VIAL-MATE Adaptor Only for Powdered Single Dose Drug Vials with 20 Mm Closures and VIAFLEX SINGLE PACK Containers Sterile, Nonpyrogenic See Directions for Use

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BAXTER CONFIDENTIAL PROOFREADING APPROVAL/RELEASED ARTWORK Check as applicable PROOFREADING APPROVAL/RELEASED ARTWORK Check as applicable INTERNAL USE ONLY Printed Name Excluding Printed Name Excluding dimensions dimensions *This artwork requires that the supplier insert a Data Matrix ECC 200 (2D) bar code master Excluding Excluding in the position indicated. Bar code must match human readable on art and on spec. Do not Document No.: 07-03-76-748 bar code bar code dimensions dimensions alter human readable information on art. Bar code must conform to all applicable Baxter Signature Date Signature Date Change No.: CP0841735 U.S. English U.S. English specifications. Page 1 of 1 Other Language: Other Language: BLACK PMS 287C PMS 369C PMS 185C ______P2 21-MAR-2016 TJJ Qty: 50 For Product Information Baxter, Viaflex and Vial-Mate are trademarks of Baxter International Inc. Baxter Healthcare Corporation Deerfield, IL 60015 USA Made in USA ONLY POSITION BAR CODE (91) 070376748 UNVARNISHED AREA FOR ONLINE PRINTING UNVARNISHED VIAL-MATE Adaptor Only for powdered Single Dose Drug Vials with 20 mm Closures and VIAFLEX SINGLE PACK Containers Sterile, Nonpyrogenic See directions for use. For single use only. Do not resterilize. This product is not made with natural rubber latex. Rx Only Symbol for "STERILIZED USING IRRADIATION". 1-800-933-0303 2B8071 DISPENSER PACK

2B8071 Qty:Qty: 50 50 2B8071 Qty: 50 2B8071 Qty:Qty: 50 50 2B8071 Qty: 50

VIAL-MATE Adaptor Adaptor UPN85412027388 (ea.) VIAL-MATE Adaptor VIAL-MATE Adaptor Adaptor UPUPN85412027388N85412027388 (ea.)(ea.) VIAL-MATE Adaptor Only forfor powderedpowdered Single Single Dose Dose Drug Drug Vials Vials with with 20 mm20 mm Closures Closures and VIAFLEXand VIAFLEX SINGLE SINGLE PACK ContainersPACK Containers Only for powdered Single Dose Drug Vials OnlyOnly forfor powderedpowdered Single Single Dose Dose Drug Drug Vials Vials with with 20 mm20 mm Closures Closures and VIAFLEXand VIAFLEX SINGLE SINGLE PACK PACKContainers Containers Only for powdered Single Dose Drug Vials ASSEMBLY - Use ONLY with SINGLE PACK 5% Dextrose or 0.9% Sodium Chloride in 50, 100 or 250 mL VIAFLEX Containers. Do not use with VIAFLEX Multi-Pack Containers. with 20 mm Closures and VIAFLEX ASSEMBLY - Use ONLY with SINGLE PACK 5% Dextrose or 0.9% Sodium Chloride in 50, 100 or 250 mL VIAFLEX Containers. Do not use with VIAFLEX Multi-Pack Containers. with 20 mm Closures and VIAFLEX

1 Foil Lid 2 3 4 SINGLE PACK Containers 1 Foil Lid 2 3 4 SINGLE PACK Containers Flange Collar Flange Collar Port Adaptor Rib Blue Port Adaptor Port Adaptor Rib Blue Port Adaptor

Vial Gripper Rib Vial Gripper Rib White Vial Gripper White Vial Gripper Medication Administration Medication Administration port port Do not use with VIAFLEX Ensure flange collar port port Do not use with VIAFLEX Ensure flange collar multi-pack containers touches the container multi-pack containers touches the container Use aseptic technique to assemble • Remove vial To attach the VIAL-MATE Adaptor to the • Pull the vial straight down to ensure vial is • Hold the VIAL-MATE adaptor just beneath the flange collar Use aseptic technique to assemble • Remove vial To attach the VIAL-MATE Adaptor to the • Pull the vial straight down to ensure vial is • Hold the VIAL-MATE adaptor just beneath the flange collar • Peel open blister pack cover and drug vial: securely attached - DO NOT TWIST vial in device • Push the container medication port straight into the VIAL-MATE • Peel open blister pack cover and drug vial: securely attached - DO NOT TWIST vial in device • Push the container medication port straight into the VIAL-MATE DO NOT USE IF FOIL SEAL IS COMPROMISED disinfect vial • Place vial upright • Remove foil lid - area under foil lid is sterile port adaptor until the flange collar touches the container DO NOT USE IF FOIL SEAL IS COMPROMISED disinfect vial • Place vial upright • Remove foil lid - area under foil lid is sterile port adaptor until the flange collar touches the container stopper • Hold white vial gripper • Disinfect medication port on SINGLE PACK stopper • Hold white vial gripper • Disinfect medication port on SINGLE PACK • Firmly push vial gripper straight down until VIAFLEX container • Firmly push vial gripper straight down until VIAFLEX container ACTIVATION vial snaps into place - DO NOT TWIST DO NOT USE WITH VIAFLEX MULTI-PACK CONTAINERS ACTIVATION vial snaps into place - DO NOT TWIST DO NOT USE WITH VIAFLEX MULTI-PACK CONTAINERS See either side panel for directions for use. See either side panel for directions for use. 5 6 For single use only. For single use only. 5 6 For single use only. For single use only. Use only with the following SINGLE PACK Use only with the following SINGLE PACK

Starting position 5% Dextrose or 0.9% Sodium Chloride Use only with the following SINGLE PACK 5% Dextrose Starting position 5% Dextrose or 0.9% Sodium Chloride Use only with the following SINGLE PACK 5% Dextrose VIAFLEX Containers: VIAFLEX Containers:

Single Pack 50, 100, 250 mL or 0.9% Sodium Chloride VIAFLEX Containers: Single Pack 50, 100, 250 mL or 0.9% Sodium Chloride VIAFLEX Containers: Do not use with VIAFLEX Multi-Pack Containers Do not use with VIAFLEX Multi-Pack Containers Single Pack 50, 100, 250 mL Single Pack 50, 100, 250 mL

Do not over-twist Ribs aligned Over-twisted Not for use with VIAFLEX Multi-Pack Containers. Do not over-twist Ribs aligned Over-twisted Not for use with VIAFLEX Multi-Pack Containers. • Hold the white vial gripper and blue port adaptor Detail showing “starting position” and “ribs aligned” • Push the blue port adaptor assembly into the white vial • Hold the white vial gripper and blue port adaptor Detail showing “starting position” and “ribs aligned” • Push the blue port adaptor assembly into the white vial assemblies firmly states of VIAL-MATE device gripper until the flange collar meets the white vial gripper assemblies firmly states of VIAL-MATE device gripper until the flange collar meets the white vial gripper • Twist slightly to align the ribs of the blue port Note: alignment of ribs in its “unlocked” state DO NOT PULL BLUE PORT ADAPTOR BACK OUT OF THE • Twist slightly to align the ribs of the blue port Note: alignment of ribs in its “unlocked” state DO NOT PULL BLUE PORT ADAPTOR BACK OUT OF THE adaptor and the white vial gripper DO NOT OVER-TWIST WHITE VIAL GRIPPER AFTER RECONSTITUTION adaptor and the white vial gripper DO NOT OVER-TWIST WHITE VIAL GRIPPER AFTER RECONSTITUTION RECONSTITUTION ADMINISTRATION RECONSTITUTION ADMINISTRATION Indications for Use: • Remove container administration port protector • Remove container administration port protector 7 8 9 • Attach administration set per its directions 7 8 9 • Attach administration set per its directions To provide the pharmacist or health practitioner a means of • Hang container on I.V. pole and prime set per directions • Hang container on I.V. pole and prime set per directions Ensure that vial is empty of drug and solution Ensure that vial is empty of drug and solution connecting a standard 20 mm single dose drug vial to an Repeat step 8 if drug and solution remain in vial Repeat step 8 if drug and solution remain in vial WARNING: DO NOT USE IN SERIES CONNECTIONS WARNING: DO NOT USE IN SERIES CONNECTIONS I.V. solution container without mixing the vial contents with • Administer medication per directions • Administer medication per directions the diluent until immediately before administration of the Use within specified time for drug stability Use within specified time for drug stability Refer to drug package insert Refer to drug package insert reconstituted drug to the patient. Ensure flange collar Do not pull blue port adaptor back out of the Ensure flange collar Do not pull blue port adaptor back out of the touches the container white vial gripper after Reconstitution. touches the container white vial gripper after Reconstitution. • Hold bag with vial down • Hold bag with vial upside down • Repeat steps 7 and 8 until vial is empty of drug • Hold bag with vial down • Hold bag with vial upside down • Repeat steps 7 and 8 until vial is empty of drug • Squeeze bag to force solution into vial until half full • Squeeze bag to force air into vial and solution is thoroughly mixed • Squeeze bag to force solution into vial until half full • Squeeze bag to force air into vial and solution is thoroughly mixed • Shake to suspend drug in solution • Release to drain suspended drug from vial DO NOT REMOVE VIAL-MATE ADAPTOR AND Rx Only • Shake to suspend drug in solution • Release to drain suspended drug from vial DO NOT REMOVE VIAL-MATE ADAPTOR AND Rx Only Ensure drug is completely dissolved DRUG VIAL Ensure drug is completely dissolved DRUG VIAL

07-03-76-748 07-03-76-748 REV 2016-04-01 REV 2016-04-01