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(12) United States Patent (10) Patent No.: US 8,993,581 B2 Perrine Et Al
US00899.3581B2 (12) United States Patent (10) Patent No.: US 8,993,581 B2 Perrine et al. (45) Date of Patent: Mar. 31, 2015 (54) METHODS FOR TREATINGVIRAL (58) Field of Classification Search DSORDERS CPC ... A61K 31/00; A61K 31/166; A61K 31/185: A61K 31/233; A61K 31/522: A61K 38/12: (71) Applicant: Trustees of Boston University, Boston, A61K 38/15: A61K 45/06 MA (US) USPC ........... 514/263.38, 21.1, 557, 565, 575, 617; 424/2011 (72) Inventors: Susan Perrine, Weston, MA (US); Douglas Faller, Weston, MA (US) See application file for complete search history. (73) Assignee: Trustees of Boston University, Boston, (56) References Cited MA (US) U.S. PATENT DOCUMENTS (*) Notice: Subject to any disclaimer, the term of this 3,471,513 A 10, 1969 Chinn et al. patent is extended or adjusted under 35 3,904,612 A 9/1975 Nagasawa et al. U.S.C. 154(b) by 0 days. (Continued) (21) Appl. No.: 13/915,092 FOREIGN PATENT DOCUMENTS (22) Filed: Jun. 11, 2013 CA 1209037 A 8, 1986 CA 2303268 A1 4f1995 (65) Prior Publication Data (Continued) US 2014/OO45774 A1 Feb. 13, 2014 OTHER PUBLICATIONS Related U.S. Application Data (63) Continuation of application No. 12/890,042, filed on PCT/US 10/59584 Search Report and Written Opinion mailed Feb. Sep. 24, 2010, now abandoned. 11, 2011. (Continued) (60) Provisional application No. 61/245,529, filed on Sep. 24, 2009, provisional application No. 61/295,663, filed on Jan. 15, 2010. Primary Examiner — Savitha Rao (74) Attorney, Agent, or Firm — Nixon Peabody LLP (51) Int. -
(Epstein- Barr Virus) No Líquido Cefalorraquidiano De Crianças Com Suspeita De Meningoencefalite No Estado De Minas
1 Universidade Federal de Minas Gerais Programa de Pós-Graduação em Microbiologia Detecção de human gammaherpesvirus 4 (Epstein- Barr virus) no líquido cefalorraquidiano de crianças com suspeita de meningoencefalite no estado de Minas Gerais Belo Horizonte 2020 2 NATHALIA MARTINS QUINTÃO Detecção de human gammaherpesvirus 4 (Epstein- Barr virus - EBV) no líquido cefalorraquidiano de crianças com suspeita de meningoencefalite no estado de Minas Gerais Dissertação de mestrado apresentada ao Programa de Pós-Graduação em Microbiologia do Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais, como requisito à obtenção do título de Mestre em Microbiologia. Orientadora: Prof.ª. Dr.ª Erna Gessien Kroon Belo Horizonte 2020 3 4 5 RESUMO Epstein-Barr virus pertence à subfamília Gammaherpesvirinae da família Herpesviridae e é o agente etiológico da mononucleose infecciosa. A transmissão de EBV geralmente é pela saliva, sendo o quadro clássico de infecção primária a mononucleose apenas 5% dos casos evoluem para quadros de meningoencefalites. Os grupos de risco são principalmente crianças na primeira infância e pacientes imunocomprometidos. No Brasil, nos últimos 10 anos foram registrados aproximadamente 22 mil casos de meningites e encefalites virais, sendo 52% dos casos em crianças com até 14 anos de idade. O ensaio de PCR em tempo real (qPCR) revoluciona o diagnóstico de neuroinfecções virais. O objetivo deste trabalho foi detectar a presença de DNA genômico e de mRNA de EBV por qPCR para casos de meningoencefalites em pacientes de Minas Gerais e construir, com base na análise de prontuário dos pacientes e dados disponíveis no DATASUS, um breve panorama dos casos de meningoencefalites por EBV. -
2020 Taxonomic Update for Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales
Archives of Virology https://doi.org/10.1007/s00705-020-04731-2 VIROLOGY DIVISION NEWS 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales Jens H. Kuhn1 · Scott Adkins2 · Daniela Alioto3 · Sergey V. Alkhovsky4 · Gaya K. Amarasinghe5 · Simon J. Anthony6,7 · Tatjana Avšič‑Županc8 · María A. Ayllón9,10 · Justin Bahl11 · Anne Balkema‑Buschmann12 · Matthew J. Ballinger13 · Tomáš Bartonička14 · Christopher Basler15 · Sina Bavari16 · Martin Beer17 · Dennis A. Bente18 · Éric Bergeron19 · Brian H. Bird20 · Carol Blair21 · Kim R. Blasdell22 · Steven B. Bradfute23 · Rachel Breyta24 · Thomas Briese25 · Paul A. Brown26 · Ursula J. Buchholz27 · Michael J. Buchmeier28 · Alexander Bukreyev18,29 · Felicity Burt30 · Nihal Buzkan31 · Charles H. Calisher32 · Mengji Cao33,34 · Inmaculada Casas35 · John Chamberlain36 · Kartik Chandran37 · Rémi N. Charrel38 · Biao Chen39 · Michela Chiumenti40 · Il‑Ryong Choi41 · J. Christopher S. Clegg42 · Ian Crozier43 · John V. da Graça44 · Elena Dal Bó45 · Alberto M. R. Dávila46 · Juan Carlos de la Torre47 · Xavier de Lamballerie38 · Rik L. de Swart48 · Patrick L. Di Bello49 · Nicholas Di Paola50 · Francesco Di Serio40 · Ralf G. Dietzgen51 · Michele Digiaro52 · Valerian V. Dolja53 · Olga Dolnik54 · Michael A. Drebot55 · Jan Felix Drexler56 · Ralf Dürrwald57 · Lucie Dufkova58 · William G. Dundon59 · W. Paul Duprex60 · John M. Dye50 · Andrew J. Easton61 · Hideki Ebihara62 · Toufc Elbeaino63 · Koray Ergünay64 · Jorlan Fernandes195 · Anthony R. Fooks65 · Pierre B. H. Formenty66 · Leonie F. Forth17 · Ron A. M. Fouchier48 · Juliana Freitas‑Astúa67 · Selma Gago‑Zachert68,69 · George Fú Gāo70 · María Laura García71 · Adolfo García‑Sastre72 · Aura R. Garrison50 · Aiah Gbakima73 · Tracey Goldstein74 · Jean‑Paul J. Gonzalez75,76 · Anthony Grifths77 · Martin H. Groschup12 · Stephan Günther78 · Alexandro Guterres195 · Roy A. -
Computational Exploration of Virus Diversity on Transcriptomic Datasets
Computational Exploration of Virus Diversity on Transcriptomic Datasets Digitaler Anhang der Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vorgelegt von Simon Käfer aus Andernach Bonn 2019 Table of Contents 1 Table of Contents 1 Preliminary Work - Phylogenetic Tree Reconstruction 3 1.1 Non-segmented RNA Viruses ........................... 3 1.2 Segmented RNA Viruses ............................. 4 1.3 Flavivirus-like Superfamily ............................ 5 1.4 Picornavirus-like Viruses ............................. 6 1.5 Togavirus-like Superfamily ............................ 7 1.6 Nidovirales-like Viruses .............................. 8 2 TRAVIS - True Positive Details 9 2.1 INSnfrTABRAAPEI-14 .............................. 9 2.2 INSnfrTADRAAPEI-16 .............................. 10 2.3 INSnfrTAIRAAPEI-21 ............................... 11 2.4 INSnfrTAORAAPEI-35 .............................. 13 2.5 INSnfrTATRAAPEI-43 .............................. 14 2.6 INSnfrTBERAAPEI-19 .............................. 15 2.7 INSytvTABRAAPEI-11 .............................. 16 2.8 INSytvTALRAAPEI-35 .............................. 17 2.9 INSytvTBORAAPEI-47 .............................. 18 2.10 INSswpTBBRAAPEI-21 .............................. 19 2.11 INSeqtTAHRAAPEI-88 .............................. 20 2.12 INShkeTCLRAAPEI-44 .............................. 22 2.13 INSeqtTBNRAAPEI-11 .............................. 23 2.14 INSeqtTCJRAAPEI-20 -
Enteric and Non-Enteric Adenoviruses Associated with Acute Gastroenteritis in Pediatric Patients in Thailand, 2011 to 2017
RESEARCH ARTICLE Enteric and non-enteric adenoviruses associated with acute gastroenteritis in pediatric patients in Thailand, 2011 to 2017 1,2 1,2 3,4 1,2 Kattareeya Kumthip , Pattara Khamrin , Hiroshi Ushijima , Niwat ManeekarnID * 1 Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 2 Center of Excellence in Emerging and Re-emerging Diarrheal Viruses, Chiang Mai University, Chiang Mai, Thailand, 3 Department of Developmental Medical Sciences, School of International Health, Graduate School of a1111111111 Medicine, The University of Tokyo, Tokyo, Japan, 4 Division of Microbiology, Department of Pathology and a1111111111 Microbiology, Nihon University School of Medicine, Tokyo, Japan a1111111111 * [email protected] a1111111111 a1111111111 Abstract Human adenovirus (HAdV) is known to be a common cause of diarrhea in children world- OPEN ACCESS wide. Infection with adenovirus is responsible for 2±10% of diarrheic cases. To increase a Citation: Kumthip K, Khamrin P, Ushijima H, better understanding of the prevalence and epidemiology of HAdV infection, a large scale Maneekarn N (2019) Enteric and non-enteric and long-term study was needed. We implemented a multi-year molecular detection and adenoviruses associated with acute gastroenteritis characterization study of HAdV in association with acute gastroenteritis in Chiang Mai, Thai- in pediatric patients in Thailand, 2011 to 2017. PLoS ONE 14(8): e0220263. https://doi.org/ land from 2011 to 2017. Out of 2,312 patients, HAdV was detected in 165 cases (7.2%). The 10.1371/journal.pone.0220263 positive rate for HAdV infection was highest in children of 1 and 2 years of age compared to Editor: Wenyu Lin, Harvard Medical School, other age groups. -
Taxonomy of the Order Bunyavirales: Update 2019
Archives of Virology (2019) 164:1949–1965 https://doi.org/10.1007/s00705-019-04253-6 VIROLOGY DIVISION NEWS Taxonomy of the order Bunyavirales: update 2019 Abulikemu Abudurexiti1 · Scott Adkins2 · Daniela Alioto3 · Sergey V. Alkhovsky4 · Tatjana Avšič‑Županc5 · Matthew J. Ballinger6 · Dennis A. Bente7 · Martin Beer8 · Éric Bergeron9 · Carol D. Blair10 · Thomas Briese11 · Michael J. Buchmeier12 · Felicity J. Burt13 · Charles H. Calisher10 · Chénchén Cháng14 · Rémi N. Charrel15 · Il Ryong Choi16 · J. Christopher S. Clegg17 · Juan Carlos de la Torre18 · Xavier de Lamballerie15 · Fēi Dèng19 · Francesco Di Serio20 · Michele Digiaro21 · Michael A. Drebot22 · Xiaˇoméi Duàn14 · Hideki Ebihara23 · Toufc Elbeaino21 · Koray Ergünay24 · Charles F. Fulhorst7 · Aura R. Garrison25 · George Fú Gāo26 · Jean‑Paul J. Gonzalez27 · Martin H. Groschup28 · Stephan Günther29 · Anne‑Lise Haenni30 · Roy A. Hall31 · Jussi Hepojoki32,33 · Roger Hewson34 · Zhìhóng Hú19 · Holly R. Hughes35 · Miranda Gilda Jonson36 · Sandra Junglen37,38 · Boris Klempa39 · Jonas Klingström40 · Chūn Kòu14 · Lies Laenen41,42 · Amy J. Lambert35 · Stanley A. Langevin43 · Dan Liu44 · Igor S. Lukashevich45 · Tāo Luò1 · Chuánwèi Lüˇ 19 · Piet Maes41 · William Marciel de Souza46 · Marco Marklewitz37,38 · Giovanni P. Martelli47 · Keita Matsuno48,49 · Nicole Mielke‑Ehret50 · Maria Minutolo3 · Ali Mirazimi51 · Abulimiti Moming14 · Hans‑Peter Mühlbach50 · Rayapati Naidu52 · Beatriz Navarro20 · Márcio Roberto Teixeira Nunes53 · Gustavo Palacios25 · Anna Papa54 · Alex Pauvolid‑Corrêa55 · Janusz T. Pawęska56,57 · Jié Qiáo19 · Sheli R. Radoshitzky25 · Renato O. Resende58 · Víctor Romanowski59 · Amadou Alpha Sall60 · Maria S. Salvato61 · Takahide Sasaya62 · Shū Shěn19 · Xiǎohóng Shí63 · Yukio Shirako64 · Peter Simmonds65 · Manuela Sironi66 · Jin‑Won Song67 · Jessica R. Spengler9 · Mark D. Stenglein68 · Zhèngyuán Sū19 · Sùróng Sūn14 · Shuāng Táng19 · Massimo Turina69 · Bó Wáng19 · Chéng Wáng1 · Huálín Wáng19 · Jūn Wáng19 · Tàiyún Wèi70 · Anna E. -
Quito's Virome: Metagenomic Analysis of Viral Diversity in Urban Streams of Ecuador's Capital City
Science of the Total Environment 645 (2018) 1334–1343 Contents lists available at ScienceDirect Science of the Total Environment journal homepage: www.elsevier.com/locate/scitotenv Quito's virome: Metagenomic analysis of viral diversity in urban streams of Ecuador's capital city Laura Guerrero-Latorre a,⁎, Brigette Romero a, Edison Bonifaz a, Natalia Timoneda b, Marta Rusiñol b, Rosina Girones b, Blanca Rios-Touma c a Grupo de investigación Biodiversidad, Medio Ambiente y Salud (BIOMAS), Facultad de Ingenierías y Ciencias Aplicadas (FICA), Ingeniería en Biotecnología, Universidad de las Américas, Quito, Ecuador b Laboratory of Virus Contaminants of Water and Food, Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Catalonia, Spain c Grupo de investigación Biodiversidad, Medio Ambiente y Salud (BIOMAS), Facultad de Ingenierías y Ciencias Aplicadas (FICA), Ingeniería Ambiental, Universidad de las Américas, Quito, Ecuador HIGHLIGHTS GRAPHICAL ABSTRACT • First viral metagomic study of highly impacted surface waters in Latin America • The study describes human viral patho- gens present in urban rivers of Quito. • Several viral families detected contain- ing emergent species firstly reported in Ecuador. article info abstract Article history: In Quito, the microbiological contamination of surface water represents a public health problem, mainly due to Received 25 May 2018 the lack of sewage treatment from urban wastewater. Contaminated water contributes to the transmission of Received in revised form 16 July 2018 many enteric pathogens through direct consumption, agricultural and recreational use. Among the different Accepted 16 July 2018 pathogens present in urban discharges, viruses play an important role on disease, being causes of gastroenteritis, Available online 23 July 2018 hepatitis, meningitis, respiratory infections, among others. -
Clinically Important Vector-Borne Diseases of Europe
Natalie Cleton, DVM Erasmus MC, Rotterdam Department of Viroscience [email protected] No potential conflicts of interest to disclose © by author ESCMID Online Lecture Library Erasmus Medical Centre Department of Viroscience Laboratory Diagnosis of Arboviruses © by author Natalie Cleton ESCMID Online LectureMarion Library Koopmans Chantal Reusken [email protected] Distribution Arboviruses with public health impact have a global and ever changing distribution © by author ESCMID Online Lecture Library Notifications of vector-borne diseases in the last 6 months on Healthmap.org Syndromes of arboviral diseases 1) Febrile syndrome: – Fever & Malaise – Headache & retro-orbital pain – Myalgia 2) Neurological syndrome: – Meningitis, encephalitis & myelitis – Convulsions & coma – Paralysis 3) Hemorrhagic syndrome: – Low platelet count, liver enlargement – Petechiae © by author – Spontaneous or persistent bleeding – Shock 4) Arthralgia,ESCMID Arthritis and Online Rash: Lecture Library – Exanthema or maculopapular rash – Polyarthralgia & polyarthritis Human arboviruses: 4 main virus families Family Genus Species examples Flaviviridae flavivirus Dengue 1-5 (DENV) West Nile virus (WNV) Yellow fever virus (YFV) Zika virus (ZIKV) Tick-borne encephalitis virus (TBEV) Togaviridae alphavirus Chikungunya virus (CHIKV) O’Nyong Nyong virus (ONNV) Mayaro virus (MAYV) Sindbis virus (SINV) Ross River virus (RRV) Barmah forest virus (BFV) Bunyaviridae nairo-, phlebo-©, orthobunyavirus by authorCrimean -Congo heamoragic fever (CCHFV) Sandfly fever virus -
Taxonomy of the Order Bunyavirales: Second Update 2018
Archives of Virology (2019) 164:927–941 https://doi.org/10.1007/s00705-018-04127-3 VIROLOGY DIVISION NEWS Taxonomy of the order Bunyavirales: second update 2018 Piet Maes1 · Scott Adkins2 · Sergey V. Alkhovsky3 · Tatjana Avšič‑Županc4 · Matthew J. Ballinger5 · Dennis A. Bente6 · Martin Beer7 · Éric Bergeron8 · Carol D. Blair9 · Thomas Briese10 · Michael J. Buchmeier11 · Felicity J. Burt12,13 · Charles H. Calisher9 · Rémi N. Charrel14 · Il Ryong Choi15 · J. Christopher S. Clegg16 · Juan Carlos de la Torre17 · Xavier de Lamballerie14 · Joseph L. DeRisi18,19,20 · Michele Digiaro21 · Mike Drebot22 · Hideki Ebihara23 · Toufc Elbeaino21 · Koray Ergünay24 · Charles F. Fulhorst6 · Aura R. Garrison25 · George Fú Gāo26 · Jean‑Paul J. Gonzalez27 · Martin H. Groschup28,29 · Stephan Günther30 · Anne‑Lise Haenni31 · Roy A. Hall32 · Roger Hewson33 · Holly R. Hughes34 · Rakesh K. Jain35 · Miranda Gilda Jonson36 · Sandra Junglen37,38 · Boris Klempa37,39 · Jonas Klingström40 · Richard Kormelink41 · Amy J. Lambert34 · Stanley A. Langevin42 · Igor S. Lukashevich43 · Marco Marklewitz37,38 · Giovanni P. Martelli44 · Nicole Mielke‑Ehret45 · Ali Mirazimi46 · Hans‑Peter Mühlbach45 · Rayapati Naidu47 · Márcio Roberto Teixeira Nunes48 · Gustavo Palacios25 · Anna Papa49 · Janusz T. Pawęska50,51 · Clarence J. Peters6 · Alexander Plyusnin52 · Sheli R. Radoshitzky25 · Renato O. Resende53 · Víctor Romanowski54 · Amadou Alpha Sall55 · Maria S. Salvato56 · Takahide Sasaya57 · Connie Schmaljohn25 · Xiǎohóng Shí58 · Yukio Shirako59 · Peter Simmonds60 · Manuela Sironi61 · -
Virosaurus a Reference to Explore and Capture Virus Genetic Diversity
viruses Article Virosaurus A Reference to Explore and Capture Virus Genetic Diversity Anne Gleizes 1, Florian Laubscher 2,3, Nicolas Guex 4, Christian Iseli 4 , Thomas Junier 1,5, Samuel Cordey 2,3 , Jacques Fellay 6,7,8 , Ioannis Xenarios 9 , Laurent Kaiser 2,3,10 and Philippe Le Mercier 11,* 1 Vital-IT Group, SIB Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland; [email protected] (A.G.); thomas.junier@epfl.ch (T.J.) 2 Division of Infectious Diseases, Geneva University Hospitals, 1205 Geneva, Switzerland; [email protected] (F.L.); [email protected] (S.C.); [email protected] (L.K.) 3 Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, 1205 Geneva, Switzerland 4 Bioinformatics Competence Center, University of Lausanne, 1015 Lausanne, Switzerland; [email protected] (N.G.); [email protected] (C.I.) 5 Laboratory of Microbiology, University of Neuchâtel, 2000 Neuchâtel, Switzerland 6 Unité de Médecine de Précision, CHUV, 1015 Lausanne, Switzerland; jacques.fellay@epfl.ch 7 School of Life Sciences, EPFL, 1015 Lausanne, Switzerland 8 Host-Pathogen Genomics Laboratory, Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland 9 Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland; [email protected] 10 Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals, 1205 Geneva, Switzerland 11 Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, 1011 Geneva, Switzerland * Correspondence: [email protected] Received: 16 October 2020; Accepted: 29 October 2020; Published: 1 November 2020 Abstract: The huge genetic diversity of circulating viruses is a challenge for diagnostic assays for emerging or rare viral diseases. -
A Look Into Bunyavirales Genomes: Functions of Non-Structural (NS) Proteins
viruses Review A Look into Bunyavirales Genomes: Functions of Non-Structural (NS) Proteins Shanna S. Leventhal, Drew Wilson, Heinz Feldmann and David W. Hawman * Laboratory of Virology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA; [email protected] (S.S.L.); [email protected] (D.W.); [email protected] (H.F.) * Correspondence: [email protected]; Tel.: +1-406-802-6120 Abstract: In 2016, the Bunyavirales order was established by the International Committee on Taxon- omy of Viruses (ICTV) to incorporate the increasing number of related viruses across 13 viral families. While diverse, four of the families (Peribunyaviridae, Nairoviridae, Hantaviridae, and Phenuiviridae) contain known human pathogens and share a similar tri-segmented, negative-sense RNA genomic organization. In addition to the nucleoprotein and envelope glycoproteins encoded by the small and medium segments, respectively, many of the viruses in these families also encode for non-structural (NS) NSs and NSm proteins. The NSs of Phenuiviridae is the most extensively studied as a host interferon antagonist, functioning through a variety of mechanisms seen throughout the other three families. In addition, functions impacting cellular apoptosis, chromatin organization, and transcrip- tional activities, to name a few, are possessed by NSs across the families. Peribunyaviridae, Nairoviridae, and Phenuiviridae also encode an NSm, although less extensively studied than NSs, that has roles in antagonizing immune responses, promoting viral assembly and infectivity, and even maintenance of infection in host mosquito vectors. Overall, the similar and divergent roles of NS proteins of these Citation: Leventhal, S.S.; Wilson, D.; human pathogenic Bunyavirales are of particular interest in understanding disease progression, viral Feldmann, H.; Hawman, D.W. -
SIVISV.BOOK Layout 1
SEDE Piattaforma FAD Nadirex http://nadirex.dnaconnect.sm ORGANIZING SECRETARIAT AND PROVIDER NR. 265 Nadirex International S.r.l. Via Riviera, 39 - 27100 Pavia Tel. +39.0382.525714 Fax. +39.0382.525736 Contact: Gloria Molla [email protected] mob. +39 347 8589333 Contact: Francesca Granata [email protected] www.nadirex.com www.congressosivsiv.com ORGANIZING COMMITTEE PRESIDENT Arnaldo Caruso (Brescia, Italy) CHAIRS Guido Antonelli (Rome, Italy) Franco Buonaguro (Naples, Italy) Arnaldo Caruso (Brescia, Italy) Massimiliano Galdiero (Naples, Italy) Giuseppe Portella (Naples, Italy) SCIENTIFIC SECRETARIAT Francesca Caccuri (Brescia, Italy) Rossana Cavallo (Turin, Italy) Massimo Clementi (Milan, Italy) Gianluigi Franci (Salerno, Italy) Maria Cristina Parolin (Padua, Italy) Alessandra Pierangeli (Rome, Italy) Luisa Rubino (Bari, Italy) Gabriele Vaccari (Rome, Italy) EXECUTIVE BOARD Guido Antonelli (Rome, Italy) Franco Buonaguro (Naples, Italy) Arnaldo Caruso (Brescia, Italy) Massimiliano Galdiero (Naples, Italy) Giuseppe Portella (Naples, Italy) 3 EXECUTIVE BOARD PRESIDENT Arnaldo Caruso (Brescia, Italy) VICE PRESIDENT Canio Buonavoglia, University of Bari (Bari, Italy) SECRETARY Giorgio Gribaudo, University of Turin (Turin, Italy) TREASURER Luisa Rubino, National Research Council (Bari, Italy) ADVISER Guido Antonelli, University of Rome “La Sapienza” (Rome, Italy) ADVISORY COUNCIL Elisabetta Affabris (Rome, Italy) Fausto Baldanti (Pavia, Italy) Lawrence Banks (Trieste, Italy) Roberto Burioni (Milan, Italy) Arianna Calistri