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Running Enrichment Score (RES) −1.5 −1.0 −0.5 0.0 0 "G1[B_Nov]" "G1[B_Nov]" 2000 Number ofgenes: 12930(inlist),30geneset) Gene Set1734:PROTEASOME Zero crossingat6822 4000 Gene ListIndex 6000 Peak at9598 Peak 8000 10000 "G2[Non_B_Nov]" "G2[Non_B_Nov]" 12000 P(ES) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 −1.0 Neg. ES "G2[Non_B_Nov]" Neg. ES"G2[Non_B_Nov]" ES = −0.678 NES = −1.43 Nom. p−val= 0.165FWER=1FDR=0.315 ES =−0.678NES =−1.43Nom.p−val= −0.5 Gene SetNullDistribution 0.0 ES Observed GeneSetESvalue Gene SetNullDensity Pos. ES: "G1[B_Nov]" ES:"G1[B_Nov]" Pos. 0.5 1.0 PSMD14 PSMD11 PSMD13 PSMD12 PSMB3 PSMD4 PSMD2 PSMA3 PSMD7 PSMA7 PSMC6 PSMB5 PSMA4 PSMB1 PSMB6 PSMC5 PSMA6 PSMB4 PSMD8 PSMB2 PSMA5 PSMD6 PSMC1 PSMC4 PSMA1 PSMC2 PSMA2 PSMC3 PSMB7 PSMD3 Class G1[B_Nov] JD0396.ALL.v5.U133A.CEL JD0108.ALL.v5.U133A.CEL JD0146.ALL.v5.U133A.CEL JD0360.ALL.v5.U133A.CEL JD0367.ALL.v5.U133A.CEL JD0314.ALL.v5.U133A.CEL JD0420.ALL.v5.U133A.CEL JD0343.ALL.v5.U133A.CEL JD0173.ALL.v5.U133A.CEL JD0258.ALL.v5.U133A.CEL JD0287.ALL.v5.U133A.CEL JD0181.ALL.v5.U133A.CEL JD.ALD509.v5.U133A.CEL JD0239.ALL.v5.U133A.CEL JD0186B.ALL.v5.U133A.CEL JD0032.ALL.v5.U133A.CEL JD0361.ALL.v5.U133A.CEL JD0336.ALL.v5.U133A.CEL JD0300.RR.ALL.v5.U133A.CEL JD0267.ALL.v5.U133A.CEL JD0323.ALL.v5.U133A.CEL JD0150.ALL.v5.U133A.CEL JD0059.ALL.v5.U133A.CEL JD0123.ALL.v5.U133A.CEL JD0056.ALL.v5.U133A.CEL JD0058.ALL.v5.U133A.CEL JD0139.ALL.v5.U133A.CEL JD0107.ALL.v5.U133A.CEL JD0109.ALL.v5.U133A.CEL GenesinGeneSet HeatMapfor JD0085.ALL.v5.U133A.CEL JD0253.ALL.v5.U133A.CEL JD0426.ALL.v5.U133A.CEL JD0286.ALL.v5.U133A.CEL JD0282.ALL.v5.U133A.CEL JD0318.ALL.v5.U133A.CEL JD.ALD096.v5.U133A.CEL JD.ALD108.v5.U133A.CEL JD0066.ALL.v5.U133A.CEL JD0016.ALL.v5.U133A.CEL JD0048.ALL.v5.U133A.CEL JD0086.ALL.v5.U133A.CEL JD0193.ALL.v5.U133A.CEL JD0280.ALL.v5.U133A.CEL JD0320.ALL.v5.U133A.CEL JD0330.ALL.v5.U133A.CEL JD0328.ALL.v5.U133A.CEL JD0250.ALL.v5.U133A.CEL JD0220.ALL.v5.U133A.CEL JD0332.R.ALL.v5.U133A.CEL JD0304.ALL.v5.U133A.CEL JD0395.ALL.v5.U133A.CEL G2[Non_B_Nov] JD0341.ALL.v5.U133A.CEL JD0263.ALL.v5.U133A.CEL JD0364.ALL.v5.U133A.CEL JD0437.ALL.v5.U133A.CEL JD0436.ALL.v5.U133A.CEL JD0382.ALL.v5.U133A.CEL JD0354.ALL.v5.U133A.CEL JD0342.ALL.v5.U133A.CEL JD0238.ALL.v5.U133A.CEL JD0247.ALL.v5.U133A.CEL JD0168.B.ALL.v5.U133A.CEL JD0264.ALL.v5.U133A.CEL JD0390.ALL.v5.U133A.CEL JD0423.ALL.v5.U133A.CEL JD0432.ALL.v5.U133A.CEL JD0344.ALL.v5.U133A.CEL JD0039.ALL.v5.U133A.CEL JD0255.ALL.v5.U133A.CEL JD0297.R.ALL.v5.U133A.CEL JD0421.ALL.v5.U133A.CEL JD0408.ALL.v5.U133A.CEL JD.ALD057.v5.U133A.CEL JD.ALD232.v5.U133A.CEL JD.ALD294.v5.U133A.CEL JD.ALD385.v5.U133A.CEL JD0080.ALL.v5.U133A.CEL JD.ALD052.v5.U133A.CEL JD.ALD078.v5.U133A.CEL JD.ALD433.v5.U133A.CEL JD0084.ALL.v5.U133A.CEL swp350.u133a.CEL JD.ALD180.v5.U133A.CEL JD0124.ALL.v5.U133A.CEL JD0284.ALL.v5.U133A.CEL JD.ALD009.v5.U133A.CEL JD0349.ALL.v5.U133A.CEL JD0185B.ALL.v5.U133A.CEL JD0103.ALL.v5.U133A.CEL JD0425.ALL.v5.U133A.CEL JD0225.ALL.v5.U133A.CEL JD0433.ALL.v5.U133A.CEL JD0431.ALL.v5.U133A.CEL JD0252.ALL.v5.U133A.CEL JD0188.ALL.v5.U133A.CEL JD0272.ALL.v5.U133A.CEL JD0289.ALL.v5.U133A.CEL JD0407.ALL.v5.U133A.CEL JD0257.ALL.v5.U133A.CEL JD0095.ALL.v5.U133A.CEL JD0226.ALL.v5.U133A.CEL JD.ALD388.v5.U133A.CEL JD.ALD428.v5.U133A.CEL JD0154.ALL.v5.U133A.CEL JD.ALD494.v5.U133A.CEL JD.ALD035.v5.U133A.CEL JD.ALD039.v5.U133A.CEL JD.ALD391.v5.U133A.CEL JD.ALD264.v5.U133A.CEL JD.ALD386.v5.U133A.CEL JD.ALD387.v5.U133A.CEL JD.ALD389.v5.U133A.CEL JD.ALD390.v5.U133A.CEL JD.ALD008.v5.U133A.CEL JD0206.ALL.v5.U133A.CEL JD0102.ALL.v5.U133A.CEL JD0129.ALL.v5.U133A.CEL JD.ALD613.v5.U133A.CEL JD0192.ALL.v5.U133A.CEL JD0260.ALL.v5.U133A.CEL JD0036.ALL.v5.U133A.CEL JD0381.ALL.v5.U133A.CEL JD0291.RR.ALL.v5.U133A.CEL JD0203.ALL.v5.U133A.CEL JD0246.ALL.v5.U133A.CEL JD0274.ALL.v5.U133A.CEL JD0334.ALL.v5.U133A.CEL.