Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis Elegans
bioRxiv preprint doi: https://doi.org/10.1101/2020.11.10.377143; this version posted November 10, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans Ricardo Laranjeiro1, Girish Harinath1, Amelia K. Pollard2, Christopher J. Gaffney3,4, Colleen S. Deane3, Siva A. Vanapalli5, Timothy Etheridge3, Nathaniel J. Szewczyk2, and Monica Driscoll1 1 Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ, USA 2 MRC Versus Arthritis Centre for Musculoskeletal Ageing Research and NIHR Nottingham BRC, University of Nottingham, Medical School Royal Derby Hospital, Derby, United Kingdom 3 Sport and Health Sciences, University of Exeter, Exeter, United Kingdom 4 Lancaster Medical School, Health Innovation One, Lancaster University, Lancaster, United Kingdom 5 Department of Chemical Engineering, Texas Tech University, Lubbock, TX, USA 1 bioRxiv preprint doi: https://doi.org/10.1101/2020.11.10.377143; this version posted November 10, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Abstract Extended space travel, such as crewed missions to Mars and beyond, is a goal for both government space agencies and private companies. Research over the past decades, however, has shown that spaceflight poses risks to human health, including negative effects on musculoskeletal, cardiovascular, and immune systems.
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