Taxonomy of the Order Bunyavirales: Update 2019
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Recognition TLR7 Signaling Beyond Endosomal Dendritic Cells
Flavivirus Activation of Plasmacytoid Dendritic Cells Delineates Key Elements of TLR7 Signaling beyond Endosomal Recognition This information is current as of September 29, 2021. Jennifer P. Wang, Ping Liu, Eicke Latz, Douglas T. Golenbock, Robert W. Finberg and Daniel H. Libraty J Immunol 2006; 177:7114-7121; ; doi: 10.4049/jimmunol.177.10.7114 http://www.jimmunol.org/content/177/10/7114 Downloaded from References This article cites 38 articles, 21 of which you can access for free at: http://www.jimmunol.org/content/177/10/7114.full#ref-list-1 http://www.jimmunol.org/ Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication by guest on September 29, 2021 *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2006 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. The Journal of Immunology Flavivirus Activation of Plasmacytoid Dendritic Cells Delineates Key Elements of TLR7 Signaling beyond Endosomal Recognition1 Jennifer P. Wang,2* Ping Liu,† Eicke Latz,* Douglas T. Golenbock,* Robert W. Finberg,* and Daniel H. -
Geographic Distribution of Hantaviruses Associated with Neotomine and Sigmodontine Rodents, Mexico Mary L
Geographic Distribution of Hantaviruses Associated with Neotomine and Sigmodontine Rodents, Mexico Mary L. Milazzo,1 Maria N.B. Cajimat,1 Hannah E. Romo, Jose G. Estrada-Franco, L. Ignacio Iñiguez-Dávalos, Robert D. Bradley, and Charles F. Fulhorst To increase our knowledge of the geographic on the North American continent are Bayou virus, Black distribution of hantaviruses associated with neotomine or Creek Canal virus (BCCV), Choclo virus (CHOV), New sigmodontine rodents in Mexico, we tested 876 cricetid York virus, and Sin Nombre virus (SNV) (3–7). Other rodents captured in 18 Mexican states (representing at hantaviruses that are principally associated with neotomine least 44 species in the subfamily Neotominae and 10 or North American sigmodontine rodents include Carrizal species in the subfamily Sigmodontinae) for anti-hantavirus virus (CARV), Catacamas virus, El Moro Canyon virus IgG. We found antibodies against hantavirus in 35 (4.0%) rodents. Nucleotide sequence data from 5 antibody-positive (ELMCV), Huitzilac virus (HUIV), Limestone Canyon rodents indicated that Sin Nombre virus (the major cause of virus (LSCV), Montano virus (MTNV), Muleshoe virus hantavirus pulmonary syndrome [HPS] in the United States) (MULV), Playa de Oro virus, and Rio Segundo virus is enzootic in the Mexican states of Nuevo León, San Luis (RIOSV) (8–14). Potosí, Tamaulipas, and Veracruz. However, HPS has not Specifi c rodents (usually 1 or 2 closely related been reported from these states, which suggests that in species) are the principal hosts of the hantaviruses, northeastern Mexico, HPS has been confused with other for which natural host relationships have been well rapidly progressive, life-threatening respiratory diseases. -
Phleboviruses and the Type I Interferon Response
viruses Review Phleboviruses and the Type I Interferon Response Jennifer Deborah Wuerth and Friedemann Weber * Institute for Virology, FB10-Veterinary Medicine, Justus-Liebig University, Giessen 35392, Germany; [email protected] * Correspondence: [email protected]; Tel.: +49-641-99-383-50 Academic Editors: Jane Tao and Pierre-Yves Lozach Received: 8 May 2016; Accepted: 20 June 2016; Published: 22 June 2016 Abstract: The genus Phlebovirus of the family Bunyaviridae contains a number of emerging virus species which pose a threat to both human and animal health. Most prominent members include Rift Valley fever virus (RVFV), sandfly fever Naples virus (SFNV), sandfly fever Sicilian virus (SFSV), Toscana virus (TOSV), Punta Toro virus (PTV), and the two new members severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV). The nonstructural protein NSs is well established as the main phleboviral virulence factor in the mammalian host. NSs acts as antagonist of the antiviral type I interferon (IFN) system. Recent progress in the elucidation of the molecular functions of a growing list of NSs proteins highlights the astonishing variety of strategies employed by phleboviruses to evade the IFN system. Keywords: phlebovirus; NSs protein; interferon; RIG-I; PKR 1. Introduction The family Bunyaviridae contains five genera, among which the Orthobunyavirus, Phlebovirus, Nairovirus, and Hantavirus all contain species that are pathogenic to humans and animals, while the genus Tospovirus contains -
ABSTRACT Vector-Borne Viral Infections in South-West
저작자표시-비영리-변경금지 2.0 대한민국 이용자는 아래의 조건을 따르는 경우에 한하여 자유롭게 l 이 저작물을 복제, 배포, 전송, 전시, 공연 및 방송할 수 있습니다. 다음과 같은 조건을 따라야 합니다: 저작자표시. 귀하는 원저작자를 표시하여야 합니다. 비영리. 귀하는 이 저작물을 영리 목적으로 이용할 수 없습니다. 변경금지. 귀하는 이 저작물을 개작, 변형 또는 가공할 수 없습니다. l 귀하는, 이 저작물의 재이용이나 배포의 경우, 이 저작물에 적용된 이용허락조건 을 명확하게 나타내어야 합니다. l 저작권자로부터 별도의 허가를 받으면 이러한 조건들은 적용되지 않습니다. 저작권법에 따른 이용자의 권리는 위의 내용에 의하여 영향을 받지 않습니다. 이것은 이용허락규약(Legal Code)을 이해하기 쉽게 요약한 것입니다. Disclaimer August 2016 Master’s Degree Thesis Vector-Borne Viral Infections in South-West Region of Korea Graduate School of Chosun University Department of Biomedical Sciences Babita Jha August 2016 Master’s Degree Thesis Vector-Borne Viral Infections in South-West Region of Korea Graduate School of Chosun University Department of Biomedical Sciences Babita Jha Vector-Borne Viral Infections in South-West Region of Korea 한국의 남서부 지역에서 매개체 관련 바이러스 질환 August, 2016 Graduate School of Chosun University Department of Biomedical Sciences Babita Jha Vector-Borne Viral Infections in South-West Region of Korea Advisor: Prof. Dong-Min Kim, MD, PhD THESIS SUBMITTED TO THE DEPARTMENT OF BIOMEDICAL SCIENCES, CHOSUN UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF MASTER OF BIOMEDICAL SCIENCES April, 2016 Graduate School of Chosun University Department of Biomedical Sciences Submitted by Babita Jha August Master’s Vector-Borne Viral Infections in Babita Jha Degree 2016 Thesis South-West Region of Korea Table of Contents LIST OF TABLES……………………….................iv LIST OF FIGURES…………………………………v ABBREVIATIONS AND SYMBOLS…………….vi ABSTRACT…………………………………...…….ix 한 글 요 약……………………………………...…..xii I. -
Chapter 11. Phlebotomus Fever—Sandfly Fever
Chapter 11 Phlebotomus Fever—Sandfly Fever Koray Ergunay Hacettepe University Faculty of Medicine, Department of Medical Microbiology, Virology Unit, Ankara, Turkey CASE PRESENTATION During mid-August, a 27-year-old male was admitted to the emergency ward with high fever, chills, severe headache, joint pain, watery diarrhea, nausea and, vomiting, which had started the day before. The initial complete physical examination demonstrated a fever of 38.9C, generalized muscle tenderness, and multiple skin lesions suggesting insect bites on the upper left limb. Neurological examination was normal without meningeal signs. Medical his- tory revealed no previous disease of significance but an exposure to mosqui- toes during his stay at his cousin’s cottage 5 days ago. He had vomited three times during the last 24 hours. No apparent risk for infectious gastroenteritis could be identified. Laboratory evaluation demonstrated decreased leukocyte count (3.8 3 103/μL) with relative lymphocytosis, decreased platelet count (1.32 3 105/μL), elevated alanine aminotransferase (ALT, 101 U/L), aspartate aminotransferase (AST, 128 U/L), gamma glutamyl transpeptidase (GGT, 107 U/L), creatinine phosphokinase (CPK, 428 U/L), and lactate dehydroge- nase (LDH, 354 U/L) levels. Hemoglobulin, C-reactive protein, total protein, blood urea nitrogen (BUN), albumin, creatinine, prothrombin time (PT), acti- vated partial thromboplastin time (aPTT), international normalized ratio (INR), and the chest X-ray were within normal limits. The patient was trans- ferred to the infectious diseases department with the preliminary diagnosis of undifferentiated viral febrile condition, and blood and stool samples were sub- mitted for microbiological analyses. Symptomatic treatment with intravenous rehydration and anti-pyretics was initiated. -
2020 Taxonomic Update for Phylum Negarnaviricota (Riboviria: Orthornavirae), Including the Large Orders Bunyavirales and Mononegavirales
Archives of Virology https://doi.org/10.1007/s00705-020-04731-2 VIROLOGY DIVISION NEWS 2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales Jens H. Kuhn1 · Scott Adkins2 · Daniela Alioto3 · Sergey V. Alkhovsky4 · Gaya K. Amarasinghe5 · Simon J. Anthony6,7 · Tatjana Avšič‑Županc8 · María A. Ayllón9,10 · Justin Bahl11 · Anne Balkema‑Buschmann12 · Matthew J. Ballinger13 · Tomáš Bartonička14 · Christopher Basler15 · Sina Bavari16 · Martin Beer17 · Dennis A. Bente18 · Éric Bergeron19 · Brian H. Bird20 · Carol Blair21 · Kim R. Blasdell22 · Steven B. Bradfute23 · Rachel Breyta24 · Thomas Briese25 · Paul A. Brown26 · Ursula J. Buchholz27 · Michael J. Buchmeier28 · Alexander Bukreyev18,29 · Felicity Burt30 · Nihal Buzkan31 · Charles H. Calisher32 · Mengji Cao33,34 · Inmaculada Casas35 · John Chamberlain36 · Kartik Chandran37 · Rémi N. Charrel38 · Biao Chen39 · Michela Chiumenti40 · Il‑Ryong Choi41 · J. Christopher S. Clegg42 · Ian Crozier43 · John V. da Graça44 · Elena Dal Bó45 · Alberto M. R. Dávila46 · Juan Carlos de la Torre47 · Xavier de Lamballerie38 · Rik L. de Swart48 · Patrick L. Di Bello49 · Nicholas Di Paola50 · Francesco Di Serio40 · Ralf G. Dietzgen51 · Michele Digiaro52 · Valerian V. Dolja53 · Olga Dolnik54 · Michael A. Drebot55 · Jan Felix Drexler56 · Ralf Dürrwald57 · Lucie Dufkova58 · William G. Dundon59 · W. Paul Duprex60 · John M. Dye50 · Andrew J. Easton61 · Hideki Ebihara62 · Toufc Elbeaino63 · Koray Ergünay64 · Jorlan Fernandes195 · Anthony R. Fooks65 · Pierre B. H. Formenty66 · Leonie F. Forth17 · Ron A. M. Fouchier48 · Juliana Freitas‑Astúa67 · Selma Gago‑Zachert68,69 · George Fú Gāo70 · María Laura García71 · Adolfo García‑Sastre72 · Aura R. Garrison50 · Aiah Gbakima73 · Tracey Goldstein74 · Jean‑Paul J. Gonzalez75,76 · Anthony Grifths77 · Martin H. Groschup12 · Stephan Günther78 · Alexandro Guterres195 · Roy A. -
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fmicb-11-621179 December 26, 2020 Time: 15:34 # 1 ORIGINAL RESEARCH published: 08 January 2021 doi: 10.3389/fmicb.2020.621179 Next-Generation Sequencing Reveals a Novel Emaravirus in Diseased Maple Trees From a German Urban Forest Artemis Rumbou1*, Thierry Candresse2, Susanne von Bargen1 and Carmen Büttner1 1 Faculty of Life Sciences, Albrecht Daniel Thaer-Institute of Agricultural and Horticultural Sciences, Humboldt-Universität zu Berlin, Berlin, Germany, 2 UMR 1332 Biologie du Fruit et Pathologie, INRAE, University of Bordeaux, UMR BFP, Villenave-d’Ornon, France While the focus of plant virology has been mainly on horticultural and field crops as well as fruit trees, little information is available on viruses that infect forest trees. Utilization of next-generation sequencing (NGS) methodologies has revealed a significant number of viruses in forest trees and urban parks. In the present study, the full-length genome of a novel Emaravirus has been identified and characterized from sycamore maple Edited by: (Acer pseudoplatanus) – a tree species of significant importance in urban and forest Ahmed Hadidi, areas – showing leaf mottle symptoms. RNA-Seq was performed on the Illumina Agricultural Research Service, HiSeq2500 system using RNA preparations from a symptomatic and a symptomless United States Department of Agriculture, United States maple tree. The sequence assembly and analysis revealed the presence of six genomic Reviewed by: RNA segments in the symptomatic sample (RNA1: 7,074 nt-long encoding the viral Beatriz Navarro, replicase; RNA2: 2,289 nt-long encoding the glycoprotein precursor; RNA3: 1,525 nt- Istituto per la Protezione Sostenibile delle Piante, Italy long encoding the nucleocapsid protein; RNA4: 1,533 nt-long encoding the putative Satyanarayana Tatineni, movement protein; RNA5: 1,825 nt-long encoding a hypothetical protein P5; RNA6: Agricultural Research Service, 1,179 nt-long encoding a hypothetical protein P6). -
Hantavirus Disease Were HPS Is More Common in Late Spring and Early Summer in Seropositive in One Study in the U.K
Hantavirus Importance Hantaviruses are a large group of viruses that circulate asymptomatically in Disease rodents, insectivores and bats, but sometimes cause illnesses in humans. Some of these agents can occur in laboratory rodents or pet rats. Clinical cases in humans vary in Hantavirus Fever, severity: some hantaviruses tend to cause mild disease, typically with complete recovery; others frequently cause serious illnesses with case fatality rates of 30% or Hemorrhagic Fever with Renal higher. Hantavirus infections in people are fairly common in parts of Asia, Europe and Syndrome (HFRS), Nephropathia South America, but they seem to be less frequent in North America. Hantaviruses may Epidemica (NE), Hantavirus occasionally infect animals other than their usual hosts; however, there is currently no Pulmonary Syndrome (HPS), evidence that they cause any illnesses in these animals, with the possible exception of Hantavirus Cardiopulmonary nonhuman primates. Syndrome, Hemorrhagic Nephrosonephritis, Epidemic Etiology Hemorrhagic Fever, Korean Hantaviruses are members of the genus Orthohantavirus in the family Hantaviridae Hemorrhagic Fever and order Bunyavirales. As of 2017, 41 species of hantaviruses had officially accepted names, but there is ongoing debate about which viruses should be considered discrete species, and additional viruses have been discovered but not yet classified. Different Last Updated: September 2018 viruses tend to be associated with the two major clinical syndromes in humans, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary (or cardiopulmonary) syndrome (HPS). However, this distinction is not absolute: viruses that are usually associated with HFRS have been infrequently linked to HPS and vice versa. A mild form of HFRS in Europe is commonly called nephropathia epidemica. -
Emerging Viral Infections Phleboviruses
Emerging viral infections Phleboviruses © by author Anna Papa National ReferenceESCMID Centre Online for Arboviruses Lecture and Hemorrhagic Library Fever viruses Aristotle University of Thessaloniki, Greece Main vectors of phleboviruses: phlebotomine sandflies © by author Etymologia. Phlebotomus: from the Greek words phleboESCMID + tomi=opening Online a vein Lecture Library TAXONOMY Phleboviruses: arthropod-borne RNA viruses Genus Phlebovirus - Family Bunyaviridae Cause to humans symptoms ranging from short self limiting fever to encephalitis and fatal hemorrhagic fever. 70 antigenically distinct serotypes: • Sandfly Fever group – 55 serotypes (most transmitted by sandflies, few by mosquitoes, e.g. Rift Valley fever) •Uukuniemi group – 13 serotypes (transmitted by ticks). • Severe fever and thrombocytopenia syndrome (SFTS) virus (transmitted by ticks). © by author 9 antigenic complexes including 37 classified viruses. Species differentiation based on a 4-fold difference in neutralization tests. High rate of genetic reassortment of the M segment: relying only on neutralizationESCMID or hemagglutination Online Lectureinhibition assays Library is not enough. VIRION Enveloped, spherical. Diameter 80-120 nm. Glycoproteins serve as neutralizing and hemagglutinin-inhibiting antibody targets and are exposed to selective pressure. GENOME Segmented negative- stranded RNA genome. Encodes for © by author 6 proteins. S : N protein and a NSs. Uses an ambisense coding strategy ESCMIDM Online : precursor of Lecturethe viral glycoproteins Library Gn and Gc , and NSm. L : viral RNA polymerase. Phlebotomine sandflies (Psychodidae) • > 500 different species • Widely distributed in Med countries from May to September. The number increases after rainy season. • Abundant in peri-urban and rural environments, close to domestic animals and human populations. • A cool, shaded, slightly damp The sandfly becomes infected environment is ideal for the sandfly life. -
Variability of Emaravirus Species Associated with Sterility Mosaic Disease of Pigeonpea in India Provides Evidence of Segment Reassortment
Article Variability of Emaravirus Species Associated with Sterility Mosaic Disease of Pigeonpea in India Provides Evidence of Segment Reassortment Basavaprabhu L. Patil*, Meenakshi Dangwal and Ritesh Mishra ICAR‐National Research Centre on Plant Biotechnology, IARI, Pusa Campus, New Delhi 110012, India; [email protected] (M.D.); [email protected] (R.M.) * Correspondence: [email protected]; [email protected] Academic Editor: K. Andrew White Received: 16 May 2017; Accepted: 6 July 2017; Published: 11 July 2017 Abstract: Sterility mosaic disease (SMD) of pigeonpea is a serious constraint for cultivation of pigeonpea in India and other South Asian countries. SMD of pigeonpea is associated with two distinct emaraviruses, Pigeonpea sterility mosaic virus 1 (PPSMV‐1) and Pigeonpea sterility mosaic virus 2 (PPSMV‐2), with genomes consisting of five and six negative‐sense RNA segments, respectively. The recently published genome sequences of both PPSMV‐1 and PPSMV‐2 are from a single location, Patancheru from the state of Telangana in India. However, here we present the first report of sequence variability among 23 isolates of PPSMV‐1 and PPSMV‐2, collected from ten locations representing six states of India. Both PPSMV‐1 and PPSMV‐2 are shown to be present across India and to exhibit considerable sequence variability. Variability of RNA3 sequences was higher than the RNA4 sequences for both PPSMV‐1 and PPSMV‐2. Additionally, the sixth RNA segment (RNA6), previously reported to be associated with only PPSMV‐2, is also associated with isolates of PPSMV‐1. Multiplex reverse transcription PCR (RT‐PCR) analyses show that PPSMV‐1 and PPSMV‐2 frequently occur as mixed infections. -
A New Emaravirus Discovered in Pistacia from Turkey
Virus Research 263 (2019) 159–163 Contents lists available at ScienceDirect Virus Research journal homepage: www.elsevier.com/locate/virusres Short communication A new emaravirus discovered in Pistacia from Turkey T ⁎ Nihal Buzkana, , Michela Chiumentib, Sébastien Massartc, Kamil Sarpkayad, Serpil Karadağd, Angelantonio Minafrab a Dep. of Plant Protection, Faculty of Agriculture, University of Sütçü Imam, Kahramanmaras 46060, Turkey b Institute for Sustainable Plant Protection, CNR, Via Amendola 122/D, Bari 70126, Italy c Plant Pathology Laboratory, TERRA-Gembloux Agro-Bio Tech, University of Liège, Passage des Déportés, 2, 5030 Gembloux, Belgium d Pistachio Research Institute, University Blvd., 136/C 27060 Sahinbey, Gaziantep, Turkey ARTICLE INFO ABSTRACT Keywords: High throughput sequencing was performed on total pooled RNA from six Turkish trees of Pistacia showing Emaravirus different viral symptoms. The analysis produced some contigs showing similarity with RNAs of emaraviruses. High throughput sequencing Seven distinct negative–sense, single-stranded RNAs were identified as belonging to a new putative virus in- Pistachio fecting pistachio. The amino acid sequence identity compared to homologs in the genus Emaravirus ranged from 71% for the replicase gene on RNA1, to 36% for the putative RNA7 gene product. All the RNA molecules were verified in a pistachio plant by RT-PCR and conventional sequencing. Although the analysed plants showeda range of symptoms, it was not possible to univocally associate the virus with a peculiar one. The possible virus transmission by mite vector needs to be demonstrated by a survey, to observe spread and potential effect on yield in the growing areas of the crop. Pistachio (Pistacia spp.) is an important crop worldwide, with a ampelovirus A) and a pistachio variant of a viroid (Citrus bark cracking global production of more than 1 million tons (FAOstat, 2016). -
Interaction with Other Flaviviruses (Pre-Existing Immunity, Co-Infection, Cross- Reactivity)
Interaction with other flaviviruses (pre-existing immunity, co-infection, cross- reactivity) Alan D.T. Barrett Department of Pathology Sealy Center for Vaccine Development University of Texas Medical Branch Galveston TX Flavivirus genome 50nm particle. SS, +RNA genome. 10 genes, 3 structural. Beck, A. Barrett, ADT. (2015) Exp Rev Vaccines. 1-14. 2 Flavivirus E protein epitopes • Studies with human and mouse polyclonal sera show extensive serologic cross-reactivities between flaviviruses in terms of physical (ELISA) and biological (HAI and neutralization) assays • Studies with mouse, non-human primate, and human monoclonal antibodies show essentially the same result that all flaviviruses studied to date have a range of E protein epitopes ranging in flavivirus cross-reactive (e.g., mab 4G2 or 6B6C-1), to flavivirus intermediate (e.g., mab 1B7), to serocomplex specific (e.g., DENV-1 to DENV-4; mab MDVP-55A), to flavivirus species specific (e.g., mab 3H5 that is DENV-2 specific). Strain specific epitopes are rare. • Flavivirus infection induces a range of antibodies, including those that recognize multiple flaviviruses. A second, but different, flavivirus infection potentiates induction of flavivirus cross-reactive antibodies. • Most epitopes are “conformational” or “quaternary”. Very few epitopes are linear. Very few epitopes appear to elicit high titer neutralizing antibodies. Reactivity of anti-E protein mouse monoclonal antibodies raised against YF 17D vaccine with YF and 37 other flaviviruses RH: Rabbit hyperimune sera Gould et al., 1985 Reactivity of anti-E protein mouse monoclonal antibodies raised against YF 17D vaccine with YF and 37 other flaviviruses RH: Rabbit hyperimune sera Gould et al., 1985 Reactivity of anti-E and anti-NS1 protein mouse monoclonal antibodies raised against YF 17D vaccine with different YF strains Flavivirus NS1 protein Less flavivirus cross-reactive epitopes than E protein, but some still identified.