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is working for you! Attend the 8th annual Foundation-Thomas K Hunt lecture at the virtual WHS meeting July 25 Margaret A. Liu obtained an M.D. from Harvard Medical School, a B.A. in Chemistry, summa cum laude, from Colorado College, and passed the Epreuve pour le Diplôme d’Enseignement, à l’unanimité (judges’ unanimous decision), in piano from the Ecole Normale de Musique de Paris. She completed Internship and Residency in Internal Medicine and a Fellowship in Endocrinology, all at Massachusetts General Hospital/Harvard Medical School. Previous visiting, faculty, and adjunct faculty appointments were at the Massachusetts Institute of Technology, Harvard Medical School, and The University of Pennsylvania, respectively. Working with Prof. Herman Eisen, known for his seminal work on antibody binding, elucidating the T cell receptor sharpened her immunological skills while a Margaret A. Liu, MD, DSchc, MDhc, FISV Visiting Scientist at MIT. Later while at Merck, she worked closely Karolinska Institutet in Stockholm with Dr. Maurice Hilleman, the legendary vaccinologist who developed more than 40 vaccines. UCSF, San Francisco Use of gene-based vectors for the development of preventions CEO-designate Pax Therapeutics and treatments for infectious diseases and cancer, specifically Saturday July 25, 2020; 10:00AM ET vaccines and immunotherapeutics is Dr. Liu’s expertise. Two of the technologies that she pioneered have now been developed by companies into licensed products: bispecific antibodies for cancer therapy, and DNA vaccines for veterinary applications and which are in numerous human clinical trials for vaccines (for example, one of the first COVID-19 vaccine clinical trials), gene therapy, and immunotherapy for cancer, autoimmune diseases, and allergy. Dr. Liu currently is CEO-designate of PAX Therapeutics, a nascent biotech company using gene delivery of VEGF to optimize healing of ligaments and tendons after surgical repair for rupture. She also consults in the fields of vaccines and immunotherapy for companies, universities, and non-governmental, scientific governmental organizations and international agencies such as WHO, and is a director at Ipsen Pharma. Previous roles included: Senior Director at Merck Research Laboratories, Vice President of Vaccines Research and Gene Therapy at Chiron Corporation, Senior Advisor in Vaccinology at the Bill & Melinda Gates Foundation, Vice-Chairman of Transgene, and Executive Vice-Chair of the International Vaccine Institute (IVI), an independent international organization with signatory countries in Seoul, Korea established by UNDP. Dr. Liu is a Foreign Adjunct Professor at the Karolinska Institutet in Stockholm and an Adjunct Full Professor at the University of California, San Francisco. She is the Chairman of the Board and President Emeritus of the International Society for Vaccines. Dr. Liu has received numerous awards and honors including an NIH Physician Scientist Award. She was invited by the Nobel Committee to lecture in the Karolinska Research Lecture series, was named one of “The 50 Most Important Women in Science” by Discover magazine, has multiple patents, and has been selected for numerous honorary lectureships.She has also had the conferral of two honorary doctorates, the most recent being Medical Doctor honoris causa from the Karolinska Institutet, Stockholm, Sweden. 235 Plain Street, Suite 501 Providence, RI 02905 www.woundhealingfoundation.org WHF is a 501(c)(3) non-profit organization .

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Hx of Derm Final
DERMATOLOGY AT WASHINGTON UNIVERSITY THE TRADITION The tradition of Dermatology at Washington University School of Medicine can be best traced back to the earliest history of the Siteman Cancer Center in the late 1800s. After a tornado destroyed the old City Hospital in 1896, cancer patients were turned away from the emergency quarters that were established in the House of the Good Shephard. In 1905, in an effort to provide free cancer care to the poor, the St. Louis Skin and Cancer Hospital was founded in the old Tuholske Hospital. A few years later, a wealthy St. Louis Barnard Free Skin and Cancer Hospital businessman, George D. Barnard, financed the Barnard Circa ~ 1940. Located on Washington and Free Skin and Cancer Hospital for $130, 000 Theresa St., St, Louis MO. http://www.siteman.wustl.edu/internal.aspx?id=41. In the earliest days of Dermatology in St. Louis, over 50 physicians were trained as dermatologists through the Barnard Free Skin and Cancer Hospital. Early studies conducted at Barnard included work on fungi (Dr. Morris Moore), the epidermis (Dr. E.V. Cowdy) and cancer [1]. This initially free standing 44-bed hospital was later integrated into the Washington University School of Medicine in 1952. The current Barnard Hospital was erected in the Barnes complex in 1954. THE EARLY YEARS In the earliest years of Dermatology associated with Washington University, there were times when there was one “acting head”, and at others, two professors shared the responsibility. The first mention of a practicing dermatologist officially affiliated with Washington University was in the early 1900s.
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Washington University Magazine, Winter 1968
Washington University School of Medicine Digital Commons@Becker Washington University Magazine Washington University Publications 1968 Washington University Magazine, Winter 1968 Follow this and additional works at: https://digitalcommons.wustl.edu/ad_wumag Recommended Citation "Washington University Magazine, Winter 1968" , . (1968). Bernard Becker Medical Library Archives. Washington University School of Medicine, Saint Louis, Missouri. https://digitalcommons.wustl.edu/ad_wumag/29 This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University Magazine by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. The dance is just one of the lively arts that has become much live/ier at W ashington University Jince the forlllation of a new calll pm-wide, intel'disciplintll} Perforll/illg A rtJ A rea. For more about the recent rellaiJSallce of the performing drtJ on cclmpm, Jee " T he /vlttJes Are H card," beginning on Page 26. WASHINGTON UNIVERSITY uIt~~ u W I NTER 1 968 Vo l. 38, No. 2. Editor Immunology 2 'Vhen 1/ body 'lI eets FRANK O'BRIEl\" an (lnti/JOdu AS.'iis tant Editor JI ~! PATTERSOi'i The Beautiflll Campus 8 A Herb W eitllIall photographic esslIU A ssoc illte Edito r ;\ nd Photop:rnpher H ERB \VEITMAN Technology and th e 20 Dr. Jam es Killian Scienc e Editor Academics adds a postscript ROGER SIGNOR D es igner The Muses Are H eard 26 Renaissance of the PETER GEIST lH'ljormin g arts Visual Pollution 34 An archiiect loo ks of" the urban en1) ironlJl en t Arabi,llls in 'Vy'oming 40 An alumnus Oil .
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Herman N. Eisen: Mentor to Many
RETROSPECTIVE Herman N. Eisen: Mentor to many David M. Kranza,1 and Yuri Sykulevb sitivity to small inorganic molecules was aDepartment of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801; mediated by T cells. The myeloma tumors and bDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas that he had studied in the 1960s also served Jefferson University, Philadelphia, PA 19107 a purpose in his first foray into T cells in the 1970s. In this work, Herman’s laboratory examined the ability of cytotoxic T lympho- Herman Eisen passed away on November 2, Department of Microbiology. In 1973, Herman cytes (CTLs) to recognize and eliminate 2014, at the age of 96. During his long and was recruited to MIT by Salvador Luria, as a myeloma cells (8), for which the myeloma distinguished career, Herman was a mentor founding member of the Center for Cancer protein could serve as an antigen. to those who trained in his laboratory Research. In his autobiography, Luria stated In the early 1980s, Herman decided to (ourselves included), to those who collabo- “Cancer research is incomplete without im- devote more effort toward understanding rated with him over the years, and to many munology....For this job we captured Her- antigen recognition by T cells. His group faculty and colleagues at Massachusetts In- manEisen,aneminentimmunologist” (4). at the time (Fig. 1) was about equally di- stitute of Technology (MIT) and elsewhere. Herman remained active in research at MIT vided between antibody and T-cell proj- He will be missed by all. for the rest of his life.
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Computational Analyses of Immune Responses at Disparate Temporal and Spatial Scales by Mikhail Yanislavovich Wolfson B.S., University of Wisconsin—Madison (2002) Submitted to the Department of Chemistry in partial fulfillment of the requirements for the degree of Doctor of Philosophy at the MASSACHUSETTS INSTITUTE OF TECHNOLOGY September 2012 © Massachusetts Institute of Technology 2012. All rights reserved. Author............................................................. Department of Chemistry June 14, 2012 Certified by . Arup K. Chakraborty, Ph.D. Robert T. Haslam Professor of Chemical Engineering Professor of Chemistry and Biological Engineering Thesis Supervisor Accepted by. Robert W. Field, Ph.D. Haslam and Dewey Professor of Chemistry Chairman, Department Committee on Graduate Students 2 This thesis has been examined by a Committee of the Department of Chemistry as follows: Thesis Committee Chair . Troy Van Voorhis, Ph.D. Associate Professor of Chemistry Thesis Supervisor . Arup K. Chakraborty, Ph.D. Robert T. Haslam Professor of Chemical Engineering Professor of Chemistry and Biological Engineering Thesis Committee Member . Mehran Kardar, Ph.D. Francis Friedman Professor of Physics 4 Computational Analyses of Immune Responses at Disparate Temporal and Spatial Scales by Mikhail Yanislavovich Wolfson Submitted to the Department of Chemistry on June 14, 2012, in partial fulfillment of the requirements for the degree of Doctor of Philosophy Abstract In order to perform reliably and protect against unpredictable attackers, immune systems are organized via complex, hierarchical cooperativity. This organization is necessary for their function and a tremendous challenge to their understand- ing that has motivated contributions from many outside fields. Our approach to studying the immune system computationally has been pragmatic: we have ap- plied any analysis method necessary to understand questions motivated by exper- imental biology, rather than use biology specifically to discover new physics or methods.
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Herman N. Eisen: Mentor to Many
RETROSPECTIVE Herman N. Eisen: Mentor to many David M. Kranza,1 and Yuri Sykulevb sitivity to small inorganic molecules was aDepartment of Biochemistry, University of Illinois at Urbana–Champaign, Urbana, IL 61801; mediated by T cells. The myeloma tumors and bDepartment of Microbiology and Immunology, Sidney Kimmel Cancer Center, Thomas that he had studied in the 1960s also served Jefferson University, Philadelphia, PA 19107 a purpose in his first foray into T cells in the 1970s. In this work, Herman’s laboratory examined the ability of cytotoxic T lympho- Herman Eisen passed away on November 2, Department of Microbiology. In 1973, Herman cytes (CTLs) to recognize and eliminate 2014, at the age of 96. During his long and was recruited to MIT by Salvador Luria, as a myeloma cells (8), for which the myeloma distinguished career, Herman was a mentor founding member of the Center for Cancer protein could serve as an antigen. to those who trained in his laboratory Research. In his autobiography, Luria stated In the early 1980s, Herman decided to (ourselves included), to those who collabo- “Cancer research is incomplete without im- devote more effort toward understanding rated with him over the years, and to many munology....For this job we captured Her- antigen recognition by T cells. His group faculty and colleagues at Massachusetts In- manEisen,aneminentimmunologist” (4). at the time (Fig. 1) was about equally di- stitute of Technology (MIT) and elsewhere. Herman remained active in research at MIT vided between antibody and T-cell proj- He will be missed by all. for the rest of his life.
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Report 1978 Cold Spring Harbor Laboratory
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Washington University School of Medicine Bulletin, 1966
Washington University School of Medicine Digital Commons@Becker Washington University School of Medicine Washington University Publications Bulletins 1966 Washington University School of Medicine bulletin, 1966 Follow this and additional works at: http://digitalcommons.wustl.edu/med_bulletins Recommended Citation Washington University School of Medicine bulletin, 1966. Central Administration, Publications. Bernard Becker Medical Library Archives. Washington University School of Medicine, Saint Louis, Missouri. http://digitalcommons.wustl.edu/med_bulletins/67 This Article is brought to you for free and open access by the Washington University Publications at Digital Commons@Becker. It has been accepted for inclusion in Washington University School of Medicine Bulletins by an authorized administrator of Digital Commons@Becker. For more information, please contact [email protected]. \**' 7 ■fcjfc vf\ P ■<•. , . 4/^S*^- i**- m -•rp, *." 9 nA »A I !■£«. ilHll I I II! ™ l«WA ON UNIVERSITY IOOI OF MEDICINE 4 J 3 " 2 1 I3a 13b c z> FOREST PARK 16 12 15 17 I—South Building 5—West Building lO—Wohl Hospital 16—Medical Wing Biological Chemistry Microbiology Laboratories of Experimen- Physiology and Biophysics Pathology tal Medicine and Surgery 17—Queeny Tower Pathology Preventive Medicine Pharmacology Student Health Service II—David P. Wohl, Jr. 13—Service Buildinq Memorial—Washington Cafeteria 2—Research Building 6—McMillan Hospital and University Clinics Diagnostic Laboratories Associate Dean's Office Oscar Johnson Institute Registrar's Office Ophthalmology 12—Edward Mallinckrodt Business Offices Otolaryngology Radiological Institute 19—St. Louis Children's Neurology 13—McKinley Avenue Building Hospital, Pediatrics 3—North Building 7—Irene Johnson a. Biomedical Computer 20—Barnard Free Skin and Vice Chancellor's Office Rehabilitation Center Laboratory Cancer Hospital Dean's Office b.
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Herman N. Eisen, MD
IN MEMORIAM Herman N. Eisen, M.D., AAI ’51 (1918–2014) “I’ve always enjoyed seeing medicine as an outsider and following it, but I enjoy science more... The kind of science I enjoy is dispelling ambiguities. I can’t stand ambiguity. Getting insight to a problem can be pretty rewarding.” Herman Eisen, AAI Oral History Project interview (May 4, 2012) AAI extends condolences to the family, The following tribute was published friends, and colleagues of renowned by MIT and appears with the kind immunologist and past AAI president permission of that institution. Herman N. Eisen, M.D., AAI ’51, who died on November 2 at the age of 96. He was the oldest and second-longest tenured AAI Herman Eisen, Professor member at the time of his death. Emeritus of Biology, Dies at 96 An emeritus professor of biology at Eisen was a pioneering immunologist and Massachusetts Institute of Technology longstanding member of MIT’s cancer (MIT), whose active research career research community. spanned six decades and extended to the Kevin Leonardi, Koch Institute end of his life, Dr. Eisen is perhaps best November 13, 2014 known for groundbreaking research in Herman Eisen, a professor emeritus of which he described affinity maturation, the biology and founding member of the immune system’s ability to adjust antibody MIT Center for Cancer Research, died production to better identify and neutralize Herman Eisen November 2 at age 96. invading pathogens after infection. Over a 70-year career, Eisen forged The recipient of the AAI Lifetime Achievement Award a path as a pioneering immunologist whose research has (1997) and AAI Behring Heidelberger Award (1993), Eisen significantly shaped the field.
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COMMENT OBITUARY Herman Eisen (1918–2014) Immunologist and educator who discovered fundamentals of antibody binding. erman Eisen made fundamental an ultrasensitive method to measure the contributions to our understand- strength of binding — the binding con- ing of how the body’s immune stant, or affinity — of antibodies for Hsystem recognizes foreign structures. chemical entities such as dinitrophenol. In an almost 70-year career, he showed He showed that binding becomes stronger OF MIT COURTESY how antibodies bind to antigens (surface the more time has elapsed since the first molecules on viruses and bacteria) and exposure to an antigen, because cells pro- measured how and why such binding ducing more tightly binding antibodies are strengthens, a concept that now domi- preferentially stimulated as the amount of nates the field of vaccine design. antigen diminishes. After repeated expo- Eisen died in Cambridge, Massa- sure to the same antigen (‘booster’ immu- chusetts, on 2 November. He was born nization) the tightly binding antibodies are in 1918 into the Jewish community of synthesized without delay. Brooklyn, New York, one of four chil- In 1973, he was recruited as a founding dren, to parents who had emigrated from member to the newly established Center Eastern Europe. “I grew up with a sense for Cancer Research (now the Koch Insti- that anti-Semitism in the world around tute for Integrative Cancer Research) at us was pervasive, regarded as a fact of the Massachusetts Institute of Technol- life, like birth and death,” he later wrote. ogy in Cambridge. His research inter- At age 16, he was interested in chemistry ests broadened to include recognition but enrolled as a premedical student at by receptors for antigens on blood cells New York University (NYU), persuaded known as T lymphocytes.
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