Vol. 26 • February 2020 PThe NeAwsletteTr of PaHthologyO and LaboLratoryO MedicineG at WeillI CoSrnell MeT dicine

grant, which has been funded since 2002 and comprises Contents Research Highlights seven academic research institutions in Boston. He has received several awards and honors, including the Edited by David P. Hajjar, PhD Stowell-Orbison Award from the United States and Canadian 1 Academy of Pathology, the Donald S. Coffey Physician- Research Highlights Scientist Award from the Prostate Cancer Foundation and Welcome to Our New Chair, Massimo Loda, MD Massimo, Loda, MD the Distinguished Mentor Award from Brigham and David D .Thompson Professor Women’s Hospital. Dr. Loda was also elected a member of and Chairman 3 of the Department of the Association of American Physicians in 2015. He serves Pathology and Laboratory on several national advisory boards and NIH study sections Our Renowned Pathologists Medicine, Weill Cornell on the Global Stage Medicine; Pathologist-in-Chief, and working groups. NewYork-Presbyteria n/ Dr. Loda completed his undergraduate studies in 1976 at Weill Cornell Medical Center 4 the University of Witwatersrand in Johannesburg, South Faculty Focus Africa, and received his medical degree in 1980 from the University of Milan. In the mid-1980s, Dr. Loda moved to the 5 Welcome to Our New Chair, United States and completed a residency in anatomic pathology at Harvard Medical School, as well as a fellow - Keynotes Massimo Loda, MD ship in anatomic and molecular pathology at Tufts Medical Dr. Massimo Loda, an inte rnationally renowned molecular Center. Dr. Loda was appointed to Ha rvard Medical School’s 7 pathologist, is our new Chai rman and Pathologist-in-Chief. Dr. faculty in 1992, rising through the ranks to become a Newly Awarded Loda was recruited to Weill Co rnell Medicine and NewYork- Professor of Pathology in 2006. He joined the Dana-Farber Pathology Grants Presbyte rian/Weill Co rnell Medical Center from Dana-Farber Cancer Institute in 1998, where he in 2016 became Chief Cancer Institute in Boston, where he was Chair of the of the Division of Translational and Molecular Oncologic 8 Depa rtment of Oncologic Pathology. Pathology. Congratulations An acclaimed physician-scientist with a focus on urologic Dr. Loda, Professor of Pathology and Laboratory Medicine, Dr. Rhonda K. Yantiss oncology, Dr. Loda uses biochemical and genomic approaches joined Weill Cornell Depa rtment of Pathology and Labora tory to investigate the mechanisms by which prostate cancer Medicine in February 2019. 9 hijacks cell metabolism to allow tumors to flourish. Unlike Residents’ Research Day healthy cells, prostate tumors rely on – and thus create – fat, BIOLOGY OF PROSTATE CANCER According to Massimo Loda, MD or lipids, for energy. Dr. Loda discovered that the molecular 10 pathway responsible for that metabolic activity renders tumor For many years, Dr. Massimo Loda and his research team Welcome New cells vulnerable to targeted treatments, and has identified two have studied the links between the regulation of Resident s/ Fellows such drugs that exploit it with few clinical side effects. Dr. metabolomics and the progression of prostate cancer. Department Leadership Loda has also identified prostate cancer biomarkers that can Today, metabolomics is defined as the quantitative meas - Appointment s/ Promotions predict therapeutic e fficacy. urement of the metabolic response to external stimuli or Dr. Loda is a board-ce rtified pathologist and physician- genetic alterations. It can also detect and quantify low- 11 sci entist with expe rtise in genitourinary cancers, pa rticularly mol ecular weight metabolites produced by living cells. Faculty Publications prostate cancer. He has published more than 360 scholarly The metabolites of living cells are seen as the end prod - in 2019 papers in jou rnals, including Nature and its specialized pub - ucts of the biological hierarchy, starting with activated li cations, Cell, Cancer Cell, New England Jou rnal of Medicine, genes (genome) and extending over the collection of gene Proceedings of the National Academy of Sciences, and Jou rnal transcripts (transcriptome) and proteins (proteome). of Clinical Oncology. Dr. Loda has been consistently funded by Metabolic alterations can occur as a consequence of the National Institutes of Health, the Depa rtment of Defense, genet ic events. Alternatively, metabolic alterations are the American Cancer Society and other organizations. He is pri mary events in cancer but require genetic alterations principal investigator of a National Cancer Institute Specialized in critical pathways for oncogenesis to occur (e.g. isocitrate Program of Research Excellence (SPORE) prostate cancer dehydrogenase mutations). Either way, Professor Loda Research Highlights Figure 1. Prostate cells increased both the synthesis and utilization of fatty acids (FAs) continued from page 1 during cellular transformation and prostate cancer progression. (A) Simplified illustration Exogenous FAs and lipids A LDL of FA synthesis and associated pathways. FATPs CD36 believes that genetic alterations and altered meta - A Glucose LDLR FABP Sources of carbon for de novo FA synthesis bolic pathways go hand in hand in a tumor cell- GLUT derive primarily from glucose and glutamine. Cholesterol In harsh environments, acetate can also be spe cific manner. Thus, simultaneous targeting of Glucose Prostaglandins, used as a carbon source. Once synthesized,

Thromboxanes s d i p selected metabolic enzymes and “driving” onco - G6P i L Intracellular (Poly)unsaturated de novo FAs undergo elongation and satura tion Triacylglycerides, x FAs Phosphoglycerides e FAs l p

m ELOVL modifications. FAs are also provided by diet genes may be a cancer cell-selective therapeutic G3P Sphingolipids o FADS C

Cardiolipids Monounsaturated and they can be uptaken from the circulation approach. FAs Pyruvate through transporters, binding proteins, or SCD Several years ago, he and his colleagues discov - ELOVL passive transport. Diet is the only source of Malonyl-CoA Acetyl-CoA ACC FASN Palmitate essential FAs. Once in the cells, FAs are ered that USP2a binds to and stabilizes fatty acid Oxaloacetate ACLY Citrate Citrate Acetyl-CoA incorporated in more complex structural, Malate ACSS2 TCA Cycle Isocitrate synthase (FASN) by preventing its degradation. This Isocitrate Fumarate Acetylation Acetate storage lipids, and inflammatory mediators α-KG Succinate Mevalonate or (B) oxidized in peroxisomes or mitochon - prompted them to initiate a research program α-KG pathway Succinyl-CoA Internal acetate sources MCT dria to produce energy. GLUT, glucose trans - focused on FASN. Having interests in the etiology Glutamate Acetate porter; LDL, low-density lipoprotein; LDLR, Cholesterol and and pathogenesis of prostate cancer (PCa), his lab - Glutamine Steroid Synthesis low-density lipoprotein receptor; FATPs, oratory investigated the expression of FASN in PCa fatty-acid transport proteins; FABP, fatty- SLC1A5 acid-binding protein; ACLY, ATP citrate lyase; GGlutaminelutamine by immunohistochemistry as well as gene expres - ACC, acetyl-CoA carboxylase; FASN, fatty BB Very long FAs acid synthase; ACSS2, cytoplasmic acetyl- sion profiling demonstrating that FASN is over- Shortened FAs Peroxisome CoA synthetase; SCD, stearoyl-CoA desaturase; ex pressed in aggressive prostate carcinomas. FAs NADH ETC Carnitine Acyl-CoA ELOVL, fatty acid elongase; ␣-KG, ␣-ketog -

β-oxidation FADH2 Since it has been reported that FASN expression is Acyl-CoA CPT1 lutarate; G3P, glyceraldehyde-3-phosphate; CPT2 G6P, glucose-6-phosphate; TCA, tricarboxylic highest in androgen-independent bone metastatic ATP Acylcarnitine Acylcarnitine Carnitine acid; MCT, monocarboxylate transporter; disease, they set out to determine whether it con - Carnitine CPT1, carnitine palmitoyltransferase I; CPT2, fers a growth advantage to PCa. Using genetically carnitine palmitoyltransferase II; NADH, engineered human prostate epithelial cells infected reduced nicotinamide adenine dinucleotide; FADH2, reduced flavin adenine dinucleotide; with FASN, they established that FASN can act as a Advanced Online Article. Cite this article as Cold Spring Harb Perspect Med ETC, electron transport chain; ATP, adenosine PCa. Subsequently, Dr. Loda and his colleagues doi: 10.1101/cshperspect.a030569 triphosphate. showed that FASN ge rmline polymorphisms are significantly associated with risk of lethal PCa. G2/M may be therapeutically exploited for hyper - Sci USA 2018. PubMed Significant interactions of BMI with FASN polymor - Hamid AA, Gray KP, Shaw G, MacConaill LE, Evan C, proliferative diseases such as cancer. phisms and FASN tumor expression suggest FASN Bernard B, Loda M, Corcoran NM, Van Allen EM, Professor Loda’s laboratory at Weill Co rnell Medicine Choudhury AD, Sweeney CJ. Compound Genomic as a potential link between obesity and poor PCa Alterations of TP53, PTEN, and RB1 Tumor Suppressors has now been established, and he continues to hit in Localized and Metastatic Prostate Cancer. Eur Urol outcome. Dr. Loda reasons that FASN inhibition major milestones in understanding the pathogenesis 2018. PubMed could reduce PCa-specific mortality, particularly in Wang Z, Cao S, Morris JS, Ahn J, Liu R, Tyekucheva S, of Prostate Cancer. Gao F, Li B, Lu W, Tang X, Wistuba II, Bowden M, Mucci overweight men. Relevant Publications L, Loda M, Parmigiani G, Holmes CC, Wang W. Dr. Loda recently expanded the analysis of metab - Transcriptome Deconvolution of Heterogeneous Tumor Abida W, Cyrta J, Heller G, Prandi D, Armenia J, Samples with Immune Infiltration. iScience 2018; olism in PCa to assess the global metabolic profile Coleman I, Cieslik M, Benelli M, Robinson D, Van Allen 9:451-460. PubMed EM, Sboner A, Fedrizzi T, Mosquera JM, Robinson BD, by GS/MS in immortalized prostate epithelial cells Elfandy H, Armenia J, Pederzoli F, Pullman E, Pertega- De Sarkar N, Kunju LP, Tomlins S, Wu YM, Nava Gomes N, Schultz N, Viswanathan K, Vosoughi A, and transgenic mice, comparing Akt and Myc as the Rodrigues D, Loda M, Gopalan A, Reuter VE, Pritchard Blattner M, Stopsack KH, Zadra G, Penney KL, CC, Mateo J, Bianchini D, Miranda S, Carreira S, Mosquera JM, Tyekucheva S, Mucci LA, Barbieri C, driving oncogenes. The results were then applied Rescigno P, Filipenko J, Vinson J, Montgomery RB, Loda M. Genetic and Epigenetic Determinants of to human tumors previously categorized as to the Beltran H, Heath EI, Scher HI, Kantoff PW, Taplin ME, Aggressiveness in Cribriform Carcinoma of the Schultz N, deBono JS, Demichelis F, Nelson PS, Rubin Prostate. Mol Cancer Res 2018. PubMed sta tus of these oncogenes. His findings show starkly MA, Chinnaiyan AM, Sawyers CL. Genomic correlates Stopsack KH, Gonzalez-Feliciano AG, Peisch SF, different metabolic profiles resulting from these of clinical outcome in advanced prostate cancer. Proc Downer MK, Gage RA, Finn S, Lis RT, Graff RE, Natl Acad Sci USA 2019; 116:11428-11436. PubMed Pettersson A, Pernar CH, Loda M, Kantoff PW, Ahearn oncogenes and signatures that could be applied to Stopsack KH, Whittaker CA, Gerke TA, Loda M, Kantoff TU, Mucci LA,. A Prospective Study of Aspirin Use and human tumors and exploited as imaging tools. He PW, Mucci LA, Amon A. Aneuploidy drives lethal Prostate Cancer Risk by Status. Cancer Epidemiol progression in prostate cancer. Proc Natl Acad Sci USA Biomarkers Prev 2018; 27:1231-1233. PubMed has also shown that inhibition of de novo lipogene - 2019; 116:11390-11395. PubMed Ahearn TU, Peisch S, Pettersson A, Ebot EM, Zhou K, Randall EC, Zadra G, Chetta P, Lopez BGC, Syamala S, sis is the predominant downstream effector of Graff RE, Sinnott JA, Fazli L, Judson GL, Bismar TA, Basu SS, Agar JN, Loda M, Tempany CM, Fennessy FM, Rider JR, Gerke T, Chan JM, Fiorentino M, Flavin R, AMPK-mediated inhibition over mTORC1 (EMBO Mol Agar NYR. Molecular Characterization of Prostate Sesso HD, Finn S, Giovannucci EL, Gleave M, Loda M, Cancer with Associated Gleason Score Using Mass Li Z, Pollak M, Mucci LA, . Expression of IGF/insulin Med, 2014). Spectrometry Imaging. Mol Cancer Res 2019. PubMed receptor in prostate cancer tissue and progression to Finally, Dr. Loda’s laboratory recently showed that Zadra G, Ribeiro CF, Chetta P, Ho Y, Cacciatore S, Gao lethal disease. Carcinogenesis 2018. PubMed X, Syamala S, Bango C, Photopoulos C, Huang Y, Sowalsky AG, Ye H, Bhasin M, Van Allen EM, Loda M, the inhibition of fatty acid synthesis arrested the Tyekucheva S, Bastos DC, Tchaicha J, Lawney B, Uo T, Lis RT, Montaser-Kouhsari L, Calagua C, Ma F, Russo cells at G2/M notwithstanding the presence of D'Anello L, Csibi A, Kalekar R, Larimer B, Ellis L, Butler JW, Schaefer RJ, Voznesensky OS, Zhang Z, Bubley GJ, LM, Morrissey C, McGovern K, Palombella VJ, Kutok Mont gomery B, Mostaghel EA, Nelson PS, Taplin ME, abundant fatty acids in the media. Their results JL, Mahmood U, Bosari S, Adams J, Peluso S, Dehm Balk SP. Neoadjuvant-intensive androgen deprivation suggest that de novo lipogenesis is essential for cell SM, Plymate SR, Loda M. Inhibition of de novo therapy selects for prostate tumor foci with diverse lipogenesis targets androgen receptor signaling in subclonal oncogenic alterations. Cancer Res 2018. cycle completion. This “lipogenic checkpoint” at castration-resistant prostate cancer. Proc Natl Acad PubMed n

2 www.cornellpathology.com Our Renowned Pathologists on the Global Stage

p Dr. Rhonda Yantiss (front-middle) Dr. Yantiss was the guest GI Pathology speaker at the Pa thotim 2019 Recent Advances in GI, GU, and Placental Pathology Seminar in Timisoara, Romania.

p Dr. Matthew Greenblatt (middle-left) after p Dr. Amy Chadbu rn (2nd from left) The Great Wall of Xian – members p Dr. Yao-Tsen g Chen giving the plenary lecture at the Bone Biology Forum of the Workshop Panel and speakers from the 1st Joint Chinese Society for retu rned to Taiwan in January of Japan with colleagues Hiroshi Asahara and Ryo Hematopathology (CSHP)/SH Workshop (left to right) Drs. Yaso Natkunam to vote in the presidential cam - Nakamichi, August 2019 and (right) at podi um (Stanford), Amy Chadburn (Weill-Cornell), Girish Venkataraman (U of paign (with a happy ending)! speak ing at the annual International Chinese Chicago) and Paul Rubinstein (Cook County Hospital, Chicago). Dr. Musculoskeletal Research Society in Shenzhen China, Chadbu rn was part of the Workshop Panel and lectured on “HIV and HHV8- August 2019. related Lymphomas” at the 2 day meeting held in Xian, China, October 19- 20, 2019. Other members of the depa rtment who presented at the meeting included Mihn Mays, Hematopathology Fellow, and Eve Crane, Hematopathology Attending.

1 2 3

p Dr. Genevieve Crane exploring the Muslim p Dr. Momin Siddiqui 1. (2nd from left) was a Seminar Faculty and Speaker on Pancreas Cytology. Quarter in Xi’an, China following the first joint workshop 9th Annual Siriraj -Johns Hopkins, Cytopathology Course, Bangkok, Thailand, July 12th, 2019; 2. (2nd from between the two countries’ hematopathology societies. right) Dr. Siddiqui was a Congress Faculty and Speaker at The 20th International Congress of Cytology, Xi’an was the starting point for the Silk Road, bringing Sydney, Australia, May 5th-9th, 2019; 3. (far right) Dr. Siddiqui was a Seminar Faculty and Speaker at the a mix of cultures and persisting today as a vibrant food 2019 Croatian Society of Clinical Cytology and American Society of Cytopathology Meeting, Zagreb, Croatia. and social scene. September 21, 2019.

3 and Laboratory Medicine in July 2019. Dr. Arryn Craney, PhD joined Faculty Focus Solomon graduated from the combined MD/PhD the Department as Assistant Program at the University of California, San Diego. Professor of Pathology and by Massimo Loda, MD He received his PhD from the Scripps Research Laboratory Medicine in Institute in July 2011 and his MD from the August 2019. Dr. Craney is a Welcome New Faculty University of California, San Diego in June 2013. Clinical Microbiology Fellow in Subsequently, he completed residency training the Department of Pathology in both Anatomic and Clinical Pathology at the and Microbiology at the University of Nebraska HEMATOPATHOLOGY University of California, San Diego. This was fol - Medical Center. She obtained her BSc at the Anna Nam, MD joined the lowed by an Oncologic Pathology Fellowship at University of Waterloo, Canada, and her PhD department as Instructor of Memo rial Sloan Kettering Cancer Center where he in Biochemistry and Biomedical Sciences at Pathology and Laboratory is now currently completing a Molecular Pathology McMaster University, Canada, where she investi - Medicine July 2019. Dr. Nam Fellowship. During his residency, he received the gated metabolism in Streptomyces coeli color . received her Bachelor’s Saltzstein Award for patient-oriented service in Subsequently, she conducted a highly productive Degree from Davidsons College 2015 and has been editor of the monthly postdoctoral fellowship in the Romesberg in 2008. While there she excelled as a student, “Molecular Pathology” column in CAP today since Laborato Velu,ry at The Scripps Research Institute received mul tiple awards and graduated Phi Beta 2014. where she focused on anti microbial resistance. Kappa. She received her medical degree from Dr. Craney has continued to expand upon her University of Missouri School of Medicine, where Priya Velu, MD, PhD joined interest surrounding anti microbials and antimicro - she received cle rkship honors in multiple rotations the Depa rtment as Assistant bial resistance throughout her Fellowship and is and graduated Alpha Omega Alpha. Dr. Nam took Professor of Pathology and excit ed to bring her expertise to bear in New York two years off from medical school to serve as a Laboratory Medicine in August City, a bas tion of antimicrobial resistance. Howard Hughes Medical Institute-NIH Research 2019. She received her Scholar under the mentorship of Dr. Jung-Hyun bach elor of arts degree in Jenny Yang, MD, PhD Park. She completed her training in Anatomic bio physics from The Johns joined the Department as Pathology, followed by a one year fellowship Hopkins University in 2005, and then received Assistant Professor of Pathol- in Hematopathology, followed by a Molecular her MD, PhD in neuroscience from the University ogy and Laboratory Medicine Pathology Fellowship, all with us. During that time, of California, San Diego in 2014. After which, in September 2019. She she had the oppo rtunity to spend time in the research she moved to the University of Pennsylvania received her bachelor of sci - laboratory of Dr. Dan Landau where she has excelled. where she was a resident in Clinical Pathology, ence degree and master of She was awarded the Alumni Counsel Distinguished and a post-doctoral research fellow in Precision arts degree from the University of California, Los Housestaff Award for Pathology from Weill Cornell Medicine and Molecular Genetic Pathology in Angeles, and MD/PhD from Harvard Medical Medicine in 2018 and the American Society of the Department of Pathology at the University School. After which, she became a clinical Hematology Abstract Achievement Award in 2018 of Pennsylvania. Dr. Velu is certified by the patholo gy res ident and pathology fellow at as well. American Board of Pathology in Clinical Pathology and is board eligible in molecular Columbia University Medical Center. She is board - Sanjay Patel, MD, MHA genet ic pathology. She spends her time in certified in Clinical Pathology. She was a visiting joined the Department as Molecular and Genomic Pathology, and research. fel low at Rockefeller University. Dr. Yang has been Assistant Professor of Path- Her work f ocuses on can cer biology as well as the recip ient of several awards from Harvard ology and Laboratory Medicine areas of neuro science. Medical School, the NIH, and UCLA; and, she was a in July 2019. He received Howard Hughes research fellow from 2004-2006. his bachelor of sci ence LABORATORY MEDICINE degree from the University of Sab rina Racine-B rzostek SURGICAL PATHOLOGY Rochester in 2007, and then his master’s degree of MD, PhD joins the Depart- Lihui Qin, MD, PhD joined science and public health in 2009; after which, he ment as Assistant Professor the Department as Associate earned an MD from Saint George’s University in the of Pathology and Laboratory Professor of Pathology and West Indies in 2013. He did his residency in Medicine in July 2019. Dr. Laboratory Medicine. She Anatomic and Clinical Pathology at the University of Racine-B rzostek received her received her medical degree Wisconsin hospital and clinics in Madison, bachelor of sci ence degree from Boston College from Beijing Medical Univer- Wisconsin, finishing in 2017. His fellowships were in 2000, and her MD and PhD from Stony Brook sity in her native China in 1986. After prac ticing completed at the Brigham and Women’s Hospital in University School of Medicine in Stony Brook, occupational med icine in China for four years, she 2018 and 2019. Dr. Patel is board-certi fied in New York in 2013. She did an anatomic and immigrated to the United States and matriculated anatomic pathology, clinical pathology, and clinical pathology residency pro gram at in the PhD program at the Medical University of hematopathology. In the past two years, Dr. Patel Montefiore Medical Center at the Albert Einstein South Carolina. She received a PhD under the has received academic honors and awards includ - College of Medicine in the Bronx, New York men torship of Dr. J. Bromberg from that institution ing the David Y. Mason Award from the European Moreover, she became their chief resident and in 1994. She subsequently joined Dr. Bromberg at Association Hematopathology and from the then moved on to the New York Blood Center and the University of Michigan where she served as a Benjamin Castleman Award from the United States Weill Co rnell Medicine to serve as a transient post-doctoral research fellow for five years. She and Canadian Academy of trans fusion medicine fellow in 2018. Dr. Racine- entered the pathology residency training program Pathology. Brzostek also served as a research assistant at the Mount Sinai School of Medicine in 1999 with Dr. Anthony Hollenberg at the Beth Israel and completed her training in anatomic pathology MOLECULAR AND GENOMIC Deaconess Medical Center from 2000 to 2001. At at that institution in 2002. Subsequently, she com - PATHOLOGY Stony Brook, she was involved in the medical pleted a fellowship in gastrointestinal and trans - James Solomon, MD, PhD scientist training program and has given many plantation pathology at the Mount Sinai School joined the Depa rtment as didactic lectures there as well as here at Weill of Medicine in 2003. She is board-certified in Assistant Professor of Pathology Co rnell. anatomical pathology. n

4 www.cornellpathology.com Zone Edition held in association with the LFR Congress on Hematologic Malignancies. Most Mar ginal Zone Lymphoma Scientific Workshop. This re cently she traveled to Lima, Peru, as part of the Keynotes case presentation was subsequently publis hed as par t plan ning committee for the AMC PEACH Trial where by Domenick J. Falcone, PhD of the Fall Edition of the LFR newsletter, Frontline. she lec tured the His tologic Criteria, Pitfalls, Assess - Early May saw Dr. Chadbu rn in San Francisco at the ment and Cen tral Review for the trial. ACSR (AIDS Cancer Specimen Resource) Advisory Board G Dr. Genevieve Crane was named to the G Meeting. On her return she lectured on Opportunistic Dr. Rebecca Baergen presented three lectures Pathologist’s 2019 Power List, as a top trailblazer in Infections and Lymphomas, to the Arthur Ashe Fellow - while attending the 34th Annual Conference on the field and recognized on the cover of the Septem - ship Recipients who are individuals that spend a month Obstet rics, Gynecology, Perinatal Medicine, Neo- ber 2019 Pathologist Magazine. She was an invited at WCM learning about AIDS and AIDS treatments. na tology and the Law held in Maui, Hawaii (January, guest faculty at the European Bone Marrow Working Later in May she was the Grand Rounds speaker at 2018): “Adverse Pregnancy Outcome: Benefits and Group XIV Inte rnational Course and Workshop on Mayo Clinic Jacksonville, FL, where she talked on Limitation of Placental Pathology;” “Maternal and Bone Marrow Pathology, and lectured as part of the “Post-Transplant Lymphoproliferative Disorders.” Fetal Vascular Malperfusion;” and Potential Medical Foundation in Bone Marrow Pathology Course: In June, Dr. Chadbu rn traveled to Poland where she and Legal I mplications of Inflammatory Lesions of the “Primer for diagnosing cytopenia – practical guide - gave 5 lectures and 2 case seminars at the “Update Placenta.” In March 2018, she attended the Work - lines for diagnosing myelodysplasia and reactive in Hematopathology” 3-day course held in Warsaw. shop for Society for Pediatric Pathology Annual mimickers,” in Frankfurt, Germany. She also gave There she lectured on Immunodeficiency-related Spring Meeting in Vir ginia, where she presented a two case-based platform presentations as part of Lymphoproliferative Disorders, T-cell Lymphomas, workshop on:“What the placenta can tell us.” In June, this workshop. Dr. Julia Geyer was on the scientific Diffuse Aggressive B-cell Lymphomas, Plasma Cell Dr. Baergen traveled to Glasgow, Scotland to attend committee for this meeting and also presented as Neoplasms and the Spleen. In early August, Dr. Chad- the Interna tional C onference on Stillbirth, SIDS and part of the Foundations Course. Dr. Crane’s research bu rn lectured as part of the The Papanicolaou and Baby Sur vival, where she presented: “Interpreting the on HHV-6 with Dr. Ethel Cesarman resulted in a plat - Frost 2019 Cytopathology Tutorial: A Co rnell and Placental Pathology Report.” Also in June, she pre - form presentation in the “Hot Topics” section of the Johns Hopkins Partnership in Excellence. The title of sented “Placental Pathology and Adverse Outcome – 11th International conference on HHV-6 & HHV-7, her lecture for this meeting was “Challenging Lym - an up date” at the American Conference Institute, Quebec City, Canada as well as pilot grant to Dr. Crane phoid Lesions – The Hematopathology Consultation” Philadelphia, PA. from the HHV-6 Foundation to continue this work. Dr. where she presented on how to optimize small G Crane and Dr. Chadbu rn presented a short course at It has been a busy year for Dr. Amy Chadbu rn tis sues for the diagnosis of lymphoid and myeloid the ASCP Annual Meeting in Phoenix, AZ in September as she has given a number of lectures and talks lesions. She then went to Anaheim, CA, for the 2019 titled, “Emerging trends in immunosup pression- in dif ferent areas of the country and the world. American As sociation for Clinical Chemistry (AACC) related lymphoproliferative disease, optimizing patient Jan uary started off with a trip to Florida where she annual meeting where she lectured on “Hemoglobin care with insight from clinical and molecular data,” lectured on “Immunodeficiency-related Lymphopro - Electro phoresis,” pre senting the work-up of hemoglo - which was one of the top 5 most attended courses liferative Disorders in the Neoplastic Hematopathol - bin opa thy cases seen here at NYP-WCM, partnering of the meeting. Dr. Crane together with division ogy Course.” As it was the last year that Dr. Daniel with a clinical chemist who discussed the technical col leagues at Weill Cornell had multiple cases Knowles, our fo rmer chairman, was director of the aspects of testing. In Septem ber, she presented a ac cepted for discussion at the 1st Joint Workshop course, it was a great honor to be able to participate. course with Dr. Genevieve Crane , also of the Division between the Chinese So ciety for Hematopathology In March, Dr. Chadburn traveled to Washington, DC, of Hematopathology, on “Emerging Trends in at the Society for Hematopathology in Xi’an, China. for two meetings. The first was the AIDS Malignancy Im munosuppression-related Lymphoproliferative A case submitted together with current fellow Dr. Consortium International Pathology Meeting where Disease, Optimizing Patient Care with Insight from Minh Mays was se lected for a p latform and presented she spoke on “Lymphomas in the Setting of HIV Clinical and Molecular Data.” This course was one by Dr. Mays at this inaugural event focusing on Infection” and “A Practical Approach to Immuno his to- the best attended sessions at the 2019 American infectious agent re lated lymphoproliferative disease. chemistry.” This meeting was attended by indi vid- So ciety of Clinical Pathology Annual Meeting. Dr. Crane con tinues to serve on the editorial board uals from several countries in Africa and South In addition, Dr. Chadburn served on the expert of multiple journals and was recently promoted to America. Following this meeting Dr. Chadburn at - panel for the The 1st Joint Chinese Society of Deputy-Editor-in-Chief of PathologyOutlines.com, the tended the USCAP meeting where she had 3 scien - Hematopathology – Society of Hematopathology largest online pathology resource in the world. tific proj ects presented as posters with residents and Workshop held in October 19 and 20. This was a 2- other departmental faculty. In addition, she, with Dr. day workshop held in Xian, China, where cases were G In this past academic year, Dr. Annarita Di Ethel Cesa rman from our department with two other presented in 4 different categories including chronic Lorenzo was an invited speaker at the University of individuals from the University of Miami gave a short EBV infections and borderline lymphoproliferations, Alabama at Bi rmingham, at King’s College of London, course entitled “Viral-Associated Lymphoproliferative EBV-related lymphomas, HIV and HHV8-related lym - Cardiovascular Division, and Neuromed/University Lesions: A Rational Approach.” She was also the phomas and other infectious agents. In addition, of Rome “La Sapienza” where she discussed her moderator for the Hematopathology Night Case Con - there was a multidisciplinary case presentation re cently published work on the role of sphingolipids ference Session, which received excellent reviews. ses sion, where Dr. Mihn Mays, hematopathology in a new model of coronary artery atherosclerosis In April, Dr. Chadbu rn had a case accepted and fel low, with Drs. Crane, Chadbu rn, Geyer and Tam , and myocardial infarction. She gave a talk at the pre sented as a podium talk at the European Bone presented a case of “Extra-nodal NK/T-cell Lym - FEBS Special Meeting in Sphingolipid Biology and at Mar row Working Group meeting held in Frankfurt, phoma Arising in a Patient with Concurrent Hepatitis Hypertension Scientific Session AHA on how specific Germany. She also presented a case of “Marginal B Viremia.” Dr. Chadburn also gave a plenary lecture sphingolipids control blood pressure homeostasis. Zone Lymphoma in a Patient with Autoimmune on “HIV and HHV8-related Lymphomas.” Back in New She was a member of the organizing committee for Dis ease and Iatrogenic Immune Suppression” in York, Dr. Chadburn lectured on “Interpreting Bone the 10th International Conference on the Biology, conjunction with Dr. John Allan from the Lymphoma Marrow Biopsy/Immunopathology Reports” to the Chemistry and Therapeutics Applications of Nitric Group at WCM at the Lymphoma Research Foundation nurse practitioners and physician assistants at the Oxide. She also served as an ad hoc reviewer on AHA (LFR) 2019 New York Lymphoma Rounds: Marginal 2019 Lymphoma & Myeloma: An International and NIH study sections. continued on page 6

5 Guangzhou University (August 2019) on the same 29- October 2); the Second Annual Cornell Cancer Keynotes topic. He spoke at the European Calcified Tissue Re search Symposium in Ithaca on October 11; the So ciety annual meeting in Budapest (May 2019) on In ternational Lymphoma and Myeloma Congress in continued from page 5 the discovery of a novel angiogenic factor in bone, New York City on October 2 5th; and the European SLIT3, and conducted a session at this meeting on So ciety of Hematology Mantle Cell Lymphoma – Now how to work with and define skeletal stem cells. He and Beyond Conference in Rome, Italy (November 8th), G Dr. Yi-Chieh Nancy Du ’s lab focuses on under - was awarded a 2019 Pershing Square Sohn Prize in and she chaired a session on “ Lymphoma—Genetic/ standing cancer metastasis in order to develop tar - Cancer Research to study how different skeletal stem Epigenetic Biology: Lymphoma Genomics and geted therapies. Dr. Du served as an ad-hoc reviewer cells may have different capacities to support tumor Mech anisms of Lymphomagenesis” at the ASH on two NIH study sections and a reviewer for Natural cells metastasizing to bone. meet ing (December 7-10). Sciences and Engineering Research Council of G Dr. David Ha jjar was appointed Senior Advisor G In June 2019, Dr. Cynthia Magro along with Canada. Dr. Du was an invited speaker at the 5th NCI- to the Dean/Provost of Medical Affairs at Co rnell as her colleagues Dr. Mihm and Dr. Crowson gave their Pancreatic Cancer Symposium, NIH and University of well as Executive Vice Chair of the Depa rtment of annual comprehensive Dermatopathology course Maryland Greenbaum Comprehensive Cancer Center. Pathology and Laboratory Medicine at WCM. for the American Society for Clinical Pathology G (ASCP) meeting held in Seattle, WA. Dr. Magro gave Dr. Domenick J. Falcone received an Award G 2019 was a special 15 lec tures during the weeklong course discussing for Excellence in Medical Education for developing a year for Dr. Selina di verse topics in the field of Dermatopathology. comprehensive set of interactive exercises in organ- Chen-Kiang and her She continues her work as a section editor for based histology, and in recognition of his role as an team. For her innova - Der matopathology for the online Journal, The educator in the Heath, Illness and Disease course tive and seminal Der matologist. (June, 2019). Dr. Falcone continues to serve as vice- con tributions to de - chair of the Executive Curriculum Committee and veloping CDK4/6 in - G Dr. Sanjay Patel has received the followin g co- director of the Essential Principles of Medicine hibitor as a cancer no table awards: David Y. Mason Award from the (EPOM) course. He serves as basic science theme therapy, Dr. Chen-Kiang Eu ropean Association for Haematopathology leader for the medical college curriculum, and leader was hon ored by the (Octo ber 2018), Benjamin Castleman Award from the of the Injury, Infection, Immunity and Repair learning Leukemia and Lym - United States a nd Canadian Academy of Pathology unit of the EPOM course. In December 2019, Dr. Falcone phoma So ciety at the (March 2019) and the Poster of Distinction from tr aveled to Doha, Qatar to teach the first year students Crim son Ball in New the Depa rtments of Pathology, Brigham and at Weill Cornell Medicine-Qatar, and review the York City on April 24. Dr. Selina Chen-Kiang (left) Women’s and Massachusetts General Hospitals/ with her husband and daughter. course progress with the WCM-Qatar faculty. Dr. Christina Lee, a Harvard Med ical School (May 2019). clinical fellow with Dr. Chen-Kiang was selected for G Dr. Hanna Rennert has established a collabo - the Conquer Cancer Foundation of American Society ration with the industry to study the genomic profile of Clinical Oncology/Frist Family Endowed Young of renal cyst epithelial cells derived from patients In vesti gator Award for her proj ect entitled “Longi - with autosomal dominant polycystic kidney disease tudinal Genomic analysis of Tumor-Immune Cell in - (ADPKD), using advanced genomic sequencing teraction in targeting CDK4 in mantle cell lymphoma” methodologies i ncluding whole exome and whole in July, and as a Lymphoma R esearch Foundation genome sequencing. She was invited to serve on Scholar in LRF Clinical Research Mentoring Program Ver tex Advisory Board f or ADPKD in April 2019 in for “Dual CDK4/6 and immune checkpoint inhibitor Dr. Domenick J. Falcone received an Award for Excellence Boston, MA. The purpose of this board was to discuss therapy in indolent non-Hodgkin L ymphoma in in Medical Education for developing a comprehensive set the genetics of human renal cysts, especially with of interactive exercises in organ-based histology, and in No vember. Nicole Zhao, a summer inte rn with Dr. recog nition of his role as an educator in the Heath, Illness and re gard to somatic mutations and how this influences Chen-Kiang from Stony Brook University, won an Disease course. (pictured 2nd from left Dean Augustine choice of therapeutic approach. Additionally she has M.K. Choi and 2nd from right Domenick J. Falcone). Outstanding Abstract Accomplishment Award from validated an ultra-deep next-generation sequencing the American Society of Hematology and gave an G Dr. Paula Ginter was an invited speaker at The assay for detecting and monitoring of low-frequency oral presentation on “Disrupting GRINL1A Association 3rd Annual International Symposium: Improving somatic mutations in c irculating cell-free tumor DNA with Cereblon Accelerates IKZF1/3 Degradation and Breast Cancer Management and Outcomes in Africa, in lung cancer patients. A poster describing this work IMiD Killing of MCL Cells by CDK4/6 I nhibition” at the August, 2019, Enugu, Nigeria. The title of her pres - has been presented at the Association for Molecular Annual ASH meeting in Orlando Florida (December 7- entation was “Processing of Breast Tissue for Optimal Pathology annual meeting in November 2018 in 10). Dr. Chen-Kiang continued to serve on the H&E, IHC and RNA/DNA Extraction and Sequencing.” San Antonio, TX. She also mentored PYG4 resident, Amer ican Society of Cancer Research Basic Cancer Re becca Marrero Rolon who had a podium presen - G In 2019, Dr. Matthew Greenblatt was an Research Fellowship Review Committee. She was tation, at ACLPS in June 2019 in Salt Lake City, Utah, in vited speaker at the University of Michigan Center in vited to give a keynote lecture on “Longitudinal entitled “Clinical Utility of a Laboratory Developed for Organogenesis (October 2019), the Rolanette and scRNA-seq analysis of tumor-immune interaction in BKV Viral Load Assay for Predicting BKV Associated Berdon Lawrence Bone Disease Program of Texas lymphoma therapy” at the Annual Waldenstrom Nephropathy in Kidney Trans plant Patients.” Finally, Roadmap Symposium (April 6-7); speak at the Meyer (September 2019), the Inte rnational Chinese Musculo- Dr. Rennert has been a member of the AMP Genomic Cancer Center Overseer’s meeting on May 1 and skeletal Research Society Annual Meeting, and the Guideless for Molecular Genetic Pathology fellows Re treat on May 3rd, the New York Genome Center on Bone Biology forum of Japan (August 2019), where Working Group. he discussed his recent publication on the identity of June 4th; at the Hematology-Oncology Grand Rounds the periosteal stem cell. He also gave the YueJin at Knight Cancer Center at Oregon Health Science G Dr. David Rickman was an invited speaker lec ture in life sciences at Xiamen University (August University on June 12th; the 5th International RB at the Feinberg School of Medicine, Northwestern 2019) and the Inte rnational Scholars lecture at Conference in Charleston, South Carolina (September University, Chicago, IL, (April 2018) and the Roswell

6 www.cornellpathology.com Section Editor for the Jou rnal of American Society Journal of Clinical Pathology, Seminars in Diagnostic Keynotes of Cytopathology. Pathology, and The American Jou rnal of Surgical Pathology. She serves as Associate Editor of Archives continued from page 6 G Dr. Lars Westblade had a number of regional of Pathology and Lab oratory Medicine, Senior and n ational speaking engagements including: Asso ciate Editor of Mode rn Pathology, and is an Lab oratory Literature Review, First Coast ID/ ab stract reviewer for the College of American CM Symposium, February 2nd 2019, in Ponte Pathol ogists. Dr. Yantiss con tinues to serve on the Park Cancer Center, Buffalo, NY (February 2019), Vedra Beach, FL; A Clinical Microbiologist’s Anti- Education Committee and is Chair of the Abstract where he presented “N-Myc Drives Lineage Plas ticity mi crobial Susceptibility Journey: not the Path Review and Assignment Committee of the United in Castration-Re sistant Prostate Cancer.” He was of Least Resist ance, Wadsworth Center, March States and Canadian Acad emy of Pathology. She also an invited speaker at the Vancouver Prostate 15th 2019, in Albany, NY; Microbiology for the also serves on the American Board of Pathology Centre, University of British Columbia, Canada Masses, Academy of Clinical Laboratory Physicians Test Development and Advisory Com mittee for (July 2018) and the Mainfranken Comprehensive and Scientists Annual Meeting, May 30th 2019; Anatomic Pathology. Dr. Yantiss is the President- Cancer Center, Graduate School of Life Science, What you Should be Doing and What’s to Come, Elect of the Arthur Purdy Stout Society of Surgical University of Wurzburg, Ger many, (November 2019) Michigan Department of Health and Human Services Pathologists. where he presented “N-Myc-Me diated Epigenetic CRE Surv eillance and Prevention C onference, June n Reprogramming Drives Lineage Plasticity in Ad - 11th 2019, in Plymouth, MI; Integrating Rapid Diag - vanced Prostate Cancer.” nostics into Antimicrobial Stewardship: Microbiology G Dr. Teresa Sanchez was invited to MD and Stewardship Synergies, ASM Microbe 2019, Ander son C ancer Center, Houston, TX, as Visiting June 20th 2019, in San Francisco, CA; Guess the Newly Awarded Pro fessor to speak at the 2018 Pediatrics Research Re sistance Mechanism, ASM Microbe 2019, June Pathology Grants Seminar Series (Depart ment of Pediatrics and 21st 2019, in San Francisco, CA; Literature Review, Mo lec ular and Cel lular Oncology) (March 2018). In fectious Dis eases Diagnostics, ASM Microbe “Sphingolipid Signaling in Endothelial Dysfunction.” 2019, June 22nd 2019; S an Francisco, CA; Case Studies, SCASM 83rd Annual Meeting, Oc tober t NIH Support for Scientific She presented her work at the 2018 Gordon Research Conferences (R13) 26th 2019, in San Diego, CA; and Wonderful World Conference, Neurobiology of Brain Disorders, Barcelona, Title: The 22nd international conference on of Staphylococci!, 2019 SEACM Annual Meeting, Spain (July 2018). The title of her talk was “Neurovas - Kaposi's sarcoma- associated herpes virus and cular Sphingosine-1-P hosphate Signaling in Health No vember 16th 2019, Myrtle Beach, SC. related agents and Dis ease: Mechanist ic Insights and Therap eut ic G Dr. Jenny Yang is the recipient of the Kellen Principal Investigator: Ethel Cesarman, MD, PhD Opportunities.” Dr. Sanchez was invited to speak at Junior Faculty Award, selected among her peers Period of Support: 04/09/2019 – 03/31/2020 Total Direct Costs: $8,000 the 2019 International Cerebral Vascular Biology across the medical college. This is a notable Conference, Miami, FL. The title of her talk was “Endo- achieve ment. Congratulations! t Inter-campus Seed Grant thelial Sphingolipid Signaling in Stroke: Mechanistic Title: Disruption of protein synthesis by G Insights and Therapeutic Potential” (June 2019). Dr. Rhonda Yantiss had a number of national cytoplasmic inclusions of RNA-binding proteins and i nte rnational speaking engagements, including drives cytotoxicity and neurodegeneration in G Dr. Momin Siddiqui serves as the Chief of presentations at Scientific Symposiums in Maui, ALS/FTD Pa pani colaou Cytology Laboratory at Weill Cornell Hawaii, the 3 0th European Congress of Pathology in Principal Investigator: Jessica Tyler, PhD Medicine. 2019 has been a busy year for Dr. Siddiqui. Bilbao, Spain, and Diagnostic Pathology Updates of the & Slu Sylvia Lee, PhD (Cornell, Ithaca) He had a number of national and inte rnational United States and Canadian Academy of Pathology in Period of Support: 07/01/2019 – 06/30/2020 speak ing presentations. He organized and moder - Napa, California. She was a visiting lecturer in the Total Direct Costs: $75,000 ated the American Society of Cytopathology Sur gical Pathology f or the Practicing Pathologist t National Institutes of Health Research Com panion Meeting titled “Serous Cavity Fluids: Course of Harvard Medical School in Fo rt Myers, Grant (R01) Mo mentum, Molecules, Markers …and More!!!” at Florida, the 6th Princeton Integ rated Pathology Title: Role of novel onco-histone mutations the USCAP 2019 meeting. T his was followed by Sym posium in Plainsboro, New Jersey, and the 26th in B-cell malignancies chairing sessions and participating as faculty at the An nual Seminar in Pathology of Allegheny Health Principal Investigator: Ethel Cesarman, MD, PhD & Charles David Allis, PhD (Rockefeller) In ternational Congress of Cytology in Sydney, Net work, Pittsburgh, Pennsylvania. She was t he Davey Period of Support: 08/01/2019 – 07/31/2024 Aus tralia in May 2019. He was an invited speaker Lecturer for Discovery, Research, Innovation, and Total Direct Costs: $630,707 at the Siriraj-Johns Hopkins Cy topathology Course Ed ucation at the University of Alberta, Edmonton, in Bangkok, Thailand in July 2019 and the 2019 Canada, and presented in two interactive courses at t HHV-6 Foundation Grant Croatian Society of Clinical Cytology Meeting in the United States and Canadian Academy of Pathology Title: HHV-6 in the lymphoma microenvironment Principal Investigators: Genevieve Crane, MD, PhD Za greb, Croatia in September 2019. He also moder - Interactive Center in Palm Springs, California. She & Ethel Cesarman, MD, PhD ated sessions and was an invited fac ulty at the 2019 di rected the Tutorial on Pathology of the GI Tract, Period of Support: 08/06/2019 – 08/05/2020 American Society of Clinical Pathol ogy Annual Pancreas, a nd Liver for the United States and Total Direct Costs: $9,309 Meeting in Phoenix, AZ and the American Society of Canadian Academy of Pathol ogy in San Sebastian, Cyto-pathol ogy Annual Scientific Meeting in Salt Spain and lectured at the 24th Congress of the t NIH High Priority, Short-Te rm Project Award (R56) Lake City, UT. He organized and di rected the Chi nese Society of Pathology in Chengdu, China on Title: Mechanisms underlying integrated stress Pa panicolaou and Frost 2019 Cytopathology Tuto - behalf of the United States and Canadian Academy response induced inflammation rial in New York, NY, in August 2019. Dr Siddiqui of Pathology. Dr. Yantiss continues to serve as an ad Principal Investigator: Jihye Paik, PhD con tinues to serve on the editorial boards of Cancer hoc reviewer for fifteen journals, and is an editorial Period of Support: 09/01/2019 – 08/31/2020 Cytopathol ogy, Diagnostic Cytopathology, Acta board member of the Archives of Pathology and Total Direct Costs: $250,000 Cy tologica and Cytojournal, and was appointed a Laboratory Medicine, Modern Pathol ogy, American continued on page 8

7 t JumpStart Research Career Development Program t National Institutes of Health Research Title: The stem cell basis of the bifurcation between Grant (R01) Pathology Grants adipogenic versus osteogenic lineages Title: Cooption of the DNA damage response continued from page 7 Principal Investigator: Shawon Debnath, PhD for epigenetic regulation of inflammation (Research Associate, Matthew Greenblatt Lab) Principal Investigator: Steven Josefowicz, PhD Period of Support: 07/01/2019-06/30/2022 Period of Support: 12/01/2019-11/30/2024 Total Direct Costs: $300,000 Total Direct Costs: $1,250,000 t Pershing Square Sohn Cancer Research Alliance Title: Targeting skeletal stem cells to treat t The Daedalus Fund for Innovation National Institutes of Health Research tumor-induced osteolysis t Title: Development and in vitro validation of novel Grant (R01) Principal Investigator: Matthew Greenblatt, MD, PhD antibody therapeutics for vascular disorders Title: Endothelial sphingolipid synthesis and Period of Support: 07/01/2019-06/30/2022 Principal Investigator: Teresa Sanchez, PhD tissue inflammatory response Total Direct Costs: $545,454 Period of Support: 04/01/2019-03/31/2020 Principal Investigator: Annarita DiLorenzo, PhD Total Direct Costs: $100,000 t MSK Lymphoma SPORE Career Enhancement Period of Support: 12/10/2019-11/30/2023 Program t National Institutes of Health (P01 Subaward) Total Direct Costs: $1,078,000 Title: Targeting metabolic vulnerabilities in Title: The impact of changes in chromatin The Medical Centre Insurance Company primary effusion lymphoma using the novel architecture on cancer phenotypes and tumor t (MCIC) Vermont nucleoside analog (6-ETI) progression Title: Enhancing pathology accuracy through Principal Investigator: Jouliana Sadek, PhD Principal Investigator: Giorgio Inghirami, MD artificial intelligence slide review (Instructor, Ethel Cesarman Lab) Period of Support: 06/01/2019-05/31/2020 Principal Investigator: Alain Borczuk, MD Period of Support: 08/01/2019-07/31/2020 Total Direct Costs: $121,782 Period of Support: 03/01/2020-12/31/2020 Total Direct Costs: $50,000 t US Department of Defense (Subaward) Total Direct Costs: $20,000 t National Institutes of Health (R01) Title: Molecular and clinical correlates with Title: Defining molecular determinants of prostate-specific membrane antigen (PSMA)- t Lymphoma Research Foundation lineage plasticity a s a mechanism of treatment targeted radionuclide therapy Fellowship Grant resistance in prostate cancer Principal Investigator: Francesca Khani, MD Title: Signaling to chromatin pathways in Principal Investigator: David S. Rickman, PhD Period of Support: 07/01/2019-06/30/2020 regulation of germinal center B cell Period of Support: 08/01/2019-07/31/2024 Total Direct Costs: $10,331 differentiation and lymphoma Total Direct Costs: $1,443,165 Principal Investigator: Alexia Martinez De Paz t WCM SPORE Career Enhancement Award (postdoc in Steven Josefowicz Lab) t National Institutes of Health Title: Prostate cancers with MAPK oncogenic Period of Support: 03/01/2020-02/28/2022 Title: Recipient epidemiology and donor driver mutations: characterizations of a Total Direct Costs: $105,000 n evaluation study IV-pediatric (REDS-IV-P)- potentially novel and targetable molecular domestic hubs- Phase 1 subclass associated with aggressive behavior Principal Investigator: Melissa Cushing, MD Principal Investigator: Francesca Khani, MD Period of Support: 04/01/2019-03/31/2020 Period of Support: 08/01/2019-07/31/2020 Total Direct Costs: $35,826 Total Direct Costs: $50,000

Congratulations Dr. Rhonda K. Yantiss PRESS RELEASE For Immediate Release Dear Dr. Yantiss,

The American Board of Pathology Announces the Appointment of Rhonda K. Yantiss, It is my honor to inform you that you have been Professor of Pathology and Laboratory Medi cine at W eill Cornell Medical College to the selected to receive the 2019-2020 Honorary ! Test De velopment and Advisory Committee for Gastrointestinal, Liver, and Pancreatic pathology . Fel lowship Award presented by the Weill Cornell ! TAM! PA, Fl!a., ( January, 9, 202 0)- The American Board of Pathology (ABPath) is pleased to announce Medical College Alumni Association. Each year th! e appoi!ntmen!t of Rhonda K. Yantiss to the ABPath’s Test Development and Advisory Committee (TDAC) the Alumni Association presents two Honorary for G!astroint!estina! l,! Liver, an! d Pancre! ati!c patholog!y !for 202! 0!. The T!DACs are responsible for developing Fellowship Awards to individuals who did not and re!vie! wing th!e A!BPath ce !rtificati!on! exa!m que! stions! that a! ss! es!s an! d certify a physician’s education, re ceive their MD or PhD degree from the ! ! ! ! ! ! ! ! ! ! knowledge, experience, and skills in order to provide high quality care in the pathology profession. Med ical College and who, by their scholarship, ! ! ) ) ! ! ! ! ! ! ! ! ! ! To be ! ap!pointed to! a! TDAC! m! ean!s !a p!hysicia!n is! an estab!lish!ed subject matter expert in their sub- dedication and leadership have greatly spe c!ialty field! and !is !current on th!e lat!est! advanc!es in the) c!ontin! ua!lly evolving field of pathology and en hanced and en riched the life of the Medical pat!ien!t care. T!DA! C comm! itte! e mem! be!rs de!velop and! rev!iew exa! mination questions for statistical College, its fac ulty, and its students. ! ! ! ! ! ! ! ! ! ! ! ! ! ! per f!orm! ance! an!d !rel!evance !to curre!!nt practice. They contribute to the validity of examinations by The award will be presented during Reunion / d! e !terminin!g !th! e co! nten!t !and dis!tr!ibu! tion of i!tems o! n exa! mina! ti!ons! (exam blueprints). The TDACs also advise t!he A! BP! a!th on !iss! ue!s in t! heir su!bs! pe!cialty are! a of e!xpe!rti!se. on Friday, September 11, 2020 at 9:00 a.m. ! ! ! ! ! ! ! ! ! ! ! Again, my congratulations. “As T!DA!C mem!bers, thes! e p! hysicia!ns! play! a critic! al r!ole in th! e! de!velopment of the exams and are en tr!us! ted with m! a!intaining t! he! integr!ity !of the bo!ar!d-ce!rti!fied design! ation. The appointment to a TDAC Best, ind!icates the!!/8'!/D0F.!*-.#!*(E).'!+8'!0;2*+8!#:!)..@'.!):!+8')$!.@K.?'9)*-+>!*$'*!#

q Dr. Matthew Canver (PGY-2, CP-PSTP).

t “RCT FULLFACE.”

pThe digital image contest had 13-entries and the win ner was Dr. Danielle D’Ambrosio q Best scientific poster presentation of 18-posters (PGY-4, AP/CP) for her photo (right) “RCT FULLFACE.” pre sented went to Dr. Miguel Cantu (PGY-4, AP/CP).

All winners were awarded with gi ft certificates. Con gratulations to all on your excellent presentation s and pa rticipation. p Housesta ff and Residency Program Leadership at the annual holiday party held at the Metropolitan Club.

9 Visit our Residency Program Welcome Welcome on Facebook www.facebook.com/ New Residents New Fellows cornellpatholresidencypgm

Paul Dylan Barone, MD Yahya Al-Ghamdi, MBBS Mihn Yen Mays, MD Paul completed his MD from Weill Hematopathology Hematopathology Cornell Medicine. His undergrad - Yahya graduated medical school Mihn graduated from Creighton uate degree is in Cell and Molec - in 2001 from Umm Al-Qura University School of Medicine in ular Biology from the University Uni versity Faculty of Medicine 2015. She completed her AP/ of Binghamton. Paul has been from Saudi Arabia. He completed CP residency from Creighton around the department for a few his AP/CP residency from Rush Uni versity Medical Center in years working with the pathology University in Chicago, IL. Omaha, Nebraska. student interest group, coming to conferences, and writing iBooks in support of Hussein Alnajar, MBChB Patrick McIntire, MD medical student pathology education here at Weill Genitourinary Fellowship Breast Pathology Cornell. Paul is an incoming AP/CP resident. Hussein completed his medical Patrick was a graduating resident school in Iraq at Al-Mustansyria from our AP program here at Shaham Beg, MBBS University in 2010. He then com - Weill Cornell Medicine/NewYork- Shaham completed his medical pleted his AP/CP residency from Presbyterian Hospital in 2018. He education and a residency in Rush University in Chicago, IL. recently completed his first Pathology at the Jawaharlal Hussein is currently completing fel lowship in Cytopathology at Nehru Medical College in Aligarh his Surgical Pathology fellowship Loyla University. in India and has been a practicing at North Shore University Health System. pathologist, prior to joining the Ami Patel, MD Englander Institute of Precision Kenrry Chiu, MD Cytopathology Medicine at Weill Cornell Med- Gastrointestinal Pathology Ami completed her residency icine as the previous Research Fellow. Shaham is Kenrry joins us from Canada in AP/CP program Weill Cornell an incoming AP/CP res ident. where he completed his Medical Medicine/NewYork-Presbyterian school at McGill University in Hospital and will be staying on Diana Rose Berman, MD 2014. He moved to Vancouver to as a Cytopathology Fellow. Diana completed her MD from complete his AP residency at the the Howard University College University of British Columbia. of Medicine, where she was Alexandra Budhai, MD AOA. Her undergraduate degree Erika Hissong, MD Transfusion Medicine is in Bioengineering from the Molecular Genetics Pathology Alexandra obtained her MD Uni versity of California, LA. Diana Erika was a resident from our AP/ from Ross University School of is an incoming AP/CP resident. CP program here at Weill Cornell Medicine in 2015 and completed Medicine/NewYork-Pres byterian her Anatomic and Clinical Alicia Veonia Dillard, MD Hospital in 2018. She completed Pathol ogy Residency training in Alicia completed her MD from the her GI fellowship here as well 2019 at Westchester Medical Howard University College of be fore moving on to her Molecular Cente r/New York Medical Medicine with an aca demic Genetics fellowship. College. She joins our department as the scholarship. Her undergraduate Trans fusion Medi cine Fellow, where she will degree is in Neuroscience from com plete the trans fusion service portion of her Brown University. Alicia is an fellowship from July-December 2019. n in coming AP/CP resi dent. Depa rtment of Pathology and Laboratory Medicine Je ffrey Michael Kubiak, MD, PhD Leadership Appointments: Promotions: Jeffrey completed his MD, PhD Melissa Cushing, MD Nina Schatz-Siemers, DO Vice Chair for Laboratory Medicine Assistant Professor of Pathology and from the Perelman School of Laboratory Medicine Medicine at the University of Ethel Cesarman, MD, PhD Pennsylvania. His undergraduate Vice Chair for Education Theresa Scognamiglio, MD Lars Westblade, PhD Associate Professor of Clinical Pathology and degree is in Biology from George - Laboratory Medicine town University in DC and his Director of Clinical Microbiology David Pisapia, MD PhD is in Cell and Molecular Biology- Microbiology, Associate Professor of Pathology and Virology, and Parasitology. Jeff is an in coming Laboratory Medicine AP/CP resident.

10 www.cornellpathology.com of liver metastasis. Methods Mol Biol 1882:309-320, 2019. 0713.2019. doi: 10.1158/1055-9965. EPI- 19-0713, 2019. Buicko J, Finnerty BM, Zhang T, Kim B, Fahey TJ 3rd, Du Faculty YN : Insights into the biology and treatment strategies of Hamid AA, Gray KP, Huang Y, Bowden M, pancreatic neuroendocrine tumors. Ann Pancreatic Ca Pomerantz M, Loda M , Sweeney CJ: Loss Publications 2:12. 2019. of PTEN expression detected by fluores - cence immunohistochemistry predicts lethal in 2019 Goren L, Zhang G, Kaushik S, Breslin PAS, Du YN , Foster prostate cancer in men treated with prostatectomy. Eur Urol DA: (-)-Oleocanthal and (-)-oleocanthal-rich olive oils in - Oncol 2:475-482, 2019. Sung DK, Baergen RN : Focal chorangiosis: Does it have duce lysosomal membrane permeabilization in cancer clinical and pathological significance? Pediatr Develop cells. PLoS One PMID: 31412041, 2019. Beltran H, Hruszkewycz A, Scher HI, Hildesheim J, Isaacs Pathol 22:406-40, 2019. 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Solomon JP , Linkov I, Rosado A, Mullaney K, Rosen EY, Frosina D, Jungbluth AA, Zehir A, Benayed R, Drilon A, Volume 26 • February 2020 Lee RS, Zhang L, Berger A, Lawrence MG, Song J, Niranjan Hyman DM, Ladanyi M, Sireci AN, Hechtman JF: NTRK B, Davies RG, Lister NL, Sandhu SK, Rubin MA, Risbridger fu sion detection across multiple assays and 33,997 cases: Editor Massimo Loda, MD GP, Taylor RA, Rickman DS , et al: Characterization of the diagnostic implications and pitfalls. Mod Pathol Aug 2, Co-Editor David P. Hajjar, PhD ERG-regulated kinome in prostate cancer identifies TNIK 2019. as a potential therapeutic target. Neoplasia 21:389-400, Managing Editor Gina L. Imperato, MPA 2019. Xing D, Liu Y, Park HJ, Baek I, Tran H, Cheang G, Novo J, Dillon J, Matoso A, Farmer E, Cheng MA, Tsai YC, Lombardo Design JBRH Advertising & Design, Inc. McIntire PJ, Snow JT, Elsoukkary SS, Soong L, Robinson BD, K, Conner MG, Vang R, Hung CF, Wu TC, Song W : Recurrent If you have any comments or questions, Siddiqui MT : Digital image analysis supports a nuclear- genetic alterations and biomarker expression in primary to-cytoplasmic ratio cut-off value below 0.7 for positive for and metastatic squamous cell carcinomas of the vulva. please contact: high-grade urothelial carcinoma and suspicious for high- Hum Pathol 92:67-80, 2019. Managing Editor, Gina L. Imperat o grade urothelial carcinoma in urine cytology specimens. tel: (212) 746-6464 Ca Cytopathol 127120-124, 2019. Goel R, Vasovic LV, Westblade LF , Harris R, D’Ambrosio D, Foxwell E, Lo D, Hsu YM , Jenkins SG, Cushing MM : The email: [email protected] Robinson BD , Vlachostergios P, Bhinder B, Liu W, Li K, power of a trained eye: First reported fatal transfusion-

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