SPECIAL ISSUE

IMMUNOLOGY 2015 ™

PROGRAM PREVIEW

APRIL 2015

The American Association of Immunologists AAI Annual Meeting May 8-12, 2015 New Orleans, LA www.immunology2015.org Learn greater control in cell culture using Cell-Ess® Serum Replacement

Cell-Ess® serum replacement for more relevant cell culture results

Performance Achieve consistent cell performance not attainable with FBS Convenience More time for discoveries. No more lot testing, heat inactivationtion oorr tthawinghawing Control Defined components. Animal component free. No variabilityy

Visit us at Booth #810 and attend our seminar

Seminar Title Variables in FBS Impact Cell Performance, Reproducibility and Relevant Experimental Results Date Monday, May 11, 2015 10:00 AM - 10:45 AM Room Exhibit Hall – Exhibitor Workshop Let it Grow

www.cell-ess.com | www.essentialpharma.com AAI President’s Invitation to IMMUNOLOGY 2015™

Dear Colleagues, your career. The breadth of the science represented at this meeting will give you an opportunity to learn about areas a am honored to have this bit outside your comfort zone, areas that may, in fact, explain Iopportunity to invite you to attend that experimental result you’ve just not been able to wrap your the upcoming annual meeting brain around. And you will be able to discuss your results with of The American Association of researchers who may interpret your findings in an entirely Immunologists, IMMUNOLOGY different light. Use these precious opportunities to broaden 2015TM, to be held May 8-12 in the your horizons and meet new collaborators. great city of New Orleans. Perhaps So whom do we have to thank for all of this? In addition to Linda A. Sherman like many of you, I have not been to AAI President New Orleans since Hurricane Katrina the Program Committee, we have generous AAI committee devastated this historic city. I hope you are as excited as I am members hosting scientific and career development sessions, to visit this much beloved venue that, for me, brings back numerous Guest Societies preparing workshops and symposia, many happy memories. Where else but “The Big Easy” can and, as importantly, the many hard working AAI staff, led by you dance in the streets to music wafting from jazz halls along the incomparable Michele Hogan, who plan and execute the Bourbon Street? The distinctive New Orleans musical and perfect meeting each year. I believe their enthusiasm for our culinary traditions will be highlighted at our Opening Night exciting venue has led them to outdo themselves this year, Welcome Reception and our Gala, thanks to the generous and I hope you will join me as we feast with our friends and corporate support of eBioscience and BioLegend, respectively. colleagues on great jazz, great food, and great science! The zydeco and jazz music, Mardi Gras psychics and jesters, Laissez les bons temps rouler! and the flavors of New Orleans cuisine should prepare you for our stimulating scientific program. Linda A. Sherman Linda A. Sherman Our Program Committee, led by Wendy Havran, has put AAI President together an exciting meeting featuring a broad range of topical subjects. In addition to the many plenary lectures, symposia, workshops, and nearly 1,700 posters, they are also reprising the highly successful “Back to School” workshop—covering the topics and techniques we all need to learn in order to stay abreast of some of the fastest moving fields. We will also have numerous workshops designed to help you chart a successful career. These will include sessions on sources of alternative funding, successful postdoc fellowships, NIH grant applications, and job interviews. And there will be great networking opportunities at careers roundtables.

This brings me to the important issue of why attending the annual AAI meeting is such a unique opportunity for you. You will learn great science and meet people who will influence

In This Issue

3 AAI President’s Invitation 11 2015 AAI Career Awardee 27 2015 Annual Meeting 64 2015 AAI Introductory Letter Profiles Preview Immunology Course Lineup

5 Focus on Public Affairs 18 Members in the News: 30 2015 Meeting Sponsors 65 2015 AAI Trainee Abstract John Kappler and Poster Awardees 9 AAI Travel for Techniques Philippa Marrack 56 2015 Meeting Exhibitors Award Program Update Jeffrey Ravetch 70 2015 AAI Advanced 63 AAI Early/Mid-Career Immunology Course Lineup Achievement Awardees www.aai.org AAI Newsletter 3 Proud Platinum Sponsor of IMMUNOLOGY 2015™

Mechanisms of Cell Death Visit BioLegend at booth #806 Receive our complimentary new posters, enter our prize drawings.

Exhibitor Workshops: Dendritic Cell, Monocyte, and Macrophage Biology Saturday, May 9, 1:45 pm Workshop Room 1: MojoSort™, a versatile nanoparticle for magnetic isolation of cells with high purity, yield, and preserved functionality. Miguel Tam, Ph.D., Product Manager, BioLegend

Regulatory T Cells – New Update! Sunday, May 10, 11:15 am Workshop Room 2: LEGENDplex™: A More Consistent and Economical Multiplex Solution for Biomarker Assays Shaoquan Ji, Ph.D., Head of ELISA and Multiplex Technologies, BioLegend

Cancer Immunoediting – New Update! Prize Drawings: Nine Chances to win a $100 Amazon Gift Card. Exhibitor Workshop (Tam 5/9): 3 winners. Exhibitor Workshop (Ji 5/10): 3 winners. Booth Survey: 3 winners.

BioLegend is ISO 9001:2008 and ISO 13485:2003 Certified

Toll-Free Tel: (US & Canada): 1.877.BIOLEGEND (246.5343) Tel: 858.768.5800 biolegend.com

08-0048-00

4 AAI NewsletterWorld-Class Quality | Superior Customer Support | Outstanding Value April 2015 Focus on Public Affairs

President Obama Releases Budget for FY 2016; The American Association Recommends $1 Billion of Immunologists Increase for NIH 9650 Rockville Pike Bethesda, MD 20814-3994 resident Obama released his nearly Tel: 301-634-7178 P$4 trillion budget for fiscal year (FY) Fax: 301-634-7887 2016 on February 2. The president’s E-mail: [email protected] budget, which alerts Congress to the www.aai.org president’s spending and policy vision Member Services but becomes law only if approved by Tel: 301-634-7195 Congress, would increase discretionary E-mail: [email protected] spending by $75 billion, providing significant relief from the spending caps imposed by sequestration. The budget would also provide a $1 billion increase The Journal (3.3 percent) for the National Institutes of Health (NIH) in FY 2016, boosting the of Immunology NIH budget to $31.3 billion. Tel: 301-634-7197 The president’s budget request for NIH would support 10,303 competing E-mail: [email protected] research project grants (RPGs), an increase of 1,227. The proposal cites four www.jimmunol.org priority areas within the biomedical research portfolio: • Unraveling Life’s Mysteries through Basic Research Council • Translating Discovery into Health President Linda A. Sherman, Ph.D. • Harnessing Data and Technology to Improve Health

Vice President • Preparing a Diverse and Talented Biomedical Research Workforce Dan R. Littman, M.D., Ph.D. Specifically, President Obama would invest $215 million in FY 2016 in a Past President multi-agency, multi-year Precision Medicine Initiative. In the first year, NIH Marc K. Jenkins, Ph.D. would receive $130 million to develop a voluntary national research cohort of at least one million volunteers to “propel our understanding of health and Secretary-Treasurer disease and set the foundation for a new way of doing research through engaged Mitchell Kronenberg, Ph.D. participants and open, responsible data sharing.” In addition, the National Councillors Cancer Institute would receive $70 million “to scale up efforts to identify Arlene H. Sharpe, M.D., Ph.D. genomic drivers in cancer and apply that knowledge in the development of Wayne M. Yokoyama, M.D. more effective approaches to cancer treatment.” An additional $15 million JoAnne L. Flynn, Ph.D. would be allocated to the U.S. Food and Drug Administration (FDA) and Jeremy M. Boss, Ph.D. Department of Health and Human Services’ Office of the National Coordinator Ex Officio Councillors for Health Information Technology for the creation of databases and Pamela J. Fink, Ph.D. development of interoperability standards and requirements (see http://www. Wendy L. Havran, Ph.D. whitehouse.gov/the-press-office/2015/01/30/fact-sheet-president-obama-s- M. Michele Hogan, Ph.D. precision-medicine-initiative). Eugene M. Oltz, Ph.D. Other major NIH investments in the president’s budget include: Executive Director • an increase of $70 million for the president’s Brain Research through M. Michele Hogan, Ph.D. Advancing Innovative Neurotechnologies (BRAIN) Initiative, a program www.aai.org/ intended to revolutionize our understanding of the human brain; About/Departments-Staff • an increase of $100 million to work toward the goals outlined in the Obama administration’s “National Strategy for Combating Antibiotic-Resistant Bacteria”;

www.aai.org AAI Newsletter 5 Focus on Public Affairs (continued)

• an increase of $50 million for Alzheimer’s disease a lower amount of funding for NIH for FY 2016. The bill research; and allows for a 10-percent increase in NIH funding in each of • an increase of $23 million for training, including a the first two years and a roughly six-percent increase in the two-percent increase in trainee stipend rates. four subsequent years. Although the president’s budget is non-binding The Accelerating Biomedical Research Act was first (unless approved by both the House and Senate), it is introduced in the Senate last year by former Senator Tom an important first step in the budget process. Next, the Harkin (D-IA). This year, the Senate version of the bill House and Senate will work toward developing their was introduced by Senator Barbara Mikulski (D-MD), the own budgets, with a goal of producing a joint House- ranking member of the Senate Appropriations Committee, Senate budget resolution by April 15. and is co-sponsored by Senator Ben Cardin (D-MD). AAI has endorsed the Accelerating Biomedical Research Several Congressional Bills Introduced Act. to Bolster NIH Funding American Cures Act Accelerating Biomedical Research Act Senator Richard Durbin (D-IL) re-introduced the American Cures Act, a bill to authorize investment in four agencies and programs that fund biomedical research, including NIH. Last year’s version of the American Cures Act would have Senator created a trust fund for biomedical Richard Durbin research. This year, Durbin is taking Representative Representative Senator Rosa DeLauro Brian Higgins Barbara Mikulski a different approach, much like the one taken in the Accelerating Biomedical Research Act (see above), by creating a budget-cap adjustment. This Representatives Rosa DeLauro (D-CT, 3rd) and adjustment would grant appropriators the authority to Brian Higgins (D-NY, 26th) recently re-introduced exceed the caps on discretionary spending for each of the Accelerating Biomedical Research Act, a bill that the next six years to provide increases for the following would give congressional appropriators the authority agencies and programs: to increase the NIH budget over the next six years, despite existing statutory caps on discretionary • NIH spending. If appropriators took full advantage of this • Centers for Disease Control and Prevention new authority, then they could increase the NIH budget • Department of Defense Health Program, and to approximately $45 billion by FY 2021, more than $15 billion higher than the current NIH budget. • Veterans Medical & Prosthetics Research Program This year’s version of the bill, which has attracted The bill aims to provide sustained and predictable Republican support with Representative Peter King (R-NY, growth for these agencies and programs, which Durbin 2nd) signing on as an original co-sponsor, would create calls “the core drivers of federally funded biomedical a “budget cap adjustment” for the next six years for NIH. research in the U.S.” If appropriators took full Like the previous version, the bill would give congressional advantage of this new budget authority, then the budget appropriators the authority—but not require them—to of each of these agencies and programs included in the exceed the statutory caps on discretionary spending to bill would increase by five percent plus inflation each provide more funding for NIH. For example, in FY 2016, year through FY 2021. the bill provides $3 billion in new budget authority for The American Cures Act is co-sponsored by 10 NIH, enabling appropriators to increase the NIH budget Democratic senators. To date, no House version of the by that amount, even if that increase resulted in Congress legislation has been introduced. exceeding the FY 2016 cap on discretionary spending ($1.016 trillion). But, Congress could also choose not to use AAI has endorsed the American Cures Act for the that increased budget authority and instead, appropriate second consecutive Congress.

6 AAI Newsletter April 2015 Focus on Public Affairs (continued)

Medical Innovation Act “accelerate the discovery, development, and delivery of promising new cures for patients” and help the Senator United States maintain its standing as a global leader Elizabeth Warren in biomedical innovation (see www.energycommerce. (D-MA) and house.gov). The initial discussion draft is the product Representative of an ongoing project known as the 21st Century Cures Chris Van Initiative. Legislators spent over one year gathering data Hollen (D-MD, through various informational sessions and hearings 8th) recently and solicited feedback from both the public and a wide introduced a range of stakeholders. bill that aims to Senator Representative The discussion draft includes the following five topic Elizabeth Warren Chris Van Hollen increase funding areas: “(I) Putting patients first by incorporating their for NIH and FDA. perspectives into the regulatory process and addressing The Medical Innovation Act would require some unmet needs; (II) Building the foundation for 21st pharmaceutical companies that enter into settlement century medicine, including helping young scientists; agreements with the U.S. government to pay a percentage (III) Modernizing clinical trials; (IV) Accelerating of their profits to a fund benefitting NIH and FDA. the discovery, development, and delivery cycle and Companies would be subject to the penalty if they: continuing 21st century innovation at NIH, FDA • were charged by the U.S. Justice Department with [Food and Drug Administration], CDC [Centers for breaking the law and reached a settlement with the Disease Control and Prevention], and CMS [Centers for government; Medicare & Medicaid Services]; and (V) Modernizing medical product regulations.” • sold at least one “blockbuster drug” (a drug that had sales over $1 billion in the previous year) in the previous The discussion draft would require NIH to: calendar year; and • develop a five-year strategic plan, as currently, • sold one or more blockbuster drug(s) that were individual NIH institutes and centers develop “developed, in whole or in part, through Federal strategic plans, but there is no NIH-wide strategic Government investments in medical research.” plan; Companies that meet all of the aforementioned criteria • create a Working Group tasked with reducing the would be required to pay one percent of their net income, administrative burden on scientists, specifically by per blockbuster drug, to the federal government over taking steps to streamline the grant process; and a period of five years. Companies that do not reach a • implement a new program to help support more settlement with the government, but instead take their case young scientists. to trial, would not be subject to this penalty. The discussion draft also would require the The intent of the bill is two pronged: to increase funding Government Accountability Office to complete for NIH and FDA and reverse a trend, described by Warren three studies on NIH: one on “duplication in federal as “a worrisome increase in the number of major drug biomedical research,” another on “waste, fraud, and companies that have been caught breaking the law.” Warren lack of consistency with the NIH mission,” and a third has said that if this policy had been in place over the last five on the NIH Common Fund. years, “NIH would have had nearly $6 billion more every Whereas many of the proposals in the discussion draft year … almost a 20 percent increase in NIH funding” (see are detailed and complete, others remain unfinished. http://www.warren.senate.gov/?p=press_release&id=714). There is a placeholder section for precision medicine, presumably intended to include some or all of President Upton, DeGette Release Obama’s Precision Medicine Initiative (see “President Obama Releases Budget for FY 2016; Recommends Biomedical Research Draft Bill: $1 Billion Increase for NIH” on page 5). There is 21st Century Cures Act also a placeholder section for language regarding Representatives Fred Upton (R-MI, 6th) and Diana government-funded travel for NIH employees. And DeGette (D-CO, 1st), the chair and former ranking whereas the discussion draft proposes to authorize member of the House Energy and Commerce funding for programs, such as the NIH Common Fund Committee, have released a draft bill intended to and the president’s BRAIN Initiative, it does not specify authorization levels for these programs.

www.aai.org AAI Newsletter 7 Focus on Public Affairs (continued)

AAI members are encouraged to share their thoughts are vaccinated. They protect the lives of the vulnerable on the discussion draft with the authors of this draft around them—like infants and those who are ill. Vaccines legislation by sending an email to [email protected]. save lives.”

Congress Holds Hearings on Vaccine- NIH Requests Comment on the Preventable Disease Potential Creation of an Emeritus Award In response to the recent measles outbreak and a surge for Senior Researchers in influenza cases, both NIH recently released a Request for Information (RFI): the House and Senate Sustaining the Biomedical Workforce and a Potential held hearings on the topic Emeritus Award for Senior Researchers. The potential of vaccine-preventable “Emeritus Award” is premised on the notion that there are diseases. At both hearings, senior researchers who may be ready to transition from there was bipartisan a largely research-driven role to a role that focuses on agreement on the efficacy teaching or mentorship but are not wishing to dismantle and value of vaccines their laboratory program completely. The RFI aims to to public health, with Senators Patty Murray gather input on whether the community feels a new and Lamar Alexander legislators on both sides of award is necessary to transition resources and research pictured at the February 10 the aisle urging the public Senate hearing from a more senior investigator to a junior colleague. to take advantage of the Additionally, this RFI seeks comment on what terms and measles and influenza vaccines. timelines might be best for this type of funding. On February 3, 2015, the House Energy and Commerce The idea of a transition grant for senior researchers Subcommittee on Oversight and Investigations held a is not new. In a document released by the Federation of hearing on “Examining the U.S. Public Health Response American Societies for Experimental Biology (FASEB), to Seasonal Influenza.” Committee members heard entitled “Sustaining Discovery in Biological and Medical testimony from Biomedical Advanced Research and Sciences: A Discussion Framework,” it is suggested Development Authority (BARDA) Director Robin that “research sponsors should consider creating a Robinson, Ph.D.; National Center for Immunization and transition award for senior investigators” (http://www. Respiratory Diseases Director Anne Schuchat, M.D.; faseb.org/SustainingDiscovery/Home.aspx). The FASEB National Institute of Allergy and Infectious Diseases recommendation is intended, in part, to make more (NIAID) Director Anthony Fauci, M.D.; and Center for R01s available for young and mid-level investigators Biologics Evaluation and Research (CDER) Director Karen by facilitating a reduced research program for those Midthun, M.D. Whereas the hearing focused on the causes investigators who are ready to move on to other roles. of the relative inefficacy of this season’s influenza vaccine, This award would provide time and funding to transfer members frequently asked about the measles outbreak. projects and ensure that graduate students are able to The witnesses repeatedly affirmed the safety of vaccines, complete their studies before lab closure. with Fauci emphasizing that the measles vaccine is “one of the most highly effective vaccines against any virus.” Additional details about the proposed Emeritus Award were presented by NIH Deputy Director for Extramural On February 10, 2015, the Senate Health, Education, Research Sally Rockey, Ph.D., in her Rock Talk blog. To Labor and Pensions Committee held a hearing on “The date, the community comments on this blog post have Reemergence of Vaccine-Preventable Diseases: Exploring been largely negative, reflecting widespread concerns the Public Health Successes and Challenges.” The that the creation of a new award would detract from witnesses (Dr. Schuchat; parent and pediatrician Tim Jacks, R01 funding. In addition, many have argued that there D.O.; Tennessee Department of Health Immunization are already mechanisms in place to transition grants to Program Director Kelly Moore, M.D., M.P.H.; and University other researchers and that researchers have the option to of California, San Diego, Professor of Clinical Pediatrics include co-principal investigators on grants, rendering an Mark Sawyer, M.D.) stressed the importance of vaccination Emeritus Award redundant. and described strategies used to increase vaccination rates. During the hearing, Committee Chair Lamar Alexander AAI responded to the RFI on March 6; view the AAI (R-TN) summed up the emphatic view of the bipartisan comments at www.aai.org/Public_Affairs/Letters- group of members present, stating: “Sound science is this: Comments.html. vaccines save lives. They save the lives of the people who

8 AAI Newsletter April 2015 gene targets that modulate inflammation and influence Investigators Embark on New autoimmune disease severity and cancer pathogenesis and suspected that these genes should be amenable to Research Frontiers with the AAI siRNA-based therapeutics. However, my lab didn’t have Travel for Techniques Program the capability to generate nanoparticles of the optimum composition to deliver siRNA in vivo,” says Allen. “Because of the Travel for Techniques Program, I was able to visit another institution to observe the nanoparticle fabrication process, allowing for a deeper understanding of the methods and applications for this technique. I can now apply this technique to the fabrication of siRNA therapeutics for use in my studies.” Another program participant, Pooja Jain (AAI ’09), was able to team up with investigators in her host PI’s lab to generate data she hopes to translate into a manuscript. “As a result of my teamwork with Jerry Boss’ (AAI ’94) lab, we were able to successfully create RRBS libraries from DNA samples derived from immune cells. The data generated on this visit will help in the preparation of a manuscript and submission of a joint grant proposal.” AAI Travel for Techniques Program awardee Pooja Jain (third Program participants attest to the benefits of the award from right) taking a break from learning new protocols with her beyond becoming proficient in a laboratory technique, host PI’s lab members noting that the experience offers them access to technical training from researchers proficient in the desired field of expertise, opportunities for future collaboration, and n 2014, AAI successfully launched the Travel for insightful perspectives from host institution investigators ITechniques Program, adding an additional funding about the traveling PI’s research. opportunity to its already robust support for scientists through fellowships, career awards, and travel grants. This “This program has provided me with many benefits,” award is given to member principal investigators (PIs), remarked Holly Algood (AAI ’11), a 2014 fall cycle awardee reimbursing up to $1,500 in expenses for travel to another who traveled from Vanderbilt University to the University of institution to learn a technique beneficial to the PI's Cincinnati to gain expertise in gastric ulceration models. “In research. the short term, I have learned a new technique applicable to my research and obtained preliminary data for a grant I am The 12 investigators awarded funds so far through the Travel planning to submit to NIH. I am also hopeful that this trip for Techniques Program have set out on journeys crisscrossing will lead to a long-term collaboration mutually beneficial the country to expand their repertoire of techniques and to my lab and that of my host PI, who, as a physiologist, help meet the demands of new research initiatives in their provides a unique viewpoint on my research.” labs. Some awardees have sought expertise that seemed, at first mention, to be well beyond the familiar realm of Jyotika Sharma (AAI ’05), another fall cycle awardee, immunology research. Participants have been trained in indicated that the program was particularly useful for young techniques ranging from reduced representation bisulfite faculty, saying, “This program provides a unique platform sequencing (RRBS), a high-throughput technique used to to initiate interactions and collaborative opportunities analyze a representative sample of genome-wide methylation with scientists at other institutions in an informal and profiles at the single nucleotide level, for use in studying comfortable setting. This is especially beneficial for young the stages of dendritic cell differentiation, to immuno-spin investigators, like me, who have recently started their own trapping for the detection of DNA free radicals in murine research labs.” diabetes models. Some awardees have traveled to learn more The Travel for Techniques Program considers proposals on conventional immunological techniques unavailable at their a rolling basis with application deadlines in February, June, own institutions, such as the culture of primary human CD4+ and October. The spring application cycle for the program T cells. will open on April 15th and close on June 15th. For more Technical expertise acquired through the Travel for information regarding eligibility requirements, to see the Techniques Program has helped participants resolve list of previous recipients, or to download the application, myriad research problems and goals. Irving Allen (AAI please visit the Travel for Techniques webpage at ’12), a 2014 summer cycle awardee from the Virginia www.aai.org/Careers/TfT.html. Inquiries about the program Polytechnic Institute, traveled to the University of North may be directed to [email protected]. Be sure to stop by the AAI ™ Carolina, Chapel Hill, to learn how to fabricate solid core booth (#901) at IMMUNOLOGY 2015 to learn more about polyethylene glycol nanoparticles for use in delivery the AAI grants and awards programs. of small molecule treatments in vivo. “We’d identified

www.aai.org AAI Newsletter 9 The Jackson Laboratory Humanized NSGTM Mice

Sophisticated. Innovative. Versatile.

JAX humanized NSGTM is the platform of choice for studying hematopoiesis, inflammatory disease, viral host-pathogen interactions, or working to accelerate the development of novel therapies in HIV infection and oncology. Learn more, visit JAX at Immunology 2015, booth #1001

jaxmice.jax.org 1-800-422-6423 2015 AAI Career Award Recipients AAI proudly presents the 2015 AAI Awards for outstanding research and career achievements.

Jonathan Sprent California, holding the appointment of professor at Scripps and adjunct professor at the University of California, San Diego. In Honored with AAI 2006, he returned to Australia to the Garvan Institute of Medical Research, where he currently serves as professor and head of Lifetime Achievement the Cellular Immunity Laboratory. He also holds the positions of Award adjunct professor at Scripps, conjoint professor at the University of New South Wales in Sydney, and professor at Pohang University Jonathan Sprent, M.B.B.S., Ph.D., of Science and Technology in South Korea. Garvan Institute of Medical Research, Dr. Sprent has received many accolades for his contributions is the recipient of the 2015 AAI to the field. He is a fellow of the Royal Society, a fellow of the Lifetime Achievement Award in Australian Academy of Science, and an honorary member of the recognition of a career of extraordinary British Society for Immunology. He has received the Excellence scientific achievement coupled with exceptional leadership and Award and the Burnet Award from the Australian National service to AAI. This award is the highest honor bestowed by the Health and Medical Research Council, two Merit Awards from AAI Council upon an AAI member. the NIH, and the J. Allyn Taylor International Prize in Medicine Sprent has been a career-long world leader in the area from the Robarts Research Institute. From among his hundreds of T cell biology. Among his early, seminal findings, was his of highly cited papers, his early paper on the recruitment of demonstration in 1971 that alloantigen-activated T cells were antigen-activated T cells has been re-published in The Journal selectively recruited from the circulation. Other ground- of Immunology “Pillars of Immunology” section reserved for breaking early experiments by Sprent showed two distinct papers deemed “classics in the field.” He is also a frequently subgroups of T helper cells in F1 hybrid mice, each able to help invited speaker at scientific meetings and lectures in Australia B cells from one parental strain, and the negative selection and abroad, delivering the Burnet Oration at the Australasian of T cells by filtration through an allogeneic host. These early Society for Immunology annual meeting, the Russell S. and Rae discoveries laid the foundation for our understanding of Weiser Endowed Lecture at the University of Washington, and the lymphocyte homing and MHC restriction. Sprent has sustained Director’s Lecture at the Walter and Eliza Hall Institute, among his exploration of many cutting-edge aspects of T cell biology, others. including the role of T cell subsets in graft-versus-host disease, For his career-long, ground-breaking scientific contributions mechanisms of positive and negative selection during T and service to the field of immunology, it is most fitting that Dr. cell differentiation, and factors that promote the survival of Sprent be honored with the AAI Lifetime Achievement Award. memory T cells. Recent work by his laboratory has also focused on the development of immunotherapies for treatment of The AAI Lifetime Achievement Award is given annually in autoimmunity, transplant rejection, and cancer. recognition of distinguished scientific accomplishment and extraordinary service to AAI. An AAI member since 1980, Sprent was elected to AAI Council in 1993 and served as AAI president from 1998 to 1999. He has also served as a member of the AAI Publications Committee, as a Distinguished Lecturer and Major Symposium AAI Excellence speaker at the AAI annual meeting, an associate editor for The JI, in Mentoring Award a delegate to the International Union of Immunological Societies (IUIS), and a representative to the IUIS Council. Bestowed upon Sprent’s commitment to the scientific community is further Rafi Ahmed evident from his service on scientific advisory boards for the Howard Hughes Medical Institute, Kimmel Cancer Center, and Rafi Ahmed, Ph.D., Emory University Edward Jenner Institute for Vaccine Research. He has also served School of Medicine, is the recipient on the National Institutes of Health (NIH) Immunobiology Study of the 2015 AAI Excellence in Section and the editorial boards of numerous scientific journals. Mentoring Award in recognition of his Sprent received his M.B.B.S. from the University of contributions to a future generation of Queensland before obtaining his Ph.D. from the Walter and scientists. Eliza Hall Institute in 1972. Following research positions at the Dr. Ahmed is renowned as a researcher for his work Basel Institute for Immunology in Switzerland and University contributing to understanding immunologic memory of T and College in the United Kingdom, he became a faculty member at B cells and the immunobiology of virus infection. Ahmed’s the University of Pennsylvania School of Medicine in 1976 and contributions include the discovery that T cell memory could be rose in the ranks to a full professor by the time of his departure long lived and persist in the absence of antigen; the demonstration in 1983. He moved to The Scripps Research Institute in La Jolla, of T cell exhaustion in chronic viral infection; and the identification

www.aai.org AAI Newsletter 11 of the role of inhibitory receptor programmed death 1 (PD-1) he helps find a solution, often with some humor to lighten the in T cell exhaustion. His work has led to the development of situation. His ability to remain positive is a torch that I try to new vaccines and the development of PD-1 blockade therapy, carry with me, and when my students and postdocs enter my which is showing promise for the treatment of chronic infections office to tell me of a failed experiment or something else that is and cancer. Dr. Ahmed was recently elected to the Institute of causing grief and stress, I try to remind myself of how Rafi would Medicine of the National Academy of Sciences in honor of his handle this situation…with a smile and some reassurance.” scientific achievements. Ahmed obtained his Ph.D. from Harvard University in His other legacy is the remarkable number of successful 1981. Following a research fellowship at the Scripps Clinic and scientists—more than 75—he has mentored throughout Research Foundation in La Jolla, California, he became a faculty his career. Impressively, more than one-third of his former member at the UCLA School of Medicine, holding the rank trainees hold faculty positions and have established their own of full professor at his departure in 1995. He moved to Emory laboratories at universities and research institutions in the University, where he currently serves as Charles Howard Candler United States and abroad, including the University of California, Professor of Microbiology and Immunology, director of the University of North Carolina, La Jolla Institute for Allergy Emory Vaccine Center, and Georgia Research Alliance Eminent and Immunology, University of Pennsylvania, Yale Medical Scholar in Vaccine Research. School, University of Minnesota, National Taiwan University, Dr. Ahmed is a member of the National Academy of Sciences and University of Melbourne. Others have achieved success and a fellow of the American Association for the Advancement of at scientific corporations, U.S. government organizations, Science. He is a frequent invited speaker, presenting his research scientific foundations, clinics, and law firms. Many of Ahmed’s in a Distinguished Lecture at the AAI annual meeting, the Dan trainees have continued to make important contributions in H. Campbell Memorial Lecture at the Midwinter Conference of immunology, particularly in the areas of immunologic memory, Immunologists, the Janeway Lecture at Yale University, a National infectious disease, and vaccine therapy. Institutes of Health Director’s Lecture, and the Baruj Benacerraf His past trainees attribute their own success to abilities that Lecture in Immunology at Harvard University, among others. Ahmed honed in them: skills in writing scientific manuscripts, He has been honored by Emory University with the Dean’s giving clear presentations, and reviewing papers. He also Distinguished Faculty Lecture and Award and the Albert E. Levy directly mentors his trainees in every aspect of grant writing, Scientific Research Award. He also has served on numerous from planning of the budgets and administrative sections to the scientific advisory and journal editorial boards. writing of the specific aims section and generation of figures. A member of AAI since 1984, Ahmed has served on the AAI Many who served in his lab have received their first R01 within Nominating Committee and as a faculty member for the AAI the first year of starting their own labs. Advanced Course. Ahmed is said to exemplify many qualities essential to The AAI Excellence in Mentoring Award is presented annually outstanding science and research. One former postdoctoral in recognition of exemplary career contributions to a future fellow, E. John Wherry, director of the Institute for Immunology generation of scientists. at the University of Pennsylvania Perelman School of Medicine, explains how Ahmed instills in his trainees an expectation for precision and excellence: “For Rafi, it is always much more important to be absolutely, positively correct than to be finished Mary Ellen Conley with a grant, paper, or experiment. Better not to submit if it Presented with the wasn’t perfect. In his lab, this often led to sleepless nights before deadlines, dozens upon dozens of ‘final’ drafts of papers, and AAI-Steinman Award hundreds of reanalyzed experiments. However, the result was always the best possible grant, paper, or presentation.” for Human Immunology Ahmed is also widely praised for his robust support of Research collaboration both inside and outside of his laboratory. He invariably meets with trainees whose projects he sees are starting Mary Ellen Conley, M.D., Rockefeller to overlap, often turning potentially competitive projects into University, is the recipient of the opportunities for collaboration. He purposely seeks the opinions 2015 AAI-Steinman Award for Human Immunology Research. of his trainees, promoting their confidence in their scientific Conley is recognized for her outstanding contributions to acumen. His former trainees note how open and generous the understanding of primary immunodeficiencies (PIDs), Ahmed is with his time even once they have left his lab. He is particulary B cell PIDs, and her prowess as a clinical investigator highly proactive in recommending both current and past fellows and diagnostician in the field of pediatric immunology. for faculty positions and speaking engagements, enthusiastically Conley, along with Owen Witte, was instrumental in the promoting their accomplishments to his peers when visiting genetic characterization of the first known PID, X-linked other institutions or chatting with colleagues. His trainees know agammaglobulinemia (XLA), describing several mutations he remains available to offer career or research advice—or just to in the gene encoding Bruton’s tyrosine kinase (BTK). After chat about what’s new in the field. this first foray into the study of PIDs, Conley devoted the His relentlessly positive attitude is regarded as a great next 20 years to investigating the genetic and immunological motivator. Former postdoctoral fellow, Susan Kaech, associate foundation of several autosomal recessive and dominant forms professor at the Yale School of Medicine, says, “Rafi always greets of agammaglobulinemia. Her lab revealed that mutations in the you with a smile and a chuckle, and even at the bleakest of times, μ heavy chain gene caused a clinical disorder similar to XLA, and

12 AAI Newsletter April 2015 also pioneered research into agammaglobulinemias caused by AAI-Thermo Fisher mutations in BLNK, PIK3R1 , and TCF3. Her work deciphering PIDs in clinical patients bridged the Meritorious Career divide between the bedside and bench, yielding key insights Award Conferred upon into basic human B cell development and signaling pathways. Conley’s examination of human B cells with mutations in BTK Ronald N. Germain and the μ heavy chain gene showed that B cell differentiation stagnated at the same point in these cells, providing evidence to Ronald N. Germain, M.D., Ph.D., support the hypothesis that BTK was an important component of National Institutes of Health (NIH), the B cell signaling complex. Conley’s studies also revealed that National Institute of Allergy and B cell receptor signaling requires a protein scaffold, and some μ Infectious Diseases (NIAID), Laboratory heavy chains are expressed on the B cell surface, which laid the of Systems Biology, is honored with the groundwork for further studies by others into the process of B cell 2015 AAI-Thermo Fisher Meritorious Career Award. Germain is negative selection. Her work is also lauded for its juxtaposition of recognized for his outstanding research contributions to T cell the human and mouse, shedding light on the differences in B cell antigen recognition and pioneering work in systems biology and development and differentiation between these two organisms. the real-time imaging of immune responses. Beyond her role as an investigator, Conley’s colleagues In his early work, Germain made seminal contributions recognize her as an exemplary physician-scientist who is able to understanding the complexities of antigen recognition. to balance scientific discovery with the empathy required for Germain made key findings that advanced understanding of the quality patient care. “I am most grateful personally to Mary relationship between the structure of major histocompatibility Ellen for what she taught me about compassion and the care complex (MHC) class II and its function, the molecular basis of the ill,” says Nobel laureate Peter Doherty, Michael F. Tamer of T cell antigen recognition, and the mechanism of antigen Chair of Biomedical Research at St. Jude Children’s Research processing. He has also provided insight into how T cell selection Hospital, and professor laureate at the University of Melbourne. in the thymus deters the development of an autoreactive T cell Doherty thanks the “Mary Ellen Conley voice” in his head for repertoire. helping him address clinical and ethical issues in public forums Now, more than ever before, Germain’s work focuses on more empathetically. “Through Conley’s example, I came to understanding the anatomy of the immune response, using in understand more fully what it means to have a very sick child vivo imaging, systems biology approaches, and more traditional with a genetically determined syndrome and how it is that people techniques, to examine immunity to foreign pathogens at the cope with such an immense emotional and practical challenge.” cell, tissue, and organismal level. Germain was one of the first Conley received her M.D. from the University of California, immunologists to investigate basic immune functions in real San Diego, in 1975. Following a pediatric residency at the time, helping to develop dynamic in vivo imaging techniques to Children’s Orthopedic Hospital in Seattle, Washington, Conley analyze cell trafficking and distribution within lymphoid organs served as a postdoctoral fellow at the University of Alabama, under steady-state and antigenic challenge conditions. His work Birmingham. In 1980, she joined the faculty of the University with this technique has branched off into many other avenues of Pennsylvania as an assistant professor, rising to the rank of of immune investigation, including the identification of the associate professor before her departure in 1988 to take positions underlying defect in B cell-helper T cell interactions that causes as the Federal Express Professor of Pediatrics at the University of immunoglobulin deficiency in X-linked proliferative disease. Tennessee and as a member of the Department of Immunology Combining these techniques with systems biology approaches at St. Jude Children’s Research Hospital. In 2014, Conley moved to in the Laboratory of Systems Biology at NIH, which he helped the Rockefeller University, where she currently holds the position found, Germain queries ever broader concepts that target the of professor. fundamental understanding of immunity. Dr. Conley is the recipient of a National Institutes of Health Germain’s colleagues testify to his lifelong passion for and MERIT Award, the Immune Deficiency Foundation Lifetime leadership in the field of immunology, pointing out that, after Achievement Award, and the Thomas Waldmann Award for more than 40 years in the field, Germain has entered one of Excellence in Human Immunology. She has also been nominated the most prolific phases of his career. William Paul, chief of the as a Best Doctor in America (bestdoctors.com) on multiple Laboratory of Immunology at NIAID, says, “Indeed, the last five occasions and serves as a member of the International Union years, are, in my view, the most productive and exciting of Ron’s of Immunological Societies’ Primary Immunodeficiency Expert entire career and I would predict that the next five years will Committee. be even more productive. Our colleagues in the immunology community throughout the world regard Ron’s newest series Conley has been an AAI member since 1982 and has served of studies as having a virtually revolutionary impact on our the association as an AAI Clinical Immunology Committee understanding of how the immune system functions in real time.” member, Abstract Programming Chair, and faculty member at the AAI Introductory Course in Immunology. In 1976, Germain received both his M.D. and Ph.D. degrees from Harvard University. He was appointed an assistant The AAI-Steinman Award for Human Immunology Research professor of pathology at the Harvard Medical School in 1977, is presented annually for significant, sustained achievement in where he subsequently rose to the rank of associate professor in immunology research pertinent to human disease pathogenesis, 1980. From there, he moved to the NIH, where he has held several prevention, or therapy. appointments, including the deputy chief of the Laboratory of Immunology and the director of the Program in Systems

www.aai.org AAI Newsletter 13 Immunology and Infectious Disease Modeling. He is currently Kanneganti then described its role in protecting epithelial the chief of the Laboratory of Systems Biology at NIAID and the integrity in experimental autoimmune colitis. She also associate director for Systems Biology and Technology at the explored the function of other inflammasome components, Trans-NIH Center for Human Immunology, Autoimmunity, and showing that NLRP12 attenuated colon inflammation Inflammation. and tumorigenesis, and that NLRP6 negatively regulated Dr. Germain is an elected member of the Institute of inflammation by downmodulating NFțB responses. She has Medicine of the National Academy of Sciences. He is also an further contributed toward elucidating the mechanisms of IL-1- American Association for the Advancement of Science fellow mediated disease, with her demonstration that IL-1Į produced and an associate member of the European Molecular Biology independently of inflammasomes induced autoinflammation, Organization, in addition to holding several other elected and and that diet-induced changes in the microbiota modulated honorary memberships in scientific organizations. Germain has IL-1ȕ-dependent inflammatory bone disease in a mouse model been honored with several NIH distinctions, including the NIH of osteomyelitis. Director’s Merit Award, the NIAID Merit Award, and a designation Nobel laureate Peter Doherty, the Michael F. Tamer Chair of as an NIH Distinguished Investigator. He has also received the Biomedical Research at St. Jude Children’s Research Hospital, Meritorious Presidential Rank Award from the United States and professor laureate at the University of Melbourne, credits government and the Landsteiner Medal from the Austrian Society Kanneganti’s broad undergraduate training in zoology, botany, of Allergology and Immunology. and chemistry as one of her strengths: “The consequence of In addition to his other distinctions, Germain has received this is that, while a very focused researcher, Thirumala has a numerous lectureship honors from around the world. He has also very broad-spectrum view of biology and of the significance of served on myriad conference, symposia, and review committees, what we do as scientists. Perhaps this depth of experience has including the Howard Hughes Medical Institute (HHMI) also contributed to her incredible capacity to take an initial, Scientific Review Board and the HHMI-NIH Research Scholars intriguing finding through to a well-developed comprehensive Program Advisory Committee. research publication over a relatively short time.” Dr. Germain has been a member of AAI since 1978. He has Kanneganti earned her Ph.D. from Osmania University spoken at the AAI annual meeting on numerous occasions, in India in 2001. Following postdoctoral fellowships at Ohio lecturing as a Major Symposium speaker, Distinguished Lecturer, State University and the University of Michigan, she assumed and as a member of the President’s Symposium. He has served as a research investigator position at the University of Michigan. an associate and deputy editor for The Journal of Immunology, as In 2007, she joined the Department of Immunology at St. Jude a member of the AAI Membership, Education, and Nomination Children’s Research Hospital and moved through the ranks Committees, and as a course faculty member for the AAI rapidly to her current position of member. Introductory Course in Immunology. Kanneganti has shown tremendous productivity, authoring The AAI-Thermo Fisher Meritorious Career Award is given over 128 publications and regularly publishing her findings annually for outstanding research contributions to the field of in prestigious journals such as Nature, Nature Immunology, Immunity, and The Journal of Immunology (The JI). She is immunology. frequently invited to speak at international meetings, including plenary lectures at the annual meeting of the German Society for Hygiene and Microbiology and German Society for Infectiology; Thirumala-Devi and Lorne Infection and Immunity Conference. She has served on numerous study sections and special emphasis panels Kanneganti Receives for the National Institutes of Health, as well as international the AAI-BD Biosciences review boards, including the United Kingdom Medical Research Council, Netherlands Organization of Scientific Research, Investigator Award European Research Council, Israel Science Foundation, and Singapore National Medical Research Council. She has also Thirumala-Devi Kanneganti, Ph.D., served at St. Jude as a member of its Institutional Biosafety St. Jude Children’s Research Hospital, Committee, Institutional Animal Care and Use Committee, has been chosen to receive the 2015 Signal Transduction Program, and as a session chair and on AAI-BD Biosciences Investigator the student evaluation committee for the St. Jude Graduate Award. She receives the award National Symposium. Paul Thomas, Associate Member, St. Jude for her fundamental contributions to our understanding Children’s Research Hospital, says, “In our own department at of inflammasome biology and IL-1 regulation. She first St. Jude, Dr. Kanneganti is a mentor and leader for the junior broke ground as a postdoctoral fellow in the laboratory of faculty, providing generous amounts of her time and resources Gabriel Núñez at the University of Michigan Medical School, to support other investigators.” where she found that bacterial DNA engaged the NLRP3 inflammasome for the production of IL-1ȕ. Since setting up An AAI member since 2006, Kanneganti currently is a section her own laboratory at St. Jude Children’s Research Hospital, editor for The JI. She has also been a Major Symposium speaker she has continued to make seminal discoveries. She extended at the AAI annual meeting. her earlier findings to show that the NLRP3 inflammasome The AAI-BD Biosciences Investigator Award is presented also mediated a healing response to influenza infection. annually for outstanding, early-career research contributions Having established the critical role of NLRP3 during infection, to the field of immunology.

14 AAI Newsletter April 2015 2015 AAI Distinguished An AAI member since 1989, Kovacs previously served as a member of the AAI Minority Affairs Committee (2000-2003) Service Award and as a faculty member for the 2014 AAI Advanced Course in Presented to Immunology. Kovacs earned her Ph.D. from the University of Vermont Elizabeth J. Kovacs in 1984. Following a postdoctoral fellowship at the National Cancer Institute, she joined the faculty of Loyola University Elizabeth J. Kovacs, Ph.D., Loyola Chicago, where she now serves as professor in the Departments University Chicago Stritch School of of Surgery and of Microbiology and Immunology, director of the Medicine, is being honored with the Alcohol Research Program, director of Research at the Burn and 2015 AAI Distinguished Service Award. Shock Trauma Research Institute, and vice chair of Research in She provided invaluable service to AAI the Department of Surgery. during her tenure on the AAI Committee on Public Affairs (CPA) from 2007 to 2014, serving the last two years as chair. The AAI Distinguished Service Award is presented for outstanding service to the AAI community and the immunology During her tenure, Kovacs provided vital leadership and field as a whole. support to two key public policy advocacy programs created by the CPA: the AAI Public Policy Fellows Program, which provides postdoctoral fellows and other junior scientists with the opportunity to learn about and participate in the public policy and legislative activities of AAI; and the AAI Research Advocacy The Inaugural Program, which enables policy leaders from relevant patient AAI-BioLegend advocacy organizations to learn about basic immunology and about public policy issues of concern to AAI. Her involvement Herzenberg Award with both programs ran deep; she helped select and oversee the first four classes of AAI Public Policy Fellows, participated in Is Bestowed upon multiple Capitol Hill visits with the Fellows to help convey our Matthew D. Scharff advocacy message, and otherwise helped make the program a valuable experience for our AAI-member participants. Kovacs Matthew D. Scharff, M.D., Albert also served for several years as a speaker for the AAI Research Einstein College of Medicine, is the Advocacy Program, helping non-scientist leaders of patient recipient of the first AAI-BioLegend advocacy organizations better understand how the immune Herzenberg Award. This award is given in recognition of system impacts the diseases to which their organizations his pioneering work in the development of the monoclonal are devoted and why supporting immunological research is antibody technique and antibody synthesis, as well as his essential to their goals. studies on the development of antibody diversity. Kovacs also helped develop and participate in educational Scharff pioneered early studies fundamental to the sessions sponsored by the CPA at AAI annual meetings. She understanding of the biochemistry of antibody synthesis. He shared her expertise on peer review issues as a speaker at the engineered antibody-producing myeloma cell lines to study the 2012 CPA session: “NIH Peer Review: Understanding the New production and assembly of immunoglobulin heavy and light System.” In 2013 and 2014, she chaired the sessions: “The chains, demonstrating both how immunoglobulin polypeptide Importance of Communicating Science in an Era of Doubters chains are synthesized on polyribosomes and how the chains and Deniers” and “Rock-Talking With Sally Rockey: The subsequently coalesce to form mature immunoglobulin Issues, the Blog, and the Woman Behind It All.” In addition, molecules. This work laid the foundation for Scharff’s later at IMMUNOLOGY 2014TM, she oversaw the 25th anniversary contributions to the development of methodologies for celebration of the AAI Public Affairs Program, which included the generation of monoclonal antibodies, a technique that a reception and show featuring the political satire group, The revolutionized the field of immunology. Capitol Steps. Scharff has also made seminal contributions to the As committee chair, Kovacs submitted congressional testimony mechanistic elucidation of immunoglobulin class-switch on behalf of AAI to the House and Senate Appropriations recombination and somatic hypermutation. His lab Subcommittees on Labor, Health and Human Services, Education, demonstrated that activation-induced cytidine deaminase and Related Agencies, which fund NIH. In her testimony and (AID) was the sole B cell-specific molecule required for somatic in numerous visits to members of Congress, Kovacs advocated mutation by expressing this enzyme in non-B cells to induce for increased and predictable NIH funding, explained the this event. His proposal that AID functions by deaminating importance and promise of immunological research, and deoxycytidine in DNA and recruiting translesional polymerases espoused the economic, national, and local benefits of investing in that could potentially introduce mutations into the code was biomedical research. She also participated in the selection of, and later confirmed by both his own studies and those of Michael presentation to, three AAI Public Service Awardees: Representative S. Neuberger and others. Scharff, along with Betty Diamond, Chris Van Hollen in 2012, Representative Rosa DeLauro in 2013, then a postdoctoral fellow in his lab, additionally showed that and Senator Richard Durbin in 2014. Kovacs also brought AAI these somatic mutations arising in B cells during the course concerns to the attention of NIH officials and other leaders in the of an immune response to foreign antigen could introduce biomedical research community, ensuring that immunologists’ autoreactive antibodies into the B cell repertoire, revealing voices were heard in the major debates affecting our members’ professional lives. www.aai.org AAI Newsletter 15 paradigm-shifting evidence for how autoantibodies arise in in the Department of Cell Biology at Albert Einstein College of the body. Along with these studies, Scharff has demonstrated Medicine in 1964, he was an intern and assistant resident at the that antibodies of differing isotypes but bearing identical Boston City Hospital (1959–1961) and a research associate at the variable regions can vary wildly in their immune effects, either National Institute of Allergy and Infectious Diseases (1961– exacerbating or protecting against disease. 1963). He has held various professorial, chairman, and director In addition to his scientific contributions to B cell biology, roles at Albert Einstein College of Medicine over the course of over the span of his career, Scharff has innovated technologies his 50-year tenure and has held the position of Distinguished and methodologies that have immensely benefited the field of Professor since 2006. immunology. His work with polyethylene glycol demonstrated Dr. Scharff is a member of the National Academy of that this substance was able to increase the frequency of fusion Sciences, the American Academy of Arts and Sciences, and in plasma cells. He also developed monoclonal antibody the Phi Beta Kappa Society. Among other honors, Scharff has generation techniques that are still used by academic and received Outstanding Investigator Awards from the National industry scientists to generate antibodies with predetermined Cancer Institute, the New York Academy of Medicine Medal, the specificities, a technique instrumental to the development of Lifetime Achievement Award for Outstanding Teaching from therapeutic antibodies now used in the clinic. the Albert Einstein College of Medicine, and the Mayor of New Colleagues laud Scharff’s scientific and directorial York’s Lifetime Achievement Award for Excellence in Science capabilities, seeking his counsel for matters ranging from and Technology. He was also invited to give a prestigious Harvey research projects to scientific policy. Arturo Casadevall, Lecture on his groundbreaking studies in the biochemistry of professor and chair of the Department of Microbiology and antibody synthesis. Immunology, Albert Einstein College of Medicine, says, “Dr. Scharff has been a member of AAI since 1964 and has Scharff has a reputation that is unparalleled in the scientific served AAI as a member of the Committee on Public Affairs. In community. His counsel is sought for his scientific acumen and recognition of the number of successful scientists who have his wisdom in developing scientific programs and policy for trained in his laboratory, Dr. Scharff was presented the AAI the scientific community. He is truly an elder statesman of the Excellence in Mentoring Award in 1998. immunologic and scientific enterprise.” The AAI-BioLegend Herzenberg Award was established in 2014 Scharff earned his M.D. from the New York University to honor the memory of Leonard A. Herzenberg. This award is College of Medicine in 1959, graduating with honors in presented annually for outstanding contributions to the field of microbiology. Before attaining his first assistant professorship immunology in the area of B cell biology.

IMMUNOLOGY 2015 ™ THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS MAY 8-12, 2015 | AAI ANNUAL MEETING | NEW ORLEANS, LA

MARK YOUR CALENDAR!

REGISTRATION HOUSING Registration Now OPEN! Housing Reservations Now OPEN! Join AAI to Qualify for Discounted Rates Discounted Hotel Rate Closes April 9, 2015 www.IMMUNOLOGY2015.org/registration www.IMMUNOLOGY2015.org/housing

16 AAI Newsletter April 2015 Join us for the IMMUNO LOGY 2015™ Opening Night Welcome Reception

Generously Sponsored by eBioscience, an Affymetrix business

Great Hall Lobby – Ernest N. Morial Convention Center • Friday, May 8, 2015 • 6:00 PM – 8:00 PM

At the close of the President’s Address, follow the parade into the Great Hall Lobby to sample the many flavors of New Orleans cuisine, catch up with old friends, mingle with revelers “borrowed” from Mardi Gras—and try the Cajun two-step to the celebrated Dwayne Dopsie & Zydeco Hellraisers band.

Open to all IMMUNOLOGY 2015™ attendees. Meeting badge required for entry. Attendees must be at least 21 years of age. www.aai.org AAI Newsletter 17 Members in the News John Kappler, Philippa Marrack, examining the prevention of self-reactivity, they showed that thymocytes tolerate self-MHC by undergoing clonal Jeffrey Ravetch Share 2015 Wolf deletion in the thymus rather than via suppressive Prize in Medicine Honors mechanisms. The lab’s recent efforts in structural biology continue to identify motifs and conformations that AAI members John Kappler (AAI ’74), Philippa Marrack delineate TCR binding to MHC molecules. Other joint (AAI ’74), and Jeffrey Ravetch (AAI ’99) have been projects investigate the intricacies of TCR interactions named co-recipients of the 2015 Wolf Prize in Medicine with peptide:MHC complexes, using high-throughput for their work on the molecular basis of the immune methodologies to identify peptide:MHC combinations response. Awarded by Israel’s Wolf Foundation, the Wolf that are recognized by self-reactive T cells in autoimmune Prize in Medicine confers a monetary award of $100,000 diseases, such as diabetes, rheumatoid arthritis, and which will be shared this year by the co-recipients. allergic reactions to the metals nickel and beryllium. The Since 1978, the foundation has awarded prizes in the lab group’s autoimmunity studies also encompass an arts and sciences that are presented annually by the investigation of gender bias in the development of some Israel president. The five prizes being awarded in 2015 autoimmune diseases, recently identifying a subset of recognize seven scientists and two musicians, who will autoreactive B cells that is expanded in aged female mice be honored at a May award ceremony in Tel Aviv. and is more prevalent in female humans with autoimmune disease. Dr. Kappler’s investigations, together with Dr. John W. Kappler, Ph.D., Marrack’s, continue to interrogate the basic operations of AAI ’74, Investigator, the immune system in the hopes of using this knowledge Howard Hughes Medical to develop therapies and vaccines useful for combating Institute; Distinguished human disease. Professor, Integrated A past AAI Distinguished Lecturer, Kappler has served as Department of an associate editor for The Journal of Immunology and Immunology, National was co-recipient, along with Marrack, of the 1995 AAI Jewish Health, and Behring-Heidelberger Award. Their additional shared Professor of Pharmacology, honors include the Royal Society’s Wellcome Foundation University of Colorado Prize, The Paul Ehrlich and Ludwig Darmstadter Prize (Paul Health Sciences Center Ehrlich Foundation); and the Louisa Gross Horwitz Prize John Kappler, in (Columbia University). John Kappler collaboration with Kappler is a member of the National Academy of Sciences Philippa Marrack, and the Institute of Medicine and a fellow of the American with whom he shares Association for the Advancement of Science. His additional a lab group, focuses on unraveling the intricacies of career honors include the Bonfils-Stanton Foundation T cell development, function, and structure, with an Award in Science and Medicine; Cancer Research Institute’s emphasis on studying the interaction between the T William B. Coley Award; National Jewish Medical and cell receptor (TCR) and foreign/self-peptide bound to a Research Center Lifetime Achievement Award; National major histocompatibility complex (MHC). The Kappler- Jewish Health Outstanding Scientific Achievement in Marrack lab was instrumental to determining that T cells Basic Research Award; Abraham J. Kauvar Presidential simultaneously recognize foreign peptide together with Award; Graduate School Dean’s Mentoring Award, an MHC molecule. Along with others, they identified University of Colorado Health Sciences Center; Ernst W. the TCR, a finding that revolutionized the T cell biology Bertner Memorial Award, MD Anderson Cancer Center; field, proving that T cell recognition of antigen was not Arthur B. Lorber Distinguished Service Award, National contingent on expression of antibody molecules and Jewish Center for Immunology and Respiratory Medicine; was distinct from that of a B cell. These studies laid the and Feodor Lynen Medal for Special Achievement and foundation for their future work that reached into the Distinguished Service Award. realms of structural biology, T cell development/function, and the interface between tolerance and autoimmunity. Kappler’s review panel appointments include service The Kappler-Marrack lab has elucidated the structures of on behalf of NIH (e.g., Transplantation Biology and molecules essential to immune cell function, including Immunology Committee), Immunity (associate editor), the TCR-α chain, H2M, and HLA molecules. In studies Reticuloendothelial Society (journal advisory editor),

18 AAI Newsletter April 2015 Damon Runyon Foundation for Cancer Research MHC. Structural knowledge is also being applied to the (Fellowship Review Committee), and University of study of human diseases caused by T cell recognition of California T Cell Receptor Conference (organizer, 1987). antigens, including metal ions, such as beryllium and A native of Baltimore, Kappler received his B.S. in nickel. Investigation of the mechanisms of action of alum, chemistry from Lehigh University and his Ph.D. in a very commonly used yet poorly understood adjuvant, biochemistry from Brandeis University, after which he has provided information useful to many types of vaccines served as a postdoctoral fellow in the Richard Dutton and has led to the design of a new type of influenza lab at the University of California at San Diego. In 1973, vaccine. In addition, studies of autoimmunity have led he was appointed an assistant professor of oncology at to the identification of a B cell subset present in elderly the University of Rochester and became an associate female, but not male, mice and in animals and patients professor in 1978. He joined National Jewish as a senior with autoimmune disease that may contribute to the faculty member in 1979 and the University of Colorado development of autoimmunity and the gender bias of some Health Science Center as an associate professor the autoimmune diseases. The lab also studies the roles of Bcl- following year, rising to full professor of microbiology/ 2 and related molecules in controlling T cell survival and immunology and of medicine in 1984. He has been works to develop new technologies, such as baculovirus- an HHMI investigator since 1986 and a distinguished based libraries that support studies of T cell specificity. The professor since 1993 and has held his pharmacology central goal of Marrack and Kappler’s diverse work is to department appointment since 1998. better understand immune responses with the hope that this knowledge will eventually lead to advances applicable to human health. Philippa Marrack, Ph.D., AAI ’74, Investigator, Marrack served as AAI president in 2000–2001 and was a Howard Hughes member of the AAI Council from 1995 to 2002. In 2003, she Medical Institute; Chair, was awarded the AAI Lifetime Achievement Award and was Department of Biomedical co-recipient with John Kappler of the 1995 AAI Behring- Research, and Professor, Heidelberger Award. She is a past AAI Distinguished Integrated Department Lecturer and has served on multiple occasions as a of Immunology, National major symposium chair and speaker and as an abstract Jewish Health and programming chair in connection with the AAI annual University of Colorado meeting. In addition to her service on AAI Council, Marrack Health Sciences Center has served on the AAI Nominating Committee (including as chair) and the AAI Program Committee, as an associate and Pippa Marrack studies section editor for The Journal of Immunology, and as an Phillippa Marrack the specificity, survival, AAI delegate to the general assembly of the International and function of T cells. Union of Immunological Societies (IUIS). Her IUIS service Together with John included election to two terms on the IUIS Council, Kappler, she is known for finding that T cells must including as IUIS president (2001-2004). simultaneously recognize MHC and a component of the infectious organism to be activated following Marrack is a member of the National Academy of Sciences, encounter with an infected cell. This discovery led to Institute of Medicine, and Colorado Women’s Hall of Fame the pair’s definitive characterization of the TCR in 1983, and a fellow of the American Academy of Arts and Sciences as well as an explanation of the mechanism of action and the Royal Society. With Dr. Kappler, she has shared the of bacterial superantigens. Early studies also revealed Royal Society’s Wellcome Foundation Prize, the Paul Ehrlich that T cells bearing TCRs specific for self-antigens died and Ludwig Darmstadter Prize (Paul Ehrlich Foundation), in the thymus, presumably leaving only those specific and the Louisa Gross Horwitz Prize (Columbia University). for foreign antigens to mature and enter the periphery. Her additional career honors include: L’Oreal UNESCO More recent work in Dr. Marrack and Dr. Kappler’s joint for Women in Science Award; Bonfils Stanton Award for group continues to address the structural basis for T cell Science; FASEB Excellence in Science Award; Irvington activation, identifying evolutionarily conserved amino Institute Scientific Leadership Award in Immunology; acids of TCRs that are crucial for interaction with MHC William B. Coley Award for Distinguished Research in and working to understand how T cells can distinguish Fundamental Immunology, Cancer Research Institute; between the different highly polymorphic alleles of Avery-Landsteiner Prize, German Society for Immunology; Christopher Columbus Discovery Award for Biomedical

www.aai.org AAI Newsletter 19 Members in the News (continued)

Research; Rabbi Shai Schacknai Memorial Prize; Denver There, she was appointed an assistant professor in 1975, Business Journal scientist award; National Jewish Medical rising to associate professor in 1979. That year, she was and Research Center Lifetime Achievement Award; Pearl appointed a member of the Department of Medicine at Meister Greengard Prize, Rockefeller University; Howard Denver’s National Jewish Hospital and Research Center. In Taylor Ricketts Prize, University of Chicago; Dickson 1980, she joined the faculty of the University of Colorado Prize in Medicine, University of Pittsburgh; and Ernst W. Health Sciences Center as an associate professor; she was Bertner Memorial Award, MD Anderson Cancer Center. appointed a full professor in 1985 and subsequently served Marrack has served on numerous scientific review panels as head of the Division of Basic Immunology. She has on behalf of NIH (e.g., multiple study sections; Center been an HHMI investigator since 1986 and has held her for Scientific Review; NIH Director’s New Innovator appointment as biomedical research chair since 2014. Awards; NIAID Blue Ribbon Panel on Adjuvant Research; NIAID Challenge Grants; NIAID Blue Ribbon Panel on Jeffrey V. Ravetch, M.D., Influenza Research; NIAID Council; and Experimental Ph.D., AAI ’99, Theresa and Immunology Branch, NCI) and the National Academy Eugene M. Lang Professor of Sciences (e.g., National Research Council). She has and Head, Leonard Wagner held additional review panel appointments on behalf Laboratory of Molecular of HHMI, Gates Foundation, National Center for Genetics and Immunology, Complementary and Alternative Medicine, Wellcome Rockefeller University Trust, American Academy of Arts and Sciences, Public Jeff Ravetch and his lab Library of Science, Pew Foundation, Molecular Medicine colleagues analyze the Society, American Society for Cell Biology (Council), influence of variations in B American Cancer Society (Council), Cancer Research cell antibody specificity and Institute, American Foundation for Aging Research, immune cell Fc receptor Sandler Program for Asthma Research, L’Oreal Awards Jeffrey Ravetch expression over the function to Women in Science, Helen Hay Whitney Fellowships, and dysregulation of cellular Damon Runyon Fellowships, FASEB Excellence in immunity, focusing on Science Award, Lasker Award, Sandoz Award, Paul Ehrlich the area of Fc receptor biology. Dr. Ravetch was the first and Ludwig Darmstädter Prize, New York Academy to clone and study Fc receptors for immunoglobulin G of Sciences, European Research Council, Scientific (IgG), showing that these molecules dramatically impact Foundation of Ireland, Oklahoma Medical and Research the effector functions of immune cells. By knocking Foundation, Baylor University, Joslin Diabetes Center, out activating Fc receptors, he demonstrated that these Rockefeller University, Trudeau Institute, and Karolinska molecules were essential to initiating the immune Institute. And she has served as an editorial board complex inflammatory response. His lab subsequently member or reviewer on behalf of journals including showed that expression of inhibitory IgG Fc receptors the Annual Review of Cell and Developmental Biology, on immune cells was critical for the maintenance of Annual Review of Immunology, Annual Review of Cell peripheral tolerance; mice lacking these receptors, Biology, Cell, Cellular Immunology, Current Opinion including FcγRIIB, develop spontaneous and chronic in Immunology, The FASEB Journal, Genome Biology, autoimmune disease. His group later showed that partially Immunity, Journal of Autoimmunity, Journal of Biology, restoring FcγRIIB receptor expression in autoimmune Journal of Experimental Medicine, Molecular Medicine, mice deficient for this molecule can restore tolerance PLOS Biology, Proceedings of the National Academy of and prevent autoimmunity induction. His early interest Sciences USA, Science, and Therapeutic Immunology. in Fc receptors for IgG and their involvement in cellular A native of England, Marrack is a biochemistry graduate immunity led him to an investigation of the mechanism (with first-class honors) of Cambridge University, of action behind intravenous IgG therapy, a seemingly where she earned her Ph.D. in biological sciences. paradoxical treatment for people with autoimmune She undertook postdoctoral training at Cambridge’s disorders (which often involve the overproduction of Girton College and the Medical Research Council (UK) self-reactive IgG antibodies). His group made the key Laboratory for Molecular Biology, then as a Damon finding that a small portion of IgGs used in the therapy Runyon Society for Cancer Research fellow at the contained sialylated Fc receptors, which switched IgGs University of California, San Diego, and subsequently from promoting inflammatory to anti-inflammatory as a postdoctoral fellow at the University of Rochester. responses. His lab has further dissected the mechanism of

20 AAI Newsletter April 2015 action behind intravenous IgG therapy, showing that it of companies including MacroGenics and Virdante suppresses inflammation through a pathway involving Pharmaceuticals. CD209, a molecule discovered by Ravetch’s lab. He also A native of New York City, Ravetch is a molecular continues to explore how structural and biochemical biophysics/biochemistry and English graduate of Yale modifications of antibodies and Fc receptors can University. He earned his Ph.D. from the Rockefeller affect their therapeutic potential, work that has incited University, where he studied under Norton Zinder and a critical change in the strategic design of antibody Peter Model, and received his M.D. from Cornell University therapeutics. In addition to his work on Fc receptors, Medical College. He subsequently completed postdoctoral Ravetch discovered the first chemokine molecule, IP-10, training with Philip Leder at NICHD, NIH, while serving and his early work in malaria research contributed to as a member of the U.S. Public Health Service. In 1982, he the basic understanding of the genetic variability in was appointed an assistant professor at Cornell University Plasmodium falciparum. Medical College and an assistant member of the Memorial An AAI Distinguished Lecturer in 2011, Ravetch was Sloan-Kettering Cancer Center, later achieving associate the recipient of the AAI-Huang Foundation Meritorious and then full rank at both institutions. After having served Career Award (now AAI-Life Technologies Meritorious as a guest investigator at Rockefeller’s Laboratory of Career Award) in 2005. He is a past member of the AAI Cellular Physiology and Immunology during the 1980s, Committee on Public Affairs and has been a major Ravetch joined Rockefeller as a professor in 1996 and has symposium speaker on multiple occasions at the AAI held the Lang Professor appointment there since 1997. annual meeting. He is a faculty member in the Tri-Institutional M.D.-Ph.D. Ravetch is a member of the National Academy of Program jointly administered by Rockefeller, the Weill Sciences and Institute of Medicine (IOM) and fellow Medical College and Graduate School of Medical Sciences of the American Academy of Arts and Sciences and of Cornell University, and the Sloan-Kettering Institute the American Association for the Advancement of at Memorial Sloan Kettering Cancer Center. Since 1993, Science. His additional career honors include: Sanofi- he has also held an adjunct professor appointment at Institut Pasteur Award; Gairdner International Award; Jefferson Medical College and Jefferson Cancer Institute. William Coley Award, Cancer Research Institute (CRI);

Lee C. Howley, Sr., Prize for Arthritis Research; NIH ™ MERIT Award; Boyer Research Award, Memorial Sloan- IMMUNOLOGY 2015 Kettering Cancer Center; Burroughs Wellcome Fund THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS Award in Molecular Parasitology; Pew Scholar Award; MAY 8-12, 2015 | AAI ANNUAL MEETING | NEW ORLEANS, LA Josephson Lecture, Downstate Medical College; Fahey/ Rose Founders Lecture, Clinical Immunology Society; Don’t miss the year’s premier Heidelberger-Kabat Lecture, Columbia University; all-immunology meeting — Grabar Lecture, French Society of Immunology; R. E. ™ Dyer Lecture, NIH; Ecker Lecture, Case Western Reserve IMMUNOLOGY 2015 ! University; and Kunkel Lecture, Henry Kunkel Society. AAI Annual Meeting Abstract A co-founder and co-organizer of the annual Woods Submissions Near All-Time High! Hole Molecular Parasitology Meeting, Ravetch has served on multiple study sections and review panels, Join AAI to Qualify for including at NIH (Task Force on Immunology and Aging), IOM (Committee on Malaria Vaccines), CRI, Discounted Registration Rates Gairdner Foundation, Irvington Institute for Medical Research, Damon Runyon Foundation, and Sanofi- Discounted Hotel Rate Closes Pasteur Award. He has held editorial appointments with April 9, 2015 the Journal of Experimental Medicine and International Immunology and served as a consultant or scientific Visit www. IMMUNOLOGY2015.org advisor for Exelexis Pharmaceuticals, Genentech, Medimmune, MabVax, Millennium Pharmaceuticals, Join AAI or renew your membership to qualify Momenta Pharmaceutical, Morphotek, Novartis, for discounted member registration fees. Visit Portola Pharmaceutical, Regeneron Pharmaceuticals, www.aai.org/membership for more information. Suppremol, and Xencor. He is a founder/co-founder

www.aai.org AAI Newsletter 21 Frank W. and Shirley Fitch Honored at University of Chicago

eading researchers in the scientific lineage of Frank and ex officio member of the AAI Council (1995-2003). LW. Fitch, M.D., Ph.D. (AAI ’61), Albert D. Lasker Hogan recalled that, “Frank came into the position as Professor Emeritus in Pathology and the Ben May Editor-in-Chief (EIC) for The JI 100 percent committed Institute, joined with members of the Fitch family, to his stewardship of the oldest and most important University of Chicago journal in the field. It colleagues, current was neither a part-time and past trainees, and nor a side-job for him. other guests to honor He was determined to Dr. and Mrs. Fitch at the advance the standing inaugural Frank W. and of the journal, not Shirley Fitch Lecture only by publishing the on October 6 at the highest quality science University of Chicago. but also by establishing The inaugural lecture, unquestionable “Immunology Taught integrity for the peer- by Humans,” was review process. He was presented by Mark M. determined to gain the Davis, Ph.D. (AAI ’88), trust of the scientists the Burt and Marion who read and published Avery Family Professor in The JI. To that end, of Immunology at he did not tolerate late Stanford University and or deficient reviews; director of the Stanford worked very hard on the turn-around-time Institute for Immunity, Frank Fitch and daughter Peggy Fitch Rubenstein flanked by Fitch Transplantation, and grandchildren Daniel and Emily Rubenstein from submission to Infection. publication; and he gathered Deputy and Section As detailed previously in the AAI Editors who agreed to meet his Newsletter (October-November standards…which were very, 2014 issue, p. 17), the lectureship very high. Frank’s insistence on was established in 2014 through the scientific integrity, respect for efforts of Dr. Fitch’s former trainees authors, and the communication and colleagues at the University of science are values we uphold to of Chicago and elsewhere. this day.” Among those spearheading the initiative were AAI members The lecture hall in the University Jeffrey A. Bluestone, (AAI ’82), of Chicago Biological Sciences UCSF, Thomas Gajeweki (AAI ’96), Learning Center held a politely University of Chicago, and past waiting audience until about five former AAI President Arthur Weiss minutes before the start of the (AAI ’81), UCSF. They were joined event when trainees flooded in at the inaugural lecture by many and filled the hall to standing- additional AAI member attendees, room only. The mood quickly flipped to noisy and joyful, and including former AAI President Frank Fitch and lecturer Mark Davis Katherine Knight (AAI ’68), after the opening honors, Dr. Fitch Loyola University Chicago Stritch School of Medicine, was given a standing ovation amid AAI Program Chair Wendy Havran (AAI ’85), Scripps much whistling. True to character, Dr. Fitch was humbly Research Institute, and AAI Executive Director Michele and quietly absorbing it all, waving everyone “down” Hogan (AAI ’88), Bethesda, MD. In her role as executive when he felt the attention was too much. But there was editor of The Journal of Immunology (The JI), Hogan no suppressing the admiration for one of science’s true worked closely with Fitch during his tenures as Chair of icons. It was also special that the tribute was proudly the Publications Committee, Editor-in-Chief of The JI, attended by Fitch’s daughter, Peggy Fitch Rubenstein,

22 AAI Newsletter April 2015 and grandchildren, Daniel Rubenstein and Emily Rubenstein. Due to health reasons, Mrs. (Shirley) Fitch was unable to attend, but she was present in spirit and in the hearts of many who know and admire her. Frank Fitch and Mark Davis delivered a brilliant and humorous Michele Hogan lecture —deeply honored to be the first speaker in this lectureship. Following the lecture was a reception for all attendees, followed by yet another reception and dinner off-campus. Here friends and family “roasted” Frank late into the night with fond (and typically very humorous) anecdotes about their interactions with him over the years and the influence he had on their lives. Collectively, they conveyed a sense of the sweep of Dr. Fitch’s remarkable legacy and why he has meant so much—as a scientist, teacher, and mentor—to so many. Frank himself did not let the evening pass without comment. He summed up the event, his career, friendships— and the human condition—with a limerick and a toast. Current plans call for future Frank W. and Shirley Tom Gajewski, Maria Luisa Fitch Lectureships to be presented annually in late Alegre, and September or early October, according to Geoffrey Frank Fitch L. Greene, Ph.D., chair of the Ben May Department for Cancer Research. Lecturers will be selected by a panel comprised of Dr. Greene and several colleagues representing a blend of immunologists and cancer biologists. “The plan,” Greene says, “is to choose lecturers who represent the interface of cancer biology and immunology, to reflect the interests of the Ben May Department for Cancer Research, the Committee on Cancer Biology (CCB), and the Committee on Immunology (COI).” In addition to Greene, selection panelists include Ben May department faculty members Kay Macleod, CCB chair; Alexander Chervonsky (AAI ’96), COI chair; Tom Gajewski (AAI ’96); and Peter Savage (AAI ’11). It is anticipated that the annual autumn lecture will represent the opening seminar for the COI and CCB, both of which have year-long seminar series that extend through June of each year. Prior to his election to AAI Council, tenure as AAI president, and appointment as Editor in Chief for The JI, Fitch provided service on numerous AAI Art Weiss, Wendy Havran, Frank Fitch, and Jeff Bluestone committees, including the Membership, Publications, Awards, and Nominating Committees. He was the AAI representative to the FASEB Public Affairs Committee and the FASEB Board—serving, ultimately as the FASEB See the AAI Newsletter article on the creation of the Frank W. and president (’93). Fitch’s AAI honors include selection as a Shirley Fitch Lectureship http://www.aai.org/About/Publications/ Distinguished Lecturer at the annual meeting (’87) and as AAI_Newsletter/PDFs/2014/AAI_NL_Sep-Oct_2014.pdf the recipient of AAI Career Awards including the Lifetime See also: Fitch Inaugural Lecture Photo Gallery, The Ben May Department Achievement Award (’96), Distinguished Service Award for Cancer Research (University of Chicago) website: https://benmay. (’02), and Excellence in Mentoring Award (’04). uchicago.edu/gallery/fitch-inaugural-lecture-photo-gallery

www.aai.org AAI Newsletter 23 New AAI Career Resource to Be Launched at IMMUNOLOGY 2015™

Early-career PIs, each year, find a wealth of career obligations. “New PIs opening their first labs are facing development resources and opportunities at the AAI many new issues and are often reluctant to seek guidance annual meeting. See pages 46-49 for the many career from their own colleagues,” says Virginia S. Shapiro (AAI development sessions and resources available during ‘04), CSOW chair. “We want to offer young faculty the IMMUNOLOGY 2015™. opportunity to ask questions about lab development and management issues from senior colleagues outside This year, though, you’ll learn about yet another career their home institution. This service is an extension of the resource for AAI members, one that is to be available Careers in Science Roundtable discussions at the annual year round—the AAI Career Advisory Board (CAB) being meeting. Beyond questions on career advice, we defer to launched by the AAI Committee on the Status of Women the members’ home institutions’ mentoring programs and (CSOW). The CAB is a referral service for connecting to other AAI programs, such as GRIP, for assistance with young PIs seeking guidance on specific career issues with grant writing or review.” more senior PIs outside their own institutions offering experience and insights on particular topics. “We want to emphasize that, although this service is launched by the CSOW, the program is open to all (both This new AAI service offers one-on-one career advice men and women). In fact, we are soliciting men as well as for new PIs struggling with such issues as when to women as advisors who agree to be ‘on call,’” says Shapiro. submit that first grant, how to hire a technician/postdoc, and how to balance research with teaching/service

Stop by the AAI Booth (#901) during IMMUNOLOGY 2015TM to learn more about this exciting new program.

The 2015 AAI Vanguard Lecture, “Linking pathogen, New Lecture Name, virulence, immunity, and the microbiota,” will be presented by Gabriel Nuñez, M.D. (AAI ’95), the Paul Same Outstanding de Kruif Endowed Professor in the Department of Pathology at the University of Michigan. The lecture Science will take place on Monday, May 11, 2015, at 11:30 AM in Room 208-209 of the Ernest N. Morial Convention A lecture series that has been a feature of the Center in New Orleans. AAI annual meeting for more than a decade will bear a new name – the AAI Vanguard Lecture – at Listed in order from 2003 to 2014, past presenters in IMMUNOLOGY 2015™ in New Orleans. the lecture series include: Known since its inception in 2003 as the AAI Minority • Richard A. Goldsby, Ph.D. • Emil R. Unanue, M.D. (AAI ’66) Affairs Committee (MAC) Guest Lecture, this annual talk has (AAI ’95) highlighted the high-caliber scientific accomplishments of AAI • Albert Zlotnik, Ph.D. (’85) • Randy R. Brutkiewicz, Ph.D. members who are from ethnic groups historically under-represented • Olivia M. Martinez, Ph.D. (AAI ’89) in biomedical research. AAI has provided this annual forum with (AAI ’91) support in part from a FASEB grant from the National Institute of • Juan Carlos Zúñiga-Pflücker, • Charles E. Egwuagu, M.P.H., General Medical Sciences, NIH. Ph.D. (AAI ’96) Ph.D. (AAI ’02) The new name for the lecture was selected to eliminate any • Diana M. Lopez, Ph.D. (AAI ’76) perception that the event might be geared toward members of under- • Esteban Celis, M.D., Ph.D. represented groups. The AAI Vanguard Lecturers are investigators • Avery August, Ph.D. (AAI ’99) (AAI ’80) at the forefront of biomedical research, and the lecture is meant to • Juan J. Lafaille, Ph.D. (AAI ’05) • Arturo Casadevall, M.D., Ph.D. be of interest to all scientists interested in the presenter’s cutting (AAI ’98) edge research. The new name also connotes researchers whose achievements in science serve as excellent models of professional development for scientists of all backgrounds.

24 AAI Newsletter April 2015 Open to all IMMUNOLOGY 2015™ attendees. Come as you are, directly from the Convention Center. Attendees must be at least 21 years of age. Meeting badge required.

* Lagniappe: a Creole expression pronounced [lay-nee-ap] and meaning “a little something extra” www.aai.org AAI Newsletter 25 Booth 848 Rethink Possible

,V\RXU¾RZWRRVORZ" Rich ,V\RXU(/,6$FRQWHQWWRRORZ" Content From combinatorial profiling, to screening cells and beads together, the iQue® Screener delivers the: Fast Time • Lowest Volume Assays to Results • Fastest Time to Results • Richest Content • Easiest Software You’ll Ever Love Cost Leaders in immunotherapy, immune target Effective screening, and antibody discovery are uncovering new possibilities with IntelliCyt. What’s stopping you? Better Explore your possibilities at Booth 848! Insight

www.intellicyt.com/AAI

True Screening for Immunology PROGRAM PREVIEW

IMMUNOLOGY 2015 ™

AAI PRESIDENT’S PROGRAM

AAI President’s Address FRIDAY, MAY 8, 5:00 PM Ernest N. Morial Convention Center, The Great Hall Linda A. Sherman Scripps Research Institute, AAI President Using Autoimmunity to Inform Tumor Immunity Steven J. Burakoff, The Tisch Cancer Institute Linda A. Sherman Introduction

AAI President’s Symposium: Partners in Crime and T Cell Sleuths MONDAY, MAY 11, 12:30 PM – 2:30 PM The Great Hall Chair: Linda A. Sherman, Scripps Research Institute, AAI President Speakers: MatthewMtMatththeh w FF. WilliamWililliliam R.R HHeHeathaththh Matthew F. Mescher, University of Minnesota Mescher Programming of naive CD8 T cells to develop function and memory William R. Heath, University of Melbourne Tissue-resident memory in viral and parasite immunity Linda S. Wicker, University of Cambridge From autoimmune disease genetics to immune-based therapies Charles D. Surh, Academy of Immunology and Microbiology, Institute for Basic Science, Pohang, Korea Regulation of immune homeostasis to commensal bacterial LindaLiLinddaa SS. WiWickerckek r CharlesChCharlel s D.D SurhSSurhh and dietary antigens AAI President’s Symposium Partners in Crime and T Cell Sleuths

purifying MHC molecules. Together, we demonstrated that MHC molecules contained all the information required for induction of a secondary response by alloantigen-specific cytolytic T lymphocytes. Of course other information is required for naive T cell activation, such as costimulation as demonstrated by our past AAI president Marc Jenkins. Matt Mescher has been at the forefront of demonstrating the important role of yet a third signal, inflammatory cytokines, which we will hear about in this symposium.

William R. Heath. Years later at The Scripps Research Institute (TSRI), Bill Heath and I further demonstrated that Linda A. Sherman allogeneic MHC molecules contained peptides that were also AAI President required for TCR recognition. Bill, who was a postdoctoral fellow at the time, then went on to a highly successful career hen I first learned that my colleagues had in cellular immunology. Recently, he and his long-term honored me with the privilege of representing collaborator Frank Carbone have turned their attention to them on AAI Council and that one day I would W the importance of tissue-resident T cells in defense against become president of AAI, I thought about how lucky I was pathogens, a field they have helped to pioneer. to have gone into research. Of course, luck played a part in my being accorded this honor, but a larger part was due to Linda S. Wicker. I first met Linda Wicker at a conference the patience of my mentors and the hard work and talent on diabetes when I talked about a new model my lab had of the trainees I have had the privilege to mentor. And then developed for looking at the activation of islet antigen- there are the colleagues with whom I have collaborated over specific CD8 T cells in draining lymph nodes of diabetes- the years, each of whom greatly enriched the scope of my prone NOD mice. Linda wrote the book on the genetic basis research, and, importantly, whom I treasure as dear friends. of the development of diabetes in NOD mice and wondered whether our model could be used to dissect the cellular This year’s President’s Symposium takes a slightly different consequences of the genetic polymorphisms that contributed direction from most. Rather than focusing on a single topic, I to disease. This led to some of the most stimulating have focused on the research of several highly accomplished scientific conversations I have ever had and to a long-term immunologists who also happen to have been my highly collaboration. Her work on the genetics of type 1 diabetes valued collaborators. If there is a scientific link in their and the immunological consequences in mice and humans research, it is that at some point in their careers, our research has led to numerous breakthroughs in the field and, now, to intersected. These are my close collaborators and friends— an immunotherapeutic approach to the disease that we will or, as I call them, my “partners in crime.” I apologize for such hear about in this symposium. self-indulgence, but I considered this opportunity to bring together, in one session, colleagues whom I greatly admire Charles D. Surh. Charlie Surh started as a postdoctoral and respect to be one of the great privileges associated with fellow at TSRI with Jon Sprent and advanced through the my tenure as president of AAI! ranks to become professor. Their talent and ingenuity in the areas of thymic development, tolerance, and homeostasis is Matthew F. Mescher. When I went to Harvard Medical School legendary. Recently, Charlie’s research on homeostasis led to work as a postdoctoral fellow with Steve Burakoff and him to South Korea, where he was provided an opportunity Baruj Benacerraf, I selected a project that was at the very to set up his own institute to study the role of gut antigens in heart of T cell biology and a great mystery at that time, the lymphocyte homeostasis and development of the immune molecular basis for TCR recognition. We knew the MHC system. He has the only mouse colony in the world that has was important, but there was great debate about whether not only germ-free, but also antigen-free mice. This work has other molecules contributed as well. Matthew Mescher was provided a window into the fundamental role of antigen in a newly minted assistant professor who had come from the development of the immune system, a role we will hear Strominger’s lab and wanted to address this question by about in this symposium.

28 AAI Newsletter April 2014 LECTURES AND AWARD PRESENTATIONS

AAI DISTINGUISHED LECTURERS

SATURDAY,SSATURDAY MAYMAY 9 SUNDAY,SSUNDAY MAYMAY 1010 MONDAY,MMONDAY MMAYAY 1111 66:00 PM, THE 66:00 PM, THE 66:00 PM, THE GGREAT HALL GGREAT HALL GGREAT HALL

CChristine A. Biron AAlbert S. Bendelac DDennis R. Burton BBrown University UUniversity of Chicago Scripps Research InstituteIn Fuzzy borders in innate and adaptive Innate and innate-like lymphocytes Broadly neutralizing antibodies immunity: experience conditions NK and evolved to counter the structure CD8 T cell responses during viral infection and variability of HIV and provide a basis for vaccine design

AAI Lifetime Achievement Award Presentation AAI-BD Biosciences Investigator Award FRIDAY, MAY 8, 5:00 PM Presentation and Lecture The Great Hall Generously supported by BD Biosciences Chair: SATURDAY, MAY 9, 4:30 PM – 5:30 PM Linda A. Sherman, Scripps Research Institute, AAI President The Great Hall AAward Recipient: Chair: JJonathan Sprent, Garvan Institute of Linda A. Sherman, Scripps Research Institute, AAI President Medical Research AwardA Recipient: AAAI President Linda A. Sherman will introduce Thirumala-DeviT Kanneganti, St. Jude tthe awardee and present the award prior to the Children’s Research Hospital sstart of the President’s Address. RegulatorsR of inflammatory responses TThe AAI Lifetime Achievement Award is the highest AAIA President Linda A. Sherman and BD honor bestowed by the AAI Council upon an AAI member. This award BiosciencesB Vice President of Market Development recognizes a deserving member for a career of scientific achievement RobertR Balderas will introduce the awardee and for contributions to AAI and fellow immunologists. anda present the award immediately prior to Dr. Kanneganti’s lecture. AAI Distinguished Service Award Presentation The AAI-BD Biosciences Investigator Award recognizes an early- SATURDAY, MAY 9, 1:00 PM career investigator who has made outstanding contributions to the field of immunology. Room 206-207

Chair: AAI-BioLegend Herzenberg Award Presentation M. Michele Hogan, AAI Executive Director Generously supported by BioLegend AAward Recipient: SATURDAY, MAY 9, 6:00 PM EElizabeth J. Kovacs, Loyola University Chicago The Great Hall SStritch School of Medicine Chair: AAAI Executive Director M. Michele Hogan will Linda A. Sherman, Scripps Research Institute, AAI President inintroduce the awardee and present the award dduring the AAI Business Meeting & Awards AwardA Recipient: PPresentations session. MatthewM D. Scharff, Albert Einstein College of Medicine TThis Distinguished Service Award recognizes Dr. Kovacs for outstanding service to AAI and the immunology AAIA President Linda A. Sherman and Leonore A. community as member and Chair of the AAI Committee on Herzenberg,H Professor (Research) of Genetics, Public Affairs, 2007–2014. StanfordS School of Medicine, will introduce the awardeea and present the award prior to the start ofo Saturday’s Distinguished Lecture. The AAI-BioLegend Herzenberg Award, named in honor of Leonard Herzenberg, recognizes outstanding research contributions to the field of immunology in the area of B cell biology.

www.aai.org AAI Newsletter 29 The American Association of Immunologists thanks the following sponsors for their generous support of IMMUNOLOGY 2015™ AAI Annual Meeting | May 8–12, 2015 | New Orleans, Louisiana Thank you to our Premier Sponsors

PLATINUM SPONSORS

IMMUNOLOGY 2015™ Gala Opening Night Welcome Reception Service Appreciation Reception Chambers-eBioscience Memorial Award Lefrançois-BioLegend Memorial Award Lustgarten-eBioscience Memorial Award AAI-BioLegend Herzenberg Award Meeting Bags Meeting Lanyards Program Support

GOLD SPONSOR SILVER SPONSORS

AAI Underrepresented Scientist Travel Awards AAI-BD Biosciences AAI-Thermo Fisher Support for AAI Vanguard Lecture Investigator Award Meritorious Career Award Program Support AAI Early Career Faculty AAI-Thermo Fisher Trainee Travel Grants Achievement Awards AAI Trainee Abstract Awards AAI Laboratory Travel Grants

BRONZE SPONSOR SUSTAINING SPONSOR

Program Support Program Support

SUPPORTING SPONSORS CONTRIBUTING SPONSORS

Lead Sponsor of Mobile App The JI Editorial Board Dinner Program Support Meeting Bag Insert and Meeting OTHER SUPPORT

HENRY J. SHOWELL General Meeting Support General Meeting Support Pfizer-Showell Travel Award 30 AAI Newsletter April 2015 LECTURES AND AWARD PRESENTATIONS

AAI-Steinman Award for Human Immunology AAI-Thermo Fisher Meritorious Career Award Research Presentation and Lecture Presentation and Lecture SUNDAY, MAY 10, 4:30 PM – 5:30 PM Generously supported by Thermo Fisher Scientific The Great Hall MONDAY, MAY 11, 4:30 PM – 5:30 PM Chair: The Great Hall Linda A. Sherman, Scripps Research Institute, AAI President Chair: Award Recipient: Linda A. Sherman, Scripps Research Institute, AAI President Mary Ellen Conley, Rockefeller University AAward Recipient: Patients with defects in B cell development RRonald N. Germain, National Institute of AAI President Linda A. Sherman will Allergy and Infectious Diseases, National introduce the awardee and present the award Institutes of Health immediately prior to Dr. Conley’s lecture. DDeveloping a quantitative spatiotemporal understanding of immunity using imaging The AAI-Steinman Award for Human and systems biology Immunology Research, named in honor of Ralph Steinman, recognizes an individual who has made significant contributions AAAI President Linda A. Sherman and Thermo to the understanding of immune processes underlying human Fisher Scientific Senior Market Development disease pathogenesis, prevention, or therapy. Manager Jeff Croissant will introduce the awardee and present the award immediately prior to Dr. Germain’s lecture. 2015 FASEB Excellence in Science Award The AAI-Thermo Fisher Meritorious Career Award recognizes a mid-career scientist for outstanding research contributions to the Presentation and Lecture field of immunology. Sponsored by the Federation of American Societies for Experimental Biology (FASEB) AAI BUSINESS MEETING & AWARDS PRESENTATIONS MONDAY, MAY 11 - 10:15 AM – 11:15 AM Room 208-209 SATURDAY, MAY 9, 1:00 PM - 2:30 PM Chair: Room 206-207 Virginia Shapiro, Mayo Clinic; AAI Committee on the Status of Women Chair AAI reports on the “state of the association” to its members at every AAI annual meeting. Members will hear from the Co-chair: Executive Director, the Secretary-Treasurer, the Editor-in-Chief Margaret K. Offermann, Immediate Past President, FASEB of The Journal of Immunology (The JI), and the Chair of the AAward Recipient: Committee on Public Affairs on the financial standing of AAI, the DDiane E. Griffin, Johns Hopkins Bloomberg status of The JI, important public policy issues, and other items School of Public Health of interest for the membership. Special 2015 AAI awards will also TThe immune response and clearance of acute be presented during this session. vviral infections AAI annually provides more than 700 AAI meeting Travel TThe FASEB Excellence in Science Award is given Awards and Grants to recognize the promise and bolster the iin recognition of outstanding achievement by professional development of investigators of all career stages, wwomen in biological science. Recipients have including underrepresented scientists and trainees. Travel award furthered progress in a particular discipline through excellence in and grant presentations and acknowledgments will include: research. Presentations AAI Excellence in Mentoring Award Presentation AAI Distinguished Service Award AAI-Thermo Fisher Trainee Achievement Awards MONDAY, MAY 11, 12:30 PM Chambers-eBioscience Memorial Award The Great Hall Lefrançois-BioLegend Memorial Award Chair: Lustgarten-eBioscience Memorial Award Linda A. Sherman, Scripps Research Institute, AAI President Pfizer-Showell Travel Award Award Recipient: Acknowledgments Rafi Ahmed, Emory University School of Medicine AAI Early Career Faculty Travel Grants* AAI Laboratory Travel Grants* AAI President Linda A. Sherman, Susan M. Kaech, Yale University, and E. John Wherry, AAI Underrepresented Scientist Travel Awards University of Pennsylvania, will introduce the Sponsored by FASEB MARC Program under a grant from awardee and present the award prior to the NIGMS, NIH [FASEB MARC Program: T36-GM08059-32] start of the President’s Symposium. AAI Undergraduate Faculty Travel Grants The AAI Excellence in Mentoring Award recognizes exemplary career AAI Trainee Abstract Awards* contributions to a future generation of scientists. AAI Trainee Poster Awards

* Supported in part by BD Biosciences www.aai.org AAI Newsletter 31 AAI MAJOR SYMPOSIA

SATURDAY, MAY 9, 8:00 AM – 11:30 AM SUNDAY, MAY 10, 8:00 AM – 11:30 AM

Major Symposium A: Realizing the Potential of Major Symposium C: Looking Within: Mechanisms Cancer Immunotherapy of Cytosolic Immune Surveillance Chairs: Chairs: Jedd D. Wolchok, Memorial Sloan Kettering Cancer Center Russell E. Vance, HHMI, University of California, Berkeley Padmanee Sharma, University of Texas MD Anderson Zhijian ‘James’ Chen, HHMI, University of Texas Southwestern Cancer Center Medical Center

Speakers: Speakers: Jedd D. Wolchok, Memorial Sloan Kettering Cancer Center Russell E. Vance, HHMI, University of California, Berkeley Combined checkpoint blockade Mechanisms and consequences of inflammasome activation Padmanee Sharma, University of Texas MD Anderson Michaela U. Gack, Harvard Medical School Cancer Center RIG-I-like receptor regulation in virus infection and immunity Immune checkpoint therapies: clinical success and next steps Edward A. Miao, University of North Carolina at Chapel Hill Holbrook Kohrt, Stanford Cancer Institute Inflammasomes in host defense Combination monoclonal antibody therapy: dual tumor and Sunny Shin, University of Pennsylvania Perelman immune targeting School of Medicine Suzanne L. Topalian, Johns Hopkins University School of Medicine Overcoming pathogen-encoded virulence activities to initiate PD-1 pathway blockade in cancer therapy: new frontiers innate immune defense Pramod K. Srivastava, University of Connecticut Zhijian ‘James’ Chen, HHMI, University of Texas Southwestern School of Medicine Medical Center What does a host-protective tumor-specific neo-antigen look like? Innate immune sensing and signaling of cytosolic DNA Steven A. Rosenberg, NCI, NIH Thomas F. Gajewski, University of Chicago The curative potential of T cell transfer immunotherapy Innate immune sensing of tumors via the host STING pathway for human cancer Major Symposium D: Lymphatics and Stroma: Key Major Symposium B: The Microbiota in Immunity Players in the Specialized Lymphoid Organ Niche and Inflammation Chairs: Chairs: Gwendalyn J. Randolph, Washington University Wendy S. Garrett, Harvard School of Public Health School of Medicine Yasmine Belkaid, NIAID, NIH Shannon J. Turley, Genentech

Speakers: Speakers: Yasmine Belkaid, NIAID, NIH Gwendalyn J. Randolph, Washington University From mutualism to parasitism: context and consequences School of Medicine Lymphatics in inflammatory disease Wendy S. Garrett, Harvard School of Public Health The gut microbiome in colitis and colorectal cancer Laura Santambrogio, Albert Einstein College of Medicine Lymph formation, circulation, and immunological role Eric G. Pamer, Memorial Sloan Kettering Cancer Center Microbiota-mediated defense against intestinal infections Reinhold Förster, Hannover Medical School Lymph node homing of immune cells via afferent lymphatics Ami S. Bhatt, Stanford University Exploring the composition of the human superorganism: Troy D. Randall, University of Alabama at Birmingham the microbiome in an immunocompromised host Paradoxical role of the omentum in immunity to peritoneal tumors Bana Jabri, University of Chicago Shannon J. Turley, Genentech Harnessing the interplay between commensals and pathogens Regulation of leukocyte function and territoriality by fibroblastic in septic shock reticular cells Thaddeus S. Stappenbeck, Washington University Biju Parekkadan, Harvard Medical School School of Medicine Lymph node cell therapy Commensal-host interactions in the intestine and their relationship to disease pathogenesis

32 AAI Newsletter April 2015 Unmask cellular heterogeneity

Laissez les bons temps rouler! (Let the good times roll!) at IMMUNOLOGY 2015™, Booth #907

Biology for a better world. NORTH AMERICA: 888.999.1371 EUROPE: +43 1 796 40 40-305 JAPAN: +81 (0)3 6430 4020 INQUIRIES: [email protected]

©Affymetrix,©Affymm Affymetrix,etrixetrix,, InInc.c. AAll llIn rrigrightsigghtshtss rightsreservrreserved.eservvedved. reserved.. ForFor RResearcheseeseao aarch Researchrch Use OOnlyOnly.nlyy. Only.NotNot for Notor useu sefor in nu diagnosticdiagg nostnosticdiagnosticic or therapeutictthhhererr aapeutictherapeuticpeutic pprocprocedures.roc procedures.eedures.dures.

www.aai.org AAI Newsletter 33 AAI MAJOR SYMPOSIA

MONDAY, MAY 11, 8:00 AM – 11:30 AM TUESDAY, MAY 12, 8:00 AM – 11:30 AM

Major Symposium E: Roots and Mechanisms of Major Symposium G: Regulating Immunity: Tregs Human Autoimmunity and Beyond Chairs: Chairs: Eric Meffre, Yale University Steven F. Ziegler, Benaroya Research Institute at Virginia Mason Jane Hoyt Buckner, Benaroya Research Institute at Virginia Mason Claudia Mauri, University College London

Speakers: Speakers: Eric Meffre, Yale University Andrea Cerutti, Mount Sinai School of Medicine Defects in early B cell tolerance checkpoints are common to IgD: an ancestral regulator of Th2 immune responses autoimmune diseases Claudia Mauri, University College London Jane Hoyt Buckner, Benaroya Research Institute at Virginia Mason Microbiota, regulatory B cells, and arthritis: insight into a new Mapping the immune pathways that drive T1D development mechanism of regulation Megan Sykes, Columbia University Jennifer L. Gommerman, University of Toronto New approaches to understanding human allo- and Befuddled B cells and EAE pathogenesis autoimmune responses Mitchell Kronenberg, La Jolla Institute for Allergy & Immunology Erik J. Peterson, University of Minnesota Natural killer T cells: one specificity, but different functions PTPN22 promotes interferogenic signaling in myeloid cells Liang Zhou, Northwestern University Edward K. Wakeland, University of Texas Southwestern Regulation of Tregs in the mucosal tissues Medical Center Steven F. Ziegler, Benaroya Research Institute at Virginia Mason A genomic analysis of systemic autoimmunity Development and function of regulatory T cells Judith A. James, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center Roles for impaired immune regulation in transition from Major Symposium H: Mechanisms of Host preclinical autoimmunity to clinical lupus Immunity: Insights from Eukaryotic Pathogens Chairs: Major Symposium F: Networking through Mobile William C. Gause, New Jersey Medical School, Rutgers, The State Cells and Synaptic Interfaces University of New Jersey Chairs: De’Broski R. Herbert, University of California, San Francisco

Michael L. Dustin, University of Oxford Speakers: Janis K. Burkhardt, Children’s Hospital of Philadelphia De’Broski R. Herbert, University of California, San Francisco and University of Pennsylvania The helminthic harangue on immunity and repair

Speakers: Amariliz Rivera, New Jersey Medical School, Rutgers, The State University of New Jersey Michael L. Dustin, University of Oxford Inflammatory monocytes orchestrate innate antifungal immunity Novel signals in the immunological synapse in the lung Janis K. Burkhardt, Children’s Hospital of Philadelphia and William C. Gause, New Jersey Medical School, Rutgers, The State University of Pennsylvania University of New Jersey Cytoskeletal control of integrin activation at the immunological synapse Helminths, wound healing, and worm expulsion Morgan Huse, Memorial Sloan Kettering Cancer Center Padraic Fallon, Trinity College Dublin Lipid-based patterning of the immunological synapse Helminth activation of innate and adaptive immunity to achieve Clotilde Théry, INSERM U932/Institut Curie chronic infections Exosomes and other extracellular vesicles in communication P’ng Loke, New York University School of Medicine between tumors and the immune system Alternatively activated macrophages derived from monocytes and Anna Huttenlocher, University of Wisconsin tissue-resident macrophages during helminth infections Imaging inflammation: implications to human disease Edward J. Pearce, Washington University School of Medicine Thorsten R. Mempel, Massachusetts General Hospital/ The metabolic regulation of alternative macrophage activation Harvard Medical School Immune cell communication in the tumor environment

34 AAI Newsletter April 2015 See any color you like.

The SP6800 Spectral Analyzer is Sony’s newest and most unique flow cytometry- based system which can expand cell and biomarker research.

See and analyze all wavelengths from 420 nm to 800 nm. Spectrally unmix overlap - ping colors in a single run. Remove inter - fering autofluorescence or analyze auto - fluorescence as an independant color.

Operate powerful software providing new tools, analysis techniques and an easy to use interface.

Visit our website or contact a local sales representative for more information. www.sonybiotechnology.com

Engineering for the Future.

©2015 Sony Corporation. All rights reserved. For Research Use Only. Not for use in diagnostic or therapeutic procedures. The SP6800 Spectral Analyzer is classified as a Class 1 laser product. Blu-ray Disc™ is a trademark of the Blu-ray Disc Association. All other trademarks are property of their respective owners.

www.aai.org AAI Newsletter 35 AAI COMMITTEE – SPONSORED SESSIONS

AAI CLINICAL IMMUNOLOGY COMMITTEE Daniel Rotrosen, Director, Division of Allergy, Immunology and Transplantation, NIAID Recent trends in NIAID-funded, investigator-initiated Translational Research Towards Awakening the immunology research Immune System in Human Disease Bruce Walker, Director, Ragon Institute of MGH, MIT and MONDAY, MAY 11, 3:45 PM – 5:45 PM Harvard; Professor, Harvard University; and Investigator, Howard Hughes Medical Institute Chairs: The role of philanthropy in supporting biomedical research Robert L. Modlin, University of California, Los Angeles AAI Clinical Immunology Committee Chair NIH has long been one of the major sources of funding for immunologists and other biomedical researchers. In recent years, Angela Colmone, Science Translational Medicine, AAAS funding constraints have lowered NIH paylines and reduced success rates, jeopardizing the research and careers of many Speakers: productive and successful scientists. This session will explore some Alan Sher, NIAID, NIH of the alternatives to NIH funding, including patient advocacy A host-directed therapy for TB infection that targets organizations, philanthropists, and crowdfunding. In addition, the innate cytokines session will include an update on immunology research supported Hana Golding, CBER, FDA by the National Institute of Allergy and Infectious Diseases. Novel methods for measuring antibody affinity, epitope diversity, and Attendees will have ample opportunity to ask questions. cross-reactivity in human vaccine trials Drew M. Pardoll, Johns Hopkins School of Medicine Therapeutic manipulation of the microenvironment of cancer Jeffrey A. Bluestone, University of California, San Francisco Rebalancing the immune system through Treg biology Angela Colmone, Science Translational Medicine, AAAS Translational immunology research: into the future

Advances in translational immunology research have led to new approaches to awaken the immune system in the battle against infection, cancer, and autoimmune disease. This session AAI EDUCATION COMMITTEE will include discussion of present approaches and future directions that will be valuable to immunologists interested in translational research. Careers in Biotech: Panel Discussion and Networking AAI COMMITTEE ON PUBLIC AFFAIRS SATURDAY, MAY 9, 7:00 PM – 9:00 PM Chair: Funding for Immunology Research: Non-Federal Nandita Bose, Biothera Opportunities and NIAID Program Update Panelists: SUNDAY, MAY 10, 10:15 AM – 12:15 PM Jason Fontenot, Principal Scientist, Immunology, Biogen Idec Chair: Brian Johnson, Director, Market Development & Product Clifford V. Harding, Case Western Reserve University Management, Thermo Fisher Scientific AAI Committee on Public Affairs Chair Andy I. Kokaji, Senior Scientist, STEMCELL Technologies, Inc.

Speakers: Isharat Yusuf, Research Investigator II, Genomics Institute of the Novartis Research Foundation William Chambers, National Vice President, Extramural Research, American Cancer Society Many opportunities exist in industry for scientists with advanced The role of charitable and patient advocacy organizations in degrees. There are positions in laboratory research, program funding biomedical research management, business development, regulatory affairs, clinical trials Gwen Nguyen, Cause Director, Indiegogo oversight, medical liaison, and more. This panel features scientists How crowdfunding can support biomedical research employed in a variety of positions in industry discussing their career paths and the skills required for success in each. Following the panel Session description continues in column 2 discussion, enjoy casual conversation with the speakers and other scientists from industry at a networking reception.

36 AAI Newsletter April 2015 AAI COMMITTEE – SPONSORED SESSIONS

AAI EDUCATION COMMITTEE & AAI COMMITTEE ON THE STATUS OF WOMEN

Careers in Science Roundtable SATURDAY, MAY 9, 11:30 AM – 1:00 PM

Chair: Virginia Shapiro, Mayo Clinic; AAI Committee on the Status of Women Chair

At this always popular session, you’ll have the opportunity to meet with scientists at your own career stage and with more experienced scientists to explore specific career issues important to men and women in science today. Learn what others are thinking and gain insights into issues you are confronting in your own situation. Recently added topics offer insights into NIH study sections and considerations for scientists in M.D.-Ph.D. careers. The Two Body Problem: dual career couples Choose from these and the other vital topics related to the Table Leaders: Susan Kovats, Oklahoma Medical Research environment you work in (academic research, biotech industry, Foundation; Sunny Shin, University of Pennsylvania School governmental agencies, non-profits), the transitions between of Medicine specific career stages, or issues in balancing career and family in Balancing Parenthood and Career any career path. Don’t miss this great networking opportunity! Table Leaders: Shabaana Khader, Washington University School Registration Fee: $20 (Lunch included) of Medicine; Carolina Lopez, University of Pennsylvania School of Veterinary Medicine Discussion topics and table leaders: Careers in Biotech and Industry: moving from academia to industry Research Careers in Academia and vice versa Table Leaders: Renold Capocasale, Flowmetric, Inc • Graduate Student to Postdoc: finding a postdoc, interviewing Pooja Jain, Drexel University College of Medicine Table Leaders: Louise M. D’Cruz, University of Pittsburgh Michelle A. Parent, University of Delaware Careers at Governmental Agencies (FDA/NIH/USDA/CDC) Gwendalyn J. Randolph, Washington University School Table Leaders: Yasmine Belkaid, NIAID, NIH of Medicine Avinash Bhandoola, NCI, NIH • Postdoc to PI: finding a position, interviewing, negotiating, NIH Study Section Insights lab start-up Table Leaders: Scheherazade Sadegh-Nasseri, Johns Hopkins Table Leaders: Deborah M. Brown, University of Nebraska, Medical Institute; Virginia S. Shapiro, Mayo Clinic Lincoln; Lisa H. Butterfield, University of Pittsburgh Negotiating an Academic Position Lauren A. Zenewicz, University of Oklahoma Health Table Leaders: Sarah L. Gaffen, University of Pittsburgh Sciences Center Paula M. Lutz, University of Wyoming • New PI: attracting students and postdocs, preparing for tenure The Physician Scientist: balancing clinical and research duties Table Leaders: Robin Stephens, University of Texas Medical Table Leaders: David D. Chaplin, University of Alabama, Branch; Emma H. Wilson, University of California, Riverside Birmingham; Jonathan Maltzman, University of • Undergraduate Institutions: finding the balance in teaching, Pennsylvania; Penelope A. Morel, University of Pittsburgh doing research Research from the M.D., Ph.D. Perspective Table Leaders: Laurie P. Shornick, St. Louis University Table Leaders: Robin G. Lorenz, University of Alabama, • Mentoring Effectively Birmingham; Wayne M. Yokoyama, Washington University Table Leaders: Elizabeth E. Brown, University of Alabama, School of Medicine Birmingham; Federica Sallusto, Institute for Research in Non-Research Careers for Scientists: careers in scientific journals, Biomedicine, Bellinzona, Switzerland program administration, non-profits, industry How to Build a Network Table Leaders: Peggy Just, eBioscience, an Affymetrix Table Leaders: Gail A. Bishop, University of Iowa business; Jennifer H. Meyers, The American Association of Dawn Jelley-Gibbs, Taconic Bioscience Immunologists and The Journal of Immunology Madeleine W. Cunningham, University of Oklahoma Health Kristen Porter, NIAID, NIH Sciences Center

www.aai.org AAI Newsletter 37 AAI COMMITTEE – SPONSORED SESSIONS

AAI MINORITY AFFAIRS COMMITTEE AAI Vanguard Lecture MONDAY, MAY 11, 11:30 AM – 12:30 PM Careers Roundtable and Speed Networking Session Supported in part by a grant to the Federation of American Societies SATURDAY, MAY 9, 11:45 AM – 2:15 PM for Experimental Biology (FASEB) from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health Supported in part by a grant to the Federation of American Societies [FASEB MARC Program: T36-GM08059-32] for Experimental Biology (FASEB) from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health Chair: [FASEB MARC Program: T36-GM08059-32] Cherié L. Butts, Biogen Idec; AAI Minority Affairs Committee Chair Chair: Speaker: Cherié L. Butts, Biogen Idec; AAI Minority Affairs Committee Chair GabrielG Núñez, University of Michigan Networking skills have never been more crucial to ensure success LinkingL pathogen virulence, immunity, for early/mid-career scientists, including those traditionally and the microbiota under-represented in biomedical research. At the roundtable, take advantage of the opportunity to meet in small-group format SSince 2003, the AAI meeting has featured a with accomplished, senior immunologists to hear how they have sscientific lecture presented by an AAI member handled the career challenges you now face and learn what they wwho is an underrepresented minority investigator. believe will work for you today. Then practice networking in a SSelected for their achievements in the field of relaxed environment offering a structured networking exercise immunology, presenters are among the most prominent investigators and personalized feedback on communicating your scientific in the field and models of successful career development. interests/objectives most effectively. Registration Fee: $20

(Includes lunch; coffee/cookies during networking hour) AAI PROGRAM COMMITTEE Discussion topics and table leaders: Grad Student: finding a mentor; taking aim at postdoc training AAI Program Committee Workshop: Back to School: Table Leaders: Eduardo Davila, University of Maryland Greenebaum A Review of Four Fast-Moving Fields Cancer Center; Santiago Partida-Sanchez, Nationwide Children’s Hospital; Tonya Webb, University of Maryland School of Medicine FRIDAY, MAY 8, 2:30 PM – 4:30 PM Postdoc: finding a mentor; taking aim at a faculty position Chairs: Table Leaders: Robert J. Binder, University of Pittsburgh Wendy L. Havran, Scripps Research Institute; AAI Program De’Broski R. Herbert, University of California, San Francisco Committee Chair Joseph Larkin, University of Florida Maria-Luisa Alegre, University of Chicago Junior Faculty: preparing for promotion and tenure Table Leaders: Avery August, Cornell University College of Veterinary Speakers: Medicine; Arturo Casadevall, Albert Einstein College of Medicine; Prosper Boyaka, Ohio State University Jian Han, HudsonAlpha Institute for Biotechnology NextGen sequencing of immune repertoire: technology, applications, Academia or Industry: how to decide (or switch sides) and challenges Table Leaders: Jonathan A. Deane, GNF/Novartis Karel Otero Gutierrez, Biogen Idec Russell G. Jones, McGill University Metabolomics in immunity Government Agency Careers: CDC, FDA, NIH Table Leaders: Marta Catalfamo, NIAID, NIH; Charles Egwuagu, Melody A. Swartz, University of Chicago NEI, NIH; Alison Mawle, Centers for Disease Control and Prevention Immunoregulatory roles of lymphatic endothelium and their transport functions Non-Research Careers (e.g., entrepreneurship, law/policy) Table Leaders: James. W. Lillard, Morehouse School of Medicine and Kevin J. Tracey, The Feinstein Institute for Medical Research JYANT Technologies, Inc. (President/CEO); Evolutionary integration of neural and immune pathogen sensing Jaconda Wagner, Wagner Law LLC (intellectual property attorney) and response This workshop intends to bring a broad audience up-to-date on a few emerging or rapidly changing fields or areas of technological innovation. Expert lecturers will provide an overview of each trending topic with an emphasis on communicating big picture concepts.

38 AAI Newsletter April 2015 AAI COMMITTEE – SPONSORED SESSIONS

AAI PUBLICATIONS COMMITTEE AAI VETERINARY IMMUNOLOGY COMMITTEE

Publishing Scientific Articles: Advice and AAI Veterinary Immunology Committee & Admonition American Association of Veterinary Immunologists SUNDAY, MAY 10, 12:30 PM – 2:00 PM (AAVI) Joint Symposium—Vaccines for the Modern Era: Implications for Human and Animal Health II Chairs: SATURDAY, MAY 9, 12:30 PM – 2:30 PM Eugene M. Oltz, Washington University School of Medicine AAI Publications Committee Chair Chairs: Pamela J. Fink, University of Washington School of Medicine Laurel J. Gershwin, University of California, Davis; AAI Veterinary Editor-in-Chief, The Journal of Immunology Immunology Committee Chair Crystal Loving, National Animal Disease Center, ARS, USDA Speakers: American Association of Veterinary Immunologists President Eugene M. Oltz, Washington University School of Medicine Composing a masterpiece: make your data sing Speakers: Robert L. Fairchild, Cleveland Clinic W. Ray Waters, National Animal Disease Center, ARS, USDA My most excellent paper was returned with serious reviewer issues: Vaccine approaches for bovine tuberculosis: correlates of protection and what do I do now? relevance to human tuberculosis Pamela J. Fink, University of Washington School of Medicine Volker Gerdts, Vaccine and Infectious Disease Organization-InterVac, How to stay on the right side of the ethics divide University of Saskatchewan Large animal models for human vaccine research: pertussis, RSV, In this session, experienced editors will provide valuable insights and others in understanding the process of preparing a manuscript and Barney S. Graham, Vaccine Research Center, NIAID, NIH responding to reviewers’ comments. Panelists will address questions Structure-guided development of an RSV vaccine such as: When writing a manuscript, what steps can an author take to enhance its impact on editors, reviewers, and, if accepted Crystal Loving, National Animal Disease Center, ARS, USDA for publication, on readers? What are recommended practices for Provocation versus protection: immune responses and differential responding to reviewers’ comments? How can authors enhance outcomes following influenza virus vaccination and challenge the presentation of data in figures? In addition, the Editor-in-Chief in pigs of The Journal of Immunology will speak on how to avoid possible ethical missteps in scientific publishing. This symposium will feature topics on both human and veterinary vaccines, with emphasis on new technologies and new information for more appropriate targeting of the immune response to achieve protective immunity. Advances in understanding immune responses to veterinary and human pathogens and applications of that information to vaccine design illustrate a commonality that supports the current “one health” concept in medicine.

www.aai.org AAI Newsletter 39 NIH INSTITUTE-SPONSORED SYMPOSIA

NIH INSTITUTE-SPONSORED SYMPOSIA National Institute of Allergy and Infectious Diseases (NIAID) Workshop: Inflammation as an National Cancer Institute (NCI) and Radiation Immunological Determinant of HIV Transmission Research Society (RRS) Symposium: Symbiosis SUNDAY, MAY 10, 12:30 PM – 2:30 PM of Radiation and Immunology: Basic and Translational Impact Organizers: MONDAY, MAY 11, 8:00 AM – 10:00 AM Anjali Singh, NIAID, NIH Alan Schultz, NIAID, NIH Chairs: Chairs: Mansoor Ahmed, NCI, NIH Jonathan A. Harton, Albany Medical Center Chandan Guha, Albert Einstein College of Medicine Jim A. Turpin, NIAID, NIH Speakers: Panelists: Mansoor Ahmed, NCI, NIH Opening/meeting interaction Michael R. Betts, University of Pennsylvania Gayle E. Woloschak, Northwestern University Daniel C. Douek, NIAID, NIH Introduction: Information on Radiation Research Society (RRS) Mimi Ghosh, George Washington University Ralph R. Weichselbaum, University of Chicago Medicine Ashley T. Haase, University of Minnesota Basic radiation biology: fatal attraction for immunologists Eric Hunter, Emory University Yang-Xin Fu, University of Chicago Immunologist’s experiences of collaborating with the field of David Masopust, University of Minnesota radiation biology Christopher J. Miller, University of California, Davis Chandan Guha, Albert Einstein College of Medicine Kristen A. Porter, NIAID, NIH Opportunities for immunology in clinical radiotherapy Barbara L. Shacklett, University of California, Davis Lisa M. Coussens, Oregon Health & Science University Tumor immune microenvironment The objective of this panel discussion is to probe the relationship between inflammation and susceptibility to HIV infection National Institute of Allergy and Infectious and to identify novel avenues for HIV prevention, targeting mucosal microenvironment inflammation to limit HIV target cell Diseases (NIAID) Symposium: Hitting the Mother availability. The panel will highlight recent findings and research Lode: Mining the Data Fields gaps to address the key questions and challenges. SATURDAY, MAY 9, 12:30 PM – 2:30 PM

Chairs: Alison Deckhut Augustine, NIAID, NIH Ashley Xia, NIAID, NIH Speakers: Atul J. Butte, Stanford University Translating a trillion points of data into therapies, diagnostics, and new insights into disease Steven H. Kleinstein, Yale University The transcriptional response to influenza infection and vaccination Anjana Rao, La Jolla Institute for Allergy and Immunology Genomics approaches to understanding immune function Martin S. Zand, University of Rochester Start making sense: visualization and modeling of high- dimensional data

40 AAI Newsletter April 2015 GUEST SOCIETY SYMPOSIA

National Institute on Aging (NIA) Symposium: GUEST SOCIETY SYMPOSIA Rejuvenating the Aged Immune System: New Directions for Targeting Interventions American Association of Veterinary SATURDAY, MAY 9, 3:45 PM – 5:45 PM Immunologists (AAVI) & AAI Veterinary Immunology Committee Joint Symposium: Chairs: Vaccines for the Modern Era: Implications for Janko Nikolich-Zugich, University of Arizona College of Medicine Human and Animal Health II Rebecca A. Fuldner, NIA, NIH SATURDAY, MAY 9, 12:30 PM – 2:30 PM

Speakers: Chairs: Nancy R. Manley, University of Georgia Laurel J. Gershwin, University of California, Davis Too much is not enough: Foxn1 and the maintenance of the postnatal thymus Crystal Loving, National Animal Disease Center, ARS, USDA Jorg J. Goronzy, Stanford University Speakers: miRNA regulation of T cell responses in older individuals W. Ray Waters, National Animal Disease Center, ARS, USDA Janko Nikolich-Zugich, University of Arizona College of Medicine Vaccine approaches for bovine tuberculosis: correlates of protection and Age-related changes in metabolic programming and trafficking of relevance to human tuberculosis T cells: lessons from parabiosis Volker Gerdts, Vaccine and Infectious Disease Organization-InterVac, Donna M. Murasko, Drexel University University of Saskatchewan Enhanced IgG response to influenza vaccine in aged mice with a Large animal models for human vaccine research: pertussis, RSV, novel adjuvant, rOv-ASP-1 and others Barney S. Graham, Vaccine Research Center, NIAID, NIH Structure-guided development of an RSV vaccine National Institute of Environmental Health Sciences (NIEHS) Symposium: Developmental Exposures and Crystal Loving, National Animal Disease Center, ARS, USDA Their Effects on Immune System Function Provocation versus protection: immune responses and differential outcomes following influenza virus vaccination and challenge SUNDAY, MAY 10, 12:30 PM – 2:30 PM in pigs

Chairs: American Society for Reproductive Immunology Michael C. Humble, NIEHS, NIH (ASRI) Symposium: Innate Immunity in Pregnancy B. Paige Lawrence, University of Rochester SATURDAY, MAY 9, 10:15 AM – 12:15 PM Speakers: Chairs: John B. Barnett, West Virginia University Long-term changes in the immune system due to prenatal Vikki M. Abrahams, Yale School of Medicine cadmium exposure Mukesh K. Jaiswal, Rosalind Franklin University of Medicine B. Paige Lawrence, University of Rochester and Science The environmental legacy of pollutants: linking developmental Speakers: exposures to perturbations in antiviral immune responses Emmet Hirsch, NorthShore University Health System Kari C. Nadeau, Stanford University Autophagy in preterm labor Mechanistic approaches to epigenetics and toxicant exposures Vikki M. Abrahams, Yale School of Medicine Judith T. Zelikoff, New York University School of Medicine Mechanisms of placental inflammation in obstetric Maternal inhalation of ambient particulate matter causes antiphospholipid syndrome alterations in immune profiles and anti-tumor mechanisms in juvenile murine offspring Mukesh K. Jaiswal, Rosalind Franklin University of Medicine and Science IL-22 prevents lipopolysaccharide-induced preterm labor in mice Gil Mor, Yale School of Medicine Role of placenta type I interferon on polymicrobial infection- induced preterm birth

www.aai.org AAI Newsletter 41 GUEST SOCIETY SYMPOSIA

American Society of Transplantation (AST) Chinese Society of Immunology (ChSI) Symposium: Symposium: T Cell Trafficking during Differentiation and Regulation Alloimmunity and Tolerance of Lymphocytes SATURDAY, MAY 9, 12:30 PM – 2:30 PM SATURDAY, MAY 9, 8:00 AM – 10:00 AM

Chairs: Chairs: Mandy L. Ford, Emory University Zhigang Tian, University of Science and Technology of China Maria-Luisa Alegre, University of Chicago Olivera J. Finn, University of Pittsburgh School of Medicine Speakers: Speakers: Donna L. Farber, Columbia University Medical Center Zhigang Tian, University of Science and Technology of China Tissue-resident human memory T cells in transplantation Development and differentiation of liver-resident NK cells and immunity Bing Sun, Institute Pasteur of Shanghai, Chinese Academy Kimberly D. Klonowski, University of Georgia of Sciences IL-15-mediated control of memory T cell glycosylation Extracellular Matrix Protein 1 plays a critical role in driving Th2 cell and trafficking migration and controlling Th17 cell differentiation Daniel Kreisel, Washington University School of Medicine Liwei Lu, University of Hong Kong Tolerogenic role of central memory T cells in lung transplantation Regulatory B cells in autoimmunity Bryna Burrell, Immune Tolerance Network Hai Qi, Tsinghua University Laminins affect T cell trafficking and allograft fate Follicular T helper cells and germinal center reaction Zhongjun Dong, Tsinghua University Canadian Society for Immunology (CSI) Metabolic regulation of NK cell development and activation Symposium: T Lymphocyte Regulation and Differentiation during Infection German Society for Immunology (DGfI) MONDAY, MAY 11, 8:00 AM – 10:00 AM Symposium: Control of Treg/Th17 Differentiation MONDAY, MAY 11, 3:45 PM – 5:45 PM Chairs: Irah L. King, McGill University Chairs: Jude E. Uzonna, University of Manitoba Hans-Martin Jäck, University of Erlangen Dieter Kabelitz, University of Kiel Speakers: Carsten Watzl, Leibniz Research Center, Dortmund Jun Wang, Dalhousie University Diverse immune mechanisms for shaping anti-Chlamydia CD4 Speakers: T cell responses Jürgen Wienands, University of Göttingen Simona Stäger, INRS-Institut Armand Frappier Immunology in Germany The role of inflammation in regulating the development of T cell responses during leishmaniasis Tim Sparwasser, University of Hannover Metabolic influences that regulate CD4 T cell function Irah L. King, McGill University The role of integrins in T follicular helper cell maintenance Vigo Heissmeyer, University of Munich following helminth infection Post-transcriptional control of Th17 differentiation S. M. Mansour Haeryfar, University of Western Ontario Petra Hoffmann, University of Regensburg Invariant T cell responses to bacterial superantigens Impact of Treg cell plasticity on adoptive cell therapies Jude E. Uzonna, University of Manitoba Jochen Hühn, Helmholtz Society, Braunschweig MHC class II-restricted innate-like double negative T cells display Epigenetic control of regulatory T cell development memory characteristics and contribute to optimal anti- Michael Lohoff, University of Marburg Leishmania immunity The role of interferon regulatory factors for T cell subset differentiation

42 AAI Newsletter April 2015 GUEST SOCIETY SYMPOSIA

International Complement Society (ICS) Japanese Society for Immunology (JSI) Symposium: Key Roles of Complement in Adaptive Symposium: Development and Function of Immunity, Pathogen Responses, and Human Immune Cells: Symposium by JSI Awardees Disease SATURDAY, MAY 9, 12:30 PM – 2:30 PM SUNDAY, MAY 10, 10:15 AM – 12:15 PM Chairs: Chairs: Toshinori Nakayama, Chiba University Andrea J. Tenner, University of California, Irvine Ryoji Yagi, Chiba University Joshua M. Thurman, University of Colorado School of Medicine Speakers: Speakers: Yosuke Kurashima, University of Tokyo Claudia Kemper, King’s College London Analysis of a mast cell-suppressive milieu on the body surface for Regulation of T lymphocyte programming by autocrine complement the prevention and treatment of inflammatory diseases Brian Geisbrecht, Kansas State University Satoshi Nishimura, Jichi Medical University Utilization of complement evasion strategies by pathogens Immune cell activation in obese adipose tissue: visualization by Susan Lea, University of Oxford two photon microscopy Illuminating mechanisms of complement-pathogen interactions Yoshiki Omatsu, Kyoto University from structural biology Molecular mechanism of formation of bone marrow niche for V. Michael Holers, University of Colorado School of Medicine hematopoietic stem/progenitor cells and immune cells Targeting complement and its activation mechanisms: successful Takashi Satoh, Osaka University interventions in human disease and new strategies going forward The physiological role and differentiation mechanism of disorder- specific M2 macrophages International Cytokine and Interferon Society Ryoji Yagi, Chiba University (ICIS) Symposium: Innate and Adaptive Immune Role of the transcription factor GATA3 in helper T cell and innate Recognition lymphoid cell development SATURDAY, MAY 9, 3:45 PM – 5:45 PM Toshinori Nakayama, Chiba University Pathogenic memory Th2 cells in airway inflammation Chairs: Richard A. Flavell, HHMI, Yale School of Medicine Korean Association of Immunologists (KAI) and Sarah L. Gaffen, University of Pittsburgh Association of Korean Immunologists in America (AKIA) Symposium: Cellular and Molecular Speakers: Factors that Control Immunity Luke A. J. O’Neill, Trinity College Dublin Metabolic reprogramming in innate immunity MONDAY, MAY 11, 10:15 AM – 12:15 PM

Federica Sallusto, Institute for Research in Biomedicine Chairs: Polarized T cell responses to pathogens and vaccines Booki Min, Cleveland Clinic Foundation Andrew N. McKenzie, Cambridge Immunology Network Chong-Kil Lee, Chungbuk National University Type-2 innate lymphoid cells at the interface with adaptive immunity Speakers: Curt M. Horvath, Northwestern University Woong-Kyung Suh, Clinical Research Institute of Montreal Regulation of viral RNA recognition, innate immune signaling, Dissection of inducible costimulator (ICOS) signaling components and antiviral gene expression in follicular helper T cell and Th17 responses Eun Young Choi, Seoul National University CD8 T cells can generate memory cells without CD4 help when antigen is cleared early enough Sang-Moo Kang, Georgia State University Roles of innate and adaptive immune components in inducing protective immune responses to influenza vaccination Myoung Ho Jang, Institute for Basic Science, Pohang Eosinophils regulate inflammation in the gut

www.aai.org AAI Newsletter 43 GUEST SOCIETY SYMPOSIA

Radiation Research Society (RRS) and National Society for Immunotherapy of Cancer (SITC) Cancer Institute (NCI) Symposium: Symbiosis Symposium: Immune Biomarkers in Cancer of Radiation and Immunology: Basic and SUNDAY, MAY 10, 8:00 AM – 10:00 AM Translational Impact MONDAY, MAY 11, 8:00 AM – 10:00 AM Chairs: Lisa H. Butterfield, University of Pittsburgh Chairs: Augusto C. Ochoa, Louisiana State University Health Mansoor Ahmed, NCI, NIH Sciences Center Chandan Guha, Albert Einstein College of Medicine Speakers: Speakers: Augusto C. Ochoa, Louisiana State University Health Mansoor Ahmed, NCI, NIH Sciences Center Opening/meeting interaction Metabolism in the immune response to cancer Gayle E. Woloschak, Northwestern University Giorgio Trinchieri, NCI, NIH Introduction: Information on Radiation Research Society (RRS) Omics platforms and systems biology in biomarker identification Ralph R. Weichselbaum, University of Chicago Medicine Holden T. Maecker, Stanford University Medical Center Basic radiation biology: fatal attraction for immunologists High dimensional cellular and proteomic profiling approaches Yang-Xin Fu, University of Chicago Lisa H. Butterfield, University of Pittsburgh Immunologist’s experiences of collaborating with the field of Immune biomarkers in clinical trials radiation biology Chandan Guha, Albert Einstein College of Medicine Society for Leukocyte Biology (SLB) Symposium: Opportunities for immunology in clinical radiotherapy Society for Leukocyte Biology: The Next Generation Lisa M. Coussens, Oregon Health & Science University MONDAY, MAY 11, 10:15 AM – 12:15 PM Tumor immune microenvironment Chairs: Society for Glycobiology (SfG) Symposium: Louis B. Justement, University of Alabama at Birmingham Glycans and Immunity Silvia M. Uriarte, University of Louisville SUNDAY, MAY 10, 12:30 PM – 2:30 PM Speakers:

Chairs: Joshua J. Obar, Montana State University Leukotriene and IL-1alpha-mediated orchestration of the Brian A. Cobb, Case Western Reserve University School antifungal leukocyte response to Aspergillus fumigatus of Medicine I. Coy Allen, Virginia Polytechnic Institute and State University James P. Paulson, Scripps Research Institute Evaluating NLR modulation of canonical and non-canonical NF-KB signaling in IBD Speakers: Laura M. Sly, University of British Columbia Robert M. Anthony, Massachusetts General Hospital Harnessing macrophage phenotype for anti-inflammatory therapy Glycoregulation of immunoglobulins Madhavi J. Rane, University of Louisville Charles J. Dimitroff, Brigham and Women’s Hospital Baclofen, a GABA R agonist, ameliorates immune-complex- Galectin-1 binding glycans play a pleiotropic role in B mediated acute lung injury by modulating pro-inflammatory melanoma development mediators Eugene C. Butcher, Stanford School of Medicine Ilhem Messaoudi Powers, University of California, Riverside Carbohydrate addressins for lymphocyte homing Dose-dependent modulation of immune response to Paula A. Videira, NOVA Medical School vaccination by alcohol Immunomodulation of dendritic cells: cracking the role of sialic Silvia M. Uriarte, University of Louisville acid-containing sugars Neutrophils and oral pathogens: opposing forces in the Vijay K. Kuchroo, Brigham and Women’s Hospital dysbiosis battle Tim-3 and Galectin-9: regulators of effector and Treg cells

44 AAI Newsletter April 2015 GUEST SOCIETY SYMPOSIA

Society of Mucosal Immunology (SMI) Symposium: The Obesity Society (TOS) Symposium: Unique Lymphocyte Populations at Mucosal Immunometabolism of Aging Surfaces SUNDAY, MAY 10, 10:15 AM – 12:15 PM SUNDAY, MAY 10, 10:15 AM – 12:15 PM Chairs: Chairs: Barbara S. Nikolajczyk, Boston University School of Medicine Timothy L. Denning, Georgia State University Gerald V. Denis, Boston University School of Medicine Marielle C. Gold, Oregon Health & Science University Speakers: Speakers: Derek M. Huffman, Albert Einstein College of Medicine Ivaylo I. Ivanov, Columbia University Obesity, aging, and the intestinal stem cell niche Control of mucosal Th17 cell homeostasiss Daniela Frasca, University of Miami Florence Lambolez, La Jolla Institute for Allergy and Immunology Obesity, aging, and antibody responses + DN TCRĮǃ IEL: mix and match MHC reactivities Nathan K. LeBrasseur, Mayo Clinic Richard S. Blumberg, Harvard Medical School Cellular senescence: at the crossroads of aging, obesity, and exercise NKT cells orchestrate critical barrier protective functions in Shai Shen-Orr, Technion-Israeli Institute of Technology mucosal tissues Cellular immune response to chronic inflammation Marielle C. Gold, Oregon Health & Science University Simin N. Meydani, Tufts University Human pathogen-reactive MAIT cells Caloric restriction and immune function in aging humans

Society for Natural Immunity (SNI) Symposium: Advances in NK Cell Research SATURDAY, MAY 9, 10:15 AM – 12:15 PM

Chairs: Christine A. Biron, Brown University Eric O. Long, NIAID, NIH Speakers: Eric O. Long, NIAID, NIH Negative signaling by NK cell inhibitory receptors Sungjin Kim, Michigan State University Antibody-dependent memory-like NK cells Joseph C. Sun, Memorial Sloan Kettering Cancer Center Novel role for RAG in NK cells David K. Finlay, Trinity College Dublin Metabolic regulation of NK cell responses Emily M. Mace, Baylor College of Medicine The structure and function of the NK cell developmental synapse

www.aai.org AAI Newsletter 45 CAREER DEVELOPMENT SESSIONS

CAREER DEVELOPMENT SESSIONS Careers in Science Roundtable Sponsored by the AAI Education Committee & AAI Committee on the Through workshops, roundtables, and one-on-one Status of Women ™ counseling, IMMUNOLOGY 2015 provides critical SATURDAY, MAY 9, 11:30 AM – 1:00 PM career development programs. Career sessions and services this year include: Chair: • NIH Grants Workshop Virginia Shapiro, Mayo Clinic; AAI Committee on the Status of Women Chair • Careers in Biotech: Panel Discussion and Networking At this always popular session, you’ll have the opportunity to • Careers and Networking Roundtables (2) meet with scientists at your own career stage and with more • How to Convert Your CV into a Resumé (followed by one-on- experienced scientists to explore specific career issues important one consulting) to men and women in science today. Learn what others are • Interviewing for a Job thinking and gain insights into issues you are confronting in your own situation. Recently added topics offer insights into NIH study • Secrets for a Successful Postdoctoral Fellowship sections and considerations for scientists in M.D.-Ph.D. careers. AAI is also offering an online and onsite Jobs Board free to Choose from these and the other vital topics related to the meeting registrants and exhibitors. environment you work in (academic research, biotech industry, governmental agencies, non-profits), the transitions between NIH Grant Seminar Workshop: Demystifying the specific career stages, or issues in balancing career and family in any career path. Don’t miss this great networking opportunity! Application and Review Process Registration Fee: $20 (Lunch included.) SATURDAY, MAY 9, 8:00 AM – 10:00 AM Discussion topics: • Research Careers in Academia Chairs: • Graduate Student to Postdoc: finding a postdoc, Tina McIntyre, Scientific Review Officer, Innate Immunity and interviewing Inflammation Study Section, Immunology Integrated Review Group, Center for Scientific Review, NIH • Postdoc to PI: finding a position, interviewing, negotiating, lab start-up Alison Deckhut-Augustine, Chief, Basic Immunology Branch, Division of Allergy, Immunology, and Transplantation, • New PI: attracting students and postdocs, preparing NIAID, NIH for tenure

Additional Speakers: • Undergraduate Institutions: finding the balance in Nancy Vazquez-Maldonado, Scientific Review Officer, teaching, doing research Immunology Review Branch, NIAID, NIH • Mentoring Effectively Lakshmi Ramachandra, Scientific Review Officer, Immunology Review Branch, NIAID, NIH • How to Build a Network This workshop will provide participants with an overview of NIH • The Two Body Problem: dual career couples grant application, review, and management. Emphasis will be • Balancing Parenthood and Career given to identification of the most appropriate funding agency, how to make an application “reviewer friendly,” and other strategies • Careers in Biotech and Industry: moving from academia to that contribute to applications that succeed in obtaining research industry and vice versa funding. The workshop will also provide information on how to • Careers at Governmental Agencies (FDA/NIH/USDA/CDC) understand the peer review system, which is essential to competing successfully for funding, with a focus on recent changes to the • NIH Study Section Insights review process. NIH review, grants management, and program staff • Negotiating an Academic Position will provide a broad array of expertise and encourage questions • The Physician Scientist: balancing clinical and from seminar participants. This workshop is open to anyone but is research duties especially intended for new faculty members, young investigators, and advanced postdoctoral fellows. • Research from the M.D., Ph.D. Perspective • Non-research Careers for Scientists: careers in scientific journals, program administration, non-profits, industry

Table Leaders: See AAI Committee-sponsored Sessions

46 AAI Newsletter April 2015 CAREER DEVELOPMENT SESSIONS

Careers Roundtable and Speed Networking Session Discussion topics: Sponsored by the AAI Minority Affairs Committee • Grad Student: finding a mentor; taking aim at postdoc training Supported in part by a grant to the Federation of American Societies • Postdoc: finding a mentor; taking aim at a faculty position for Experimental Biology (FASEB) from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health • Junior Faculty: preparing for promotion and tenure [FASEB MARC Program: T36-GM08059-32] • Academia or Industry: how to decide (or switch sides) SATURDAY, MAY 9, 11:45 AM – 2:15 PM • Government Agency Careers: CDC, FDA, NIH • Non-research Careers (e.g., entrepreneurship, law/policy) Chair: Cherié L. Butts, Biogen Idec; AAI Minority Affairs Committee Chair Table Leaders: See AAI Committee-sponsored Sessions

Networking skills have never been more crucial to ensure success for early/mid-career scientists, including those traditionally under-represented in biomedical research. At the roundtable, take advantage of the opportunity to meet in small-group format with accomplished, senior immunologists to hear how they have handled the career challenges you now face and learn what they believe will work for you today. Then practice networking in a relaxed environment offering a structured networking exercise and personalized feedback on communicating your scientific interests/objectives most effectively. Registration Fee: $20 (Includes lunch; coffee/cookies during networking hour)

www.aai.org AAI Newsletter 47 CAREER DEVELOPMENT SESSIONS

Careers in Biotech: Panel Discussion of getting the most out of your postdoctoral fellowship, relating and Networking successfully with your mentor, and understanding how to use the resources available to you to ensure that your training prepares Sponsored by the AAI Education Committee you adequately for a seamless transition into the next phase of your career. SATURDAY, MAY 9, 7:00 PM – 9:00 PM

Chair: Interviewing for a Job Nandita Bose, Biothera MONDAY, MAY 11, 1:30 PM – 2:30 PM Panelists: Speaker: Jason Fontenot, Principal Scientist, Immunology, Biogen Idec Derek Haseltine, Director, Career Services, College of Professional Brian Johnson, Director, Market Development & Product Studies, George Washington University Management, Thermo Fisher Scientific This session will be focused on tips and techniques to help you Andy I. Kokaji, Senior Scientist, STEMCELL Technologies, Inc. successfully navigate the interview process. Emphasis will be on Isharat Yusuf, Research Investigator II, Genomics Institute of the how you can present yourself in the best possible light. You will Novartis Research Foundation also learn how to respond to unexpected questions. This session is open to anyone but is especially intended for students and Many opportunities exist in industry for scientists with advanced postdoctoral attendees. degrees. There are positions in laboratory research, program management, business development, regulatory affairs, clinical trials oversight, medical liaison, and more. This panel features scientists employed in a variety of positions in industry discussing their career VISIT THE AAI BOOTH (901) TO LEARN ABOUT AN paths and the skills required for success in each. Following the panel EXCITING NEW AAI CAREER DEVELOPMENT RESOURCE discussion, enjoy casual conversation with the speakers and other scientists from industry at a networking reception. THE CAREER ADVISORY BOARD (CAB)

How to Convert Your CV into a Resumé A Referral Service for connecting Young PIs with More Senior PIs for Advice on How to Manage Your First Lab! SUNDAY, MAY 10, 9:00 AM – 10:00 AM The CAB is Sponsored by the Committee on the Status Speaker: of Women but Is Open to All Junior Faculty in AAI. Derek Haseltine, Director, Career Services, College of Professional Studies, George Washington University For anyone seeking a job outside of academe, how you present yourself on paper is critical. A well prepared resumé can make all the difference in securing that interview. The focus of this session will be on the important elements of a resumé, the differences between a resumé and the standard academic curriculum vitae, and the information needed to make a good impression. In this special career development session, attendees will be instructed in how to transform their CVs into professional resumés. Small breakout sessions for individual consulting will follow from 10:30 AM to 12:30 PM. Bring your CV!

Secrets for a Successful Postdoctoral Fellowship MONDAY, MAY 11, 11:00 AM – 12:00 PM

Speaker: James Gould, Director, Office for Postdoctoral Fellows, Harvard Medical School A postdoctoral fellowship is the time to develop research skills you will need to succeed as an independent scientist. It is, however, just as important to realize that you need to prepare for a career path at the same time. This session will highlight ways

48 AAI Newsletter April 2015 IMMUNOLOGY 2015™ Annual Meeting of The American Association of Immunologists May 8–12, 2015 | Ernest N. Morial Convention Center | New Orleans, Louisiana

Jobs Board A Free Recruiting Service for Registrants and Exhibitors Post Online and Meet On-site AAI is offering career services to both job seekers and employers through a Jobs Board free to meeting registrants and exhibitors at www.immunology2015.org/jobs-board/index.html. Job Seekers! Whatever your career stage, use this career service at IMMUNOLOGY 2015™ to enhance your professional development!  Q Job Postings. Review the online AAI Jobs Board to identify postings you wish to pursue. (View new Advance Postings through April 29. Watch for On-site Postings, online or on paper in the Exhibit Hall!) Q Direct Access to Recruiters. Job postings will include recruiters’ e-mail addresses so that you can contact them directly.

Employers! Advertise your position on a virtual Jobs Board located on the IMMUNOLOGY 2015™ website. By including a contact email, you will receive inquiries directly. Q Advance Postings. Postings will be accepted as of February 2, 2015, and will remain online until the end of the meeting. To post job listings in advance of the meeting, contact [email protected]. Advance Postings must be submitted to AAI by April 29, 2015. Q On-site Postings. After April 29, 2015, employers wishing to advertise a job on the IMMUNOLOGY 2015™ website may still do so by visiting the AAI Office in the Ernest N. Morial Convention Center between 9:00 AM and 5:00 PM. You may also post a paper announcement on the bulletin board in the Exhibit Hall. Save Thousands of Dollars in Recruiting Expenses. Take advantage of this complimentary hiring opportunity at IMMUNOLOGY 2015™. To register for the meeting, visit www.immunology2015.org/registration.

The American Association of Immunologists, Inc. 9650 Rockville Pike | Bethesda, Maryland 20814 Phone: (301) 634-7178 | Fax: (301) 634-7887 Email: [email protected] | Web: www.aai.org

www.aai.org www.IMMUNOLOGY2015.org AAI Newsletter 49 POSTER SESSIONS & BLOCK SYMPOSIA

POSTER SESSIONS & BLOCK SYMPOSIA EXHIBITOR HALL PASSPORT PROGRAM Abstracts of unpublished, original research are presented during Poster Sessions and Block Symposia (oral presentations FILL OUT YOUR EXHIBIT HALL PASSPORT of poster data). This is perhaps the most dynamic aspect of FOR A CHANCE TO WIN ONE OF THREE the AAI annual meeting. Take part in face-to-face discussions with abstract authors and learn about their most recent, $250 AMERICAN EXPRESS GIFT CARDS! unpublished research. Poster Sessions will be held daily (unopposed by any other sessions) in the Exhibit Hall from Entries must be received by Monday, May 11, at 2:30 PM – 3:45 PM. 2:00 PM. The drawing will be held during the Poster Presentations on Monday, May 11 from 2:30 PM – 3:45 PM. You’ll find your Passport in your meeting bag or you may pick one up at the AAI Booth.

EXHIBITOR WORKSHOPS

Be sure to take advantage of the knowledge-building opportunities presented in Exhibitor Workshops. Located on the Exhibit Floor, these workshops explore companies’ latest technologies, products, and services through demonstrations and discussions. Workshops are planned and conducted by exhibitors; the listing of those workshops does not constitute endorsement of any products or services by AAI.

Visit the AAI History Exhibit

(FLOOR 1) A display featuring the diseases, institutions, and AAI members shaping immunology research in the greater New Orleans area.

50 AAI Newsletter April 2015 The American Association of Immunologists Gratefully Acknowledges the Generous Sponsorship of

for the IMMUNOLOGY 2015™ Opening Night Welcome Reception FRIDAY, MAY 8 • 6:00 PM – 8:00 PM

Chambers-eBioscience Memorial Award

Lustgarten-eBioscience Memorial Award

Meeting Bags

Program Support

IMMUNOLOGY 2015™

May 8 – 12 , 2015 • New Orleans, Louisiana • Ernest N. Morial Convention Center www.aai.org AAI Newsletter 51 AAI PROGRAM COMMITTEE | AAI ABSTRACT PROGRAMMING CHAIRS

2014–2015 AAI PROGRAM COMMITTEE

AAI gratefully acknowledges the efforts of the Program Committee for IMMUNOLOGY 2015™.

Wendy L. Havran, Chair Shane Crotty Paul Kubes The Scripps Research Institute La Jolla Institute for Allergy University of Calgary and Immunology Maria-Luisa Alegre Frances E. Lund University of Chicago James E. Crowe, Jr. University of Alabama at Birmingham Vanderbilt University Medical Center Marlene Bouvier David W. Pascual University of Illinois at Chicago Jennifer L. Gommerman University of Florida University of Toronto Daniel J. Campbell Erika L. Pearce Benaroya Research Institute Daniel H. Kaplan Washington University School of Medicine University of Minnesota

AAI ABSTRACT PROGRAMMING CHAIRS

AAI gratefully acknowledges the efforts of the Abstract Programming Chairs for IMMUNOLOGY 2015™. Antigen Processing and Immediate Hypersensitivity, Innate Immune Responses Transplantation Immunology Presentation Asthma, and Allergic and Host Defense: Molecular Donna L. Farber Malini Raghavan Responses Mechanisms Columbia University University of Michigan Paul J. Bryce Gregory M. Barton Medical Center Medical School Northwestern University University of California, Pavan Reddy Scheherazade Feinberg School of Medicine Berkeley University of Michigan Sadegh-Nasseri Toshiaki Kawakami Denise M. Monack Medical Center Johns Hopkins School La Jolla Institute for Allergy Stanford University of Medicine and Immunology Tumor Immunology Lymphocyte Differentiation Chrystal M. Paulos Basic Autoimmunity Immune Mechanisms of and Peripheral Maintenance Hollings Cancer Center Laura Mandik-Nayak Human Disease Nicole Baumgarth MUSC Lankenau Institute for Clara Abraham University of California, Davis Weiping Zou Medical Research Yale University Ross M. Kedl University of Michigan Chandra Mohan Marcus R. Clark University of Colorado, University of Houston University of Chicago Denver Vaccines and Immunotherapy Cellular Adhesion, Migration, Immune Response Microbial, Parasitic, and Lisa H. Butterfield and Inflammation Regulation: Cellular Fungal Immunology University of Pittsburgh Mechanisms Margaret S. Bynoe George S. Deepe Kohtaro Fujihashi Cornell University Andrew L. Mellor University of Cincinnati University of Alabama at College of Veterinary Medicine Georgia Regents University College of Medicine Birmingham Yoji Shimizu Thomas C. Mitchell Joanne Turner University of Minnesota University of Louisville Ohio State University Veterinary and Comparative Medical School School of Medicine Immunology Mucosal and Regional Cynthia L. Baldwin Cytokines and Chemokines Immune Response Immunology University of Massachusetts and Their Receptors Regulation: Molecular Peter B. Ernst Mechanisms Jeffrey A. Yoder Ninan Abraham University of California, College of Veterinary Medicine University of British Columbia Rachel M. Gerstein San Diego North Carolina State Mandy J. McGeachy University of Massachusetts Dana J. Philpott University University of Pittsburgh Medical School University of Toronto Mark H. Kaplan Viral Immunology Hematopoiesis and Immune Indiana University Therapeutic Approaches to Julia L. Hurwitz System Development School of Medicine Autoimmunity St. Jude Children’s Michael A. Farrar Jennifer H. Anolik Research Hospital Innate Immune Responses University of Minnesota University of Rochester Steven M. Varga and Host Defense: Cellular Medical Center University of Iowa Virginia M. Shapiro Mechanisms Mayo Clinic Olaf Stüve Judith Hellman University of Texas University of California, Southwestern Medical Center San Francisco Paige Lacy University of Alberta

52 AAI Newsletter April 2015 SCHEDULE OF BLOCK SYMPOSIA

FRIDAY, MAY 8 3:45 PM – 5:45 PM Antigen Processing and Presentation: Molecular Aspects 2:30 PM – 4:30 PM Innate Cells in Autoimmunity B Cells and Autoantibodies Leukocyte Migration: To Paths Less Traveled Cancer Immunotherapy and Mechanisms Regulatory Lymphocytes Cytotoxic Cells in Pathogen Immunity Signaling by Innate Receptors Mast Cells and IgE The Microbiota and Mucosal Immunity Microbial, Parasitic, and Fungal Immunology I Therapeutics in CNS Autoimmunity Molecular Regulation of Cytokine/Chemokine and Receptor Function MONDAY, MAY 11

SATURDAY, MAY 9 8:00 AM – 10:00 AM 8:00 AM – 10:00 AM Allergic Mechanisms II Novel Innate Immune Mechanisms Activation Mechanisms in Adaptive and Innate Immunity Respiratory Viruses and the Immune Response II Antigen Processing and Presentation: Cellular Aspects Veterinary and Comparative Immunology B Cell and Antibody Responses Induced by Vaccines Turning on the T Cell 10:15 AM – 12:15 PM 10:15 AM – 12:15 PM B Cell Development Epigenetics, Transcription, and Systems Biology of Conceptual Therapeutics in Autoimmunity Immune Responses Cytokine- and Chemokine-mediated Immunopathology Tregs and Cancer Immune Regulation Effector T Cell Regulation Molecular Decisions Controlling B Cell Activation and Outcomes 12:30 PM – 2:30 PM Novel Vaccines and Delivery Systems Cell Subsets, Cytokines and Inflammation Peripheral Lymphocyte Development, Homeostasis, and Aging Innate Sensing and Signaling in the Cytosol 12:30 PM – 2:30 PM Natural Killers, T Cells, and the Immune Response to Viral Infection Innate Immune Regulation New Cancer Vaccines Signaling Pathways in Autoimmune Responses Regulation of Immunity at the Lung Mucosa T Cell Regulation T Cells and Cytokines in Autoimmunity 3:45 PM – 5:45 PM 3:45 PM – 5:45 PM Lymphocyte Response Regulation and Memory Formation Advances in Transplantation Immunology Novel Therapeutic Approaches in Systemic and Inflammation: The Immune System in Action Organ Specific Autoimmunity Skin and Regional Mucosal Immunology T Cell Development T Cell Activation, Expansion, and Exhaustion T Cell Tumor Trafficking and Effector Function During Viral Infection Technological Innovations in Immunology

SUNDAY, MAY 10 TUESDAY, MAY 12 8:00 AM – 10:00 AM 8:00 AM – 10:00 AM Hematopoiesis Allergic Mechanisms I Innate Immune Responses to Pathogens Autoimmunity: Triggers and Regulation I Myeloid Cells and Tumor Mechanisms in T Helper Subset Fate Determination Regulation of CD4 T Cell Subset Differentiation Regulation at Mucosal Surfaces T Cell-Mediated Immune Responses and Protection Respiratory Viruses and the Immune Response I Following Vaccination 10:15 AM – 12:15 PM 10:15 AM – 12:15 PM Lymphocyte Activation and Differentiation Autoimmunity: Triggers and Regulation II Microbial, Parasitic, and Fungal Immunology II CARs, TCRs, and Adoptive Transfer for Cancer Tumorigenesis, Therapy, and Metastasis Immunoregulatory Functions of Cytokines Virus Infection and CD8+ T Cells Inflammation at the Intestinal Mucosa 12:30 PM – 2:30 PM Innate Immune Responses in Monocytes/Macrophages, Autoimmune and Inflammatory Diseases Dendritic Cells, and Myeloid Cells Cellular Innate Immune Responses to Pathogens Interplay of Viruses and the Innate Immune System Checkpoints and Combinations in Cancer Therapy Immune Regulation at the Intestinal Mucosa Thymic Microenvironment

www.aai.org AAI Newsletter 53 SOCIAL EVENTS

SOCIAL EVENTS

New Member Reception (By invitation only) Service Appreciation Reception (By invitation only) Sponsored by the AAI Membership Committee Generously sponsored by BioLegend FRIDAY, MAY 8, 4:00 PM – 4:45 PM SUNDAY, MAY 10, 7:30 PM – 9:30 PM (BADGE AND INVITATION REQUIRED) At this important event, AAI leadership honors the association’s AAI wishes to welcome new regular, associate, and postdoctoral dedicated member volunteers—the committee members, editors, members joining AAI for the first time. AAI President Linda mentors, instructors, and others—who work on the membership’s Sherman and other AAI leaders look forward to meeting you behalf throughout the year by giving generously of their time in personally. Please join us with your invitation in hand for light support of the AAI mission. Open by invitation to 2014-2015 refreshments and casual conversation. AAI volunteers.

Opening Night Reception: Carnival Night in NOLA IMMUNOLOGY 2015™ Gala: Lagniappe* on the Generously sponsored by eBioscience, an Affymetrix business Levee—The Tastes & Tunes of New Orleans Generously sponsored by BioLegend FRIDAY, MAY 8, 6:00 PM – 8:00 PM GREAT HALL LOBBY – MONDAY, MAY 11, 7:00 PM – 9:30 PM ERNEST N. MORIAL CONVENTION CENTER THE SUGAR MILL 900 CONVENTION CENTER BLVD. 1021 CONVENTION CENTER BLVD.

Pause during your week of intense science to enjoy an evening As you exit the President’s Address, you’ll be greeted by a with friends and colleagues at the AAI Gala: Lagniappe on the traditional southern Louisiana band in the Great Hall Lobby for Levee—The Tastes and Tunes of New Orleans. At this festive the Opening Night Welcome Reception. There you’ll sample the event to be held at the historic Sugar Mill directly across from many flavors of New Orleans cuisine, mingle with old friends and the Convention Center, you’ll enjoy sampling the ambience and revelers “borrowed” from Mardi Gras, and enjoy trying out your cuisines of three distinctive New Orleans neighborhoods—the Cajun two-step to the celebrated Dwayne Dopsie & Zydeco Vieux Carré, the Garden District, and Cajun Bayou Country. Hellraisers band. You’ll also be treated to the tunes of the 14-piece Swingaroux Band performing the many different genres of Louisiana music. And when you aren’t dancing, you’ll find lagniappe in novelty The Journal of Immunology (The JI) Editorial entertainment. Board Dinner and Meeting (By invitation only) *Lagniappe: a Creole expression pronounced [lay-nee-ap] and meaning “a Generously sponsored by Dartmouth Journal Services little something extra” SATURDAY, MAY 9, 7:00 PM – 10:00 PM

This working dinner is held each year at the annual meeting to provide Editorial Board members the valuable opportunity to meet in person to discuss items of interest and concern about The JI.

54 AAI Newsletter April 2015 The American Association of Immunologists Gratefully Acknowledges the Generous Sponsorship of

for the

IMMUNOLOGY 2015™ GALA MONDAY, MAY 11 • 7:00 PM – 9:30 PM

Service Appreciation Reception

Lefrançois-BioLegend Memorial Award

AAI-BioLegend Herzenberg Award

Meeting Lanyards

IMMUNOLOGY 2015™

May 8 – 12 , 2015 • New Orleans, Louisiana • Ernest N. Morial Convention Center www.aai.org AAI Newsletter 55 EXHIBITOR COMPANIES (AS OF MARCH 1, 2015)

AAI (The American Association of Essential Pharmaceuticals, LLC Oxford University Press Immunologists, Inc.) FASEB Maximizing Access to Research PBL Assay Science AAT Bioquest Inc Careers (MARC) – Gold Sponsor PEPperPRINT Abcam FiberCell Systems, Inc. PeproTech ACEA Biosciences, Inc. Fitzgerald Industries International PerkinElmer ACROBiosystems FlowJo (formerly Tree Star, Inc.) PharmaLegacy Laboratories (Shanghai) Adaptive Biotechnologies Corporation Fluidigm Corporation Co., Ltd. Advanced Targeting Systems Foxx Life Sciences ProImmune Limited AID Autoimmun Diagnostika GmbH Future Science Group PromoCell GmbH ALLCELLS Garland Science ProteinSimple Analytik Jena GenScript USA Inc. Proteintech Group Inc Ancell Corp GL Biochem (Shanghai) Ltd. Quidel Corporation Arbor Assays handyem Inc. Rainin Instrument, LLC Aviva Systems Biology Corporation Horizon Pharma, Inc. Randox Laboratories-US Ltd. Axis-Shield PoC Hycult Biotech RayBiotech, Inc. BD Biosciences – Silver Sponsor Illumina Inc. – Contributing Sponsor Research Diets, Inc. Beckman Coulter Life Sciences ImmPort: Immunology Database and Rockland Immunochemicals Bio X Cell – Contributing Sponsor Analysis Portal Sanofi Pasteur Biocompare Immudex USA SCIENION US, Inc. BioLegend – Platinum Sponsor Immune Epitope Database & SciMed Solutions Bio-Rad Laboratories – Contributing Sponsor Analysis Resource (IEDB) Seahorse Bioscience Biorbyt IMMUNOLOGY 2016™ Seattle Second Genome Bioss, Inc. Innova Biosciences Ltd Shenandoah Biotechnology, Inc. Bio-techne (formerly R & D Systems) IntelliCyt Corporation Sino Biological Inc. Boster Biological Technology International Congress of Immunology Society for Immunotherapy of Cancer (ICI) 2016 BrandTech Scientific, Inc. SomaLogic Inc InvivoGen British Society for Immunology Sony Biotechnology Inc. – iRepertoire, Inc. BTX / Harvard Apparatus Supporting Sponsor Jackson ImmunoResearch Laboratories, Inc. Bulldog Bio,Inc. SouthernBiotech JPT Peptide Technologies, GmbH CEDARLANE Springer LC Sciences Cell Press – Contributing Sponsor St. Jude Children’s Research Hospital LEINCO TECHNOLOGIES INC Cell Signaling Technology Stellar Biotechnologies Inc List Biological Laboratories Cellular Technology Limited STEMCELL Technologies Inc. – Bronze Logos Biosystems, Inc. Sponsor Chondrex, Inc. Lonza Stratedigm Cloud Clone Corp. Luminex Corporation Studylog Systems Cytek Development Mabtech, Inc. Taconic Biosciences Cytognos, S.L. MacVector, Inc. The Jackson Laboratory DartMouse MBL International Corporation The Scale People Inc. De Novo Software Mediso USA Thermo Fisher Scientific (Formerly Life eBioscience, an Affymetrix business – TechnologiesTM Platinum Sponsor Meso Scale Discovery ) – Silver Sponsor ECI 2015 – 4th European Congress of Miltenyi Biotec Tonbo Biosciences Immunology Mimotopes UVP LLC Elsevier B.V. Myriad RBM VDJServer EMD Millipore – Sustaining Sponsor Nature Publishing Group Worthington Biochemical Corp Enzo Life Sciences, Inc. Nexcelom Bioscience ZenBio, Inc. Equitech-Bio Inc. Norgen Biotek Corp. Essen BioScience – Contributing Sponsor Omni International

56 AAI Newsletter April 2015 EXHIBITOR WORKSHOPS

SATURDAY, MAY 9 for the purification of proteins and antibodies. In this system, purification resins constrained to the distal end of pipette tips are used in conjunction with the E4 XLS+ electronic pipette Accelerating Immunology Research with Simplified to generate protein samples of high purity and concentration. Multi-color Flow Cytometry on the Guava PureSpeed™ offers hands-free, semi-automated processing easyCyte™ Systems with pre-programmed and customizable protocols for different protein purification workflows. Multiple resin types are 10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 2 available for a variety of downstream applications—antibody EMD Millipore purification, immunoprecipitation, ion exchange, His-tagged affinity chromatography, and even peptide desalting—with Presenters: Katherine Gillis, Applications Scientist capacities ranging from the low hundreds of micrograms to tens of Complex interactions between host and pathogen targets require milligrams to accommodate small- and medium-scale purification modern immunology labs to have easy access to instruments needs. The PureSpeed™ system provides purified protein samples capable of multiplex analysis. Flow cytometers with the faster and at higher concentrations than competing technologies capacity for simultaneous measurement of sufficient targets for while offering the capability for higher throughput and increased immunological analysis have traditionally required extensive productivity for drug discovery applications. operator expertise and been housed in select or shared labs. With improvements to the Guava easyCyte™ flow cytometers, multi-color flow cytometry has never been more powerful and Using New Approaches to Investigate Human and accessible. The patented microcapillary fluidics used by all Guava Mouse Group 2 Innate Lymphoid Cell Responses systems uniquely enable absolute cell counts with small sample volumes in single-tube or 96-well plate format, rendering them 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 2 ideally suited for precious biological samples from patients or transgenic models. The Guava InCyte™ software provides an eBioscience, an Affymetrix business intuitive user interface that facilitates custom analysis while Presenters: Elia Tait Wojno, Ph.D., Assistant Professor, Cornell including templates for analysis of routine applications. Spectral University, Baker Institute for Animal Health compensation performed pre- or post-acquisition manually Group 2 innate lymphoid cells (ILC2s) are recently described or via automated wizard ensures confidence in precise multi- innate immune cells that contribute to type 2 inflammation, tissue parameter data. The heat-map view of high-throughput plate repair, and metabolic homeostasis in multiple tissues. Although results makes simultaneous visualization of multiple parameters ILC2s play key roles in various biological processes, these cells are possible, permitting assessment of multi-sample activation, rare, making analysis of their phenotype and function a technical synapse formation, and other immunomodulation in a single view. challenge. This session will discuss cutting-edge techniques that Data examples from the Guava easyCyte™ systems will be used to can be used to examine this dynamic cell population in murine demonstrate how up to 10 fluorophores can be accurately resolved models and in human tissues. A project focused on assessing the for multiplex and high-throughput experiments to advance role of the prostaglandin D2 receptor, chemoattractant homologous immunological investigations. molecule expressed by Th2 cells (CRTH2), in ILC2 responses will be used to highlight selected technical approaches and assays that can be used to analyze ILC2 phenotype and function. Techniques that Semi-automated, Small-scale Protein Purification will be highlighted include multi-color flow cytometry, cell-sorting and Sample Prep Using Rainin PureSpeed™ Tips approaches, single-cell RNA staining, and in vitro assays for ILC2 function. In particular, the PrimeFlow™ RNA assay, which enables 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 1 simultaneous assessment of protein and RNA transcript expression Rainin Instrument, LLC on a single-cell level, will be discussed. The key concepts described during the session will provide relevant information for those new Presenters: Thien Dinh, Field Application Specialist to the ILC field and for investigators who are already experienced in Low concentrations of purified protein present considerable issues the analysis of ILC responses. within drug development. Among these issues are diminishing yields due to loss of protein from vessel surface adhesion, denaturation, precipitation, and loss of activity. Additionally, tools such as structural analysis and many other assays, require high protein concentrations for accurate quantitation of reliable data. Traditional methods for concentrating protein samples such as centrifugation through a membrane filter can be time consuming and expensive and may likely result in loss of yield and activity. Here, we present an alternative way to generate high concentrations of protein with superior performance while increasing throughput and reducing processing time to decrease costs. Rainin Instrument has introduced the PureSpeed™ system www.aai.org AAI Newsletter 57 EXHIBITOR WORKSHOPS

Quantitate and Visualize Your Immune-cell MojoSort™, a Versatile Nanoparticle for Magnetic Functional Assays—a Live-cell Imaging Approach Isolation of Cells with High Purity, Yield, and Preserved Functionality 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 1 Essen BioScience 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 1 Presenters: Dan Appledorn, Ph.D., R&D Project Manager BioLegend Live-cell imaging is most commonly associated with adherent Presenters: Miguel Tam, Product Manager cell-based assays, but in this workshop, we will demonstrate how The isolation of a defined population from a complex mixture of a variety of immune cell functional assays can be performed using cells is a technical challenge that many researchers face on a daily the IncuCyte ZOOM™ in vitro imaging system and CellPlayer™ live- basis. Several strategies have been developed over the last decades, cell labeling reagents and the advantages such approaches offer including gradient centrifugation, fluorescent-activated cell sorting, over conventional ones. The assays exemplified include cytotoxic and magnetic-activated cell sorting. Magnetic labeling is the most immune cell killing of tumor cells, antibody-dependent cell- common and widely used approach, as it constitutes a fast, reliable, mediated cytotoxicity (ADCC), complement-dependent cytotoxicity and convenient method to obtain discrete populations with high (CDC), T cell proliferation, and T cell clustering. purity and yield, and the cells are readily available for downstream Common methods for measuring cell death and proliferation applications. Here, we present a new type of magnetic nanoparticles in immune cell assays include flow cytometry, chromium release, that may be used with current separation methods. To illustrate the and bioluminescent reporters. These methods come with certain ease and utility of the system, while maintaining functionality of the limitations (including the need to lift and process cells before isolated cells, bone marrow precursors were isolated from C57BL/6 measurements are made), may involve the use of radioactivity, mice using magnetic particles and characterized by flow cytometry. provide only indirect readouts, be end-point in nature, and provide The cells were then differentiated toward a macrophage-like no images of the biology under study. phenotype in vitro. After culture, the cells were stimulated with LPS and CpG, and the activated phenotype was compared with non- ™ Use of the IncuCyte ZOOM system, along with live-cell labeling stimulated cells. Surface markers analyzed include CD80, CD86, and reagents, allows cytotoxicity and proliferation assay readouts to be MHC II. The supernatant was collected and screened for the presence made directly from the assay plates within a standard incubator, of inflammatory cytokines, such as IFN- , GM-CSF, IL-1, and IL- requiring no handling or processing of cells or supernatants. 12, among others. The isolated cells show a differential activation Measurements are made repeatedly on the same wells, over the phenotype, as well as a defined cytokine profile, in accordance with entire assay time course, providing greater precision than time- the stimulation used when compared with non-stimulated cells. In course measurements obtained through a series of end-point this way, we establish the high-quality performance of BioLegend’s assays. In addition, the ability to create time-lapse movies from the new low-cost magnetic cell separation system. collected images allows visualization of cell–cell interactions, which can bring unique insights into the biology at hand.

Randox BIOCHIPS – Next Generation Microarrays

Higher Throughput Tissue Staining Using a Novel 1:45 PM – 2:30 PM EXHIBITOR WORKSHOP ROOM 2 Immunohistochemistry Method Randox Laboratories, Ltd. 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 2 Presenters: Rajneesh Mathur, National Manager, U.S., Randox EMD Millipore Laboratories, Ltd., MSc. Endocrinology, MBA Presenters: Michele Hatler, Product Manager BIOCHIP arrays offer innovative multiplexing of patient samples using 9x9 mm solid phase chips. Unlike most other multiplex or If you analyze protein expression in tissue samples using ELISA methods, BIOCHIPS do not require samples to be run in immunohistochemistry (IHC), you know that IHC can be time replicates. Off-the-shelf panels are available to cover biomarkers for consuming, laborious, and subject to process variability that affects cytokines, adhesion molecules, cerebral and metabolic syndrome. results. Attend this showcase to discover a unique, vacuum-driven Extensive custom panels can be created based upon the unique ® protein-detection system (SNAP i.d. 2.0) for conducting IHC faster research project requirements. The following cytokine arrays are than traditional methods but with reproducible staining. In this available: Cytokine Array I (IL-1a, IL-1b, IL-2, IL-4, IL-6, IL-8, IL-10, interactive session, you’ll see how precision vacuum manipulation EGF, IFN-g, MCP-I, TNF, VEGF)( available in high-sensitivity format, of IHC reagents minimizes slide handling while maintaining Cytokine Array II (IGF-I, RANTES, eotaxin, IL-I Ra, PDGF-BB, IP-10, consistency and avoiding tissue damage or signal artifacts. You’ll IL12-p40; Cytokine Array III (IL-5, IL-15, GM-CSF, MIP-Ia, TNFb: learn how to apply this technology to your archival fixed or Cytokine Array IV (MMP-9, sIL-2Ra, sIL-6R, sTNFRI, sTNFRII: fresh-frozen tissues for immunostaining or classical histological Cytokine Array V (IL-3, IL-7, IL-13, IL-I2p70, IL-23.) Cerebral protocols, such as hematoxylin and eosin, without needing an Arrays offered also include Cerebral Array I (BDNF, GFAP, H-FABP, ® expensive autostainer. The SNAP i.d. 2.0 platform processes up to IL-6) and Cerebral Array II (CRP, D-dimer, NSE, NGAL, sTNFRI, 24 slides and handles all blocking, washing, and incubation steps.

58 AAI Newsletter April 2015 EXHIBITOR WORKSHOPS

TM.) Available metabolic arrays: Metabolic Syndrome Array II antibody-binding theory and practice. Furthermore, best (adiponectin, CRP, Cystatin C,) and Metabolic Syndrome Array I practices in selecting antibodies and the need for multiple (C-peptide, ferritin, insulin, IL-1a, IL-6, leptin, PAI-1, resistin, TNF. validations, documentation, and commercial source partnerships Cardiac arrays include Cardiac Array Creatine-Kinase Muscle Brain will be discussed. (CK-MB) Heart-Type Fatty Acid Binding Protein (H-FABP), Troponin I (cTnI) and Cardiac Plus Array Carbonic Anhydrase III (CA III), Creatine-Kinase Muscle Brain (CK-MB), Glycogen Phosphorylase BB, (GP-BB), Heart-Type Fatty Acid Binding Protein (H-FABP), and The Characterization of Receptor Density on Troponin I (cTnI). Human Blood Cells

11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 1 BD Biosciences Presenters: Robert Balderas, VP, Market Development, BD Biosciences, and Peter Kruztzik, Ph.D., CEO, Primity Bio The lack of data describing the characterization of cell-surface antigen density, as well as the expression profiles of cell-surface molecules on the surface of terminally differentiated blood cells, has posed a number of challenges for use in the development of multi- color flow panel design. With the expansion of new colors and the development of flow cytometers with greater than 25 parameters, information on co-expression of receptors and receptor density will provide a much-needed parameter in flow cytometry. Today, we will focus on a study to enable a detailed characterization of receptor expression on multiple subsets of T cells, B cells, and non-T/B cell populations. This presentation will describe a technique for antigen SUNDAY, MAY 10 receptor characterization (QuantiBRITE™) and a study outline for the characterization of more than 400 surface antigens. Validating and Publishing with Antibodies: How to Increase Reproducibility and Avoid Reviewer Challenges LEGENDplex™: a More Consistent and Economical Multiplex Solution for Biomarker Assays 10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 1 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 2 EMD Millipore BioLegend Presenters: Chandra Mohan, Sr., Manager, Technical Writing & Documentation Development; Wayne Speckmann, Presenters: Shaoquan Ji, Head of ELISA and Multiplex Technologies R&D Manager; and Kevin Long, Manager, Technical Multiplex assays for measuring soluble targets are often associated Marketing and Content Development with three issues: (1) costly reagents and high-maintenance Antibodies are extremely valuable and ubiquitous tools in instruments; (2) inconsistent performance and data reproducibility; life science research, but in spite of their widespread use in and (3) time-consuming data analysis and reporting. To address immunoassays over the past several decades, there is still a lack these concerns, we developed a new multiplex bead-based assay of understanding of the design, validation, and appropriate system for simultaneous quantification of soluble markers using use of antibodies and controls to publish convincing science. standard, commonly available flow cytometers. We developed assay It is generally accepted that a good antibody must be specific panels for popular biomarkers (e.g., Th1, Th2, Th9, Th17, Th22, Tfh, and selective and should provide reproducible results in the inflammatory cytokines, interferons, and chemokines), as well as context for which it is used. The large diversity of antibody novel biomarkers for immunology and other biomedical research users, their background and experience, and their large range fields. Our multiplex assay kits are a great value in all three formats: of applications, coupled with hundreds of commercial sources pre-defined panels, mix-and-match panels, and customized panels. for antibodies and immunotechnologies, make understanding For those who develop their own multiplex assays, our functional antibody theory and use very relevant today. This presentation polystyrene beads are also available. To accommodate needs for will discuss several key aspects of antibody design, validation, and different laboratory settings, flexible assay protocols are provided best practices for publishing on various applications, from basic for use with microtiter filter plates, test tubes, or standard U- or immunopurifications and Western blots to conformation-specific V-shaped microtiter plates. The reagents used in our assay kits are binding and high-speed imaging flow cytometry. Typical reviewer well published and were carefully selected for analytical specificity, comments will be addressed and discussed in the context of sensitivity, accuracy, and reproducibility. The assay panels were

www.aai.org AAI Newsletter 59 EXHIBITOR WORKSHOPS

validated using biologically relevant samples, which were tested Comparison of High-Performance and Budget- under pre-defined conditions, and expected biological changes Friendly Flow Cytometers Using Esoteric Cell were detected, as published. Compared with similar assay Analysis products on the market, LEGENDplex™ assays provide equal or better analytical performance, reduced cost, and greater 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 1 consistency and flexibility. To facilitate data analysis on different flow cytometers (FCS 2.0, 3.0, 3.1, and list mode files), a software ACEA Biosciences, Inc. package with an intuitive interface, accurate curve-fitting, and Presenters: Ryan Duggan, Technical Director Flow Cytometer robust reporting was specifically developed and is offered free Core Facility, University of Chicago, and of charge to LEGENDplex™ kit users. Together, our multiplex Garret Guenther, Ph.D., Application Scientist assay kits and software offer a better and more economical Traditional methods, using the side-population analysis to identify solution for simultaneous quantification or qualitative analysis stem cells, involve the use of a flow cytometer with an ultraviolet of multiple soluble biomarkers from serum, plasma, cell-culture laser-excited dye. These methods present some cost challenges supernatant, and other sample types. for researchers. Even though other violet dyes, such as DyeCycle Violet (DCV), which uses the more economical violet laser, are now available, the cost of a flow cytometer to provide this type The Well-Versed Immunologist: How to Integrate of analysis is still an obstacle. More recently, new benchtop flow cytometers have become available that can provide the quality of the Immunological Genome Project in Your a high-end flow cytometer at a much more affordable cost. In this Research analysis, we sought to identify stem cells and progenitors using the side-population technique in murine bone marrow. We used 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 1 ACEA Biosciences’ NovoCyte flow cytometer, which maximizes eBioscience, an Affymetrix business optical design through its use of shared PMTs. To conduct the side-population analysis, we stained bone marrow samples Presenters: Gwendalyn J. Randolph, Ph.D., Professor, Pathology with DCV-conjugated antibodies for lineage markers, Sca-1, and and Immunology, Washington University in St. Louis c-kit. Using a gating sequence to define lineage-Sca-1+c-kit+ cells This workshop will introduce the attendee to the Immunological combined with back-gating strategies, we were able to confirm the Genome Project and provide an overview of its goals, highlights of correct identification of stem cells. The use of this budget-friendly data outcomes, and current endeavors. Examples will include the cytometer allows researchers with limited resources to conduct impact of the project on macrophage biology. Finally, the workshop complex analyses and generate quality data. will illustrate how to use the online resources of the Immunological Genome Project to avail your ongoing research.

Advances in Immune Repertoire Profiling Using the immunoSEQ™ Assay Tools for the Study of ILC2 Regulation During Lung Inflammation 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 2

12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 2 Adaptive Biotechnologies Corp. Presenters: Catherine M. Sanders, Director, Scientific Liaison STEMCELL Technologies Adaptive Biotechnologies’ commercial products combine the Presenters: Grace F.T. Poon, Ph.D, and Itziar Martinez-Gonzalez, capabilities of bias-controlled multiplex PCR, high-throughput Ph.D, Postdoctoral Fellows, Department of Pathology sequencing, and a bioinformatics pipeline to profile T and B and Laboratory Medicine, University of British cell receptors (TCRs and BCRs). This cutting-edge capability is Columbia complemented by powerful software tools that facilitate analysis, Group 2 innate lymphoid cells (ILC2s) are a relatively new subset visualization, and comparison of TCR or BCR sequence data. of cells that have been implicated in allergic lung inflammation. Adaptive Biotechnologies’ immunoSEQ™ assay is applicable STEMCELL Technologies provides cell isolation products, in various fields, including autoimmunity, infectious disease, specialized cell culture media, and supporting reagents for ILC2 vaccine development, allergy, oncology, drug development, and research. Workshop highlights include breakthrough results from transplantation. The power of the immunoSEQ™ assay is now two ILC2 studies, featuring optimized methods for the study of available as a service and a research use-only kit. Come and learn ILC2s using products by STEMCELL Technologies. These studies how the immunoSEQ™ assay can be applied to your research. describe the LPS mediated negative regulation of ILC2s and the ability of allergen-experienced ILC2s to display memory-like functions.

60 AAI Newsletter April 2015 EXHIBITOR WORKSHOPS

MONDAY, MAY 11 Recent Work & Current Methods in Immunology MicroRNA Research Variables in FBS Impact Cell Performance, 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 1 Reproducibility and Relevant Experimental Results LC Sciences/Norgen Biotek 10:00 AM – 10:45 AM EXHIBITOR WORKSHOP ROOM 1 Presenters: Christoph Eicken, Ph.D., Head of Technical Services, LC Essential Pharmaceuticals, LLC Sciences, and Moemen Abdalla, Ph.D., Senior Scientist, Norgen Biotek Presenters: Adam Elhofy, Ph.D., CSO, Essential Pharmaceuticals, LLC MicroRNAs have proven to be an extremely important part of the Fetal bovine serum (FBS) has been used in cell culture for gene expression regulation mechanism. While the role of microRNAs decades. Even though it introduces the greatest variability in cancer was recognized early on, expression profiling and functional into cell culture, surprisingly FBS is not intensely scrutinized studies have now shown that microRNAs participate in the regulation as a reagent. The use of FBS in cell culture applications will of many biological systems. There is now strong evidence suggesting be examined, as its use may go against the basic principles of that microRNA signaling plays a significant role in both innate scientific experimentation in that the variables are not controlled and adaptive immune , and their dysregulation contributes to for, it contains unknowns, and results from experiments using pathogenesis. This workshop, presented by LC Sciences and Norgen FBS in cell culture potentially cannot be replicated. Biotek, will focus on the recent developments of microRNA research in the field of immunology and current methods for microRNA isolation and profiling: a brief review of microRNA basics, including Cytokine Assay Tips from the Experts: Why Just history, biogenesis, and function, as well as case studies and application examples. Multiplex When You Can MILLIPLEX®

10:00 AM - 10:45 AM EXHIBITOR WORKSHOP ROOM 2 EMD Millipore Beyond Coincidence: Analyzing Individual Presenters: Mike Vaughn, Multiplex and Cytometry Specialist, and Exosomes with Flow Cytometry Debra MacIvor, Product Manager 11:15 AM - 12:00 PM EXHIBITOR WORKSHOP ROOM 2 Low levels of chronic inflammation, marked by subtle changes Bio-Techne (formerly R&D Systems) in many cytokines, are involved in many clinical and sub-clinical disease states, such as autoimmune disease, cardiovascular Presenter: Tom Maslanik, Ph.D., Product Manager, Immunology disease, diabetes, neurological disorders, and cancer. Measuring and Flow Cytometry picogram levels of cytokines in multiplex, therefore, is critical for Current methods for interrogating small particles, such as exosomes, understanding the pathogenesis of these diseases. At this workshop, measure either averages from mixed populations of particles or you can participate in an interactive “dry run” demonstration of are non-quantitative. Unfortunately, these approaches potentially ® how to use the MILLIPLEX multi-analyte panel (MAP) human mask differences in mixed populations of vesicles or produce high-sensitivity T cell panel to detect low levels of as many as 21 non-representative data. With the use of a modified flow cytometer ® cytokines and chemokines simultaneously, using a Luminex adapted for small-particle analysis by John Nolan at the Scintillon ® MAGPIX instrument. If you are unfamiliar with the technology, you Institute, we were able to label and separately detect over 10 analytes ® will walk away with an idea of how the Luminex technology and on individual exosomes. These analytes included general exosomal ® MILLIPLEX MAP multiplex panels enable you to investigate the markers, such as CD9 and CD63, markers of tissue or cell of origin, modulation and expression of dozens of analytes simultaneously and several immunological signaling molecules. The data generated with speed and sensitivity, dramatically improving productivity. demonstrate the feasibility of this approach to support future If you are proficient with the technology, our specialist will be characterization of heterogenous groups of exosomes or other small providing valuable tips, ranging from sample collection and vesicles. This research should provide a deeper understanding of the preparation of reagents to the immunoassay procedure, advice for diverse population of vesicles that are emerging as key factors in a reducing variability, and best practices around data acquisition and number of widely studied physiological and pathological processes. analysis. These tips and more can be found in our new technical guide, entitled “The Power of Biomarker Analysis,” a copy of which will be given to each of our workshop attendees.

www.aai.org AAI Newsletter 61 EXHIBITOR WORKSHOPS

Integrated Protein Analysis Techniques Toward the Ultimate Diagnostics: Next-Generation Sequencing (NGS) of the Immune Repertoire for 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 1 Biomarker Discovery Thermo Fisher Scientific 1:45 PM - 2:30 PM EXHIBITOR WORKSHOP ROOM 1 Presenters: David Bourdon, Ph.D., Staff Scientist iRepertoire, Inc. Greater understanding of immunological processes necessitates knowledge of both the presence and level of proteins in cells, Presenters: Jian Han, CEO tissues, and fluids in the models we study. Join us for a presentation In this seminar, learn how to perform immune repertoire on various techniques for detection and quantitation of specific amplification using a proprietary multiplex PCR method. Our target proteins in biological samples. We will discuss the relative streamlined process is inclusive, semi-quantitative, and easy to use. merits of microscopy, Western blot, flow cytometry, ELISA, You can use a regular PCR machine or use the iCubate platform for ® Luminex multiplex assays, and more, as well as when it may be automated library prep. From a typical peripheral blood sample, appropriate to choose one technique over another. you will obtain 100,000–300,000 unique CDR3 sequences. Amplified libraries are pooled and submitted for NGS using either the Illumina or Roche 454 platform. Up to 60 samples can be pooled for one sequencing run to reduce cost. We have established an online data Imaging Flow Cytometry: the Benefits of analysis pipeline that applies stringent filters to remove errors and Combining Microscopy and Flow Cytometry in One provides many different types of analyses free of charge. As part of the Platform seminar, we will also discuss the non-profit initiative, Repertoire 10K (R10K), which aims to study the immune repertoire of 100 different 12:30 PM - 1:15 PM EXHIBITOR WORKSHOP ROOM 2 diseases. We have developed two key indexes to describe the immune EMD Millipore repertoire, i.e., the diversity index (or D50) and sharing index. These indexes allow us to identify disease-specific signatures for diagnosis, Presenters: Sherree Friend, Ph.D., Applications Scientist prognosis, and treatment guidance. Please join us to learn more! Imaging flow cytometry combines the speed, sensitivity, phenotyping capabilities, and statistical power of flow cytometry with the detailed imagery and functional insights of microscopy. The features and benefits of the Amnis® brand ImageStream®X and FlowSight® imaging flow cytometers will be explored. Quantitative image analysis and greater fluorescence sensitivity amplify research potential beyond the traditional flow cytometer or microscope alone. New publications and applications in immunology will be discussed.

AAI STORYBOOTH

VISIT THE STORYBOOTH (ROOM 223)

Visit the AAI StoryBooth with friends, colleagues, and/or mentors to record your stories and become part of AAI history.

StoryBooth Schedule at IMMUNOLOGY 2015™:

Saturday, Sunday, and Monday - May 9 - 11 9:00 AM – 12:00 PM and 1:00 PM - 5:00 PM

62 AAI Newsletter April 2015 AAI EARLY/MID-CAREER ACHIEVEMENT AWARDS

2015 AAI EARLY/MID-CAREER ACHIEVEMENT AWARDS

Pfizer-Showell Travel Award Kenneth J. Oestreich, Ph.D. Assistant Professor Virginia Tech Carilion Research Institute Lefrançois-BioLegend Memorial Award Taylor J. Feehley Graduate Student University of Chicago Chambers-eBioscience Memorial Award Andrew Zloza, M.D., Ph.D. Assistant Professor Rutgers Robert Wood Johnson Medical School Lustgarten-eBioscience Memorial Award Xingxing Zang, M.Med., Ph.D. Associate Professor Albert Einstein College of Medicine

AAI-Thermo Fisher Trainee Achievement Awards

Aimee M. Beaulieu, Ph.D. Lindsey E. Padgett Postdoctoral Fellow Graduate Student Memorial Sloan Kettering University of Alabama, Birmingham Cancer Center Amy V. Paschall Michael Jeffrey Cho Graduate Student Graduate Student Georgia Regents University University of Pennsylvania Pablo A. Penaloza-MacMaster, Ph.D. David J. DiLillo, Ph.D. Postdoctoral Fellow Beth Israel Deaconess Medical Center, Postdoctoral Fellow Harvard Medical School Rockefeller University

www.aai.org AAI Newsletter 63 2015 Introductory Course in Immunology July 14–19, 2015 • Long Beach Convention Center, Long Beach, California Director: Juan Carlos Zuñiga-Pflücker, Ph.D. University of Toronto and Sunnybrook Research Institute

Don’t miss the most comprehensive introduction to immunology available! This intensive two-part course, taught by world-renowned immunologists, provides a comprehensive overview of the basics of immunology. This course is for students new to the discipline or those seeking more information to complement general biology or science training. Part I (July 14–16) is a detailed introduction to the basic principles of immunology and is suitable for students with a general biology background. Part II (July 17–19) is a clinically oriented lecture series focusing on specialty areas. Parts I and II may be taken independently at the discretion of the student. Faculty Juan Carlos Zuñiga-Pflücker, University of Toronto Ninan Abraham, University of British Columbia and Sunnybrook Research Institute Cytokines Introduction to the Immune System Megan K. Levings, University of British Columbia Lewis L. Lanier, University of California, San Francisco T and B Cell Tolerance Innate Immunity: Introduction to the Cells Matthias G. von Herrath, La Jolla Institute for Allergy Andrea J. Tenner, University of California, Irvine and Immunology Complement Autoimmunity Jessica A. Hamerman, Benaroya Research Institute Olivia M. Martinez, Stanford University School Innate Immunity: Introduction to Pattern of Medicine Recognition and Intracellular Signaling Transplantation Wendy L. Havran, The Scripps Research Institute Peter B. Ernst, University of California, San Diego Introduction to Adaptive Immunity Mucosal Immunology Nilabh Shastri, University of California, Berkeley Steven F. Ziegler, Benaroya Research Institute Antigen Processing and Presentation Type 2 Immunity Juan Carlos Zuñiga-Pflücker, University of Toronto Linda A. Sherman, The Scripps Research Institute and Sunnybrook Research Institute Tumor Immunology MHC Restriction and Thymic Selection Robert L. Modlin, University of California, Los Angeles David Nemazee, The Scripps Research Institute David Geffen School of Medicine B Cell Development and Maturation Immunity to Bacterial Pathogens Shannon J. Turley, Genentech, Inc. Steven M. Varga, University of Iowa Dendritic Cells: The Bridge Between Innate Immunity to Viruses and Adaptive Immunity Michael J. Bevan, University of Washington Michael Croft, La Jolla Institute for Allergy Immunologic Memory and Immunology Nicole Frahm, Fred Hutchinson Cancer Research Center Effector T Cell Differentiation and Response Vaccination Shane Crotty, La Jolla Institute for Allergy Donald B. Kohn, University of California, Los Angeles and Immunology Genetic Approaches to Immune-Mediated Diseases B Cell Activation and Humoral Immunity Andrew C. Chan, Genentech, Inc. Arthur Weiss, University of California, San Francisco Bench to Bedside to Bench: Current Issues Signaling in the Immune System in Immunology Stephen M. Hedrick, University of California, San Diego Immune Homeostasis in Infection and Disease

For complete course details and registration, visit: www.aai.org/Education/Courses For assistance, contact (301) 634-7178 or [email protected]. Overseas applicants are advised to apply early for visas; for details, visit www.aai.org/Education/Courses/Visa.html. 64 AAI Newsletter April 2015 2015 AAI TRAINEE ABSTRACT AWARDEES

Awarded to AAI Trainee Members (students and postdoctoral fellows) whose first-author abstracts are selected for presentation in AAI Block Symposia. Award amounts vary according to recipient’s years of consecutive membership.

Support, in part, for these awards has been generously provided by BD Biosciences.

THIRD-YEAR (OR LONGER) Waleed Abdel Wahab Elsegeiny Ribhu Nayar Melissa Yuwono Tjota MEMBERS Children’s Hospital of Pittsburgh of University of Massachusetts Medical University of Chicago UPMC School Ephraim Abrokwa Ansa-Addo, Kevin Wayne Tosh Ph.D. Timothy Erick Steven C. Neier NIH Georgetown Graduate Medical University of South Carolina Brown University Mayo Clinic Graduate School Partnership Program Emily J. Anstadt Heather Leigh Evans-Marin Ryan W. Nelson, Ph.D. Stina Lisa Urban University of Connecticut Health University of Texas Medical Branch University of Minnesota Medical University of Massachusetts Medical School School Center Kellsye Paula Fabian Todd Bartkowiak University of Pittsburgh Amber M. Papillion Adam Utley SUNY Upstate Medical University Roswell Park Cancer Institute University of Texas M.D. Anderson Leonardo Ferreira Cancer Center Harvard University Katherine H. Parker Alexander J. Vogel University of Maryland, Baltimore University of Nebraska, Lincoln Nicole Elizabeth Behrens Daniel Frederick University of California, Davis Tulane University Yfke Pasman Masashi Watanabe, Ph.D. University of Guelph NCI, NIH Anna Kathleen Bird Mohamed Ahmed Ghonim University of Rochester Louisiana State University School of Pablo A. Penaloza-MacMaster, Ph.D. Marie Wehenkel, Ph.D. Katharine E. Block Medicine Beth Israel Deaconess Medical St. Jude Children’s Research Hospital Center, Harvard Medical School University of Chicago Hannah Priyadarshini Gideon, Ph.D. Jing Wen Rachel Bonami, Ph.D. University of Pittsburgh School of Peter Pioli Albert Einstein College of Medicine Medicine University of Utah Vanderbilt University Sonja Petra Zahner, Ph.D. Yihua Cai, Ph.D. Yanxia Guo Dalia Raich-Regue, Ph.D. La Jolla Institute for Allergy and University of Louisville Merck Research Laboratories University of Pittsburgh Immunology Florent Carrette, Ph.D. Prajwal Gurung, Ph.D. Pragya Rampuria Yusi Zhang Sanford-Burnham Medical Research St. Jude Children’s Research Hospital University of Oklahoma Health Fourth Military Medical University Sciences Center Institute Si-Han V. Hai Zemin Zhou Chih-Hao Chang, Ph.D. University of California, San Francisco Justin Richner, Ph.D. University of Utah Washington University in St Louis Washington University School of Matthew Halpert, Ph.D. Medicine Baylor College of Medicine Jordy Saravia, Ph.D. SECOND-YEAR MEMBERS Seung-Chul Choi, Ph.D. University of Tennessee Health Daehee Han, Ph.D. Elisabeth B. Adkins University of Florida Science Center Institute for Basic Science, Pohang Jackson Laboratory Allison F. Christiaansen University of Science and Technology Gail D. Sckisel, Ph.D. Courtney K. Anderson University of Iowa University of California, Davis Tarsha L. Harris Brown University Jo Erika Narciso Ciccotelli St. Jude Children’s Research Hospital Abigail L. Sedlacek, Ph.D. Stefanie R. Bailey University of Pittsburgh University of Pittsburgh Fan-Chi Hsu, Ph.D. Medical University of South Carolina Derek Clouthier Mayo Clinic Mary E. Severin Eugene J. Becker, Jr. University of Toronto Ohio State University Yinghong Hu University of Alabama, Birmingham Sara L. Colpitts, Ph.D. University of Connecticut Health Tiffany Shih Parna Bhattacharya, Ph.D. University of Connecticut Center Rutgers University U.S. Food and Drug Administration Vinh A. Dao Pravin Kesarwani, Ph.D. Sharad Shrestha Daniel F. Camacho University of Texas Health Science Medical University of South Carolina St. Jude Children’s Research Hospital/University of Tennessee University of Chicago Center San Antonio Nandini Krishnamoorthy, Ph.D. Health Science Center Samantha A. Chalmers Alok Das Mohapatra, Ph.D. Harvard University Nianbin Song Albert Einstein College of Medicine University of Connecticut Health Jen-Feng Lai, Ph.D. Johns Hopkins University Center Benaroya Research Institute Shilpak Chatterjee, Ph.D. Margarite L. Tarrio Medical University of South Carolina David J. DiLillo, Ph.D. Sharline Madera Brown University Rockefeller University Weill Cornell/Rockefeller/Sloan Nicholas M. Chesarino Ohio State University Susu Duan, Ph.D. Kettering Tri-Institutional Erin Taylor University of Mississippi Medical St. Jude Children’s Research Hospital Sean Ryan McMaster Zinal S. Chheda Center University of Louisville Jarrod A. Dudakov, Ph.D. Emory University Roberto Tinoco, Ph.D. Memorial Sloan Kettering Cancer Jonathan P. McNally, Ph.D. Ameet A. Chimote, Ph.D. Sanford-Burnham Medical Research Center Cincinnati Children’s Hospital University of Cincinnati Institute Allison Ehrlich, Ph.D. Oregon State University

www.aai.org AAI Newsletter 65 2015 AAI TRAINEE ABSTRACT AWARDEES

Hyoung-Soo Cho Rajendra Karki, Ph.D. Senthilkumar Palaniyandi, Ph.D. Junmei Wang, Ph.D. University of Massachusetts Medical St. Jude Children’s Research Hospital University of Maryland University of Texas MD Anderson School Cancer Center Domenick Edward Kennedy Michael S. Papadimitrious Michael Jeffrey Cho Loyola University Chicago University of Sydney Aliyah M. Weinstein University of Pennsylvania University of Pittsburgh Eunsoo Kim Sandeep Pawar, Ph.D. Kiera Clayton Ohio State University University of Chicago Alexandra R. Witter University of Toronto University of North Texas Health Sarah R. Klein, Ph.D. Kyle K. Payne Science Center Michael G. Constantinides, Ph.D. Dana-Farber Cancer Institute Virginia Commonwealth University NIAID, NIH Jie Xu, Ph.D. Priscilla Lee Mallory L. Paynich University of Pennsylvania Laura M. Davison Ohio State University Loyola University Chicago Cleveland Clinic Foundation Soo Jung Yang, Ph.D. Kun-Po Li Rhiannon Penkert, Ph.D. University of California, Berkeley Carina Anja Dehner Cincinnati Children’s Hospital Medical St. Jude Children’s Research Hospital Institute of Immunobiology, Yale Center Chen Yao Rachael Laura Philips School of Medicine University of Minnesota Siqi Liu Mayo Clinic Pritesh Desai Duke University Xiaomei Yuan, Ph.D. Kritika Ramani University of Florida University of California, San Diego Zheng Lou, Ph.D. University of Pittsburgh Daniel F. DiToro University of Texas Health Science Nikolaos Zacharakis, Ph.D. Kristen M. Reeder University of Alabama, Birmingham Center San Antonio Old Dominion University University of Alabama, Birmingham Katherine Doll Christopher R. Lupfer, Ph.D. Melody Yue Zeng Allison E. Reeme University of Iowa St. Jude Children’s Research Hospital University of Michigan Medical College of Wisconsin Daniel F. Dwyer Hadi Maazi, D.V.M., Ph.D. Baojun Zhang, Ph.D. Divya Sagar Brigham and Women’s Hospital University of Southern California Duke University Drexel University College of Medicine Patrick Falahee Christian J. Maine, Ph.D. Yongliang Zhang, Ph.D. Ankit Saxena, Ph.D. University of California, Davis Scripps Research Institute Medical University of South Carolina Johns Hopkins Medical Institute Andrew P. Ferretti Hadijat M. Makinde Robert P. Sheehan, Jr. University of South Alabama Rush University Medical Center University of Pittsburgh Michael L. Freeman, Ph.D. Ankit Malik FIRST-YEAR MEMBERS Boyoung Shin Case Western Reserve University St. Jude Children's Research Hospital University of Alabama, Birmingham Jeonghyun Ahn, Ph.D. Yoichi Furuya, Ph.D. Silvio Manfredo Vieira, Ph.D. University of Miami Maninder Sidhu, Ph.D. Albany Medical College Yale University Cedars-Sinai Medical Center Sabrin H. Albeituni Jaleesa M. Garth Sarah M. McCormick, Ph.D. University of Louisville Nandini Singarapu, Ph.D. University of Alabama, Birmingham Johns Hopkins University University of Texas MD Anderson Maha A. Almanan, M.D. Jie Geng, Ph.D. Rabinarayan Mishra, Ph.D. Cancer Center Cincinnati Children's Hospital University of Michigan University of Massachusetts Medical Mark Dharam Singh, Ph.D. Saravanan Andalur Nandagopal, School Sara Gibson Benaroya Research Institute Ph.D. University of Alabama, Birmingham Payal Mittal, Ph.D. University of Manitoba Carolyne K. Smith University of Connecticut Health Jacqueline J. Glascock, Ph.D. University of Michigan Christopher S. Anderson Center University of Missouri University of Rochester Anthony J. St. Leger, Ph.D. Maximillion Tobias Mize Chunqing Guo, Ph.D. NEI, NIH Kevin Barry University of North Texas Health Virginia Commonwealth University University of California, Berkeley Science Center Roslyn Ann Taylor Jennie A. Hamilton Yale School of Medicine Aimee M. Beaulieu, Ph.D. Eslam Mohamed University of Alabama, Birmingham Memorial Sloan Kettering Cancer Georgia Regents University Mia Farrah Tazi Center William F. Hawse, Ph.D. Ohio State University Crystal Morales, Ph.D. University of PIttsburgh Breanna Laine Breaux University of Connecticut Health Alexander Tong Texas A&M University Kirsten M. Hooper Center Case Western Reserve University Temple University Cory Alexander Brennick Giora I. Morozov, M.D., Ph.D. Te-Chen Tzeng, Ph.D. University of Connecticut Health Center Cara L. Hrusch, Ph.D. NIAID, NIH University of Massachusetts Medical University of Chicago School Julie G. Burel, M.D. Hadeil Abdalla Morsi, M.B.B.S. QIMR Berghofer Medical Research Zicheng Hu Southend University Hospital Anita van der Zwan Institute University of Texas, Austin Harvard University Trang T. Nguyen Amanda Rae Burmeister Matthew Hufford, Ph.D. University of California, Davis Arthur James VanValkenburg University of North Carolina, Charlotte Indiana University School of Medicine University of Alabama, Birmingham Rebecca J. Nusbaum Leandro J. Carreno, Ph.D. Jill A. Ippolito University of Texas Medical Branch Enrico Velardi, Ph.D. Albert Einstein College of Medicine Loyola University Chicago Memorial Sloan Kettering Cancer Claire E. O’Leary Center Kyle J. Caution, Ph.D. Shannon M. Kahan, Ph.D. University of Pennsylvania Ohio State University University of Alabama, Birmingham Pedro M. Vieira, Ph.D. Lindsey E. Padgett Harvard Medical School Nagarjuna R. Cheemarla University of Alabama, Birmingham Louisiana State University

66 AAI Newsletter April 2015 2015 AAI TRAINEE ABSTRACT AWARDEES

Feidi Chen, M.D. Theresa Geiger Abirami Kugadas, D.V.M., Ph.D. Katherine Nutsch University of Texas Medical Branch Memorial Sloan Kettering Cancer Center Brigham and Women’s Hospital, Washington University in St. Louis Harvard Medical School Liang Chen Abby L. Geis Jesus Alejandro Ocana Duke University Johns Hopkins School of Medicine Almin Lalani Indiana University School of Medicine Rutgers University Min-Min Chen Emily Lauren Goldberg, Ph.D. Thomas Howard Oguin, III Sun Yat-sen University Yale University Pedro A. Lamothe St. Jude Children’s Research Hospital Ragon Institute of MGH, MIT, and Harvard Liang Cheng, Ph.D. Hao Guo Junichiro Ohori, M.D. University of North Carolina, Chapel Hill University of Pittsburgh School of Hyang-Mi Lee, Ph.D. University of Alabama, Birmingham Medicine University of California, San Diego Talyn Chu SuFey Ong, Ph.D. University of Washington Tingxi Guo Young-Tae Lee, Ph.D. Johns Hopkins University University of Toronto Georgia State University Curtis A. Clark Sterling B. Ortega, Ph.D. University of Texas Health Science Xizhi Guo Yuk Man Lei University of Texas Southwestern Center San Antonio St. Jude Children’s Research Hospital University of Chicago Medical Center Denis Comte, M.D. Corinne Hamblet Robin S. Lindsay Timothy Edward O’Sullivan, Ph.D. Harvard Medical School Johns Hopkins University National Jewish Health/University of Memorial Sloan Kettering Cancer Colorado Center Kevin D. Cook, Ph.D. William Hanes, J.D. University of North Carolina, Chapel Hill Feinstein Institute for Medical Jeremy M. Lott, Ph.D. David L. Owen Research University of Pittsburgh University of Minnesota Leticia Corrales, Ph.D. University of Chicago Geoffrey T. Hart, Ph.D. Julie Marie Lowe, Ph.D. Patrick A. Paez NIAID, NIH NIEHS, NIH Virginia Commonwealth University John S. Davies University of Arizona Yu He, Ph.D. Zhiyuan Lu, Ph.D. Mark J. Palma New York Medical College Georgia State University Rutgers - New Jersey Medical School Diana Diaz-Arevalo, Ph.D. Texas Tech University Health Science Martin P. Hosking, Ph.D. Herbert P. Ludewick, Ph.D. Amy V. Paschall Center Scripps Research Institute Albany Medical College Georgia Regents University Phillip P. Domeier Fokhrul Hossain Chong Luo Simanta Pathak, Ph.D. Pennsylvania State University College of Louisiana State University Health Memorial Sloan Kettering Cancer Center University of Houston Medicine Science Center Cortez C. McBerry, Ph.D. Dongjun Peng, Ph.D. Donye Dominguez Wei-Shan Hung NIAID, NIH University of Michigan Northwestern University Chang-Gung University, Taiwan Arnav Mehta J. David Peske Justin Michael Drerup Tracy In California Institute of Technology University of Virginia University of Texas Health Science Sunnybrook Research Institute Gautam U. Mehta, M.D. Duy Pham Center San Antonio Hyun Yong Jin NINDS, NIH University of Alabama, Birmingham Jeffrey M. Duggan Scripps Research Institute Torsten B. Meissner, Ph.D. Kathryn L. Pothoven University of Washington Dorothy I. Jones, D.V.M. Harvard University Northwestern University Feinberg Alison J. Eastman Duke University David Messenheimer School of Medicine University of Michigan Alice Oliffson Kamphorst, Ph.D. Earle A. Chiles Research Institute/ Catherine Ptaschinski, Ph.D. Ali H. Ellebedy, Ph.D. Emory University Oregon Health & Science University University of Michigan Emory University Gabriel Nathan Kaufman Selene Meza-Perez, Ph.D. Qingsong Qin, Ph.D. C. T. Ellebrecht, M.D. Research Institute - McGill University University of Alabama, Birmingham Pennsylvania State University College of University of Pennsylvania Health Centre Michael T. Moran Medicine Diba Emal Laurie Lea Kenney, Ph.D. University of Cincinnati Itay Raphael Academic Medical Center University of Massachusetts Medical Joshua Michael Moreau University of Texas San Antonio Amsterdam School University of Toronto Ivan Rodriguez Nunez, Ph.D. Wendy Fonseca, Ph.D. Burhan A. Khan Madhur Motwani, M.B.B.S. North Carolina State University University of Michigan NIAID, NIH University College London Rejane Rua, Ph.D. Taylor W. Foreman Shaniya H. Khan Saisha Abhay Nalawade NINDS, NIH Tulane University School of Medicine University of Iowa University of Texas San Antonio Anatoly Rubtsov, Ph.D. Kelley M. Fracchia Ae Kim, Ph.D. Aarti Narang National Jewish Health University of California, Irvine Johns Hopkins University Medical University of South Carolina Hidehito Saito, Ph.D. Anthony M. Franchini, Ph.D. Mi-Jeong Kim, Ph.D. Alina Neunkirchner University of Michigan University of Rochester Joslin Diabetes Center Institute of Immunology, Medical Koustav Sarkar, Ph.D. Meredith Frie Yong Chan Kim, Ph.D. University of Vienna University of Iowa Children’s Hospital Michigan State University Uniformed Services University of the James Stewart New Ismail Sayin Health Sciences Travis J. Friesen University of Alabama, Birmingham Case Western Reserve University University of Washington Thayer King Bin Ni Corey Ray Seehus Emory University Daxing Gao Ohio State University Cedars-Sinai Medical Center University of Texas Southwestern Joanna E. Klementowicz, Ph.D. Randilea Nichols Lillian Seu, Ph.D. Medical Center University of California, San Francisco University of California, Berkeley University of Alabama, Birmingham

www.aai.org AAI Newsletter 67 2015 AAI TRAINEE ABSTRACT AWARDEES

Lei Shi Shivani Srivastava, Ph.D. Julie Tudyk Jonathan M. Williams Georgia State University Fred Hutchinson Cancer Research Center University of Texas San Antonio Vanderbilt University Paurvi R. Shinde Jeffrey Stinson Katia Urso, Ph.D. Cheng-Jang Wu, Ph.D. University of Connecticut Health Center Uniformed Services University of the Brigham and Women’s Hospital University of California, San Diego Health Sciences Stuart Sievers, Ph.D. Natalija Van Braeckel-Budimir, Ph.D. Wei Wu, M.D. California Institute of Technology Ariel D. Stock University of iowa University of Texas Medical Branch Albert Einstein College of Medicine Daniel J. Silburger Rahul Vijay, D.V.M. Jie Yang University of Alabama, Birmingham J. Michael Stolley University of Iowa Pennsylvania State University University of Washington Charles Sinclair, Ph.D. Alicia Michelle Wallis Benjamin C. Yen Emory University Jenna M. Sullivan University of Iowa Icahn School of Medicine at Mount University of Washington Sinai Anju Singh, Ph.D. Bo Wang Trudeau Institute Neil Surana, M.D., Ph.D. Cyrus Tang Hematology Center, James Sundblom Young, Ph.D. Boston Children’s Hospital Soochow University University of Chicago Rani Singh, Ph.D. Forsyth Institute Peter Anthony Szabo Hongxia Wang, Ph.D. Zeb Ralph Zacharias University of Western Ontario Virginia Commonwealth University University of Iowa Varan J. Singh City College of New York Masaki Tajima, Ph.D. Weimin Wang, Ph.D. Roberta Zappasodi, Ph.D. NIAID, NIH University of Michigan Memorial Sloan Kettering Cancer Center Vishal Singh, Ph.D. Pennsylvania State University Carley Tasker Jonathan Weiss, Ph.D. Chao Zhong, Ph.D. Rutgers University Kadmon Pharmaceuticals NIAID, NIH Heather S. Smallwood, Ph.D. St. Jude Children’s Research Hospital Justine Tigno-Aranjuez, Ph.D. Jason White Qifan Zhu Case Western Reserve University University of Colorado St. Jude Children’s Research Hospital Justin Spanier, Ph.D. University of Minnesota Tamara Tilburgs, Ph.D. Ashley J. Wilhelm, Ph.D. Shuting Zuo, Ph.D. Harvard University Vanderbilt University Medical Center University of Pittsburgh Cody M. Spencer, Ph.D. Trudeau Institute

Get a GRIP: An AAI program designed to help new investigators prepare theeir NIH grant proposals The AAI Grant Review for Immuunologists Program (GRIP) offers new principal investigators (PIs) access to established PIs for guidance in preparing graantt proposals as they embark on their independent careers. Early-career PIs (assistant proofessors or equivalents) are invited to submit their grants’ “Specifific Aims” pages to the GRIP cooordinator who, with the assistance ofo a small volunteer subcommittee, will attempt to match each topic of the proposal with the rresearch experience of an estabblished PI. Matches will be made as quickly as possible to allow participants to meet upcooming NIH grant deadlines. Participation is open only to AAI reegular members and is strictly voluntary. The program is not intended to supplant internal mmentoring programs at applicants’ institutions. Too apply, please send your CV and the grant’s “SSpecific Aims” page to [email protected]. (pleease write “GRIP” in the subbject line) To volunteer as a mentor, pleasse send your CV and a brief description of your grant-reviewing experience to [email protected]. (subject line “GRIP”) Program details at aai.org/Education/GRIP

68 AAI Newsletter April 2015 2015 AAI TRAINEE POSTER AWARDEES

Awarded to AAI Trainee Members (students and postdoctoral fellows) whose first-author abstracts are deemed exceptional among abstracts selected exclusively for poster presentation

Nandini Acharya Megan Rose Fisher GilWoo Lee Marina Marlene Scotti University of Connecticut Health University of Pennsylvania Institute of Basic Science, Pohang University of Florida Center University of Science and Technology Osric A. Forrest Padmaja Shastri George W. Agak, Ph.D. Emory University Xiaotian Lin University of Ontario Institute of David Geffen School of Medicine at Scripps Research Institute Technology University of California, Los Angeles Mai Fujiwara University of Connecticut Health Center Yang Liu Thomas R. Shelite, Ph.D. Sreya Bagchi University of Texas Health Science University of Texas Medical Branch Northwestern University K. Alexa Orr Gandy, Ph.D. Center San Antonio University of South Carolina School of Samantha R. Slight-Webb, Ph.D. Rocio Banos-Lara, Ph.D. Medicine Wei Lu, Ph.D. Oklahoma Medical Research Foundation Louisiana State University NIAID, NIH Sheila N. Ganti, Ph.D. InYoung Song Craig M. Brackett, Ph.D. University of Washington Chunchi Lu, M.D. University of Massachusetts Medical Roswell Park Cancer Institute University of Washington School Stephen R. L. Goding, Ph.D. Sadna Budhu, Ph.D. University of Maryland Huanle Luo, Ph.D. Sara Lynn Stone Memorial Sloan Kettering Cancer Center University of Texas Medical Branch University of Alabama, Birmingham Miguel-Angel Gutierrez, Jr. Silvia G. Caballero University of California, Los Angeles Monica Macal, Ph.D. Danfeng Sun, Ph.D. Memorial Sloan Kettering Cancer Center University of California, San Diego University of Michigan Erika Hayes Matthew Calverley, Ph.D. NIAMS, NIH Lauren Aliyah Mack Kruthika Sundaram St. Jude Children's Research Hospital Salk Institute of Biological Studies Ohio State University Timothy M. Hill Christina Chang Vanderbilt University Mati Mann, Ph.D. Paresa L. Taghavie-Moghadam Salk Institute California Institute of Technology Eastern Virginia Medical School Rikke B. Holmgaard, Ph.D. Fei Chen, M.D. Memorial Sloan Kettering Cancer Center Damian Maseda, Ph.D. Paul Todd Thevenot, Ph.D. Rutgers - New Jersey Medical School Vanderbilt University Medical Center Stanley S. Scott Cancer Center, Matthew A. Huggins Louisiana State University Guobing Chen, Ph.D. Mayo Clinic Laura Mathae NIA, NIH University of British Columbia Hung-An Ting Ashvin R. Jaiswal University of Michigan Siqi Chen University of Texas MD Anderson Toshihiro Matsukawa, M.D. Northwestern University Cancer Center Hokkaido University Graduate School Alexander Tsai of Medicine University of Maryland, Baltimore Yu Chen, M.D., Ph.D. Wei Jiang, Ph.D. University of Texas Medical Branch Stanford University Katelynn A. Milora Naomi Tsurutani, Ph.D. Temple University School of Medicine University of Connecticut Health Center Elizabeth E. Cheney Jenny Lynn Johnson University of Colorado Denver Case Western Reserve University Amber M. Paul Miranda Vieson, D.V.M. University of Southern Mississippi VA-MD College of Veterinary Medicine Cansu Cimen Bozkus Laura K. Johnston Purdue University Northwestern University Christopher Charles Paustian, Ph.D. Chun-Shu Wong, Ph.D. Providence Portland Medical Center/ Children's National Medical Center Kimberly Mae Cirelli Yu-Jin Jung Earle A. Chiles Research Institute Massachusetts Institute of Technology Georgia State University Amber N. Woods Liliana Portales-Cervantes, Ph.D. University of Virginia Elisa Cruz Morales, Ph.D. Jenny M. Karo Dalhousie University Massachusetts General Hospital Memorial Sloan Kettering Cancer Center Duojiao Wu Abdulraouf M. Ramadan, Ph.D. Washington University in St.Louis Neha Rajendra Deshpande Jennifer Lee Kielczewski, Ph.D. Indiana University University of Arizona NEI, NIH Autumn Gabrielle York Enyu Rao, Ph.D. University of California, Los Angeles Priyadharshini Devarajan, Ph.D. Kasalina N. Kiwanuka University of Louisville University of Massachusetts Medical Virginia Commonwealth University Hao Yu, Ph.D. School Rachel Samantha Resop University of Alabama, Birmingham Eun-Ju Ko, D.V.M. University of California, Los Angeles Nicola Diny Georgia State University Brian F. Zamarron Johns Hopkins University Eduardo Reyes-Vargas University of Michigan Frederick J. Kohlhapp, Ph.D. University of Utah Jessica L. Doerner Rush University Kathryn Zavala, Ph.D. Albert Einstein College of Medicine Alexander E. Reynolds University of California, Los Angeles Sarah LaMere, D.V.M. Duke University Marc Douaisi, Ph.D. The Scripps Research Institute Franz J. Zemp, Ph.D. Renselaer Polytechnic Institute Jillian P. Rhoads Snyder Institute for Chronic Diseases, Jessica N. Lancaster, Ph.D. Vanderbilt University University of Calgary Kristin Eden, D.V.M. University of Texas, Austin Virginia Polytechnic Institute and Dane W. Samilo State University Tyler Landrith, M.P.H. Memorial Sloan Kettering Cancer Center University of California, Riverside

www.aai.org AAI Newsletter 69 2015 Advanced Course in Immunology August 2–7, 2015 • Seaport World Trade Center, Boston, Massachusetts Director: Leslie J. Berg, Ph.D. University of Massachusetts Medical School

Don’t miss the premier course in immunology for research scientists! This intensive course is directed toward advanced trainees and scientists who wish to expand or update their understanding of the field. Leading experts will present recent advances in the biology of the immune system and address its role in health and disease. This is not an introductory course; attendees will need to have a firm understanding of the principles of immunology. Faculty Marc K. Jenkins, Center for Immunology Kenneth L. Rock, University of Massachusetts University of Minnesota Medical School Medical School Anatomy of the Immune Response MHC-Restricted Antigen Presentation to T Cells Jonathan C. Kagan, Children’s Hospital Boston Leslie J. Berg, University of Massachusetts Harvard Medical School Medical School Innate Immunity: Pattern Recognition and Signaling from Antigen Receptors Anti-microbial Mechanisms Joshy Jacob, Emory University School of Medicine Bruce Horwitz, Brigham & Women’s B Cell Memory Hospital, Harvard Medical School Arup K. Chakraborty, Massachusetts Institute Innate Immunity: Gene Regulation of Technology Albert S. Bendelac, University of Chicago Computational Modeling of Immunological Innate Immunity: Cellular Mechanisms Processes Wayne M. Yokoyama, Washington University Brian A. Cobb, Case Western Reserve University School of Medicine School of Medicine NK Cells —Their Receptors and Function Glycoimmunology in Health and Disease Richard S. Blumberg, Brigham & Women’s Michael C. Carroll, Immune Disease Institute Hospital, Harvard Medical School Harvard Medical School Mucosal Immunity Molecular and Cellular Mediators of Inflammation Joel D. Ernst, New York University School of Medicine Immune Response to Pathogens Brian T. Edelson, Washington University School Jennifer Anolik, University of Rochester Medical Center of Medicine B Cell Tolerance and Autoimmunity Dendritic Cells David Hafler, Yale School of Medicine Eugene M. Oltz, Washington University School T Cell Tolerance and Autoimmunity of Medicine The Generation and Modification of Lymphocyte Lisa H. Butterfield, University of Pittsburgh Antigen Receptor Genes Tumor Immunology Kay L. Medina, Mayo Clinic Joanne L. Viney, Biogen Idec B Cell Development Immunotherapeutics Avinash Bhandoola, NCI, NIH T Cell Development Also included will be lectures on: T Cell Memory and Vaccines

For complete course details and registration, visit: www.aai.org/Education/Courses For assistance, contact (301) 634-7178 or [email protected]. Overseas applicants are advised to apply early for visas; for details, visit www.aai.org/Education/Courses/Visa.html. 70 AAI Newsletter April 2015 Digital Image Dos and Don’ts

Before preparing manuscriptt fi gures, please read the Information forr Authors at http://www.jimmunol.org/site/misc/authorinstructions.xhtml#mspreparation

1.Do nott erase anyy partt off the image, including the background. YES NO

2. Do nott use excessive contrastt thatt removes background. YES NO

3.Make anyy adjustments to brightness orr contrastt equallyy across the entire image. YES NO

Entire image lightened. Contrast changed in three small areas only.

4. Indicate any splicing off data from a single experimentt byy contrasting (blackk orr white) lines; state the manipulation in the legend. Images from differentt experiments should nott be spliced to form a new single image. YES NO

Splicing not marked.

5. Crop gels and blots conservatively, retaining importantt bands. YES NO

• All images submitted to Th e Journal of Immunology must accurately represent the original data. • Original data (digital fi les, autoradiographs, fi lms, etc.) for all experiments should be fully annotated, secured, and retrievable for up to 10 years. • The original image fi le (raw data fi le) should be kept in an unprocessed and non-compressed fi le format. • Figures that are compiled into multi-fi gure panels should be kept individually. www.aai.org AAI Newsletter 71 Chronicling the AAI Legacy 1913–2014

THE SCIENTISTS BEHIND THE SCIENCE

AAI Oral History Project Available Online

o provide contemporary investigators and the public a rare Tvieww into the lives and times off influential immunologists, AAI arranged for the award-winningg Oral Historian Brien Williams, Ph.D., to intervieww past AAI presidents, beginningg in the spring off 2012. Interviewees were asked about their familyy backgrounds, earlyy interest in science, reasons for studyingg immunology, career and research highlights, challenges faced, balancing professional and private life, hobbies outside off the laboratory, major changes in immunologyy over the course off their careers, and the future off immunologyy and science in the United States. The sessions, typicallyy one and one-halff to two hours in length, were professionallyy recorded and edited in high-definition video. “Scientific contributions live on as researchers continue to build upon the workk off the past, yet present-dayy investigators often knoww little about the scientists responsible for them,” said AAI Historian John Emrich, Ph.D., who first conceived off the Oral Historyy Project in 2011. “The ‘Pillars off Immunology’ series in Thee Journall off Immunologyy makes the connections between past and present science more explicit than theyy otherwise would be, but investigators rarelyy have the opportunityy to hear about their predecessors’ motivations, their hardships suffered and overcome, their lives outside off the laboratory, or even their candid thoughts on the state off the field.” To date, 25 past presidents have been interviewed. Their presidential terms span five decades, from that off Herman Eisen (AAI ’51, president 1968–69, noww deceased) to Leslie Berg (AAI ’94, president 2011–12). Included in this group were two past presidents in their 90s, Eisen and David Talmage (AAI ’54, president 1978–79, noww deceased); sixx in their 80s; and four in their 70s. The memories and reflections contained in these interviews constitute an important facet off the historyy of immunologyy that would likelyy be lost to future generations iff not preserved in the AAI Oral Historyy Project. As AAI continues to conduct interviews with additional presidents and other influential immunologists, members and the general public are invited to view the oral histories alreadyy recorded. Video clips and the full-length interviews, which have been optimized for playbackk on TVs, computers, and mobile devices, are available at www.aai.org/ohp.

Oral History Interviews Currently Available: ■ Herman N. Eisen (1968–69) ■ Irvingg L. Weissman (1994–95) ■ Susan L. Swain (2004–05) ■ K. Frankk Austen (1977–78) ■ Richard W. Dutton (1995–96) ■ Paul M. Allen (2005–06) ■ David W. Talmage (1978–79) ■ Katherine L. Knight (1996–97) ■ Lewis L. Lanier (2006–07) ■ Jonathan W. Uhr (1983–84) ■ Roger M. Perlmutter (1999–2000) ■ Oliveraa J. Finn (2007–08) ■ William E. Paul (1986–87) ■ Philippaa Marrackk (2000–01) ■ Arthur Weiss (2008–09) ■ Maxx D. Cooper (1988–89) ■ James P. Allison (2001–02) ■ Bettyy A. Diamond (2009–10) ■ Henryy Metzger (1991–92) ■ Paul W. Kincade (2002–03) ■ Jeffreyy A. Frelinger (2010–11) ■ Frankk W. Fitch (1992–93) ■ Laurie H. Glimcher (2003–04) ■ Leslie J. Bergg (2011–12) ■ Ellen S. Vitettaa (1993–94) 72 AAI Newsletter April 2015 You have the power.

Your membership in the American Association of Immunologists helps advance the field—and your career. Being a part off AAI enables you to take an active role in helping to shape the future off immunology and attain your professional goals. You’ll stand with members representing immunological researchh concerns on Capitol Hill. Plus, you gainn access to: • The bestt and brightestt minds today. • The world’s largestt annual all-immunology meeting. • The Journal off Immunology, the pre-eminent peer-reviewed journal inn the field. • Many occasions and opportunities to presentt your research. • Awards/fellowships/g rants to supportt talented scientists inn every career stage. To learnn more aboutt how your professional life is enriched by membership inn AAI, call 301.634.7195 or visitt www.aai.orgg today. Important Dates for Two AAI Awards Programs AAI Programs to Benefit Your Lab’s Current or Future Research

AAI Careers in AAI Travel for Techniques Immunology Fellowship Award Program

KEY DATES APPLICATIONS OPEN APPLICATIONS CLOSE AWARDS CYCLE APPLICATIONS OPEN APPLICATIONS CLOSE JANUARY 15 MARCH 15 WINTER DECEMBER 15 FEBRUARY 15 SPRING APRIL 15 JUNE 15 These fellowships provide AAI member PIs with one year of FALL AUGUST 15 OCTOBER 15 salary support for a graduate student or postdoctoral fellow in their labs. Member PIs in good standing with less than The Travel for Techniques Award is given to member PIs, $250,000 (excluding PI’s salary) in annual direct costs are reimbursing up to $1,500 in expenses for travel to learn eligible to apply. a new technique. Member PIs in good standing with less Selection is based on the potential of the trainee, merit of the than $250,000 (excluding PI’s salary) in annual direct costs project, quality of the training environment, and fi nancial need. are eligible to apply. Direct inquiries to [email protected]. Direct inquiries to [email protected].

These two exciting awards programs were launched by the American Association of Immunologists in 2014, adding signifi cantly to its already robust support for scientists through fellowships, career awards, and travel grants. For more information, visit www.aai.org/awards. 74 AAI Newsletter April 2015 The latest buzz in innate immunity...

Cyclic Dinucleotide STING Ligands

Cyclic dinucleotides (CDNs) are now among the hottest topics in innate immunity. They bind to and activate STING (stimulator of interferon genes), leading to a potent type I IFN response. CDNs are important second messengers in bacteria as well as in mammalian cells, where they also function as inducers of the innate immune response. They represent a promising new class of vaccine adjuvants. For your research needs, InvivoGen provides CDNs in two grades: Standard Grade and VacciGrade™.

Purity and activity thoroughly validated

Guaranteed endotoxin-free

Available as vaccine adjuvants

MRP

Choose from: c-di-AMP c-di-GMP c-di-IMP c-di-UMP c-GAMP (3’3’, 2’3’ or 2’2’)

www.invivogen.com/cyclic-dinucleotide INNOVATION WITHIN REACH www.aai.org AAI Newsletter 75 BD Multicolor Flow Cytometry A comprehensive approach to advancing your science

Working together to make your science more revealing

Multicolor flow cytometry should help to Our comprehensive catalog of flow cytometry advance your science, not complicate it. That’s systems, antibody specificities, fluorochromes, why we work to deliver innovative solutions tools, and world class support provide flexibility that help make your research efforts more and choice that can meet your unique needs. efficient and more revealing. From brighter Furthermore, BD Biosciences is always working dyes and advanced instrumentation that resolve to move science forward, so your research dim populations of interest to the availability efforts can be faster, easier, and more reliable. of an expert at just the right time, it all works Find out how multicolor flow cytometry from together to help you get quality data out of BD Biosciences can help to advance your science. every study. bdbiosciences.com/go/multicolor

Class 1 Laser Product. BD Biosciences For Research Use Only. Not for use in diagnostic or therapeutic procedures. 2350 Qume Drive BD, BD Logo and all other trademarks are property of Becton, Dickinson and Company. © 2015 BD San Jose, CA 95131 23-17005-00 bdbiosciences.com