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MDM Online: Quedlinburg/Harz
PR O D U K TIO N SZEN TR U M Q U ED LIN BU R G /H A R Z IN H A LT Produktionszentrum Quedlinburg/Harz 2 Lage in Mitteldeutschland 3 Übersicht 4 Antragstellung 5 Adressen Locations und Dienstleister 6 Immobilien, Hallen und Produktionsbüros 6 Unterkünfte und Hotels 6 Gastroverzeichnis 7 Notdienste und Gesundheitsversorgung 7 Energie, Wasser, Abwasser und Abfall 7 Verkehrsinformationen 7 Kinos und Theater 8 Regionale Pressekontakte 9 Referenzprojekte 10 Kontakt & Impressum 11 Seite 1 von 11 PR O D U K TIO N SZEN TR U M Q U ED LIN BU R G /H A R Z OBERBÜRGERMEISTER Frank Ruch Das Produktionszentrum Quedlinburg liegt im nordöstlichen Harzvorland GEOGRAFISCHE LAGE 10° 09` östliche Länge im geschichtsträchtigen Harzer Städtedreieck Wernigerode-Halberstadt- 51° 48` nördliche Breite Quedlinburg. In einer Reichweite von einer Stunde Fahrtzeit sind der FLÄCHE DES STADTGEBIETES 102 km2 Harz, das Harzvorland sowie Magdeburg und Halle gut erreichbar. Das nördliche Harzvorland zeigt sich als sanft gewellte Landschaft mit EINWOHNER 23.800 weitläufigen Ackerflächen, Höhenzügen und Flussniederungen, die von ENTFERNUNGEN Hannover 135 km (01:40 h) der Landwirtschaft bestimmt wird. Niederungs-und Wiesenlandschaften Magdeburg 59 km (00:50 h) mit schilf- und weidengesäumten Gräben, alte Buchenwälder und die Halle 83 km (01:10 h) bizarren Felsformationen der Teufelsmauer sind Teil der Leipzig 122 km (01:30 h) wildromantischen Harzer Natur. Dresden 146 km (01:30 h) Besonderes Merkmal ländlicher und städtischer Baukultur ist das vielfältig Erfurt 130 km (02:00 h) genutzte Fachwerk, welches den Großteil der Region bestimmt. Die historischen Zentren weltlicher und sakraler Macht stellen sich als bedeutende Sandsteinbauwerke dar. -
The Nobel Prize Sweden.Se
Facts about Sweden: The Nobel Prize sweden.se The Nobel Prize – the award that captures the world’s attention The Nobel Prize is considered the most prestigious award in the world. Prize- winning discoveries include X-rays, radioactivity and penicillin. Peace Laureates include Nelson Mandela and the 14th Dalai Lama. Nobel Laureates in Literature, including Gabriel García Márquez and Doris Lessing, have thrilled readers with works such as 'One Hundred Years of Solitude' and 'The Grass is Singing'. Every year in early October, the world turns Nobel Day is 10 December. For the prize its gaze towards Sweden and Norway as the winners, it is the crowning point of a week Nobel Laureates are announced in Stockholm of speeches, conferences and receptions. and Oslo. Millions of people visit the website At the Nobel Prize Award Ceremony in of the Nobel Foundation during this time. Stockholm on that day, the Laureates in The Nobel Prize has been awarded to Physics, Chemistry, Physiology or Medicine, people and organisations every year since and Literature receive a medal from the 1901 (with a few exceptions such as during King of Sweden, as well as a diploma and The Nobel Banquet is World War II) for achievements in physics, a cash award. The ceremony is followed a magnificent party held chemistry, physiology or medicine, literature by a gala banquet. The Nobel Peace Prize at Stockholm City Hall. and peace. is awarded in Oslo the same day. Photo: Henrik Montgomery/TT Henrik Photo: Facts about Sweden: The Nobel Prize sweden.se Prize in Economic Sciences prize ceremonies. -
EMBC Annual Report 2007
EMBO | EMBC annual report 2007 EUROPEAN MOLECULAR BIOLOGY ORGANIZATION | EUROPEAN MOLECULAR BIOLOGY CONFERENCE EMBO | EMBC table of contents introduction preface by Hermann Bujard, EMBO 4 preface by Tim Hunt and Christiane Nüsslein-Volhard, EMBO Council 6 preface by Marja Makarow and Isabella Beretta, EMBC 7 past & present timeline 10 brief history 11 EMBO | EMBC | EMBL aims 12 EMBO actions 2007 15 EMBC actions 2007 17 EMBO & EMBC programmes and activities fellowship programme 20 courses & workshops programme 21 young investigator programme 22 installation grants 23 science & society programme 24 electronic information programme 25 EMBO activities The EMBO Journal 28 EMBO reports 29 Molecular Systems Biology 30 journal subject categories 31 national science reviews 32 women in science 33 gold medal 34 award for communication in the life sciences 35 plenary lectures 36 communications 37 European Life Sciences Forum (ELSF) 38 ➔ 2 table of contents appendix EMBC delegates and advisers 42 EMBC scale of contributions 49 EMBO council members 2007 50 EMBO committee members & auditors 2007 51 EMBO council members 2008 52 EMBO committee members & auditors 2008 53 EMBO members elected in 2007 54 advisory editorial boards & senior editors 2007 64 long-term fellowship awards 2007 66 long-term fellowships: statistics 82 long-term fellowships 2007: geographical distribution 84 short-term fellowship awards 2007 86 short-term fellowships: statistics 104 short-term fellowships 2007: geographical distribution 106 young investigators 2007 108 installation -
REFORM, RESISTANCE and REVOLUTION in the OTHER GERMANY By
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Birmingham Research Archive, E-theses Repository RETHINKING THE GDR OPPOSITION: REFORM, RESISTANCE AND REVOLUTION IN THE OTHER GERMANY by ALEXANDER D. BROWN A thesis submitted to the University of Birmingham for the degree of DOCTOR OF PHILOSOPHY Department of Modern Languages School of Languages, Cultures, Art History and Music University of Birmingham January 2019 University of Birmingham Research Archive e-theses repository This unpublished thesis/dissertation is copyright of the author and/or third parties. The intellectual property rights of the author or third parties in respect of this work are as defined by The Copyright Designs and Patents Act 1988 or as modified by any successor legislation. Any use made of information contained in this thesis/dissertation must be in accordance with that legislation and must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the permission of the copyright holder. Abstract The following thesis looks at the subject of communist-oriented opposition in the GDR. More specifically, it considers how this phenomenon has been reconstructed in the state-mandated memory landscape of the Federal Republic of Germany since unification in 1990. It does so by presenting three case studies of particular representative value. The first looks at the former member of the Politbüro Paul Merker and how his entanglement in questions surrounding antifascism and antisemitism in the 1950s has become a significant trope in narratives of national (de-)legitimisation since 1990. The second delves into the phenomenon of the dissident through the aperture of prominent singer-songwriter, Wolf Biermann, who was famously exiled in 1976. -
EMBO Facts & Figures
excellence in life sciences Reykjavik Helsinki Oslo Stockholm Tallinn EMBO facts & figures & EMBO facts Copenhagen Dublin Amsterdam Berlin Warsaw London Brussels Prague Luxembourg Paris Vienna Bratislava Budapest Bern Ljubljana Zagreb Rome Madrid Ankara Lisbon Athens Jerusalem EMBO facts & figures HIGHLIGHTS CONTACT EMBO & EMBC EMBO Long-Term Fellowships Five Advanced Fellows are selected (page ). Long-Term and Short-Term Fellowships are awarded. The Fellows’ EMBO Young Investigators Meeting is held in Heidelberg in June . EMBO Installation Grants New EMBO Members & EMBO elects new members (page ), selects Young EMBO Women in Science Young Investigators Investigators (page ) and eight Installation Grantees Gerlind Wallon EMBO Scientific Publications (page ). Programme Manager Bernd Pulverer S Maria Leptin Deputy Director Head A EMBO Science Policy Issues report on quotas in academia to assure gender balance. R EMBO Director + + A Conducts workshops on emerging biotechnologies and on H T cognitive genomics. Gives invited talks at US National Academy E IC of Sciences, International Summit on Human Genome Editing, I H 5 D MAN 201 O N Washington, DC.; World Congress on Research Integrity, Rio de A M Janeiro; International Scienti c Advisory Board for the Centre for Eilish Craddock IT 2 015 Mammalian Synthetic Biology, Edinburgh. Personal Assistant to EMBO Fellowships EMBO Scientific Publications EMBO Gold Medal Sarah Teichmann and Ido Amit receive the EMBO Gold the EMBO Director David del Álamo Thomas Lemberger Medal (page ). + Programme Manager Deputy Head EMBO Global Activities India and Singapore sign agreements to become EMBC Associate + + Member States. EMBO Courses & Workshops More than , participants from countries attend 6th scienti c events (page ); participants attend EMBO Laboratory Management Courses (page ); rst online course EMBO Courses & Workshops recorded in collaboration with iBiology. -
Nobel Prize Physicists Meet at Lindau
From 28 June to 2 July 1971 the German island town of Lindau in Nobel Prize Physicists Lake Constance close to the Austrian and Swiss borders was host to a gathering of illustrious men of meet at Lindau science when, for the 21st time, Nobel Laureates held their reunion there. The success of the first Lindau reunion (1951) of Nobel Prize win ners in medicine had inspired the organizers to invite the chemists and W. S. Newman the physicists in turn in subsequent years. After the first three-year cycle the United Kingdom, and an audience the dates of historical events. These it was decided to let students and of more than 500 from 8 countries deviations in the radiocarbon time young scientists also attend the daily filled the elegant Stadttheater. scale are due to changes in incident meetings so they could encounter The programme consisted of a num cosmic radiation (producing the these eminent men on an informal ber of lectures in the mornings, two carbon isotopes) brought about by and personal level. For the Nobel social functions, a platform dis variations in the geomagnetic field. Laureates too the Lindau gatherings cussion, an informal reunion between Thus chemistry may reveal man soon became an agreeable occasion students and Nobel Laureates and, kind’s remote past whereas its long for making or renewing acquain on the last day, the traditional term future could well be shaped by tances with their contemporaries, un steamer excursion on Lake Cons the developments mentioned by trammelled by the formalities of the tance to the island of Mainau belong Mössbauer, viz. -
A Nobel Synthesis
MILESTONES IN CHEMISTRY Ian Grayson A nobel synthesis IAN GRAYSON Evonik Degussa GmbH, Rodenbacher Chaussee 4, Hanau-Wolfgang, 63457, Germany he first Nobel Prize for chemistry was because it is a scientific challenge, as he awarded in 1901 (to Jacobus van’t Hoff). described in his Nobel lecture: “The synthesis T Up to 2010, the chemistry prize has been of brazilin would have no industrial value; awarded 102 times, to 160 laureates, of whom its biological importance is problematical, only four have been women (1). The most but it is worth while to attempt it for the prominent area for awarding the Nobel Prize sufficient reason that we have no idea how for chemistry has been in organic chemistry, in to accomplish the task” (4). which the Nobel committee includes natural Continuing the list of Nobel Laureates in products, synthesis, catalysis, and polymers. organic synthesis we arrive next at R. B. This amounts to 24 of the prizes. Reading the Woodward. Considered by many the greatest achievements of the earlier organic chemists organic chemist of the 20th century, he who were recipients of the prize, we see that devised syntheses of numerous natural they were drawn to synthesis by the structural Alfred Nobel, 1833-1896 products, including lysergic acid, quinine, analysis and characterisation of natural cortisone and strychnine (Figure 1). 6 compounds. In order to prove the structure conclusively, some In collaboration with Albert Eschenmoser, he achieved the synthesis, even if only a partial synthesis, had to be attempted. It is synthesis of vitamin B12, a mammoth task involving nearly 100 impressive to read of some of the structures which were deduced students and post-docs over many years. -
Dissertation
Regulation of gene silencing: From microRNA biogenesis to post-translational modifications of TNRC6 complexes DISSERTATION zur Erlangung des DOKTORGRADES DER NATURWISSENSCHAFTEN (Dr. rer. nat.) der Fakultät Biologie und Vorklinische Medizin der Universität Regensburg vorgelegt von Johannes Danner aus Eggenfelden im Jahr 2017 Das Promotionsgesuch wurde eingereicht am: 12.09.2017 Die Arbeit wurde angeleitet von: Prof. Dr. Gunter Meister Johannes Danner Summary ‘From microRNA biogenesis to post-translational modifications of TNRC6 complexes’ summarizes the two main projects, beginning with the influence of specific RNA binding proteins on miRNA biogenesis processes. The fate of the mature miRNA is determined by the incorporation into Argonaute proteins followed by a complex formation with TNRC6 proteins as core molecules of gene silencing complexes. miRNAs are transcribed as stem-loop structured primary transcripts (pri-miRNA) by Pol II. The further nuclear processing is carried out by the microprocessor complex containing the RNase III enzyme Drosha, which cleaves the pri-miRNA to precursor-miRNA (pre-miRNA). After Exportin-5 mediated transport of the pre-miRNA to the cytoplasm, the RNase III enzyme Dicer cleaves off the terminal loop resulting in a 21-24 nt long double-stranded RNA. One of the strands is incorporated in the RNA-induced silencing complex (RISC), where it directly interacts with a member of the Argonaute protein family. The miRNA guides the mature RISC complex to partially complementary target sites on mRNAs leading to gene silencing. During this process TNRC6 proteins interact with Argonaute and recruit additional factors to mediate translational repression and target mRNA destabilization through deadenylation and decapping leading to mRNA decay. -
The GW182 Protein Family in Animal Cells: New Insights Into Domains Required for Mirna-Mediated Gene Silencing
Downloaded from rnajournal.cshlp.org on September 30, 2021 - Published by Cold Spring Harbor Laboratory Press REVIEW The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing ANA EULALIO, FELIX TRITSCHLER, and ELISA IZAURRALDE Department of Biochemistry, Max Planck Institute for Developmental Biology, D-72076 Tu¨bingen, Germany ABSTRACT GW182 family proteins interact directly with Argonaute proteins and are required for miRNA-mediated gene silencing in animal cells. The domains of the GW182 proteins have recently been studied to determine their role in silencing. These studies revealed that the middle and C-terminal regions function as an autonomous domain with a repressive function that is independent of both the interaction with Argonaute proteins and of P-body localization. Such findings reinforce the idea that GW182 proteins are key components of miRNA repressor complexes in metazoa. Keywords: Argonaute; GW182; miRNAs; mRNA decay; P-bodies; RBD; RRM; TNRC6A INTRODUCTION are conserved in diverse organisms (for review, see Carthew and Sontheimer 2009; Kim et al. 2009). Among proteins MicroRNAs are genome-encoded small RNAs that post- that play a general role, those in the GW182 family have transcriptionally regulate gene expression and play critical emerged as key components of miRNA repressive com- roles in a wide range of important biological processes plexes in animal cells (for review, see Ding and Han 2007; including cell growth, division and differentiation, and Eulalio et al. 2007a, 2008a). organism metabolism and development. About 500–1000 The precise molecular function of GW182 proteins in the miRNA genes exist in vertebrates and plants, and 100 in miRNA pathway is not fully understood; yet, recent studies invertebrates, and each miRNA is predicted to have target have provided new insights into their role in silencing sites in hundreds of mRNAs, suggesting that miRNAs (Chekulaeva et al. -
Unwinding the Differences of the Mammalian PERIOD Clock Proteins from Crystal Structure to Cellular Function
Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function Nicole Kuceraa,1, Ira Schmalenb, Sven Henniga,1, Rupert Öllingerc, Holger M. Straussd,2, Astrid Grudzieckic, Caroline Wieczoreka,3, Achim Kramerc, and Eva Wolfb,4,5 aMax Planck Institute of Molecular Physiology, Department of Structural Biology, Otto-Hahn-Strasse 11, 44227 Dortmund, Germany; bMax Planck Institute of Biochemistry, Department of Structural Cell Biology, Am Klopferspitz 18, 82152 Martinsried, Germany; dNanolytics, Gesellschaft für Kolloidanalytik mbH, Am Mühlenberg 11, 14476 Potsdam, Germany; and cLaboratory of Chronobiology, Charité—Universitätsmedizin Berlin, 10098 Berlin, Hessische Strasse 3-4, 10115 Berlin, Germany Edited by Gregory A. Petsko, Brandeis University, Waltham, MA, and approved January 4, 2012 (received for review August 16, 2011) The three PERIOD homologues mPER1, mPER2, and mPER3 consti- the mBMAL1/mCLOCK transcription factor complex. Addition- tute central components of the mammalian circadian clock. They ally, the PAS domains of NPAS2, mCLOCK, and mPER2 have been contain two PAS (PER-ARNT-SIM) domains (PAS-A and PAS-B), which reportedtobindheme(13–16).Inthecircadianclock,mPER1and mediate homo- and heterodimeric mPER-mPER interactions as well mPER2 proteins are found in large protein complexes, likely estab- as interactions with transcription factors and kinases. Here we pre- lishing multiple interactions via their PAS domains, the central sent crystal structures of PAS domain fragments of mPER1 and CKIε∕δ binding domain and the C-terminal mCRY binding region mPER3 and compare them with the previously reported mPER2 (17–19). structure. The structures reveal homodimers, which are mediated Studies with mPER knockout mice showed that mPER1 and by interactions of the PAS-B β-sheet surface including a highly con- mPER2 are more essential for circadian rhythmicity than mPER3 served tryptophan (Trp448mPER1, Trp419mPER2, Trp359mPER3). -
Naumburg/Zeitz 2 Lage in Mitteldeutschland 3 Übersicht Burgenlandkreis 4 Übersicht Naumburg 5 Übersicht Zeitz 6 Antragstellung Naumburg 7 Antragstellung Zeitz 8
PR O D U K TIO N SZEN TR U M N A U M BU R G /ZEITZ IN H A LT Produktionszentrum Naumburg/Zeitz 2 Lage in Mitteldeutschland 3 Übersicht Burgenlandkreis 4 Übersicht Naumburg 5 Übersicht Zeitz 6 Antragstellung Naumburg 7 Antragstellung Zeitz 8 Adressen Locations und Dienstleister 9 Immobilien, Hallen und Produktionsbüros 9 Unterkünfte und Hotels 9 Gastroverzeichnis 9 Notdienste und Gesundheitsversorgung 9 Energie, Wasser, Abwasser und Abfall 9 Verkehrsinformationen 10 Kinos und Theater 10 Regionale Pressekontakte 11 Referenzprojekte 12 Kontakt & Impressum 13 Seite 1 von 13 PR O D U K TIO N SZEN TR U M N A U M BU R G /ZEITZ N A U M B U R G OBERBÜRGERMEISTER Bernward Küper Das Produktionszentrum Naumburg/Zeitz liegt im Süden Sachsen- GEOGRAFISCHE LAGE 11° 80` östliche Länge Anhalts. Mit der günstigen Position im Dreiländereck Sachsen, Sachsen- 51° 15` nördliche Breite Anhalt und Thüringen ist das Produktionszentrum über die nahe gelegene A9 hervorragend an Magdeburg, Leipzig und Erfurt angebunden. In einer FLÄCHE DES STADTGEBIETES 123 km2 Reichweite von einer Stunde Fahrtzeit sind u. a. Merseburg und Querfurt, die Weinanbaugebiete der Saale-Unstrut Region und länderübergreifend EINWOHNER 32.150 Städte wie Altenburg, Weimar, Jena und Leipzig gut erreichbar. ENTFERNUNGEN Magdeburg 162 km (01:38 h) Halle 56 km (00:55 h) Zwei landschaftlich sehr verschiedene Gebiete gehen in dieser Region Leipzig 68 km (00:50 h) ineinander über. Die nordöstlich gelegenen Ackerebenen des Altenburg 55 km (01:04 h) Halle/Leipziger Industriegroßraums werden im Wesentlichen durch Gera 61 km (00:48 h) Schichten wie Löß, Moränen und Sander sowie Flussablagerungen und Jena 32 km (00:37 h) Auen gebildet. -
Book Reviews
86 Bull. Hist. Chem., VOLUME 31, Number 2 (2006) BOOK REVIEWS Drug Discovery—A History. Walter Sneader, John Wiley, mercury is particularly interesting. Study of this sub- New York, 2005, Cloth, 468 pp, $65. stance eventually led to the discovery of arsphenamine, an organomercurial used to treat syphilis and much later stimulated the discovery of the potent diuretic ethacrynic I count myself fortunate to own copies of Walter acid. This and other interesting stories set forth in this Sneader’s books on drug discovery: The Evolution of section help us to understand the evolutionary nature of Modern Medicines (1985), Drug Prototypes and Their drug discovery from a historical perspective. Exploitation (1996) and Drug Discovery – A History Part 2 – Drugs from Naturally Occurring Proto- (2005). While it is true that each book generally ad- types. In this section of the book Sneader covers three dresses the topic of drug discovery with significant important topics in the history of drug discovery. Plants, overlap in the material covered, it also is true that the hormones, and microorganisms proved to be rich sources most recent work is much more than a third edition of of new medicines after advances in science permitted an existing book. As the title promises, the focus is on isolation and purification of active components. Here history. Because chemical structures are included with we are provided with the historical background that the text, I found the content of this book to be uniquely led to initial discovery of useful activity, followed by satisfying to a chemist interested in history. The material isolation and purification of the active substance, struc- in this book is organized by the source of drug prototypes ture determination, total synthesis, and in some cases rather then chronological order of discovery or thera- manufacture of the drug.