DOCSLIB.ORG

Herman N. Eisen: Mentor to Many

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Herman N. Eisen: Mentor to Many RETROSPECTIVE Herman N. Eisen: Mentor to many David M. Kranza,1 and Yuri Sykulevb sitivity to small inorganic molecules was aDepartment of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801; mediated by T cells. The myeloma tumors and bDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas that he had studied in the 1960s also served Jefferson University, Philadelphia, PA 19107 a purpose in his first foray into T cells in the 1970s. In this work, Herman’s laboratory examined the ability of cytotoxic T lympho- Herman Eisen passed away on November 2, Department of Microbiology. In 1973, Herman cytes (CTLs) to recognize and eliminate 2014, at the age of 96. During his long and was recruited to MIT by Salvador Luria, as a myeloma cells (8), for which the myeloma distinguished career, Herman was a mentor founding member of the Center for Cancer protein could serve as an antigen. to those who trained in his laboratory Research. In his autobiography, Luria stated In the early 1980s, Herman decided to (ourselves included), to those who collabo- “Cancer research is incomplete without im- devote more effort toward understanding rated with him over the years, and to many munology....For this job we captured Her- antigen recognition by T cells. His group faculty and colleagues at Massachusetts In- manEisen,aneminentimmunologist” (4). at the time (Fig. 1) was about equally di- stitute of Technology (MIT) and elsewhere. Herman remained active in research at MIT vided between antibody and T-cell proj- He will be missed by all. for the rest of his life. ects. Most individuals who were entering Herman’s long-standing and classic work Herman was a legend in the field of im- the laboratory tried their hand at cloning with antibodies was remarkable, having munology, and his work spanned a wide mouse CTL lines to investigate various yielded many honors, including election to range of topics, all tied together by the theme aspects of the specificity mediated by the the American Academy of Arts and Sci- of antigen recognition and specificity. He then undefined antigen receptor (or recep- ences, the National Academy of Sciences, began a long line of impressive discoveries by tors). One of us (D.M.K.) was charged and the Institute of Medicine, along with the establishing definitively, in a seminal 1949 with trying to identify the T-cell receptor Behring–Heidelberger and Lifetime Achieve- paper with his friend Fred Karush, that an- by producing monoclonal antibodies to ment Awards, both from the American As- tibodies were bivalent (5). Later, Herman was cell surface molecules. Soon this led to a sociation of Immunologists (AAI). He served the first to show that antibodies increase in productive collaborative effort with Susumu as President of the AAI from 1968 to 1969. affinity over time (6) (called affinity matura- Tonegawa, and the genes encoding the In high school, Herman was intrigued by tion), a process that is now used in the de- gamma and alpha chains of T-cell receptors chemistry, but his father persuaded him to velopment of virtually every antibody-based were identified, albeit in a rather circuitous pursue medicine; after clinical training in drug. In a series of studies done before mono- New York in the 1940s, Herman worked at clonal antibodies were available (i.e., from fashion (1). Perhapslessrecognizedisthefactthat,in Columbia University, Sloan Kettering Insti- hybridomas), he showed that myeloma pro- the mid-1980s, Herman’s laboratory was tute, and New York University (1, 2). During teins could be used to understand antigen bind- working on bispecific antibodies (he called this period he was particularly fascinated by ing in a homogeneous, tractable system (7). immune reactions and their specificity, an However, his interest in antibodies was them heteroantibody duplexes) (9), long be- interest that was fueled by Karl Landsteiner’s only the start. After four decades of work in forethemorerecentflurryofactivity.Hewas book, The Specificity of Serological Reactions theantibodyfield,hestartedasecondcareer also among the first to describe some of the (3). To focus more on scientific research, in in the field of T cells. His move into this area components of the CTL killing machinery: 1955, Herman moved from New York Uni- may have been spurred by his earlier experi- theserineesterases.Alookathispapers versity to Washington University in St. Louis, ments, some of which he performed on through those years illustrates how Herman where he ultimately became the Chair of the himself (1, 2), showing that skin hypersen- was involved in many of the early discoveries that have now become textbook material in the recognition and function of T cells. The parallel with his “first career” in the antibody field is striking. In fact, one of us (D.M.K.) once remarked that he seemed like a real-life case of Benjamin Button. After his initial decade of T-cell work, Herman returned to his roots with regard to the understanding of antigen recognition. Coming full circle, in the 1990s, Herman’s laboratory (Fig. 1) identified naturally occur- ring antigens (peptides) recognized by T cells (10, 11), and they measured the affinity and Fig. 1. Herman Eisen’s laboratory at the Center for Cancer Research (MIT) in 1983 (Left) and 1991 (Right). Eisen is on Author contributions: D.M.K. and Y.S. wrote the paper. the far right in both photos. David M. Kranz is to the left of Eisen in the 1983 photo, and Yuri Sykulev is to the left of 1To whom correspondence should be addressed. Email: d-kranz@ Eisen in the 1991 photo. Images courtesy of the authors. illinois.edu. 1650–1651 | PNAS | February 10, 2015 | vol. 112 | no. 6 www.pnas.org/cgi/doi/10.1073/pnas.1500050112 Downloaded by guest on September 29, 2021 kinetics of the T-cell antigen receptor for its ample use of qualifiers to aspects that were A scholar until the end, Herman spent RETROSPECTIVE ligands (12). His deep understanding of the not definitive. He was to our minds the the morning that he passed away working chemical basis of recognition continued to perfect scientist. on a manuscript. Apropos of where it all shape his thinking about the specificity of In the last decade or so, Herman was able to started, the paper considers why antibody these two types of lymphocyte receptors: maintain his science “fix” by working with col- affinities remain quite heterogeneous rather antibodies and T-cell receptors. leagues on their projects. These included a fruit- than evolving toward only high-affinity We, like others in the laboratory, enjoyed ful series of studies with Jianzhu Chen (MIT), species. This is how we will remember immensely the environment that Herman many intellectually satisfying interactions with him, always enjoying the intellectual stim- fostered in his relatively modest-sized labo- Arup Chakraborty (MIT), and the occasional ulation that comes with unanswered ques- ratory. Group meetings were Thursday morn- projects he worked on with both of us. tions in science. ings, and Herman invariably brought coffee cake or cookies from a local bakery. We also had an annual cookout at his place in Woods 1 Eisen HN (2001) Specificity and degeneracy in antigen recognition: populations. Myeloma proteins with antihapten antibody activity. Hole, MA, where Herman loved to spend time Yin and yang in the immune system. Annu Rev Immunol 19:1–21. Fed Proc 29(1):78–84. relaxing with his wife Natalie and tending to 2 Herman N. Eisen, interview by Brien Williams, May 4, 2012, 8 Russell JH, Hale AH, Ginns LC, Eisen HN (1978) Periodic loss of his garden. transcript, The American Association of Immunologists Oral History reactivity of a myeloma tumor with cytotoxic thymus-derived Project, Boston, MA. Available at https://www.aai.org/About/History/ lymphocytes. Proc Natl Acad Sci USA 75(1):441–445. Herman published papers every year since Notable_Members/pdfs/OHP/Transcripts/Trans-Inv_003-Eisen_ 9 Liu MA, et al. (1985) Heteroantibody duplexes target cells for lysis by 1946, spanning eight decades. Writing a paper Herman_N-2012_Final.pdf. Accessed January 8, 2015. cytotoxic T lymphocytes. Proc Natl Acad Sci USA 82(24):8648–8652. with Herman was itself a valuable lesson (if 3 Landsteiner K (1936) The Specificity of Serological Reactions 10 Udaka K, Tsomides TJ, Eisen HN (1992) A naturally occurring (C.C. Thomas, Springfield, IL). peptide recognized by alloreactive CD8+ cytotoxic T not at times frustrating for his postdocs, as 4 Luria SE (1984) A Slot Machine, A Broken Test Tube (Harper and lymphocytes in association with a class I MHC protein. Cell 69(6): a paper could take a year to complete). Early Row, New York). 989–998. 5 Eisen HN, Karush F (1949) The interaction of purified antibody 11 Tsomides TJ, et al. (1994) Naturally processed viral peptides drafts rarely resembled final manuscripts, with homologous hapten; antibody valence and binding constant. recognized by cytotoxic T lymphocytes on cells chronically infected and he carefully studied every word and J Am Chem Soc 71(1):363. by human immunodeficiency virus type 1. JExpMed180(4): phrase. He could frame a problem in terms 6 Eisen HN, Siskind GW (1964) Variations in affinities of antibodies 1283–1293. during the immune response. Biochemistry 3:996–1008. 12 Sykulev Y, et al. (1994) Kinetics and affinity of reactions between that were clear, concise, and important. There 7 Eisen HN, Michaelides MC, Underdown BJ, Schulenburg EP, an antigen-specific T cell receptor and peptide-MHC complexes. was little hype, lots of quantitation, and Simms ES (1970) Experimental approaches to homogenous antibody Immunity 1(1):15–22. Kranz and Sykulev PNAS | February 10, 2015 | vol. 112 | no. 6 | 1651 Downloaded by guest on September 29, 2021.
Load more

Recommended publications
  • Hx of Derm Final
    DERMATOLOGY AT WASHINGTON UNIVERSITY THE TRADITION The tradition of Dermatology at Washington University School of Medicine can be best traced back to the earliest history of the Siteman Cancer Center in the late 1800s. After a tornado destroyed the old City Hospital in 1896, cancer patients were turned away from the emergency quarters that were established in the House of the Good Shephard. In 1905, in an effort to provide free cancer care to the poor, the St. Louis Skin and Cancer Hospital was founded in the old Tuholske Hospital. A few years later, a wealthy St. Louis Barnard Free Skin and Cancer Hospital businessman, George D. Barnard, financed the Barnard Circa ~ 1940. Located on Washington and Free Skin and Cancer Hospital for $130, 000 Theresa St., St, Louis MO. http://www.siteman.wustl.edu/internal.aspx?id=41. In the earliest days of Dermatology in St. Louis, over 50 physicians were trained as dermatologists through the Barnard Free Skin and Cancer Hospital. Early studies conducted at Barnard included work on fungi (Dr. Morris Moore), the epidermis (Dr. E.V. Cowdy) and cancer [1]. This initially free standing 44-bed hospital was later integrated into the Washington University School of Medicine in 1952. The current Barnard Hospital was erected in the Barnes complex in 1954. THE EARLY YEARS In the earliest years of Dermatology associated with Washington University, there were times when there was one “acting head”, and at others, two professors shared the responsibility. The first mention of a practicing dermatologist officially affiliated with Washington University was in the early 1900s.
    [Show full text]
  • Washington University Magazine, Winter 1968
    Washington University School of Medicine Digital Commons@Becker Washington University Magazine Washington University Publications 1968 Washington University Magazine, Winter 1968 Follow this and additional works at: https://digitalcommons.wustl.edu/ad_wumag Recommended Citation "Washington University Magazine, Winter 1968" , . (1968). Bernard Becker Medical Library Archives. Washington University School of Medicine, Saint Louis, Missouri. https://digitalcommons.wustl.edu/ad_wumag/29 This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University Magazine by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. The dance is just one of the lively arts that has become much live/ier at W ashington University Jince the forlllation of a new calll pm-wide, intel'disciplintll} Perforll/illg A rtJ A rea. For more about the recent rellaiJSallce of the performing drtJ on cclmpm, Jee " T he /vlttJes Are H card," beginning on Page 26. WASHINGTON UNIVERSITY uIt~~ u W I NTER 1 968 Vo l. 38, No. 2. Editor Immunology 2 'Vhen 1/ body 'lI eets FRANK O'BRIEl\" an (lnti/JOdu AS.'iis tant Editor JI ~! PATTERSOi'i The Beautiflll Campus 8 A Herb W eitllIall photographic esslIU A ssoc illte Edito r ;\ nd Photop:rnpher H ERB \VEITMAN Technology and th e 20 Dr. Jam es Killian Scienc e Editor Academics adds a postscript ROGER SIGNOR D es igner The Muses Are H eard 26 Renaissance of the PETER GEIST lH'ljormin g arts Visual Pollution 34 An archiiect loo ks of" the urban en1) ironlJl en t Arabi,llls in 'Vy'oming 40 An alumnus Oil .
    [Show full text]
  • Herman N. Eisen: Mentor to Many
    RETROSPECTIVE Herman N. Eisen: Mentor to many David M. Kranza,1 and Yuri Sykulevb sitivity to small inorganic molecules was aDepartment of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801; mediated by T cells. The myeloma tumors and bDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas that he had studied in the 1960s also served Jefferson University, Philadelphia, PA 19107 a purpose in his first foray into T cells in the 1970s. In this work, Herman’s laboratory examined the ability of cytotoxic T lympho- Herman Eisen passed away on November 2, Department of Microbiology. In 1973, Herman cytes (CTLs) to recognize and eliminate 2014, at the age of 96. During his long and was recruited to MIT by Salvador Luria, as a myeloma cells (8), for which the myeloma distinguished career, Herman was a mentor founding member of the Center for Cancer protein could serve as an antigen. to those who trained in his laboratory Research. In his autobiography, Luria stated In the early 1980s, Herman decided to (ourselves included), to those who collabo- “Cancer research is incomplete without im- devote more effort toward understanding rated with him over the years, and to many munology....For this job we captured Her- antigen recognition by T cells. His group faculty and colleagues at Massachusetts In- manEisen,aneminentimmunologist” (4). at the time (Fig. 1) was about equally di- stitute of Technology (MIT) and elsewhere. Herman remained active in research at MIT vided between antibody and T-cell proj- He will be missed by all. for the rest of his life.
    [Show full text]
  • Computational Analyses of Immune Responses at Disparate Temporal and Spatial Scales Mikhail Yanislavovich Wolfson
    Computational Analyses of Immune Responses at Disparate Temporal and Spatial Scales by Mikhail Yanislavovich Wolfson B.S., University of Wisconsin—Madison (2002) Submitted to the Department of Chemistry in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY September 2012 © Massachusetts Institute of Technology 2012. All rights reserved. Author............................................................. Department of Chemistry June 14, 2012 Certified by . Arup K. Chakraborty, Ph.D. Robert T. Haslam Professor of Chemical Engineering Professor of Chemistry and Biological Engineering Thesis Supervisor Accepted by. Robert W. Field, Ph.D. Haslam and Dewey Professor of Chemistry Chairman, Department Committee on Graduate Students 2 This thesis has been examined by a Committee of the Department of Chemistry as follows: Thesis Committee Chair . Troy Van Voorhis, Ph.D. Associate Professor of Chemistry Thesis Supervisor . Arup K. Chakraborty, Ph.D. Robert T. Haslam Professor of Chemical Engineering Professor of Chemistry and Biological Engineering Thesis Committee Member . Mehran Kardar, Ph.D. Francis Friedman Professor of Physics 4 Computational Analyses of Immune Responses at Disparate Temporal and Spatial Scales by Mikhail Yanislavovich Wolfson Submitted to the Department of Chemistry on June 14, 2012, in partial fulfillment of the requirements for the degree of Doctor of Philosophy Abstract In order to perform reliably and protect against unpredictable attackers, immune systems are organized via complex, hierarchical cooperativity. This organization is necessary for their function and a tremendous challenge to their understand- ing that has motivated contributions from many outside fields. Our approach to studying the immune system computationally has been pragmatic: we have ap- plied any analysis method necessary to understand questions motivated by exper- imental biology, rather than use biology specifically to discover new physics or methods.
    [Show full text]
  • Celebrating 40 Years of Rita Allen Foundation Scholars 1 PEOPLE Rita Allen Foundation Scholars: 1976–2016
    TABLE OF CONTENTS ORIGINS From the President . 4 Exploration and Discovery: 40 Years of the Rita Allen Foundation Scholars Program . .5 Unexpected Connections: A Conversation with Arnold Levine . .6 SCIENTIFIC ADVISORY COMMITTEE Pioneering Pain Researcher Invests in Next Generation of Scholars: A Conversation with Kathleen Foley (1978) . .10 Douglas Fearon: Attacking Disease with Insights . .12 Jeffrey Macklis (1991): Making and Mending the Brain’s Machinery . .15 Gregory Hannon (2000): Tools for Tough Questions . .18 Joan Steitz, Carl Nathan (1984) and Charles Gilbert (1986) . 21 KEYNOTE SPEAKERS Robert Weinberg (1976): The Genesis of Cancer Genetics . .26 Thomas Jessell (1984): Linking Molecules to Perception and Motion . 29 Titia de Lange (1995): The Complex Puzzle of Chromosome Ends . .32 Andrew Fire (1989): The Resonance of Gene Silencing . 35 Yigong Shi (1999): Illuminating the Cell’s Critical Systems . .37 SCHOLAR PROFILES Tom Maniatis (1978): Mastering Methods and Exploring Molecular Mechanisms . 40 Bruce Stillman (1983): The Foundations of DNA Replication . .43 Luis Villarreal (1983): A Life in Viruses . .46 Gilbert Chu (1988): DNA Dreamer . .49 Jon Levine (1988): A Passion for Deciphering Pain . 52 Susan Dymecki (1999): Serotonin Circuit Master . 55 Hao Wu (2002): The Cellular Dimensions of Immunity . .58 Ajay Chawla (2003): Beyond Immunity . 61 Christopher Lima (2003): Structure Meets Function . 64 Laura Johnston (2004): How Life Shapes Up . .67 Senthil Muthuswamy (2004): Tackling Cancer in Three Dimensions . .70 David Sabatini (2004): Fueling Cell Growth . .73 David Tuveson (2004): Decoding a Cryptic Cancer . 76 Hilary Coller (2005): When Cells Sleep . .79 Diana Bautista (2010): An Itch for Knowledge . .82 David Prober (2010): Sleeping Like the Fishes .
    [Show full text]
  • Pathbeat1.Pdf
    PathBeat THE DEPARTMENT OF PATHOLOGY ALUMNI NEWSLETTER No. 1/May, 2000 VISION STATEMENT A Department in Transition MISSION STATEMENT I would like to extend my welcome to you on behalf of University of Iowa Health Care's Department of Pathology! As most of you know, I assumed the headship of this department in November 1999 after 19 years of extraordinary leadership by Dick Lynch. This inaugural newsletter is dedicated to the transition in departmental leadership. The Department is proud of its reputation for excellence in patient care, education, and scholarship. We have a long history of accomplishments and I urge you to look at our history. It was researched and written by Fred Stamler, MD, an Emeritus Professor in the Department, who spent his entire career here, primarily as a surgical pathologist. Fred Dee, who currently serves as Vice-Chair for Educational Affairs, kindly wrote additional comments about the Lynch years. We are truly fortunate to have outstanding people within the Department who are dedicated to achieving our goals. I consider myself lucky to help guide this Department into the new millennium. I am fully committed to the professional development of both the faculty and staff in the department. I have been busy since November and with six months under my belt I am still on the steep part of the learning curve. Believing that the transition in leadership has been smooth and effective, I am very optimistic about our future as we strive to reach the goals we have set. I look forward to working with all of you to ensure the continued growth of the Department of Pathology in the future.
    [Show full text]
  • Modest Increase for NIH Offers Small Bright Spot in Just- Passed Funding
    In This Issue… WINTER 2014–2015 3 Focus onon PublicPublic Affairs Affairs: 6 nMembers Government in the News Re-opens n afterFour 16-DayElected Shutdownto IOM: n AAIRafi Recognizes Ahmed 2013 PublicArturo ServiceCasadevall Award HonoreesJames Crowe, Jr. John O’Shea 6 AAI Council Welcomes New Councillorn Jane Salmon JoAnne Flynn 7 JoAnnen Geor geL. Flynn’sTsokos 2013 AAI Candidate’s Statement 13 In Memoriam 8 Members in the News n Herman Eisen n y RandBrutkiewicz n Stephen Kaattari n Ruslan Medzhitov 17 The Journal of Immunology: n Joshua Obar Dos and Don’ts of Image 13 ManipulationIn Memoriam: Yacov Ron, Ph.D. 18 Outreach Program Update 14 AAI Looks Back 20 Grant Review for 22 myIDP Prepares Trainees toImmunologists Transition to Program the “FinalUpdate Frontier” 2522 Re-Cap:High School Summer Teachers 2013 Program AAI IntroductoryParticipants Present Immunology at NABT 24 GrantCourse & Award Deadlines 26 Re-Cap: Summer 2013 AAI 26 AAI Welcomes New Members Advanced Immunology 30 CourseMeetings Calendar 28 AAI Members and Staff Participate in 15th ICI 30 AAI Announces Tiered Awards for the 2014 Modest Increase Trainee Abstract Award Program for NIH Offers Small 32 Grant & Award Deadlines Bright Spot in Just- 34 Meetings & Events Calendar Passed Funding Law See Story on page 4 Important Dates for Two AAI Awards Programs AAI Programs to Benefit Your Lab’s Current or Future Research AAI Careers in AAI Travel for Techniques Immunology Fellowship Award Program KEY DATES APPLICATIONS OPEN APPLICATIONS CLOSE AWARDS CYCLE APPLICATIONS OPEN APPLICATIONS CLOSE JANUARY 15 MARCH 16 WINTER DECEMBER 15 FEBRUARY 15 SPRING APRIL 15 JUNE 15 These fellowships provide AAI member PIs with one year of FALL AUGUST 15 OCTOBER 15 salary support for a graduate student or postdoctoral fellow in their labs.
    [Show full text]
  • Report 1978 Cold Spring Harbor Laboratory
    COLDLABORATORY SPRING HARBOR ANNUAL REPORT 1978 COLD SPRING HARBOR LABORATORY COLD SPRING HARBOR, NEW YORK Cover: Participants at 1978 Symposium (top to bottom) G. Selzer, F. Stahl, and J. Strathern; A. Kornberg, A. Falaschi, and R. Holliday; W. Arber and D. Nathans; W. Udry, A. Bukhari, and D. Baltimore Picture credits: Cover, 82, 90, 140, Ross Meurer; 14, Cindy Carpenter; 19, W. Udry; 11, 12,13, 17, 20, 67, 136, 142, 143, 153, Robert Yaffe COLD SPRING HARBOR LABORATORY COLD SPRING HARBOR, LONG ISLAND, NEW YORK OFFICERS OF THE CORPORATION Dr. Harry Eagle, Chairman Edward Pulling, Vice-Chairman Dr. Bayard Clarkson, Secretary Clarence E. Galston, Treasurer Robert L. Cummings, Assistant Treasurer William R. Udry, Administrative Director BOARD OF TRUSTEES Institutional Trustees Albert Einstein College of Medicine University of Wisconsin Dr. Harry Julian Davies Columbia University Wawepex Society Dr. Charles R. Cantor Bache Bleecker Duke University Dr. Walter Guild Individual Trustees Long Island Biological Association Emilio G. Collado Edward Pulling Robert L. Cummings Massachusetts Institute of Technology Roderick H. Cushman Dr. Herman Eisen Norris Darrell Memorial Sloan-Kettering Cancer Center Walter N. Frank, Jr. Dr. Bayard Clarkson Clarence E. Galston Mary Lindsay New York University Medical Center William S. Robertson Dr. Vittorio Defendi Mrs. Franz Schneider Princeton University Alexander C. Tomlinson Dr. Arnold J. Levine Dr. James D. Watson The Rockefeller University Dr. Rollin Hotchkiss Honorary trustees State University of New York Dr. H. Bentley Glass at Stony Brook Dr. Alexander Hollaender Dr. Joseph R. Kates Officers and trustees listed are as of December 31, 1978 DIRECTOR'S REPORT The collective decisions of knowledgeable men go sourone likes to advertise that we may have no meaningful more often than we want.
    [Show full text]
  • Washington University School of Medicine Bulletin, 1966
    Washington University School of Medicine Digital Commons@Becker Washington University School of Medicine Washington University Publications Bulletins 1966 Washington University School of Medicine bulletin, 1966 Follow this and additional works at: http://digitalcommons.wustl.edu/med_bulletins Recommended Citation Washington University School of Medicine bulletin, 1966. Central Administration, Publications. Bernard Becker Medical Library Archives. Washington University School of Medicine, Saint Louis, Missouri. http://digitalcommons.wustl.edu/med_bulletins/67 This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University School of Medicine Bulletins by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. \**' 7 ■fcjfc vf\ P ■<•. , . 4/^S*^- i**- m -•rp, *." 9 nA »A I !■£«. ilHll I I II! ™ l«WA ON UNIVERSITY IOOI OF MEDICINE 4 J 3 " 2 1 I3a 13b c z> FOREST PARK 16 12 15 17 I—South Building 5—West Building lO—Wohl Hospital 16—Medical Wing Biological Chemistry Microbiology Laboratories of Experimen- Physiology and Biophysics Pathology tal Medicine and Surgery 17—Queeny Tower Pathology Preventive Medicine Pharmacology Student Health Service II—David P. Wohl, Jr. 13—Service Buildinq Memorial—Washington Cafeteria 2—Research Building 6—McMillan Hospital and University Clinics Diagnostic Laboratories Associate Dean's Office Oscar Johnson Institute Registrar's Office Ophthalmology 12—Edward Mallinckrodt Business Offices Otolaryngology Radiological Institute 19—St. Louis Children's Neurology 13—McKinley Avenue Building Hospital, Pediatrics 3—North Building 7—Irene Johnson a. Biomedical Computer 20—Barnard Free Skin and Vice Chancellor's Office Rehabilitation Center Laboratory Cancer Hospital Dean's Office b.
    [Show full text]
  • Herman N. Eisen, MD
    IN MEMORIAM Herman N. Eisen, M.D., AAI ’51 (1918–2014) “I’ve always enjoyed seeing medicine as an outsider and following it, but I enjoy science more... The kind of science I enjoy is dispelling ambiguities. I can’t stand ambiguity. Getting insight to a problem can be pretty rewarding.” Herman Eisen, AAI Oral History Project interview (May 4, 2012) AAI extends condolences to the family, The following tribute was published friends, and colleagues of renowned by MIT and appears with the kind immunologist and past AAI president permission of that institution. Herman N. Eisen, M.D., AAI ’51, who died on November 2 at the age of 96. He was the oldest and second-longest tenured AAI Herman Eisen, Professor member at the time of his death. Emeritus of Biology, Dies at 96 An emeritus professor of biology at Eisen was a pioneering immunologist and Massachusetts Institute of Technology longstanding member of MIT’s cancer (MIT), whose active research career research community. spanned six decades and extended to the Kevin Leonardi, Koch Institute end of his life, Dr. Eisen is perhaps best November 13, 2014 known for groundbreaking research in Herman Eisen, a professor emeritus of which he described affinity maturation, the biology and founding member of the immune system’s ability to adjust antibody MIT Center for Cancer Research, died production to better identify and neutralize Herman Eisen November 2 at age 96. invading pathogens after infection. Over a 70-year career, Eisen forged The recipient of the AAI Lifetime Achievement Award a path as a pioneering immunologist whose research has (1997) and AAI Behring Heidelberger Award (1993), Eisen significantly shaped the field.
    [Show full text]
  • Herman Eisen (1918–2014) Immunologist and Educator Who Discovered Fundamentals of Antibody Binding
    COMMENT OBITUARY Herman Eisen (1918–2014) Immunologist and educator who discovered fundamentals of antibody binding. erman Eisen made fundamental an ultrasensitive method to measure the contributions to our understand- strength of binding — the binding con- ing of how the body’s immune stant, or affinity — of antibodies for Hsystem recognizes foreign structures. chemical entities such as dinitrophenol. In an almost 70-year career, he showed He showed that binding becomes stronger OF MIT COURTESY how antibodies bind to antigens (surface the more time has elapsed since the first molecules on viruses and bacteria) and exposure to an antigen, because cells pro- measured how and why such binding ducing more tightly binding antibodies are strengthens, a concept that now domi- preferentially stimulated as the amount of nates the field of vaccine design. antigen diminishes. After repeated expo- Eisen died in Cambridge, Massa- sure to the same antigen (‘booster’ immu- chusetts, on 2 November. He was born nization) the tightly binding antibodies are in 1918 into the Jewish community of synthesized without delay. Brooklyn, New York, one of four chil- In 1973, he was recruited as a founding dren, to parents who had emigrated from member to the newly established Center Eastern Europe. “I grew up with a sense for Cancer Research (now the Koch Insti- that anti-Semitism in the world around tute for Integrative Cancer Research) at us was pervasive, regarded as a fact of the Massachusetts Institute of Technol- life, like birth and death,” he later wrote. ogy in Cambridge. His research inter- At age 16, he was interested in chemistry ests broadened to include recognition but enrolled as a premedical student at by receptors for antigens on blood cells New York University (NYU), persuaded known as T lymphocytes.
    [Show full text]
  • The Reign of Antibodies: a Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops
    The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops This information is current as Patricia J. Gearhart, Beverly A. Mock, Rafael Casellas and of September 26, 2021. Michael P. Cancro J Immunol 2018; 200:23-26; ; doi: 10.4049/jimmunol.1701516 http://www.jimmunol.org/content/200/1/23 Downloaded from Supplementary http://www.jimmunol.org/content/suppl/2017/12/18/200.1.23.DC1 Material References This article cites 25 articles, 13 of which you can access for free at: http://www.jimmunol.org/ http://www.jimmunol.org/content/200/1/23.full#ref-list-1 Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists by guest on September 26, 2021 • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Th eJournal of Pillars of Immunology Immunology The Reign of Antibodies: A Celebration of and Tribute to Michael Potter and His Homogeneous Immunoglobulin Workshops x Patricia J. Gearhart,* Beverly A. Mock,† Rafael Casellas,‡ and Michael P.
    [Show full text]