA pseudouridine(55) 3-isopropylmalate 3-isopropylmalate aminoglycoside amidase: fructose 1,6- β-D-galactose tartrate dehydrogenase: RS21135 Detoxification carboxyphosphonate phosphohydroxythreonine HMPREF9474_RS17470 HMPREF9474_RS17470 decarboxylase: HMPREF9474_RS17470 HMPREF9474_RS00725 dehydrogenase: acetyltransferase: dehydrogenase: synthase: dehydrogenase: dehydrogenase: phosphotransferase: HMPREF9474_RS05535 RS14460 bisphosphate 4-alpha-glucanotransferase: 4-alpha-glucanotransferase: dephospho-CoA kinase: phosphorylmutase: aminotransferase: HMPREF9474_RS06470 HMPREF9474_RS11925 lactate dehydrogenase: HMPREF9474_RS02685 HMPREF9474_RS02685 [+ 2 isozymes] [+ 2 isozymes] HMPREF9474_RS03015 [+ 2 isozymes] [+ 3 isozymes] HMPREF9474_RS03205 HMPREF9474_RS05795 HMPREF9474_RS03205 HMPREF9474_RS13670 HMPREF9474_RS13955 HMPREF9474_RS13955 [+ 2 isozymes] HMPREF9474_RS06335 HMPREF9474_RS07020 HMPREF9474_RS18800 HMPREF9474_RS13970 (S)-3- (3S)-hydroxy- (S)-3- 3-oxo-(11Z)- 3-oxo-(5Z)- a pseudouridine 55 6-(methylthio)- 4-methyl-2- 2-hydroxy-3- a kanamycin keto-D-fructose reactive oxygen 4-phospho- (6Z,9Z,12Z,15Z,18Z)- coproporphyrinogen III hydroxypyruvate N-acetylputrescine 3'-phosphate acrylate [+ 2 isozymes] oxidized GTP and dGTP detoxification arginine dependent phosphinopyruvate hydroxytetradecanoyl-CoA hydroxydecanoyl-CoA octadecenoyl-CoA dodecenoyl-CoA in tRNA 2-oxohexanoate oxopentanoate oxosuccinate + + (R)-lactate 6-phosphate species degradation hydroxy-L-threonine tetracosapentaenoyl-CoA H RS03165 H acid resistance maltose maltotriose a glucan D-glucopyranose RS06640 ADP coenzyme A H + (S)-lactate superoxide dGTP GTP arg superoxide dismutase: 6 RS11220 arginine decarboxylase: a plant soluble an N -L- a [pyruvate dehydrogenase 967 a debranched 516 HMPREF9474_RS04210 α dTDP-thomosamine a cytosine RNase G degradation D-sedoheptulose CDP-α-D-glucose a uridine HMPREF9474_RS18830 D-glucopyranose maltose maltohexaose threonylcarbamoyladenine 37 carboxyphosphonoenolpyruvate E2 protein] N 6 - an -limit dextrin a uridine in tRNA α maltose L-iditol 3-ethylmalate cellulose ATP RS21255 8-oxo-dGTP 8-oxo-GTP heteroglycan dTDP-4-amino-4,6- in 16S rRNA substrate mRNA 7-phosphate -limit dextrin CDP-glucose 4,6- in 16S rRNA hydrogen agmatine in tRNA carboxyvinyl- dihydrolipoyl-L-lysine glycosyl transferase peroxide tRNA dihydrolipoyl 4-alpha-glucanotransferase: dideoxygalactose 16S rRNA (cytosine(967) phosphoheptose tRNA dihydrouridine dehydratase: pseudouridine synthase: alpha-glucosidase: sorbitol dehydrogenase: 3-isopropylmalate cellulase: 7,8-dihydro-8-oxoguanine threonylcarbamoyladenosine carboxyphosphonate -C(5))-methyltransferase: ribonuclease G: isomerase: synthase DusB: family 35: HMPREF9474_RS09865 dehydrogenase: adenylate cyclase: 4-alpha-glucanotransferase: 4-alpha-glucanotransferase: dehydrogenase: HMPREF9474_RS02685 transaminase: HMPREF9474_RS20370 HMPREF9474_RS01550 HMPREF9474_RS19085 HMPREF9474_RS20210 HMPREF9474_RS01600 HMPREF9474_RS08140 triphosphatase: dehydratase: phosphorylmutase: HMPREF9474_RS01545 HMPREF9474_RS21015 HMPREF9474_RS01575 HMPREF9474_RS15160 HMPREF9474_RS21555 CDP-4-dehydro- [+ 2 isozymes] HMPREF9474_RS13955 HMPREF9474_RS02685 HMPREF9474_RS02685 HMPREF9474_RS08970 a α-limit dextrin α RS21085 HMPREF9474_RS02770 6 HMPREF9474_RS10210 HMPREF9474_RS18800 967 D-glycero-D-manno- -D-glucopyranose RS16755 a cyclic N -L- a [pyruvate dehydrogenase dTDP-4-dehydro-6- a 5-methylcytosine a 5,6-dihydrouridine 6-deoxy-D-glucose a 16S rRNA D-glucopyranose keto-L-sorbose a cellodextrin with short branches an mRNA fragment 1-phosphate 516 2-oxovalerate cyclic-AMP 8-oxo-GMP carboxyphosphinopyruvate 6 α heptose 7-phosphate 8-oxo-dGMP threonylcarbamoyladenosine E2 protein] N -lipoyl-L-lysine deoxy- -D-glucopyranose in 16S rRNA in tRNA pseudouridine O H O hydroxyl radical a plant soluble 37 in tRNA 2 2 maltose maltoheptaose D-glucopyranose a branched- heteroglycan chain RS23920 RS22240 amino acid a dicarboxylate an amino a dicarboxylate an amino D-cellobiose a β- a branched- a branched- cytosine a basic an amino acid acid an amino acid acid L-proline betaine (R)- a purine methyl-β-D- glutamate D-glucose 6- D-fructose p-aminobenzoyl 6'- glucoside 6- a sugar 6- a sugar 6- an an chain chain a C4- lactose 6'- a hydroxamate glycine glycine glycine glycine a polyisoprenyl- D-mannitol a dicarboxylate a monosaccharide a macrolide L-carnitine amino acid molybdate molybdate a cation a cation a cation a cation a cation a cation a cation glutathione glutathione D-galactose 3+ glycine betaine propanoate uracil pantothenate galactoside phosphate 1-phosphate cytosine glutamate chromate phosphate phosphate phosphate phosphate a phospholipid a phospholipid oligopeptide oligopeptide predicted amino acid amino acid a cation dicarboxylate phosphate Fe betaine betaine betaine betaine teichoic acid 1-phosphate xanthine ABC transporter RS06550 RS13885 RS19510 RS16410 RS11325 RS08550 RS11685 RS01325 RS13830 RS04040 RS17855 RS02720 RS21925 RS01580 RS12880 RS20455 RS09325 RS01025 RS01270 RS23635 RS04825 RS04555 RS11170 RS09010 RS02670 RS09500 RS04150 RS12330 RS04260 RS18520 RS02915 RS11290 RS08150 RS07300 RS06525 RS10280 RS00935 RS10005 RS23770 RS09135 RS01095 RS05695 RS13695 RS05730 RS10355 RS08940 RS01315 RS19380 RS18300 of a RS14390 RS15070 RS07785 RS07790 RS02440 RS09210 RS11205 RS02495 RS01505 RS09255 RS01795 RS02780 RS08025 RS23460 RS18770 RS18290 RS17510 RS08165 RS18320 RS20060 RS13495 RS03650 RS03630 RS07725 RS21635 RS01870 RS20300 RS12245 RS18435 RS10515 RS08090 RS19410 RS12960 RS04635 RS12395 RS09725 RS22795 RS10245 RS02090 RS18990 RS13505 RS05895 RS15285 RS15045 RS07460 RS11255 RS05960 RS22825 RS06855 RS10345 RS17430 RS11755 RS01865 RS04575 RS03075 RS10995 RS20005 RS09860 RS18440 RS22000 RS13140 RS03030 RS16150 RS11905 RS05965 RS10605 RS09505 RS05765 RS18395 RS03950 RS10520 RS02870 RS05680 RS10430 branched- chain amino acid glycine a phospholipid a phospholipid betaine

β (R)- methyl- -D- cytosine p-aminobenzoyl β an an a branched- a branched- a branched- a C4- a hydroxamate glycine glycine glycine a polyisoprenyl- uracil a dicarboxylate a monosaccharide a macrolide D-glucose D-fructose D-cellobiose L-carnitine a -glucoside a basic a sugar a sugar molybdate molybdate a cation a cation a cation lactose glutathione glutathione D-galactose L-proline betaine D-mannitol propanoate pantothenate cytosine galactoside glutamate glutamate oligopeptide oligopeptide chain chain chain a dicarboxylate a dicarboxylate dicarboxylate Fe 3+ betaine betaine betaine teichoic acid xanthine chromate amino acid a cation an aminoa cation a cation an aminoa cation a cation glycine betaine a purine amino acid amino acid amino acid an amino acid acid an amino acid acid Copyright SRI International 2016. All Rights Reserved. This diagram was automatically generated by SRI International Pathway Tools version 25.0, authors S. Paley and P.D. Karp.