Annual REPORT 2004 - 2005

University of Toronto Cardiovascular Sciences Collaborative Program

VELUT ÆVO ARBOR

FitzGerald Bldg., 150 College Street, Room 83D, Toronto ON M5S 3E2 Tel: 416/978-0746 Fax: 416/946-5713 E-mail: [email protected] Web site: www.cscp.utoronto.ca

CONTENTS

Director’s Report ...... 4

Mission Statement ...... 6

Collaborating Departments ...... 6

Committees ...... 7 - Executive - Program

Courses Offered ...... 7

Program Sponsored Activities ...... 8 - Annual Student Research Day - Student Forum Night - Human Biology Job Fair - Summer Program

Awards ...... 12 - Medtronic Travel Award - Bigelow Book Prize - Lorne Phenix Graduate Award - Ontario Student Opportunity Trust Funds (OSOTF) Award - Ontario Graduate Scholarships in Science and Technology (OGSST) - Life Sciences Committee Summer Undergraduate Research Fellowships

Advertising Material ...... 15

Acknowledgements ...... 15

Students ...... 16 - Currently Enrolled - Convocated/Follow-Up - Awards

Faculty ...... 21 - Members - Awards and Honors - Peer Reviewed Funding

Publications ...... 42 - Students - Faculty

~ ~ DIRECTOR’S REPORT

This past year has been one of great sadness but also a year of new and creative directions.

We said good-bye to a great leader in the cardiovascular field and friend of the CSCP, Dr. Wilfred ‘Bill’ Bigelow, who died this past spring. His legacy and memory will live on in the “Bigelow Book Prize” that we have given out since 1995. He will be missed!

However, it is with pride to see how much we have evolved since the Program’s inception. Specifically, we were invited to present the CSCP to the Council of Health Sciences and Social Work Deans where the Program received resounding endorsement. This resulted in the Program becoming even more multidisciplinary and encompassing with all relevant Faculties (Dentistry, Nursing, Pharmacy and Social Work) planning to sign the MOA as part of the CSCP. As this will have a dramatic impact on all aspects of our activities, we will be busy revisiting our education mandate to be sure that all our partners are well served by the Program. This new initiative is fully multidisciplinary and captures the essence of the University’s “Stepping Up Program” as well as the Faculty of Medicine’s “Academic Plan”, providing further linkages both within and across various disciplines within the University of Toronto. To that end, it is clear that the new cardiovascular graduate initiative will ultimately supersede the CSCP.

Parallel to this, a joint initiative with the University of Waterloo continues to be under discussion and I anticipate exciting times ahead for cardiovascular graduate education at the University of Toronto. Linkages with the University of Waterloo will further enrich the students’ experience and we will be utilizing state-of-the-art distance learning tools such as web casting and other e-learning media.

Last year the JCV series graduate courses were rendered more web-based with the course’s seminars and notes mounted on our password protected course section of the CSCP website. One class was actually web cast and if funding applications are successful, we anticipate these courses will be fully web cast.

Our students continue to work hard and congratulations to them for all their successfully organized events on behalf of the CSCP including a very successful “Annual Student Research Day”, “Student Forum and Dinner”, and “Circulation Rounds”.

In this academic year we had 23 Masters and 16 PhD trainees in the Program (see graph below).

~ ~ Our annual student interviews reiterate a high degree of satisfaction. They have expressed particular enthusi- asm for the expansion of the Program into the other Faculties as it is their contention that is enriches the interaction they have with a diverse group of trainees from varied backgrounds. This past year also saw a number of our students completing their graduate training and going on to pursue either academic or research careers (see Convocated section), which has affected our totals for student numbers. This will be addressed with our upcoming student recruitment initiative. As part of our ongoing tradition, bound copies of each graduating student’s thesis continue to be kept in the Program office (total: 44 MSc/MaSc and 22 PhD).

For the 2005-2006 academic year we plan to continue our current activities and pursue the following priorities:

• Develop innovative curriculum to more appropriately serve the diverse nature of this now multi-Faculty graduate training initiative • Continue developing endowments to provide permanent infrastructure support • Establish and launch the joint initiative with the University of Waterloo • Aggressive student recruitment • Graduate training grant applications for both local and external agencies • Further develop CME programs in cardiovascular sciences • Continue developing web-based courses and web casting

As you read through this report, you will see that the Program continues to grow and enrich our trainee’s experiences. Specific details on all activities can be found on our web site at www.cscp.utoronto.ca. I would like to once again recognize the outstanding efforts of Victoria Simpson, our Business Officer, as well as the Executive Committee for their hard work and contributions that have made the Cardiovascular Sciences Collaborative Program the success it is today. And finally, I would like to take this opportunity to thank all our faculty and students for another successful year and to those individuals who have continued to provide both moral and tangible support for this Program.

I continue to be proud to present this Annual Report that summarizes the achievements of the Program’s students and faculty over the past academic year.

Dr. Carin Wittnich, O.Ont. Director, CSCP Professor of Surgery & Physiology Northrop Frye Scholar

~ ~ MISSION STATEMENT

“The Cardiovascular Sciences Collaborative Program, approved by the University and Ontario Council on Graduate Studies in 1992, and listed in the calendar of the School of Graduate Studies, exists to give formal, organized expression to cardiovascular studies and research at the graduate level. It builds on the strengths of all participating academic units, and other agencies, to enhance the visibility of cardiovascular studies and to facilitate collaborative, interdisciplinary training and research.”

The above mission is achieved by advertising and promoting the importance of, and opportunities in, cardiovascular studies, by making known the results of such studies, by recruitment of excellent students, and by coordinating the graduate collaborative program in cooperation with the academic units in which they are registered. Students in this collaborative program must fulfill the requirements of their home units as well as the Program. Upon graduation the notation “Specialization in Cardiovascular Sciences” will appear on the student’s academic transcript and the Program will present the student with a certificate and gift.

COLLABORATING FACULTIES Medicine Physical Education and Health

COLLABORATING GRADUATE UNITS Department of Exercise Sciences Department of Health Policy, Management & Evaluation Department of Laboratory Medicine and Pathobiology Department of Medical Biophysics Department of Pharmacology Department of Physiology Department of Public Health Sciences Department of Rehabilitation Science Institute of Biomaterials and Biomedical Engineering Institute of Medical Science

SUPPORTING CLINICAL DEPARTMENTS Department of Anesthesia Department of Medicine Department of Surgery

~ ~ COMMITTEES

Executive The Executive Committee consists of 4 members of the Program Committee representing as wide a range of disciplines as possible and includes the Director. They also act as Chairs of the various subcommittees as detailed in the Director’s Report. The Executive Committee provides student counseling, screens applicants, provides advice and acts as a Steering Committee. Meetings are held as needed.

Dr. C. Wittnich (Fundraising) Dr. M. Rand (Scholarships & Awards) Dr. S. Thomas (Student Affairs) Dr. V. Rao (Membership)

Program The Program Committee consists of a representative from each collaborating department as well as two student representatives. It administers the Program, selects the Director, and generally meets twice per year.

C. Wittnich (Chair) M. Borger (Department of Surgery) D. Brooks (Rehabilitation Science) D. Mazer (Anesthesia) R.I. Ogilvie (Pharmacology) M. Ojha (Institute of Biomaterials and Biomedical Engineering) M. Rand (Laboratory Medicine and Pathobiology) V. Rao (Institute of Medical Science) S. Thomas (Exercise Sciences) R. Tsushima (Physiology) J. Tu (Health Policy, Management and Evaluation) G. Wright (Medical Biophysics) President, CSCP Student Association Vice-President, CSCP Student Association

COURSES OFFERED

EXS5508H Cardiovascular Disease and Exercise JCV3060H* Advanced Topics in Cardiovascular Sciences – Molecular Biology & Signal Transduction JCV3061H* Advanced Topics in Cardiovascular Sciences – Hormones in the Cardiovascular System JCV3062H* Advanced Topics in Cardiovascular Sciences – Heart Function JCV3063H* Advanced Topics in Cardiovascular Sciences – Vascular JEB1365H Ultrasound: Theory and Applications in Biology and Medicine JTC1331H Biomaterials Science LMP1015H Vascular Pathobiology LMP1504H Cell and Molecular Biology of Cardiovascular Diseases PSL1060H Developmental Cardiovascular Physiology PSL1462H Molecular Aspects of Cardiac Function

* Core Courses for PhD Trainees (2 of 4 modules required); JCV denotes joint listing with most of our collaborating departments. ~ ~ Suggested Courses (Considered valuable but does not fulfill Program requirements)

CHL5201 Introducing Biostatistics for Students in Biological Sciences LMP1404S Cellular and Molecular Mechanisms of Disease PSL1052H Fundamentals on Ion Channel Function

PROGRAM SPONSORED ACTIVITIES

Annual Student Research Day 2005 The Cardiovascular Sciences Collaborative Program held its 6th Annual Student Research Day on February 16, 2005. All CSCP trainees were in attendance. The morning session began with a retreat where the Student Association highlighted activities from the past year as well as upcoming events. Selected trainees presented their research concepts, designs or results in a series of 10-minute presentations followed by a question period. The presentations were especially polished and professional this year, and covered a broad range of hot topics.

SESSION I: Chair -- Ali Pourdjabbar Erin Butler (MSc – Institute of Medical Sciences) “Quantitated Cell Engraftment and Functional Myocardial Assessment Following Post-acute Myocardial Infarction Injection of Endothelial Progenitor Cells” Danny Quaglietta (MSc – Physiology) “Effects of Oxygen Stress in the Neonate” Adam Gwozdz (MSc – Institute of Medical Sciences) “Platelet Procoagulant Surface Expression” Grace Chan (MSc – Physiology) “The Role of Interferon-Beta in the Reversal of Fibrosis Induced by Myocarditis” John Sun (MSc – Physiology) “Pre- and Postnatal Cardiovascular Changes in a Growth-Restricted Mouse Model” SESSION II: Chair -- Warren Foltz Golnaz Karoubi (PhD – Biomedical Engineering) “Microencapsulation-Implications for Cell Therapy to the Lung” Eser Adiguzel (PhD – Laboratory Medicine and Pathobiology) “The Role of Type VIII Collagen in Vascular Smooth Muscle Cell Migration” Danny Ramzy (PhD – Institute of Medical Sciences) “Elevated Levels Of Endothelin-1 Impairs Nitric Oxide Bioavailability: Role of Protein Kinase C” Elizabeth Frey (MSc – Exercise Sciences) “The Effects of Prolonged Exercise on Left Ventricular Function in Middle-Aged and Older Male Recreational Athletes” Michael Ward (PhD – Institute of Medical Sciences) “Genetically Modified Endothelial Progenitor Cells for the Enhancement of Neovascularization”

~ ~ Prior to lunch, winners of the Bigelow Book Prize, Karim Bandali, and the Phenix Graduate Award, Rachel Mitchell were announced. We were honoured to have Dr. Bigelow and Kathryn Phenix, daughter of Mrs. Phenix, present to hand out the awards.

Certificates and gifts were presented to students who had successfully completed the Cardiovascular Sciences Collaborate Program.

Pictured: Sandra Merklinger, PhD and Dr. Carin Wittnich, CSCP Director

After the award ceremony, the meeting broke for lunch.

The afternoon consisted of an informal presentation by two leading cardiovascular scientist/clinicians, Dr. Donna Stewart, Chair of Women’s Health at UHN and U of T and Dr. Fred Keeley, Professor of Biochemistry and Laboratory Medicine & Pathobiology. The presentations were followed by a lively discussion in which students had an opportunity to discuss the trials and tribulations of living a life devoted to education and research with these highly respected and successful individuals.

~ ~ The Student Research Day met with resounding success. This day would not have been possible without the efforts of the Planning Committee:

Chair: Patricia Rose Members: Eser Adiguzel Christina Whelan Michael Ward Advisor: Golnaz Karoubi

The committee also gratefully acknowledges the educational grant from Aventis Pharma and the support of Victoria Simpson in making this a very successful day.

Congratulations on a job well done!!

Debate Night This exciting event was organized for the cardiovascular community and was attended by diverse members of the university community, including graduate students, medical students, undergraduate students, faculty as well as a strong attendance by the research community. The goal of the debate night is to provide graduate students with the chance to learn and form their own opinions in delicate subject matters that challenge the scientific community. It also provides faculty an opportunity to voice their point-of-view and to allow other levels of trainees to appreciate the issues concerning the community.

The debate was held on March 29, 2005 in the Debates Room at Hart House where the audience participated in “Be it resolved that in the increasingly stressed healthcare system, greater emphasis should be placed on prevention of heart diseases rather than on the development of novel therapies”. Dr. Thomas Parker chaired the debate, which included discussions on many levels. Dr. Cameron Mustard (Public Health Sciences) made very strong arguments for the importance of behavioral prevention, using many historical and epidemiological arguments. While unable to disagree with Dr. Mustard about the importance of disease prevention, Dr. David Alter (Institute for Clinical Evaluative Sciences) focused on the priority of the healthcare system, with limited resources, in treating the sick as well as possible. The debate included discussion regarding the role of government, academia, biomedical research and ethics in what is a very complex discussion.

Thank you to Bristol-Myers Squibb for their generous support of an education grant helping us make this a successful event.

Student Forum Night The 3rd Annual CSCP Student Forum and Dinner was held on Wednesday, December 6, 2004 at the Chestnut Residence. Established to provide CSCP students a social highlight at the end of the year, the trainees discussed the selected topic in a forum round table setting. This year’s topic of “MSc vs. PhD: Are we letting just anyone get a PhD and is the MSc an extinct degree?” appeared to be close to the heart of most all students in attendance. The relaxed and informal setting allowed for candid conversation, which the majority found beneficial. A few senior members of the CSCP program were able to shed some light onto the value of completing a MSc first before proceeding to train for their PhD, while other MSc-PhD transfer students provided their honest advice in the reasoning of by-passing the MSc degree. Current MSc students shared their thoughts and reasons for pursuing an MSc at the moment. The evening was a great success where open and candid discussions about the students’ concerns regarding their current and future states were addressed. Furthermore, it

~ 10 ~ was noted that the event was highly beneficial to some junior attendees in searching for their ideal academic career path. The value of the event and the work of the organizing committee was well received. The evening’s program was followed by a festive dinner.

Women’s Cardiovascular Health The Cardiovascular Sciences Collaborative Program participated in the Centre for Research in Women’s Health Annual General Meeting on November 23, 2004 with a display table. Various students in the Collaborative Program manned a table and provided information to attendees. Thanks to Clifford Lin for setting this up.

CSI: Toronto (Cardiovascular Summer Initiative) This year’s Annual Cardiovascular Sciences Collaborative Summer Program was revamped. CSCP graduate students showcased their research work and discussed the practical aspects of research to the students. Summer students also participated by presenting their own work. This was particularly beneficial as it gave the students an opportunity to try out their presentation skills in an informal, non-judgmental environment. Helpful feedback was given and the students were able to discuss the skills they were learning in greater detail.

The student’s visited the Toronto Rehabilitation Institute’s Cardiac Centre (Rumsey Centre). They sat in on an introduction/orientation session with new patients and received a tour of the facility. In addition, they also got the opportunity to meet and interact with the patients about their experiences and got a first hand look at the benefits of cardiac rehabilitation. Thank you to Rob Bertelink at the Centre for making this an exciting aspect of the Program. A second field trip was organized to the Toronto Western Hospital, Retinal Blood Flow Lab. Students served as subjects for demonstrations of state of the art instruments like the Retinal Thickness Analyser, Laser Blood Flowmeter, and the Optical Coherence Tomographer.

Thanks to Pat Rose for organizing such an interesting and successful program.

~ 11 ~ CSI Agenda: 10 June Mini-symposium 1 Erin Butler Healing the broken heart: progenitor cells Adam Gwozdz Platelets & apoptosis Grace Chan Pathophysiology of viral myocarditis Dan Quaglietta Newborn development & response to oxygen stress

8 July Mini-symposium 2 Albert Tsui Hemodilutional anemia & cerebral blood flow Mark Ormiston “Sugar Coated” cells for cardiovascular therapy Mila Kisilevsky Autonomic dysfunction

13 July Field Trip: Toronto Rehab, Rumsey Centre

5 Aug Mini-symposium 3 Rami Bishay Echocardiography & cardiac graft rejection Tetyana Bodnaruk Neuraminidase & smooth muscle cell proliferation John Sun Heart structure and function in small babies

12 Aug Field Trip: Toronto Western Hospital, Retinal Blood Flow Lab

19 Aug Student presentations/Certificate presentations

AWARDS

Medtronic Travel Award Two competitions were held (spring and fall) for the Medtronic Travel Award. This award, established in 1995, helps to defray costs of travel for Program students presenting their research work at recognized scientific meetings. Students supported by this award this academic year were:

Fall 2004: Ali Pourdjabbar, MSc, Institute of Medical Science: “Losartan and Acute Myocardial Infarction in Insulin Resistant Zucker Fatty Rats: Reduced Ventricular Arrhythmias and Improved Survival” and “The Effects of Pre-Peri-and Post Myocardial Infarction Treatment with Losartan in Rats: The Effects of Dose on Survival, Ventricular Arrhythmias, Function and Remodelling”, Canadian Cardiovascular Society Annual Meeting (Supervisor: Dr. T. Parker) Nazneen Tata, MSc, Department of Physiology: “Remodeling in the Vasculature: Diurnal Gene Expression in Normal vs. Diseased Murine Aorta”, Canadian Cardiovascular Society Annual Meeting (Supervisor: Dr. M. Sole)

Spring 2005: Rachel Mitchell, MSc, Institute of Medical Science: “Depression in Women Improves After Coronary Artery Bypass Graft Surgery”, American College of Cardiology (Supervisor: Dr. D. Stewart) John Sun, MSc, Department of Physiology: “Transgenic Mice Overexpressing Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1) in the Liver Pre-and Postnatally Show Cardiac Morphological and Functional Changes”, Society for Gynecologic Investigation (Supervisor: Dr. L. Adamson)

~ 12 ~ Pat Rose, PhD, Institute of Medical Science: “Variability of Retinal Arteriolar and Venular Blood Flow During Isocapnec Hyperoxia in Normal Subjects”, Society of Vascular Medicine and Biology (Supervisor: Dr. C. Hudson)

Bigelow Book Prize This prize was established in 1995 by the Cardiovascular Sciences Collaborative Program to recognize and honor a pioneer clinician and scientist in the field of cardiovascular sciences. Awardees should exemplify the personal traits of Dr. Bigelow - curiosity, drive, and scientific integrity. The award is given in every year that a qualified student is identified. Qualifications include sustained academic scientific excellence, innovative experimental approaches, original discoveries and good scientific productivity. Some weight is given to work that has recognizable clinical relevance, especially that which promises to improve patient care. The Bigelow Book Prize consists of 2 books written by Dr. W.G. Bigelow entitled “Cold Hearts” and “Mysterious Heparin” and a keeper plaque created to honor Dr. Bigelow. Appropriate candidates are identified and the final decision is made by the Program Committee. This award is presented at the Annual Student Research Day and we were extremely pleased that Dr. Bigelow was once again able to participate in this years’ award ceremony and interact with the trainees.

1995 – Dr. John S. Ikonomidis 1996 – Ms. Shona M. Torrance 1997 – Dr. Vivek Rao 1998 – Dr. Bryce Cowan 1999 – Dr. Gideon Cohen 2000 – Dr. Michael Borger 2001 – Dr. Saeid Babaei 2002 – Mr. Wm. Jack Wallen 2003 – Dr. Paul W.M. Fedak 2004 – Dr. Nathalie Lapointe 2005 – Dr. Karim Bandali

Karim Bandali received his PhD from the Department of Physiology. His research focused on children undergoing corrective heart surgery who are often exposed to high oxygen levels (hyperoxia). Since oxygen is essential to life, its potentially detrimental effects when administered in excess are rarely considered. Karim’s Ph.D. thesis showed that exposure to hyperoxia can lead to the development of a variety of detrimental metabolic and functional cardiovascular complications in the newborn in an experimental setting. These novel findings have significant implications in the clinical use of hyperoxia which impact on pediatric cardiac patient care. After completing his PhD, Karim joined The Michener Institute for Applied Health Sciences as a member of the faculty and an associate researcher. L-R: Dr. Karim Bandali, Dr. Wilfred Bigelow, Dr. Margaret Rand

~ 13 ~ Lorne Phenix Graduate Award This award was made possible by a generous donation in the memory of Mr. Lorne Phenix by Mrs. Geraldine Phenix. It is her hope that this award will focus attention on the issue of heart disease – which is still the #1 killer of both men and women in Canada. In addition, women who have heart problems are at least equal if not at greater risk than men and Mrs. Phenix hopes that this award will serve to encourage trainees to pursue this area of research to address this particular problem. It is awarded to a graduate student in the Faculty of Medicine on the basis of research and academic excellence. The award consists of a cash prize and certificate and is presented to the recipient at the Annual Student Research Day. Appropriate candidates are identified and a winner is selected by a subcommittee chaired by Dr. Donna Stewart. This award is presented at the Annual Student Research Day.

2001 – Wm. Jack Wallen, PhD 2002 – Wm. Jack Wallen, PhD 2003 – Shathiyah Kulandavelu, PhD 2004 – Rachel Mitchell, MSc

Rachel Mitchell is an MSc candidate in the Institute of Medical Science. Her research is on the differences between men and women undergoing coronary artery bypass graft (CABG) surgery with a focus on mental health and depression. Approximately 30% of the 500,000 CABG procedures performed a year in North America are on women, who are thought, by some to fare worse. Rachel’s research followed men and women undergoing elective CABG surgery to try to get a better understanding of depression patterns and how they differ. Her work found that women were more depressed than men before surgery but improved to a level comparable to men after surgery, even after controlling for other relevant factors. This work has important implications and suggests that depression should not preclude women from CABG surgery. Upon completion of her MSc, Rachel hopes to attend medical school and pursue a L-R: Rachel Mitchell, Dr. Margaret Rand, career as a clinician/scientist with a special interest in Ms. Kathryn Phenix women’s health.

Ontario Student Opportunity Trust Funds (OSOTF) Award The OSOTF award refers to a class of awards that have resulted from the Ontario government’s “matching” program. Under the program every dollar of donation received for student assistance has been matched by the government as well as the university on a dollar-for-dollar basis. The Cardiovascular Sciences Collaborative Program participates in this program. There are two major conditions for all OSOTF awards; recipients must be Ontario residents and demonstrate financial need. However, the Program has additional eligibility criteria that must be adhered to, including excellence in science and academic performance. One competition is held per academic year.

~ 14 ~ The applications are handled centrally through the Office of the Associate Dean, Inter-Faculty and Graduate Affairs. Applications pertaining to the CSCP are sent to us and are then adjudicated by a subcommittee chaired by Dr. Margaret Rand. Committee recommendations are then forwarded to the OSOTF Awards Committee (Faculty of Medicine). This year’s recipients were Nesime Askin, PhD, Physiology; Rami Bishay, MSc, Physiology, and Danny Quaglietta, MSc, Physiology

Ontario Graduate School Science and Technology (OGSST) The OGSST program is designed to encourage excellence in graduate studies in science and technology. The program is supported through funds provided by the Ministry of Training, Colleges and Universities and by funds raised by the University of Toronto and the Heart & Stroke Foundation of Ontario. To be awarded to graduate students at the University of Toronto who are pursuing cardiovascular/stroke research. Students must have maintained an overall A- average over the last two years of study at the post-secondary level and exhibit research ability/potential, good communication skills and interpersonal/leadership abilities.

2004-2005 Awardees

Name Degree Dept. Supervisor Cathy Boscarino PhD PSL J. Coles Peter Sabatini MSc LMP L. Langille I. Eser Adiguzel PhD LMP M. Bendeck Bernard Ho MSc LMP M. Bendeck Christopher Kim MSc PSL B. McCrindle Adam Gwozdz MSc IMS M. Rand Steven Gu MSc PSL S. Heximer Danny Quaglietta MSc PSL C. Wittnich Nesime Askin PhD PSL C. Wittnich

ADVERTISING MATERIAL

The Cardiovascular Sciences Collaborative Program maintains and updates its web site (www.cscp.utoronto. ca) on a regular basis. Faculty information is updated whenever we are notified of relevant changes. This year Victoria Simpson revamped the entire website look to optimize efficient use by visitors. The Program students took an active part in creating their own sections, including short bios on each student, course summaries/ surveys to help other students pick courses suitable for their needs, and they are working on a bulletin board section to keep everyone updated on cardiovascular activities. Collaborating departments are encouraged to provide hypertext links to the Collaborative Program on their web site.

The Program distributes brochures at the various campus activities and the collaborating departments are encouraged to have links with the CSCP’s web site and distribute brochures.

ACKNOWLEDGEMENTS:

The Cardiovascular Sciences Collaborative Program would like to thank the following industry sponsors for their generous support: Biovail Pharmaceuticals Canada; Bristol-Myers Squibb Company; and Medtronic Canada.

~ 15 ~ STUDENTS

Name Supervisor Degree Department I. Eser Adiguzel M. Bendeck PhD LMP Nesime Askin C. Wittnich PhD PSL Rami Bishay L. West MSc PSL Tetyana Bodnaruk A. Hinek MSc IMS Erin Butler T. Parker MSc IMS Kirsteen Burton G. Tomlinson MSc CHL (inactive status) Grace Chan P. Liu MSc PSL Elizabeth Frey J. Goodman MSc EXS Adam Gwozdz M. Rand MSc IMS Golnaz Karoubi D. Courtman PhD BME Mila Kisilevsky C. Hudson MSc IMS Shathiyah Kulandavelu L. Adamson PhD PSL Clifford Lin D. Courtman MaSc BME Vaska Micevski D. Stewart PhD IMS (inactive status) Santiago Miriuka V. Rao MSc IMS Rachel Mitchell D. Stewart MSc IMS Maureen Mountford C. Wittnich MSc PSL Brooke Murphy A. Hinek MSc LMP Mark Ormiston D. Courtman PhD BME Danny Quaglietta C. Wittnich MSc PSL Danny Ramzy V. Rao MSc IMS Sonja Reichert J. Goodman MSc EXS (inactive status) Patricia Rose C. Hudson PhD IMS Renee Suen D. Stewart PhD IMS John Sun L. Adamson MSc PSL Nazneen Tata M. Sole MSc PSL Shona Torrance C. Wittnich PhD IMS (inactive status) Albert Tsui G. Hare MSc PSL Michael Ward D. Stewart PhD IMS Christina Whelan S. Thomas MSc EXS Liana Zucco D. Stewart MSc LMP

Convocated Students/Follow-Up

David Ashburn, MSc, Institute of Medical Science (Supervisor: Dr. J. Coles) “Utility of Competing Risks in Analyzing Outcomes of Repair of Congenital Heart Defects” (Cardiothoracic Surgery, Michigan)

~ 16 ~ Asim Cheema, PhD, Institute of Medical Science (Supervisor: Dr. B. Strauss) “Arterial Repair After Baloon Angioplasty and Stenting: Role of Matrix and Microvessels” (Cardiology Staff Physician, St. Michael’s Hospital, Toronto)

Sandra Merklinger, PhD, Institute of Medical Science (Supervisor: Dr. M. Rabinovitch) “Progression and Regression of Pulmonary Vascular Disease Related to Smooth Muscle Cell Apoptosis, S100A4/Mts1 and Fibulin-5” (Cardiovascular Research, Hospital for Sick Children, Toronto)

Ali Pourdjabbar, MSc, Institute of Medical Science (Supervisor: Dr. T. Parker, Dr. J. Rouleau) “The Effect of Angiotensin II Receptor Blockade, Prior to, During and After a Myocardial Infarction in Rats With and Without Insulin Resistance” (Medical School)

William Jack Wallen, PhD, Department of Physiology (Supervisor: Dr. C. Wittnich) Sex-Hormones Modulate Whole-Body and Myocardial Responses in Both Wistar-Kyoto and Spontaneously Hypertensive Rats” (Medical School – University of Toronto)

Angela Wang, MSc, Institute of Medical Science (Supervisor: Dr. R-K Li) “Effect of Estrogen on Angiogenic Factor Expression in Cultured Uterine Cells” (Medical School)

Note: Should discrepancy arise between total number of students enrolled and number convocated can be accounted for students that are incomplete or terminate graduate studies.

~ 17 ~ Awards and Honors Eser Adiguzel OGSST – Heart & Stroke Foundation of Ontario Meredith & Malcolm Silver Scholarship in Cardiovascular Sciences

Nesime Askin OGSST – Heart & Stroke Foundation of Ontario

Rami Bishay Department of Physiology Fellowship, UofT

Tetyana Bodnaruk Institute of Medical Science Entry Award, UofT Institute of Medical Science Continuing Fellows Award, UofT Ontario Graduate Scholarship, UofT

Erin Butler Open Fellowship Award, UofT OGSST Open Fellowship Award, UofT

Adam Gwozdz OGSST – Heart & Stroke Foundation of Ontario Graduate of Ontario Student Opportunity Trust Funds Award, Restracomp, Hospital for Sick Children

Golnaz Karoubi Ontario Graduate Scholarship, UofT Kennan Fellowship & Studentship Award

Shathiyah Ontario Graduate Scholarship, UofT Kulandavelu

Clifford Lin NSERC Postgraduate Scholarship, UofT

Santiago Miriuka Trainee Award for best Basic Science Abstract, Canadian Society of Transplantation Annual Meeting, Alberta Research Grant: Effects of immunosupressors on endothelial progenitor cells, Wyeth

Rachel Mitchell Centers for Disease Control and Prevention Travel Award, American Heart Association, Second International Conference on Women, Heart Disease and Stroke Lorne Phenix Graduate Award, Cardiovascular Sciences Collaborative Program, UofT

Brooke Murphy University of Toronto Fellowship

Mark Ormiston PGS-A Scholarship, NSERC

Danny Quaglietta OGSST – Heart & Stroke Foundation of Ontario Department of Physiology Open Fellowship, UofT

Danny Ramzy Thoracic Surgery Foundation for Research and Education Research Fellowship Nellie L. Farthing Fellowship, UofT William S. Fenwick Fellowship, UofT Chisholm Memorial Fellowship, UofT Patty Rigby and John Wedge Graduate Scholarships in Science and Technology, UofT ~ 18 ~ Patricia Rose Vision Science Research Program Scholarship, UofT Heart & Stroke Foundation of Canada Doctoral Studentship Award, UofT AAO Student Travel Fellowship, American Academy of Optometry Sandra & David Smith Award, Vision Science Research Program, UofT Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT

Renee Suen Pfizer/CHS/CIHR RxD Doctoral Research Award

John Sun School of Graduate Studies Open Fellowship Award, UofT Research Training Centre Travel Award, Samuel Lunenfeld Research Institute, Mount Sinai Hospital President’s Presenter Award, Society for Gynecologic Investigation OBGYN Scholarships in Science & Technology, Government of Ontario/Pharmacia Canada Inc./Genesis Research Foundation Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT

Nazneen Tata Department of Physiology, Open Fellowship, UofT Medtronic Travel Award, Cardiovascular Sciences Collaborative Program, UofT HSRLCE Studentship Award, UofT

Albert Tsui UofT Open Fellowship Dr. James A. & Connie P. Dickson Scholarship in the Sciences & Mathematics G.H. Ferguson Scholarship

Michael Ward CIHR Jessie Boyd & Charles Scriver MD/PhD Studentship

Liana Zucco University of Toronto Fellowship

Publications Delgado DH, Miriuka SG, Cusimano RJ, Feindel C, Rao V, Ross HJ: Use of basiliximab and cyclosporine in heart transplant patients with preoperative renal dysfunction. J Heart Lung Trans, 2005;24(2):166-169.

Fedak PWM, Rao V, Verma S, Ramzy D, Tumiati L, Miriuka S, Boylen P, Weisel RD, Feindel CM: Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation. J Thorac Cardiovasc Surg, 2005;129(2):407-415.

Miriuka SG, Langman J, Evrovski J, Miner SES, et al: Genetic polymorphisms predisposing to hyperhomo- cysteinemia in cardiac transplant patients. Transplant International, 2005;18(1):29-35.

Leytin V, Allen DJ, Gwozdz A, Garvey B, Freedman J: Role of platelet surface GPIba and P-selectin in the clearance of transfused platelet concentrates. Transfusion, 2004;44:1488-1496.

Liu PP, Fuse K, Chan G, Liu Y, Opavsky A: Viral myocarditis: From pathophysiology to the clinic. IN: Braunwald’s Heart Failure. Eds: Schultheiss HP, Poller W. Springer Verlag, 2004.

~ 19 ~ Liu PP, Chan G, Fuse K, Liu Y: Immunomodulatory Therapies in Heart Failure. IN: Viral Myocarditis as a Paradigm. Ed: Feldman AM. Blackwell Publications, 2005.

Ramzy D, Rao V, Tumiati LC, Ning X, Miriuka S, Delgado D, Ross HJ: Tetrahydrobiopterin prevents cyclosporine-induced vasomotor dysfunction. Transplantation, 2005;79(8):876-881.

~ 20 ~ FACULTY

Members Faculty are divided into 3 categories (Full, Associate, Affiliate). Details on faculty research interests and contact information are available on the web site. Departmental affiliations listed are those within the CSCP.

Name Departmental Affiliation(s) Location Full Lee Adamson BME/IMS/PSL Mount Sinai Hospital Khosrow Adeli LMP Hospital for Sick Children Peter Backx IMS/Medicine/PSL UofT – HSRLCE Jaques Belik IMS/PSL Hospital for Sick Children Michelle Bendeck LMP/Medicine UofT – MSB Douglas Bradley IMS/Medicine Toronto General Hospital Dina Brooks REH UofT – Rehabilitation Science John Coles IMS/Surgery Hospital for Sick Children Philip Connelly LMP/Medicine St. Michael’s Hospital David Courtman BME/Surgery St. Michael’s Hospital Paul Dorian IMS/Medicine/PCL St. Michael’s Hospital C. Ross Ethier BME UofT – Mechanical Engineering John Flanagan IMS Toronto Western Hospital John S. Floras IMS/Medicine Mount Sinai Hospital Christopher Forrest IMS/Surgery Hospital for Sick Children Stephen Fremes IMS/Surgery SWCHSC – Sunnybrook Adria Giacca PSL UofT - MSB Jack M. Goodman EXS UofT - Physical Ed & Health Len S. Goodman EXS Def & Civil Inst Environ Med Avrum I. Gotlieb LMP Toronto General Hospital Aleksander Hinek IMS/LMP Hospital for Sick Children Chris Hudson IMS Toronto Western Hospital Mansoor Husain IMS/LMP/Medicine Toronto General Hospital K. Wayne Johnston BME/IMS/Surgery Toronto General Hospital Peter G. Kalman IMS/Surgery Community Fred Keeley LMP Hospital for Sick Children B. Lowell Langille LMP Toronto General Hospital Michelle Letarte MBP Hospital for Sick Children Gary F. Lewis IMS/Medicine Toronto General Hospital Ren-Ke Li IMS/LMP/Surgery Toronto General Hospital Peter Liu IMS/Medicine Toronto General Hospital Marius Locke EXS/CHL UofT – Physical Ed & Health Peter McLaughlin IMS/Medicine Toronto General Hospital Donald A.G. Mickle LMP/Surgery Toronto General Hospital David Naylor IMS/Medicine/CHL/Surgery UofT – MSB Heyu Ni LMP St. Michael’s Hospital Matadial Ojha BME/Surgery UofT – Rosebrugh Bldg. John Parker IMS/Medicine Mount Sinai Hospital

~ 21 ~ Tom Parker IMS/Medicine Toronto General Hospital Margaret Rand IMS/LMP Hospital for Sick Children Vivek Rao IMS/Surgery Toronto General Hospital Michael Sefton BME UofT – Wallberg Bldg. Craig Simmons BME UofT – Mechanical Engineering Arthur S. Slutsky IMS/Medicine/Surgery Mount Sinai Hospital Michael J. Sole IMS/Medicine/PSL Toronto General Hospital Donna E. Stewart Anesthesia/IMS/Surgery/Medicine Toronto General Hospital Duncan Stewart IMS/LMP/Medicine St. Michael’s Hospital Bradley Strauss LMP/Medicine St. Michael’s Hospital Scott G. Thomas EXS/PSL UofT – Physical Ed & Health George Tomlinson CHL Toronto General Hospital Robert Tsushima IMS/Medicine/PSL UofT - MSB Jack Tu HPME SWCHSC - Sunnybrook Robert Wald IMS/Medicine Mount Sinai Hospital Richard D. Weisel IMS/Surgery Toronto General Hospital Gregory Wilson IMS/LMP/PSL/Surgery Toronto General Hospital Carin Wittnich IMS/PSL/Surgery UofT - MSB Graham Wright MBP SWCHSC - Sunnybrook Tai-Wing Wu LMP Toronto General Hospital Erik L. Yeo IMS/Medicine Toronto General Hospital

Associate Joel Fisher Anesthesia Toronto General Hospital Gregory Hare PSL St. Michael’s Hospital Scott Heximer PSL UofT - MSB Jane Irvine CHL Toronto General Hospital Valery Leytin LMP St. Michael’s Hospital Tom Lindsay IMS/Surgery Toronto General Hospital Nisar A. Shaikh LMP Community Lori West IMS Hospital for Sick Children

Affiliate Michael Borger Surgery Toronto General Hospital Jagdish Butany LMP/Medicine Toronto General Hospital Chris M. Feindel Surgery Toronto General Hospital David Mazer Anesthesia St. Michael’s Hospital Patricia Murphy Anesthesia Toronto General Hospital Richard I. Ogilvie Medicine/PCL Toronto Western Hospital Len Schwartz Medicine Toronto General Hospital

~ 22 ~ Awards and Honors M. Borger Roscoe Reid Graham Department of Surgery Award, UofT

D. Brooks New Investigator Award, Canadian Institutes of Health Research Mentorship Award, Canadian Physiotherapy Association Recognition in Teaching Award, Department of Physical Therapy, UofT

J. Butany Vice President and President Elect, International Society for Cardiovascular Pathology Vice President and President Elect, Canadian Association of Pathologists Judge, Annual Cardiovascular Scientific Day, HSRLCE

R. Ethier Tier I Canada Research Chair in Computational Technology Faculty Teaching Award

J. Fisher 1st Prize: A New Method for Noninvasive Measurement of Cardiac Output During Spontaneous Breathing. Assoc of the Industry for Health Technologies and Univ. of Montreal

J.G. Flanagan Chair, Admittance Committee, Section 6 (Academic), American Academy of Optometry Glenn A Fry Award, American Optometric Foundation Keynote Speaker, Meeting of Deutsch Ophthalmologische, Germany Appointed to Technical Advisory Group for Glaucoma, Carl Zeiss Meditec Top Ranked Grant Application, Glaucoma Research Society of Canada

J. Floras Canada Research Chair (Tier 1) in Integrative Cardiovascular Biology Career Investigator Award, HSFO

C.R. Forrest W.K. Lindsay Research Supervisor Award 2004 Chairman, Plastic Surgery Research Council

A. Gotlieb J.B. Walter Teaching Award, Dept. of Laboratory Medicine and Pathobiology (shared with D. Templeton). Innovation in Undergraduate Teaching, Specialist Program in Pathobiology

C. Hudson Canadian Institutes of Health Research, New Investigator Director, Retinal Research, University Health Network

M. Husain Career Investigator Award: Molecular regulation of vascular smooth muscle cell proliferation and contractility. Heart & Stroke Foundation of Ontario Premier’s Research Excellence Award: Molecular regulation of vascular smooth muscle cell proliferation: The role of calcium pumps in atherosclerosis and hypertension. Government of Ontario Allan Bruce Robertson Young Investigator Award, Clinical Research Society of Toronto Member, Scientific Review Committee “Cardiovascular C”, Canadian Institutes of Health Research External Reviewer, Medical Research Council, United Kingdom

~ 23 ~ J. Irvine Faculty of Graduate Studies Teaching Award, York Univ.

G. Lewis Canada Research Chair, Tier 2

R-K Li Adjunct Scientist Cross Appointment, St. Michael’s Hospital TGRI Space Committee Chair, Toronto General Research Institute, University Health Network, Toronto

P. Liu Visiting Professor Award, Royal College of Physicians & Surgeons of Canada 2005 American College of Cardiology Merit Award for Continued Excellence in Extramural Education Programs Distinguished CV Research Lecturer, UBC 2004 ` University Lecturer, University of Saskatchewan

M.L. Rand Member, Board of Directors, Heart & Stroke Foundation of Ontario

V. Rao Alfredo and Teresa DeGasperis Chair in Surgical Management of Heart Failure, University Health Network, UofT

C.A. Simmons William Gies Award, IADR/AADR, Best Biomaterials/Bioengineering paper pub- lished in the Journal of Dental Research for past year

A.S. Slutsky Elected to the Fleischner Society for Thoracic Imaging and Diagnosis at its Annual World Congress, Florence, Italy Recognition for Scientific Accomplishments, American Thoracic Society, San Diego, California

D.J. Stewart Associate Director Research, Basic Science, St. Michael’s Hospital Program Director, Regenerative Medicine, R. Samuel McLaughlin Centre for Molecular Medicine

B. Strauss Promotion to Full Professor, UofT

R. Tsushima New Investigator Award, Heart & Stroke Foundation of Canada Premier’s Research Excellence Award, Government of Ontario

J. Tu Career Investigator Award, Heart & Stroke Foundation of Ontario Renewal of Canada Research Chair in Health Services Research, Faculty of Medicine, UofT

R.D. Weisel Wilfred Bigelow Lectureship 2004 Award, Canadian Society of Cardiac Surgeons, Calgary, AB Distinguished Achievement Award, Council on Cardiovascular Surgery and Anesthesia, American Heart Association, New Orleans, LO Guest Lecturer, American Association for Thoracic Surgery, San Francisco, CA Director, Toronto General Research Institute, University Health Network

~ 24 ~ C. Wittnich Sustained Contribution to Excellence in Graduate Teaching, Graduate & Inter- Faculty Affairs Award, Faculty of Medicine, UofT Distinguished Alumni Award, Ontario Veterinary College, University of Guelph

Peer Reviewed Funding Alter D, Austin P, Tu JV (Co-Inv), Naylor CD, Mustard C, Irvine M, Morgan C, Wheaton B: Socioeconomic status and outcomes after acute myocardial infarction. CIHR, 2004 – 2007

Austin PC, Tu JV (Co-Inv), Alter DA, Stukel T, Naylor CD: Improving the accuracy of health ‘report cards’. CIHR, 2003 – 2005

Austin PC, Tu JV (Co-Inv), Naylor CD: Examining the accuracy of cardiac report cards. HSFO, 2003 – 2005

Backx P (PI), Husain M (Co-PI): Role of ACE2 in the regulation of cardiac and vascular function. CIHR Operating Grant, 2003 – 2008

Beanlands R (PI), Haddad H, Leech J, Burwash IG, Floras J, DaSilva J, deKemp RA (Co-Inv): Effects of continuous positive airway pressure on myocardial energetics and sympathetic nerve function in patients with heart failure and obstructive sleep apnea. HSFO, 2005 – 2007

Beattie WS, Rao V, Chan C: The PRIME (Perioperative Renal Insufficiency Management) study: A randomized, double-blind, placebo-controlled trial of N-Acetylcysteine for preventing renal injury after cardiac surgery. HSFC, 2003 – 2005

Belik, J (CoPI): Ventilator-induced lung injury: Linking gene expression, physiology and outcome (co- applicant). CIHR Operating Grant, 2003 – 2006

Belik J (Co-PI): Application of novel ultrasound techniques for basic and translational research models. CIHR Equipment Grant, 2004

Belik, J (PI): Airway modulation of pulmonary vascular tone during development and following pulmonary hypertension. CIHR Operating Grant, 2004 – 2009

Ivanov J, Borger MA, David TE, Tu JV (Co-Inv): A propensity score, pairmatched study of late outcomes for off-pump versus on-pump coronary artery bypass graft surgery. HSFC, 2004 – 2005

Borger MA, Djaiani G, Green RE, Ivanov J, Feindel CM: Minimal invasive cardiac surgery: Is it safe for the brain? HSFO, 2005 – 2007

~ 25 ~ Borger MA, David TE, Feindel CM: Clinical assessment of the BioPhysio valve. Edwards Lifesciences Inc., 2005 – 2007

Brodland W (PI), Ethier R: Measurement of biomechanical properties of the optic nerve with application to glaucoma. CIHR/NSERC Collaborative Health Research Program, 2004 – 2007

Brown TJ (PI), Letarte M (Co-Ap): Functional characterization of androgen-altered genes with a putative role during early events in ovarian carcinogenesis. CIHR Operating Grant, 2005 – 2009

Cheung AM, Liu P, Abramson B, Stewart DE: Clinical trial of Raloxifene use in the heart (RUTH). Eli Lilly, 1998 – 2007

Cohen G, et al… Wright GA (Col): Left ventricular mass regression following aortic valve replacement with stentless versus stended valves: Follow-up of a randomized trial delivery and tracking of stem cells in acute myocardial infarction. HSFC, 2004 – 2006

Connelly PW: Identification of the mechanisms of oxidation of high density lipoproteins in vivo in the mouse. HSFO, 2005

Connelly PW, Hanley AJ (PI): Longitudinal associations of adipocytokines and markers of sub-clinical inflammation with changes in insulin resistance and beta-cell function in women with a history of gestational diabetes mellitus. CIHR, 2004 – 2007

Courtman D, Stewart DJ: Arterial remodeling. HSFO, 2005 – 2007

Dennis CL (PI), Stewart DE (Co-Ap): An RCT to evaluate the effectiveness of peer support for PPD. CIHR, 2004 – 2007

Dick A, Wright GA, Stewart DJ: Delivery and tracking of stem cells in acute myocardial infarction. HSFO, 2004 – 2006

Ethier R (PI): Computational Hemodynamics. NSERC, 2005 – 2009

Ethier R (PI): Factors controlling aqueous outflow resistance in glaucoma. CIHR, 2001 – 2008

Ethier CR (PI), Flanagan JG (Co-Ap): Cell culture model of glaucoma using ischemia. Glaucoma Research Society of Canada, 2004

~ 26 ~ Ethier R (PI): Human anterior segment perfusion studies: Phase I Bausch and Lomb (contract), 2004 – 2005

Fan MZ, Liu Q, Mine Y, Yada R, Bakovic M, Li R-K (Co-Ap), Hellerstein M: Functionality of resistant starch and bioactive peptides in preventing chronic diseases and promoting gut functions in studies with the pig model. Ontario Ministry of Agriculture & Food, University of Guelph Food Research Program, 2004 – 2008

Fedak P, Butany J: Matrix remodeling and ascending aortic aneurysm. PSI, 2005

Feindel CM, Rao V: Hypertonic saline for cardiac transplantation. HSFO, 2004 – 2006

Feindel CM, Rao V: Preservation of endothelial function following prolonged storage of cardiac allografts with shed donor blood. HSFO, 2001 – 2004

Flanagan JG (PI): Diurnal changes in ocular perfusion, IOP and optic nerve topography. Glaucoma Research Society of Canada, 2001 – 2005

Flanagan JG (PI), Ethier R: Development of a hypoxic cell culture model of glaucoma. Glaucoma Research Society of Canada, 2004 – 2005

Flanagan JG (PI): The development of a sterile, universal, barrier systems for use with contact ophthalmic devices. Department of Health (UK), 2003 – 2004

Flanagan JG (PI), Ethier R (CoPI): The role of lamina cribrosa biomechanics and ischemia in glaucoma- tous optic neuropathy. CIHR, 2001 – 2006

Floras JS: Canada Research Chair (Tier I) in integrative cardiovascular biology. CIHR, 2004 – Present

Floras JS: Career Investigator Award. HSFO, 2001 – 2006

Floras JS (Prog Dir), Parker JD, Newton GE, Bradley TD, Chauhan VJ (Co-Aps): Multidisciplinary group for the investigation and therapy of human cardiovascular disease. HSFO Program Grant, 2003 – 2007

Floras JS: Cardiovascular regulation in men and women with heart failure and hypertension. HSFO, 2002 – 2007

Floras JS: Peptidergic and purinergic modulation of the autonomic nervous system in humans. CIHR Operating Grant, 2002 – 2007

~ 27 ~ Floras JS (PI), Bradley TD (Co-Inv): Cardiopulmonary interactions in health and disease. MRC, 2000 – 2005

Floras JS (PI), Chan C, Miller J, Pierratos A (Co-Inv): By what mechanisms does conversion from conventional intermittent dialysis to nocturnal hemodialysis lower blood pressure? CIHR, 2005 – 2008

Floras JS (PI), Chan D, Dzavik V, Bradley TD (Co-Inv): Cardiovascular, autonomic and neurohumoral impact of nocturnal hemodialysis. CIHR, 2005 – 2010

Forrest C, Gevorgyan A: Apoptosis in cultured calvarial cells following radiation. Plastic Surgery Educational Foundation, 2004 – 2005

Forrest CR, Gevorgyan AM: Bernd Spiessel Award 2004: Radiation-induced craniofacial bone growth retar- dations: Relationship between p53 expression, apoptosis and cell cycle arrest following radiation and cytoprotection in vitro. Am Soc Maxillofacial Surgeons, Synthes Maxillofacial Grants, 2004 – 2005

Freedman J (PI), Semple J, Lazarus A, Lau H, Ni H, Leytin V (Co-Inv): Investigations of novel mechanisms of IVIG function using a murine model of idiopathic thrombocytopenic purpura (ITP). Canadian IVIG Steering Committee, 2004 – 2005

Gagnon AJ (PI), Dennis C, Oxman-Martinez J, Stewart DE, et al (Co-PI’s): The childbearing health and related service needs of newcomers (CHARSNN). CIHR, 2004 – 2008

Gaisano HY (PI), Tsushima RG (Co-Inv): SNARE protein regulation of voltage-gated potassium channels in neurosecretory cells. CIHR, 2004 – 2007

Galipeau J, Liu P, Stewart DJ, Lansdorp PM, Karsan A, Megeney LA: Cardiovascular and respiratory stem cell plasticity – CARE project. CIHR, 2004 – 2009

Gevorgyan A, Forrest CR: Radiation induced craniofacial bone growth inhibition: In vitro investigation of the molecular mechanisms and cytoprotection. Am Soc Maxillofacial Surgeons, 2004 – 2005

Giacca A (PI): Metabolic determinants of vascular damage. HSFC, 2002 – 2005

Giacca A (PI): Anti-atherogenic effect of insulin. HSFC, 2005 – 2008

Giacca A (PI): Mechanisms of fatty acid induced insulin resistance. CDA, 2004 – 2006

~ 28 ~ Giacca A (PI): Interaction between lipotoxicity and glucotoxicity on glucose stimulated insulin secretion. CIHR, 2004 – 2007

Giacca A (Co-PI): Glucose toxicity: Prevention of compliations and preservation of beta cell function. CIHR, 2002 – 2007

Giacca A (Co-PI), Tsiani E: Investigation of the biological effects of the polyphenol resveratrol on skeletal muscle glucose transport. NSERC, 2004 – 2007

Gotlieb AI, Langille BL (Dir): Member, Cell Biology of Atherosclerosis Program Grant. HSFO Infrastructure Support, 2000 – 2005

Gotlieb AI, Langille BL (Co-PI’s): The endothelium in atherogenesis: Influences of hemodynamic stresses. HSFO, 2001 – 2006

Gotlieb AI, Bendeck M, (Co-PI): Heart valve repair: Regulation of cell and matrix. HSFO, 2002 – 2004

Gotlieb AI (Member), Deschepper C (Proj. Leader): Operational and ethical issues associated with banking human biologic materials. New Frontiers Program. CIHR, 2004 – 2005

Grace SL, Stewart DE (PI’s), Abramson B, Brooks D, Jaglal S, Scholey P, Suskin N, Arthur H, Evindar E (Co-App’s): An Evidence-Based Health Services Evaluation of Informational and Management Continuity in Heart Patients Canadian Health Services Research Foundation, 2003 – 2006

Grace SL, Stewart DE, Suskin A, Alter DA, Higginson L (Co-PI’s): Contribution of patient and physician factors to cardiac rehabilitation referral and participation: A prospective, multi-level study. CIHR, 2005 – 2008

Guidos CJ (PI), Letarte M (Co-Ap): Shared flow cytometry facility. CIHR Maintenance Grant, 2001 – 2006

Hakim A, Tu JV (Co-Inv), et al: Canadian Stroke Network. Networks of Centres of Excellence, 2000 – 2007

Henkelman M, et al…Wright GA: Medical imaging for cancer. NCI, Canada Program Project, 2001 – 2006

Hinek A (PI): Career Investigator Award HSFC, 2004 – 2007

Hinek A (Co-Inv), Liu P (PI): Aldosterone receptor and non-receptor based mechanism of repair and remodeling following cardiac injury. HSFC Operating Grant, 2004 – 2007

~ 29 ~ Hinek A (PI): Comparison of biological effects of different preparations of elastin-derived peptides on skin fibroblasts. Human Matrix Sciences Operating Grant, 2004 – 2006 Hudson C (PI): Pre-clinical detection, and improved monitoring, of early sight-threatening diabetic reti- nopathy. CIHR, New Investigator Award, 2001 – 2006

Hunter J, Barker K (Co-PI’s), Geruge S, McNally MJ, Stewart DE (Co-Ap’s): Cultural care patterns in a mobile health unit. Nursing Research Award, 2004 – 2005

Husain M (PI): c’Myb’dependent vascular smooth muscle cell proliferation. CIHR Operating Grant, 2001 – 2004 2004 – 2009

Husain M (PI): The role of plasma membrane Ca2+-ATPase isoforms in vascular smooth muscle cell biology. CIHR Operating Grant, 2003 – 2008

Husain M (PI): The role of plasma membrane Ca2+-ATPase isoforms in vascular pathophysiology. HSFO Operating Grant, 2003 – 2006

Irvine J (Co-Inv): Developing and testing a comprehensive telemanagement system to improve chronic disease treatment in primary health care: A demonstration project in diabetic patients with uncontrolled hypertension. OMH, Primary Health Care Transition Fund, 2005 – 2006

Irvine J (PI): Psychological support for patients with an implantable cardioverter defibrillator. HSFO, 2003 – 2006

Irvine J (Co-Inv): Sexual dysfunction and adaptation in couples affected by prostate cancer surgery: Steps towards a biopsychosocial model of treatment. CIHR, 2005 – 2008

Johnson M (PI), Ethier R (CoPI): The Hydrodynamics of Aqueous Humor Outflow NIH, 2004 – 2009

Johnston KW (PI), Ethier R (CoPI): Fundamental Ultrasound Studies CIHR, 2002 – 2006

Johnston KW (PI), Ethier R: Fundamental ultrasound studies. CIHR, 2002 – 2006

Johnson M (PI), Ethier R: The hydrodynamics of aqueous humor outflow. NIH (subgrant), 2004 – 2009

~ 30 ~ Karbouti K, Beattie WS, Rao V, Chan C, Ivanov J: The RICH (Renal Insufficiency in Cardiac Surgery: Role of Hemodilution) study. Earl Wynands Award in Cardiovascular Anaesthesis, 2004 – 2005

Keeley FW: Post-transcriptional regulation of vascular elastin synthesis in development and disease. CIHR Program Grant, 2001 – 2006 Keeley FW: Recombinantly expressed polypeptides of human elastin as a novel tool for investigations of the structure and assembly of elastin. HSFO, 2004 – 2009

Keeley FW (Co-Ap), Parkinson J: A combined theoretical/experimental approach to understanding sequence-structure-function relationships in elastin and elastin-like peptides. HSFO, 2005 – 2007

Keeley FW (Co-Ap), Wright GM: Characterization of extracellular matrix proteins in lamprey cartilage. NSERC, 2005 – 2010

Keeley FW: Production and characterization of human elastin polypeptides as vascular graft materials. Elastin Specialties, Inc, 2004 – 2006

Keith M, Stewart DJ: Does nutrient supplementation influence cardiac structure and function following MI by altering energy metabolism? CIHR, 2005 – 2007

Khan K, Gardam M, Slutsky AS, Jha P: Optimizing clinical and public health management of influenza- like-illnesses of undetermined etiology in a world changed by SARS. CIHR, 2004 – 2005

Langille BL (PI): Developmental arterial remodeling: Influence of shear stress. CIHR, 2000 – 2005

Langille BL, Gotlieb AI: Influence of hemodynamics on arterial endothelium. CIHR, 2001 – 2006

Langille BL (PI): Influence of hemodynamics on arterial endothelium. HSFO, 2002 – 2007

Langille BL (PI), Bendeck M: Cadherins and regulation of smooth muscle cell function. HSFO, 2004 – 2007

Langille BL (Director), Bendeck M, Courtman D, Cybulsky M, Gotlieb A, Heximer S, Husain M, Marsden P, Stewart D, Strauss B, Ward M: Cell biology of atherosclerosis. HSFO Group Grant, 2000 – 2005 2005 – 2010

Langille BL, Lye SJ (Director): Development and Fetal Health CIHR Group Grant, 2000 – 2005 2005 – 2010

~ 31 ~ Leask R, Butany J: Local tissue changes in dilated ascending aortas. NSERC – CHIR: Collaborative Heart Research Projects, 2005 – 2008

Leong-Pol H, Stewart DJ: Novel diagnostic and therapeutic applications of myocardial contrast echocardiography and targeted microbubbles for therapeutic angiogenesis. CIHR, 2003 – 2006

Letarte M (PI): Setting up protein microarray analysis of ovarian cancer. UHN Operating Grant, 2005 – 2006

Letarte M (PI): Structure and function of endoglin. CIHR Operating Grant, 2000 – 2005

Letarte M (PI): The role of endoglin in the normal vasculature and in the pathology of hereditary hemorrhagic telangiectasia. HSF Grant in Aid, 2002 – 2005

Letarte M (PI): A molecular diagnostic test for hereditary hemorrhagic telangiectasia. CIHR, 2004 – 2005

Lewis G: Canada Research Chair, 2006 – 2011

Lewis G: Career Investigator Award HSFC, 2003 – 2008

Lewis G (PI): Determining the mechanisms of hepatic and intestinal lipoprotein overproduction in insulin resistant states. CIHR Operating Grant, 2004 – 2007

Lewis G (PI): Regulation of HDL metabolism. HSFO Operating Funds, 2005 – 2008

Lewis G (PI): Mechanism of fatty acid-induced impairment of glucose-stimulated insulin secretion. CDA Operating Funds, 2005 – 2007

Lewis G (Co-Inv): Glucose toxicity: Prevention of diabetes complications and preservation of pancreatic beta cell function. CIHR New Emerging Team Grant, 2002 – 2007

Lewis G (PI): Mechanisms of insulin sensitization with vasopeptidase inhibitors. HSFO Operating Funds, 2003 – 2006

Leytin V (PI), Freedman J (Co-App): Platelet apoptosis in vitro and in the circulation. HSFC, 2003 – 2005

Li R-K (PI): Cell transplantation for cardiovascular disease. HSFO, 2001 – 2006

~ 32 ~ Li R-K (PI): Cell transplantation to improve heart function. Ontario Ministry of Energy, Science & Technology, 2001 – 2006

Li R-K (PI): Autologous tissue-engineered grafts for congenital heart surgery. CIHR, 2003 – 2008

Li R-K (PI): Vasculogenesis induced by cell transplantation. HSFO, 2003 – 2007

Li R-K (PI), Fedak PW: Gene-enhanced cell transplantation to reverse heart failure. HSFO, 2004 – 2007

Li R-K (PI), Fazel S: The interplay of recruited stem cells and the matrix after myocardial infarction: Shifting the balance toward repair. CIHR, 2004 – 2009

Lindsay TF: Ruptured abdominal aortic aneurysm: Molecular mechanisms to clinical studies. PSI, 2004 – 2006

Liu P: Biomarkers in cardiovascular disease. Genome Canada, 2004 – 2007

Liu P: Gene-environment factors in heart failure (CHFNET). CIHR, 2002 – 2007

Liu P: Cardiovascular health research advancements molecule to populations (TACTICS). CIHR, 2002 – 2008

Liu P: Host response patterns in heart failure (CHF-CORE). CIHR, 2003 – 2008

Liu P: Molecular mechanisms of viral myocarditis. CIHR, 2004 – 2009

Liu P: Cytokines in heart failure. CIHR, 2001 – 2006

Liu P: Oxidative stress & iron overload cardiomyopathy. CIHR, 2001 – 2006

Liu P: Chlamydia & atherosclerosis: Immune insights (Rated #1 by Panel). HSF, 2003 – 2008

Liu P: The role of aldosterone in cardiovascular remodeling. HSF, 2004 – 2007

~ 33 ~ Liu P: The role of inflammation in stem cell homing post cardiac injury. HSF, 2003 – 2006

Liu P: Cardiovascular complications in diabetes. CIHR New Frontiers Program, 2005

Liu P, 31 Co-Applicants including Wittnich C: Training program in cardiovascular research: Molecules to humans, heart failure to prevention (TACTICS). CIHR, 2002 – 2007

Liu P, Stewart DJ: T-cell based immune mechanisms of chlamydia vascular injury. HSFC, 2003 – 2008

Liu P (Director), Backx P, Husain M, MacLennan D, Parker T, Sole MJ, Stewart DJ (Members): Determinants of host susceptibilities of heart failure. CIHR Group Grant, 2003 – 2008

Liu P, Backx P, Husain M, MacLennan DH, Parker T, Sole MJ, Stewart DJ: Coordinated original research in elucidation of mechanisms in heart failure (CHF-CORE). CIHR, 2004 – 2009

Liu PP, Backx PH, Dhalla NS, Dixon IMC, Kirshenbaum LA, Tu JV (Co-Inv), et al: A training program in cardiovascular research: Molecules to populations, heart failure to prevention. CIHR, 2002 – 2008

Mazer CD (Co-I): A randomized trial of a lung-open ventilation strategy (LOVS) in acute lung injury. CIHR, 2000 – 2006

Mazer CD (Co-I): Blood conservation using antifibrinolytics: A randomized trial in a cardiac surgery population – The BART Study. CIHR, 2002 – 2005

McIlroy W, Brooks D: Early exercise intervention after stroke: Influence on functional capacity, sensorimotor recovery and risk of future strokes. CIHR Operating Grant, 2003 – 2006

McIllroy W (PI), Thomas SG, et al: Early exercise intervention after stroke: Influence on functional capacity, sensorimotor recovery, and risk of future strokes. CIHR, 2003 – 2005

Mentzer SJ (PI), Letarte M (Co-Ap): Physiology of systemic and pulmonary microangiectasias. NIH Operating Grant, 2003 – 2007

Nag S, Stewart DJ: Regulation of cerebrovascular homeostasis and repair by angiogenic factors. HSFO, 2004 – 2006

~ 34 ~ Ni H (PI), Freedman J (CoPI): Investigation of pathogenesis of immune thrombocytopenia and efficacy and mechanism of action of IVIG in a novel mouse model. CIHR/Canadian Blood Services Partnership Fund, 2003 – 2006

Ni H (PI), Freedman J (CoPI): Pathogenesis of fetal and neonatal alloimmune thrombocytopenia and mechanism of action of IVIG in a novel mouse model. CIHR, 2004 – 2007

Ni H (PI): Novel mechanisms of platelet aggregation: Roles of alternative ligands of b3 integrins in thrombosis and hemostasis. HSFO, 2005 – 2008

Ni H (PI), Freedman J (Co-PI): Study of fetal and neonatal alloimmune thrombocytopenia in a novel mouse model and investigation of efficacy and mechanism of action of IVIG in these disorders. Bayer/Canadian Blood Services/Hema-Quebec/CIHR Partnership Fund, 2004 – 2005

Ni H (PI): Freedman J (Co-PI): Novel mechanisms of platelet aggregation independent of von Willebrand factor and fibrinogen, and their effect on thrombosis and hemostasis. HSFO, 2003 – 2005

Nicholas B, Antle B, Beaune L, Coates A,… West LJ: Exploring the psychosocial and health service conse- quences of SARS on children and their families: Lessons learned for pediatric health care practice and policy. CIHR, 2004 – 2006

Nolan RP (PI), Ruckholm E, Stewart DE (Co-PI’s): Community outreach and heart health risk reduction trials (COHRT) component study 1: Efficacy of group outreach methodology. HSFO, 2002 – 2006

Pang CY, Forrest CR, Neligan PC: Global protection of skeletal muscle against ischemic necrosis and vascular dysfunction by non-invasive remote ischemic preconditioning: Efficacy and mechanism. CIHR Operating Grant, 2003 – 2006

Parker J (PI): Neurochemical effects of different pacing modalities in CHF. HSF, 2004- 2007

Parker J (PI): Studies concerning the vascular effects of the organic nitrates. HSF, 2004- 2007

Parker J (PI): Studies concerning the vascular effects of the organic nitrates. CIHR, 2004- 2007

Parker T (PI): Regulation of cardiac structure and function by the EF-hand proteins. CIHR Operating Grant, 2003 – 2006

Parker T (Co-Inv): Coordinated original research in elucidation of mechanisms in heart failure (CORE- CHF). CIHR Group Grant, 2003 – 2008

~ 35 ~ Parker T (PI): Inhibition of the cardiac hypertrophic phenotype by the calcium-binding protein, S100B. CIHR Operating Grant, 2002 – 2005

Parker T (PI): Role of S100B-dependent pathways in the cardiac response to disease. CIHR, 2005 – 2010

Pilote L, Cox JL, Ghali WA, Humphries KH, O’Louglin JL, Tu JV (Co-Inv), et al: Gender and sex determinants of cardiovascular disease: From bench to beyond. CIHR, 2004 – 2009

Pilote L, Abrahamowicz M, Eisenberg MJ, Humphries KH, Joseph L, Rahme E, Tu JV (Co-Inv): A population-based analysis of the effectiveness and determinants of use of cardiac drugs for congestive heart failure. CIHR, 2004 – 2007 Puri M (PI), Letarte M (Co-Ap): Role of endoglin in mammalian cardiovascular development. HSF Grant in Aid, 2004 – 2006

Rand ML: The procoagulant surface of activated platelets: Persistence in vivo and in vitro. HSFO, 2004 – 2007

Rao V: Transplant vasculopathy: The role of endothelium. Am Assoc Thorac Surgeons, Robert E. Gross Scholarship, 2003 – 2005

Rao V: Transplant vasculopathy: The role of endothelium. CIHR, 2003 – 2008

Romans SE (PI), Benazon LR, Einstein G, Kreindler D, Laredo SE, Morgan K, Stewart DE, Toner BB (Co- PI’s): Mood changes and daily life. CIHR, 2005 – 2008

Rowlands J, Wright GA, et al: Imaging Research Centre for Cardiac Intervention Canadian Foundation for Innovation, 2002 – 2006

Sefton M (PI), Gotlieb AI, Yeo E (Coll): Modular tissue engineering components for vascularized con- structs. NIH, 2002 – 2005

Simmons CA: Novel devices for high throughput mechanobiology. Connaught Foundation, 2005 – 2006

Singer P (PI), Cheung AM, Deber R… Stewart DE, Till J (Co-Ap’s): Canadian program on genomics and global health: International and comparative perspectives on health systems and insurance implications of new genetic testing. Genome Canada, 2001 – 2006

Slutsky AS, St. Michael’s Hospital: Critical Care Unit for Research Excellence (CCURE) [Group grant including approximately 20 critical care physicians/specialists from southern Ontario]. Canada Foundation for Innovation & Ontario Innovative Trust, 2002 – 2006

~ 36 ~ Slutsky AS: Biotrauma: Mechanisms of lung injury and distal organ dysfunction. CIHR, 2004 – 2009

Slutsky AS (PI), Dorian P (CoI), Morrison L: Clinical research consortium to improve resuscitation outcomes: From bench to bedside to curbside. NIH/CIHR/HSFC, 2004 – 2009

Sole M (PI): Molecular cardiology. G.H. Wood Foundation, 2000 – 2005

Sole M: Heart failure. CIHR Group Grant, 2001 – 2004

Sole M: Coordinated original research in elucidation of mechanisms of HR. CIHR Group Grant, 2003 – 2008

Sole M (PI): Circadian rhythms in the heart. HSFO, 2003 – 2006

Stewart DE (PI), Gucciardi E (CoPi): Psychosocial determinants of attrition in diabetes education service use and its impact on diabetes management outcomes. Can Diabetes Assoc, 2003 – 2005

Stewart DE (PI), Barata P: Housing discrimination against victims of domestic violence. Canada Mortgage and Housing Corp, 2004 – 2005.

Stewart DE, Robertson EK, Weller IMR (Co-PI’s): The relation between work related factors and mental health and well being in Canadian men and women. CIHR, 2003 – 2004

Stewart DE, Bercovitz K, Poland BD, et al: Reducing infant exposure to environmental tobacco smoke in private places: A qualitative study. Can Tobacco Control Res Initiative, 2001 – 2005

Stewart DJ: Mechanisms of angiogenesis: Biological and therapeutic potential of angiopoietins. CIHR, 2003- 2006

Stewart DJ, Courtman D: Microvascular endothelial cell loss in pulmonary hypertension. CIHR, 2002 – 2006

Stewart DJ (PI), Husain M (CoPI): Pathophysiological relevance of endothelin-1. CIHR Operating Grant, 2001 – 2004 2005 – 2010

Stewart DJ, Husain M: Targeted over-expression of inducible NO synthase: Relevance for the pathogenesis of cardiovascular disease. HSFO Operating Grant, 2002 – 2005 2005 – 2008

~ 37 ~ Stewart DJ, Husain M, Han R: NO-Synthase in cardiovascular health and disease. HSFO, 2005 – 2008

Stewart DJ, Courtman D: Microvascular endothelial cell loss in pulmonary arterial hypertension. CIHR, 2005 – 2010

Strauss B (PI): The role of adventitial angiogenesis in the arterial response to injury. CIHR. 2002 – 2005

Strauss B (PI): The role of perlecan in the pathophysiology of cardiovascular disease. CIHR, 2004 – 2007

Strauss B (Co-Inv): Role of matrix metalloproteinase in atrial remodeling in heart failure. CIHR, 2004 – 2007

Strauss B (PI), Wright GA, et al: Microvessel formation in chronic total occlusions: Pathophysiology and role in successful guide-wire crossing. CIHR, 2005 – 2008

Strauss SE, Goel V, David DA, Evans MF Laupacis A, Tu JV (Co-Inv): Randomized trial of an internet- based evidence-based medicine continuing education intervention. CIHR, 2002 – 2006

Tanswell AK, Belik J (CoPI), Chan A, O’Brodovich H, et al: Group in Lung Development. CIHR Group Grant, 2004 – 2009

Thomas SG, Franche R-L: Cardiac rehabilitation and readiness to return to work in patients with cardiovascular disease. Toronto Rehabilitation Institute, Toronto Cardiac Care Network, 2002 – 2004

Thomas SG, Brooks D: Predicting participation in cardiac rehabilitation after coronary artery bypass surgery. TRI Research Fund, 2002 – 2004

Thomas SG: Target detection and marksmanship under noise stress (TD&M). DRDC, 2003 – 2005

Tourangeau AE, Doran DM, McGillis Hall L, O’Brien-Pallas L, Pringle D, Tu JV (Co-Inv): Nursing and other determinants of hospital level outcomes such as 30-day mortality and readmission rates. CIHR, 2002 – 2005

Tourangeau AE, Tu JV (Co-Inv), Doran DM, Pringle D, et al: Nurse staffing work environments: Relationships with hospital-level outcomes. CIHR, 2002 – 2005

Trope GE (PI), Ethier R: In vivo testing and licensing of a glaucoma shunt valve: Phase II. PSI, 2005 – 2006

~ 38 ~ Tsushima RG (PI): Expression of TRP channels in the heart. Premier’s Research Excellence Award, 2001 – 2006

Tsushima RP (PI): Regulation of cardiac nonselective cation channels. HSFO, 2002 – 2005

Tsushima RG (PI), Gaisano HY (Co-PI): SNARE protein interactions with cardiac and vascular Kv channels. HSFO, 2004 – 2006

Tu JV, Ghali WA, Pilote L, Cox JL, Humphries KH, et al: Canadian cardiovascular outcomes research team II. CIHR, 2005 – 2006

Tu JV, Novick RJ, Anderson J, Geoffrey M, Feindel CM, et al: Understanding the link between quality of care and outcomes report cards for coronary artery bypass graft (CABG) surgery in Ontario. HSFO, 2004 – 2006

Tu JV (PI), Fremes SE, Naylor CD, Austin PC, Anderson GM, Feindel CM, Novick RJ: Understanding the link between quality of care and outcomes report cards for coronary artery bypass graft surgery in Ontario. HSFO, 2004 – 2006

Tu K, Hux JE, Mamdani M, Jaakimanian L, Manuel D, Tu JV (Co-Inv): Evaluation project of primary health care payment and delivery models on screening, detection and control of hypertension. Ministry of Health and Long-Term Care, 2004 – 2006

Tu JV (PI), Ghali WA, Cox JL, Knudtson M, Laupacis A, et al: Canadian cardiovascular outcomes research team. HSFC, 2001 – 2005

Tu JV (PI), Ghali WA, Cox JL, Knudtson M, Laupacis A, et al: Canadian cardiovascular outcomes research team. CIHR, 2001 – 2005

Tu JV (PI): Canada Research Chair in Health Services Research, Tier 2. CIHR, 2001 – 2006

Tu JV (PI), Chan B, Naylor CD: Quality of acute myocardial infarction care. MRC, 2000 – 2005

Verma S, Weisel RD (Co-PI): Modulating endothelial progenitor cells for myocardial regeneration: Role of PPARγ. HSFO, 2004 – 2006

Weintraub WS, Borger MA, Multiple Other Co-Investigators: Outcome Assessment of Mitral Valve Replacement and Repair NIH, 2003 – 2005

~ 39 ~ Weisel RD (PI), Verma S, Yau TM: Stem cells and restenosis: Defining the new paradigm. HSFO, 2003 – 2005

Weisel RD (PI), Verma S, Fazel S: Cardiac regeneration by cell transplantation. HSFO, 2004 – 2006

West LJ: Investigation of neonatally-induced allograft acceptance in a mouse model. PSI, 2003 – 2005

West LJ: Cardiac allograft tolerance induction during immaturity. HSFO, 2003 – 2007

West LJ: Investigation of neonatal tolerance induced by ABO-incompatible infant heart transplantation. CIHR, 2004 – 2007

West LJ: Investigation of neonatal immune tolerance induced by ABO-incompatible heart transplantation in a murine model. HSFO, 2004 – 2007

Wilson GJ (PI), Backx PH (Co-Inv): Ischemic preconditioning of the myocardium: Role of cell volume regulation. HSFO, 2002 – 2006

Wilson GJ (PI): Research on acellular matrix; tissue engineering approaches for pediatric cardiovascular reconstruction. CIHR

Wilson H (PI), Flanagan JG (Co-Ap): CIHR strategic training program in vision health research. NSERC, 2003 – 2009

Wittnich C: Oxygen stress in newborn hearts (renewal). HSFO, 2002 – 2006

Wittnich C: Impact of gender on myocardial pathology & ischemia/reperfusion (renewal). HSFO, 2004 – 2007

Wolfson C, Kirkland S, Raina P, Stewart DE (Co-Ap), et al: The Canadian Longitudinal Study of Aging: Developmental Activities – Phase I. CIHR, 2004 – 2006

Wright GA: Magnetic resonance imaging for ischemic heart disease. CIHR, Investigator Award, 2000 – 2006

Wright GA, Prato F: Ontario Consortium for Cardiac Imaging. Ontario Research and Development Challenge Fund, 2000 – 2006

~ 40 ~ Wright GA, Dick A, Merchant N: Magnetic resonance imaging for ischemic heart disease. CIHR, 2003 – 2007

Wright GA, Merchant N, Rubin BB: Magnetic resonance imaging for ischemia. CIHR, 2000 – 2005

Wright GA, Dick AJ: A 6-degree-of freedom device for 3D navigation in real-time. CIHR, 2004 – 2005

Zingg DW (PI), Ethier R (CoPI): Development and application of LES algorithms for simulation of tur- bulent flows. Connaught Foundation, 2002 – 2005

Zu JW, Li R-K (Co-Ap): Development of a new, portable biomedical device for in vivo measurement of regional heart tissue elasticity. NSERC, 2004 – 2007

Zwarenstein M, Cox J, Chan B, Abrahams C, Sherrard H, Tu JV (Co-Inv), Tepper J: Demand of cardiovascular care in Canada: Modules to use available human resources to best deliver care. CIHR, 2004 – 2007

~ 41 ~ PUBLICATIONS

Abdalla S, Cymerman U, Rushlow D, Chen N, Stoeber G, Lemire E, Letarte M: Novel mutations and polymorphisms in genes causing hereditary hemorrhagic telangiectasia. Hum Mutat, 2005;25:320-321.

Abdalla SA, Gallione CJ, Barst RJ, Horn EM, Knowles JA, Marchuk DA, Letarte M, Morse JH: Primary pulmonary hypertension in families with Hereditary Hemorrhapic Telangiectasia. Eur Respir J, 2004;23:373- 377.

Ahmad F, Shik A, Vanza R, Cheung AM, George U, Stewart DE: Voices of South Asian women: Immigration and mental health. Women Health, 2004;40:113-130.

Ahmad F, Shik A, Vanza R, Cheung AM, George U, Stewart DE: Popular health promotion strategies among Chinese and East Indian immigrant women. Women Health, 2004;40:21-40.

Ahmad F, Stewart DE: Predictors of clinical breast examination among South Asian immigrant women. J Immigr Health, 2004;6(3):119-126.

Al-Hesayen A, Azevedo ER, Floras JS, Hollingshead S, Lopaschuk GD, Parker JD: Selective versus nonselective beta-adrenoceptor blockade in heart failure: Differential effects on myocardial energy substrate utilization. Eur J Heart Fail, 2005;7:618-623.

Al-Kwifi O, Kim JK, Stainsby J, Huang Y, Sussman MS, Wright GA: Pulsatile motion effects on 3D magnetic resonance angiography: Implications for evaluating carotid artery stenoses. Magn Reson Med, 2004;52(3):605- 611.

Al-Omran M, Lindsay TF, Verma S, Weisel RD, Sternbach Y: Clinical decision making for endovascular repair of abdominal aortic aneurysm. Circulation, 2004;110:e517-e523.

Alter DA, Austin PC, Tu JV: Community factors, hospital characteristics and inter-regional outcome varia- tions following acute myocardial infarction in Canada. Can J Cardiol, 2005;21:247-255.

Al-Radi OO, Austin PC, Tu JV, David TE, Yau TM: Mitral repair versus replacement for ischemic mitral regurgitation. Ann Thorac Surg, 2005;79(4):12601267.

Armour A, Mainprize JG, Fialkov J, Forrest CR, Phillips JH, Antonyshyn O: Frontal Sinus Fracture Outcomes: A Ten Year Review. IN: Craniofacial Surgery 10: Proceedings of the Tenth International Congress of the International Society of Craniofacial Surgery. (Ed. Salyer KE), Medimond, San Lazzaro, Bologna Italy, 2004;309-312.

Armstrong PW, Bogaty P, Buller CE, Dorian P, O’Neill BJ: The 2004 ACC-AHA guidelines: A perspective and adaptation for Canada by the Canadian Cardiovascular Society Working Group. Can J Cardiol, 2004;20(11):1075-1079.

Austin PC, Tu JV, Daly PA, Alter DA: The use of the propensity score for estimating treatment effects: Administrative versus clinical data. Stat Med, 2005;24:791-816 (Epub Feb 2005).

~ 42 ~ Azami T, Preiss D, Somogyi R, Vesely A…Fisher JA: Calculation of O2 consumption during low-flow anesthesia from tidal gas concentrations, flowmeter, and minute ventilation. Biomed Eng and Computing, 2004;18:325-332.

Aziz A, Anderson GH, Giacca A, Cho F: Hyperglycemia after protein ingestion concurrent with injection of a GLP-1 receptor agonist in rats: A possible role for dietary peptides. Am J Physiol Regul Integr Comp Physiol, 2005 May, Epub ahead of print.

Bandali K, Belanger MP, Wittnich C: Can exposure to clinically relevant levels of hyperoxia cause OFR-mediated membrane injury, alter myocardial function and hemodynamics in the newborn? Am J Physiol Heart Circ Physiol, 2004;287:H553-H559.

Barata P, McNally MJ, Sales I, Stewart DE: Defining and responding to wife abuse: Using women’s words in prevention education. Womens Health Issues, 2005;15:134-144.

Beaune L, Forrest CR, Keith T: Adolescents’ perspective on living and growing up with Treacher Collins Syndrome: A qualitative study. Cleft Palate Craniofac J, 2004;41(4):343-350.

Beber B, Phillips JH, Forrest CR: Hydroxyapatite Cement Cranioplastyin the Pediatric Population. IN: Craniofacial Surgery 10: Proceedings of the Tenth International Congress of the International Society of Craniofacial Surgery. (Ed. Salyer KE), Medimond, San Lazzaro, Bologna Italy, 2004;227-230.

Beck CA, Richard H, Tu JV, Pilote L: Administrative data feedback for effective cardiac treatment. JAMA, 2005;294(3):309-317.

Belik J, Jankov RP, Pan J, Tanswell AK: A bronchial epithelium-derived factor reduces pulmonary vascular tone in the newborn rat. J Appl Physiol, 2004;96:1399-1405.

Belik J, Jankov RP, Pan J, Yi M, Chaudhry I, Tanswell AK: Chronic 02 exposure in the newborn rat results in decreased pulmonary arterial nitric oxide release and altered smooth muscle response to isoprostane. J Appl Physiol, 2004;96:725-730.

Belik J, Jankov RP, Tanswell AK: Peroxynitrite inhibits relaxation and induces pulmonary artery muscle con- traction in the newborn rat. Free Radic Biol Med, 2004;37:1384-1392.

Belik J, Pan J, Jankov RP, Tanswell AK: Bronchial epithelium-associated pulmonary arterial muscle relaxation in the rat is absent in the fetus and suppressed by postnatal hypoxia. Am J Physiol Lung Cell Mol Physiol, 2005;288(2):L384-L389.

Bogaty P, Buller CE, Dorian P, O’Neill BJ, Armstrong PW: Applying the new STEMI guidelines: 1. Reperfusion in acute ST-segment elevation myocardial infarction. CMAJ, 2004;171(9):1039-1041.

Borger MA, Preston M, Ivanov J, Fedak PWM, Davierwal P, Armstrong A, David TE: Should the ascending aorta be replaced more frequently in patients with bicuspid aortic valve disease? J Thorac Cardiovasc Surg, 2004;128:677-683.

~ 43 ~ Borger MA: Preventing stroke during coronary bypass: Are we focusing on the wrong culprit? J Card Surg, 2005;20:58-59.

Borger MA, David TE, Doll N, Mohr FW: Intraoperative fracture of the right coronary artery: Recognition and management. Ann Thorac Surg, 2005;79:693-696.

Brander L, Slutsky AS: Review: Year in review in Critical Care, 2003 and 2004: Respirology and critical care. Crit Care Med, 2005;9:1-6 (Epub July 2005).

Brooks D, Solway S, MacDermid J, Switzer-McIntyre S, Brosseau L, Graham ID: The quality of clinical practice guidelines in physical therapy. Physiother Can, 2005;57:123-134.

Brooks D, O’Brien K, Geddes L, Crowe J, Reid WD: Is inspiratory muscle training effective for individuals with cervical spinal cord injury? A qualitative systematic review. Clin Rehabil, 2005;19:237-246.

Brooks D, King A, Tonack M, Simson H, Gould M, Goldstein R: User perspectives on issues that influence the quality of daily life of ventilator-assisted individuals. Can Respir J, 2004;11:547-554.

Brooks D, Parsons J, Tran D, Jeng B, et al: The two-minute walk test as a measure of functional capacity I cardiac surgery patients. Arch Phys Med Rehabil, 2004;85:1525-1530.

Brooks D, Fancott CA, Falter L-B, McFarlane A, Nonoyama ML: The development of a helpline for chronic obstructive pulmonary disease (COPD). Patient Educ Couns, 2004;54:329-336.

Bucerius J, Gummert JF, Walther T, Borger MA, Doll N, Falk V, Mohr FW: Impact of off-pump coronary bypass grafting on the prevalence of adverse perioperative outcome in women undergoing coronary artery bypass grafting surgery. Ann Thorac Surg, 2005;79:807-812.

Bunda S, Kaviani N, Hinek A: Fluctuations of intracellular iron modulate elastin production. J Biol Chem, 2005;280:2341-2351.

Burt VK, Wohlreich MM, Mallinckrodt CH, Detke MJ, Watkin JG, Stewart DE: Duloxetine for the treatment of major depressive disorder in women aged 44-55 years. Psychosomatics, 2005;46(4).

Butany JW, Naseemuddin A, Nair V, Borger MA, Daniel L: Infective endocarditis in a Hancock bioprosthetic heart valve. J Card Surg, 2005;20:389-392.

Butany J, Mahendran R, Nair V, Lindsay T: Postimplantation changes in a composite pericardium-vein graft. Cardiovasc Pathol, 2004;13(4):237-239.

Butany J, Nair V, Ahluwalia MS, El Demellwy D, Siu S, Feindel C: Papillary fibroelastoma of the interatrial septum. J Card Surg, 2004;19(4):349-353.

Butany J, Nair V, Ahluwalia MS, Graba J, Demellawy DE, Rao V, Ross H: Hypersensitivity myocarditis complicating hypertrophic cardiomyopathy heart. Can J Cardiol, 2004;20(9):911-914.

~ 44 ~ Butany J, El Demellawy D, Collins MJ, Nair V, et al: Constrictive pericarditis: Case presentation and a review of the literature. Can J Cardiol, 2004;20(11):1137-1144.

Butany J, El Demellawy D, Collins MJ, Israel NSh, Graba J, David TE: A large left atrial myxoma. J Card Surg, 2004,19(6):547-551.

Butany J, Maseemuddin A, Nair V, Feindel CM: DeBakey Surgitool mechanical heart valve prosthesis, explanted at 32 years. Cardiovasc Pathol, 2004;128(12):1346-1350.

Butany J, Nair V, Ahluwalia M, Woo A, Graba J, David TE: Honeycomb-like healed abscess: An unusual complication of infective endocarditis. J Card Surg, 2005;20(1):81-84.

Butany J, El Demellawy D, Collins MJ, Nair V, Graba J, Taebong C, David TE: Ascending aortic aneurysm with dissection and aortic insufficiency. J Card Surg, 2005;20(1):85-89.

Butany J, Collins MJ: Analysis of prosthetic cardiac devices: A guide for the practicing pathologist. J Clin Pathol, 2005;58(2):113-124.

Butany J, Collins MJ, Duchnay M, El Demellawy D, Karski J, Ralph-Edwards AC: A quadricuspid aortic valve. J Card Surg, 2005;20(2):193-197.

Butany J, Nair V, Naseemuddin A, Nair GM, Catton C, Yau T: Cardiac tumors: Diagnosis and management. Lancet Oncol, 2005;6:219-228.

Butany J, Leong SW, Carmichael K, Komeda M: A 30-year analysis of cardiac neoplasms at autopsy. Can J Cardiol, 2005;21(8):675-680.

Cameron JI, Shin JL, Williams D, Stewart DE: A brief problem solving intervention for family caregiver to individuals with advanced cancer. J Psychosom Res, 2004;57(2):137-143.

Carpentier A, Patterson BW, Uffelman KD, Salit I, Lewis GF: Mechanism of highly active anti-retroviral therapy-induced hyperlipidemia in HIV infected individuals. Atherosclerosis, 2005;178:165-172.

Chamchad D, Karski J, Djaiani G, Butany J, Klein A, David TE: Chronic paravalvular abscess following aortic valve replacement. J Cardiothorac Vasc Anesth, 2004;18(6):820-822.

Chan NLM, Bourdeau S, Vera S…Letarte M: Umbilical vein and placental vessels from newborns with hereditary hemorrhagic telangiectasia type 1 genotype are normal despite reduced expression of endoglin. Placenta, 2004;25:208-217.

Cicutto L, Brooks D, Henderson K: Self care issues from the perspective of individuals with chronic obstructive pulmonary disease. Patient Educ Couns, 2004;55:168-176.

Clark AF, Brotchie D, Read AT, Hellberg P, English-Wright S, Pang IH, Ethier CR, Grierson I: Dexamethasone alters F-actin architecture and promotes cross-linked actin network formation in human trabecular meshwork tissue. Cell Motil Cytoskeleton, 2005;60:83-95.

~ 45 ~ Connelly PW, Maguire GF, Draganov DI: Separation and quantitative recovery of mouse serum aryles- terase and carboxylesterase activity by size-exclusion chromatography and ultracentrifugation. J Lipid Res, 2004;45:561-566.

Connelly PW, Draganov DI, Maguire GF: Paraoxonase-1 does not reduce oxidation of phospholipids by peroxynitrite. Free Radic Biol Med, 2005;38:164-174.

Copland IB, Kavanagh BP, Engelberts D, McKerlie C, Belik J, Post M: High tidal volume ventilation causes different inflammatory responses in neonatal versus adult lung. Am J Respir Crit Care Med, 2004;169:739- 748.

Cox JL, Ramer SA, Lee DS, Humphries K, Pilote L, Svenson L, Tu JV for the Canadian Cardiovascular Outcomes Research Team Investigators: Pharmacological treatment of congestive heart failure in Canada: A description of care in five provinces. Can J Cardiol, 2005;21:337-343.

Cui N, Kang Y, He Y, Leung YM…Tsushima RG, Gaisano HY: H3 domain of syntaxin 1A inhibits KATP channels by its actions on the sulfonylurea receptor 1 mucleotide-binding folds-1 and -2. J Biol Chem, 2004;17:279(51):53259-53265.

Cunningham K, Gotlieb AI: The role of shear stress in atherogenesis. Lab Invest, 2005;85:1-15.

Damignani R, Klar K, Forrest C: Positional plagiocephaly among infants: Identification, management and prevention. UofT Med J, 2004;81(3):202.

David TE, Feindel CM, Ivanov J, Armstrong S: Aortic root replacement in patients with previous heart surgery. J Card Surg, 2004;19(4):325-328.

Davies PF, Passerini AG, Simmons CA: The aortic valve: Turning over a new leaf(let) in endothelial phenotypic heterogeneity. Arterioscler Thromb Vasc Biol, 2004;24:1331-1333.

Delgado D, Miriuka SG, Cusimano RJ, Feindel CM, Rao V, Ross HJ: Use of basiliximab and cyclosporine in heart transplant patients with preoperative renal dysfunction. J Heart Lung Transplant, 2005;24:166-169.

Dennis CL, Stewart DE: Treatment of postpartum depression, part 1: A critical review of biological interventions. J Clin Psychiatry, 2004;65(9):1242-1251.

Deonarain R, Cerullo D, Fuse K, Liu PP, Fish EN: Protective role for interferon-beta in coxsackievirus B3 infection. Circulation, 2004;110:3540-3543.

DesMeules M, Kazanjian A, Maclean H, Payne J, Stewart DE, Vissandjee B: Women’s health surveillance report: Introduction. BMC Women’s Health, 2004;25(4):S1.

Dharmakumar R, Hong J, Brittain J, Plewes DB, Wright GA: Oxygen-sensitive contrasts in blood for studay- state free precession imaging. Magn Reson Med, 2005;53(3):574-583.

Dharmakumar R, Wright GA: Understanding steady-state free precession: A geometric perspective. Concepts in Magn Reson, 2005;26(a):1-10.

~ 46 ~ Diaz RJ, Zobel C, Cho HC, Batthish M, Hinek A, Backx PH, Wilson GJ: Selective inhibition of inward rectifier K+ channels (Kir2.1 or Kir2.2) abolishes protection by ischemic preconditioning in rabbit ventricular cardiomyocytes. Circ Res, 2004;95(3):325-332.

Djaiani G, Fedorko L, Borger MA, Mikulis D, et al: Mild to moderate disease of the thoracic aorta and new ischemic brain lesions after conventional coronary artery bypass graft surgery. Stroke, 2004;35:E356-E358.

Doenst T, Borger MA, David TE: Long-term results of bioprosthetic mitral valve replacement: The pericardial perspective. J Cardiovasc Surg, 2004;45:449-454.

Doenst T, Velazquez EJ, Beyersdorf F… Rao V for the STICH Investigators: To STICH or not to STICH – We know the answer, but do we understand the question? J Thorac Cardiovasc Surg, 2005;129:246-249.

Dorian P, Bogaty P, Buller CE, O’Neill BJ, Armstrong PW: Applying the new STEMI guidelines: 2. Disturbances of cardiac rhythm after ST-segment elevation myocardial infarction. CMAJ, 2005;171(9):1042- 1044.

Dorian P, Philippon F, Thibault B, Kimber S et al, for the ASTRID Investigators: Randomized controlled study of detection enhancements versus rate-only detection to prevent inappropriate therapy in a dual-chamber implantable cardioverter-defibrillator. Heart Rhythm, 2004;1(5):540-547.

Dorian P, Borggrefe M, Al-Khalidi HR, Hohnloser SM, et al: Placebo-controlled, randomized clinical trial of azimilide for prevention of ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator. Circulation, 2004;110:3646-3654.

Dorian P, Talajic M, Tang A: Implanted cardioverter defibrillators for the prevention of sudden death. Can J Cardiol, 2005;21(Suppl A):31-36.

Dos Santos CC, Han B, Andrade CF…Slutsky AS, Liu M: DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNF-(alpha), LPS and cyclic stretch. Physiol Genomics, 2004;19(3):331- 342.

Dos Santos CC, Zhang H, Liu M, Slutsky AS: Bench-to-bedside review: Biotrauma and modulation of the innate immune response. Crit Care, 2005;9(3):280-286.

Durbin A, Nadir N-A, Rosenthal A, Gotlieb AI: Nitric oxide promotes in vitro interstitial cell heart valve repair. Cardiovasc Pathol, 2005;15:12-18.

Emmett L, Husain M, Lee DS, Petrovici RL, et al: Reduced detection of triple vessel and left main coronary artery disease with attenuation corrected myocardial perfusion imaging. World J Nuc Med, 2005;3:41-48.

Esposito JG, Thomas SG, Kingdon L, Ezzat S: Growth hormone treatment improves arteriovenous oxygen difference during exercise in patients with human immunodeficiency virus-associated wasting: A randomized controlled trial. J Clin Endocrinol Metab, 2004;89(10):5124-5131.

Ethier CR, Read AT, Chan D: Biomechanics of Schlemm’s canal endothelial cells: Influence on F-actin architecture. Biophys J, 2004;87:2828-2837.

~ 47 ~ Faingold D, Hudson C, Flanagan JG, Guan K, et al: Assessment of retinal hemodynamics using the Canon laser blood flowmeter after a single dose of dorzolamide hydrochloride 2% eyedrops. Can J Ophthalmol, 2004;39:506-510.

Fan X, Ang A, Pollock-Barziv SM, Dipchand AI, Ruiz P, Wilson G: Donor-specific B-cell tolerance after ABO-incompatible infant heart transplantation. Nat Med, 2004;10(11):1227-1233 (Epub Oct 24).

Fann JI, Goar FG, Komtebedde J, Oz MC, Block PC, Foster E, Butany J, Feldman T, Burdon TA: Beating heart catheter-based edge-to-edge mitral valve procedure in a porcine model. Efficacy and healing response. Circulation, 2004;110(8):988-993.

Farcas GA, Poutanen SM, Mazzulli T, Willey BM, Butany J, et al: Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus. J Infect Dis, 2005;191(2):193-197.. Epub 2004 Dec 10.

Farkas LG, Eiben OG, Sivkov S, Tompson B, Katic MJ, Forrest CR: Anthropometric measurements of the ficial framework in adulthood: Age-related changes in eight age categories in 600 healthy white North American of European ancestry from 16 to 90 years of age. J Craniofac Surg, 2004;15(2):288-298.

Fazel S, Borger MA, Weisel RD, Cohen G, Pelletier MP, Rao V, Yau TM: Myocardial protection in reoperative coronary artery bypass grafting: Toward decreasing morbidity and mortality. J Card Surg, 2004;19:291-295.

Fazel S, Tang GHL, Angoulvant D, Cimini M, Weisel RD, Li R-K, Yau TM: Current status of cellular therapy for ischemic heart disease. Ann Thorac Surg, 2005;79:S2238-S2247.

Fazel S, Weisel RD, Verma S: A novel technique to assess flow-mediated vasodilation. Am J Cardiol, 2004;44:1478-1480.

Fazel S, Angoulvant D, Desai N, Yang S, Weisel RD, Li R-K: Cardiac restoration: Frontier or fantasy? Can J Cardiol, 2005;21:355-359.

Fedak PWM, David TE, Borger MA, Verma S, Butany J, Weisel RD: Bicuspid aortic valve disease: Recent insights in pathophysiology and treatment. Expert Rev Cardiovasc Ther, 2005;3:295-308.

Fedak PW, Rao V, Verma S, Ramzy D, Tumiati L,Miriuka S, Boylen P, Weisel RD, Feindel CM: Combined endothelial and myocardial protection by endothelin antagonism enhances transplant allograft preservation. J Thorac Cardiovasc Surg, 2005;129(2):407-415.

Fedak PWM, Smookler D…Mickle DAG, Watson KL…Weisel RD, Li R-K, Khokha R: TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation, 2004;110(16):2401-2409.

Fedak PWM, Verma S, Weisel RD, Li R-K: Cardiac Remodeling and failure: From molecules to man (Part I). Cardiovasc Pathol, 2005;14:1-11.

Fedak PWM, Verma S, Weisel RD, Li R-K: Cardiac Remodeling and failure: From molecules to man (Part II). Cardiovasc Pathol, 2005;14:45-60.

~ 48 ~ Fedak PWM, Weisel RD, Li R-K: Cell Transplantation for Cardiovascular Disease. IN: Surgery of the Chest, 7th Edition. (Eds. Sellke F, del Nido P, Swanson SJ). Elsevier Science Inc, New York, 2004;1711-1722.

Feindel CM, David TE: Aortic valve sparing operations: Basic concepts. Int J Cardiol, 2004;97(Suppl 1):61-66.

Ferguson ND, Chicke JD, Kacmare RM…Slutsky AS, Stewart TE: Combining high-frequency oscillatory ventilation and recruitment maneuvers in adults with early acute respiratory distress syndrome: The treatment with oscillation and an open lung strategy (TOOLS) trial pilot study. Crit Care Med, 2005;33(3):479-486.

Forrest CR: What’s new in plastic and maxillofacial surgery. Am C Surg J, 2005;200(3):399-408.

Forrest CR, Dirks P, Humphreys RP, Drake J, Rutka JT: Complications Following the Surgical Management of Non-Syndromic Unicoronal Synostosis in Infancy. IN: Craniofacial Surgery 10: Proceedings of the Tenth International Congress of the International Society of Craniofacial Surgery. (Ed. Salyer KE), Medimond, San Lazzaro, Bologna Italy, 2004;199-202.

Gabor YJ, Newman DM, Barnard-Roberts V, Korley V, Mangat I, Dorian P, Hanly PJ: Improvement in Cheyne-Stokes respiration following cardiac resynchronization theapy. Eur Respir J, 2005;26:95-100.

Gilmore E, Hudson C, Preiss D, Fisher JA: Retinal arteriolar diameter, blood velocity and blood flow response to an isocapnic hypoxic provocation. Am J Physiol Heart Circ Physiol, 2005;288(6):H2912-H2917.

Gilmore E, Hudson C, Venkataraman S, Preiss D, Fisher JA: Comparison of different hyperoxic paradigms to induce vasoconstriction – Implications for the investigation of retinal vascular reactivity. Invest Opthalmol Vis Sci, 2004;45(9):3207-3212.

Global IDEA Scientific Advisory Committee (Slutsky AS, Chair): Health and economic benefits of an accel- erated program of research to combat global infectious diseases. CMAJ, 2004;171(10):1203-1208.

Gori T, Harvey P, Floras JS, Parker JD: Continuous therapy with nitroglycerin impairs endothelium- dependent dilation but does not cause tolerance in conductance arteries: A human in vivo study. J Cardiovasc Pharmacol, 2004;44:601-606.

Grace SL, Evindar A, Brooks D, Jaglal S, Abramson B, Nolan RP: Increasing patient-initiation of cardiac rehabilitation referral in female percutaneous coronary intervention patients. Can J Cardiovasc Nurs, 2005;15:23-27.

Grace SL, Abbey SE, Shnek Z, Irvine J, Stewart DE: Prospective examination of anxiety persistence and its relationship to cardiac symptoms and recurrent cardiac events. Psychother Psychosom, 2004;73:344-352.

Grace SL, Hershenfield K, Robertson E, Stewart DE: Factors affecting perceived risk of contracting SARS among academic physicians. Infect Control Hosp Epidemiol, 2004;25(12):1111-1113.

Grace SL, Evindar A, Abramson BL, Stewart DE: Physician management preferences for cardiac patients: Factors affecting referral to cardiac rehabilitation. Can J Cardiol, 2004;20(11):1101-1107.

~ 49 ~ Grace SL, Fry R, Cheung A, Stewart DE: Cardiovascular Disease. BMC Women’s Health, 2004;25(4):Supple 1-S15.

Grace SL, Evindar A, Kung T, Scholey P, Stewart DE: Automatic referral to cardiac rehabilitation. Med Care, 2004;42(7):661-669.

Guan K, Hudson C, Flanagan JG: A cross-sectional comparison of the Heidelberg Retina Tomograph II and the Retinal Thickness Analyzer in the assessment of diabetic macular edema: Agreement with clinical assessment. Invest Ophthalmol Vis Sci, 2004;45:610-616.

Gucciardi E, Celasun N, Ahmad F, Stewart DE: Eating disorders. BMC Women’s Health, 2004;25(4):Suppl 1-S21.

Gullane PG, Lindsay TF: Carotid Body Tumors. IN: Operative Techniques in General Surgery. (Ed. Shaha AR). Elsevier, New York, 2004:125.

Harkin DW, Rubin B, Lindsay TF: Selective induced nitric oxide inhibition attenuates neutrophil mediated acute lung injury in a model of ruptured abdominal aortic aneurysm. Am Assoc Vasc Surg, 2004;1201S:230- 241.

Harvey PJ, Morris BL, Kubo T, Picton P, Su W, Notarius CF, Floras JS: Hemodynamic after-effects of acute dynamic exercise in sedentary normotensive postmenopausal women. J Hypertens, 2005;23:285-297.

Harvey PJ, Picton PE, Su WS, Morris BL, Notarius CF, Floras JS: Exercise as an alternative to oral estrogen for amelioration of endothelial dysfunction in postmenopausal women. Am Heart J, 2005;149:291-297.

Harvey PJ, Morris BL, Miller JA, Floras JS: Estradial induces discordant angiotensin and blood pressure responses to orthostasis in healthy postmenopausal women. Hypertension, 2005;45:399-405.

Hinek A, Titell M, Schoyer L, et al: Myocardial storage of chondroitin sulfate-containing moieties in Costello Syndrome patients with severe hypertrophic cardiomyopathy. Am J Med Genet, 2005;133A:1-12.

Hohnloser SH, Kuck KH, Dorian P, Roberts RS, et al: Prophylactic use of an implantable cardioverter-defibrillator after acute myocardial infarction. N Engl J Med, 2004;351-2481-2488.

Huang Y, Merchant N, Wright GA: Comparison of match-filtered 2D projection and elliptical centric- ordered 3D contrast-enhanced MR angiography. J Magn Reson Imaging, 2004;20(3):435-442.

Huang YC, Simmons CA, Kaigler D, Rice KG, Mooney DJ: Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4). Gene Ther, 2005;12:418-426.

Hudson C, Flanagan JG, Turner GS, Chen HC, Rawji MH, McLeod D: Exaggerated relative nasal-temporal asymmetry of macular capiliary blood flow in patients with clinically significant diabetic macular edema. Br J Ophthalmol, 2005;89:142-146.

~ 50 ~ Humphries KH, Kerr CR, Steinbuch M, Dorian P, for the Canadian Registry of Atrial Fibrillation (CARAF) Investigators: Limitations to antiarrhythmic drug use in patients with atrial fibrillation. CMAJ, 2004;171:741- 745.

Hwang DM, Chamberlain DW, Poutanen SM, Low DE, Asa SL, Butany J: Pulmonary pathology of severe acute respiratory syndrome in Toronto. Med Pathol, 2004.

Imai Y, Slutsky AS: High-frequency oscillatory ventilation and ventilator-induced lung injury. Crit Care Med, 2005;33(3):S129-S134.

Jackevicius CA, Alter D, Cox J, Daly P, Goodman S, Filate W, Newman A, Tu JV: Acute treatment of myocardial infarction in Canada 1999-2002. Can J Cardiol, 2005;21:145-152.

Jackson Z, Dajnowiec D, Gotlieb AI, Langille BL: Partial off-loading of longitudinal tension induces arterial tortusity. Arterioscler Thromb Vasc Biol, 2005;25.

Jackson ZS, Gotlieb AI, Langille BL: Arterial remodeling in response to decreased longitudinal tension. Arterioscler Thromb Vasc Biol, 2005;25:957-962.

Jenkins DJ, Kendall CWC, Marchie A…Connelly PW: Direct comparison of a dietary portfolio of cholesterol lowering foods with a statin in hypercholesterolemic participants. Am J Clin Nutr, 2005;81:380-387.

Jenkins DJA, Kendall CWC, Hamidi M, Vidgen E…Connelly PW, Onderdonk A, Rao AV: Effect of anti- biotics as cholesterol-lowering agents. Metabolism, 2005;54:103-112.

Johnson SR, Harvey PJ, Floras JS, et al: Impaired brachial artery endothelium dependent flow mediated dilation I systemic lupus erythematosus: Preliminary observations. Lupus, 2004;13:590-593.

Jones PJ, Raeini-Sarjaz M, Jenkins DJA…Connelly PW: Effects of a diet high in plant sterols, vegetable proteins, and viscous fibers on circulating sterol levels and red cell fragility in hypercholesterolemic subjects. Lipids, 2005;40:169-174.

Joshi AK, Leask RL, Myers JG, Ojha M, Butany J, Ethier CR: Intimal thickness is not associated with wall shear stress patterns in the human right coronary artery. Arterioscler Thromb Vasc Biol, 2004;24(12):2408- 2413. Epub 2004 Dec.

Kang Y, Leung YM, Manning-Fax JE, Xia F, Xie H, Sheu L, Tsushima RG, Light PE, Gaisano HY: Syntaxin- 1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A. J Biol Chem, 2004;279(45):47125-47131.

Karabegovic A, Shinawi M, Cymerman U, Letarte M: No live individual homozygous for a novel endoglin mutation was found in a consanguineous Arab family with hereditary hemorrhagic telangiectasia. J Med Genet, 2004;41:e119.

Karbouti K, Bettie WS, Wijeysundera DN, Chang C, Rao V, et al: Hemodilution during cardiopulmonary bypass in an independent risk factor for acute renal failure in adult cardiac surgery. J Thorac Cardiovasc Surg, 2005;129(2):391-400.

~ 51 ~ Kassam S, Cantor WJ, Patel D, Gilchrist IC…Strauss BH: Radial vs. femoral access for rescue percutaneous coronary intervention with adjuvant glycoprotein IIb/IIIa inhibitor use. Can J Cardiol, 2004;20(14):1439- 1442.

Kerr CR, Humphries KH, Talajic M…Dorian P, Newman D: Progression to chronic atrial fibrillation after the initial diagnosis of paroxysmal atrial fibrillation: Results from the Canadian Registry of Atrial Fibrillation (CARAF). Am Heart J, 2005;149:489-496.

Khan A, Ashrafpour H, Huang N…Forrest CR, Pang CY: Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: Efficacy and mechanism. Am J Physiol Regul Integr Comp Physiol, 2004;287(5):R1219-R1229.

Khan NA, McAlister FA, Lewanczuk RZ, Ogilvie RI: The 2005 Canadian Hypertension Education Program recommendations for the management of hypertension: Part II-Therapy. Can J Cardiol, 2005;21:657-672.

Ko DT, Austin PC, Chan BTB, Tu JV: Quality of care of international and Canadian medical graduates in acute myocardial infarction. Arch Intern Med, 2005;165:458-463.

Konen E, Merchant N, Gutierrez C, Provost Y, Mickleborough L, Paul NS, Butany J: True versus false left ventricular aneurysm: Differentiation with MR imaging-initial experience. Radiology, 2005;236(1):65-75. Epub 2005 Jun.

Konstantinov IE, Arab S, Kharbanda RK…Liu PP, Cukerman E, Coles JG, Redington AN: The remote ischemic preconditioning stimulus modifies inflammatory gene expression in humans. Physiol Genomics, 2005;19:143-150.

Kornecki A, Tsuchida S, Ondiveeran HK… Belik J, et al: Lung development and susceptibility to ventilator- induced lung injury. Am J Respir Crit Care Med, 2005;171(7):743-752.

Kuang D, Yao Y, Lam J, Tsushima RG, Hampson DR: Cloning and characterization of a family C orphan G-protein coupled receptor. J Neurochem, 2005;93(2):383-391.

Kuiper JW, Groeneveld AB, Slutsky AS, Plotz FB: Mechanical ventilation and acute renal failure. Crit Care Med, 2005;33(6):1408-1415.

La Scala GC, O’Donovan DA, Yeung I…Forrest CR: Radiation-induced craniofacial bone growth inhibition: Efficacy of cytoprotection following a fractionated dose regimen. Plast Reconstr Surg, 2005;115(7):1973-1985.

Lamarche B, Desroches S, Jenkins DJ… Leiter LA, Connelly PW: Combined effects of a dietary portfolio of plant sterols, vegetable protein, viscous fibre and almonds on LDL particle size. Br J Nutr, 2004;92:657-663.

Lambie L, Mattke S, OECD Cardiac Care Panel…Tu JV: Organisation de Cooperation et de Developpement Economiques (OECD). OECD Health Technical Paper 14: Selecting indicators for the quality of cardiac care at the health systems level in OECD countries, Paris, France, 2004.

Langille BL, Dajnowiec D: Cross-linking vasomotor and vascular remodeling: A novel function for tissue transglutaminase. Circ Res, 2005;96:9-11.

~ 52 ~ Langille BL, Dajnowiec D, Gotlieb AI: The Role of Rheology in Atherothrombotic Coronary Disease. IN: Atherothrombosis and Coronary Artery Disease, 2nd Edition. (Eds. Fuster V, Topol E, Nabel E). 2004:561- 568.

Lapointe N, Parker TG, Tsoporis JN, et al: Effects of the vasopeptidase inhibitor omapatrilat on peri- and postmyocardial infarction in Zucker lean rats. Can J Cardiol, 2005;21(3):291-297.

Lavery JV, Van Laethem MLP, Slutsky AS: Monitoring and oversight in critical care research (commentary). Crit Care, 2004;8:403-405.

Leask RL, Butany J, Johnston KW, Ethier CR, Ojha M: Human saphenous vein coronary artery bypass graft morphology, geometry and hemodynamics. Ann Biomed Eng, 2005,33(3):301-309.

Lee DS, Donovan L, Austin PC, Gong Y, Liu PP, Rouleau JL, Tu JV: Comparison of coding of heart failure and comorbidities in administrative and clinical data for use in outcomes research. Med Care, 2004;148:1041- 1046.

Lee DS, Mamdani MM, Austin PC, Gong Y, Liu PP, Rouleau JL, Tu JV: Trends in heart failure outcomes and pharmacotherapy: 1992 to 2000. Am J Med, 2005;116:581-589.

Lee J, Gotlieb AI: Microtubules regulate aortic endothelial cell actin microfilament reorganization in intact and repairing monolayers. Histol Histopathol, 2005;20:455-465.

Lee TC, Hanlon JG, Ben-David J, Booth GL, Cantor WJ, Connelly PW, Hwang SW: Risk factors for cardiovascular disease in homeless men. Circulation, 2005;111:2629-2635.

Letarte M, Voulgaraki D, Hartherley D, Foster-Cuevas M, Saunders NJ, Barclay N: Analysis of leukocyte membrane protein interactions using protein microarrays. BMC Biochem, 2005;6:2.

Leung N, Sakaue T, Uffelman K, Giacca A, Lewis GF: Prolonged elevation of plasma FFA completely abolishes the stimulatory effect of 24hrs moderate hyperglycemia on insulin sensitivity and b-cell function in obese men. Diabetologia, 2004;47:204-213.

Leung YM, Kang Y, Xia F, Sheu L, Gao X, Xie H, Tsushima RG, Gaisano HY: Open form of syntaxin-1A is a more potent inhibitor than wild-type syntaxin-1A of Kv2.1 channels. Biochem J, 2005;387(Pt 1):195-202.

Levy MM, Baylor MS, Bernard GR…Slutsky AS, Stewart TE, et al: Clinical issues and research in respiratory failure from severe acute respiratory syndrome. Am J Respir Crit Care Med, 2005;171:518-526.

Lewis GF, Murdoch S, Uffelman K… Adeli K, Brunzell JD: Hepatic lipase mRNE, protein and plasma enzyme activity is increased in the insulin-resistant fructose-fed Syrian Golden hamster and is partially normal- ized by the insulin sensitizer, rosiglitazone. Diabetes, 2004;53:2893-2900.

Lewis GF, Naples M, Uffelman K, Leung N, Szeto L, Watanabe T, Adeli A: Intestinal lipoprotein production is stimulated by acute elevation of plasma free fatty acids: Studies in insulin resistant and insulin sensitized Syrian Golden hamsters. Endocrinology, 2004;145(11):5006-5012, Epub 2004 Jul 12.

~ 53 ~ Lewis GF, Uffelman K, Naples M, Szeto L, Haidari M, Adeli K: Intestinal lipoprotein overproduction, a newly recognized component of insulin resistance, is ameliorated by the insulin sensitizer, rosiglitazone: Studies in the fructose-fed Syrian Golden hamster. Endocinology, 2005;146(1):247-255, Epub 2004 Oct 14.

Lewis GF: Lipid metabolism, bimonthly update. Curr Opin Lipidol, 2004;15(1):85-87 (Editoria/review).

Lewis GF, Rader D: New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res, 2005;96:1221-1232 (Invested review).

Leytin V, Allen D, Gwozdz A, Garvey B, Freedman J: Role of platelet surface glycoprotein Iba and P-selectin in the clearance of transfused platelet concentrates. Transfusion, 2004;44:1487-1495.

Lin Y, Berg AH, Iyengar P, Lam TKT, Giacca A, et al: The hyperglycemia-induced inflammatory response in adipocytes: The role of reactive oxygen species. J Biol Chem, 2005;280:4617-4626.

Lindsay MP, Kapral MK, Gladstone D, Holloway R, Tu JV, Laupacis A, Grimshaw JM: The Canadian Stroke Quality of Care Study: Establishing indicators for optimal acute stroke care. CMAJ, 2005;172:363-365.

Lindsay TF, Al’Omran M: Should all patients with Peripheral Arterial Disease be treated with an angiotensin converting enzyme inhibitor? Can J Cardiol, 2005;21(2):189-193.

Lindsay TF: Canadian Society for Vascular Surgery statement on endovascular aneurysm repair. CMAJ, 2005;172(7):867-868.

Lindsay TF: Ruptured Abdominal Aortic Aneurysms. IN: Atlas of Vascular Surgery. (Ed. Rutherford – 6th Edition). 2005, Chapter 102.

Liu PP, Fuse K, Chang G, Liu Y, Opavsky A: Viral myocarditis: Recent insights into the role of acquired and innate immunity responses. (Eds. Schultheiss HP, Poller W) Springer Verlag, 2004 (Review article).

Liu PP, Konstam M, Force T: Progress and highlights of the 7th Heart Failure Society of America meeting. J Am Coll Cardiol, 2004;43:1103-1109.

Liu T-B, Fedak PWM, Yasuda T, Kiani CG, Mickle DAG, Weisel RD, Jia Z-Q, Li R-K: Enhanced IGF- 1 expression improves smooth muscle cell engraftment after cell transplantation. Am J Physiol Heart Circ Physiol, 2004;287(6):H2840-H2849.

MacDermid JC, Brooks D, Solway S, Switzer-McIntyre S, Brosseau L, Graham ID: Reliability and validity of the AGREE instrument in assessment of clinical practice guidelines within physical therapy. BMC Health Services Res, 2005;5:18.

Macgowan CK, Al-Kwifi O, Varohayan F, Yoo S-J, Wright GA, Kellenberger CJ: Optimization of 3D contrast-enhanced pulmonary MR angiography in pediatric patients with cardiovascular disease. Magn Reson Med, 2005;54(1):207-212.

Mann DL, McMurray JJ, Packer M…Liu PP, et al: Targeted anticytokine therapy in patients with chronic heart failure: Results of the randomized etanercept worldwide evaluation (RENEWAL). Circulation, 2004;109:1594-15602. ~ 54 ~ Marcus JR, Rechner BP, Dirks…Forrest CR: Comparison of Early Extended Strip Craniectomy (ESC) Versus Total Cranial Vault Reshaping (TCV) in Sagittal Synostosis: CT and Clinical Assessment. IN: Craniofacial Surgery 10: Proceedings of the Tenth International Congress of the International Society of Craniofacial Surgery. (Ed. Salyer KE), Medimond, San Lazzaro, Bologna Italy, 2004;192-194.

Martinez FE, Lewis J, Copland IB, Egelberts D, Kavanagh BP, Post M, Belik J: High tidal volume increases surfactant release and lung compliance in the newborn rat. Ped Res, 2004;56:19-25.

Martino T, Arab S, Straume M…Liu PP, Trivieri M, Ralph M, Sole MJ: Day/night rhythms in gene expression of the normal murine heart. J Mol Med, 2004;82:256-264.

Mazzulli T, Kain K, Butany J: Severe acute respiratory syndrome: Overview with an emphasis on the Toronto experience. Arch Pathol Lab Med, 2004;128(12):1346-1350.

Mizuno T, Mickle DAG, Kiani CG, Li R-K: Overexpression of elastin in infarcted myocardium prevents scar expansion and heart dysfunction. Am J Physiol, 2005;288(6):H2819-2827.

Morrison LJ, Dorian P, Long J, Vermeulen M, et al: Out-of-hospital cardiac arrest rectilinear biphasic to monophasic damped sine defibrillation waveforms with advanced life support intervention trial (ORBIT). Resuscitation, Epub 2005 June.

Moses MA, Addison PD, Neligan PC…Forrest CR, Grover GJ, Pang CY: Mitochondrial KATP channels in hind limb remote ischemic preconditioning of skeletal muscle against infarction. Am J Physiol Heart Circ Physiol, 2004.

Munce SE, Robertson EK, Sansom SN, Stewart DE: Who is portrayed in psychotropic drug advertisements? J Nerv Ment Dis, 2004;192(4):284-288.

Murphy WL, Hsiong S, Richardson TP, Simmons CA, Mooney DJ: Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials, 2005;26:303-310.

Nanthakumar K, Newman D, Paquette M, Dorian P: A systematic evaluation of the determinants of defibrillation efficacy. Heart Rhythm, 2005;2:36-41.

Nian M, Lee P, Liu P: Inflammation, cytokines and post-myocardial infarction remodeling. Circ Res, 2004;94:1543-1553.

Nield L, Macgowan C, Valsangiacomo E, Wright GA, Hornberger L, Qi X, Yoo SJ: In vivo MRI measurement of blood oxygen saturation in children with congenital heart disease. Ped Radiol, 2005;35(2):179-185.

Ng DS, Maguire GF, Xie C, Lam E, Ugwu F, Connelly PW: Hypertriglyceridemia in lecithin-cholesterol acyltransferase deficient mice is associated with hepatic overproduction of triglycerides, increased lipogenesis and improved glucose tolerance. J Biol Chem, 2004;279:7636-7642.

Nolan RP, Kamath MV, Floras JS, Stanley J, Pang C, Picton P, Young Q: Heart rate variability biofeedback as a behavioural neurocardiac intervention to enhance vagal heart rate control. Am Heart J, 2005;149:1137. e1-1137.e7.

~ 55 ~ Oh J, Cha S, Aiken AH…Wright GA, Dillon WP, Nelson SJ: Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumours and regions of peritumoral edema. J Magn Reson Imaging, 2005;21:701-708.

Ohta K, Nakajima T, Cheah AY…Liu P, Husain M, Rabinovitch M: Elafin over-expressing mice have improved cardiac function after myocardial infarction. Am J Physiol Heart Circ Physiol, 2004;287(1):H286- H292.

Oudit GY, Trivieri MG, Khaper N, Husain T, Wilson GJ, Liu P, Sole MJ, Backx PH: Taurine supplementation reduces oxidative stress and improves cardiovascular function in an iron-overload murine model. Circulation, 2004;109:1877-1885.

Pagura SMC, Thomas SG, Woodhouse LJ, Ezzat S, Marks P: Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry differ in women awaiting total knee arthroplasty when compared to men. J Orthop Res, 2005;23(2):397-405.

Parkash R, Green MS, Kerr CR, Connolly SJ, Klein GJ, Sheldon R, Talajic M, Dorian P, Humphries KH: The association of left atrial size and occurrence of atrial fibrillation: A prospective cohort study from the Canadian Registry of Atrial Fibrillation (CARAF). Am Heart J, 2004;148:649-654.

Parkash R, Tang A, Wells G, Blackburn J, Stiell I, Simpson C, Dorian P, et al: Use of implantable cardioverter defibrillators after out-of-hospital cardiac arrest: A prospective follow-up study. CMAJ, 2004;171(9):1053- 1056.

Pattinson KTS, Somogyi RB, Fisher JA, Bradwell AR, and the Birmingham Medical Research Expeditionary Society: Efficient breathing circuit for use at altitude. J Wilderness Environ Med, 2005;16(2):101-103.

Pece-Barbara N, Vera S, Kathirkamathamby K…Letarte M: Endoglin null endothelial cells proliferate faster and are more responsive to TGF-b1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem, 2005;10.1074/jbc.M503471200.

Peerschke EIB, Minta J, Zhou SZ, McCaffrey TA, Gotlieb AI, Ghebrehiwet B: Expression of gClq-R/p33 and gClq-R/p33 ligands in human atherosclerotic lesions. Mol Immunol, 2004;41:759-766.

Peraud A, Drake JM, Armstrong D, Hedden D, Babyn P, Wilson G: Fatal ethibloc embolization of vertebro- basilar system following percutaneous injection into aneurismal bone cyst of the second cervical vertebra. Am J Neurosoradiol, 2004;25(6):1116-1120.

Perez-Gomez E, Eleno N…Letarte M, Bernabeu C, Quintanilla M: Characterization of murine S-endoglin isoform and its effect on tumor development. Oncogene, 2005;24:4450-4461.

Pollex R, Khan HMR, Connelly PW, Young TK, Hegele RA: The metabolic syndrome in Inuit. Diabetes Care (letter), 2004;27:1517-1518.

Pourdjabbar A, Parker TG, Nguyen KT, Desjardins JF, et al: Effects of pre, peri and postmyocardial infarction treatment with Losartan in rats: Effect of dose on survival, ventricular arrhythmias, function and remodeling. Am J Physiol, 2005;288(4):H1997.

~ 56 ~ Prasongsukarn K, Borger MA: Reducing cerebral emboli during cardiopulmonary bypass. Semin Cardiothorac Vasc Anesth, 2005;9:153-158.

Pratt CM, Dorian P, Al-Khalidi HR, Brum JM, et al: Design of the Shock Inhibition Evaluation with Azimilide (SHIELD) study: A novel method to assess antiarrhythmic drug effect in patients with an implantable cardioverter-defibrillator. Am J Cardiol, 2005;95:274-276.

Privitera S, Butany J, Silversides C, Leask RL, David TE: Artificial chordae tendinae: Long-term changes. J Card Surg, 2005;20(1):90-92.

Qiang B, Segev A, Beliard, Nili N, Strauss BH, Sefton MV: Poly(methylidene malonate 2.1.2) nanopar- ticles: A biocompatible polymer that enhances periadventitial adenoviral gene delivery. J Control Release, 2004;98(3):447-455.

Quaid PT, Flanagan JG: Defining limits of flicker defined form: Effect of stimulus size, eccentricity and number of random dots. Vision Res, 2005;45(8):1075-1084.

Quaid PT, Simpson TL, Flanagan JG: Frequency doubling illusion: Detection vs. form resolution optom. Vision Sci, 2005;82(1):36-42.

Quaid PT, Simpson T, Flanagan JG: Monocular and dichoptic masking effects on the frequency doubling illusion. Vision Res, 2004;44(7):661-667.

Qui W, Kohen-Avramoglu R…Lewis GF, Trinh D, Ukrade R, Adeli K: Overexpression of endoplasmic reticulum (ER)-60 protein downregulates apo B100 secretion and induces its intracellular degradation via a non-proteosomal pathway: Evidence for an ER-60-mediated and pCMB-sensitive intracellular degradative pathway. Biochemistry, 2004;43:4819-4831.

Qui W, Avramoglu RK, Dube N…Lewis GF, Cohn JS, Tremblay ML, Adeli K: Hepatic PTP-1B expression regulates the assembly and secretion of apolipoprotein B-containing lipoproteins: Evidence from protein tyro- sine phosphatase-1B overexpression, knockout and RNAi studies. Diabetes, 2004;53:3057-3066.

Ramzy D, Rao V: Myocardial Protection. (Eds. Salerno & Ricci). Ann Thorac Surg, 2005;79:1100 (Invited review).

Ramzy D, Rao V, Tumiati LC, et al: Tetrahydrobiopterin prevents cyclosporine induced vasomotor dysfunction. Transplantation, 2005;79(8):876-881.

Ramzy D, Rao V: Heart Transplantation. (Eds. Kirklin, Young, McGiffin). J Card Surg, 2004;19:186 (Invited book review).

Rao V: Charting the future by examining the past: Experience with implantable ventricular assist devices. Commentary on Pasque et al: Operative strategies to reduce complications after Novacor Left Ventricular Assist Device Insertion. J Card Surg, 2004;19:336-337.

Rasid S, Lewis GF: The mechanism of differential glucocorticoid and mineralocorticoid action in the brain and peripheral tissues. Clin Biochem, 2005;38:401-409.

~ 57 ~ Reheman A, Gross P, Yang H, Rui M, Allen D, Leytin V, Freedman J, Ni H: Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost, 2005;3:875-883.

Reid WD, Geddes EL, Brooks D, O’Brien K, Crowe J: Inspiratory muscle training in COPD. Physiother Can, 2004;56:128-142.

Retnakaran R, Hanley AJG, Raif N, Connelly PW, Sermer M, Zinman B: Reduced adiponectin concentration in women with gestational diabetes: A potential factor in progression to Type 2 diabetes. Diabetes Care, 2004;27:799-800

Retnakaran R, Hanley AJ, Raif N, Connelly PW, Sermer M, Zinman B: Hypodiponectinaemia in South Asian women during pregnancy: Evidence of ethnic variation in adiponectin concentration. Diabetes Med, 2004;21:388-392.

Retnakaran R, Hanley AJG, Raif N, Mirning CR, Connelly PW, Sermer M, Zinman B: Adiponectin and beta- cell dysfunction in gestational diabetes: Pathophysiologic implications. Diabetalogia, 2005;48:993-1001.

Rietberg MB, Brooks D, Uitdehaag BMJ, Kwakkel G: Exercise therapy for multiple sclerosis. The Cochrane Database of Systematic Reviews, 2004, Issue 3.

Rubin BB, Downey GP, Degousee N, Lindsay TF: Cytosolic phosphlipase A2-a is necessary for platelet-acti- vating factor biosynthesis, efficient neutrophil-mediated bacterial killing and the innate immune response to pulmonary infection. J Biol Chem, 2005;280(9):7519-7529.

Sam J, Angoulvant D, Fazel S, Weisel RD, Li R-K: Heart cell implantation after myocardial infarction. Coron Artery Dis, 2005;16:85-91.

Scott HK, Irvine J, Ritvo P, Mann RE: Can psychological interventions reduce mortality rates in patients with coronary heart disease and cancer? A review of randomized trials. Int J Ment Health Addict, 2005;2(2):13-24.

Segev A, Kassam S, Buller CE, Lau HK, Sparkes JD, Connelly PW, Seidelin PH, Natarajan MK, Cohen EA, Strauss BH: Preprocedural plasma levels of C-reactive protein and interleukin-6 do not predict late coronary angiographic restenosis after elective stenting. Eur Heart J, 2004;25:1029-1035.

Segev A, Hegele RA, Lau HK, Sparkes JD, Teitel JM, Chisholm RJ, Strauss BH: Thr325Ile polymorphism of the TAFI gene is related to TAFI antigen plasma levels and angiographic restenosis after percutaneous coronary interventions. Thromb Res, 2004;114(2):137-141.

Segev A, Goldman LE, Cantor WJ, Barr A, Strauss BH, et al: Elevated troponon-I after percutaneous coronary interventions: Incidence and risk factors. Cardiovasc Radiat Med, 2004;5(2):59-63.

Segev A, Nili N, Strauss BH: The role of perlecan in arterial injury and angiogenesis. Cardiovasc Res, 2004;63(4):603-610.

Segev A, Strauss BH: Novel approaches for the treatment of chronic total occlusions. J Interv Cardiol, 2004;17(6):411-416.

~ 58 ~ Sehi M, Flanagan JG, Zeng L, Cook RJ, Trope GE: Relative change in diurnal mean ocular perfusion pressure: A risk factor of the diagnosis of primary open angle glaucoma. Invest Ophthalmol Vis Sci, 2005;46:561-567.

Sehi M, Flanagan JG: The effect of image alignment on capillary blood flow measurement of the neuro retinal rim using the Heidelberg Retina Flowmeter. Br J Ophthalmol, 2004;88:204-206.

Series F, Kimoff J, Morrison D…Floras JS, Bradley TD: Prospective evaluation of nocturnal oximetry for detection of sleep-related breathing disturbances in patients with chronic heart failure. Chest, 2005;127:1507- 1514.

Sidani S, Brooks D, Graydon J, Hall L: Evaluating the effects of music on dyspnea and anxiety: A process- outcome analysis. Int Nurs Perspect, 2004;4:5-13.

Sigal IA, Flanagan JG, Tertinegg I, Ethier CR: Finite element modeling of optic nerve head biomechanics. Invest Ophthalmol Vis Sci, 2004;45:4378-4387.

Simmons CA, Alsberg E, Hsiong S, Kim WJ, Mooney DJ: Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone, 2004;35:562- 569.

Simmons CA, Zilberberg J, Davies PF: A rapid, reliable method to isolate high quality endothelial RNA from small spatially-defined locations. Am Biomed Eng, 2004;32:1453-1459.

Simmons CA, Nikolovski J, Thornton AJ, Matlis S, Mooney DJ: Mechanical strain and mitogen-activited protein kinase signaling independently regulate osteogenic differentiation and mineralization by calcifying vascular cells. J Biomech, 2004;37:1531-1541.

Simmons CA, Grant GR, Manduchi E, Davies PF: Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circ Res, 2005;96:792-799.

Simpson CS, Hoffmaster B, Dorian P: Downward delegation of implantable cardioverter defibrillator decision-making in a restricted resource environment: The pitfalls of bedside rationing. Can J Cardiol, 2005;21:595-599.

Simpson CS, O’Neill BJ, Sholdice MM, Dorian P, et al: Canadian Cardiovascular Society commentary on implantable cardioverter defibrillators in Canada: Waiting times and access to care issues. Can J Cardiol, 2005;21(Suppl A):19-24.

Sioris T, David TE, Ivanov J, Armstrong S, Feindel CM: Clinical outcomes after separate and composite replacement of the aortic valve and ascending aorta. J Thorac Cardiovasc Surg, 2004;128(2):260-265.

Slutsky AS: 2004 Donald F. Egan Memorial Lecture: Ventilator-induced lung injury: From barotraumas to biotrauma. Respir Care, 2005;50(5):646-659.

Sommers GR, Smith CR, Wilson GJ, et al: Association of drowning and myocarditis in a pediatric population: An autopsy-based study. Arch Pathol Lab Med, 2005;129(2):205-209.

~ 59 ~ Somogyi RB, Preiss D, Vesely A, Fisher JA, Duffin J: Changes in respiratory control after 5 days at altitude. Respir Physiol Neurobiol, 2005;145(1):41-52.

Stainsby JA, Sussman MS, Flexman ML, Wright GA: Real-time magnetic resonance with physiologic monitoring for improved scan localization. Magn Reson Med, 2005;53(4):954-959.

Stewart DE, Rolfe DE, Robertson E: Depression, estrogen and the Women’s Health Initiative. Psychosomatics, 2004;45(5):455-457.

Stewart DE, Gucciardi E, Grace SL: Depression. BMC Women’s Health, 2004;25(4):Suppl 1-S19.

Stewart DJ: Bone morphogenetic protein receptor-2 and pulmonary arterial hypertension: Unraveling a riddle inside an enigma? Circ Res, 2005;96:1033-1035.

Sun M, Dawood F, Wen WH, Chin MY, Kirshenbaum L, Liu PP: Excessive tumor necrosis factor activa- tion post-infarction contributes to susceptibility to myocardial rupture and left ventricular dysfunction. Circulation, 2004;110:3221-3228.

Sussman MS, Robert N, Wright GA: Adaptive averaging for improved SNR in real-time coronary artery MRI. IEEE Trans Med Imaging, 2004;28(8):1034-1045.

Tang GH, Fazel S, Weisel RD, Van Arsdell GS, Li R-K: Cardiovascular tissue engineering therapy: So near, so far? Ann Thorac Surg, 2005;79:1831-1833.

Tang GHL, Feindel CM, Gullane PJ, Butany J: Combined cardiac surgery and excision of a retrosternal thyroid mass: A case report. J Card Surg, 2005;20:1-2.

Tang AS, Ross H, Simpson CS, Mitchell LB, Dorian P, et al: Canadian Cardiovascular Society/Canadian Heart Rhythm Society position paper on implantable cardioverter defibrillator use in Canada. Can J Cardiol, 2005;21(Suppl A):11-18

Taylor C, Senchyna M, Flanagan JG, Keikkila L, et al: The role of eIF5A in TNF-a induced apoptosis of lamina cribrosa cells. Invest Ophthalmol Vis Sci, 2004-45:3568-3576.

Tong S, Lingappa JR, Chen Q… Butany J, Comer JA, Monroe SS, et al: Direct sequencing of SARS-coronavirus S and N genes from clinical specimens shows limited variation. J Infect Dis, 2004;190(6):1127-1131.

Toporsian M, Gros R, Kabir MDG, Vera S, Govindarju K, Eidelman DH, Husain M, Letarte M: A role for endoglin in coupling eNOS activity and regulating vascular tone revealed in Hereditary Hemorrhagic Telangiectasia. Circ Res, 2005;96(6):684-692.

Tremblay LN, Slutsky AS: Pathogenesis of ventilator-induced lung injury: Trials and tribulations. Am J Physiol Lung Cell Mol Physiol, 2005;288(4):L596-L598.

Tsang SY, Tsushima RG, Tomaselli GF, Li RA, Backx PH: A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor. Mol Pharmacol, 2005;67(2):424- 434.

~ 60 ~ Tsoporis JN, Marks A, Haddad A, O’Hanlon D, Holly S, Parker TG: S100A6 is a negative regulator of the induction of cardiac genes by trophic stimuli in cultured rat myocytes. Exp Cell Res, 2005;303(2):471-481.

Tsoporis JN, Marks A, Haddad A, Dawood F, Liu P, Parker TG: Expression of S100B post coronary artery ligatin regulates remodeling of mouse myocardium. Circulation, 2005;111(5):598-606.

Tu JV, Pinfold SP, McColgan P, Laupacis A: Access to Health Services in Ontario: ICES Atlas. Toronto: ICES, 2005.

Usui K, Bradley TD, Spaak J, Ryan CM, Kubo T, Kaneko Y, Floras JS: Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure. J Am Coll Cardiol, 2005;45:2008-2011.

Venkataraman ST, Hudson C, Fisher JA, Flanagan JG: The impact of hypercapnia on retinal capillary blood flow assessed by scanning laser Doppler flowmetry. Microvasc Res, 2005;69(3):149-155.

Verma S, Szmitko PE, Weisel RD… Fremes SE: Should radial arteries be used routinely for coronary artery bypass grafting? Circulation, 2004;110:e40-e46.

Villamor E, Kessels CG, Ruijtenbeek K, Van Suylen RJ, Belik J, De Mey JG, Blanco CE: Chronic in ovo hypoxia decreases pulmonary arterial contractile reactivity and induces biventricular cardiac enlargement in the chicken embryo. Am J Physiol Regul Integr Comp Physiol, 2004;287:R642-R651.

Vonder Muhll I, Liu PP, Webb G: Applying standard therapies to new targets: The use of ACE inhibitors and B-blockers for heart failure in adults with congenital heart disease. Int J Cardiol, 2004;97:S25-S33.

Voulgaraki D, Mitnacht-Kraus R, Letarte M, Foster-Cuevas M, Brown MH, Barclay N: Multivalent recom- binant proteins for probing functions of leukocyte surface proteins such as CD200 receptor. Immunology, 2005;115:337-346.

Wang C-H, Li S-H, Weisel RD, Fedak PWM, Hung A, Li R-K, Rao V, et al: Tetrahydrobiopterin deficiency exaggerates intimal hyperplasia after vascular injury. Am J Physiol Regul Integr Comp Physiol, 2005:Epub.

Warrington K, Hillarby MC, Li C, Letarte M, Kumar S: Functional role of CD105 in TGF-b1 signaling in murine and human endothelial cells. Anticancer Res, 2005;25:1851-1864.

Wijesekara N, Konrad D, Eweida M, Jeffereies C, Liadis N, Giacca A, et al: Muscle-specific PTEN deletion protects against insulin resistance and diabetes. Mol Cell Biol, 2005;25:135-1145.

Winer D, Silversides C, Israel N, Rinne C, Change WS, Butany J: Cardiac hemochromatosis in an HFE His63Asp (187C-G) heterozygote. Can J Cardiol, 2004;20(10:971-972.)

Wittnich C, Belanger MP, Askin N, Boscarino C, Wallen JW: Lower liver transplant success in females: Gender differences in metabolic response to global ischemia. Transplant Proc, 2004;36:1485-1488.

Wong AP, Nili N, Strauss BH: Differences in phenotypic modulation, proliferation and matrix protein synthesis in venous and arterial-derived smooth muscle cells: Potential role of decorin. Cardiovasc Res, 2005;65(3):702-710. ~ 61 ~ Yang LL, Arab S, Liu P, Stewart DJ, Husain M: The role of endothelin-1 in myocarditis and inflammatory cardiomyopathy: Old lessons and new insights. Can J Physiol Pharmacol, 2005;83(1):47-62.

Yang L, Kabir G, Gros R, El-Moselhi A, Husain M, Stewart D: Conditional cardiac-specific over-expression of ET-1 in transgenic mice results in an inflammatory cardiomyopathy and heart failure. Circulation, 2004;109:255-261.

Yang P, Santos JM, Nguyen P…Wright GA, Nishimura D, Pauly J, Hu B: Dynamic real-time architecture in magnetic resonance coronary angiography (MRCA) – A prospective clinical trial. J Cardiovasc Magn Reson, 2004;6(4):885-894.

Yang S, Fazel S, Angoulvant D, Weisel RD, Li R-K: Cell transplantation for heart disease: The clinical perspective. Evidence-based Cardiovasc Med, 2005;9:2-7.

Yasuda T, Weisel RD, Kiani C, Mickle DAG, Maganti M, Li R-K: Quantitative analysis of survival of transplanted smooth muscle cell with real-time PCR. J Thorac Cardiovasc Surg, 2005;129:901-911.

Yau TM, Li G, Zhang Y, Weisel RD, Mickle DAG, Li R-K: Vascular endothelial growth factor receptor unregulation in response to cell-based angiogenic gene therapy. Ann Thorac Surg, 2005;79(6):2056-2063.

Zhao YD, Courtman DW, Deng Y, Kugathasan L, Zhang Q, Stewart DJ: Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease. Circ Res, 2005;96(4):442-450. Epub 2005 Feb.

Zhou Z, Rahme E, Tu JV, et al: Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: An evaluation of class effect. CMAJ, 2005;172:1187-1194.

Zhu X, Herzenberg AM, Eskandarian M, Maguire GF, Scholey JW, Connelly PW, Ng DS: A novel in vivo lecithin-cholesterol acyltransferase (LCAT) deficient mouse expressing predominantly LpX is associated with spontaneous glomerulopathy. Am J Pathol, 2004;165:1269-1278.

Zohar R, Zhu B, Liu P, Sodek J, McCulloch CA: Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase 3-independent pathway. Am J Physiol Heart Circ Physiol, 2004;287:H1730- H1739.

Zurawska J, Sze M, Lee JSY, Gotlieb AI: Dynamic Microfilaments and Microtubules Regulate Endothelial Function: IN: Perspectives on Lung Endothelial Barrier Function. Advances in Molecular and Cellular Biology. (Ed. Patterson C), Elsevier, Amsterdam, 2004;35:202-235.

~ 62 ~