The David Rockefeller Graduate Program Non-Departmental Campus Promotes In- 2Alumni Have Teractions Between Won the Nobel Fields Prize
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Spring 2004 (PDF)
SPRING 2004 At www.hunter.cuny.edu In this Issue: The Sciences at Hunter: Happenings 2 at Hunter On the Leading Edge The President’s 3 Perspective unter College is one of the most outstanding science institutions in the nation, thanks Hunter Welcomes 3 to its stellar faculty. Hunter’s science professors not only initiate and conduct 49 New Faculty Hgroundbreaking research, but also teach and mentor their students with extraordinary dedication and brilliance—and reflect and foster the diversity that is one of Four Extraordinary 4 Hunter’s greatest assets. New Grads Because of the abilities and determination of both faculty and students—and also because of the programs Hunter offers to support science students, especially those from minorities Track Stars 5 underrepresented in the sciences—Hunter’s science graduates go on to prestigious doctoral Leap Over Cultural Divide programs and from there to promising careers in both academia and industry. These aspiring scientists are fully prepared for top-level careers, for their Hunter Top Scientists 6 education has taken place in a first-rate, highly productive scientific environment. Hunter’s researchers carry out significant, cutting-edge investigations; major professional journals The many labs and Future found throughout Scientists publish articles about their discoveries and experiments; and their projects receive ever- the Hunter cam- increasing grants from private sources as well as major government bodies. puses provide a vibrant research Introducing 8 In addition to training research scientists who will expand the frontiers of knowledge, environment for College Hunter is also preparing the men and women who will enter such professions as nursing, undergraduate Science to and graduate medical technology, and other science-based fields that play an essential role in maintaining science students, High Schoolers individual and national well-being. -
Meet the Faculty Candidates
MEET THE FACULTY CANDIDATES Candidates are displayed in alphabetically by last name. Prospective employers are invited to attend and while no event pre-registration is required however they must be registered for the BMES 2018 Annual Meeting. A business card will be required to enter the event. COMPLETE DETAILED CANDIDATE INFORMATION AVAILABLE AT www.bmes.org/faculty. Specialty - Biomaterials Alessia Battigelli Woo-Sik Jang Sejin Son John Clegg Patrick Jurney Young Hye Song R. Cornelison Kevin McHugh Ryan Stowers Yonghui Ding Yifeng Peng Varadraj Vernekar Victor Hernandez-Gordillo Shantanu Pradhan Scott Wilson Marian Hettiaratchi Eiji Saito Yaoying Wu Era Jain Andrew Shoffstall Specialty - Biomechanics Adam Abraham Vince Fiore Panagiotis Mistriotis Edward Bonnevie Zeinab Hajjarian Simone Rossi Alexander Caulk Xiao Hu Alireza Yazdani Venkat Keshav Chivukula Heidi Kloefkorn Rana Zakerzadeh Jacopo Ferruzzi Yizeng Li Specialty - Biomedical Imaging Mahdi Bayat Chong Huang Katheryne Wilson Zhichao Fan Jingfei Liu Kihwan Han Alexandra Walsh Specialty - BioMEMS Jaehwan Jung Aniruddh Sarkar Mengxi Wu Specialty - Cardiovascular Engineering Reza Avaz Kristin French Zhenglun (Alan) Wei Specialty - Cellular Engineering Annie Bowles Kate Galloway Kuei-Chun Wang Alexander Buffone Laurel Hind Mahsa Dabagh Matthew Kutys See other side for more candidates Specialty - Device Engineering (Microfluidics, Electronics, Machine-Body interface) Taslim Al-Hilal Brian Johnson David Myers Jungil Choi Tae Jin Kim Max Villa Haishui Huang Jiannan Li Ying Wang Specialty -
Elaine Fuchs
Women in Cell Science 4877 Elaine Fuchs FMW: How has your research career impacted on your personal life and vice Elaine Fuchs was born in the United versa? States and raised just outside Chicago. In 1972 she graduated with EF: My father was a geochemist who a B.S. and highest distinction in specialized in meteorites at Argonne the Chemical Sciences from the National Laboratories. My aunt, who University of Illinois. Her lived in the house next door, was a undergraduate thesis research in biologist at Argonne, and an ardent physical chemistry focused on the feminist. My sister, four years my senior, electrodiffusion of nickel through is now a neuroscientist. My mother is a quartz. She moved from Illinois to housewife, who loves gardening and Princeton University to study for her cooking and used to play piano and paint PhD in Biochemistry, investigating in oils. Growing up in such a family, and changes in bacterial cell walls during with farm fields, creeks and ponds in the sporulation in Bacillus megaterium. near vicinity, I developed a deep interest Elaine Fuchs in her lab in 1980. In 1977, she joined Howard Green, in science that has carried me through then at Massachusetts Institute my professional life. of Technology (MIT), for her If I think back to the family influences during Vietnam War protests. Although postdoctoral studies. There, she that shaped my choice of career, I my near perfect performances on tough focused on elucidating the remember that my Dad strongly physics and chemistry exams may have mechanisms underlying the balance advocated my being an elementary turned a few heads, I don’t feel that it between growth and differentiation in school teacher. -
Looking at Earth: an Astronaut's Journey Induction Ceremony 2017
american academy of arts & sciences winter 2018 www.amacad.org Bulletin vol. lxxi, no. 2 Induction Ceremony 2017 Class Speakers: Jane Mayer, Ursula Burns, James P. Allison, Heather K. Gerken, and Gerald Chan Annual David M. Rubenstein Lecture Looking at Earth: An Astronaut’s Journey David M. Rubenstein and Kathryn D. Sullivan ALSO: How Are Humans Different from Other Great Apes?–Ajit Varki, Pascal Gagneux, and Fred H. Gage Advancing Higher Education in America–Monica Lozano, Robert J. Birgeneau, Bob Jacobsen, and Michael S. McPherson Redistricting and Representation–Patti B. Saris, Gary King, Jamal Greene, and Moon Duchin noteworthy Select Prizes and Andrea Bertozzi (University of James R. Downing (St. Jude Chil- Barbara Grosz (Harvard Univer- California, Los Angeles) was se- dren’s Research Hospital) was sity) is the recipient of the Life- Awards to Members lected as a 2017 Simons Investi- awarded the 2017 E. Donnall time Achievement Award of the gator by the Simons Foundation. Thomas Lecture and Prize by the Association for Computational American Society of Hematology. Linguistics. Nobel Prize in Chemistry, Clara D. Bloomfield (Ohio State 2017 University) is the recipient of the Carol Dweck (Stanford Univer- Christopher Hacon (University 2017 Robert A. Kyle Award for sity) was awarded the inaugural of Utah) was awarded the Break- Joachim Frank (Columbia Univer- Outstanding Clinician-Scientist, Yidan Prize. through Prize in Mathematics. sity) presented by the Mayo Clinic Di- vision of Hematology. Felton Earls (Harvard Univer- Naomi Halas (Rice University) sity) is the recipient of the 2018 was awarded the 2018 Julius Ed- Nobel Prize in Economic Emmanuel J. -
2011 Annual Report
Memorial Sloan-Kettering Cancer Center 2011 Annual Report 10 steps closer 10 steps closer Letter from the Chairman and the President 1 1 | First effective treatments for advanced melanoma 5 2 Genomic analysis offers clues to most common | type of ovarian cancer 7 3 Breast cancer surgery: practice-changing | findings for some patients 9 4 New drugs offer survival benefit for men | with metastatic prostate cancer 11 5 | Insights into DNA damage and repair 13 6 Novel stem cell technique shows promise | in treating disease 15 7 Combination therapy may prevent spread | of nasopharyngeal tumors 17 8 Algorithm can predict shape of proteins, | speeding basic cancer research 19 9 Two of 2011’s top five advances in cancer | research led by MSKCC physician-scientists 21 10 | The Josie Robertson Surgery Center 23 The Campaign for Memorial Sloan-Kettering 25 Statistical Profile 27 Financial Summary 29 Boards of Overseers and Managers 31 www.mskcc.org/annualreport Letter from the Chairman and the President The year 2011 was a strong one at Memorial Sloan-Kettering. We continued to lead across “Our success as an institution is due in the spectrum of patient care, research, and training, and laid the groundwork for important progress in the years ahead. great measure to our remarkable staff… We want to begin by saying that our success as an institution is due in great measure to our remarkable staff. On a daily basis, we are inspired by their dedication and compassion, and We are inspired by their dedication Douglas A. Warner III are grateful for the work they do in the service of our patients and our mission. -
Faster Growth with Shorter Antigens Explains a VSG Hierarchy During African Trypanosome Infections: a Feint Attack by Parasites
bioRxiv preprint doi: https://doi.org/10.1101/131029; this version posted April 26, 2017. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Faster growth with shorter antigens explains a VSG hierarchy during African trypanosome infections: a feint attack by parasites Dianbo Liu1, Luca Albergante1,2, David Horn1,*, Timothy Newman1,* 1School of Life Sciences, University of Dundee, Dundee, UK 2U900, Institut Curie, 75005, France *These authors contributed equally Correspondence to [email protected] and [email protected] Abstract The parasitic African trypanosome, Trypanosoma brucei, evades the adaptive host immune response by a process of antigenic variation that involves the clonal switching of variant surface glycoproteins (VSGs). The VSGs that periodically come to dominate in vivo display a hierarchy, but how this hierarchy arises is not well-understood. Combining publicly available genetic data with mathematical modelling, we report a VSG-length-dependent hierarchical timing of clonal VSG dominance in a mouse model, revealing an inverse correlation between VSG length and trypanosome growth-rate. Our analysis indicates that, among parasites switching to new VSGs, those expressing shorter VSGs preferentially accumulate to a detectable level that is sufficient to trigger an effective immune response. Subsequent elimination of faster-growing parasites then allows slower parasites with longer VSGs to accumulate. This interaction between the host and parasite is able by itself to explain the temporal distribution of VSGs observed in vivo. -
Schedule of C Ourses
2017–2018 Schedule of Courses Schedule The David Rockefeller Graduate Program offers a Required reading: Molecular Biology of the Cell by Bruce Alberts et al.; Molecular Cell Biology by James E. Darnell et al. selection of courses, many of which students can Recommended reading: Basic Histology by Luiz Carlos Junqueira choose based on their interests and area of thesis et al. research. Organized by Rockefeller faculty, and taught Method of evaluation: Attendance, participation in the discussions, by scientists at the top of their fields, both from within student presentations, and a final oral exam and outside of the university, these courses are designed to provide a stimulating and dynamic curriculum that Cell Cycle Control students can tailor to fit their personal goals, in FREDERICK R. CROSS and HIRONORI FUNABIKI consultation with the dean of graduate studies. This seminar explores the current understanding of eukaryotic cell cycle control. Topics include the construction of a biochemical oscillator and overall structure of cell cycle control; positive and Biochemical and Biophysical Methods negative control of DNA replication; spindle morphogenesis and function; chromosome cohesion control; surveillance mechanisms SETH A. DARST and MICHAEL P. ROUT (checkpoints) monitoring spindle and DNA integrity; and control of This course presents the fundamental principles of biochemistry proliferation (start/restriction point control). The seminar relies heavily and biophysics, with an emphasis on methodologies. It addresses on studies in model organisms, but the emphasis throughout will be issues of protein and nucleic acid structure and the forces that on aspects of cell cycle control conserved among eukaryotes. underlie stability and govern the formation of specific three- Class length and frequency: 2.5-hour lecture and discussion, dimensional structures. -
Resubmission JBC Frescas and De Lange
Cell Biology: Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection David Frescas and Titia de Lange J. Biol. Chem. 2014, 289:24180-24187. doi: 10.1074/jbc.M114.592592 originally published online July 23, 2014 Downloaded from Access the most updated version of this article at doi: 10.1074/jbc.M114.592592 http://www.jbc.org/ Find articles, minireviews, Reflections and Classics on similar topics on the JBC Affinity Sites. Alerts: • When this article is cited • When a correction for this article is posted at Rockefeller University Library on August 31, 2014 Click here to choose from all of JBC's e-mail alerts This article cites 29 references, 13 of which can be accessed free at http://www.jbc.org/content/289/35/24180.full.html#ref-list-1 THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 289, NO. 35, pp. 24180–24187, August 29, 2014 © 2014 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A. Binding of TPP1 Protein to TIN2 Protein Is Required for POT1a,b Protein-mediated Telomere Protection* Received for publication, June 30, 2014, and in revised form, July 22, 2014 Published, JBC Papers in Press, July 23, 2014, DOI 10.1074/jbc.M114.592592 David Frescas and Titia de Lange1 From the Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, New York 10065 Background: Chromosome ends require the TPP1/POT1 heterodimers for protection. Results: A TIN2 mutant that fails to bind TPP1 resulted in phenotypes associated with TPP1/POT1 deletion. -
Analysis of Activation Induced Cytidine Deaminase Using Atomic Force Microscopy by C David J
Analysis of Activation Induced Cytidine Deaminase using Atomic Force Microscopy by c David J. G. Gale A dissertation submitted to the School of Graduate Studies in partial fulfillment of the requirements for the degree of Master of Science Department of Chemistry Memorial University of Newfoundland April 2021 St. John’s Newfoundland Abstract Activation induced cytidine deaminase (AID) plays a large part within the pathway of immunoresponse. It does so by inserting mutations, during DNA replication, in B cells (immune system cells). This results in a more diverse set of antibodies in each subsequent generation. However, mutations that cause infinite replication with no cellular apoptosis, can lead to cancer. AID has been implicated in cancers which appear independent of the expected environmental causes, such as smoking or UV exposure. The method for AID mutations involves binding to single-strand DNA. Using Atomic Force Microscopy (AFM) we obtained both the geometry or topology, as well as the nanomechanical information about this mutation process and AID. In this thesis, I present the first AFM images of AID, showing direct structural information about the protein. Although the measurements are done in vitro, physiological con- ditions have been approximated in order to get an accurate analysis of the protein system. To allow imaging in buffer, suitable substrates were tested and identified which would bind the protein sufficiently in this high ionic strength environment. Optimized plating and scan conditions for AID in both wet and dry conditions are described, which allow high resolution imaging to be performed that is not often seen in biological systems. Through the many scans and procedural changes it was estab- lished that although difficult it is possible to gain an image of AID through the use ii of AFM. -
Mary Elizabeth Hatten
Mary Elizabeth Hatten BORN: Richmond, Virginia February 1, 1950 EDUCATION: Hollins College, Roanoke, VA, AB (1971) Princeton University, Princeton, NJ, PhD (1975) Harvard Medical School, Boston, MA, Postdoctoral (1978) APPOINTMENTS: Assistant Professor of Pharmacology, New York University School of Medicine (1978–1982) Associate Professor of Pharmacology (with tenure), New York University School of Medicine (1982–1986) Associate Professor of Pathology in the Center for Neurobiology and Behavior College of Physicians and Surgeons of Columbia University (1986–1988) Professor of Pathology in the Center for Neurobiology and Behavior College of Physicians and Surgeons of Columbia University (1988–1992) Professor and Head of the Laboratory of Developmental Neurobiology, The Rockefeller University (1992–2000) Frederick P. Rose Professor and Head of the Laboratory of Developmental Neurobiology, The Rockefeller University (2000–present) HONORS AND AWARDS (SELECTED): Westinghouse National Science Talent Search Award Finalist (1967) Research Fellow of the Alfred P. Sloan Foundation (1983–1985) Pew Neuroscience Award (1988–1992) McKnight Neuroscience Development Award (1991–1993) Javits Neuroscience Investigator Award (1991–1998) National Science Foundation Faculty Award for Women Scientists and Engineers (1991–1996) Weill Award, American Association of Neuropathology (1996) Ph.D., Hollins College, honoris causa (1998) Fellow, American Association for the Advancement of Science (2002) Distinguished Alumna Award, Hollins University (2011) Cowan-Cajal Award for Developmental Neuroscience (2015) Elected to National Academy of Sciences, USA (2017) Ralph J. Gerard Prize in Neuroscience, Society for Neuroscience (2017) Mary E. Hatten has used the mouse cerebellar cortex as a model to study molecular mechanisms of central nervous system (CNS) cortical neurogenesis and migration. She pioneered live imaging methods that proved that CNS neurons migrate on glial fibers and revealed a specific, conserved mode of CNS neuronal migration along glial fibers in different cortical regions. -
Schedule of C Ourses
2020–2021 Schedule of Courses Schedule The David Rockefeller Graduate Program offers a multiple sclerosis); perception, cognition, and memory (autism, schizophrenia, and Alzheimer’s disease); consciousness (coma selection of courses, many of which students can and persistent vegetative state); mood (depression and anxiety); choose based on their interests and area of thesis motivation (addiction); sensation (pain); motor control (Parkinson’s research. Organized by Rockefeller faculty, and taught disease and ataxia); and trauma (brain or spinal cord injury and stroke). by scientists at the top of their fields, both from within Class length and frequency: Two-hour session, once weekly and outside of the university, these courses provide a Method of evaluation: Attendance, participation in the discussions, stimulating and dynamic curriculum that students can student presentations, and a final speculative paper relating a tailor to fit their personal goals, in consultation with disordered trait to a specific brain circuit the dean of graduate studies. Cell Biology SANFORD M. SIMON and SHAI SHAHAM Biochemical and Biophysical Methods, I & II This advanced course covering major topics in modern cell biology is GREGORY M. ALUSHIN, SETH A. DARST, SHIXIN LIU, and MICHAEL P. ROUT taught by faculty and visitors who are specialists in various disciplines. This course presents the fundamental principles of biochemistry Class length and frequency: Three-hour lecture, once weekly; and biophysics, with an emphasis on methodologies. In addition, two-hour discussion, twice weekly case studies are discussed, examining how physical and chemical methods have been used to establish the molecular mechanisms Prerequisite(s): Good knowledge of textbook cell biology of fundamental biological processes. -
2020– 2024 Strategic Plan
2020-2024 STRATEGIC PLAN Amy Shyer, head of the Laboratory of Morphogenesis, studies the mechanical forces and molecular A new plan is intended to cues that guide tissue formation maximize the university’s in a developing embryo. She was scientific impact over the recruited to Rockefeller in 2018. next five years A five-year strategic plan for the university, developed in 2019, sets Investing in the most audacious and a course for new investments in faculty recruitment, technological original scientists in the world acquisitions, translational efforts, and other priorities between 2020 and 2024. The plan, titled “The Convergence of Science and Medicine,” The plan calls for maintaining the open-search process that has was approved by the Board of Trustees at its November 6 meeting. driven tenure-track faculty recruitment over the past decade. A The plan’s development was overseen by President Richard P. Lifton, second key goal is the appointment of new mid-career faculty in two who led a committee of faculty members and administrators through areas: computational biology and neurodegenerative disease. The a review of Rockefeller’s strengths, operations, and aspirations. The pace of hiring will be consistent with past practice: one to two new convergence of basic science, clinical medicine, and therapeutic heads of laboratory per year, maintaining the number of heads of discovery has set the stage for exceptional advances, says Lifton, laboratory at around 75. The plan also underscores the university’s and the plan will build on the technological breakthroughs of the last continued commitment to the recruitment of exceptional graduate decade to lead a new revolution in the development of novel medicine.