Text-Mining of Top 50 Differentially Regulated Genes Top 50 Gene Candidate at a 5% FDR (Base Mean, Log2 Fold Change and P-Adjusted Values Are Specified)

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Supplementary Table 1: Text-mining of top 50 differentially regulated genes Top 50 gene candidate at a 5% FDR (base mean, log2 fold change and p-adjusted values are specified). Manual text-mining was performed for each candidate. Categories were established considering available information for cell compartment, biological function, region of expression and mammal orthologues data.

ensembl_gen external_gen baseM log2FoldC pad region_expression categor source link e_id e_name ean hange j y

ENSDARG000 trim101 223.26 - 4.9 skeletal_muscle muscle zfin http://zfin.org/ZDB-GENE-040801-100 00018264 6953 3.4205734 2E- 25

ENSDARG000 ckmt2b 68.327 - 1.7 skeletal_muscle muscle zfin http://zfin.org/ZDB-GENE-040426-1654 00039929 9066 1.2735683 9E- 05

ENSDARG000 zbtb4 141.48 - 4.1 mesoderm muscle zfin https://zfin.org/ZDB-GENE-100318-5 00061827 0592 1.0032933 6E- 09

ENSDARG000 pigt 61.665 - 1.3 somite muscle zfin https://zfin.org/ZDB-GENE-090313-46 00075842 6557 0.8932759 3E- 05

ENSDARG000 arhgap4a 38.061 - 1.1 neural_tissue neural zfin - http://zfin.org/ZDB-GENE-040426-1229 https://omim.org/entry/300023?search=ar

00039265 6206 1.8567648 8E- OMIN hgap4&highlight=arhgap4 08

ENSDARG000 her4.2 692.15 - 1.2 neural_tissue neural zfin http://zfin.org/ZDB-GENE-060815-1 00094426 7419 1.4117474 3E- 12

ENSDARG000 acer1 112.08 - 9.5 neural_tissue neural zfin http://zfin.org/ZDB-GENE-050417-70 00010347 7892 1.2215564 4E- 07

ENSDARG000 her4.3 564.22 - 4.1 neural_tissue neural zfin https://zfin.org/ZDB-GENE-081030-7 00070770 1021 1.1805975 9E- 05

ENSDARG000 pfkfb1 214.42 - 1.1 neural_tissue neural zfin https://zfin.org/ZDB-GENE-030131-5664 00037140 707 0.8844084 9E- 11

ENSDARG000 ldb2b 250.60 - 1.3 neural_tissue neural zfin https://zfin.org/ZDB-GENE-990415-137 00034896 9608 0.6198509 3E- 05

ENSDARG000 CCDC115 524.30 - 3.2 neural_tissue neural zfin - https://zfin.org/ZDB-GENE-050227-20 https://omim.org/entry/613734 00033533 3483 0.4989453 9E- OMIN 05

ENSDARG000 cspg5a 829.92 - 1.0 neural_tissue neural zfin - https://zfin.org/ZDB-GENE-080425-4 https://omim.org/entry/606775 00069981 6292 0.4933447 4E- OMIN 05

ENSDARG000 fez1 524.99 - 1.5 neural_tissue neural zfin https://zfin.org/ZDB-GENE-040426-2723 00023174 7667 0.4801264 4E- 06

ENSDARG000 sncgb 353.49 - 2.6 neural_tissue neural zfin https://zfin.org/ZDB-GENE-050522-235 00076081 3441 0.4567478 3E- 05

ENSDARG000 rnd1 448.57 0.9092914 6.3 neural_tissue neural zfin https://zfin.org/ZDB-GENE-040630-6 00030547 6717 3 7E- 08

ENSDARG000 BAALC 88.368 1.2893966 1.0 neural_tissue neural zfin - https://zfin.org/ZDB-GENE-081022-24 https://omim.org/entry/606602 00089549 7299 1 3E- OMIN 09

ENSDARG000 ttll10 138.53 1.9688732 7.3 neural_tissue neural zfin https://zfin.org/ZDB-GENE-081104-350 00090472 3229 3 0E- 23 ENSDARG000 CABZ010155 47.508 - 4.0 vascular_tissue neural Institute http://angiogenes.uni- 00091235 25.1 5214 3.4152642 1E- and of frankfurt.de/transcript?search=&rows_per_pag

05 cardiova Cardiova e_int=25&page_number=546 scular scular Regener ation, Goethe Universit y Frankfurt

ENSDARG000 ppp1r14c 5.5429 - 2.6 neural_cardiac_tissue neural OMIN https://omim.org/entry/613242 00054817 2909 5.4382032 9E- and 05 cardiova scular

ENSDARG000 sla2 23.469 - 9.4 immune_system neural zfin - http://zfin.org/ZDB-GENE-080204-98 https://omim.org/entry/606577 00020788 3679 2.3799544 5E- and OMIN 11 cardiova scular

ENSDARG000 CU571255.1 47.132 - 5.2 cardiac_skeletal_muscle neural zfin https://zfin.org/ZDB-GENE-041111-277 00089920 9575 1.2207048 2E- and 06 cardiova scular

ENSDARG000 rbp7b 985.09 - 1.5 neural_cardiac_muscle_tis neural zfin https://zfin.org/ZDB-GENE-081022-134 00070486 2104 0.9525541 7E- sue and 06 cardiova scular

ENSDARG000 rgs5a 164.56 - 2.0 vascular_tissue neural zfin https://zfin.org/ZDB-GENE-030131-7570 00002644 8151 0.6718394 6E- and 06 cardiova scular

ENSDARG000 gng2 366.31 - 1.7 neural_vascular_tissue neural zfin https://zfin.org/ZDB-GENE-050417-59 00056831 8584 0.5695759 9E- and 05 cardiova scular

ENSDARG000 sult6b1 1349.5 - 1.3 neural_vascular_tissue neural zfin https://zfin.org/ZDB-GENE-050417-228 00086826 1741 0.5633785 5E- and 12 cardiova scular

ENSDARG000 ca6 1780.8 - 2.4 neural_vascular_tissue neural zfin https://zfin.org/ZDB-GENE-030131-7091 00056499 7737 0.5397003 6E- and 09 cardiova scular

ENSDARG000 slc12a3 493.85 - 5.3 neural_cardiac_gut neural zfin https://zfin.org/ZDB-GENE-030131-9505 00013855 4667 0.5100772 1E- and 06 cardiova scular

ENSDARG000 lama4 1142.4 - 3.0 cardiac_vascular_tissue neural zfin https://zfin.org/ZDB-GENE-040724-213 00020785 4679 0.4982175 9E- and 05 cardiova scular

ENSDARG000 kalrnb 505.63 - 1.3 blood neural zfin https://zfin.org/ZDB-GENE-060421-7244 00063538 8601 0.4433807 1E- and 05 cardiova scular

ENSDARG000 kdm6bb 1769.3 - 1.1 neural_cardiac_vascular_ti neural zfin https://zfin.org/ZDB-GENE-040724-166 00056929 2634 0.4381307 6E- ssue and 06 cardiova scular

ENSDARG000 rca2.1 1170.4 - 1.2 neural_cardiac_gut neural zfin https://zfin.org/ZDB-GENE-050320-60 00056075 6545 0.3794535 4E- and 06 cardiova scular

ENSDARG000 krt18 16821. 0.5366186 3.3 cardiac_vascular__tissue_ neural zfin https://zfin.org/ZDB-GENE-030411-6 00018404 7388 4 2E- pharyngeal_arch and 05 cardiova scular

ENSDARG000 rca2.2 43.343 1.4741692 3.0 neural_cardiac_liver_tissu neural zfin https://zfin.org/ZDB-GENE-060503-646 00095512 1095 9 4E- e and 09 cardiova scular

ENSDARG000 bgnb 49.991 1.7607725 1.1 neural_cardiac_vascular_ti neural zfin - https://zfin.org/ZDB-GENE-040426-21 https://omim.org/entry/300989 00002945 9093 7 1E- ssue and OMIN 09 cardiova scular

ENSDARG000 dnajc5ab 1423.2 0.3938746 8.1 neural_testis_tissue neural zfin - https://zfin.org/ZDB-GENE-081021-2 https://omim.org/entry/611203?search=dn

00004836 6869 7 7E- and OMIN ajc5&highlight=dnajc5 09 reproduc tive

ENSDARG000 spsb1 570.75 0.5379064 2.7 neural_muscle_ovary_testi neural zfin https://zfin.org/ZDB-GENE-030131-6122 00056515 2435 6 1E- s and 08 reproduc tive

ENSDARG000 dnase1l3 710.50 - 1.5 neural_tissue_blood_phary neural, zfin https://zfin.org/ZDB-GENE-040808-35 00005464 1878 0.7709107 3E- ngeal_arch blood 05 and pharyng eal arches

ENSDARG000 CR762484.3 272.88 - 3.9 neural_tissue_hematopoiet neural, zfin https://zfin.org/ZDB-GENE-000804-1 00089489 2325 0.6017719 3E- ic blood 10 and

pharyng eal arches

ENSDARG000 dnmt5 924.31 0.3627808 1.3 neural_tissue_blood_phary neural, zfin https://zfin.org/ZDB-GENE-050314-2 00057863 5763 9 1E- ngeal_arch blood 05 and pharyng eal arches

ENSDARG000 oard1 162.83 - 5.4 other zfin http://zfin.org/ZDB-GENE-050522-480 00057426 978 2.2705516 1E- 39

ENSDARG000 ociad2 98.655 - 3.9 other zfin https://zfin.org/ZDB-GENE-041014-253 00052336 3524 1.0976163 5E- 09

ENSDARG000 esyt1a 381.76 - 8.3 spleen_adipose_tissue other zfin - https://zfin.org/ZDB-GENE-090311-55 https://omim.org/entry/616670 00034714 1581 0.7463954 7E- OMIN 08

ENSDARG000 pa2g4b 7279.5 - 1.6 other zfin https://zfin.org/ZDB-GENE-030131-2182 00070657 0801 0.5600499 4E- 06

ENSDARG000 rps26 8956.1 0.3952103 4.6 other zfin https://zfin.org/ZDB-GENE-030131-8606 00037071 6534 7 5E- 06

ENSDARG000 gdi1 2743.8 0.5841122 4.4 other zfin https://zfin.org/ZDB-GENE-050522-504 00056122 4085 7 1E- 12

ENSDARG000 slc16a12a 153.26 0.9022992 1.6 other zfin https://zfin.org/ZDB-GENE-080721-24 00017773 096 5 4E- 06

Supplementary Table 2: Gene set enrichment analysis. Analysis was performed by converting zebrafish gene names to human gene names using exclusively genes with a one-to-one ortholog relationship. The number of resulting genes identifiers analyzed was 9128 out of 33737 (Genome build Zv9, Ensembl annotation released version 79). Adjusted p-values were calculated per category. Normalized Enrichment Score (NES) of gene sets with a FDR of 5% (blue dots) and 15% (purple dots) were plotted to summarized GSEA results.

pathway pval padj ES NES nMoreExtreme size leadingEdge gene_set