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Experimental Infection of Dogs with Toscana Virus and Sandfly
microorganisms Article Experimental Infection of Dogs with Toscana Virus and Sandfly Fever Sicilian Virus to Determine Their Potential as Possible Vertebrate Hosts Clara Muñoz 1, Nazli Ayhan 2,3 , Maria Ortuño 1, Juana Ortiz 1, Ernest A. Gould 2, Carla Maia 4, Eduardo Berriatua 1 and Remi N. Charrel 2,* 1 Departamento de Sanidad Animal, Facultad de Veterinaria, Campus de Excelencia Internacional Regional “Campus Mare Nostrum”, Universidad de Murcia, 30100 Murcia, Spain; [email protected] (C.M.); [email protected] (M.O.); [email protected] (J.O.); [email protected] (E.B.) 2 Unite des Virus Emergents (UVE: Aix Marseille Univ, IRD 190, INSERM U1207, IHU Mediterranee Infection), 13005 Marseille, France; [email protected] (N.A.); [email protected] (E.A.G.) 3 EA7310, Laboratoire de Virologie, Université de Corse-Inserm, 20250 Corte, France 4 Global Health and Tropical Medicine, GHMT, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira, 100, 1349-008 Lisboa, Portugal; [email protected] * Correspondence: [email protected] Received: 2 April 2020; Accepted: 19 April 2020; Published: 20 April 2020 Abstract: The sandfly-borne Toscana phlebovirus (TOSV), a close relative of the sandfly fever Sicilian phlebovirus (SFSV), is one of the most common causes of acute meningitis or meningoencephalitis in humans in the Mediterranean Basin. However, most of human phlebovirus infections in endemic areas either are asymptomatic or cause mild influenza-like illness. To date, a vertebrate reservoir for sandfly-borne phleboviruses has not been identified. Dogs are a prime target for blood-feeding phlebotomines and are the primary reservoir of human sandfly-borne Leishmania infantum. -
Complete Sections As Applicable
This form should be used for all taxonomic proposals. Please complete all those modules that are applicable (and then delete the unwanted sections). For guidance, see the notes written in blue and the separate document “Help with completing a taxonomic proposal” Please try to keep related proposals within a single document; you can copy the modules to create more than one genus within a new family, for example. MODULE 1: TITLE, AUTHORS, etc (to be completed by ICTV Code assigned: 2015.006aM officers) Short title: Implementation of taxon-wide non-Latinized binomial species names in the family Rhabdoviridae (e.g. 6 new species in the genus Zetavirus) Modules attached 1 2 3 4 5 (modules 1 and 10 are required) 6 7 8 9 10 Author(s): ICTV Rhabdoviridae Study Group: Walker, Peter Chair Australia [email protected] Blasdell, Kim Member Australia [email protected] Calisher, Charlie H. Member USA [email protected] Dietzgen, Ralf G. Member Australia [email protected] Kondo, Hideki Member Japan [email protected] Kurath, Gael Member USA [email protected] Longdon, Ben Member UK [email protected] Stone, David Member UK [email protected] Tesh, Robert B. Member USA [email protected] Tordo, Noël Member France [email protected] Vasilakis, Nikos Member USA [email protected] Whitfield, Anna Member USA [email protected] and Kuhn, Jens H., [email protected] Corresponding author with e-mail address: Walker, Peter (ICTV Rhabdoviridae Study Group Chair), [email protected] List the ICTV study group(s) that have seen this proposal: A list of study groups and contacts is provided at http://www.ictvonline.org/subcommittees.asp . -
Sandfly Fever
& My gy co lo lo ro g i y V Tufan and Tasyaran, Virol Mycol 2013, 2:1 Virology & Mycology DOI: 10.4172/2161-0517.1000109 ISSN: 2161-0517 Short Communication Open Access Sandfly Fever: A Mini Review Zeliha Kocak Tufan*, Mehmet A Tasyaran and Tumer Guven Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ataturk Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey Introduction TOSV differs from others with its neurotropism and being an etiologic agent of central nervous system infection [24]. Although Sandfly fever, also known as Pappataci fever or phlebotomus fever the SFSV usually causes a self limited benign disease, there are some is an interesting disease mimicking other conditions which causes evidences that SFTV may lead to more severe disease, prolonged fever fever, myalgia and malaise along with abnormalities in liver enzymes and laboratory abnormalities even with neurological involvement and hematological test results [1]. Without suspicion of the disease [1,25]. itself or a presence of an epidemic, it is very hard to diagnose this disease in a non-endemic area, particularly if it is travel associated and The Mediterranean basin is the main area for sandfly fever. Reports if the anamnesis is not clear [1-5]. The differential diagnosis consists are increasingly published every day related with the presence of the of a very board spectrum list of diseases such as viral, parasitic and vector, the virus or the infection itself, from Spain to Croatia, from bacterial infections. Even hematologic malignancies and bone marrow Morocco to Iran, Italy, Portugal and Turkey [7-13,26,27]. -
(Sandfly Fever Naples Virus Species) In
Ayhan et al. Parasites & Vectors (2017) 10:402 DOI 10.1186/s13071-017-2334-y SHORT REPORT Open Access Direct evidence for an expanded circulation area of the recently identified Balkan virus (Sandfly fever Naples virus species) in several countries of the Balkan archipelago Nazli Ayhan1, Bulent Alten2, Vladimir Ivovic3, Vit Dvořák4, Franjo Martinkovic5, Jasmin Omeragic6, Jovana Stefanovska7, Dusan Petric8, Slavica Vaselek8, Devrim Baymak9, Ozge E. Kasap2, Petr Volf4 and Remi N. Charrel1* Abstract Background: Recently, Balkan virus (BALKV, family Phenuiviridae, genus Phlebovirus) was discovered in sand flies collected in Albania and genetically characterised as a member of the Sandfly fever Naples species complex. To gain knowledge concerning the geographical area where exposure to BALKV exists, entomological surveys were conducted in 2014 and 2015, in Croatia, Bosnia and Herzegovina (BH), Kosovo, Republic of Macedonia and Serbia. Results: A total of 2830 sand flies were trapped during 2014 and 2015 campaigns, and organised as 263 pools. BALKV RNA was detected in four pools from Croatia and in one pool from BH. Phylogenetic relationships were examined using sequences in the S and L RNA segments. Study of the diversity between BALKV sequences from Albania, Croatia and BH showed that Albanian sequences were the most divergent (9–11% [NP]) from the others and that Croatian and BH sequences were grouped (0.9–5.4% [NP]; 0.7–5% [L]). The sand fly infection rate of BALKV was 0.26% in BH and 0.27% in Croatia. Identification of the species content of pools using cox1 and cytb partial regions showed that the five BALKV positive pools contained Phlebotomus neglectus DNA; in four pools, P neglectus was the unique species, whereas P. -
Original Article Applied Research Progress of the Ecological Niche in Vector-Borne Disease
Int J Clin Exp Med 2016;9(3):6642-6648 www.ijcem.com /ISSN:1940-5901/IJCEM0019109 Original Article Applied research progress of the ecological niche in vector-borne disease Xiangjuan Li, Wenwang Wu, Jin Fang, Fengfen Zhang, Yangguang Qin Guangxi International Travel Health Care Center, Nanning 530021, Guangxi, China Received November 3, 2015; Accepted February 10, 2016; Epub March 15, 2016; Published March 30, 2016 Abstract: In recent years, zoonotic infectious diseases, such as Middle East Respiratory Syndrome (MERS), Ebola, highly pathogenic avian influenza, bovine spongiform encephalopathy (BSE), Severe Acute Respiratory Syndromes (SARS), West Nile fever et al. become an increasing threat to human beings through a variety of transmission routes. It has been currently reported that at least more than 200 kinds of animal infectious diseases and parasitic diseases can be transmitted to humans, which are known as zoonotic infectious diseases. Ecological niche study was conducted to determine the effect of different environmental risk factors on the transmission of vector borne infectious diseases.The literature search was made of articles published up until July 2015 in PubMed. Inclusion criteria contained ecological studies for vector-borne and zoonotic diseases that used ecological niche models. Abstracts and full texts were read and evaluated by two independent readers.We investigate the evidence of 37 studies from a total of 187 selected in PubMed. Initially, 187 abstracts were found in the PubMed, among which 154 full-text articles were retrieved. After screening abstracts and titles, 83 citations were rejected because they were not for vector-borne and zoonotic diseases. 71 abstracts fulfilled the predefined criteria and were included as full texts. -
Overview of West Nile Virus and Sandfly-Borne Phlebovirus Infections in Anatolia
Journal of Microbiology and Infectious Diseases / 2014; Special Issue 1: S22-S31 JMID doi: 10.5799/ahinjs.02.2014.S1.0138 REVIEW ARTICLE Overview of West Nile Virus and Sandfly-borne Phlebovirus Infections in Anatolia Koray Ergünay1, Zeliha Koçak Tufan2 1 Hacettepe University Faculty of Medicine, Department of Medical Microbiology, Virology Unit, Ankara, Turkey 2 Yildirim Beyazit University, Ankara Ataturk Training & Research Hospital, Infectious Diseases & Clinical Microbiology Department, Ankara, Turkey ABSTRACT Arthropod-borne (arbo) viruses are trafinsmitted to the susceptible hosts by blood-feeding arthropods such as mosqui- toes, sandflies and ticks. Arboviral infections have had a significant global public health impact during the last decades due to their resurgence and dynamic epidemiologic features. In Turkey, cases and outbreaks due to previously underes- timated arboviral infections have emerged since 2009. In this manuscript, previous and current data on two of the major arboviral infections, West Nile virus and Sandfly-borne Phleboviruses have been overviewed with a special emphasis on clinical presentation and laboratory evaluation. J Microbiol Infect Dis 2014; Special Issue 1: S22-S31 Key words: Arboviruses, West Nile Virus, WNV, Phlebotomus fever, Phlebovirus, Turkey Türkiye’de Batı Nil Virusu ve Flebovirus Enfeksiyonlarına Genel Bakış ÖZET Artropod kaynaklı (arbo) viruslar, duyarlı konaklara sivrisinek, kum sineği ve kene gibi artropodların kan emmesi yoluyla bulaşır. Son yıllarda yeniden ortaya çıkan ve epidemiyolojik özelliklerinde değişiklikler izlenen çeşitli arboviral enfeksi- yonlar, tüm dünyada önemli halk sağlığı sorunları oluşturmaktadır. Türkiye’de 2009 yılından günümüze, daha önce dikkat çekmemiş bazı arboviruslara bağlı olgular ve salgınlar ortaya çıkmıştır. Bu derlemede, iki önemli arbovirus olan Batı Nil virusu ve kum sineği (tatarcık) kaynaklı fleboviruslarla ilgili ülkemize ait veriler, klinik ve laboratuvar bulguları özellikle vurgulanarak ele alınmaktadır. -
Sciencedirect.Com Sciencedirect
AIX-MARSEILLE UNIVERSITE FACULTE DE MEDECINE DE MARSEILLE ECOLE DOCTORALE DES SCIENCES DE LA VIE ET DE LA SANTE THESE DE DOCTORAT Présentée par NAZLI AYHAN Née le 1er Juillet 1988 née en Turquie En vue de l’obtention du grade de DOCTEUR d’AIX-MARSEILLE UNIVERSITE Mention : Pathologie Humaine Spécialité : Maladies Infectieuses Emerging Sandfly-borne Phleboviruses in Balkan Countries: Virus isolation, Characterization, Evolution and Seroepidemiology Soutenue publiquement le 26 Septembre 2017 Composition du Jury : Monsieur le Docteur Christophe PAUPY Rapporteur Monsieur le Professeur Christophe PEYREFITTE Rapporteur Madame le Docteur Dorothée MISSE Examinateur Monsieur le Professeur Remi N CHARREL Directeur de Thése UMR "Emergence des Pathologies Virales" (EPV : Aix-Marseille Univ – IRD 190 – Inserm 1207 – EHESP – IHU Méditerranée Infection), Marseille, France ACKNOWLEDGEMENTS I would like to express my very great appreciation to Dr. Xavier de Lamballerie for giving me the opportunity to do my Ph.D. in his laboratory. His knowledge and enthusiasm on virology always encourage me to be a good scientist. I would like to express my deep gratitude to Dr. Remi N. Charrel, my research supervisor, for accepting me as a Ph.D. student, his guidance, enthusiastic encouragement and useful critiques of this research. He is the best supervisor ever. Big thanks to Dr. Christophe Paupy, Dr. Christophe Peyrefitte and Dr. Dorothée Misse for accepting to be in the thesis committee and their valuable comments. I would like to offer my special thanks to Dr. Bulent Alten for his precious support and contributions to this thesis. I thank Dr. Bulent Alten, Dr. Vladimir Ivovic and Dr. Petr Volf for organizing the sand fly field collection campaign in Balkan countries, it was an incredible experience for me. -
Seroprevalence of Sandfly Fever Virus Infection in Military Personnel On
Journal of Infection and Public Health (2017) 10, 59—63 View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Seroprevalence of sandfly fever virus infection in military personnel on the western border of Iran a,c,∗ b a Ramin Shiraly , Afra Khosravi , Saman Farahangiz a Department of Community Medicine, Shiraz University of Medical Sciences, Shiraz, Iran b Department of Immunology, Ilam University of Medical Sciences, Ilam, Iran c Psychosocial Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran Received 17 November 2015; received in revised form 22 January 2016; accepted 20 February 2016 KEYWORDS Summary Military troops deployed to endemic areas are at risk of contracting Sandfly fever; sandfly fever, an arthropod-borne viral infection. Although typically a self-limited Virus; disease, sandfly fever can cause significant morbidity and loss of function among Past infection; soldiers. We conducted this study to determine the extent of past SFV infection in a group of healthy Iranian military personnel in Ilam province on the western border of Military personnel Iran. A total of 201 serum samples were tested by indirect immunofluorescence assay (IFA) to detect four common sandfly fever virus serotypes. Demographic data were also collected. Overall, 37 samples (18.4%) were positive for specific IgG antibodies to sandfly viruses. Sandfly fever Sicilian virus (SFSV) and sandfly fever Naples virus (SFNV) were the most common serotypes. A positive test was inversely related to nativity (P < 0.01) but was not associated with age (P = 0.163), duration of presence in the border region (P = 0.08) or employment status (P = 0.179). -
Commission Directive (Eu)
L 279/54 EN Offi cial Jour nal of the European Union 31.10.2019 COMMISSION DIRECTIVE (EU) 2019/1833 of 24 October 2019 amending Annexes I, III, V and VI to Directive 2000/54/EC of the European Parliament and of the Council as regards purely technical adjustments THE EUROPEAN COMMISSION, Having regard to the Treaty on the Functioning of the European Union, Having regard to Directive 2000/54/EC of the European Parliament and of the Council of 18 September 2000 on the protection of workers from risks related to exposure to biological agents at work (1), and in particular Article 19 thereof, Whereas: (1) Principle 10 of the European Pillar of Social Rights (2), proclaimed at Gothenburg on 17 November 2017, provides that every worker has the right to a healthy, safe and well-adapted working environment. The workers’ right to a high level of protection of their health and safety at work and to a working environment that is adapted to their professional needs and that enables them to prolong their participation in the labour market includes protection from exposure to biological agents at work. (2) The implementation of the directives related to the health and safety of workers at work, including Directive 2000/54/EC, was the subject of an ex-post evaluation, referred to as a REFIT evaluation. The evaluation looked at the directives’ relevance, at research and at new scientific knowledge in the various fields concerned. The REFIT evaluation, referred to in the Commission Staff Working Document (3), concludes, among other things, that the classified list of biological agents in Annex III to Directive 2000/54/EC needs to be amended in light of scientific and technical progress and that consistency with other relevant directives should be enhanced. -
“The Cellular Context of Rabies Virus Replication – Cell Culture Adaptation, Intra-Neuronal Virus Transport and Development of Host Gene Targeting Vectors”
“The Cellular Context of Rabies Virus Replication – Cell Culture Adaptation, Intra-Neuronal Virus Transport and Development of Host Gene Targeting Vectors” I n a u g u r a l d i s s e r t a t i o n zur Erlangung des akademischen Grades eines Doktors der Naturwissenschaften (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald vorgelegt von Sabine Nemitz geboren am 14.02.1989 in Rathenow Greifswald, den 20.07.2018 1 Dekan: Prof. Dr. Werner Weitschies 1. Gutachter : PD Dr. Stefan Finke 2. Gutachter: Prof. Dr. Karl-Klaus Conzelmann Tag der Promotion: 05.12.2018 2 3 I. Table of Content I. Table of Content 4 II. List of Abbreviations 7 III. Publications 10 1. SUMMARY 11 2. INTRODUCTION 15 2.1. Classification 16 2.2. Transmission 18 2.3. RABV virion structure and genome organization 19 2.4. RABV proteins 21 2.5. Life cycle 26 2.6. Neuronal transport of RABV particles 28 2.7. Fixed and non-fixed RABV 30 2.8. RABV as vector and research tool 31 2.8.1. Gene regulation via post-transcriptional silencing: RNAi 32 2.8.2. Cytoplasmically replicating RNA viruses as vectors for shRNA synthesis 34 3. AIMS OF THE STUDY 35 4. MATERIAL 36 4.1. Technical equipment 36 4.2. Chemicals 36 4.3. Antibiotics 36 4.4. Standard buffers 37 4.5. Marker 38 4.6. Kits 38 4.7. Cell lines 38 4.8. Cell culture media 39 4.9. Bacteria 41 4.10. Viruses 41 4.11. -
Rhabdoviridae.Pdf
1 Rhabdoviridae Taxonomy Realm- Ribovira Kingdom- Orthornavirae Phylum- Negarnaviricota Subphylum-Haploviricotina Class- Monjiviricetes Order- Mononegaviriales Family- Rhabdoviridae Genus- Lyssavirus Genus-Ephemerovirus Rhabdoviridae: The family Derivation of names Rhabdoviridae: from rhabdos (Greek) meaning rod, referring to virion morphology. Member taxa Vertebrate host Lyssavirus Novirhabdovirus Perhabdovirus Sprivivirus Tupavirus Vertebrate host, arthropod vector Prepared by Dr. Vandana Gupta Page 1 2 Curiovirus Ephemerovirus Hapavirus Ledantevirus Sripuvirus Tibrovirus Vesiculovirus Invertebrate host Almendravirus Alphanemrhavirus Caligrhavirus Sigmavirus Plant host Cytorhabdovirus Dichorhavirus Nucleorhabdovirus Varicosavirus The family Rhabdoviridae includes 20 genera and 144 species of viruses with negative-sense, single-stranded RNA genomes of approximately 10–16 kb. Virions are typically enveloped with bullet-shaped or bacilliform morphology but non-enveloped filamentous virions have also been reported. The genomes are usually (but not always) single RNA molecules with partially complementary termini. Almost all rhabdovirus genomes have 5 genes encoding the structural proteins (N, P, M, G and L); however, many rhabdovirus genomes encode other proteins in additional genes or in alternative open reading frames (ORFs) within the structural protein genes. The family is ecologically diverse with members infecting plants or animals including mammals, birds, reptiles or fish. Rhabdoviruses are also detected in invertebrates, -
Sandfly Virus Seroconversion Associated with Neurologic Presentation
Sandfly virus seroconversion associated with neurologic presentation Chen Makranz, MD* ABSTRACT * Hiba Qutteineh, MD Objective: To describe the clinical presentation and unique neurologic manifestations of sandfly Hanna Bin, PhD viruses (SFVs) in the Jerusalem area. Yaniv Lustig, PhD Methods: We identified all patients with acute seroconversion to SFV at the Hadassah-Hebrew John Moshe Gomori, MD University Medical Centers during the years 2008–2013 and retrospectively collected and ana- Asaf Honig, MD lyzed the clinical and imaging data. Abed El-Raouf Bayya, MD Results: Nine patients (ranging from 1.5 to 85 years old) were identified. Presentation included acute Allon E. Moses, MD neurologic disease, mostly with fever, change in consciousness and behavior, seizures, headache, Tamir Ben-Hur, MD, meningitis, limb paresis, or myelitis. Eight patients had clinical signs of meningitis, meningoencephali- PhD tis, or encephalitis alone. Four patients had myelitis. MRI identified pathologic symmetrical changes in Diana Averbuch, MD the basal ganglia, thalami, and other deep structures in 5 patients, and additional myelitis of the spine Roni Eichel, MD was noted on imaging in 3 patients. Seven patients had long-term follow-up: 4 completely recovered Ran Nir-Paz, MD and 3 had remaining neurologic sequelae, among them 1 with permanent severe brain damage. Conclusion: Neurologic involvement associated with acute SFV infections is considered to be benign. However, in this series, all 9 patients presented with significant neurologic pathology Correspondence to associated with a unique finding of myelitis and symmetrical basal ganglia, thalami, or white mat- Dr. Nir-Paz: [email protected] ter involvement. Thus, acute SFV infection should be included in the differential diagnosis in feb- rile onset of neurologic manifestations and neuroradiologic changes.