Western Michigan University ScholarWorks at WMU Dissertations Graduate College 12-2013 The Partial Characterization of the 142R Protein of Tanapox Virus Krystal N. Seibert Western Michigan University,
[email protected] Follow this and additional works at: https://scholarworks.wmich.edu/dissertations Part of the Virus Diseases Commons Recommended Citation Seibert, Krystal N., "The Partial Characterization of the 142R Protein of Tanapox Virus" (2013). Dissertations. 217. https://scholarworks.wmich.edu/dissertations/217 This Dissertation-Open Access is brought to you for free and open access by the Graduate College at ScholarWorks at WMU. It has been accepted for inclusion in Dissertations by an authorized administrator of ScholarWorks at WMU. For more information, please contact
[email protected]. THE PARTIAL CHARACTERIZATION OF THE 142R PROTEIN OF TANAPOX VIRUS by Krystal N. Seibert A dissertation submitted to the Graduate College in partial fulfillment of the requirements for the degree of Doctor of Philosophy Biological Sciences Western Michigan University December 2013 Doctoral Committee: Bruce Bejcek, Ph.D., Chair John Geiser, Ph.D. Neal Goodwin, Ph.D. THE PARTIAL CHARACTERIZATION OF THE 142R PROTEIN OF TANAPOX VIRUS Krystal N. Seibert, Ph.D. Western Michigan University, 2013 Due to the complex nature of cancer, a variety of strategies are being employed to treat patients. Among these are oncolytic viruses that conditionally replicate in tumor cells with specific cellular landscapes. Several viruses including Herpesviruses, Adenoviruses, and Poxviruses, predominantly vaccinia virus (VV), have been explored for their oncolytic potential. Most of these viruses can productively infect a variety of cell types and it is one goal to create conditionally lethal viruses that can only replicate in tumor cells.